ChemPlusChem最新文献

Metallo-Organic Complexes Containing Transition Metals; Synthetic Approaches and Pharmaceutical Aspects.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-23 DOI: 10.1002/cplu.202400748

Nayab Mohsin, Shehla Khalid, Nasir Rasool, Labiqa Aman, Aqsa Kanwal, Muhammad Imran

{"title":"Metallo-Organic Complexes Containing Transition Metals; Synthetic Approaches and Pharmaceutical Aspects.","authors":"Nayab Mohsin, Shehla Khalid, Nasir Rasool, Labiqa Aman, Aqsa Kanwal, Muhammad Imran","doi":"10.1002/cplu.202400748","DOIUrl":"https://doi.org/10.1002/cplu.202400748","url":null,"abstract":"Coordination compounds offer a flexible framework for the thoughtful design of novel therapeutic-metallodrugs because of the unique properties of metal ions, such as their ability to coordinate with a wide range of organic ligands, variable oxidation states, a wide range of geometries, and coordination numbers. The pharmaceutical potential of a metal ion and associated substances is validated by the prevalence of various disease states linked to a metal ion's excess or deficiency within the biological system. Researchers have sought more selective, efficacious metallodrugs that cause fewer adverse effects. Attempts have resulted in considering a large range of organic ligands, preferably polydentate ligands with demonstrated biological activity, and a large range of metals from the periodic table, primarily from the d-block. In this review, we have outlined the key coordination complexes comprising N-, O-, and S-donor ligands reported in the last six years to demonstrate the potential applications of these metallo-organic complexes. The synthetic pathways of ligands, their complexes, and their potential for therapeutic applications are highlighted.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202400748"},"PeriodicalIF":3.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrocatalytic Lignin Valorization via Enhanced H₂O₂ Generation Using a MWNCT-Modified Gas Diffusion Electrode.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-20 DOI: 10.1002/cplu.202400769

Lei Wang, Shuangyan Liu, Jinyou Meng, Meng Song, Mingli Jiao, Haomin Jiang, Yongmei Chen

引用次数: 0

Bulky Ligands for Open Channels: Manganese (II) sql MOFs from Pyridyl-Functionalised [3]Polynorbornanes.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-19 DOI: 10.1002/cplu.202500065

William Murrell, Pavel M Usov, Carol Hua, Frederick Matthew Pfeffer

引用次数: 0

Novel DMAP@Mesoporous Silica Hybrid Heterogeneous Catalysts for the Knoevenagel Condensation: Greener Synthesis through Eco-friendly Solvents.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-19 DOI: 10.1002/cplu.202400741

Julio C Fernandes P Brito, Fabio Travagin, Mauro Barbero, Cristina Esteban, Urbano Díaz, Alexandra Velty, Giovanni B Giovenzana, Ivana Miletto, Enrica Gianotti

{"title":"Novel DMAP@Mesoporous Silica Hybrid Heterogeneous Catalysts for the Knoevenagel Condensation: Greener Synthesis through Eco-friendly Solvents.","authors":"Julio C Fernandes P Brito, Fabio Travagin, Mauro Barbero, Cristina Esteban, Urbano Díaz, Alexandra Velty, Giovanni B Giovenzana, Ivana Miletto, Enrica Gianotti","doi":"10.1002/cplu.202400741","DOIUrl":"https://doi.org/10.1002/cplu.202400741","url":null,"abstract":"This article reports a sustainable synthesis of a novel organic-inorganic hybrid catalysts, featuring 4-(dimethylamino)pyridine (DMAP) immobilized onto mesoporous MCM-41 silica and amorphous Aerosil silica supports. Using (±)-2-methyltetrahydrofuran (MeTHF), a bio-based solvent, the covalent binding of DMAP to silica surfaces was achieved, reducing reliance on traditional petroleum-based solvents like toluene. The DMAP-functionalized hybrid catalysts, characterized through XRPD, TGA/DTA, FE-SEM, and FT-IR, demonstrated effective catalytic performance in the Knoevenagel condensation, a reaction relevant in producing fine chemicals and pharmaceuticals. The mesoporous MCM-41-supported catalyst exhibited superior activity due to its high surface area and ordered porous structure, with 97% yield and 99% selectivity. Stability and reusability were validated through leaching and recycling tests, confirming minimal DMAP leaching and robust catalytic performance over consecutive cycles. This green synthetic pathway underscores the potential of hybrid catalysts in advancing sustainable chemistry, promoting reduced energy consumption, and supporting a circular economy through recyclable, highly active catalysts in eco-friendly solvents. These findings demonstrate that MCM-41-supported DMAP hybrids are viable candidates for eco-friendly applications.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202400741"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifluoro-Modification Enhancing Catalytic Activity and Thermal Stability of Bis(imino)pyridylcobalt Chlorides for Linear Polyethylene.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-17 DOI: 10.1002/cplu.202500007

