Japanese journal of infectious diseases最新文献

Evaluation of Mumps-specific Neutralizing Antibody Compared to Immunoglobulin G Antibody in Japanese Children After the Coronavirus Disease Pandemic. 冠状病毒大流行后日本儿童流行性腮腺炎特异性中和抗体与免疫球蛋白G抗体的比较

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.286

Tomohiro Oishi, Kazuho Maeda, Saeko Morikawa, Takashi Nakano

{"title":"Evaluation of Mumps-specific Neutralizing Antibody Compared to Immunoglobulin G Antibody in Japanese Children After the Coronavirus Disease Pandemic.","authors":"Tomohiro Oishi, Kazuho Maeda, Saeko Morikawa, Takashi Nakano","doi":"10.7883/yoken.JJID.2025.286","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.286","url":null,"abstract":"Mumps vaccination, which is routinely administered in many countries, is not covered by Japan's national immunization program. Therefore, mumps epidemic occurs every 3 or 4 years in Japan due to a low vaccine coverage rate. To prepare for the next resurgence, we examined the immunity against mumps using neutralizing antibodies (NT) against vaccine strain (genotype B) and wildtype virus (genotype G), and mumps-specific enzyme immunoassay for immunoglobulin G (IgG). We enrolled 83 children admitted to the Kawasaki Medical Hospital for diseases other than mumps between April and December 2022. The positive rates of NT for both of wild type and vaccine type were lower (25 .3%) than that of IgG (38.5%). No significant difference among them. Though individual infection histories were not confirmed, the absence of any mumps epidemic during the coronavirus disease pandemic, Therefore, almost all enrolled children were unlikely to have been infected with mumps, that is, they might have acquired immunity only by voluntary vaccinations. Therefore, we evaluate the immunity for mumps in the real world at three novel points as follows, (1) to evaluate under non-national immunization program (2) to evaluate Hoshino vaccine strains (3) to evaluate both IgG and the other immunity.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Questionnaire-based analysis of infection control and prevention strategies against COVID-19 in hematopoietic stem cell transplantation units in Japan, 2023. 2023年日本造血干细胞移植单位COVID-19感染控制及预防策略问卷分析

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.231

Takashi Sakoh, Masayo Morishima, Tadaki Suzuki, Naoyuki Uchida, Hideki Araoka

{"title":"Questionnaire-based analysis of infection control and prevention strategies against COVID-19 in hematopoietic stem cell transplantation units in Japan, 2023.","authors":"Takashi Sakoh, Masayo Morishima, Tadaki Suzuki, Naoyuki Uchida, Hideki Araoka","doi":"10.7883/yoken.JJID.2025.231","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.231","url":null,"abstract":"There is no clear consensus regarding the optimal strategy for preventing the spread of COVID-19 among hematopoietic stem cell transplantation (HSCT) units. We conducted a questionnaire survey of 16 Japanese HSCT units in the greater Tokyo area to investigate the actual infection control strategies for COVID-19 implemented during 2023. Four facilities (25.0%) conducted active screening tests when patients were admitted to the HSCT unit. Regarding the admission of recipients with a history of COVID-19, 10 facilities (62.5%) had no clearly defined rules; instead, decisions were made based on factors such as the patient's symptoms, the local epidemic situation, clinical course, and absence of pneumonia. For current COVID-19 cases, 9 facilities (56.3%) set the standard isolation periods based on the number of days from the onset of symptoms. Microbiological retest results were used as a reference at 11 facilities (68.8%), and 6 facilities considered extended isolation periods with the retest results. Seven facilities (43.8%) implemented additional extended isolation management for recovered recipients who still required hospitalization. Although little is known about vulnerability to SARS-CoV-2 among HSCT recipients and there is potential selection bias due to the small sample size, this summary serves as a reference for reviewing infection control strategies.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An outbreak of acute respiratory illness caused by human rhinovirus species C in facilities for persons with severe motor and intellectual disabilities. 由人类鼻病毒C种引起的急性呼吸道疾病在严重运动及智力残疾人士的设施中爆发。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2024.308

Rina Kubota, Hiroyuki Tsukagoshi, Ryo Shimada, Yuki Nakazawa, Yuri Shinohara, Akio Saito, Fumitaka Inoue, Tsuyoshi Nakano, Nobuhiro Saruki

