Japanese journal of infectious diseases最新文献

Microbiological characteristics and drug resistance rates of Candida auris isolates in Japan.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-31 DOI: 10.7883/yoken.JJID.2025.025

Masahiro Abe, Ami Koizumi, Takashi Umeyama, Hiroko Tomuro, Yasunori Muraosa, Nobuko Nakayama, Sayoko Oiki, Satoshi Shimada, Yuko Murakami, Masayuki Ota, Itsuro Yoshimi, Azusa Takahashi, Takashi Ono, Masaru Sasaki, Eri Uchida-Fujii, Manami Nakashita, Hitomi Kurosu, Takuya Yamagishi, Takayuki Shinohara, Yasutaka Hoshino, Yoshitsugu Miyazaki

{"title":"Microbiological characteristics and drug resistance rates of Candida auris isolates in Japan.","authors":"Masahiro Abe, Ami Koizumi, Takashi Umeyama, Hiroko Tomuro, Yasunori Muraosa, Nobuko Nakayama, Sayoko Oiki, Satoshi Shimada, Yuko Murakami, Masayuki Ota, Itsuro Yoshimi, Azusa Takahashi, Takashi Ono, Masaru Sasaki, Eri Uchida-Fujii, Manami Nakashita, Hitomi Kurosu, Takuya Yamagishi, Takayuki Shinohara, Yasutaka Hoshino, Yoshitsugu Miyazaki","doi":"10.7883/yoken.JJID.2025.025","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.025","url":null,"abstract":"Candida auris (C. auris) was initially isolated from a Japanese patient, and this species is an emerging fungus nowadays owing to its long-term colonization capabilities and high resistance to antifungal drugs. However, accurate domestic epidemiology of C. auris remains unknown. We here collected C. auris isolates reported from hospitals, public health centers, and public health institutes based on the administrative liaison. Moreover, we collected stocked C. auris isolates from three nongovernmental laboratory companies. Seventy C. auris isolates were collected during the study period. C. auris isolates predominantly originated from ear discharge clinical samples. Clade determination based on ITS-D1/D2 regions and CauMT1 locus revealed that almost all isolates belonged to clade II; however, one ear discharge-derived isolate belonged to clade I. Whole genome sequencing also confirmed this clade I C. auris isolate. Regarding drug susceptibilities, 20% of isolates were resistant to fluconazole; however, no isolates exhibited polyene or echinocandin resistance. Therefore, C. auris isolates in Japan were generally derived from ear discharges and belonged to clade II. However, ear discharge-derived isolates may not exclusively belong to clade II. Although no invasive cases were reported during the study period, continuing surveillance program for describing clear domestic epidemiology would be necessary.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevalence of eight viruses and pertussis in pregnant women at a regional hospital in Japan in 2022: Comparison with previous studies.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-31 DOI: 10.7883/yoken.JJID.2024.307

Koji Takemoto, Naoko Nishimura, Haruna Kuriyama, Yotaro Kondo, Masanori Sugiura, Mai Umehara, Takuya Akano, Mami Watarai, Kanayo Ochiai, Haruka Mimatsu, Kensei Gotoh, Takao Ozaki

{"title":"Seroprevalence of eight viruses and pertussis in pregnant women at a regional hospital in Japan in 2022: Comparison with previous studies.","authors":"Koji Takemoto, Naoko Nishimura, Haruna Kuriyama, Yotaro Kondo, Masanori Sugiura, Mai Umehara, Takuya Akano, Mami Watarai, Kanayo Ochiai, Haruka Mimatsu, Kensei Gotoh, Takao Ozaki","doi":"10.7883/yoken.JJID.2024.307","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.307","url":null,"abstract":"This study evaluated the prevalence of antibodies against eight viruses and pertussis in the serum collected from 191 pregnant women in 2022. Serum IgG antibodies against the following viruses and pertussis toxin (PT) were measured: measles virus (MV), rubella virus (RV), mumps virus (MuV), varicella-zoster virus (VZV), herpes simplex virus (HSV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human parvovirus B19 (PVB19). Infection history and immunization status were simultaneously obtained using a survey questionnaire for vaccine-preventable diseases of measles, rubella, mumps, varicella, and pertussis. Our results were compared with those of our previous studies using umbilical cord blood samples in 2001-2002 and 2013 for eight viruses and a 2016-2018 study for pertussis. Seroprevalence data in 2022 were 88.5% for MV; 86.4% for RV; 46.1% for MuV; 91.1% for VZV; 47.6% for HSV; 61.3% for CMV; 93.7% for EBV; 69.6% for PVB19 and 63.4% for PT. The seroprevalence of all diseases, except for PVB19 and pertussis, continued to decline over time. The mean IgG antibody titers were significantly lower and the vaccination coverage rates were significantly higher in four vaccine-preventable viral diseases than previous results. Thus, trends in seroprevalence status for these pathogens should be monitored in pregnant women.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The characteristics of cardiac injury in patients with severe fever with thrombocytopenia syndrome.

