Japanese journal of infectious diseases最新文献_第8页

Did Financial Social Support for Tuberculosis Patients Lead to Better Treatment Outcomes in Türkiye during 2018-2019? 在2018-2019年期间，对结核病患者的经济社会支持是否会导致更好的治疗效果?

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.196

Selda Sahan, Seher Topluoglu, Fehminaz Temel, Mehmet Enes Gokler, Sedat Kaygusuz

{"title":"Did Financial Social Support for Tuberculosis Patients Lead to Better Treatment Outcomes in Türkiye during 2018-2019?","authors":"Selda Sahan, Seher Topluoglu, Fehminaz Temel, Mehmet Enes Gokler, Sedat Kaygusuz","doi":"10.7883/yoken.JJID.2023.196","DOIUrl":"10.7883/yoken.JJID.2023.196","url":null,"abstract":"This study examined which factors, including the regular financial social support program, influence tuberculosis (TB) treatment outcomes and success rates. Patients with TB registered during 2018-2019 were included in this retrospective cohort study. We classified them into 2 groups: those who received financial support for at least one month, and those who did not. Of the 22,867 sampled patients, 5,033 received financial social support and 17,834 did not. The success rate was 11.9% higher among patients who received financial social support than among those who did not (97.34% versus 85.40%). After controlling for other factors, the success rate among all patients was 1.3 times higher for female, 2.6 times higher for those under 50 years, 1.5 times higher for extra-pulmonary TB, 1.5 times higher for a new case, 5.9 times higher for drug susceptible TB, and 5.8 times higher for those who received financial support. Crucially, this is the first study from Türkiye evaluating the effect of a regular financial social support program on TB treatment outcomes since the program began in 2018. We recommend regular financial support for patients with TB in all countries.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10494630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Participation in Rubella Antibody Testing among Working-Aged Men during Annual Health Check-Ups from 2019 to 2022 in Japan. 2019 - 2022年日本劳动年龄男性年度健康检查中风疹抗体检测参与趋势

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2022.614

Ai Hori, Bibha Dhungel, Satsue Nagahama

{"title":"Trends in Participation in Rubella Antibody Testing among Working-Aged Men during Annual Health Check-Ups from 2019 to 2022 in Japan.","authors":"Ai Hori, Bibha Dhungel, Satsue Nagahama","doi":"10.7883/yoken.JJID.2022.614","DOIUrl":"10.7883/yoken.JJID.2022.614","url":null,"abstract":"In 2019, the Japanese government established a scheme for rubella antibody testing of men born between 1962 and 1978 during workplace health check-ups. However, the use of vouchers for rubella antibody testing was limited. Health check-up data analyses are needed to determine the reason why rubella antibody testing is not widely used. In this study, we aimed to describe changes in rubella antibody test-taking behavior during health check-ups during the first 3 years of the rubella catch-up campaign in Japan. In 2019, 2020, and 2021 (2020 in some areas) vouchers were sent to men born during the fiscal years 1972-1978, 1966-1971, and 1962-1965, respectively. We calculated the prevalence in men born between 1962 and 1978 who underwent rubella antibody testing during mandatory health check-ups under the Industrial Health and Safety Act. Rubella antibody testing uptake was relatively high (approximately 15%) in all three age groups soon after the distribution of the vouchers and then declined to below 2% during the second and third years. Further population-based approaches with continuous public engagement are required in workplaces to effectively promote and expand the rubella vaccination program in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism rs8177374 and Cytokine (IFN-γ, TNF-α, IL-10, TGF-β) Levels in Diverse Malaria Manifestations upon P. falciparum and P. vivax Infections. MyD88-Adaptor-Like (MAL)基因多态性rs8177374和细胞因子(IFN-γ、TNF-α、IL-10、TGF-β)水平在恶性疟原虫和间日疟原虫感染不同疟疾表现中的作用