{"title":"An outbreak of acute respiratory illness caused by human rhinovirus species C in facilities for persons with severe motor and intellectual disabilities.","authors":"Rina Kubota, Hiroyuki Tsukagoshi, Ryo Shimada, Yuki Nakazawa, Yuri Shinohara, Akio Saito, Fumitaka Inoue, Tsuyoshi Nakano, Nobuhiro Saruki","doi":"10.7883/yoken.JJID.2024.308","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.308","url":null,"abstract":"Human rhinovirus (HRV) commonly causes mild respiratory illness but may occasionally result in severe disease requiring hospitalization. Herein, we report a respiratory outbreak at a residential hospital for individuals with severe motor and intellectual disabilities (SMID) where HRV was detected. The facility housed 47 residents, 31 of whom developed symptoms. Further, 20 symptomatic patients were tested, and HRV-C was detected in 15 of them using RT-PCR. The nucleotide identity of the detected strains was 100%, and based on phylogenetic analysis, the strain was identified as the HRV-C56 type. No other pathogens were detected. Although the specific mode of transmission remains unclear, the patients had been residing at the facility for an extended period of time with limited mobility. Therefore, healthcare workers or visitors may have been the source of infection. In this outbreak, HRV-C disseminated rapidly among the residents, resulting in the spread of infections to healthcare workers and affecting healthcare. It is imperative for medical institutions, particularly long-term care facilities, to establish systems for the early detection and management of respiratory infections.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyses of two decades of community-onset pneumonia cases with respiratory viral infections, including respiratory syncytial virus, in adults in a community hospital in Japan. 日本一家社区医院20年社区发病的成人呼吸道病毒感染（包括呼吸道合胞病毒）肺炎病例分析

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.244

Hiroshi Takahashi, Kosuke Sato, Takehiro Yajima, Daisuke Jingu, Satoshi Ubukata, Hiroshi Watanabe, Hidekazu Nishimura

{"title":"Analyses of two decades of community-onset pneumonia cases with respiratory viral infections, including respiratory syncytial virus, in adults in a community hospital in Japan.","authors":"Hiroshi Takahashi, Kosuke Sato, Takehiro Yajima, Daisuke Jingu, Satoshi Ubukata, Hiroshi Watanabe, Hidekazu Nishimura","doi":"10.7883/yoken.JJID.2025.244","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.244","url":null,"abstract":"Information regarding the disease burden of respiratory syncytial virus (RSV) infection among the elderly in Japan is limited. A comprehensive review of the medical records from January 1, 2002, to December 31, 2023, was conducted for adult cases of community-onset pneumonia encountered in routine clinical practice at a community hospital in Shiogama, Japan. The pneumonia case definition employed in this study, for pathogens including major respiratory viruses, required laboratory diagnosis supported by solid virological data, such as virus isolation or rising antibody titers, rather than merely gene detection. The results indicated that, before the emergence of the Coronavirus disease-2019 pandemic in 2020, RSV and influenza virus infections accounted for a substantial proportion (30% each) of the detected respiratory viruses, and RSV persisted as the second most prevalent virus, surpassed only by Severe Acute Respiratory Syndrome Coronavirus-2, even after the pandemic emerged. The mortality rate associated with RSV as a prognostic factor reached 5-10%, depending on the period. The temporal pattern of case emergence from June 2011 to March 2025 suggested that community-acquired RSV infections in children likely precede the occurrence of RSV pneumonia in adults.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evaluation of Zika virus susceptibility in Aedes (Ochlerotatus) japonicus from Hokkaido, Japan. 日本北海道纹伊蚊对寨卡病毒的敏感性评价。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.269

Leo Uchida, Kana Iwamoto, Shino Kawae, Makoto Shimooka, Ronald Enrique Morales-Vargas, Yuki Eshita, Yasuko Orba, Hirofumi Sawa, Yasukazu Muramatsu