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-31 DOI: 10.7883/yoken.JJID.2024.254

Jing Sun, Yao Hao, Junying Niu, Zhixiang Du, Jianghua Yang

{"title":"The characteristics of cardiac injury in patients with severe fever with thrombocytopenia syndrome.","authors":"Jing Sun, Yao Hao, Junying Niu, Zhixiang Du, Jianghua Yang","doi":"10.7883/yoken.JJID.2024.254","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.254","url":null,"abstract":"This research sought to delineate the characteristics of cardiac injury in individuals diagnosed with severe fever with thrombocytopenia syndrome (SFTS) and to ascertain its relationship with prognosis. A retrospective analysis was conducted in 324 patients diagnosed with SFTS between January 2021 and December 2023, patients were categorized into survival and non-survival groups. Univariate and multivariate analyses identified significant indicators and predicted mortality risk factors. Statistically significant differences between the two groups were found in various parameters: age, history of hypertension, presence of diarrhea, petechiae, neurological abnormalities, and numerous laboratory measures. These included lymphocyte, monocyte, and platelet counts, as well as levels of liver enzymes, kidney function markers, cardiac biomarkers, clotting factors, inflammatory markers, Dabie Banda virus RNA, heart rate, PR interval, QT interval and incidence of ST depression. Age, history of hypertension, neurological abnormalities, Cr, PT and QT intervals as independent risk factors for mortality. The incidence of viral myocarditis in patients with SFTS was 64.12%, the non-survival group demonstrated a higher incidence of cardiac injury, which was both earlier and more severe. The incidence of viral myocarditis in patients with SFTS is closely related to the prognosis.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-woven Masks and SARS-CoV-2 Infection in a Cluster Setting in Japan. 日本聚集性环境中的无纺布口罩与SARS-CoV-2感染。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-21 Epub Date: 2024-11-29 DOI: 10.7883/yoken.JJID.2023.059

Yukari Takahashi, Soshi Takao, Tomoka Kadowaki, Naomi Matsumoto, Takashi Yorifuji

{"title":"Non-woven Masks and SARS-CoV-2 Infection in a Cluster Setting in Japan.","authors":"Yukari Takahashi, Soshi Takao, Tomoka Kadowaki, Naomi Matsumoto, Takashi Yorifuji","doi":"10.7883/yoken.JJID.2023.059","DOIUrl":"10.7883/yoken.JJID.2023.059","url":null,"abstract":"Evidence regarding the types of masks that are effective in preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. We identified the mask types that were effective against SARS-CoV-2 infection in a cluster setting in Japan. Data from a cluster of employees with coronavirus disease 2019 at a manufacturing company in mid-August 2021 were retrospectively reviewed. A total of 87 employees who reported the type of mask worn were included. The types of masks were dichotomized into non-woven masks or other types of masks, such as cloth or urethane masks. The association between mask type and SARS-CoV-2 infection was determined using logistic regression analysis after adjusting for potential confounders. Participants who wore non-woven masks were less likely to be infected with SARS-CoV-2 (9.7%) than those who wore other types of masks (26.7%). After adjusting for potential confounders, wearing a non-woven mask was significantly associated with a reduced risk of infection compared to wearing other types of masks (odds ratio, 0.10; 95% confidence interval, 0.01-0.80). Non-woven masks were more effective in preventing SARS-CoV-2 infection in a cluster setting than other types of masks, such as cloth or urethane masks.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"110-113"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Human Coronavirus-OC43 in Nasopharyngeal Swab Specimens Via Immunofluorescence Staining Using Human Serum and an Anti-human Antibody. 人血清和抗人抗体免疫荧光染色法检测鼻咽拭子标本中人冠状病毒oc43

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-21 Epub Date: 2024-11-29 DOI: 10.7883/yoken.JJID.2024.001

Mutsuo Yamaya, Oshi Watanabe, Yuki Kitai, Yusuke Sayama, Suguru Ohmiya, Hidekazu Nishimura

