Japanese journal of infectious diseases最新文献_第2页

Incidence of the Extra-intestinal Pathogenic Escherichia coli (ExPEC) Infections within University Hospital Population. 大学医院人群肠道外致病性大肠杆菌（ExPEC）感染发生率

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-09-17 Epub Date: 2025-12-26 DOI: 10.7883/yoken.JJID.2025.155

Mariko Nishikitani, Shoji Tokunaga, Tasuku Okui, Yasunobu Nohara, Makiko Kiyosuke, Takanori Yamashita, Atsushi Takada, Dongchon Kang, Atsushi Momose, Yoshikazu Nakayama, Naoki Nakashima

{"title":"Incidence of the Extra-intestinal Pathogenic Escherichia coli (ExPEC) Infections within University Hospital Population.","authors":"Mariko Nishikitani, Shoji Tokunaga, Tasuku Okui, Yasunobu Nohara, Makiko Kiyosuke, Takanori Yamashita, Atsushi Takada, Dongchon Kang, Atsushi Momose, Yoshikazu Nakayama, Naoki Nakashima","doi":"10.7883/yoken.JJID.2025.155","DOIUrl":"10.7883/yoken.JJID.2025.155","url":null,"abstract":"This study estimated the incidence of extraintestinal pathogenic Escherichia coli (E. coli; ExPEC) infections at Kyushu University Hospital from 2013 to 2018, analyzing 63,041 inpatients and 178,690 outpatients aged ≥20 years. ExPEC infections were defined as E. coli detection in sterile specimens or urine specimens (≥103 CFU/mL) with increased Sequential Organ Failure Assessment (SOFA) scores or urological infection diagnosis codes. The incidence rate was substantially higher in hospitalized patients (1,209.3 per 100,000 person-years) compared to outpatients (94.5 per 100,000 person-years), with females showing slightly higher rates in both groups. Age was a significant risk factor, with incidence rates increasing markedly in patients aged ≥60 years (inpatients: 1,431.6; outpatients: 125.3 per 100,000 person-years). Importantly, the study revealed that relying solely on diagnostic names underestimated the true number of ExPEC infection cases. The precision rate, defined as the proportion of cases (n = 61) with both E. coli isolated and clinical inflammatory symptoms who received an infectious disease diagnosis (n = 46), was at most 75% for female outpatients. These findings suggest that comprehensive microbiological data combined with clinical criteria provide more accurate surveillance. These findings establish baseline incidence rates for ExPEC infections in a Japanese hospital setting and highlight the clinical significance of these infections, particularly in elderly hospitalized patients.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"173-184"},"PeriodicalIF":1.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic analysis of Streptococcus pyogenes isolated in Akita Prefecture, Japan, between 2017 and 2025, revealing the spread of M1_13SNPs possessing prophage-associated virulence genes and sic with unique mutations. 2017 - 2025年在日本秋田县分离的化脓性链球菌的遗传分析，揭示了具有噬菌体相关毒力基因的m113snp和具有独特突变的sic的传播。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2026.049

Yusei Sekiya, Takayuki Konno, Yuho Ito, Yuiko Sato, Shiho Takahashi

{"title":"Genetic analysis of Streptococcus pyogenes isolated in Akita Prefecture, Japan, between 2017 and 2025, revealing the spread of M113SNPs possessing prophage-associated virulence genes and sic with unique mutations.","authors":"Yusei Sekiya, Takayuki Konno, Yuho Ito, Yuiko Sato, Shiho Takahashi","doi":"10.7883/yoken.JJID.2026.049","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.049","url":null,"abstract":"In recent years, the number of Group A Streptococcus-associated infections has increased significantly in Akita Prefecture. An analysis of isolates collected between 2017 and 2025 revealed that the intermediate M113SNPs lineage has gained predominance as the cause, surpassing both the ancestral M1global and globally prevalent hypervirulent M1UK lineages. M113SNPs specifically harbored speC, spd1, and sdaD2; the latter was also present in most of M1UK. Furthermore, M113SNPs possessed unique mutations in sic, with the majority of the identified sic genotypes being novel variants. In the southern region of Akita, where the outbreak was particularly intense, region-specific subvariants characterized by aspartic acid substitutions were identified. These findings suggest that the surge in Group A Streptococcus-associated infections in Akita Prefecture was not merely caused by the introduction of a widespread global clone but was driven in part by the dissemination of the M113SNPs lineage, which possesses distinctive genetic features and may have undergone localized evolutionary adaptation.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Virucidal Activity of Chlorine Dioxide against Hepatitis B Virus. 二氧化氯对乙型肝炎病毒的杀病毒活性评价。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2026.047

