Japanese journal of infectious diseases最新文献

Mpox in an immunocompromised patient: Fatal case report, Colombia. 一例免疫功能低下患者的麻疹：致命病例报告，哥伦比亚。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-05-30 DOI: 10.7883/yoken.JJID.2024.120

Sheryll Corchuelo Chavarro, Alicia Rosales Munar, Edgar Parra Saad, Cristian Arbey Velarde Hoyos, Idabely Betancur Ortiz, Orlando Torres-Fernandez, Lady Rivera, Diana Walteros, Franklyn Prieto, Marcela Mercado

{"title":"Mpox in an immunocompromised patient: Fatal case report, Colombia.","authors":"Sheryll Corchuelo Chavarro, Alicia Rosales Munar, Edgar Parra Saad, Cristian Arbey Velarde Hoyos, Idabely Betancur Ortiz, Orlando Torres-Fernandez, Lady Rivera, Diana Walteros, Franklyn Prieto, Marcela Mercado","doi":"10.7883/yoken.JJID.2024.120","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.120","url":null,"abstract":"Mpox is a viral zoonosis caused by the monkeypox virus (MPXV), a double-stranded DNA virus mostly transmitted by direct contact, respiratory droplets, and contaminated fomites. Immunodeficiency, younger age, chronic diseases, and lack of immunization are all associated with severe illness. Mpox was declared by the World Health Organization a Public Health Emergency of International Concern on May 20, 2022. This report aimed to provide a detailed histopathological and immunohistochemical findings of a fatal case of an immunosuppressed patient infected with MPXV, reported in Colombia in September 2022. A description of the clinical findings was made, followed by histopathological, immunohistochemical, and molecular studies to confirm the presence of MPXV genomes and viral antigens in different tissues. MPXV viral DNA of the clade IIb was identified, and MPXV genomes were found in the liver, lung, heart, and brain. Interestingly, MPXV antigens were observed in the skin and lung, mainly in necrotic areas surrounded by active inflammatory cell markers. The simultaneous use of several diagnostic tools, as histopathological, molecular and Next Generation Sequencing in fatal cases involving a variety of viral agents, provide relevant information to understand the pathogenesis and clarify the cause of death of this emerging infectious disease.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Report on the Measles Outbreak Case in a Medical Institution in South Korea, 2024. 2024年韩国某医疗机构麻疹暴发病例报告

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-05-30 DOI: 10.7883/yoken.JJID.2024.207

Soo Hyeon Cho, Eun Jung Jang, Joon Jai Kim, Mi-Gyeong Kim, Seonju Yi, Seung Eun Lee

{"title":"Report on the Measles Outbreak Case in a Medical Institution in South Korea, 2024.","authors":"Soo Hyeon Cho, Eun Jung Jang, Joon Jai Kim, Mi-Gyeong Kim, Seonju Yi, Seung Eun Lee","doi":"10.7883/yoken.JJID.2024.207","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.207","url":null,"abstract":"This report analyzes a measles outbreak that occurred at a medical institution (Hospital A) in Gyeonggi-do in April 2024, aiming to examine its epidemiological characteristics and derive implications for disease control policies. A cross-sectional study was conducted on 469 confirmed cases and contacts associated with Hospital A during the outbreak period using telephone interviews and on-site epidemiological investigations. Frequency analysis of epidemiological data was performed using statistical software. The attack rate related to the outbreak at Hospital A was 0.64%, with a secondary attack rate of 25.0%. The outbreak involved three confirmed measles cases, including one patient (index case) and two healthcare workers (secondary cases), all carrying the B3 genotype. In total, 469 individuals were exposed during the outbreak at Hospital A, including the three confirmed cases. The outbreak likely originated from a hospital visitor as the source of infection, with no additional transmission beyond hospital staff. To prevent transmission, prompt contact management, periodic antibody testing, and additional vaccinations for staff are recommended.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An invasive macrolide/lincosamide-resistant Corynebacterium mucifaciens isolate from a patient with diabetic gangrene: Colonies with mucoid appearance harboring a fragment of erm(X). 从糖尿病坏疽患者中分离出的侵袭性大环内酯/利可沙胺耐药黏液棒状杆菌：具有粘液样外观的菌落含有erm(X)片段。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-05-30 DOI: 10.7883/yoken.JJID.2025.034

Takumi Ebihara, Kyoko Baba, Haruno Yoshida, Yoneji Hirose, Mieko Goto, Takashi Takahashi

