Japanese journal of infectious diseases最新文献

Non-woven masks and SARS-CoV-2 infection in a cluster setting in Japan.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-29 DOI: 10.7883/yoken.JJID.2023.059

Yukari Takahashi, Soshi Takao, Tomoka Kadowaki, Naomi Matsumoto, Takashi Yorifuji

{"title":"Non-woven masks and SARS-CoV-2 infection in a cluster setting in Japan.","authors":"Yukari Takahashi, Soshi Takao, Tomoka Kadowaki, Naomi Matsumoto, Takashi Yorifuji","doi":"10.7883/yoken.JJID.2023.059","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2023.059","url":null,"abstract":"Evidence about which types of mask are effective in preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We examined which mask types were effective against SARS-CoV-2 infection in a cluster setting in Japan. We retrospectively reviewed data from a cluster of COVID-19 cases that occurred at a manufacturing company in mid-August 2021. We included a total of 87 individuals who reported the type of mask worn. We dichotomized the types of mask into non-woven masks or other types of mask, such as cloth or urethane masks. We then examined the associations between the mask type and SARS-CoV-2 infection using logistic regression analysis, adjusting for potential confounders. Participants who wore non-woven masks were less likely to be infected with SARS-CoV-2 (9.7%) compared with those who wore other types of mask (26.7%). After adjusting for potential confounders, wearing a non-woven mask was significantly associated with a reduced risk of infection compared with wearing other mask types (odds ratio = 0.10, 95% confidence interval: 0.01 to 0.80). Non-woven masks were found to be more effective in preventing SARS-CoV-2 infection in a cluster setting than other types of mask, such as cloth or urethane masks.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of human coronavirus-OC43 in nasopharyngeal swab specimens via immunofluorescence staining using human serum and an anti-human antibody.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-29 DOI: 10.7883/yoken.JJID.2024.001

Mutsuo Yamaya, Oshi Watanabe, Yuki Kitai, Yusuke Sayama, Suguru Ohmiya, Hidekazu Nishimura

{"title":"Detection of human coronavirus-OC43 in nasopharyngeal swab specimens via immunofluorescence staining using human serum and an anti-human antibody.","authors":"Mutsuo Yamaya, Oshi Watanabe, Yuki Kitai, Yusuke Sayama, Suguru Ohmiya, Hidekazu Nishimura","doi":"10.7883/yoken.JJID.2024.001","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.001","url":null,"abstract":"Immunofluorescence methods to detect seasonal human coronavirus (HCoV)-OC43 in nasopharyngeal swab specimens using cell lines have not yet been established. A human rectal adenocarcinoma cell line (HRT-18) was exposed to the specimens obtained from patients with upper respiratory tract infections. Immunofluorescence staining was conducted with the combination of human serum containing the HCoV-OC43 anti-spike protein antibody and a fluorescence-labeled anti-human antibody. Positive staining in HRT-18 cells was detected after exposure to specimens obtained from nine of the eleven patients in which HCoV-OC43 RNA was detected using the FilmArray method. Increased supernatant viral RNA levels were also detected in HRT-18 cells exposed to specimens obtained from four of five patients. In contrast, positive staining was not detected in HRT-18 cells exposed to six patient specimens that tested negative for RNA from seventeen types and subtypes of respiratory viruses, including HCoV-OC43. The cells inoculated with the established strain HCoV-OC43 (ATCC VR-759) also showed positive staining. These findings suggest that the replication-competent HCoV-OC43 in the specimens could be detected via immunofluorescence staining of HRT-18 cells with human serum. It may be possible to obtain positive staining for viruses other than HCoV-OC43 using this method.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic, phylogenetic, and serological analysis of a Getah virus strain isolated from Culex tritaeniorhynchus mosquitoes in Nagasaki, Japan in 2022.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-29 DOI: 10.7883/yoken.JJID.2024.250

Ryo Matsumura, Hiroshi Bannai, Manabu Nemoto, Yukiko Higa, Izumi Kai, Toshinori Sasaki, Kyoko Futami, Akira Yoshikawa, Ryosuke Fujita, Masato Hino, Kosuke Nagata, Ryusei Kuwata, Yoshihiro Kaku, Daisuke Kobayashi, Noboru Minakawa, Shinji Kasai, Kyo Itoyama, Ken Maeda, Haruhiko Isawa