Zahra Hosseinzadeh, Qiuyue Zhang, Quanchao Wang, Ali Muhammad Ashfaq, Tongling Liang, Yanping Ma, Wen-Hua Sun

引用次数: 0

Stabilization of Verdigris Pigment on Paper: Evaluation of Antioxidants Under Mild Accelerated Degradation Conditions.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-17 DOI: 10.1002/cplu.202400670

Jasna Malešič, Klara Retko, Matjaž Finšgar, Irena Kralj Cigić

{"title":"Stabilization of Verdigris Pigment on Paper: Evaluation of Antioxidants Under Mild Accelerated Degradation Conditions.","authors":"Jasna Malešič, Klara Retko, Matjaž Finšgar, Irena Kralj Cigić","doi":"10.1002/cplu.202400670","DOIUrl":"https://doi.org/10.1002/cplu.202400670","url":null,"abstract":"Copper-based pigments, such as verdigris, have caused severe damage to many important historical documents, and their preservation remains a significant concern for paper conservators and researchers. This study re-evaluates the efficacy of two promising antioxidants, tetrabutylammonium bromide (TBABr) and benzotriazole (BTA), as stabilization agents for paper documents containing verdigris pigment. To assess the stability of the mock-up papers, various parameters were measured during accelerated degradation, including colour, molecular weight (Mw), and pH value. Size exclusion chromatography measurements of Mw confirmed that TBABr provided superior stabilization compared to BTA. Additionally, the total colour change was slightly more pronounced in the samples treated with BTA compared to those treated with TBABr. However, during degradation, some paper samples containing thicker application of pigment exhibited significant black and brown spots, regardless of treatment (untreated, treated with BTA, or TBABr). X-ray photoelectron spectroscopy confirmed the presence of both Cu(I) and Cu(II) oxidation states in all samples, with a higher Cu(II) content on the surface of TBABr treated samples compared to those treated with BTA. This may indicate differences in the mechanisms of degradation. Raman spectroscopy identified the spots on both untreated and TBABr-treated samples as copper(II) oxide.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202400670"},"PeriodicalIF":3.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triazole-Derived Ruthenium(II) Complexes as Novel Candidates for Cancer Therapy.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-15 DOI: 10.1002/cplu.202400775

Beatriz Royo, Oscar A Lenis-Rojas, Catarina Roma, Beatriz Carvalho, Vasco Andrade, Sofia Friães, Pablo Cabezas-Sain, Jhonathan Angel Araujo Fernández, Sabela Fernandez Vila, Alvaro J Arana, Laura Sanchez, Pedro V Baptista, Clara S B Gomes, Alexandra R Fernandes

