福尔摩磺胺噻唑：结构修正。

IF 2.8 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemPlusChem Pub Date : 2025-09-03 DOI:10.1002/cplu.202500406

Claudio Maestri, Toni Grell, Fabio Travagin, Christian R Göb, Michele Castaldi, Ivana Miletto, Geo Paul, Silvia Zampini, Marco Vandone, Valentina Colombo, Giovanni B Giovenzana

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引用次数: 0

摘要

福尔摩磺胺噻唑（FSTz）是一种由磺胺噻唑与甲醛缩合而成的合成活性药物成分（API）。最初于1948年首次描述，目前用于治疗牛和宠物的细菌和原虫感染，作为缓释磺胺类磺胺噻唑和甲醛的前药。对FSTz的系统分析允许修改最初认为不明确的聚合物结构，并揭示了一个明确的环二聚体缩合产物的有趣的环烷骨架。

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Formosulfathiazole: A Structural Revision.

Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.

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来源期刊

ChemPlusChem CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

5.90

自引率

0.00%

发文量

200

审稿时长

1 months

期刊介绍： ChemPlusChem is a peer-reviewed, general chemistry journal that brings readers the very best in multidisciplinary research centering on chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. Fully comprehensive in its scope, ChemPlusChem publishes articles covering new results from at least two different aspects (subfields) of chemistry or one of chemistry and one of another scientific discipline (one chemistry topic plus another one, hence the title ChemPlusChem). All suitable submissions undergo balanced peer review by experts in the field to ensure the highest quality, originality, relevance, significance, and validity.