{"title":"Detection of Human Coronavirus-OC43 in Nasopharyngeal Swab Specimens Via Immunofluorescence Staining Using Human Serum and an Anti-human Antibody.","authors":"Mutsuo Yamaya, Oshi Watanabe, Yuki Kitai, Yusuke Sayama, Suguru Ohmiya, Hidekazu Nishimura","doi":"10.7883/yoken.JJID.2024.001","DOIUrl":"10.7883/yoken.JJID.2024.001","url":null,"abstract":"Immunofluorescence methods using cell lines to detect seasonal human coronavirus (HCoV)-OC43 in nasopharyngeal swab specimens have not yet been established. A human rectal adenocarcinoma cell line (HRT-18) was exposed to the specimens obtained from patients with upper respiratory tract infections. Immunofluorescence staining was conducted using a combination of human serum containing an HCoV-OC43 anti-spike protein antibody and a fluorescence-labeled anti-human antibody. Positive staining in HRT-18 cells was detected after exposure to specimens obtained from nine of eleven patients in whom HCoV-OC43 RNA was detected using the FilmArray method. Increased viral RNA levels in the supernatant were also detected in HRT-18 cells exposed to specimens obtained from four of five patients. In contrast, positive staining was not detected in HRT-18 cells exposed to six patient specimens that tested negative for RNA from 17 types and subtypes of respiratory viruses, including HCoV-OC43. Cells inoculated with the established strain HCoV-OC43 (ATCC VR-759) also showed positive staining. These findings suggest that replication-competent HCoV-OC43 in the specimens can be detected via immunofluorescence staining of HRT-18 cells with human serum. Using this method, positive staining for viruses other than HCoV-OC43 may be obtained.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"91-98"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic, Phylogenetic, and Serological Analysis of a Getah Virus Strain Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2022. 2022年日本长崎三带喙库蚊分离株Getah病毒的遗传、系统发育和血清学分析

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-21 Epub Date: 2024-11-29 DOI: 10.7883/yoken.JJID.2024.250

Ryo Matsumura, Hiroshi Bannai, Manabu Nemoto, Yukiko Higa, Izumi Kai, Toshinori Sasaki, Kyoko Futami, Akira Yoshikawa, Ryosuke Fujita, Masato Hino, Kosuke Nagata, Ryusei Kuwata, Yoshihiro Kaku, Daisuke Kobayashi, Noboru Minakawa, Shinji Kasai, Kyo Itoyama, Ken Maeda, Haruhiko Isawa

{"title":"Genetic, Phylogenetic, and Serological Analysis of a Getah Virus Strain Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2022.","authors":"Ryo Matsumura, Hiroshi Bannai, Manabu Nemoto, Yukiko Higa, Izumi Kai, Toshinori Sasaki, Kyoko Futami, Akira Yoshikawa, Ryosuke Fujita, Masato Hino, Kosuke Nagata, Ryusei Kuwata, Yoshihiro Kaku, Daisuke Kobayashi, Noboru Minakawa, Shinji Kasai, Kyo Itoyama, Ken Maeda, Haruhiko Isawa","doi":"10.7883/yoken.JJID.2024.250","DOIUrl":"10.7883/yoken.JJID.2024.250","url":null,"abstract":"Getah virus (GETV), belonging to the genus Alphavirus within the family Togaviridae, is a mosquito-borne virus that causes fever, rash, edema in horses, fatalities, and pregnancy disorders in pigs. It has caused occasional outbreaks in horse populations in Japan, China, and India, and the endemic areas are gradually expanding, particularly in Asia and Oceania. In this study, we isolated a new GETV strain from Culex tritaeniorhynchus mosquitoes collected in Nagasaki Prefecture, Japan, in 2022. Phylogenetic analysis demonstrated that this new strain, 22IH8, was more closely related to previous Chinese strains than to the strains prevalent in Japan in the 2010s. Furthermore, some amino acid substitutions in the viral proteins of strain 22IH8 were similar to those in previous Chinese strains. These results indicate that strain 22IH8 may have recently invaded the Japanese archipelago from mainland Asia. The antiserum against the current vaccine strain MI-110 demonstrated high neutralization activity against the strain 22IH8, indicating the efficiency of the current vaccine for horses in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"71-78"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Immunity after Vaccination against Yellow Fever in Korean Travelers. 韩国游客接种黄热病疫苗后长期免疫。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-21 Epub Date: 2024-11-29 DOI: 10.7883/yoken.JJID.2023.290

Jihye Um, Chad Douglas Nix, William Bill Messer, Yerun Zhu, Jun-Sun Park, Matthew Harmon Collins, BumSik Chin

