ptxP3等位基因耐大环内酯百日咳在日本冲绳的多克隆传播

IF 1.1 4区 医学 Q4 INFECTIOUS DISEASES
Tetsuya Kakita, Haruno Taira, Tsuyoshi Kudeken, Megumi Kuniyoshi, Taketoshi Takara, Morimi Teruya, Hisako Kyan, Makoto Ohnishi
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引用次数: 0

摘要

自2024年11月以来,冲绳县持续的百日咳流行已导致227例报告病例。2024年12月至2025年2月,共采集临床标本31例。我们分离到18株耐大环内酯百日咳博德泰拉(MRBP)菌株,所有菌株均携带23S rRNA基因A2047G突变,经实时PCR证实。对2024年11月分离的2个MRBP和本次调查的18个MRBP进行了基因组分析。冲绳所有MRBP均与中国(P745)和法国(FR7302)的ptxP3等位基因形成遗传相关集群。而来自冲绳的MRBP毒株被分成3个聚类,每个聚类之间至少有8个snp,且与P745和FR7302不同,提示ptxP3 MRBP在冲绳存在多源传播。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multiclonal dissemination of ptxP3 allele macrolide-resistant Bordetella pertussis in Okinawa, Japan.

An ongoing pertussis epidemic in Okinawa has resulted in 227 reported cases since November 2024. Between December 2024 and February 2025, clinical specimens were collected from 31 cases. We isolated 18 macrolide-resistant Bordetella pertussis (MRBP) strains, all harboring the A2047G mutation in the 23S rRNA gene, confirmed by real-time PCR. Genomic analysis was performed on two MRBP isolated in November 2024 and the 18 MRBP from the current survey. All MRBP in Okinawa formed genetically related clusters with the ptxP3 allele in China (P745) and France (FR7302). However, MRBP strains from Okinawa were divided into three clusters, each with at least eight SNPs between them, and distinct from P745 and FR7302, suggesting the multi-source dissemination of ptxP3 MRBP in Okinawa.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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