ChemPlusChem最新文献

{"title":"Recent Exploration of Right-Handed D-Sulfonyl-γ-AApeptides as Potential Tools Toward α-Helical Mimicry","authors":"Jarais Fontaine,&nbsp;Jianfeng Cai","doi":"10.1002/cplu.70239","DOIUrl":"10.1002/cplu.70239","url":null,"abstract":"<p>Over the last 15 years, our laboratory has explored peptidomimetics in diverse research areas, including AApeptide folding, structure-based design, combinatorial screening, and supramolecular chemistry. Through these efforts, we successfully introduced a new subclass of AApeptides known as sulfonyl-γ-AApeptides. In recent years, we took advantage of the synthetic scaffold and rationally designed and developed helices targeting a series of protein–protein interactions. This Perspective summarizes our recent advances in developing right-handed helical D-sulfonyl-γ-AApeptides, which closely resemble the secondary structure of canonical α-helices and represent a promising platform for α-helical mimicry.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Si/C Composite Materials Prepared by Different Processes for Lithium-Ion Battery Applications","authors":"Bo Zhao,&nbsp;Canxuan Gu,&nbsp;Yangsong Liu,&nbsp;Dong Fang,&nbsp;Shiying Chang,&nbsp;Yang Hu,&nbsp;Jun Gan","doi":"10.1002/cplu.70236","DOIUrl":"10.1002/cplu.70236","url":null,"abstract":"<p>Lithium-ion batteries are now widely used in consumer electronics and new energy vehicles. At present, commercial anode materials are mainly graphite; however, the relatively low theoretical specific capacity of graphite makes it difficult to meet the growing demand for high-energy-density storage. Silicon-based materials have abundant reserves and significant cost advantages, with a theoretical specific capacity of up to 4200 mAh g⁻¹, roughly 10 times that of graphite, making them a highly promising next-generation anode replacement material. However, silicon undergoes nearly 300% volume expansion during lithium insertion and extraction, which easily causes particle pulverization and damage to the electrode’s conductive network, ultimately leading to a severe decline in cycle life and capacity stability. Preparing Si/C composite systems can effectively address these issues. The carbon matrix can include traditional carbon precursors such as graphite and pitch, as well as novel carbon materials like graphene, MXene, and MOF-derived carbon. This paper systematically reviews mainstream Si/C composite preparation methods, including dry ball milling, spray drying, high-temperature pyrolysis, and chemical vapor deposition; analyzes the mechanisms by which each process regulates material microstructure and Si/C interface bonding; and summarizes effective strategies to enhance electrode electrochemical performance through process optimization.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulus-Responsive MOF–Hydrogel Composites for Sensing Applications","authors":"Bing Wei Chua,&nbsp;Choy Sin Lee,&nbsp;Jia En Toh,&nbsp;Wen Huei Lim","doi":"10.1002/cplu.70240","DOIUrl":"10.1002/cplu.70240","url":null,"abstract":"<p>Stimulus-responsive metal–organic frameworks (MOFs) are a subclass of MOFs that undergo physicochemical changes in response to external stimuli. The large surface area, tunable properties, and high porosity of MOFs and their dynamic nature of stimulus-responsiveness, making them highly effective for sensing applications. The luminescence properties of MOF-based sensors enable optical detection, making them cost-effective compared with conventional sensing techniques. MOFs can response to various stimuli; however, the practical application of these stimulus-responsive MOFs is limited by challenges such as poor processability and stability, requiring further advancements to enhance their real-world viability. Recently, the integration of stimulus-responsive MOFs into hydrogels has been extensively explored to improve their performance as sensors. This review highlights the utilization of stimulus-responsive MOF–hydrogel composites as sensors. The types of stimuli, preparation methods, and the distinct roles of both MOF and hydrogel components are discussed. The applications covered include biosensing, environmental remediation, and agricultural food safety monitoring, with target analytes spanning across heavy metals, toxic anions, volatile organic compounds, pesticides, biomolecules, and mycotoxins. Furthermore, the challenges and future prospects of stimulus-responsive MOF–hydrogel composites are evaluated, with rational design strategies proposed to guide future development.