Japanese journal of infectious diseases最新文献_第8页

Neutralizing Antibody Levels and Epidemiological Characteristics of Patients with Breakthrough COVID-19 Infection in Toyama, Japan. 日本富山突破性新冠肺炎感染患者的中和抗体水平和流行病学特征。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-05-31 DOI: 10.7883/yoken.JJID.2023.100

Hideki Tani, Noriko Inasaki, Shunsuke Yazawa, Takahisa Shimada, Yumiko Saga, Hiroyasu Kaya, Yumiko Maruyama, Sadaya Matano, Hiroyuki Itoh, Tatsuhiko Kashii, Emiko Yamazaki, Masae Itamochi, Kazunori Oishi

{"title":"Neutralizing Antibody Levels and Epidemiological Characteristics of Patients with Breakthrough COVID-19 Infection in Toyama, Japan.","authors":"Hideki Tani, Noriko Inasaki, Shunsuke Yazawa, Takahisa Shimada, Yumiko Saga, Hiroyasu Kaya, Yumiko Maruyama, Sadaya Matano, Hiroyuki Itoh, Tatsuhiko Kashii, Emiko Yamazaki, Masae Itamochi, Kazunori Oishi","doi":"10.7883/yoken.JJID.2023.100","DOIUrl":"10.7883/yoken.JJID.2023.100","url":null,"abstract":"Breakthrough infection (BI) after coronavirus disease 2019 (COVID-19) vaccination has increased owing to the emergence of novel SARS-CoV-2 variants. In this study, we analyzed the epidemiological information and possession status of neutralizing antibodies in patients with BI using SARS-CoV-2 pseudotyped viruses. Analysis of 44 specimens from patients diagnosed with COVID-19 after two or more vaccinations showed high inhibition of infection by 90% or more against the Wuhan strain and the Alpha and Delta variants of pseudotyped viruses in 40 specimens. In contrast, almost no neutralizing activity was observed against the Omicron BA.1 variant. Many patients without neutralizing activity or BI were immunosuppressed. The results of this study show that contact with an infected person can result in BI, even when there are sufficient neutralizing antibodies in the blood. Thus, sufficient precautions must be taken to prevent infection even after vaccination.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9909073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Occupational Bloodborne Pathogen Exposure among Medical Personnel: a 4-Year Prospective Study. 医务人员职业性血源性病原体暴露的管理：一项为期4年的前瞻性研究。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-05-31 DOI: 10.7883/yoken.JJID.2022.492

Xuxia Yu, Tieer Gan, Yuexian Zhu, Minfang Wang, Lili Qian, Ye Lu

{"title":"Management of Occupational Bloodborne Pathogen Exposure among Medical Personnel: a 4-Year Prospective Study.","authors":"Xuxia Yu, Tieer Gan, Yuexian Zhu, Minfang Wang, Lili Qian, Ye Lu","doi":"10.7883/yoken.JJID.2022.492","DOIUrl":"10.7883/yoken.JJID.2022.492","url":null,"abstract":"This study examined the management of occupational bloodborne pathogen exposure at a tertiary hospital in China. This prospective study was conducted at the Zhejiang Hospital of Traditional Chinese Medicine between January 2016 and December 2019. Data on bloodborne occupational exposure management were collected. In total, 460 exposures were reported. The majority of exposures (40.2 %) were from hepatitis B virus (HBV)-positive index patients. Of the 460 cases, 453 (98.5%) exposures were reported timeously, and 371 (80.7%) cases received emergency treatment response and management. Sixty-eight personnel (93.2%) received timely prophylaxis treatment. Only 82/113 (72.6%) personnel completed the recommended follow-up period. Outsourced personnel(P = 0.002) and interns (P = 0.011) were independent follow-up factors. Although adequate compliance was achieved with timely reporting and prophylactic medication, there is room for improvement in terms of emergency treatment response and follow-up compliance. Furthermore, HBV vaccination and improved follow-up with outsourced personnel are recommended.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9924764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Febrile Reactions Associated with High IgG Antibody Titers after the Second and Third BNT162b2 Vaccinations in Japan. 日本第二次和第三次接种BNT162b2疫苗后与高IgG抗体滴度相关的发热反应。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-04-28 DOI: 10.7883/yoken.JJID.2022.677

