ChemPlusChem最新文献

{"title":"Synthesis of DNA Building Blocks With Thiazole Fluorophores for Fluorescent Readout by Excimers and Energy Transfer","authors":"Jan Kunzmann,&nbsp;Anna-Lena Ruopp,&nbsp;Hans-Achim Wagenknecht","doi":"10.1002/cplu.70263","DOIUrl":"https://doi.org/10.1002/cplu.70263","url":null,"abstract":"<p>Two new charged DNA building blocks were synthesized with thiazole orange (TO) and dibenzothiazole (DB) as fluorescent DNA base surrogates. They promote excimer formation and energy transfer within DNA architectures, because they were incorporated as fluorophore pairs into oligonucleotides such that they interact in an interstrand and intrastrand orientation upon hybridization. Both excimer formation and energy transfer result not only in fluorescence intensity changes, but also in pronounced redshifted emission. In addition, DB was investigated as an energy donor with TO as well as cyanovinylenes and aminonaphthalimides as energy acceptors in DNA. These combinations render DB as a versatile fluorophore for DNA detection and imaging. Such sensitive fluorescent probes basically enable sequence-specific detection of nucleic acids not only through changes in fluorescence intensity but also by emission color as readout.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cplu.70263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Aggregation-Induced Emission Based Tetraphenylethylene Conjugated Sulfonamide and Sulfonate Ester: Single-Crystal X-Ray Diffraction Evaluation, Photophysical Characteristics, Self-Assembly, and Exploring Invisible Ink Applications","authors":"Sharad Survase,&nbsp;Manoj Gayke,&nbsp;Bhavin Parmar,&nbsp;J. Prakasha Reddy,&nbsp;Chirag N. Patel,&nbsp;Jichuan Xiong,&nbsp;Krunal Modi,&nbsp;Rajesh S. Bhosale","doi":"10.1002/cplu.70268","DOIUrl":"https://doi.org/10.1002/cplu.70268","url":null,"abstract":"<p>Aggregation-induced emission (AIE) active organic compounds have received significant attention owing to their superior emission properties in aggregate and solid states, which are useful in advanced material applications such as bioimaging, chemo-biosensing, optoelectronics, data security, and anti-counterfeiting. Herein, AIE-based tetraphenylethylene conjugated sulfonamide (<b>TPE-NTS</b>) and sulfonate ester (<b>TPE-OTS</b>) have been synthesized. Single-crystal X-ray diffraction analysis was carried out to determine molecular structure of <b>TPE-NTS</b> and <b>TPE-OTS</b>, and to visualize the intermolecular interactions that occur in the solid state. The <b>TPE-NTS</b> formed aggregation in dimethyl sulfoxide (DMSO) as the water content grew from 60% to 90%, resulting in the formation of a new emission peak at 471 nm. Conversely, when the water content in DMSO was increased from 50% to 90%, the <b>TPE-OTS</b> aggregation caused a new emission peak at 464 nm. The naked-eye visualization also demonstrated that <b>TPE-NTS</b> and <b>TPE-OTS</b> were AIE-active in increasing water percentage in DMSO. The optical microscope and scanning electron microscopy analysis revealed that in 70% and 90% water fractions in DMSO, <b>TPE-NTS</b> formed several micrometers-long ordered flake-like self-assembled structures, whereas <b>TPE-OTS</b> generated well-ordered micro-rods containing flower-like self-assembled structures. Calculations using density functional theory and time-dependent density functional theory showed the photophysical behavior of both <b>TPE-NTS</b> and <b>TPE-OTS</b>. The invisible inks made from <b>TPE-NTS</b> and <b>TPE-OTS</b> were inactive in daylight but activated when exposed to ultraviolet light. These invisible inks were tested for advanced anti-counterfeiting applications such as trademark document security.