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sulfonation of Acetone: Characterization of Acetonedisulfonic Acid and Its Salts","authors":"Jan Langwald,&nbsp;Jan Chrubasik,&nbsp;Antonio Frontera,&nbsp;Mathias S. Wickleder","doi":"10.1002/cplu.70237","DOIUrl":"10.1002/cplu.70237","url":null,"abstract":"<p>We report the synthesis of acetonedisulfonic acid ([(HOSO₂CH₂)₂CO], ADSA) by slow reaction of acetone and oleum (65% SO₃) and subsequent removal of H₂O. The new acid was used to prepare potassium acetonedisulfonate, K₂[ADS] (ADS = [(OSO₂CH₂)₂CO]^2–), as well as the rubidium and the pyridinium salts, Rb₂[ADS] and [PyH]₃[ADS][HSO₄], respectively. Furthermore, we present an alternative one-pot reaction yielding the ammonium salt [NH₄]₂[ADS], which we characterized spectroscopically. The latter was used for a subsequent salt metathesis reaction for the preparation of the strontium and calcium salts. For the first time, all these compounds were structurally elucidated by single-crystal X-ray diffraction methods (SCXRD), revealing different conformers that the [ADS]^2– anion may adopt. Deeper insights into the structural versatility of the new compounds were gained by quantum chemical calculations. These investigations led to the molecular electrostatic potential (MEP) surfaces of the acid, as well as of the [NH₄]⁺ and the [C₅H₆N]⁺ salt, mapping the energetic landscape of the different species as a tool to predict the different reactivities. Subsequently, energetic and <i>Bader’s</i> quantum theory of atoms in molecules (QTAIM) analyses were used to show the stabilization potential of the strong hydrogen bonds present in all of the three species and their influence on the intramolecular assemblies found in the solid state.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Interaction of Flavonoids Baicalein and Scutellarein With Human Serum Albumin: Spectroscopic and Computational Study","authors":"Vanda Boršová,&nbsp;Miriama Malček Šimunková,&nbsp;Marek Štekláč","doi":"10.1002/cplu.70234","DOIUrl":"10.1002/cplu.70234","url":null,"abstract":"<p>This study explores the interaction of human serum albumin (HSA) with two flavonoids (FLs), baicalein and scutellarein, and in situ formed Cu(II)–FL complexes using fluorescence spectroscopy, molecular docking, and molecular dynamics simulations. Fluorescence quenching experiments show diminished fluorescence intensity indicating that all compounds effectively bind to HSA, with free scutellarein exhibiting slightly higher affinity. Cu(II) coordination reduces quenching efficiency; however, the binding processes remain thermodynamically favorable. UV–Vis spectroscopy confirmed well-defined ground-state HSA–flavonoid complexes with minor indications of subtle protein conformational adjustments. A novel composite scoring function integrating effective free energies and thermodynamic stability was used to compute theoretical free energies. The results are in agreement with experimental results, showing that all ligands preferentially bound in Sudlow site I, while baicalein also samples site III. Per-residue energy decomposition indicates that Cu(II) complexes are stabilized by electrostatic interactions further from the intrinsic fluorophore Trp²¹⁴. Clustering analysis reveals distinct conformational landscapes, with baicalein favoring a few dominant states, whereas scutellarein adopts a more fragmented ensemble. Overall, HSA effectively accommodates both free and Cu(II)-complexed flavonoids, with metal coordination subtly modulating binding preferences and conformational dynamics.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Role of Co0 and Lewis Basic Sites for Transfer Hydrogenation of Substituted Nitroarenes by In Situ Hydrogen Generation","authors":"Anitya Sharma,&nbsp;Dhanmani Ramchiary,&nbsp;Devendra Sharma,&nbsp;Sahil Kumar,&nbsp;Venkata Krishnan","doi":"10.1002/cplu.70233","DOIUrl":"10.1002/cplu.70233","url":null,"abstract":"<p>Designing green and efficient methods for synthesizing anilines remains a key challenge in synthetic organic chemistry. Hydrogenation of nitro compounds is one of the most significant and widely employed method for producing functionalized anilines. Consequently, designing catalytic systems capable of hydrogenating nitroarenes under environmentally benign and mild reaction conditions remains a challenge. In this regard, a highly efficient CoAl catalyst has been designed for the hydrogenation of