{"title":"Long-Term Immunity after Vaccination against Yellow Fever in Korean Travelers.","authors":"Jihye Um, Chad Douglas Nix, William Bill Messer, Yerun Zhu, Jun-Sun Park, Matthew Harmon Collins, BumSik Chin","doi":"10.7883/yoken.JJID.2023.290","DOIUrl":"10.7883/yoken.JJID.2023.290","url":null,"abstract":"Although a live-attenuated yellow fever (YF) vaccine is known to elicit durable immunity, antibody titers may wane after vaccination. This study evaluated long-term immunity after vaccination against YF among individuals who resided in Korea and were vaccinated with YF virus- 17D prior to international travel. Serum was collected between December 2018 and December 2019 at the National Medical Center, Republic of Korea, from YF vaccine recipients who had been vaccinated for more than five years prior to sample collection. Long-term immunity against YF was assessed using three serological assays: IgG enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA), and the focus reduction neutralization test (FRNT). Sixty-seven patients were enrolled in this study. The overall positivity rates for 50% focus reduction neutralization test (FRNT50 ), IFA, and ELISA in a time-variable cross-sectional sample of the cohort were 97.0%, 86.6%, and 26.9%, respectively. While 93.8% (15/16) of samples collected ≥10 years post-vaccination remained positive by FRNT50 , a significant inverse correlation was observed between FRNT50 titer and interval after vaccination (R = - 0.385, P = 0.001). Humoral immunity against YF was well preserved among Korean individuals who were vaccinated more than five years ago. IFA testing yielded results similar to those of FRNT50 testing, which may justify the further development of IFA to screen for waning immunity among those with previous YF vaccination.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"79-84"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical Analyses of Skin Lesions with Monkeypox Virus A29 and A35 Antibodies: A Novel Insight for Clinical-Histopathological Forms. 用 MPXV A29 和 A35 抗体对猴痘皮肤病变进行免疫组化分析：临床病理形式的新见解。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-21 Epub Date: 2024-10-31 DOI: 10.7883/yoken.JJID.2024.145

Mei Shi, Chun-Yu Zhang, Dan-Yang Zou, Juan Wu, Nan-Hui Wu, Li-Yan Ni, Zhi-Fang Guan, Qian Du, Rui-Rui Peng, Fu-Quan Long

{"title":"Immunohistochemical Analyses of Skin Lesions with Monkeypox Virus A29 and A35 Antibodies: A Novel Insight for Clinical-Histopathological Forms.","authors":"Mei Shi, Chun-Yu Zhang, Dan-Yang Zou, Juan Wu, Nan-Hui Wu, Li-Yan Ni, Zhi-Fang Guan, Qian Du, Rui-Rui Peng, Fu-Quan Long","doi":"10.7883/yoken.JJID.2024.145","DOIUrl":"10.7883/yoken.JJID.2024.145","url":null,"abstract":"The aim of this study was to describe the clinical, histopathological, and immunohistochemical characteristics of monkeypox (MPX) and offer meaningful insights into the clinicopathological characteristics. Eight males who have sex with males and were diagnosed with MPX based on positive results from MPX virus (MPXV)-specific polymerase chain reaction were recruited. Skin biopsies were obtained from four selected lesions, including typical and atypical forms. Histopathological examinations of atypical solitary ulceration revealed infiltrating inflammatory cells, predominantly plasma cells and lymphocytes forming a \"sleeve\" around the superficial vessels of the dermis. These features may be misinterpreted as indicative of cutaneous syphilis. In addition, typical pustular lesions had a central necrotic epidermis accompanied by a perivascular inflammatory infiltrate dominated by neutrophils, as well as ballooning and reticular degeneration of keratinocytes. Additionally, multinucleated keratinocytes and eosinophilic cytoplasmic inclusions (Guarnieri bodies) were observed. Importantly, this study represents a pioneering report on the immunohistochemical localization of MPXV A29 and A35 proteins in skin lesions, distinguishing it from previous studies that focused on detecting vaccinia virus proteins. The anti-MPXV A29 antibody had intense cytoplasmic staining, specifically within the affected keratinocytes in the adjacent epidermis and hair follicles, thereby contributing to the diagnosis of MPX, particularly in individuals with atypical skin lesions.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"55-62"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric Cancer and Associated Pathogens: Is There Any Association in the Moroccan Region? 胃癌与相关病原体：摩洛哥地区是否存在关联？

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-21 Epub Date: 2024-10-31 DOI: 10.7883/yoken.JJID.2024.147

Samia Alaoui Boukhris, Mounia El Khadir, Safae Karim, Tiatou Souho, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Mohamed El Abkari, Bahia Bennani

