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Bioabsorbable Cold Plasma-Generated Nitric Oxide Gas and Plasma-Activated Nitric Oxide Water: Inactivation of Oral Planktonic and Biofilm-Forming Streptococcus mutans 生物可吸收的冷等离子体产生的一氧化氮气体和等离子体活化的一氧化氮水:口服浮游和生物膜形成的变形链球菌的失活。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-30 DOI: 10.1002/cplu.70257
Sekar Ashokkumar, Anchal Bhatnagar, Tirtha Raj Acharya, Yung Oh Shin, Eun Ha Choi, Young-Chul Lee
{"title":"Bioabsorbable Cold Plasma-Generated Nitric Oxide Gas and Plasma-Activated Nitric Oxide Water: Inactivation of Oral Planktonic and Biofilm-Forming Streptococcus mutans","authors":"Sekar Ashokkumar,&nbsp;Anchal Bhatnagar,&nbsp;Tirtha Raj Acharya,&nbsp;Yung Oh Shin,&nbsp;Eun Ha Choi,&nbsp;Young-Chul Lee","doi":"10.1002/cplu.70257","DOIUrl":"10.1002/cplu.70257","url":null,"abstract":"<p>Gas plasma exposure and plasma-activated water (PAW) containing long-lived reactive oxygen species (H<sub>2</sub>O<sub>2</sub>) and nitrogen species (NO<sub>2</sub><sup>‒</sup>, NO<sub>3</sub><sup>‒</sup>) generated by a multielectrode cylindrical dielectric barrier discharge plasma effectively inactivated oral bacteria <i>Streptococcus mutans</i>, opportunistic pathogen <i>Staphylococcus aureus</i>, and foodborne or intestinal <i>Escherichia coli</i> strains, which were used as comparator organisms. Gas plasma exposure to the water alters the water pH, H<sub>2</sub>O<sub>2</sub>, and NO<sub><i>x</i></sub> (Combined NO<sub>2</sub><sup>‒</sup> &amp; NO<sub>3</sub><sup>‒</sup>) concentrations. Gas Plasma (NO<sub><i>x</i></sub> and O<sub>3</sub>) achieved a 4–6 log reduction of bacteria within 16 min, while PAW induced a 5–6 log reduction within 3 days and reduced biofilm formation by 50 ± 0.21% ~ 40 ± 8.65%. These results show that bacteria, surface morphology, live/dead and RONS imaging, and flow cytometry consistently demonstrate that biocompatible plasma treatment significantly controls oral pathogens. Plasma gas and both distilled and tap-water PAW effectively inhibited <i>S. mutans</i>, with higher selectivity than that of other bacteria. This study highlights the potential of PAW as a novel, biocompatible strategy to mitigate the virulence of oral bacteria.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-Step Electrodeposition of Feather-Like Au–Ag–CoOx-Based Composite Materials on Screen-Printed Carb on Electrode for Sertraline Sensing 在丝网印刷碳水化合物电极上一步电沉积羽毛状au - ag - coox基复合材料用于舍曲林传感。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-30 DOI: 10.1002/cplu.70254
Cem Erkmen, Hasan Saygin, Zeynep Turk, Ganesh Pattan-Siddappa, Yiğit Ergun, Mustafa Ercan
{"title":"One-Step Electrodeposition of Feather-Like Au–Ag–CoOx-Based Composite Materials on Screen-Printed Carb on Electrode for Sertraline Sensing","authors":"Cem Erkmen,&nbsp;Hasan Saygin,&nbsp;Zeynep Turk,&nbsp;Ganesh Pattan-Siddappa,&nbsp;Yiğit Ergun,&nbsp;Mustafa Ercan","doi":"10.1002/cplu.70254","DOIUrl":"10.1002/cplu.70254","url":null,"abstract":"<p>Sertraline (SRT) is a widely prescribed selective serotonin reuptake inhibitor used for the treatment of major depressive disorder, anxiety disorders, obsessive–compulsive disorder, and posttraumatic stress disorder. Accurate and sensitive determination of SRT is essential for therapeutic drug monitoring, dose optimization, pharmacokinetic studies, and the prevention of adverse effects associated with inappropriate drug exposure. In this study, a simple and sensitive electrochemical sensing platform was developed for the determination of SRT, achieving a detection limit at nanomolar levels. The sensor was fabricated by modifying the SPCE surface with feather-like Au−Ag−CoO<sub><i>x</i></sub>-based multicomponent composite materials, which provided an enhanced electroactive interface for SRT oxidation. The structural and morphological properties of the prepared material were characterized using SEM, XRD, and AFM, while its electrochemical performance was investigated by voltammetric techniques. The Au−Ag−CoO<sub><i>x</i></sub>/SPCE sensor exhibited a markedly enhanced oxidation signal for SRT relative to the