{"title":"An invasive macrolide/lincosamide-resistant Corynebacterium mucifaciens isolate from a patient with diabetic gangrene: Colonies with mucoid appearance harboring a fragment of erm(X).","authors":"Takumi Ebihara, Kyoko Baba, Haruno Yoshida, Yoneji Hirose, Mieko Goto, Takashi Takahashi","doi":"10.7883/yoken.JJID.2025.034","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.034","url":null,"abstract":"Corynebacterium mucifaciens, usually isolated from sterile human specimens, is a rare Corynebacterium species. We describe a blood-origin C. mucifaciens isolate that was resistant to macrolides/lincosamides and had been isolated from a patient with diabetic gangrene. This isolate formed mucoid colonies harboring a fragment of erm(X). As an initial antimicrobial, piperacillin/tazobactam was intravenously administered to the patient for two weeks. Gangrene debridement resulted in good local management. The clinical course was uneventful. The subculture from blood on a blood agar plate revealed mucoid colonies with a positive string test. Gram staining revealed the presence of a mucoid layer around the coryneform. The minimum inhibitory concentrations determined using broth microdilution method indicated resistance to erythromycin/clindamycin. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), 16S rRNA gene sequencing, and antimicrobial resistance (AMR) gene profiling were performed. MALDI-TOF-MS identified this isolate as C. mucifaciens based on its high score (2.22). 16S rRNA gene sequencing revealed 99.3% similarity with DMMZ 2278(T) 16S rRNA gene sequence. AMR gene profiling revealed that this isolate possessed a fragment identical to that of erm(X) from Actinotignum schaalii. MALDI-TOF-MS with 16S rRNA gene sequencing can be useful to identify C. mucifaciens when the coryneform shows a mucoid colony appearance with hyperviscosity.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated number of mumps cases based on clinical and laboratory data from sentinel surveillance in Kanazawa, Japan. 根据日本金泽哨点监测的临床和实验室数据估计的腮腺炎病例数。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-05-30 DOI: 10.7883/yoken.JJID.2024.331

Manami Nakashita, Hajime Kamiya, Reiji Watanabe, Yusuke Kobayashi, Yumani Kuba, Rie Koshida, Eri Nariai, Kiyosu Taniguchi, Shigeru Suga, Eiichi Kodama, Tomimasa Sunagawa, Motoi Suzuki

{"title":"Estimated number of mumps cases based on clinical and laboratory data from sentinel surveillance in Kanazawa, Japan.","authors":"Manami Nakashita, Hajime Kamiya, Reiji Watanabe, Yusuke Kobayashi, Yumani Kuba, Rie Koshida, Eri Nariai, Kiyosu Taniguchi, Shigeru Suga, Eiichi Kodama, Tomimasa Sunagawa, Motoi Suzuki","doi":"10.7883/yoken.JJID.2024.331","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.331","url":null,"abstract":"Currently, the mumps vaccine is not routinely recommended in Japan. Adding the mumps vaccine to the routine vaccination program requires an accurate estimation of the mumps viral infection disease burden. However, no precise estimate exists in Japan because mumps surveillance is sentinel surveillance with a reporting definition consisting of only a clinical diagnosis (parotid swelling). Since parotid swelling can be caused by pathogens other than the mumps virus, the estimation of mumps cases using the current surveillance data is inaccurate. To obtain an accurate burden of disease, we estimated the burden of the disease using the test results performed at a single sentinel site for laboratory-based surveillance during the mumps endemic (Week 14, 2015, to Week 13, 2016) in Kanazawa. The estimated number of mumps cases using laboratory-confirmed cases was 3,881 (95% confidence interval: 3,404-4,357), approximately 1,000 cases less than the estimated number using clinically compatible mumps cases. Although the estimated number of mumps cases using laboratory-confirmed cases was less than that of clinically compatible cases, the frequency of hearing loss due to mumps could potentially be 40% higher than that currently reported. To make the argument for routine mumps vaccination, surveillance using diagnostic testing information is important.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Draft genome sequence based genomic characterization of Salmonella enterica subsp. enterica serovar Oslo isolated from clinical samples in South India and its comparison with global isolates. 基于草图基因组序列的肠沙门氏菌亚种基因组鉴定。从南印度临床样本中分离的肠球菌奥斯陆血清型及其与全球分离株的比较。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-05-30 DOI: 10.7883/yoken.JJID.2024.406

