Prevalence of human adenovirus type 3 associated with pharyngoconjunctival fever in children in Osaka, Japan during and after the COVID-19 pandemic

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Mei Koyama, Satoshi Hiroi, Yuki Hirai, Atsushi Kaida
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引用次数: 0

Abstract

Since the COVID-19 pandemic has affected the epidemiological pattern of pharyngoconjunctival fever (PCF) caused by human adenovirus (HAdV), the prevalence and type distribution of HAdVs associated with PCF among children in Osaka, Japan, between 2019 and 2023 have been analyzed. The number of reported PCF cases in Osaka decreased from 2020 to 2022, followed by an unprecedented increase in 2023. HAdV-C strains, including types C1, C2, and C5, were annually detected in pathogen surveillance in Osaka. HAdV-B3 was not detected for 2 years and 9 months from March 2020, and the number of detections increased from July 2023. In total, HAdV-B3 was the most frequently detected (27 of 52 strains), and genetic analysis of its hexon hypervariable regions showed that, except for one strain, the HAdV-B3 strains identified after 2022 had different amino acid substitutions compared to those identified in 2019 and 2020. These results suggest that the PCF epidemic in 2023 was predominantly caused by variant strains of HAdV-B3, and children who have not acquired immunity against HAdV-B3 between 2020 and 2022 were thought to be infected. The impact of COVID-19 on the prevalence of HAdV infections needs to be continuously evaluated through surveillance.

在 COVID-19 大流行期间和之后,日本大阪儿童中与咽结膜炎相关的人类腺病毒 3 型的流行率
由于 COVID-19 大流行影响了由人类腺病毒(HAdV)引起的咽结膜热(PCF)的流行病学模式,因此我们对 2019 年至 2023 年期间日本大阪儿童中与 PCF 相关的 HAdV 的流行率和类型分布进行了分析。大阪报告的 PCF 病例数在 2020 年至 2022 年期间有所减少,但在 2023 年出现了前所未有的增长。在大阪的病原体监测中,每年都能检测到 HAdV-C 株,包括 C1、C2 和 C5 型。自 2020 年 3 月起,HAdV-B3 已有 2 年零 9 个月未被检测到,而自 2023 年 7 月起,检测次数有所增加。总的来说,HAdV-B3 是最常检测到的病毒(52 株中有 27 株),对其 hexon 超变异区的基因分析表明,除一株外,2022 年之后检测到的 HAdV-B3 株与 2019 年和 2020 年检测到的株相比,氨基酸替换不同。这些结果表明,2023年的PCF疫情主要是由HAdV-B3变异株引起的,2020年至2022年期间未获得HAdV-B3免疫力的儿童被认为受到了感染。COVID-19对HAdV感染率的影响需要通过监测进行持续评估。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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