bare SPCE, confirming the electrocatalytic contribution of the Au−Ag−CoO<sub><i>x</i></sub> surface architecture. Under optimized conditions, the proposed sensor showed a linear response across the two linear ranges, from 2.0 × 10<sup>−7</sup> to 2.0 × 10<sup>−6</sup> M and 2.0 × 10<sup>−6</sup> to 2.0 × 10<sup>−4</sup> M, with a detection limit of 6.1 × 10<sup>−8</sup> M. The sensor also exhibited good selectivity against the testing interfering species, along with excellent repeatability and reproducibility, with RSD values of 1.46% and 1.75%, respectively, and acceptable long-term stability by retaining approximately 85% of its initial response after 30 days. The practical applicability of the method was demonstrated through the analysis of SRT in pharmaceutical tablets, human serum, and water samples, yielding recovery values of 98.71%–102.35%, 97.45%–104.29%, and 100.80%–104.00%, respectively. Overall, the developed Au−Ag−CoO<sub><i>x</i></sub>/SPCE platform offers a reliable, cost-effective, and sensitive approach for SRT determination in pharmaceutical, biological, and environmental samples.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vapor-Phase Zinc Modification for Paper Artifacts: From Surface-Enriched Shells to Subsurface Interactions 纸制品的气相锌改性:从表面富集壳到亚表面相互作用。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-29 DOI: 10.1002/cplu.70249
Xingzhi Wang, Zirui Zhu, Yue Zhang, Rongliang Shang, Guoqi Li, Xincan Cai, Yingdong Deng, Weiyi Lin, Yixiao Liu, Fufei Cong, Peihong Yu, Lei Cao, Guohui Zhong, Tsu-Chien Weng, Xiangjun Wei, Hongbin Zhang, Jin Xie
{"title":"Vapor-Phase Zinc Modification for Paper Artifacts: From Surface-Enriched Shells to Subsurface Interactions","authors":"Xingzhi Wang,&nbsp;Zirui Zhu,&nbsp;Yue Zhang,&nbsp;Rongliang Shang,&nbsp;Guoqi Li,&nbsp;Xincan Cai,&nbsp;Yingdong Deng,&nbsp;Weiyi Lin,&nbsp;Yixiao Liu,&nbsp;Fufei Cong,&nbsp;Peihong Yu,&nbsp;Lei Cao,&nbsp;Guohui Zhong,&nbsp;Tsu-Chien Weng,&nbsp;Xiangjun Wei,&nbsp;Hongbin Zhang,&nbsp;Jin Xie","doi":"10.1002/cplu.70249","DOIUrl":"10.1002/cplu.70249","url":null,"abstract":"<p>Paper artifacts are irreplaceable carriers of human history and culture, yet they are inherently vulnerable to degradation through acidification, hydrolysis, and oxidation. Conventional conservation approaches, such as immersion and spraying, introduce liquid media and additives that can disturb fiber microstructure and alter appearance. Here we report a dry, depth-programable vapor-phase molecular infiltration strategy for paper-based cultural heritage conservation. Using diethylzinc as a precursor, we achieve either surface-confined or depth-controlled zinc incorporation within cellulose fibers by tuning exposure kinetics, yielding zinc-modified Xuan paper (Zn-X). At the molecular level, zinc coordinates with oxygen-containing functional groups in cellulose, forming Zn–O–cellulose linkages that reinforce the cellulose network. This atomic-scale modification, in synergy with the hierarchical fiber structure, imparts deacidification, hydrophobicity, improved mechanical strength, and antibacterial activity, while also reducing flame spread with enhanced char formation and post-burn legibility—all without compromising the original morphology and visual appearance. Furthermore, we demonstrate practical utility on a historical Qing-dynasty manuscript, achieving increased hydrophobic protection with minimal color change and preserved text legibility. This work establishes a precise, minimally invasive, and multifunctional platform for the sustainable conservation of paper-based cultural heritage.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-Linked Chitosan/Cellulose Microspheres for Reusable Dye Adsorption and Post-Desorption Photo-Oxidative Treatment 交联壳聚糖/纤维素微球用于可重复使用染料吸附及解吸后光氧化处理。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-29 DOI: 10.1002/cplu.70252
Yue-Jie Li, Ran Chen, Shao-Bo Li, Jin Zeng, Jing-Wen Chen, Hong-Yuan Wang, Chang-Wei Xu, Li Li, Jing Liu