{"title":"Genetic, phylogenetic, and serological analysis of a Getah virus strain isolated from Culex tritaeniorhynchus mosquitoes in Nagasaki, Japan in 2022.","authors":"Ryo Matsumura, Hiroshi Bannai, Manabu Nemoto, Yukiko Higa, Izumi Kai, Toshinori Sasaki, Kyoko Futami, Akira Yoshikawa, Ryosuke Fujita, Masato Hino, Kosuke Nagata, Ryusei Kuwata, Yoshihiro Kaku, Daisuke Kobayashi, Noboru Minakawa, Shinji Kasai, Kyo Itoyama, Ken Maeda, Haruhiko Isawa","doi":"10.7883/yoken.JJID.2024.250","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.250","url":null,"abstract":"Getah virus (GETV), belonging to the genus Alphavirus within the family Togaviridae, is a mosquito-borne virus that causes fever, rash, and edema in horses and fatalities and pregnancy disorders in pigs. It has caused occasional outbreaks in horse populations in Japan, China, and India, and endemic areas are gradually expanding, particularly in Asia and Oceania. In this study, we isolated a new GETV strain from Culex tritaeniorhynchus mosquitoes collected from Nagasaki Prefecture, Japan in 2022. Phylogenetic analysis revealed that this new strain, 22IH8, is more closely related to previous Chinese strains than to the strains prevalent in Japan in the 2010s. Furthermore, some amino acid substitutions in the viral proteins of strain 22IH8 were found to be common with those in previous Chinese strains. These results suggest that 22IH8 strain may have recently invaded the Japanese archipelago from mainland Asia. The antiserum against the current vaccine strain, MI-110, showed high neutralization activity against the 22IH8 strain indicating the efficiency of the current vaccine for horses in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term immunity after vaccination against yellow fever in Korean travelers.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-29 DOI: 10.7883/yoken.JJID.2023.290

Jihye Um, Chad Douglas Nix, William Bill Messer, Yerun Zhu, Jun-Sun Park, Matthew Harmon Collins, BumSik Chin

{"title":"Long-term immunity after vaccination against yellow fever in Korean travelers.","authors":"Jihye Um, Chad Douglas Nix, William Bill Messer, Yerun Zhu, Jun-Sun Park, Matthew Harmon Collins, BumSik Chin","doi":"10.7883/yoken.JJID.2023.290","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2023.290","url":null,"abstract":"While a live-attenuated Yellow fever (YF) vaccine is known to elicit durable immunity, antibody titers may wane after vaccination. This study evaluated the long-term immunity after vaccination against YF among individuals who reside in Korea and received vaccination with YF virus-17D prior to international travel. Serum was collected between December 2018 and December 2019 at the National Medical Center, Republic of Korea from YF vaccine recipients who were vaccinated more than five years prior to sample collection. Long-term immunity against YF was assessed using three serological assays: IgG enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA), and focus reduction neutralization test (FRNT). Sixty seven subjects were enrolled. The overall positivity rates for FRNT50, IFA and ELISA were 97.0%, 86.6% and 26.9%, respectively, in a time-variable, cross-sectional sample of the cohort. While 93.8% (15/16) of samples collected ≥10 years post-vaccination remained positive by FRNT50, a significant inverse correlation was observed between FRNT50 titer and interval after vaccination (r=-0.385, p=0.001). Humoral immunity against YF was well preserved among the Korean individuals who were more than five years post-vaccination. IFA testing yielded results similar to FRNT50 testing, which may justify further development of the IFA to screen for waning immunity among those with previous YF vaccination.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody Responses and Infection Prevention following the Sixth Vaccination using the BA.1 bivalent COVID-19 vaccine among Healthcare workers during the XBB variant Dominance in Japan.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-29 DOI: 10.7883/yoken.JJID.2024.116

Misuzu Yahaba, Haruna Asano, Kengo Saito, Shota Murata, Kenji Kawasaki, Hitoshi Chiba, Shou Yokota, Hiroshi Yoshikawa, Yoriko Herai, Kazutaka Yamagishi, Yuki Shiko, Kazuyuki Matsushita, Hideki Hanaoka, Toshibumi Taniguchi, Koutaro Yokote, Hiroshi Nakajima, Eiji Ido, Hidetoshi Igari