Nobuyasu Wakazono, Katsura Nagai, Arei Mizushima, Yukiko Maeda, Natsuko Taniguchi, Toshiyuki Harada, Emiko Satou, Nao Mae, Ken Furuya

{"title":"Febrile Reactions Associated with High IgG Antibody Titers after the Second and Third BNT162b2 Vaccinations in Japan.","authors":"Nobuyasu Wakazono, Katsura Nagai, Arei Mizushima, Yukiko Maeda, Natsuko Taniguchi, Toshiyuki Harada, Emiko Satou, Nao Mae, Ken Furuya","doi":"10.7883/yoken.JJID.2022.677","DOIUrl":"10.7883/yoken.JJID.2022.677","url":null,"abstract":"Adverse events are potentially associated with an IgG response after BNT162b2 vaccination for severe acute respiratory syndrome coronavirus 2. In this study, we investigated the side effects of the BNT162b2 vaccine using a health questionnaire and examined its relationship with IgG antibody titers. Serum samples were collected from participants 3 months after the second vaccination, immediately before the third vaccination, and 1 and 3 months after the third vaccination. A total of 505 participants who received three doses of vaccine were eligible for inclusion in the analysis. The results showed that post-vaccination body temperature correlated with anti-spike-receptor-binding domain (anti-S-RBD) antibody titers measured 3 months after the second (r = 0.30, P < 0.001) and third (r = 0.14, P < 0.001) vaccinations. Multivariate linear regression analysis revealed that age and severe swelling were negatively associated, whereas female sex, body temperature, and heat sensation were positively associated with log-transformed anti-S-RBD antibody levels after the second vaccination. After the third vaccination, body temperature and fatigue were positively associated, and female sex was negatively associated, with the log-transformed anti-S-RBD antibody levels. These results suggest that post-vaccination fever may be a marker of a high antibody titer.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9379359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics of Human Pulmonary Dirofilariasis in Japan: An Uncommon Differential Diagnosis of a Solitary Pulmonary Nodule. 日本人肺丝虫病的临床特征：孤立性肺结节的罕见鉴别诊断。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-05-31 DOI: 10.7883/yoken.JJID.2022.617

Kengo Oshima

{"title":"Clinical Characteristics of Human Pulmonary Dirofilariasis in Japan: An Uncommon Differential Diagnosis of a Solitary Pulmonary Nodule.","authors":"Kengo Oshima","doi":"10.7883/yoken.JJID.2022.617","DOIUrl":"10.7883/yoken.JJID.2022.617","url":null,"abstract":"Human pulmonary dirofilariasis (HPD) is a zoonotic disease caused by Dirofilaria immitis. Most HPD cases are asymptomatic and are either detected during annual health checkups or incidentally identified during the investigation of other diseases, particularly primary or metastatic pulmonary lung cancers. However, the frequency and clinical features of Japanese patients with HPD remain unclear. We analyzed data from the Japanese Medical Abstract Society database and identified 69 cases between 1978 and 2022. The incidence of HPD increased until the 2000s but declined markedly in the 2010s. The incidence is higher in the southwestern region and lower in the northeastern region of Japan. Health checkups are the primary diagnostic opportunities. The Chugoku and Shikoku regions have had high incidence rates per population. The diagnosis of HPD using a noninvasive procedure is typically difficult because of the absence of specific clinical symptoms, and approximately 70% of the cases are detected using video-assisted thoracoscopic surgery. Climate change may increase the incidence of HPD in the northeastern region of Japan, and travel to countries with poor vector control may be a risk factor for HPD transmission. Physicians should consider this parasitic infectious disease when examining patients presenting with solitary lung nodules.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9909071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Factors That Affect the Detection Duration of SARS-CoV-2 in Loop Mediated Isothermal Amplification among COVID-19 Inpatients. 影响新冠肺炎住院患者SARS-CoV-2环内介导等温扩增检测持续时间的因素分析。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-05-31 DOI: 10.7883/yoken.JJID.2023.095