Paulami Dutta, Gourab Halder, Manisha Ghosh, Beena Antony, Priyanka Denny, Arindam Ganai, Shanta Dutta

{"title":"Draft genome sequence based genomic characterization of Salmonella enterica subsp. enterica serovar Oslo isolated from clinical samples in South India and its comparison with global isolates.","authors":"Paulami Dutta, Gourab Halder, Manisha Ghosh, Beena Antony, Priyanka Denny, Arindam Ganai, Shanta Dutta","doi":"10.7883/yoken.JJID.2024.406","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.406","url":null,"abstract":"Non-typhoidal Salmonellae (NTS) are one of the significant food-borne pathogens with ≥2600 serovars and diverse range of hosts which significantly increases the chances of infections in humans. Salmonella enterica subsp. enterica serovar Oslo (S. Oslo) is a rare serovar, associated with foodborne illnesses. Here, we aim to report the draft whole genome sequences of S. Oslo ST2344 and ST1370 with reduced ciprofloxacin susceptibility, isolated from clinical samples. Thirty S. Oslo isolates were identified following the standard microbiological techniques. Twenty-six of the thirty (86.66%) S. Oslo isolates were pan-susceptible to the antimicrobials examined, except four isolates, which showed decreased ciprofloxacin susceptibility (MIC 0.12 - 0.50 µg/ml). PFGE analysis showed strains were heterogenous with two sequence types of ST1370 and ST2344 were observed in MLST. The average genome size of the four S. Oslo isolates ranged from 4,760,441 - 5,002,787 bp with average G+C content of 52 %. Different virulence genes encompassing Salmonella Pathogenicity Island (SPI) 1 to 5 linked to disease pathogenesis were found by genome analysis. The draft genome of S. Oslo clinical isolates gives an insight into the molecular characteristics of S. Oslo currently prevalent in India and the phylogenetic analysis sheds light on their evolutionary pattern.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial susceptibility and clinical phenotypes of Staphylococcus argenteus isolated from clinical specimens. 临床标本分离的阿根廷葡萄球菌的抗菌敏感性和临床表型。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-05-30 DOI: 10.7883/yoken.JJID.2025.067

Nobumasa Okumura, Nana Akazawa-Kai, Haruka Tsukamoto, Naoya Itoh

{"title":"Antimicrobial susceptibility and clinical phenotypes of Staphylococcus argenteus isolated from clinical specimens.","authors":"Nobumasa Okumura, Nana Akazawa-Kai, Haruka Tsukamoto, Naoya Itoh","doi":"10.7883/yoken.JJID.2025.067","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.067","url":null,"abstract":"Recently, Staphylococcus argenteus, previously indistinguishable from Staphylococcus aureus, has been recognized as a clinically relevant microorganism because of mass spectrometry. However, despite its clinical significance, limited information is available on S. argenteus. This study evaluated the antimicrobial susceptibility and clinical phenotypes of S. argenteus isolated from clinical specimens. This single-center, retrospective study analyzed cases wherein S. argenteus was detected in clinical specimens obtained at Nagoya City University East Medical Center between April 2023 and April 2024. The organism was identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Patient data, including clinical outcomes, were collected and reviewed to classify cases as infections or colonization. S. argenteus was isolated from 23 specimens of 21 patients, with sputum being the most common source (78.3%). Sixty-seven percent of isolates were susceptible to penicillin; 95.2% to erythromycin; and 100% to oxacillin, clindamycin, sulfamethoxazole-trimethoprim, vancomycin, and teicoplanin. Thirteen cases of infection were recorded; pneumonia was the predominant diagnosis (11 cases) in these cases, followed by otitis externa and vertebral osteomyelitis. Most patients were successfully treated with antibiotics, and only one died of S. argenteus pneumonia.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and factors associated with HIV virologic failure among adults on first-line antiretroviral therapy: A five-year retrospective study in Thailand. 在泰国，一线抗逆转录病毒治疗的成人中HIV病毒学失败的发病率和相关因素：一项为期五年的回顾性研究。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-04-30 DOI: 10.7883/yoken.JJID.2023.409