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratiometric Fluorescence Sensing of Human/Bovine Serum Albumin Using In Situ Formed Fe3+ Complex","authors":"Kanishk Bhardwaj,&nbsp;Ritambhara Jangir,&nbsp;Bigyan R. Jali,&nbsp;Suban K. Sahoo","doi":"10.1002/cplu.70275","DOIUrl":"10.1002/cplu.70275","url":null,"abstract":"<p>The quantification of albumin levels in biological samples is a critical biomarker for diagnosing and monitoring various pathological conditions. This study introduced a vitamin B₆ cofactor derived Schiff base (E)-(4-(((2-(1H-benzo[d]imidazol-2-yl)phenyl)imino)methyl)-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (BMLP) via the condensation of pyridoxal 5′-phosphate with 2-(1H-benzo[d]imidazol-2-yl)aniline. Schiff base BMLP formed a complex with Fe³⁺ in 2:1 binding ratio and redshifted its fluorescence emission from 417 to 474 nm, accompanied by slight quenching at 417 nm and fluorescence enhancement at 474 nm. The in situ formed BMLP─Fe³⁺ complex was employed for the ratiometric fluorescence sensing of albumins, that is, human serum albumin (HSA) and bovine serum albumin (BSA). With the addition of HSA and BSA, the fluorescence emission of BMLP─Fe³⁺ complex was quenched at 474 nm and enhanced at 417 nm. The selective ratiometric response from the BMLP─Fe³⁺ complex can be employed to detect HSA and BSA down to 3.8 and 3.6  µM, respectively. The developed fluorescence-based sensing approach was applied for quantifying HSA and BSA in real biological matrices, including milk and urine, with satisfactory recovery rates.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic, Antioxidant, Energy Storage, and Sensing Applications of rGO Loaded MnO2 Nanoparticles","authors":"Leelavathi P.,&nbsp;Venkatalakshmi V.,&nbsp;Mylarappa M.,&nbsp;Chandruvasan S.,&nbsp;Prasanna Kumar S. G.","doi":"10.1002/cplu.70274","DOIUrl":"10.1002/cplu.70274","url":null,"abstract":"<p>A reduced graphene oxide/manganese dioxide (rGO/MnO₂) was prepared via a reflux method. MnO₂ was prepared by the combustion method using neem leaf extract as a biogenic fuel. The materials were characterized using X-ray diffraction, Brunauer–Emmett–Teller, transmission electron microscopy, high-resolution transmission electron microscopy, selected area electron diffraction, EDS, XPS, UV–vis, and photoluminescence spectroscopy. The rGO/MnO₂ exhibited outstanding photocatalytic degradation of methyl violet (MV), achieving ~99.21% removal within 70 min under UV irradiation. The radical scavenging assays demonstrated markedly improved antioxidant activity for rGO/MnO₂, with a half-maximal inhibitory concentration (IC₅₀) of 186.77 μL/μg compared to rGO and MnO₂. Cyclic voltammetry (CV) and galvanostatic charge–discharge (GCD) revealed a specific capacitance of 132.71 F/g for the composite electrode, nearly double the performance of bare MnO₂. The electrode also demonstrated superior electrochemical sensing toward Hg²⁺ and Cr²⁺ metal ions, with lower limits of detection (LOD: 5.94 and 12.42 μM). These results collectively establish rGO/MnO₂ as a nanocomposite with strong potential for environmental and energy storage studies.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Detection of Perfluorooctanoic Acid by a Zn–Terpyridine and Nafion-Modified Glassy Carbon Electrode","authors":"Alyah Buzid,&nbsp;Kim J. Keohane,&nbsp;Sarah Cramp,&nbsp;Christopher S. Burke","doi":"10.1002/cplu.70272","DOIUrl":"10.1002/cplu.70272","url":null,"abstract":"<p>Perfluorooctanoic acid (PFOA), a persistent organic pollutant, poses significant environmental and health risks due to its widespread occurrence in water sources and resistance to degradation. This study investigates zinc(II) terpyridine (Zn–tpy) complexes as molecular receptors for PFOA, demonstrating capture via carboxylate binding to Zn(II) with concomitant changes to nuclear magnetic resonance (NMR) and absorbance spectra. The capture capability and redox properties of the complexes were used to develop an electrochemical method for PFOA at a glassy carbon (GC) electrode modified with a thin discontinuous Nafion overlayer that assists with preconcentration at the sensor. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square-wave voltammetry (SWV) were used to characterize the modified electrode. The electrode gave a limit of detection (LOD) of 0.407 pM and a linear range of 0.5–10 pM, with short-term intra- and interelectrode relative standard deviations (RSD) of 0.94% and 2.02%. Recoveries of 96%–98% were obtained for Cork tap water spiked with PFOA after 1:100 dilution in phosphate-buffered saline (PBS). The preliminary data suggests Zn–tpy complexes in combination with selective coatings may be applicable for class-selective electrochemical detection of perfluoroalkyl carboxylic acids, exemplified herein using PFOA.