Ming Chen, Caroline Donzeli Pereira, Koichi Watashi, Takashi Shibata, Takanori Miura

{"title":"Evaluation of the Virucidal Activity of Chlorine Dioxide against Hepatitis B Virus.","authors":"Ming Chen, Caroline Donzeli Pereira, Koichi Watashi, Takashi Shibata, Takanori Miura","doi":"10.7883/yoken.JJID.2026.047","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.047","url":null,"abstract":"Hepatitis B virus (HBV) remains a major global public health concern, with numerous nosocomial and occupational outbreaks reported. Preventing indirect HBV transmission through effective disinfection is crucial. This study evaluated the virucidal activity of chlorine dioxide (ClO₂) against HBV and compared it with sodium hypochlorite (NaClO). Pretreatment of HBV with ClO₂ at 10, 100, and 250 ppm (mg/L) for 1 min reduced hepatitis B surface antigen (HBsAg) release to 65.5%, 21.9%, and 7.0%; hepatitis B core (HBc)-positive cells to 59.1%, 27.0%, and 6.6%; intracellular HBV RNA to 71.5%, 31.6%, and 3.0%; and extracellular HBV DNA to 82.2%, 42.6%, and 14.1%, respectively. At identical concentrations, NaClO produced smaller reductions. In the presence of organic matter, no significant reduction in ClO₂ activity against HBV was observed. ClO₂ demonstrated approximately 2.2-fold greater anti-HBV potency than NaClO with and without bovine serum albumin and sheep erythrocytes. Neutralizer, cell-permissiveness, and ultrafiltration controls supported direct viral inactivation. These findings indicate that ClO₂ showed stronger in vitro anti-HBV activity than NaClO within the tested concentration range and conditions.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental infection of Oropouche virus in Japanese populations of Aedes albopictus and Culex mosquitoes. 日本白纹伊蚊和库蚊种群中Oropouche病毒感染的实验研究。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2026.111

Daisuke Kobayashi, Astri Nur Faizah, Mutsuyo Takayama-Ito, Madoka Kawahara, Chang-Kweng Lim, Hideki Ebihara, Shinji Kasai, Haruhiko Isawa

{"title":"Experimental infection of Oropouche virus in Japanese populations of Aedes albopictus and Culex mosquitoes.","authors":"Daisuke Kobayashi, Astri Nur Faizah, Mutsuyo Takayama-Ito, Madoka Kawahara, Chang-Kweng Lim, Hideki Ebihara, Shinji Kasai, Haruhiko Isawa","doi":"10.7883/yoken.JJID.2026.111","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.111","url":null,"abstract":"The recent geographical expansion of Oropouche virus (OROV) highlights the critical need to evaluate vector competence in non-endemic regions. This study aimed to evaluate the susceptibility of major Japanese mosquito populations (Culex quinquefasciatus, Cx. pipiens pallens, and Aedes albopictus) and a South African reference strain of Cx. quinquefasciatus to the OROV prototype strain (TRVL9760) by intrathoracic injection (ITI) and oral exposure (OE) experiments. Following ITI, 100% of the tested mosquitoes developed infections with high viral replication, particularly Ae. albopictus, demonstrating its robust cellular permissiveness. Conversely, OE yielded low infection rates in the thorax and abdomen (0-18.9%) and failed to cause systemic dissemination to secondary tissues (head, wings, and legs). These results demonstrate that the stringent midgut barriers that prevent OROV dissemination are maintained in both Japanese and reference mosquito strains. However, the robust viral replication observed upon bypassing these barriers reveals a significant latent susceptibility. By elucidating these dynamics, this study provides the first scientific evidence of the intrinsic susceptibility of Japanese mosquitoes to OROV. This foundational knowledge is not only critical for assessing current transmission risks but also serves as an essential baseline to determine whether contemporary epidemic lineages might overcome these physiological constraints in the future.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORRELATION BETWEEN NEUTROPHIL LYMPHOCYTE RATIO, PLATELET LYMPHOCYTE RATIO AND DENGUE FEVER IN CHILDREN-A CROSS-SECTIONAL STUDY. 中性粒细胞淋巴细胞比率、血小板淋巴细胞比率与儿童登革热的相关性横断面研究。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2024.385