{"title":"The Evaluation of Zika virus susceptibility in Aedes (Ochlerotatus) japonicus from Hokkaido, Japan.","authors":"Leo Uchida, Kana Iwamoto, Shino Kawae, Makoto Shimooka, Ronald Enrique Morales-Vargas, Yuki Eshita, Yasuko Orba, Hirofumi Sawa, Yasukazu Muramatsu","doi":"10.7883/yoken.JJID.2025.269","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.269","url":null,"abstract":"Zika virus (ZIKV) is a mosquito-borne orthoflavivirus that causes acute symptoms, such as fever and conjunctivitis. Aedes (Stegomyia) aegypti and Ae. (Stg.) albopictus are the primary and secondary vectors, respectively, although other Aedes species may also transmit ZIKV. Aedes (Ochlerotatus) japonicus, native to East Asia, has recently spread to North America and Europe; however, its potential in ZIKV transmission, particularly in Japanese populations, remains unclear. In our previous study, a low viral titer of ZIKV was detected in a single virus-challenged Ae. japonicus individual. In the present study, we increased the sample size and compared infection rates and viral titers among Ae. japonicus, Ae. aegypti, and Ae. albopictus following exposure to the ZIKV strain MR766. Cumulative infection rates of Ae. japonicus (18%) were lower than those of Ae. aegypti (71%) and Ae. albopictus (67%). Nonetheless, some Ae. japonicus individuals had higher viral titers than the challenge dose, indicating efficient replication. ZIKV RNA was also detected in 14% of the saliva samples at 10 days post-infection. These findings suggested that the Japanese population of Ae. japonicus could potentially serve as a vector.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multilevel Determinants of COVID-19 Fear in South Korea: Examining the Interplay of Individual and Community-Level Factors. 韩国对COVID-19恐惧的多层决定因素：检查个人和社区层面因素的相互作用。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.213

Hohyun Seong, Sunyeob Choi, Sungwon Lim

{"title":"Multilevel Determinants of COVID-19 Fear in South Korea: Examining the Interplay of Individual and Community-Level Factors.","authors":"Hohyun Seong, Sunyeob Choi, Sungwon Lim","doi":"10.7883/yoken.JJID.2025.213","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.213","url":null,"abstract":"The global COVID-19 pandemic caused substantial psychological burden, resulting in a 25% increase in the prevalence of anxiety and depressive disorders worldwide. This study examined factors associated with the multifaceted fear of COVID-19 among South Korean adults, providing crucial insights for culturally tailored public health interventions. We utilized a cross-sectional secondary data analysis from the 2022 Korea Community Health Survey (n = 228,470) and the Korean Statistical Information Service. Using multilevel linear regression, we evaluated three pre-specified primary community-level hypotheses: the proportion of one-person households, the density of internal medicine clinics by jurisdiction, and unmet healthcare needs. Results revealed that a higher proportion of one-person households correlated with increased fear, while a greater density of internal medicine clinics by jurisdiction was linked to reduced fear. To estimate these community-level associations, we adjusted for individual-level covariates. Exploratory analyses of these covariates suggested that factors such as female sex, older age, higher education, living with a spouse, economic activity, and better self-rated health were associated with heightened COVID-19 fear. These findings emphasize the need for culturally sensitive mental health support, community-based initiatives, and strategic healthcare resource allocation in Asian communities to strengthen resilience during future health crises.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serological Diagnosis of The Smooth Brucella spp., Brucella canis, and Francisella tularensis in Patients with Overlapping Clinical Features. 临床特征重叠的光滑型布鲁氏菌、犬布鲁氏菌和土拉弗朗西斯菌的血清学诊断。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.233

Sevil Erdenliğ Gürbilek, Tuba Kayman, Ayfer Güllü Yücetepe, Doğancan Yarım, Çiğdem Eda Balkan Bozlak, Fatih Büyük, Fuat Aydın