{"title":"Cross-Linked Chitosan/Cellulose Microspheres for Reusable Dye Adsorption and Post-Desorption Photo-Oxidative Treatment","authors":"Yue-Jie Li,&nbsp;Ran Chen,&nbsp;Shao-Bo Li,&nbsp;Jin Zeng,&nbsp;Jing-Wen Chen,&nbsp;Hong-Yuan Wang,&nbsp;Chang-Wei Xu,&nbsp;Li Li,&nbsp;Jing Liu","doi":"10.1002/cplu.70252","DOIUrl":"10.1002/cplu.70252","url":null,"abstract":"<p>Dye-containing wastewater remains an important environmental concern because many synthetic dyes are persistent and potentially harmful to aquatic organisms and human health. In this work, a biomass-based adsorbent was evaluated together with a separate post-desorption photo-oxidative treatment step. Cellulose (CL) and chitosan (CS) were used to prepare cross-linked CS/CL (C-CS/CL) microspheres for dye removal from water, with glutaraldehyde (GA) used to improve the structural stability of the microspheres. The synthesized C-CS/CL microspheres exhibited improved mechanical stability and pH-dependent dye adsorption, with preferential uptake of anionic dyes (acid blue 93 and acid black 1) and lower uptake of cationic dyes (methyl violet and methyl green). After adsorption, the dyes were eluted, allowing the C-CS/CL microspheres to be reused for repeated dye removal. The dye-containing eluate was subsequently subjected to UV/H<sub>2</sub>O<sub>2</sub> treatment, resulting in partial degradation of the model dyes. Overall, the C-CS/CL microspheres enabled preferential adsorption and repeated reuse, while the separate UV/H<sub>2</sub>O<sub>2</sub> step provided subsequent treatment of the dye-containing eluate.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validated QuEChERS–HPLC–UV Method for Quantification of Cannabidiol in Pharmaceutical Nanoformulations QuEChERS-HPLC-UV法测定纳米药物制剂中大麻二酚的含量
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-26 DOI: 10.1002/cplu.70250
Pimpisa Chaobon, Phichaporn Bunwatcharaphansakun, Gehsirinnad Supattanachote, Katawut Namdee, Thitaphat Ngernsutivorakul
{"title":"Validated QuEChERS–HPLC–UV Method for Quantification of Cannabidiol in Pharmaceutical Nanoformulations","authors":"Pimpisa Chaobon,&nbsp;Phichaporn Bunwatcharaphansakun,&nbsp;Gehsirinnad Supattanachote,&nbsp;Katawut Namdee,&nbsp;Thitaphat Ngernsutivorakul","doi":"10.1002/cplu.70250","DOIUrl":"10.1002/cplu.70250","url":null,"abstract":"<p>Cannabidiol (CBD) nanoformulations have gained increasing interest in pharmaceutical development. However, comprehensive analytical methods for complex nanoformulated samples remain underexplored. In this study, an HPLC–UV method coupled with QuEChERS extraction was developed and validated according to ICH guidelines for nanoformulated CBD analysis. Representative matrices included spray-dried CBD-loaded lipid nanoparticle (CBD-LNP) powder and Dulbecco's modified Eagle medium (DMEM) for cell-based assays. The method showed excellent linearity (<i>R</i><sup>2</sup> &gt; 0.999) over 1–100 µg/mL for both matrices, with minimal matrix effects. The LODs were 0.17 and 0.15 µg/mL, and the LOQs were 0.51 and 0.46 µg/mL for powder and DMEM, respectively. CBD recoveries were above 90% for both powder and DMEM. Intra- and inter-day precision (%RSD) were below 2.8% and 7.8%, respectively. The validated method was applied to stability testing of nanoformulated CBD products containing 3% and 5% CBD, showing that 25 °C was the optimal storage temperature over 6 months. A cellular uptake study also revealed higher uptake of the nanoformulated CBD than the isolate and oil-based forms. Overall, this workflow provides a reliable and accessible approach for nanoformulated CBD analysis, supporting nanopharmaceutical research and routine quality control.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted Phenolic Profile, Biological Activities, Cytotoxicity, and Mineral Content of Gagea granatellii (Liliaceae) 百合花的目标酚谱、生物活性、细胞毒性和矿物质含量。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-24 DOI: 10.1002/cplu.70255
Ömer Kayir, Hacer Doğan, Ömer Koray Yaylaci, İbrahim Bilici, Erol Alver, Tuğba Uysal Kiliç