Divya Lakshmi, Ramya Ramanathan, Sundari Subramanian

{"title":"CORRELATION BETWEEN NEUTROPHIL LYMPHOCYTE RATIO, PLATELET LYMPHOCYTE RATIO AND DENGUE FEVER IN CHILDREN-A CROSS-SECTIONAL STUDY.","authors":"Divya Lakshmi, Ramya Ramanathan, Sundari Subramanian","doi":"10.7883/yoken.JJID.2024.385","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.385","url":null,"abstract":"Dengue is a re-emerging tropical disease transmitted by mosquitoes. This cross-sectional study was conducted in the Department of Paediatrics of a tertiary care centre in South India over two years. Children and adolescents aged 0-15 years who presented with fever and were confirmed to have dengue by serological tests were included in this study. Blood was collected and sent for complete blood count (CBC) on day 3 of illness. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were derived. The sensitivity of NLR and PLR was 68.4% and 96.8% respectively, while the specificity of NLR and PLR were 41.7% and 66.7% respectively. Although PLR was found to have higher sensitivity and specificity, NLR was found to have an increased positive predictive value. The platelet-lymphocyte ratio demonstrates superiority by overall accuracy, specificity, and sensitivity, proving to be a more effective marker for identifying severe dengue cases. NLR and PLR demonstrated a strong positive correlation (r = 0.83, p <0.001). The clinical utility of these ratios has been extensively studied in other diseases, such as sepsis and COVID-19, especially in adults, but has been underutilized in children due to the lack of knowledge and limited research.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypochlorous acid is a faster and more effective antimicrobial agent against Legionella pneumophila than sodium hypochlorite. 次氯酸是一种比次氯酸钠对嗜肺军团菌更快更有效的抗菌剂。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2026.074

Goutham Belagula Manjunath, Sharda Prasad Awasthi, Tomoko Sato, Noritoshi Hatanaka, Shinji Yamasaki

{"title":"Hypochlorous acid is a faster and more effective antimicrobial agent against Legionella pneumophila than sodium hypochlorite.","authors":"Goutham Belagula Manjunath, Sharda Prasad Awasthi, Tomoko Sato, Noritoshi Hatanaka, Shinji Yamasaki","doi":"10.7883/yoken.JJID.2026.074","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.074","url":null,"abstract":"Legionella poses significant health risks in recreational waters and causes legionellosis. Although sodium hypochlorite (NaClO) is widely used for water disinfection, it has several disadvantages such as skin irritation, corrosion of surfaces and formation of harmful disinfection by-products. Hypochlorous acid (HClO) has emerged as an alternative disinfectant that may overcome these limitations. Here, we showed that 5.0 ppm highly purified HClO (iPOSH) reduced approximately 7.7 log CFU/mL of L. pneumophila to below the detection limit (10 CFU/mL) within 60 sec whereas 5.0 ppm NaClO required 180 sec to achieve the same level of reduction. Notably, iPOSH retained greater antibacterial activity than NaClO even in the presence of organic matters. iPOSH also exhibited comparable antibacterial efficacy across a pH range of 6.0-8.0. In Onsen water, 0.4 ppm iPOSH reduced approximately 7.7 log CFU/mL of L. pneumophila to below the detection limit within 60 min whereas 0.4 ppm NaClO achieved only less than 1 log CFU reduction after 60 min. These results demonstrate that 0.4 ppm iPOSH, the minimum chlorine concentration permitted for disinfection of public bathing facilities by the Japanese Ministry of Health, Labor and Welfare, exhibits effective antibacterial activity against L. pneumophila, and hence a promising alternative to NaClO.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A facile method for purifying viral immunogens using magnetic beads to generate neutralizing antibodies. 一种利用磁珠产生中和抗体纯化病毒免疫原的简便方法。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2026.016