{"title":"Gastric Cancer and Associated Pathogens: Is There Any Association in the Moroccan Region?","authors":"Samia Alaoui Boukhris, Mounia El Khadir, Safae Karim, Tiatou Souho, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Mohamed El Abkari, Bahia Bennani","doi":"10.7883/yoken.JJID.2024.147","DOIUrl":"10.7883/yoken.JJID.2024.147","url":null,"abstract":"Helicobacter pylori, Epstein-Barr virus (EBV), and human papillomavirus (HPV) are three pathogens associated with various human cancers. This study aimed to investigate the role of these pathogens in gastric cancer in a Moroccan population. A retrospective study was conducted with participants attending the Gastroenterology Department of Hassan II University Hospital in Fez. In total, 279 participants were enrolled in this study. Helicobacter pylori, EBV, and HPV were detected and genotyped using polymerase chain reaction. Significant associations have been established between H. pylori and EBV and gastric cancer. A total of 93.4% and 43.3% of gastric cancer cases were related to H. pylori and EBV, respectively (P ≤ 0.01). Helicobacter pylori-EBV co-infection was responsible for 31.6% of gastric cancer cases (P < 0.01). Correlation between pathogen genotypes and gastric cancer showed that 54.6% of gastric cancer EBV positive cases had a 30 bp deletion in the LMP1 gene, whereas 16% of gastric cancer cases had high-risk HPV genotypes (P = 0.21). These results highlight the possible role of co-infection in gastric cancer development.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"99-105"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody Responses and Infection Prevention Following the Sixth Vaccination Using the BA.1 Bivalent COVID-19 Vaccine Among Healthcare Workers During the XBB Variant Dominance in Japan. 日本XBB变异优势期医护人员第六次接种BA.1二价COVID-19疫苗后的抗体反应和感染预防

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-03-21 Epub Date: 2024-11-29 DOI: 10.7883/yoken.JJID.2024.116

Misuzu Yahaba, Haruna Asano, Kengo Saito, Shota Murata, Kenji Kawasaki, Hitoshi Chiba, Shou Yokota, Hiroshi Yoshikawa, Yoriko Herai, Kazutaka Yamagishi, Yuki Shiko, Kazuyuki Matsushita, Hideki Hanaoka, Toshibumi Taniguchi, Koutaro Yokote, Hiroshi Nakajima, Eiji Ido, Hidetoshi Igari

{"title":"Antibody Responses and Infection Prevention Following the Sixth Vaccination Using the BA.1 Bivalent COVID-19 Vaccine Among Healthcare Workers During the XBB Variant Dominance in Japan.","authors":"Misuzu Yahaba, Haruna Asano, Kengo Saito, Shota Murata, Kenji Kawasaki, Hitoshi Chiba, Shou Yokota, Hiroshi Yoshikawa, Yoriko Herai, Kazutaka Yamagishi, Yuki Shiko, Kazuyuki Matsushita, Hideki Hanaoka, Toshibumi Taniguchi, Koutaro Yokote, Hiroshi Nakajima, Eiji Ido, Hidetoshi Igari","doi":"10.7883/yoken.JJID.2024.116","DOIUrl":"10.7883/yoken.JJID.2024.116","url":null,"abstract":"The effect of the antibodies elicited by bivalent mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (the original strain and Omicron variant BA.1) on preventing coronavirus disease 2019 (COVID-19) onset during the XBB variant dominance remains unknown. We conducted a prospective cohort study at Chiba University Hospital and examined healthcare workers who received the Pfizer-BioNTech bivalent mRNA COVID-19 vaccine (targeting the original and Omicron BA.1) as their sixth dose of COVID-19 vaccine. The serum antibodies against SARS-CoV-2 spike (S) protein were measured quantitatively. Participants who were not infected during the 60-day observation period following the sixth vaccination had significantly higher S antibody titers than those who were newly infected (27,756 U/mL, 95% confidence interval [CI] 24,988-30,831 U/mL vs. 15,321 U/mL, 95% CI 10,824-21,688 U/mL; P < 0.05). S antibody titer ≥15,500 U/mL decreased the risk of infection by 84%. Neutralizing antibody titers against the XBB.1.16 and XBB.1.42 variants were higher in age- and sex-matched non-infected individuals than in newly infected individuals during the post-vaccination observation period. S antibody titers were highly correlated with neutralizing antibody titers. In conclusion, after the sixth vaccination with a bivalent mRNA COVID-19 vaccine, high S antibody titers correlated with disease prevention, even in the presence of the XBB variants.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"106-109"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0