{"title":"Antibody Responses and Infection Prevention following the Sixth Vaccination using the BA.1 bivalent COVID-19 vaccine among Healthcare workers during the XBB variant Dominance in Japan.","authors":"Misuzu Yahaba, Haruna Asano, Kengo Saito, Shota Murata, Kenji Kawasaki, Hitoshi Chiba, Shou Yokota, Hiroshi Yoshikawa, Yoriko Herai, Kazutaka Yamagishi, Yuki Shiko, Kazuyuki Matsushita, Hideki Hanaoka, Toshibumi Taniguchi, Koutaro Yokote, Hiroshi Nakajima, Eiji Ido, Hidetoshi Igari","doi":"10.7883/yoken.JJID.2024.116","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.116","url":null,"abstract":"The effect of antibodies elicited by bivalent mRNA vaccines (original and omicron BA.1) on preventing coronavirus disease 2019 (COVID-19) onset in the presence of the XBB variant remains unknown. A prospective cohort study conducted at Chiba University Hospital examined healthcare workers who received their sixth vaccination with the Pfizer-BioNTech COVID-19 bivalent mRNA vaccine (original and omicron BA.1). Researchers quantitatively measured serum anti-spike (S) antibody levels. Participants not infected during the 60-day observation period after vaccination had significantly higher S antibody titers than those who were newly infected (27756 U/mL, 95% CI [24988-30831 U/mL] vs. 15321 U/mL, 95% CI [10824-21688 U/mL], p<0.05). The risk of infection decreased by 84% when the S antibody titer exceeded 15500 U/ml. Neutralizing antibody titers against the XBB.1.16 and XBB.1.42 variants were higher in age- and sex-matched noninfected individuals than in newly infected individuals during the post-vaccination observation period. S antibody titers were highly correlated with neutralizing antibody titers. In conclusion, after the sixth COVID-19 vaccination with the bivalent mRNA vaccine (original and omicron BA.1), high S antibody titers correlated with disease prevention, even in the presence of XBB variants.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in patient characteristics, treatments, and mortality of COVID-19 between 2022 and 2020-2021.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-29 DOI: 10.7883/yoken.JJID.2024.272

Shotaro Aso, Sachiko Ono, Nobuaki Michihata, Kohei Uemura, Hideo Yasunaga

{"title":"Differences in patient characteristics, treatments, and mortality of COVID-19 between 2022 and 2020-2021.","authors":"Shotaro Aso, Sachiko Ono, Nobuaki Michihata, Kohei Uemura, Hideo Yasunaga","doi":"10.7883/yoken.JJID.2024.272","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.272","url":null,"abstract":"In 2021, vaccines against SARS-CoV-2 were developed, and the Omicron variant emerged. This study compared the characteristics, treatments, and mortality of patients with coronavirus disease 2019 (COVID-19) between 2022 and 2020-2021, using administrative claims data linked with vaccine records in a Japanese city. We identified patients underwent COVID-19 antigen or polymerase chain reaction tests and were diagnosed with COVID-19. Patient characteristics, treatments, and mortality were compared between 2022 and 2020-2021 among those diagnosed with COVID-19 and those who died. We identified 26,262 patients with COVID-19. The mortality in 2022 was lower than that in 2020-2021 (0.6% vs. 1.7%; P<0.01). Patients in 2022 were significantly less likely to receive oxygen therapy, high-flow nasal oxygenation, mechanical ventilation, steroid, or tocilizumab than those in 2020-2021. Among the deceased, the proportion of those aged ≥65 years was significantly higher in 2022 than in 2020-2021 (98.4% vs. 88.6%). On logistic regression, older age, male, and ≥3 comorbidities were associated with higher mortality, whereas ≥3 vaccinations were associated with lower mortality. Patients with COVID-19 in 2022 were less likely to require respiratory care or succumb to the disease. Older patients were more likely to die in 2022 than in 2020-2021.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Streptococcal Toxic Shock Syndrome Caused by a Streptococcus pyogenes emm22 Genotype with a CsrS Mutation: a Case Report. 化脓性链球菌emm22基因型伴有CsrS突变的STSS：病例报告。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-02-29 DOI: 10.7883/yoken.JJID.2023.332