Shota Kitayama, Atsushi Kaida, Kazuyoshi Ikuta, Hideo Shinagawa, Takehiko Ueyama

{"title":"A facile method for purifying viral immunogens using magnetic beads to generate neutralizing antibodies.","authors":"Shota Kitayama, Atsushi Kaida, Kazuyoshi Ikuta, Hideo Shinagawa, Takehiko Ueyama","doi":"10.7883/yoken.JJID.2026.016","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.016","url":null,"abstract":"Human parainfluenza virus type 3 (HPIV-3), an increasingly significant respiratory pathogen affecting both pediatric and elderly populations, currently lacks effective prophylactic or therapeutic interventions. The development of antibody-based therapeutics with the potential to prevent or treat HPIV-3 infection remains an active area of investigation. However, a major limitation of such antibody therapies is the emergence of escape mutant strains. Combination therapy employing multiple neutralizing antibodies targeting distinct epitopes has been explored as a strategy to circumvent viral escape in influenza and human immunodeficiency virus infections. However, the probability of obtaining multiple neutralizing antibodies, including those against HPIV-3, is generally low. Here, to maximize the presentation of viral surface epitopes to immune cells, we purified HPIV-3 virus using magnetic bead-based technology. The resulting antigen-magnetic bead complexes were immobilized and used to immunize mice. This strategy employs viable and infectious virion as immunogens, thereby enabling immune cells to recognize the native antigenic architecture of the viral surface with high fidelity. This method, which permits immunization while preserving the viral surface structure to the greatest extent and may be broadly applicable to many viruses, provide a simple and rapid approach for developing therapeutic antibodies during public health emergencies.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of Human Parechovirus Type 5 Meningitis in Japan, 2025. 2025年日本出现人类5型Parechovirus脑膜炎。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2025.285

Yushi Yamamoto, Aya Iwata, Kousaku Matsubara, Keigo Hamahata, Junji Eguchi, Ai Mori, Ryohei Nomoto

{"title":"Emergence of Human Parechovirus Type 5 Meningitis in Japan, 2025.","authors":"Yushi Yamamoto, Aya Iwata, Kousaku Matsubara, Keigo Hamahata, Junji Eguchi, Ai Mori, Ryohei Nomoto","doi":"10.7883/yoken.JJID.2025.285","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.285","url":null,"abstract":"Human parechovirus type 5 (HPeV-5) is rarely reported, and, thus, its clinical and virological features remain unclear. This study describes the first cluster of HPeV-5 meningitis in Japan and characterizes its clinical, laboratory, and molecular features. Six infants aged 13-42 days were identified at three municipal hospitals in Kobe, Japan, during a six-week period in summer 2025. Symptoms included fever (6/6), mottled skin (4/6), poor feeding (3/6), and rash (2/6). None developed thrombocytopenia, liver dysfunction, or cerebrospinal fluid (CSF) pleocytosis; one had leukopenia. Two infants who were tested had hyperferritinemia that persisted after defervescence. Fever resolved within three days in all infants, and all were discharged without sequelae. A polymerase chain reaction detected HPeV-5 in the CSF of all infants. A phylogenetic analysis demonstrated high VP1 nucleotide identity (>97%) with strains in Sapporo, Japan (2018), Australia (2019), and USA (2024), suggesting the circulation of a nearly identical lineage across multiple regions. HPeV-5 was also detected in 14 additional non-meningitis cases during the same period, indicating concurrent circulation in the community. These results indicate that HPeV-5 causes meningitis in young infants, even without CSF pleocytosis, and was associated with favorable outcomes in this case series. Continued molecular epidemiological surveillance is warranted.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Year-Round Dengue Surveillance in Tangerang Regency, Indonesia (2024): Clinical and Virological Features with Biomarker Evaluation. 印度尼西亚Tangerang县全年登革热监测（2024）：临床和病毒学特征与生物标志物评估。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2025.232

Dewi Lokida, Herman Kosasih, Susilowati Susilowati, Nathania Nadia Budiman, Salmawati Salmawati, Adhella Menur Naysilla, Ivana Yulian Hendarsin, Cintya Naya Danastri, Atindriya Tri Iswari, Sylvia Victoria, Achmad Muchlis