Kohei Maruyama, Kiyoshi Sekiya, Noriyuki Yanagida, Kanae Nakayama, Yusuke Kushida, Shuhei Yasuda, Daisuke Fukumoto, Satoshi Hosoya, Hiromitsu Moriya, Manabu Katsumi

{"title":"Analysis of the Factors That Affect the Detection Duration of SARS-CoV-2 in Loop Mediated Isothermal Amplification among COVID-19 Inpatients.","authors":"Kohei Maruyama, Kiyoshi Sekiya, Noriyuki Yanagida, Kanae Nakayama, Yusuke Kushida, Shuhei Yasuda, Daisuke Fukumoto, Satoshi Hosoya, Hiromitsu Moriya, Manabu Katsumi","doi":"10.7883/yoken.JJID.2023.095","DOIUrl":"10.7883/yoken.JJID.2023.095","url":null,"abstract":"In COVID-19 patients who are immunocompromised or have severe COVID-19, the duration of infectious viral shedding may be longer, and a longer isolation duration is recommended. At the National Sagamihara Hospital, a decline in the viral load to end the isolation of hospitalized patients with COVID-19 was confirmed using loop-mediated isothermal amplification (LAMP). However, a subset of patients displayed LAMP positivity for more than 20 days after symptom onset. Therefore, we conducted a retrospective observational study to investigate the factors that affect the persistence of LAMP positivity. This study included a total of 102 participants. The severity of COVID-19 was mild (25.5%), moderate (67.6%), or severe (6.9%). The median number (interquartile range) of days until negative LAMP results from symptom onset were 16 (14-19) days. Multivariate logistic regression analysis showed that patients ≥55 years and/or those with the delta variant were correlated with persistent LAMP positivity for more than 20 days after symptom onset. This study identified age, the delta variant, and oxygen requirement as factors that contribute to persistently positive LAMP results. Therefore, it is posited that in these patients, the implementation of LAMP for deisolation would result in a prolonged isolation duration.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9924768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Analysis in Tissue Samples Acquired by Minimally Invasive Autopsy in Out-of-Hospital Deaths with Postmortem Degeneration. 新冠肺炎对经微创尸检获得的组织样本进行分析，这些样本用于尸检后死亡的病理变性。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2023.140

Yuichiro Hirata, Yohsuke Makino, Shun Iida, Harutaka Katano, Sayaka Nagasawa, Hirofumi Rokutan, Munetoshi Hinata, Akiko Iwasaki, Yoichi Yasunaga, Hiroyuki Abe, Masako Ikemura, Ayumi Motomura, Kei Kira, Susumu Kobayashi, Shigeki Tsuneya, Suguru Torimitsu, Isao Yamamoto, Kimiko Nakagawa, Iwao Hasegawa, Shinji Akitomi, Daisuke Yajima, Tetsuo Ushiku, Hisako Saitoh, Tadaki Suzuki, Hirotaro Iwase