Kaoru Ogawa, Jiro Kamiyama, Tadayoshi Ikebe, Shigemasa Taguchi, Kazuya Kiyota

{"title":"Streptococcal Toxic Shock Syndrome Caused by a Streptococcus pyogenes emm22 Genotype with a CsrS Mutation: a Case Report.","authors":"Kaoru Ogawa, Jiro Kamiyama, Tadayoshi Ikebe, Shigemasa Taguchi, Kazuya Kiyota","doi":"10.7883/yoken.JJID.2023.332","DOIUrl":"10.7883/yoken.JJID.2023.332","url":null,"abstract":"A previously healthy 22-year-old woman was admitted to our hospital after an out-of-hospital cardiac arrest. Spontaneous circulation was restored prior to arrival at the hospital. However, the patient's vital signs remained unstable. Vasopressors and hyperhydration therapy were administered. Computed tomography did not reveal a cause of the cardiac arrest. Antibiotics were initiated after obtaining blood culture samples. The patient was admitted to the intensive care unit (ICU). High-dose vasopressors and hyperhydration therapy were continued and fresh frozen plasma was transfused. Two hours after ICU admission, gram staining of a blood smear revealed the presence of Streptococcus, and the antibiotics were switched to penicillin G potassium and clindamycin, and immunoglobulins were administered. Extracorporeal membrane oxygenation was initiated 10 h after ICU admission owing to respiratory failure caused by fluid overload; however, the patient's condition did not improve and she died 40 h after admission. Blood culture results confirmed the presence of Streptococcus pyogenes; the T and M serotypes were unclassifiable. The emm genotype was emm22. Sequencing revealed the presence of streptococcal pyrogenic toxin genes, speA and speB, whereas speC was absent. CsrS, CsrR, and Rgg amino acid sequencing revealed the presence of a CsrS mutation.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"348-352"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the Proinflammatory Cytokine Profile during Acute SARS-CoV-2 Infection in People with Human Immunodeficiency Virus. 人类免疫缺陷病毒感染者急性 SARS-CoV-2 感染期间促炎细胞因子的特征。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-06-28 DOI: 10.7883/yoken.JJID.2024.184

Alitzel Anzurez, Lucky Runtuwene, Thi Thu Thao Dang, Kaori Nakayama-Hosoya, Michiko Koga, Yukihiro Yoshimura, Hiroaki Sasaki, Nobuyuki Miyata, Kazuhito Miyazaki, Yoshimasa Takahashi, Tadaki Suzuki, Hiroshi Yotsuyanagi, Natsuo Tachikawa, Tetsuro Matano, Ai Kawana-Tachikawa

{"title":"Characterization of the Proinflammatory Cytokine Profile during Acute SARS-CoV-2 Infection in People with Human Immunodeficiency Virus.","authors":"Alitzel Anzurez, Lucky Runtuwene, Thi Thu Thao Dang, Kaori Nakayama-Hosoya, Michiko Koga, Yukihiro Yoshimura, Hiroaki Sasaki, Nobuyuki Miyata, Kazuhito Miyazaki, Yoshimasa Takahashi, Tadaki Suzuki, Hiroshi Yotsuyanagi, Natsuo Tachikawa, Tetsuro Matano, Ai Kawana-Tachikawa","doi":"10.7883/yoken.JJID.2024.184","DOIUrl":"10.7883/yoken.JJID.2024.184","url":null,"abstract":"Persistent inflammation during chronic human immunodeficiency virus (HIV) infection may affect the immune response against severe acute respiratory syndrome-coronavirus 2 (SARS- CoV-2) infection. Plasma levels of multiple proinflammatory cytokines during acute SARS-CoV-2 infection were measured in people with HIV (PWH) with effective combination antiretroviral therapy. There were no significant differences in any of the measured cytokines between severity levels of coronavirus disease 2019 (COVID-19) in PWH, while most were significantly higher in HIV-uninfected individuals with severe COVID-19, suggesting that excess cytokines release by hyperinflammatory responses do not occur in individuals with severe COVID-19 with HIV infection. The strong associations between the cytokines observed in HIV-uninfected individuals, particularly between IFN-α/TNF-α and other cytokines, were lost in PWH. The steady-state plasma levels of IP-10, ICAM-1, and CD62E were significantly higher in PWH, indicating that they were in an enhanced inflammatory state. The absence of several inter-cytokine correlations was observed in in vitro lipopolysaccharide stimulus-driven cytokine production in PWH. These data suggest that inflammatory responses during SARS-CoV-2 infection in PWH are distinct from those in HIV-uninfected individuals, partially because of the underlying inflammatory state and/or impairment of innate immune cells.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"301-310"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time from Admission to the Onset of Methicillin-Resistant Staphylococcus aureus Bacteremia in a Single Acute Care Hospital in Japan. 日本一家急诊医院从入院到出现耐甲氧西林金黄色葡萄球菌菌血症的时间。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-07-31 DOI: 10.7883/yoken.JJID.2024.159