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.079

Asima Rani, Syed Kashif Nawaz, Muhammad Arshad, Najma Arshad

{"title":"Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism rs8177374 and Cytokine (IFN-γ, TNF-α, IL-10, TGF-β) Levels in Diverse Malaria Manifestations upon P. falciparum and P. vivax Infections.","authors":"Asima Rani, Syed Kashif Nawaz, Muhammad Arshad, Najma Arshad","doi":"10.7883/yoken.JJID.2023.079","DOIUrl":"10.7883/yoken.JJID.2023.079","url":null,"abstract":"This study investigated the role of genetic variant rs8177374 in MAL/TIRAP gene in mediating the cytokine levels of IFN-γ, TNF-α, IL-10, and TGF-β in malaria patients due to Plasmodium falciparum or P. vivax infection. The study included human blood samples collected from patients with malaria (n = 228) and healthy controls (n = 226). P. falciparum and P. vivax groups were established based on the causative species of Plasmodium. Malaria samples were divided into mild and severe malaria groups based on the symptoms that appeared in the patients, according to the WHO criteria. In a previous study, we genotyped rs8177374 via allele specific PCR strategy. In this study, cytokine levels were estimated in the blood plasma of rs8177374 genotype samples via Sandwich Enzyme Linked Immunosorbent Assay kits. Increased IFN-γ and TNF-α levels in presence of CC genotype indicates the role of CC genotype in both severe and mild malaria groups. Enhanced IL-10 levels in the CT genotype and mild malaria groups suggest a role of CT genotype and IL-10 in the mild clinical outcomes of malaria. The rs8177374 polymorphism in MAL/TIRAP plays an important role in malaria pathogenesis.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-to-Lymphocyte Ratio and the Systemic Immune-Inflammation Index: Biomarkers in Infants with Bronchiolitis: a Cross-Sectional Study. 中性粒细胞与淋巴细胞比率和全身免疫炎症指数:毛细支气管炎婴儿的生物标志物:一项横断面研究。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-07-31 DOI: 10.7883/yoken.JJID.2023.062

Özlem Erdede, Erdal Sarı, Nihan Uygur Külcü, Rabia Gönül Sezer Yamanel

{"title":"Neutrophil-to-Lymphocyte Ratio and the Systemic Immune-Inflammation Index: Biomarkers in Infants with Bronchiolitis: a Cross-Sectional Study.","authors":"Özlem Erdede, Erdal Sarı, Nihan Uygur Külcü, Rabia Gönül Sezer Yamanel","doi":"10.7883/yoken.JJID.2023.062","DOIUrl":"10.7883/yoken.JJID.2023.062","url":null,"abstract":"The use of a novel inflammatory indicator, the systemic immune-inflammatory index (SII), in pediatric patients with bronchiolitis remains unreported. Therefore, this study investigated the relationship between the SII and the neutrophil-to-lymphocyte ratio (NLR) in patients with respiratory syncytial virus (RSV) and non-RSV bronchiolitis and clinical severity prediction. This study analyzed the data of 155 patients aged <2 years who were hospitalized for viral bronchiolitis caused by RSV and/or other viral pathogens. The SII (platelet count × [neutrophil/lymphocyte]) was calculated and compared among patients with RSV mono-infections, other viral mono-infections, and RSV co-infections. Severity was defined by the number of days of supplemental oxygen treatment. The NLR and SII were significantly higher in the non-RSV mono-infection group than in the RSV mono-infection group, and the number of days of supplemental oxygen therapy was significantly higher in the RSV mono-infection group. No significant differences in the NLR, SII, or days of supplemental oxygen therapy were found between the RSV mono-infection and RSV co-infection groups. Although patients with RSV mono-infection showed more severe clinical findings than those without non-RSV mono-infection, the NLR and SII values were significantly higher in the non-RSV mono-infection group. Therefore, the NLR and SII do not appear to be very useful measurements for determining the severity of acute bronchiolitis attacks; however, lower NLR and SII values in the RSV group compared to the non-RSV group may be potential biomarkers for RSV infection. Therefore, further studies are warranted.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9899814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge about Hepatitis E and Influencing Factors among Residents in Qingdao: a Cross-Sectional Study. 青岛市居民戊型肝炎知识及其影响因素的横断面研究

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2023.144

Wenliang Fei, Wencheng Wang, Xiaofan Li, Sicheng Hao, Feng Yang

引用次数: 0

Enterovirus Meningitis without Pleocytosis: a Retrospective Observational Study in Adults. 无多胞症的肠病毒性脑膜炎:一项成人回顾性观察研究。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2023.123