{"title":"COVID-19 Analysis in Tissue Samples Acquired by Minimally Invasive Autopsy in Out-of-Hospital Deaths with Postmortem Degeneration.","authors":"Yuichiro Hirata, Yohsuke Makino, Shun Iida, Harutaka Katano, Sayaka Nagasawa, Hirofumi Rokutan, Munetoshi Hinata, Akiko Iwasaki, Yoichi Yasunaga, Hiroyuki Abe, Masako Ikemura, Ayumi Motomura, Kei Kira, Susumu Kobayashi, Shigeki Tsuneya, Suguru Torimitsu, Isao Yamamoto, Kimiko Nakagawa, Iwao Hasegawa, Shinji Akitomi, Daisuke Yajima, Tetsuo Ushiku, Hisako Saitoh, Tadaki Suzuki, Hirotaro Iwase","doi":"10.7883/yoken.JJID.2023.140","DOIUrl":"10.7883/yoken.JJID.2023.140","url":null,"abstract":"Minimally invasive autopsy (MIA) is an alternative to a full autopsy for the collection of tissue samples from patients' bodies using instruments such as a biopsy needle. MIA has been conducted in many cases of coronavirus disease 2019 (COVID-19) and has contributed to the elucidation of the disease pathogenesis. However, most cases analyzed are hospital deaths, and there are few reports on the application of MIA in out-of-hospital deaths with varying extents of post-mortem changes. In this study, MIA and autopsies were performed in 15 patients with COVID-19 2-30 days after death, including 11 out-of-hospital deaths. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome detection by reverse transcriptase quantitative polymerase chain reaction using MIA samples was mostly consistent with autopsy samples, particularly lung tissue, even in out-of-hospital cases. MIA had high sensitivity and specificity (> 0.80). Histological examination of lung tissue obtained by MIA showed characteristics of COVID-19 pneumonia, with 91% agreement with autopsy samples, whereas localization of SARS-CoV-2 protein in lung tissue was indicated by immunohistochemistry, with 75% agreement. In conclusion, these results suggest that MIA is applicable to out-of-hospital deaths due to COVID-19 with various postmortem changes, especially when autopsies are not available.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fatal Case of Disseminated Infection Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Clone. 社区相关性耐甲氧西林金黄色葡萄球菌USA300克隆引起播散性感染致死1例

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 DOI: 10.7883/yoken.JJID.2022.578

Hiroyuki Ote, Hideyuki Ito, Taroh Akira, Motoyuki Sugai, Junzo Hisatsune, Yuki Uehara, Yuichiro Oba

{"title":"A Fatal Case of Disseminated Infection Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Clone.","authors":"Hiroyuki Ote, Hideyuki Ito, Taroh Akira, Motoyuki Sugai, Junzo Hisatsune, Yuki Uehara, Yuichiro Oba","doi":"10.7883/yoken.JJID.2022.578","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.578","url":null,"abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) USA300 is a representative community-associated MRSA (CA-MRSA) clone worldwide. Herein, we report the case of a patient with USA300 clone infection who could not be salvaged. A 25-year-old man who had sex with men presented with symptoms including fever persisting for one week and skin lesions located on the buttocks. Computed tomography imaging showed multiple nodules and consolidations, especially in the peripheral lung fields, right iliac vein thrombosis, and pyogenic myositis of medial thighs bilaterally. Blood cultures revealed MRSA bacteremia. The patient's condition deteriorated rapidly, complicated by acute respiratory distress syndrome and infective endocarditis. Despite the intubation on the 6th hospital day, he died on the 9th day. Multilocus sequence typing of this patient's MRSA strain revealed sequence type 8 with a staphylococcal cassette chromosome of mec type IVa, Panton-Valentine leukocidin gene, and the arginine catabolic mobile element, indicating presence of the USA300 clone. Patients with CA-MRSA skin lesions presenting with furuncles or carbuncles on the lower body are at a higher risk of severe disease. The patient's background, appearance, and location of skin lesions are critical for the early diagnosis of severe CA-MRSA infection.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9851476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Characteristics of the Virus Detected in the First Mpox Imported Case in Tokyo, Japan. 在日本东京第一例猴痘输入病例中检测到的病毒遗传特征。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 Epub Date: 2023-03-31 DOI: 10.7883/yoken.JJID.2022.546

Fumi Kasuya, Akane Negishi, Ryota Kumagai, Isao Yoshida, Kou Murakami, Takushi Fujiwara, Michiya Hasegawa, Sachiko Harada, Arisa Amano, Makoto Inada, Sho Saito, Shinichiro Morioka, Norio Ohmagari, Yoshiyuki Sugishita, Hirofumi Miyake, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura

{"title":"Genetic Characteristics of the Virus Detected in the First Mpox Imported Case in Tokyo, Japan.","authors":"Fumi Kasuya, Akane Negishi, Ryota Kumagai, Isao Yoshida, Kou Murakami, Takushi Fujiwara, Michiya Hasegawa, Sachiko Harada, Arisa Amano, Makoto Inada, Sho Saito, Shinichiro Morioka, Norio Ohmagari, Yoshiyuki Sugishita, Hirofumi Miyake, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura","doi":"10.7883/yoken.JJID.2022.546","DOIUrl":"10.7883/yoken.JJID.2022.546","url":null,"abstract":"Mpox, caused by the mpox virus (MPXV), produces symptoms similar to those of smallpox when transmitted to humans. Since 1970, this disease has been endemic, particularly in Africa. However, since May 2022, the number of patients without a history of travel to endemic areas has increased rapidly globally. Under these circumstances, in July 2022, two different real-time PCR methods were used on specimens brought to the Tokyo Metropolitan Institute of Public Health. MPXV was detected in the skin samples, and it was inferred that the virus was a West African strain. Furthermore, a more detailed analysis of the genetic characteristics of the detected MPXV using next-generation sequencing revealed that the MPXV detected in Tokyo was strain B.1, which corresponds to the same strain that is prevalent in Europe and the USA. This suggests that mpox reported for the first time in Japan was imported and related to outbreaks in Europe and the USA. Therefore, it is necessary to continue monitoring outbreaks in Japan in conjunction with global epidemics.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9857114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Fractional Exhaled Nitric Oxide (FeNO) Serve as a Clinical Indicator for Patients Hospitalized with Crimean-Congo Hemorrhagic Fever? 部分呼气一氧化氮（FeNO）能作为克里米亚-刚果出血热住院患者的临床指标吗？

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 Epub Date: 2023-03-31 DOI: 10.7883/yoken.JJID.2022.470

Ferhan Kerget, Buğra Kerget

引用次数: 0

Evolution and Phylodynamics of the Hemagglutinin Protein of Influenza A/(H1N1)pdm09 Virus Isolates from India from 2009 to 2020. 2009 - 2020年印度甲型H1N1流感pdm09病毒分离株血凝素蛋白的进化和系统动力学

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 DOI: 10.7883/yoken.JJID.2022.453

Kiruba Ramesh, Kannapiran Ethiraj, Sivasubramanian Srinivasan, Kaveri Krishnasamy, Kumar Rajendran, Gracyfathima Selvaraj, Padmapriya Padmanaban

{"title":"Evolution and Phylodynamics of the Hemagglutinin Protein of Influenza A/(H1N1)pdm09 Virus Isolates from India from 2009 to 2020.","authors":"Kiruba Ramesh, Kannapiran Ethiraj, Sivasubramanian Srinivasan, Kaveri Krishnasamy, Kumar Rajendran, Gracyfathima Selvaraj, Padmapriya Padmanaban","doi":"10.7883/yoken.JJID.2022.453","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.453","url":null,"abstract":"Influenza A/(H1N1)pdm09 virus evolves through continuous antigenic variation in both surface antigens, such as hemagglutinin (HA) and neuraminidase (NA) proteins, which affect its pathogenicity, the effectiveness of the host immune response, and drug resistance. This study reports the evolution and dynamics of 527 HA protein sequences of influenza A/(H1N1)pdm09 Indian isolates submitted from 2009 to 2020. These isolates were aligned with a reference sequence and 22 sequences representing different clades using MEGA X, and subjected to phylogenetic analysis. The strains were predominantly grouped in clades 6B.1 and 6B.2. Prediction of glycosylation sites using the BioEdit and NetNglyc servers showed 12 glycosylation sites distributed in both the stem and globular head regions of HA. Functional evaluation showed that there were 22 deleterious mutations that could affect the function of HA. In addition, 403 unique mutations were distributed across various isolates, indicating the dynamics of antigenic variation in Indian isolates. These results provide an understanding of the frequency, phylodynamics, and impact of mutations in Indian isolates of influenza A/(H1N1)pdm09 relative to global isolates. Monitoring the genomic evolution of the virus will support studies on strain selection for vaccine development and devising control and prevention measures to manage this respiratory infection.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0