Lantharita Charoenpong, Chalor Santiwarangkana, Weerawat Manosuthi

{"title":"Incidence and factors associated with HIV virologic failure among adults on first-line antiretroviral therapy: A five-year retrospective study in Thailand.","authors":"Lantharita Charoenpong, Chalor Santiwarangkana, Weerawat Manosuthi","doi":"10.7883/yoken.JJID.2023.409","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2023.409","url":null,"abstract":"Virologic failure and HIV drug resistance have emerged with the widespread use of antiretroviral therapy (ART). Understanding these predictors is the basis for prevention strategies to achieve a high treatment success rate. A retrospective cohort study was conducted among antiretroviral-naïve people living with HIV (PLWH) registered in the national AIDS program database of the National Health Security Office Region 4 between January 2014 and December 2018. To determine the cumulative incidence rate of virologic failure and related factors, all PLWHs were monitored for viral load status through December 2019. Virologic failure was defined as HIV viral load >1,000 copies/mL after 6 months of ART. Of the 42,229 PLWHs identified, 10,211 PLWHs with primary ART regimens and follow-up data were included. There were 67.1% males, and the mean age was 35 years (SD 11.6). During the median observation period of 0.88 (IQR 0.23-1.94) years after ART initiation, 2.4% (242/10,211) of the PLWH experienced virologic failure. The Cox proportional hazard model revealed that the risk of developing virologic failure was significantly associated with age < 30 years and baseline CD4 cell count ≤ 200 cells/mm 3 . Active case finding, early ART initiation, and strengthening of the HIV continuum of care intervention are strongly recommended to prevent and reduce treatment failure.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative hepatitis C screening: Clinical utility of the HCV antigen-antibody assay in Japan. 创新丙型肝炎筛查：HCV抗原抗体测定在日本的临床应用

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-04-30 DOI: 10.7883/yoken.JJID.2025.032

Takako Inoue, Hiroko Setoyama, Takehisa Watanabe, Takanori Suzuki, Katsuya Nagaoka, Etsuko Iio, Kentaro Matsuura, Yasuhito Tanaka

{"title":"Innovative hepatitis C screening: Clinical utility of the HCV antigen-antibody assay in Japan.","authors":"Takako Inoue, Hiroko Setoyama, Takehisa Watanabe, Takanori Suzuki, Katsuya Nagaoka, Etsuko Iio, Kentaro Matsuura, Yasuhito Tanaka","doi":"10.7883/yoken.JJID.2025.032","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.032","url":null,"abstract":"The Elecsys® HCV Duo (HCV Duo) detects anti-HCV antibodies (Duo/anti-HCV) and HCV core antigen (Duo/HCV-Ag), offering an efficient, cost-effective, and rapid HCV screening. We evaluated HCV Duo's utility in Japan. We analyzed 373 samples (120 HCV RNA-detectable and 253 HCV RNA-undetectable) from chronic hepatitis C (CHC) patients. Duo/anti-HCV sensitivity was assessed using conventional assays. Duo/HCV-Ag sensitivity and specificity were evaluated based on HCV RNA levels. 153 untreated CHC patients at Nagoya City University Hospital (NCUH) between 2019 and 2023 were categorized by HCV RNA levels. HCV Duo showed 100% sensitivity (373/373) for Duo/anti-HCV and 99.2% specificity (251/253) for Duo/HCV-Ag in resolved infection. Duo/HCV-Ag exhibited 55.0% sensitivity (66/120) in active HCV infections. For HCV RNA levels ≤4.0, 4.1-5.5, and ≥5.6 log IU/mL, Duo/HCV-Ag detection rates were 20.5% (9/44), 33.3% (7/21), and 87.3% (48/55), respectively. At NCUH, 71.2% (109/153) of patients had HCV RNA levels ≥5.6 log IU/mL, while 2.6% (4/153) and 26.1% (40/153) had levels ≤4.0 and 4.1-5.5 log IU/mL, respectively. Duo/HCV-Ag performance improves with higher HCV RNA levels, particularly ≥5.6 log IU/mL. HCV RNA testing is recommended for patients positive for Duo/anti-HCV but negative for Duo/HCV-Ag. Duo/HCV-Ag-positive patients should be referred to hepatologists for further evaluation and treatment.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorous acid inactivates Mycobacterium tuberculosis with much lower available chlorine concentration than sodium hypochlorite. 氯酸灭活结核分枝杆菌的有效氯浓度比次氯酸钠低得多。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-04-30 DOI: 10.7883/yoken.JJID.2024.284