{"title":"Targeted Phenolic Profile, Biological Activities, Cytotoxicity, and Mineral Content of Gagea granatellii (Liliaceae)","authors":"Ömer Kayir,&nbsp;Hacer Doğan,&nbsp;Ömer Koray Yaylaci,&nbsp;İbrahim Bilici,&nbsp;Erol Alver,&nbsp;Tuğba Uysal Kiliç","doi":"10.1002/cplu.70255","DOIUrl":"10.1002/cplu.70255","url":null,"abstract":"<p><i>Gagea granatellii</i> was evaluated for its targeted phenolic profile, antioxidant capacity, antimicrobial activity, urease-inhibitory potential, cytotoxicity, and mineral content. Liquid chromatography–heated electrospray ionization tandem mass spectrometry (LC–HESI–MS/MS) analysis of 29 targeted phenolic compounds revealed kaempferol as the dominant compound in the flower ethanol extract (211.948 µg/g dry weight). In bulb extracts, ellagic acid was highest in the methanol extract (6.925 µg/g), whereas syringic aldehyde (5.564 µg/g) and ferulic acid (2.619 µg/g) were prominent in the water extract. Among the biological assays, the flower water extract showed the strongest 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, with a half-maximal inhibitory concentration (IC<sub>50</sub>) of 0.003 mg/mL, whereas the flower methanol extract exhibited the strongest antibacterial activity against <i>Streptococcus pyogenes</i>, with a minimum inhibitory concentration (MIC) of 0.097 mg/mL. The bulb ethanol extract showed the strongest urease inhibition (IC<sub>50</sub>: 6.01 mg/mL). Mineral analysis revealed high potassium and calcium contents, particularly in flowers, while cytotoxicity assays indicated biocompatibility up to 500 µg/mL. The findings of the present study indicate that <i>G. granatellii</i> is a promising source of phenolic constituents with antioxidant, antimicrobial, urease-inhibitory, and biocompatible properties.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclodextrins and Cyclodextrin-Based Polymers and Their Supramolecular Host–Guest Interactions for Sustainable Water Purification and Perovskite Solar Cell Devices: A Review 环糊精和基于环糊精的聚合物及其用于可持续水净化和钙钛矿太阳能电池器件的超分子主客体相互作用:综述。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-24 DOI: 10.1002/cplu.70247
Anny Leudjo Taka, Seyed Hesam-Aldin Samaei, Jinkai Xue, Vivek Maheshwari
{"title":"Cyclodextrins and Cyclodextrin-Based Polymers and Their Supramolecular Host–Guest Interactions for Sustainable Water Purification and Perovskite Solar Cell Devices: A Review","authors":"Anny Leudjo Taka,&nbsp;Seyed Hesam-Aldin Samaei,&nbsp;Jinkai Xue,&nbsp;Vivek Maheshwari","doi":"10.1002/cplu.70247","DOIUrl":"10.1002/cplu.70247","url":null,"abstract":"<p>Cyclodextrin-based polymers are a versatile class of emerging materials with unique supramolecular host–guest interaction features. Their diverse functional groups, hydrophobic cavities, and hydrophilic exteriors make them intriguing materials. These structural advantages promote molecular recognition, the absorption of guest molecules in their cavities, and the selective adsorption of guest molecules by the functional groups on their external surface. Recent research highlights that cyclodextrin polymers can simultaneously leverage supramolecular host–guest interactions and chelating ability to adsorb inorganic, organic, and microbial contaminants from water. They can also enhance the stability and performance of perovskite solar cell devices. This paper discusses the multifaceted function of cyclodextrin polymers and outlines the broad applicability of cyclodextrin-based materials in water purification and in metal halide perovskite solar cell devices.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cplu.70247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower Rim Naphthyl-Functionalized Resorcin[4]arene Conformers: Column Chromatographic Separation and Adaptive Molecular Recognition 下环萘功能化间苯二酚[4]芳烃构象:柱色谱分离和自适应分子识别。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-24 DOI: 10.1002/cplu.70256
Initha Venkatesan, Aarthi Sakthivel, Narayan Ch. Jana, Mercy Abarna Anandharaj, Wilson Raphel John Britto, Susnata Pramanik, Jayanta Samanta