Nobumasa Okumura, Shinya Tsuzuki, Jiefu Yu, Sho Saito, Norio Ohmagari

{"title":"Time from Admission to the Onset of Methicillin-Resistant Staphylococcus aureus Bacteremia in a Single Acute Care Hospital in Japan.","authors":"Nobumasa Okumura, Shinya Tsuzuki, Jiefu Yu, Sho Saito, Norio Ohmagari","doi":"10.7883/yoken.JJID.2024.159","DOIUrl":"10.7883/yoken.JJID.2024.159","url":null,"abstract":"The spread of antimicrobial resistant organisms (AROs) poses a major threat to animal and human health. In Japan, the estimated disability-adjusted life years (DALYs) due to ARO infections is 137.9 per 100,000 persons, with methicillin-resistant Staphylococcus aureus (MRSA) being the main contributor. Factors that can contribute to DALYs in Japan include younger age and a higher number of deaths in patients with MRSA bacteremia. Moreover, longer hospital stays may contribute to the higher rates of MRSA bacteremia in Japan than in western countries. We reviewed the diagnostic procedure combination data collected from January 1, 2016 to December 31, 2020, in an acute care hospital in Tokyo, Japan. We found that the median time from admission to MRSA bacteremia onset was 26 days, which is longer than that observed in western countries however similar to that in South Korea. Furthermore, our cohort was older than those in the United States and South Korea, potentially contributing to the higher number of years of life lost in Japan. These results underscore the need to develop strategies to reduce hospitalization rates in Japan. Larger multicenter studies are needed to comprehensively evaluate the economic and health burdens of MRSA bacteremia in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"345-347"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Analysis of Factors Contributing to Household Transmission of COVID-19 Using Data from Active Epidemiological Investigations Performed in the Setagaya Ward of Tokyo, Japan. 利用在日本东京世田谷区开展的主动流行病学调查数据，分析导致 COVID-19 家庭传播的因素。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-06-28 DOI: 10.7883/yoken.JJID.2023.342

Mutsumi Kadowaki, Keiko Yasuoka, Chika Takahashi, Haruko Mukoyama, Yoshihisa Shirayama, Motoyuki Yuasa

{"title":"An Analysis of Factors Contributing to Household Transmission of COVID-19 Using Data from Active Epidemiological Investigations Performed in the Setagaya Ward of Tokyo, Japan.","authors":"Mutsumi Kadowaki, Keiko Yasuoka, Chika Takahashi, Haruko Mukoyama, Yoshihisa Shirayama, Motoyuki Yuasa","doi":"10.7883/yoken.JJID.2023.342","DOIUrl":"10.7883/yoken.JJID.2023.342","url":null,"abstract":"An active epidemiological investigation of COVID-19 cases in the Setagaya Ward of Tokyo revealed that household transmission was the main route of spread. This study aimed to identify factors associated with household transmission in patients diagnosed with COVID-19 and cohabitants, during the wild-type (WT) (December 2020) and Alpha-variant (AV) (May 2021) epidemics. Factors in index cases significantly associated with household transmission of both WT and AV virus, included more than 3 days from onset to diagnosis (WT: risk ratio [RR] 1.44, 95% confidence interval [CI] 1.16-1.79; AV: RR 1.66, 95% CI 1.32-2.08), and a household size of three or more (WT: RR 1.37, 95% CI 1.10-1.72; AV: RR 1.29, 95% CI 1.05-1.59). Household transmission of WT was also significantly associated with the index case being aged ≥65 years (RR 2.39, 95% CI 1.26-4.54) and symptomatic at diagnosis (RR 3.05, 95% CI 1.22-7.63). Among cohabitants, factors associated with household transmission included being the spouse/partner of the index case (WT: RR 1.68, 95% CI 1.34-2.10; AV: RR 1.97, 95% CI 1.59-2.43) and at least 3 days from onset to diagnosis of the index case (WT: RR 1.48, 95% CI 1.21-1.82; AV: RR 1.86, 95% CI 1.52-2.28). Early diagnosis and isolation are effective for preventing household transmission.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"317-324"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0