{"title":"Serological Diagnosis of The Smooth Brucella spp., Brucella canis, and Francisella tularensis in Patients with Overlapping Clinical Features.","authors":"Sevil Erdenliğ Gürbilek, Tuba Kayman, Ayfer Güllü Yücetepe, Doğancan Yarım, Çiğdem Eda Balkan Bozlak, Fatih Büyük, Fuat Aydın","doi":"10.7883/yoken.JJID.2025.233","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.233","url":null,"abstract":"This study aimed to serologically diagnose Brucella spp. and Francisella tularensis in patients presenting with overlapping clinical symptoms. A total of 467 serum samples were tested for antibodies against smooth Brucella spp., Brucella canis, and F. tularensis using Rose Bengal Plate Test (RBPT), Serum Agglutination Test (SAT), Microagglutination Test (MAT), and indirect ELISA (iELISA). Seropositivity for smooth Brucella spp. was 12.85% (60/467) by RBPT/SAT and 10.06% (47/467) by iELISA, with moderate agreement (κ = 0.505). The diagnostic titer-based (sole) seropositivity rate was 9.85% (46/467). For B. canis, seropositivity was 5.14% (24/467) by RBPT and 3.64% (17/467) by iELISA, showing substantial agreement (κ = 0.715). The sole seropositivity rate was 3.64% (17/467). For F. tularensis, both MAT and iELISA showed 3.64% (17/467) seropositivity, with moderate agreement (κ = 0.561), while the sole seropositivity rate was 3.43% (16/467). Co-seropositivity was observed in 1.07% (n= 5) of samples between B. canis RBPT and smooth Brucella iELISA, and in 4.07% (n= 19) between smooth Brucella spp. and F. tularensis. One sample (0.21%) was noteworthy, suggesting possible co-infection. These findings confirm the regional presence of brucellosis and tularemia and highlight the value of combining serological methods in patients with non-specific symptoms and low antibody titers.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Septic Arthritis of the Left Ankle Caused by Brucella suis biovar 5: A Case Report. 猪布鲁氏菌生物型5致左踝关节脓毒性关节炎1例报告。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.274

Tatsuya Natori, Takehisa Matsumoto, Ayaka Hachiro, Yo Kitamura, Tomoya Iwaasa, Shunsuke Miyaoka, Jun Takahashi, Michio Suzuki, Koichi Imaoka, Ken Maeda, Tomoyuki Uno, Mizue Eita, Eri Uchida-Fujii, Hirofumi Kato, Tomoe Shimada, Kazuki Horiuchi, Tomu Kamijo, Taku Yamane, Shinichiro Kanai, Nau Ishimine, Takeshi Uehara

{"title":"Septic Arthritis of the Left Ankle Caused by Brucella suis biovar 5: A Case Report.","authors":"Tatsuya Natori, Takehisa Matsumoto, Ayaka Hachiro, Yo Kitamura, Tomoya Iwaasa, Shunsuke Miyaoka, Jun Takahashi, Michio Suzuki, Koichi Imaoka, Ken Maeda, Tomoyuki Uno, Mizue Eita, Eri Uchida-Fujii, Hirofumi Kato, Tomoe Shimada, Kazuki Horiuchi, Tomu Kamijo, Taku Yamane, Shinichiro Kanai, Nau Ishimine, Takeshi Uehara","doi":"10.7883/yoken.JJID.2025.274","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.274","url":null,"abstract":"We report a rare case of human brucellosis caused by Brucella suisbiovar 5 in a 75-year-old man from Nagano Prefecture, Japan. He had no history of immune disorders and presented with fatigue, left ankle pain, and swelling. Initial antimicrobial therapy for suspected cellulitis and tenosynovitis failed, leading to admission to our hospital. Imaging and synovial fluid analysis suggested septic arthritis with a periarticular abscess. Gram-negative rods were recovered from synovial fluid obtained via arthrocentesis of the left ankle joint. Although the isolate could not be identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a MALDI Biotyper system, it was successfully identified as B. suisbiovar 5 using species-specific PCR and nine-locus multilocus sequence typing (MLST). The patient was successfully treated with surgical debridement and prolonged antimicrobial therapy. This is the third documented human case of B. suisbiovar 5 infection in Japan, all originating from Nagano Prefecture, suggesting a localized cluster. This case highlights the diagnostic challenges of brucellosis, the limitations of routine identification methods, and the biosafety concerns for clinical laboratories. Enhanced awareness and surveillance are warranted in regions with emerging cases.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenicity of influenza split vaccine for 2025/26 season in Japan using a mouse model. 日本2025/26季节流感分离疫苗的小鼠模型免疫原性

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2025.278

Ryuichi Sugiyama, Kayoko Sato, Toru Takenaga, Hiyori Okura, Yusuke Nakai, Keiko Murano, Edna Sze Wai Lui, Emi Ito, Hideki Asanuma, Eita Sasaki, Seiichiro Fujisaki, Miki Akimoto, Aya Sato, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Shigeyuki Itamura, Yuichi Harada, Noriko Shimasaki

