Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand.

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2024-07-23 Epub Date: 2024-02-29 DOI:10.7883/yoken.JJID.2023.376
Chanihcha Anudit, Pornthip Saraisuwan, Chantana Kimterng, Chanakan Puangmanee, Nicharee Bamphensin, Anusak Kerdsin
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引用次数: 0

Abstract

Escherichia coli is a Gram-negative bacterium that causes a variety of clinical infections in humans, including diarrhea, sepsis, and urinary tract infection. This bacterium is a common multidrug-resistant threat in community and hospital settings worldwide. This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and enterobacterial repetitive intergenic consensus (ERIC)-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All isolates were susceptible to nitrofurantoin, and almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. High resistance rates to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole were observed. Clermont phylogroup B2 was predominant (n = 58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n = 11), VII (n = 9), III (n = 6), and II (n = 6) were most prevalent. ERIC-PCR showed that the strains of the B2 subgroups III and V were spread between provincial and community hospitals and between hospital wards. This evidence suggests the need for comprehensive infection control monitoring, with strong active surveillance at all hospital levels.

泰国中部乌泰他尼府医院和社区医院尿液大肠埃希氏菌 B2 群的传播。
大肠埃希菌是一种革兰氏阴性细菌,主要引起人类的各种临床感染,如腹泻、败血症和尿路感染。这种细菌是全球社区和医院环境中常见的耐多药威胁。本研究根据克莱蒙系统分型和 ERIC-PCR 对泰国省级医院和社区医院的 84 个大肠杆菌尿液分离株进行了抗菌药敏感性和遗传关系研究。所有分离菌株都对硝基呋喃妥因完全敏感,而几乎所有分离菌株都对碳青霉烯类、磷霉素和阿米卡星敏感。对氟喹诺酮、氨苄西林和三甲氧苄青霉素/磺胺甲噁唑的耐药率很高。克莱蒙特菌群 B2 是主要菌群(n=58)。对 B2 系统群进行亚型分析后发现了不同的亚群,其中以 V 亚群(11 人)为主,其次是 VII 亚群(9 人)、III 亚群(6 人)和 II 亚群(6 人)。ERIC-PCR 显示,B2 亚群 III 和 V 的菌株在省级医院和社区医院之间以及医院病房之间传播。这些证据表明,有必要进行全面的感染控制监测,并在各级医院开展强有力的主动监测。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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