Noritoshi Hatanaka, Sharda Prasad Awasthi, Hisataka Goda, Hiroyuki Kawata, Atsushi Hinenoya, Shinji Yamasaki

{"title":"Chlorous acid inactivates Mycobacterium tuberculosis with much lower available chlorine concentration than sodium hypochlorite.","authors":"Noritoshi Hatanaka, Sharda Prasad Awasthi, Hisataka Goda, Hiroyuki Kawata, Atsushi Hinenoya, Shinji Yamasaki","doi":"10.7883/yoken.JJID.2024.284","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.284","url":null,"abstract":"Mycobacterium tuberculosis is the causative agent of tuberculosis. Globally it is one of the most important bacteria responsible for human mortality. To control tuberculosis proper sterilization of Mycobacterium is important. For sterilization of pathogens, sodium hypochlorite is commonly used. However, M. tuberculosis usually shows high resistance against sodium hypochlorite. In this study, we compared the bactericidal activity of chlorous acid and sodium hypochlorite against M. tuberculosis in the presence or absence of artificial saliva. When 7.0 log CFU/mL of M. tuberculosis was treated with different concentrations of sodium hypochlorite or chlorous acid, it was found that while 20,000 ppm of sodium hypochlorite was needed to reduce the pathogen below the detection limit but for chlorous acid only 5 ppm was required. Furthermore, when the experiment was performed in the presence of artificial saliva, 500 ppm of sodium hypochlorite was needed to reduce the M. tuberculosis below detection limit but for chlorous acid it was 25 ppm. The data indicate that chlorous acid is a more powerful disinfectant than sodium hypochlorite regardless of presence or absence of artificial saliva. Thus, chlorous acid may be used as a useful bactericidal agent to sterilize clinical environment contaminated with M. tuberculosis.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiological characteristics and drug resistance rates of Candida auris isolates in Japan. 日本金黄色念珠菌分离株微生物学特征及耐药率。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-31 DOI: 10.7883/yoken.JJID.2025.025

Masahiro Abe, Ami Koizumi, Takashi Umeyama, Hiroko Tomuro, Yasunori Muraosa, Nobuko Nakayama, Sayoko Oiki, Satoshi Shimada, Yuko Murakami, Masayuki Ota, Itsuro Yoshimi, Azusa Takahashi, Takashi Ono, Masaru Sasaki, Eri Uchida-Fujii, Manami Nakashita, Hitomi Kurosu, Takuya Yamagishi, Takayuki Shinohara, Yasutaka Hoshino, Yoshitsugu Miyazaki

{"title":"Microbiological characteristics and drug resistance rates of Candida auris isolates in Japan.","authors":"Masahiro Abe, Ami Koizumi, Takashi Umeyama, Hiroko Tomuro, Yasunori Muraosa, Nobuko Nakayama, Sayoko Oiki, Satoshi Shimada, Yuko Murakami, Masayuki Ota, Itsuro Yoshimi, Azusa Takahashi, Takashi Ono, Masaru Sasaki, Eri Uchida-Fujii, Manami Nakashita, Hitomi Kurosu, Takuya Yamagishi, Takayuki Shinohara, Yasutaka Hoshino, Yoshitsugu Miyazaki","doi":"10.7883/yoken.JJID.2025.025","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.025","url":null,"abstract":"Candida auris (C. auris) was initially isolated from a Japanese patient, and this species is an emerging fungus nowadays owing to its long-term colonization capabilities and high resistance to antifungal drugs. However, accurate domestic epidemiology of C. auris remains unknown. We here collected C. auris isolates reported from hospitals, public health centers, and public health institutes based on the administrative liaison. Moreover, we collected stocked C. auris isolates from three nongovernmental laboratory companies. Seventy C. auris isolates were collected during the study period. C. auris isolates predominantly originated from ear discharge clinical samples. Clade determination based on ITS-D1/D2 regions and CauMT1 locus revealed that almost all isolates belonged to clade II; however, one ear discharge-derived isolate belonged to clade I. Whole genome sequencing also confirmed this clade I C. auris isolate. Regarding drug susceptibilities, 20% of isolates were resistant to fluconazole; however, no isolates exhibited polyene or echinocandin resistance. Therefore, C. auris isolates in Japan were generally derived from ear discharges and belonged to clade II. However, ear discharge-derived isolates may not exclusively belong to clade II. Although no invasive cases were reported during the study period, continuing surveillance program for describing clear domestic epidemiology would be necessary.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0