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triphenyl Imidazole-Phenothiazine Dual-Donor Organic Dyes With I–/I3– Redox Couples for Highly Efficient Indoor Dye-Sensitized Photovoltaics","authors":"Andrew Simon George,&nbsp;Manne Naga Rajesh,&nbsp;Annu Annie George,&nbsp;Sruthi Meledath Meethal,&nbsp;Suraj Soman,&nbsp; Lingamallu Giribabu","doi":"10.1002/cplu.70271","DOIUrl":"10.1002/cplu.70271","url":null,"abstract":"<p>Dye-sensitized solar cells are gaining recognition as a promising technology increasingly drawing the interest of a burgeoning array of IoT devices and wireless sensors, providing a solution to the escalating need for cordless power. We have chosen four organic sensitizers incorporating triphenyl imidazole and phenothiazine as double donors alongside a carboxylic acid as an anchoring group. Sensitizers have either benzothiadiazole (LG-P6 and LG-P8) or phenyl (LG-P5 and LG-P6) as an auxiliary acceptor, separated from the anchoring carboxylic acid group by an ethynyl bridge. The devices are fabricated using the I^–/I₃^– redox couple and evaluated under AM1.5G and indoor light conditions. The sensitizers having benzothiadiazole displayed efficiency of 5.98% and 2.81% under 1-sun conditions. Further, we have systematically evaluated device performance from 1000 to 100 lx WW CFL, WW LED, DL CFL, and DL LED light conditions. We observed efficiencies of 19.73% under 1000 lx WW CFL and 24.23% under 100 lx WW LED conditions using the LG-P6 sensitizer, which is one among the highest efficiencies reported without cosensitization to the best of our knowledge. Further, we adopted interfacial charge transfer studies using different perturbation techniques to explain the photovoltaic results.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable Acidity of Sulfated Zr–Sn Mixed Oxides for Solvent-Free Sorbitol Dehydration to Isosorbide","authors":"Jay B. Trivedi,&nbsp;Paresh H. Rana","doi":"10.1002/cplu.70273","DOIUrl":"10.1002/cplu.70273","url":null,"abstract":"<p>One of the most important processes in creating sustainable monomers for high-performance polymers is the catalytic dehydration of sorbitol obtained from biomass to isosorbide. This study investigated a series of sulfated Zr_<i>x</i>Sn_{1 − <i>x</i>}O₂ (<i>x</i> = 0.1–0.9) mixed oxides prepared by coprecipitation method for sorbitol dehydration under solvent-free conditions. Comprehensive evaluation of different characterization techniques, i.e., X-ray diffraction, Fourier transform infrared, transmission electron microscope, N₂ physisorption, and NH₃-TPD demonstrated that surface acidity, textural characteristics, and catalytic activity were greatly affected by catalyst composition. Catalyst with intermediate Zr content (0.4–0.6) had an ideal balance of weak, medium, and strong Brønsted acid sites, which resulted in complete conversion of sorbitol and higher isosorbide selectivity. 100% sorbitol conversion and 87% isosorbide selectivity were achieved with sulfated (S)-Zr_0.5Sn_0.5O₂ at 220 °C within 3 h, exceeding many reported heterogeneous solid acids catalyst. A minor loss in catalyst activity was observed after four cycles, showing its potential for long-term isosorbide production.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depolymerization of PET and Polyamide 66 Wastes Using an Iron(III) Recoverable Lewis–Brønsted Aqueous System","authors":"Emanuele Vassallo,&nbsp;Marco Rollo,&nbsp;Lavinia Paletti,&nbsp;Gianluca Ciancaleoni,&nbsp;Elisa Martinelli","doi":"10.1002/cplu.70267","DOIUrl":"10.1002/cplu.70267","url":null,"abstract":"<p>The accumulation of polyethylene terephthalate (PET) and polyamide 66 (PA66) in municipal and industrial waste streams represents a major challenge to global sustainability efforts. In this work, we report the development and optimization of a low-cost, iron-recoverable, and reconstitutable Lewis–Brønsted aqueous solution (LBAS) system for the selective depolymerization of post-consumer PET and PA66 wastes. The method employs a recyclable reaction medium and operates under mild conditions (150 °C, 2 h), achieving high monomer yields with excellent selectivity. The resulting terephthalic acid, adipic acid, and hexamethylenediammonium chloride were efficiently recovered and purified using straightforward separation techniques, whereas ethylene glycol was recovered as a stream suitable for purification by conventional industrial methods. A proof-of-concept experiment confirmed that PET and PA66 can also be depolymerized in the same medium, even though cross reactions between adipic acid and ethylene glycol prevent the quantitative monomer recovery. Therefore, mixed PET/PA66 feeds require prior separation to recover the individual monomers effectively. Overall, results demonstrate a scalable and environmentally benign approach for the chemical recycling of PET and PA66, contributing to a more sustainable plastic lifecycle and circular materials economy.