{"title":"Immunogenicity of influenza split vaccine for 2025/26 season in Japan using a mouse model.","authors":"Ryuichi Sugiyama, Kayoko Sato, Toru Takenaga, Hiyori Okura, Yusuke Nakai, Keiko Murano, Edna Sze Wai Lui, Emi Ito, Hideki Asanuma, Eita Sasaki, Seiichiro Fujisaki, Miki Akimoto, Aya Sato, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Shigeyuki Itamura, Yuichi Harada, Noriko Shimasaki","doi":"10.7883/yoken.JJID.2025.278","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.278","url":null,"abstract":"Seasonal influenza viruses continuously evolve, and the composition of the seasonal influenza vaccine is reviewed by the World Health Organization twice a year due to antigenic drift in the viral hemagglutinin (HA) protein. A timely assessment of how well vaccine-induced antibodies react to circulating viruses remains warranted. Here, immunogenicity of reference split vaccines for the 2025/26 season in Japan was analyzed in a mouse model using a microneutralization (MN) antibody assay against circulating A(H1N1)pdm09, A(H3N2), and B/Victoria-lineage viruses. In Japan, the vaccine used in the 2025/26 season consisted of three virus strains: A/Victoria/4897/2022 (IVR-238) (H1N1)pdm09, A/Perth/722/2024 (IVR-262) (H3N2), and B/Austria/1359417/2021 (BVR- 26). Reduced MN reactivity was observed against the tested circulating viruses, including A/Tokyo/EIS11-980/2025 (H1N1)pdm09 (HA subclade D.3.1), A/Tokyo/EIS13-029/2025 (H3N2) (HA subclade J.2.3), A/Tokyo/EIS13-355/2025 (H3N2) (HA subclade K), and B/Kanagawa/AC2414/2025 (B/Victoria lineage, HA subclade C3.1), with MN titers at least four-fold lower than those for the corresponding vaccine strains. These isolates had several amino acid substitutions at the antigenic or glycosylation sites in HA compared to the vaccine strains. These findings provide early laboratory indication of decreased immunogenicity of the vaccine against specific circulating viruses during the 2025/26 season in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Human Metapneumovirus-Related Acute Respiratory Infections in Children - A Four-Year Single Center Retrospective Study. 儿童人偏肺病毒相关急性呼吸道感染的特征——一项为期四年的单中心回顾性研究

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-04-30 DOI: 10.7883/yoken.JJID.2026.015

Sevliya Öcal Demir, Seyhan Yılmaz, Aylin Dizi Işık, Meryem Çağla Abacı Çapar, Sıla Cura, Rabia Dedeoğlu, Murat Yaman, Arzu İlki, Gülşen Akkoç

{"title":"Characteristics of Human Metapneumovirus-Related Acute Respiratory Infections in Children - A Four-Year Single Center Retrospective Study.","authors":"Sevliya Öcal Demir, Seyhan Yılmaz, Aylin Dizi Işık, Meryem Çağla Abacı Çapar, Sıla Cura, Rabia Dedeoğlu, Murat Yaman, Arzu İlki, Gülşen Akkoç","doi":"10.7883/yoken.JJID.2026.015","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.015","url":null,"abstract":"This study aimed to increase the data on characteristics and predictors of pediatric hMPV infection severity. Children admitted with ARI symptoms between 2021 and 2025 and diagnosed with hMPV by molecular testing were included. Seventy-eight children were included, of whom 48.7% were female. Most admissions occurred during winter and spring (92.3%). The median age was 14.9 months (IQR, 7.5-54.7), and 84.6% were younger than 5 years. At least one underlying comorbidity was present in 41% of patients, most commonly chronic lung disease. Major symptoms were cough (83.1%), rhinorrhea (61%), fever (59.2%), and stridor (41.6%), and tachypnea/dyspnea was observed in 31.2%. Median leukocyte count was 10,020/mm³ (IQR, 6,200-13,860), and median C-reactive protein level was 7.5 mg/dL (IQR, 1.1-26). Infiltration on chest radiographic (58.7%) were predominantly reticulonodular. About half of the patients (55.1%) required hospitalization; 21.8% needed respiratory support, and 6.4% were admitted to the pediatric intensive care unit. The need for respiratory support was significantly higher in children with comorbidities (p = 0.025), mortality was 2.6%. HMPV is a significant cause of ARIs in small children, particularly during winter and spring. Underlying comorbidities are associated with increased disease severity.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0