nitroarenes to corresponding amines. Various structural, compositional, and morphological characterizations were done to understand the catalyst’s structural and surface properties. The as-synthesized catalyst exhibits excellent activity for the transfer hydrogenation of 1-chloro-4-nitrobenzene to 4-chloroaniline, achieving 98% yield at 60 °C within 1.5 h in ethanol. The developed protocol demonstrated excellent activity for wide range of substituted nitroarenes. Structure-activity relationships of CoAl show that basic sites play a crucial role in the transfer hydrogenation. Furthermore, mechanistic investigations reveal that transfer hydrogenation occurs predominantly via a hydroxylamine-mediated pathway. Moreover, the catalyst maintains good catalytic activity up to four consecutive cycles. This method eliminates the need for high-pressure H₂, offering a safe strategy for aromatic amine synthesis. The work demonstrates the potential of earth-abundant, non-noble-metal-based heterogeneous catalysts for hydrogenation reactions under environmentally benign conditions.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure and Catalytic Performance of Aluminum-Based Ozone Catalysts Prepared by a Direct Mixing Method","authors":"Can Xu,&nbsp;Xin Zhao,&nbsp;Sheng Chen,&nbsp;Chunli Wan,&nbsp;Aijuan Zhou,&nbsp;Xiejin Mao,&nbsp;Yutong Duan,&nbsp;Changyong Wu","doi":"10.1002/cplu.70221","DOIUrl":"https://doi.org/10.1002/cplu.70221","url":null,"abstract":"<p>Ozonation catalysis has attracted considerable attention for the treatment of refractory organic wastewater due to its efficient generation of reactive oxygen species (ROS). However, conventional catalyst preparation methods often suffer from drawbacks such as the production of metal-containing waste effluents. In this study, flash calcined alumina (FCA) was employed as a support to synthesize four ozonation catalysts (γ-Al, Cu-Al, Fe-Al, and Ce-Al) via a direct solid-state mixing method with CuO, Fe₂O₃, and CeO₂. The structural properties and oxalic acid degradation performance of these catalysts were systematically investigated. The catalytic activity followed the order: Cu-Al &gt; Ce-Al &gt; Fe-Al &gt;&gt; γ-Al, with Cu-Al achieving a degradation efficiency of 90%. The superior performance of Cu-Al is attributed to the optimal dispersion of CuO on the support, along with the efficient Cu²⁺/Cu⁺ redox cycle that promotes continuous ·OH generation. In contrast, the Ce⁴⁺/Ce³⁺ redox pair exhibits higher reversibility than Fe³⁺/Fe²⁺, resulting in better catalytic activity of Ce-Al. Moreover, FCA mixing method eliminates repeated calcination steps and avoids the generation of metal-containing waste, while significantly reducing energy consumption, cost, and carbon emissions.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Synthesis of Multi-Stimuli Responsive PMOEP Microgels: Phosphorus-Based Platform for Controlled Drug Delivery","authors":"Yasemin Samav,&nbsp;Cansel Tuncer","doi":"10.1002/cplu.70232","DOIUrl":"https://doi.org/10.1002/cplu.70232","url":null,"abstract":"<p>In this study, novel phosphorus-containing and pH-responsive poly[2-(methacryloyloxy)ethyl phosphate] (PMOEP) microgels were successfully synthesized for the first time via emulsion polymerization using a PBzDMA-<i>b</i>-PMEMA diblock copolymer steric stabilizer. Their performance was systematically compared with poly[2-(diethylamino)ethyl methacrylate] (PDEA) microgels cross-linked with multifunctional phosphorus agents (DMEP, TMEP) and EGDMA. Dynamic light scattering (DLS) analysis demonstrated that while EGDMA-cross-linked PDEA microgels exhibited a volumetric swelling capacity of 3330%, PMOEP microgels reached a significantly lower swelling ratio of 594% under identical conditions. Electrokinetic and DLS measurements revealed high colloidal stability across pH 3–12. The electrophoretic mobility (<i>μ</i>_e) remained consistently negative, shifting from −1.20 × 10⁻⁸ m²V⁻¹s⁻¹ at pH 3.3 to a maximum magnitude of −2.49 × 10⁻⁸ m²V⁻¹s⁻¹ at pH 11.2, providing a robust evaluation of surface charge without model-dependent conversions for swollen soft structures. Furthermore, PMOEP microgels displayed multi-stimuli responsiveness to pH, temperature, and salt concentration. Evaluated using Ibuprofen as a model drug under physiological conditions (pH 7.4, 37 °C), in vitro release showed a biphasic sustained profile, reaching 100% cumulative release over 113 h. These findings demonstrate that potentially biocompatible, phosphonic acid-functionalized microgels represent a versatile platform for advanced controlled drug delivery systems.