Dongkeun Roh, Woochan Jeon, Jisook Lee

{"title":"Enterovirus Meningitis without Pleocytosis: a Retrospective Observational Study in Adults.","authors":"Dongkeun Roh, Woochan Jeon, Jisook Lee","doi":"10.7883/yoken.JJID.2023.123","DOIUrl":"10.7883/yoken.JJID.2023.123","url":null,"abstract":"Reverse-transcription polymerase chain reaction (RT-PCR)-confirmed enterovirus (EV) meningitis without pleocytosis has only been previously reported in children. In this study, we examined the frequency of EV meningitis without pleocytosis in adults and compared its clinical features. We retrospectively analyzed the data of adult patients with EV meningitis confirmed using cerebrospinal fluid (CSF) RT-PCR. Among the 17 patients included in this study, 58.8% showed no pleocytosis. The median age and clinical symptoms did not differ between the pleocytosis and non-pleocytosis groups. There were no statistically significant differences in seasonal variation or time from the onset of meningitis symptoms to lumbar puncture. The peripheral white blood cell (WBC) count in patients with pleocytosis was significantly higher than that in patients without pleocytosis. The median CSF pressure showed a higher trend in the non-pleocytosis group. Patients with CSF pressures higher than normal were more common in the non-pleocytosis group. The median CSF protein values were higher than the normal values in both groups. We confirmed the high frequency of EV meningitis without pleocytosis in adults. Accurate diagnosis using RT-PCR is necessary when meningitis symptoms are prominent during an EV epidemic, and CSF protein levels and pressure are high, even if the CSF WBC count is normal.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of Toxin Genes and Polymerase Chain Reaction-Based Open Reading Frame Type Analyses for Severe Staphylococcus aureus Infection in Children. 毒素基因和基于聚合酶链反应的开放阅读框型分析对儿童重症金黄色葡萄球菌感染的重要性。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.194

Noriko Takeuchi, Naruhiko Ishiwada

{"title":"Importance of Toxin Genes and Polymerase Chain Reaction-Based Open Reading Frame Type Analyses for Severe Staphylococcus aureus Infection in Children.","authors":"Noriko Takeuchi, Naruhiko Ishiwada","doi":"10.7883/yoken.JJID.2023.194","DOIUrl":"10.7883/yoken.JJID.2023.194","url":null,"abstract":"This study analyzed 26 Staphylococcus aureus strains, including 16 methicillin-resistant S. aureus (MRSA) and 10 methicillin-susceptible S. aureus (MSSA), collected from eight medical institutions in the Chiba Prefecture that requested a toxin gene analysis between 2015 and 2021. A total of 14 Panton-Valentine leukocidin (PVL) positive strains were identified, including MSSA. PVL-positive strains were classified into seven types according to polymerase chain reaction-based open reading frame typing (POT); of these types, three POT MRSA strains have not been previously reported, and one has been previously reported as PVL-negative. Some strains tested positive for both PVL and toxic shock syndrome toxin 1. One POT type was identified in both PVL-positive and PVL-negative strains. To the best of our knowledge, this is the first report on the regional spread of highly pathogenic S. aureus strains based on the POT method in children from multiple medical institutions. This method is useful for estimating the spread of toxin gene-carrying strains in the community owing to its association with toxin genes. As the number of PVL-positive strains in Japan increases, it is important to analyze the isolates of severe S. aureus infections in children by combining toxin gene analyses with the POT method.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacterium tuberculosis Rv2653 Protein Promotes Inflammation Response by Enhancing Glycolysis. 结核分枝杆菌Rv2653蛋白通过增强糖酵解促进炎症反应。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-07-31 DOI: 10.7883/yoken.JJID.2022.647

Yaman Du, Rui Zheng, Hongli Yin, Li Ma, Jingfang Li, Yun Chen, Xi Zhang, Pengzuo Tao, Lili Gao, Li Yang, Liang He

