The characteristics of cardiac injury in patients with severe fever with thrombocytopenia syndrome.

Abstract

This research sought to delineate the characteristics of cardiac injury in individuals diagnosed with severe fever with thrombocytopenia syndrome (SFTS) and to ascertain its relationship with prognosis. A retrospective analysis was conducted in 324 patients diagnosed with SFTS between January 2021 and December 2023, patients were categorized into survival and non-survival groups. Univariate and multivariate analyses identified significant indicators and predicted mortality risk factors. Statistically significant differences between the two groups were found in various parameters: age, history of hypertension, presence of diarrhea, petechiae, neurological abnormalities, and numerous laboratory measures. These included lymphocyte, monocyte, and platelet counts, as well as levels of liver enzymes, kidney function markers, cardiac biomarkers, clotting factors, inflammatory markers, Dabie Banda virus RNA, heart rate, PR interval, QT interval and incidence of ST depression. Age, history of hypertension, neurological abnormalities, Cr, PT and QT intervals as independent risk factors for mortality. The incidence of viral myocarditis in patients with SFTS was 64.12%, the non-survival group demonstrated a higher incidence of cardiac injury, which was both earlier and more severe. The incidence of viral myocarditis in patients with SFTS is closely related to the prognosis.