{"title":"Year-Round Dengue Surveillance in Tangerang Regency, Indonesia (2024): Clinical and Virological Features with Biomarker Evaluation.","authors":"Dewi Lokida, Herman Kosasih, Susilowati Susilowati, Nathania Nadia Budiman, Salmawati Salmawati, Adhella Menur Naysilla, Ivana Yulian Hendarsin, Cintya Naya Danastri, Atindriya Tri Iswari, Sylvia Victoria, Achmad Muchlis","doi":"10.7883/yoken.JJID.2025.232","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.232","url":null,"abstract":"Dengue remains a major public health concern in Indonesia. This study aimed to describe the epidemiology, clinical characteristics, immune responses, and genotype characterization of dengue virus (DENV) infections in Tangerang Regency, Indonesia. A year-round prospective surveillance was conducted from January 2024-January 2025 at a district hospital and two primary health centers. Febrile patients aged ≥4 years were tested using dengue NS1, IgM/IgG rapid tests, ELISA, and RT-PCR, and serum biomarkers (angiopoietin-2, IL-6, ferritin, sCD163) were quantified. Of 404 participants, 240 (59.4%) had confirmed dengue. Among RT-PCR-serotyped cases (n=192), the distribution was DENV-2 63/192 (32.8%), DENV-1 60/192 (31.3%), DENV-3 47/192 (24.5%), and DENV-4 22/192 (11.5%). Among hospitalized dengue cases (n=144), secondary infection (131/144, 91.0%) was associated with severe disease (adjusted OR=10.25; 95% CI: 1.71-197.90, p=0.034). Biomarker levels were elevated in dengue cases but did not discriminate severity, indicating the need for validation in larger cohorts using standardized definitions. Sequencing identified DENV-1 genotypes I and IV, DENV-2 Cosmopolitan, DENV-3 genotype I, and DENV-4 genotype IIa; one DENV-4 isolate carried an EDIII E384 D→H substitution warranting further investigation. Continued genomic surveillance and vaccine development that induces balanced, serotype-specific immunity are needed to support national and global dengue control.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenicity and Safety of the 9-valent Human Papillomavirus (HPV) Vaccine Administered as 2-Dose or 3-Dose Regimens in Japanese Boys and Girls Aged 9-15 Years. 9价人乳头瘤病毒（HPV）疫苗在日本9-15岁男孩和女孩中以2剂或3剂方式接种的免疫原性和安全性

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-08-31 DOI: 10.7883/yoken.JJID.2026.076

Yuzuru Takeuchi, Motoharu Yonekawa, Shinya Murata, Mariko Nakagomi, Yukako Fukao, Nobuyuki Oshima, Miyuki Sawata

{"title":"Immunogenicity and Safety of the 9-valent Human Papillomavirus (HPV) Vaccine Administered as 2-Dose or 3-Dose Regimens in Japanese Boys and Girls Aged 9-15 Years.","authors":"Yuzuru Takeuchi, Motoharu Yonekawa, Shinya Murata, Mariko Nakagomi, Yukako Fukao, Nobuyuki Oshima, Miyuki Sawata","doi":"10.7883/yoken.JJID.2026.076","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.076","url":null,"abstract":"A phase III open-label study evaluated the immunogenicity and safety of the 9-valent human papillomavirus (9vHPV) vaccine in Japanese boys and girls. Japanese boys aged 9-15 years (n = 105) received a 3-dose (Day 1, Month 2, and Month 6) regimen; Japanese boys (n = 104) and girls aged 9-14 years (n = 105) received a 2-dose (Day 1 and Month 6) regimen. Antibody responses to HPV6/11/16/18/31/33/45/52/58 were assessed at Month 7, 18, and 30 using a competitive Luminex immunoassay. Injection-site adverse events (AEs; Days 1 to 5 post-dose), systemic AEs (Days 1 to 15 post-dose), and serious AEs (duration of study) were assessed. At Month 7, for HPV types targeted by the 9vHPV vaccine, seroconversion rates were 100% in all three arms, and in cross-study comparisons with efficacy studies, anti-HPV geometric mean titers in boys were noninferior to those in Japanese men aged 16-26 years, and in girls were noninferior to those in Japanese women aged 16-26 years. Most injection-site AEs were mild to moderate in intensity. No deaths or vaccine-related serious AEs were observed. These results support immunobridging of efficacy findings in Japanese men and women to Japanese boys and girls. The 9vHPV vaccine was generally well tolerated.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0