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Oxidative to Reductive Stress: Metal-Dependent Mechanisms of Cancer Cell Death in Troxerutin Complexes","authors":"A. Velásquez Bravo,&nbsp;A. B. Actis Dato,&nbsp;L. G. Naso,&nbsp;E. G. Ferrer,&nbsp;P. A. M. Williams","doi":"10.1002/cplu.70262","DOIUrl":"10.1002/cplu.70262","url":null,"abstract":"<p>Flavonoid–oxidovanadium(IV) (VO) complexes have been widely investigated as anticancer agents because of their ability to induce oxidative stress in tumor cells. In contrast, Zn complexes with ligands capable of reducing intracellular reactive oxygen species (ROS) may exert antitumor effects through a reductive-stress mechanism. Herein, we report the synthesis and characterization of a Zn–troxerutin complex, its interaction with bovine serum albumin (BSA), and its anticancer activity. This study aims to correlate the chemical and biological properties of the complex after replacing a redox-active metal ion with a redox-inactive one. The Zn–troxerutin complex exhibited the same coordination mode and 1:1 metal-to-ligand stoichiometry as the VO analog. It showed dose-dependent antiproliferative activity at higher concentrations in A549, MDA-MB-231, and HCT-116 cancer cells, while reducing intracellular ROS. In HCT-116 cells, reductive stress was associated with increased glutathione (GSH) levels and mitochondrial membrane depolarization. The complex displayed greater anticancer efficacy than free troxerutin and selectivity toward cancer cells over normal HEK293 cells. BSA binding studies yielded positive Δ<i>H</i> and Δ<i>S</i> values, indicating that hydrophobic interactions drive complex formation, with binding constants within the optimal range for drug transport. These findings highlight Zn–troxerutin as a promising anticancer agent acting through reductive-stress pathways.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Dynamics of Noncovalent Interactions Modulating Passive Diffusion of Cisplatin Across a Human Breast Cancer Cell Membrane: An amIGM + GLED View","authors":"Costantino Zazza,&nbsp;Daniele Belletto,&nbsp;Stefano Scoditti,&nbsp;Nico Sanna,&nbsp;Stefano Borocci,&nbsp;Emilia Sicilia","doi":"10.1002/cplu.70258","DOIUrl":"10.1002/cplu.70258","url":null,"abstract":"<p>Passive permeation across biological membranes is governed by a delicate balance of transient noncovalent interactions that are difficult to resolve experimentally or through conventional molecular dynamics (MD) analyses alone. Here, we present a perspective on the integration of the averaged modified independent gradient model (amIGM) based on promolecular density approximation and the graphic representation of the local electron energy density (GLED) with classical MD simulations to investigate the passive translocation of the cisplatin (cisPt) anticancer drug across a model membrane representative of the lipid composition of breast cancer cells. This multiscale framework combines atomistic sampling with real-space descriptors, enabling the dynamic characterization of hydrogen bonding, dispersion forces, steric effects, and local electronic stabilization trends along the permeation pathway. As a proof of concept, we analyze the supramolecular nanosolvation environment of cisPt at finite temperature in two representative states: bulk aqueous solution and membrane center, corresponding to the maximum of the potential of mean force (+16 kcal mol⁻¹). The combined amIGM/GLED approach reveals how the nature and spatial distribution of drug–water interactions evolve in response to the local membrane environment, providing mechanistic insight into the electronic and supramolecular factors that shape the free-energy landscape of passive permeation.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}