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamic Evaluation of Micellization of an Azepanium Ionic Liquid-Based Surfactant in Water and Organic Solvent–Water Media","authors":"Supriya Pradeep Whaval,&nbsp;Amit Kumar Tiwari","doi":"10.1002/cplu.70235","DOIUrl":"https://doi.org/10.1002/cplu.70235","url":null,"abstract":"<p>A novel azepanium ionic liquid-based surfactant, 1-(2-hexadecyloxy-2-oxoethyl)-1-methylazepanium bromide (Azp-ILBS; C₂₅H₅₀NO₂Br), was successfully obtained and structurally characterized using ¹H, ¹³C NMR, FT-IR, HRMS, and CHNS elemental analysis. The critical micelle concentration (<i>cmc</i>) was evaluated via electrical conductivity measurements. Thermodynamic investigations of micellization were conducted in various water–organic solvent mixtures (ethylene glycol (EG), ethanol (Et-OH), 1,4-dioxane (DO), and N,N-dimethylformamide (DMF)) at temperatures of 303, 313, and 323 K. The influence of solvent composition and temperature on micellization behavior was systematically examined. Results indicated that <i>cmc</i> values increased from 0.328 to 0.614 mM with rising temperature from 303 to 323 K and from 0.328 to 0.761 mM with increasing solvent content of EG from 10% to 30%. All solvents showed similar trends: higher temperature and lower polarity delayed micellization, requiring higher surfactant concentrations. Degree of ionization (<i>α</i>) showed a similar trend, although a U-shaped pattern was observed specifically in the water–ethanol system. The Gibbs free energy of surfactant tail transfer (Δ<i>G</i>°_m _trans) values revealed the hydrophobic surfactant tail transfer into the micelle core from the surrounding medium as the Δ<i>G</i>°_m _trans value shifts from positive to negative on increasing temperature, affirming the role of hydrophobic interactions. Overall, the micelle formation phenomenon was observed to be spontaneous and exothermic, with entropy and enthalpy contributions varying depending on temperature and solvent environment. Notably, (Δ<i>H</i>–Δ<i>S</i>) compensation analysis shows that Azp-ILBS micellization becomes more enthalpy-driven as temperature increases. The negative Δ<i>H</i>°*_m values reflects the micelle formation is an exothermic process at zero entropy. The calculated compensation temperatures (<i>T</i>_c) at experimental temperatures 303, 313, and 323 K are 295.9, 296.15, and 301.75 K, respectively. These values are thermodynamically in a plausible range, showing a mild transition near 313 K, likely attributed to subtle variations in solute–solvent interactions or reorganization of surfactant structure.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Electrocatalytic Ethanol Oxidation Using Lanthanum Nickel Oxide Nanoparticles Anchored on Graphite Surface","authors":"Supriya Rana,&nbsp;Krishna K. Yadav,&nbsp;Kritika Sood,&nbsp;Sushma Kumai,&nbsp;Sapna Devi,&nbsp;Tanya Jamwal,&nbsp;Surinder K. Mehta,&nbsp;Menaka Jha","doi":"10.1002/cplu.70226","DOIUrl":"https://doi.org/10.1002/cplu.70226","url":null,"abstract":"<p>Ethanol oxidation reaction (EOR) using non-precious metal oxide-based nanostructures is important in the current energy landscape. However, the sluggish kinetics is one of the major bottleneck for EOR. Therefore, this work deals with the synthesis of lanthanum nickel oxide (LNO) via a facile coprecipitation method. The microstructural study confirms the formation of nanoparticles of size 40–70 nm. Furthermore, LNO NPs were deposited onto the graphite surface to evaluate their oxygen evolution reaction (OER) and EOR in an alkaline media. OER study shows an overpotential of 410 mV compared to graphite (740 mV). However, during EOR, the cyclic voltammetry (CV) shows the forward and backward oxidation peaks at 1.51 V, and the potential required to reach 10 mA/cm² decreases to 1.41 V with a high current density of ~80 mA/cm² at 2 V in the presence of ethanol in comparison to OER electrolysis in bare KOH (1.69 V). A significant reduction of ~280 mV in the required potential is observed compared to catalysis in bare KOH. The integration of LNO NPs with the graphite surface results in enhanced ethanol oxidation activity due to improved charge transport and interfacial synergy. Further, the catalytic insights have been discussed in detail using ECSA, EIS, and contact angle measurements.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}