{"title":"Triazole-Derived Ruthenium(II) Complexes as Novel Candidates for Cancer Therapy.","authors":"Beatriz Royo, Oscar A Lenis-Rojas, Catarina Roma, Beatriz Carvalho, Vasco Andrade, Sofia Friães, Pablo Cabezas-Sain, Jhonathan Angel Araujo Fernández, Sabela Fernandez Vila, Alvaro J Arana, Laura Sanchez, Pedro V Baptista, Clara S B Gomes, Alexandra R Fernandes","doi":"10.1002/cplu.202400775","DOIUrl":"https://doi.org/10.1002/cplu.202400775","url":null,"abstract":"The first examples of Ru(II) h6-arene (benzene and p-cymene) complexes containing a bidentate triazolylidene-triazolide ligand have been prepared and fully characterized. Their antiproliferative effect has been investigated against tumour cells A2780 (ovarian carcinoma), HCT116 (colorectal carcinoma), and HCT116dox (colorectal carcinoma resistant to doxorubicin), and in human dermal fibroblasts. The Ru complex bearing the p-cymene arene group exhibited a stronger antiproliferative effect across all tested cell lines, while the benzene-containing complex displayed higher selectivity toward tumor cells. Both complexes induced apoptosis, likely through ROS production (in the benzene complex), and inhibited tumorigenic processes, including cell migration and angiogenesis. In zebrafish models, they showed strong selectivity for cancer cells with minimal toxicity to healthy cells, effectively reducing the proliferation of HCT116 colorectal cancer cells. This study provides the first in vivo evidence of the anticancer potential of Ru triazolylidenes in zebrafish models.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202400775"},"PeriodicalIF":3.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greener Microplastics Removal: Progressive Replacement of Iron-Based Coagulants with Sodium Alginate and Chitosan to Enhance Sustainability.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-14 DOI: 10.1002/cplu.202400736

Marco Facchino, Loris Pietrelli, Patrizia Menegoni, Mauro Capocelli, Emanuele Limiti, Marcella Trombetta, Francesco Basoli, Marcello De Falco

{"title":"Greener Microplastics Removal: Progressive Replacement of Iron-Based Coagulants with Sodium Alginate and Chitosan to Enhance Sustainability.","authors":"Marco Facchino, Loris Pietrelli, Patrizia Menegoni, Mauro Capocelli, Emanuele Limiti, Marcella Trombetta, Francesco Basoli, Marcello De Falco","doi":"10.1002/cplu.202400736","DOIUrl":"10.1002/cplu.202400736","url":null,"abstract":"Wastewater treatment plants (WWTPs) currently represent one of the main sources for microplastics (MPs) and other emerging contaminants entering the environment. Coagulation is a longstanding and cost-effective process designed to enhance the removal of colloidal particles and proved to be efficient in the abatement of MPs. The present study investigates the feasibility of a progressive replacement of ferric chloride (FeCl3) with chitosan (CT) and sodium alginate (SA), starting from their use as coagulant aids. Coagulations tests were carried out to assess the performance of FeCl3-CT and FeCl3-SA systems in the removal of polystyrene (PS) microbeads, polyethylene (PE) and polyethylene terephthalate (PET) fragments with sizes lower than 500 μm. Results from experiments have shown that both CT and SA are useful to enhance the removal performance of conventional coagulation by improving the settling characteristics of flocs. The use of CT allows a reduction of coagulant dosage for removing PS and PE particles, while it turned out to be detrimental for the removal of PET fragments. Instead, SA at a concentration of 0.2 mg L-1 proved to be useful both to achieve higher removal rate at a medium dosage of coagulant and to improve the efficiency of the process at lower dosages.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202400736"},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Feature: Piercing the Shadows: Exploring the Influence of Signal Preprocessing on Interpreting Ultrasensitive Bioelectronic Sensor Data (ChemPlusChem 2/2025)

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-13 DOI: 10.1002/cplu.202580202

Mariapia Caputo, Lucia Sarcina, Cecilia Scandurra, Michele Catacchio, Matteo Piscitelli, Cinzia Di Franco, Paolo Bollella, Gaetano Scamarcio, Luisa Torsi, Eleonora Macchia

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Front Cover: Artificial Compartments Encapsulating Enzymatic Reactions: Towards the Construction of Artificial Organelles (ChemPlusChem 2/2025)

IF 3 4区化学

ChemPlusChem Pub Date : 2025-02-13 DOI: 10.1002/cplu.202580201

Peng Lin, Shiwei Zhang, Futa Komatsubara, Hiroaki Konishi, Eiji Nakata, Takashi Morii

引用次数: 0