{"title":"Lower Rim Naphthyl-Functionalized Resorcin[4]arene Conformers: Column Chromatographic Separation and Adaptive Molecular Recognition","authors":"Initha Venkatesan,&nbsp;Aarthi Sakthivel,&nbsp;Narayan Ch. Jana,&nbsp;Mercy Abarna Anandharaj,&nbsp;Wilson Raphel John Britto,&nbsp;Susnata Pramanik,&nbsp;Jayanta Samanta","doi":"10.1002/cplu.70256","DOIUrl":"10.1002/cplu.70256","url":null,"abstract":"<p>Conformational bias plays a crucial role in host–guest complex. Due to spatial arrangements of binding sites, binding affinities of conformers differ significantly toward a guest. Consequently, isolation of conformers is a prerequisite in understanding host–guest complexes. Herein, we report the synthesis and separation of naphthalene-functionalized resorcin[4]arenes in two distinct conformations: chair and crown. The use of bulky naphthalene as a pendant at methylene bridge results in steric strain, yielding conformationally nonconvertible isomers, with large difference in dipole moment (Δ<i>μ</i> = 6.83 D), facilitating their separation by traditional column chromatography. The isomers were characterized by NMR, mass, and X-ray diffraction analysis. Notably, in polar solvent, the crown isomer undergoes a conformational change to boat, in the upper rim, coupled with rotation of naphthalene in the lower rim. The solvent-dependent conformational and rotational change results in an electron-rich cavity in the lower rim in nonpolar solvent that binds with electron-deficient nitroaromatics. While the incorporation of naphthalene in the lower rim overcomes the bottleneck of separation of distinct conformers, the conformation-specific binding in the lower rim diversifies its applications beyond cation binding and paves a new direction in hosting guests in the lower rim which remained underexplored so far.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro and In Silico Analysis of Antioxidant and Antifungal Activity of Essential Oil From Achillea biebersteinii 水蛭挥发油抗氧化和抗真菌活性的体外和室内分析。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-22 DOI: 10.1002/cplu.70246
Zehra Torun, Tuba Unver, M. Abdullah Alagoz
{"title":"In Vitro and In Silico Analysis of Antioxidant and Antifungal Activity of Essential Oil From Achillea biebersteinii","authors":"Zehra Torun,&nbsp;Tuba Unver,&nbsp;M. Abdullah Alagoz","doi":"10.1002/cplu.70246","DOIUrl":"10.1002/cplu.70246","url":null,"abstract":"<p>This study aims to ascertain the phytochemical composition of the essential oil obtained from <i>Achillea biebersteinii</i> Afan. flowers, to validate its antioxidant and antifungal properties, and to identify the active components implicated in the antifungal mechanisms by molecular docking analysis. The 46 different compounds were identified by GC–MS analysis, 14 of which were present at concentrations greater than 1%. The main compounds are eucalyptol (21.84%), <i>cis</i>-Chrysanthenol (17.86%), camphor (15.29%), (−)-α-Pinene (6.14%), <i>trans</i>-Chrysanthenyl acetate (5.80%). The DPPH• and ABTS<sup>+</sup> radical scavenging effects of the essential oil were shown be moderately active, with IC<sub>50</sub> values of 11.76 and 3.45 mg/mL. As a result of antifungal activity, <i>A. biebersteinii</i> flower essential oil demonstrated substantial activity on <i>Candida</i> species. The MIC of the essential oil against <i>C. glabrata</i> and <i>C. parapsilosis</i> was 0.937 µL/mL, while against other <i>Candida</i> species it was 3.75 µL/mL. Molecular docking was carried out to determine the effects of compounds in the essential oil of <i>A. biebersteinii</i> flowers on antifungal activity. In silico studies showed that α-Terpineol and <i>trans</i>-Pinocarveol, with docking scores, were two of the components with the highest affinity against both <i>C. glabrata</i> and <i>C. parapsilosis</i> and were determined to be potential antifungal compounds.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13597128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schiff Base Ligands for Electrochemical Detection of Cd2+ in Water Samples: Performance and Theoretical Investigations 电化学检测水样中Cd2+的席夫碱配体:性能和理论研究。
IF 3.1 4区 化学
ChemPlusChem Pub Date : 2026-09-22 DOI: 10.1002/cplu.70251
Salma Bizid, Chaima Hassouna, Ramzi Meguebli, Mosaab Echabaane, Rafik Ben Chaabne, Mohamed Hassen V. Baouab
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