{"title":"Mycobacterium tuberculosis Rv2653 Protein Promotes Inflammation Response by Enhancing Glycolysis.","authors":"Yaman Du, Rui Zheng, Hongli Yin, Li Ma, Jingfang Li, Yun Chen, Xi Zhang, Pengzuo Tao, Lili Gao, Li Yang, Liang He","doi":"10.7883/yoken.JJID.2022.647","DOIUrl":"10.7883/yoken.JJID.2022.647","url":null,"abstract":"Mycobacterium tuberculosis (M.tb) infection causes the communicable disease tuberculosis (TB), a major disease and one of the leading causes of death worldwide. The protein encoded by the region of deletion (RD) in M.tb mediates the pathogenic properties of M.tb by inducing an inflammatory response or disrupting host cell metabolism. We cloned and purified the Rv2653 protein from RD13 to explore its regulatory effects on host macrophages. We found that Rv2653 promoted glycolysis and upregulated the expression of key glycolytic enzymes, namely, hexokinase 2 (HK2) and lactate dehydrogenase-A (LDHA) in human leukemia monocytic (THP1) cells. Furthermore, the induction of glycolysis by Rv2653 contributes to the activation of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome. Rv2653 activated the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, and the mTORC1 inhibitor NR1 blocked Rv2653-induced HK2, LDHA, and NLRP3 expression. siRNA interfering with HK2 or LDHA significantly inhibited the activation of NLRP3 inflammasome by Rv2653, blocked Rv2653-triggered inflammatory factors interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, reactive oxygen species (ROS), and nitric oxide (NO), and promoted the survival of Bacillus Calmette-Guerin (BCG) in THP1 cells. Overall, Rv2653 promoted glycolysis by activating the mTORC1 signaling pathway, activating the NLRP3 inflammasome, and releasing inflammatory factors, ultimately inhibiting the intracellular survival of BCG in THP1 cells. Therefore, we revealed that anti-M.tb immune mechanisms induced by Rv2653 contribute to the development of new anti-TB strategies.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Single-Center Evaluation of Pediatric Measles Cases in Istanbul, Türkiye, in 2019. 2019年土耳其伊斯坦布尔儿童麻疹病例的单一中心评估。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-04-28 DOI: 10.7883/yoken.JJID.2022.701

Mahmut Caner Us, Kübra Coci, Erkan Akkuş, Berker Okay, Gülşen Akkoç

引用次数: 0

Pulmonary Coccidioidomycosis Complicated by Nontuberculous Mycobacterial Pulmonary Diseases with a Literature Review. 肺球虫病并发非结核分枝杆菌性肺部疾病的文献复习。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-05-31 DOI: 10.7883/yoken.JJID.2023.073

Hiroki Ashizawa, Naoki Iwanaga, Hirokazu Kurohama, Yuya Ito, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Yohsuke Nagayoshi, Masato Tashiro, Takahiro Takazono, Tsutomu Tagawa, Kiyoyasu Fukushima, Masahiro Ito, Shigeki Nakamura, Koichi Izumikawa, Katsunori Yanagihara, Yoshitsugu Miyazaki, Hiroshi Mukae

{"title":"Pulmonary Coccidioidomycosis Complicated by Nontuberculous Mycobacterial Pulmonary Diseases with a Literature Review.","authors":"Hiroki Ashizawa, Naoki Iwanaga, Hirokazu Kurohama, Yuya Ito, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Yohsuke Nagayoshi, Masato Tashiro, Takahiro Takazono, Tsutomu Tagawa, Kiyoyasu Fukushima, Masahiro Ito, Shigeki Nakamura, Koichi Izumikawa, Katsunori Yanagihara, Yoshitsugu Miyazaki, Hiroshi Mukae","doi":"10.7883/yoken.JJID.2023.073","DOIUrl":"10.7883/yoken.JJID.2023.073","url":null,"abstract":"Following an endobronchial examination, a young mine supervisor was treated with antibiotics for a pulmonary nontuberculous mycobacterial infection for approximately one year. However, a review of the radiological findings revealed a different possibility. Accordingly, pulmonary resection was performed, and histopathological analysis revealed numerous yeast-like fungi. Since the patient had stayed in the southwestern United States for two months in 2009, eight years previously, coccidioidomycosis was strongly suspected. The diagnosis of coccidioidomycosis was subsequently confirmed by serology and polymerase chain reaction testing of the excised specimen. Here, we report an educational case that emphasizes the importance of meticulous medical history-taking and awareness of endemic mycoses in other countries in the context of globalization.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0