Japanese journal of infectious diseases最新文献_第2页

Novel image-based titration method for potency testing of diphtheria toxoid in Vero cell assay. 基于图像的白喉类毒素Vero细胞效价检测新方法。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-08-29 DOI: 10.7883/yoken.JJID.2025.030

Miyuki Kimura, Masaaki Iwaki, Tsuyoshi Kenri, Mitsutoshi Senoh

引用次数: 0

Retrospective Analysis of Staphylococcus argenteus Isolated from Food-Related Specimens in Nagoya. 名古屋市食品相关标本中分离的银葡萄球菌回顾性分析。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-08-29 DOI: 10.7883/yoken.JJID.2025.130

Takashi Ichikawa, Yohei Kobayashi, Katsuaki Masuno, Shinichiro Shibata

{"title":"Retrospective Analysis of Staphylococcus argenteus Isolated from Food-Related Specimens in Nagoya.","authors":"Takashi Ichikawa, Yohei Kobayashi, Katsuaki Masuno, Shinichiro Shibata","doi":"10.7883/yoken.JJID.2025.130","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.130","url":null,"abstract":"Staphylococcus argenteus, a novel species formally named in 2015 and distinct from S. aureus, has a historical distribution that remains unclear. In this study, a total of 1,021 staphylococcal isolates collected from food-related specimens in Nagoya City between 1986 and 2022 were re-examined. Of these, 65 isolates (6.4%) were reidentified as S. argenteus. The earliest detection was in 1986, and the species has been identified in nearly every subsequent year. These findings suggest that S. argenteus had already disseminated into food-related environments by the 1980s. Furthermore, the results indicate that most S. argenteus isolates have been correctly identified in recent years, due to improvements in current MALDI-TOF MS identification. Multilocus sequence typing (MLST) revealed ST2854 as the most prevalent sequence type (ST) in this study, while clinically important strains such as ST1223 and ST2250 have been detected since the 1990s. The presence of novel and multiple STs with distinct POT types indicating that genetically diverse S. argenteus strains have been present in food-related environments since the 1980s. These results provide important insight into the historical background of S. argenteus and underscore the need for continued monitoring, particularly in food-related environments.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevalence of Hepatitis A and E virus Antibodies in Dhanusha, Madhesh Province, Nepal. 尼泊尔达努沙马德什省甲型肝炎病毒和戊型肝炎病毒抗体的血清流行率

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-08-21 Epub Date: 2025-01-31 DOI: 10.7883/yoken.JJID.2024.321

Sandesh Rimal, Sabin Shrestha, Aashma Khadka, Mami Matsuda, Ryosuke Suzuki, Shyam Prakash Dumre, Basu Dev Pandey

引用次数: 0

Detection of Host Vertebrate DNA in Tick Species Collected from Vegetation in Fukuoka, Japan. 日本福冈地区植被蜱类宿主脊椎动物DNA检测。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-08-21 Epub Date: 2024-12-27 DOI: 10.7883/yoken.JJID.2024.170

Takayuki Kobayashi, Yuki Ashizuka

引用次数: 0

The Tokyo Metropolitan Government External Quality Assessment of SARS-CoV-2 Nucleic Acid Amplification Tests for Clinics in 2023. 东京都政府2023年门诊SARS-CoV-2核酸扩增检测外部质量评价

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-08-21 Epub Date: 2025-01-31 DOI: 10.7883/yoken.JJID.2024.205

Rie Moriuchi, Ryouta Inaba, Miyuki Nagano, Mayuko Oda, Takayuki Shinkai, Toshihisa Noguchi, Yoshiyuki Sugishita, Itaru Nishizuka, Yoshikazu Ishii

{"title":"The Tokyo Metropolitan Government External Quality Assessment of SARS-CoV-2 Nucleic Acid Amplification Tests for Clinics in 2023.","authors":"Rie Moriuchi, Ryouta Inaba, Miyuki Nagano, Mayuko Oda, Takayuki Shinkai, Toshihisa Noguchi, Yoshiyuki Sugishita, Itaru Nishizuka, Yoshikazu Ishii","doi":"10.7883/yoken.JJID.2024.205","DOIUrl":"10.7883/yoken.JJID.2024.205","url":null,"abstract":"In 2023, an external quality assessment (EQA) of nucleic acid amplification tests for SARS-CoV-2 was conducted among clinics that implemented testing instruments through the Tokyo Subsidy Program for Facilities and Equipment for Testing in COVID-19. The survey samples consisted of sample 1 (20,000 copies/mL), sample 2 (10,000 copies/mL), and a negative sample. Results were obtained through cycle threshold (Ct) values and positive-negative result determinations. On-site technical support was provided to clinics that responded incorrectly. A total of 544 clinics (589 instruments) participated, and Abbott's ID NOW TM (82.2%) was the most widely used instrument. The qualitative test results showed high accuracy rates of 95.2% for Sample 1, 93.2% for Sample 2, and 96.3% for negative samples. Differences in Ct values were observed between reagents and instruments. Technical support was provided to 63 clinics. The discrepancies in the qualitative tests were mainly due to deviations from the protocol instructions, mixing of all three survey samples into one vial, and errors caused by foaming. This survey was unique in that the participants were mostly end users who were not laboratory testing specialists and mainly used point-of-care testing instruments. It is important to continue EQA to improve and maintain testing accuracy.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"125-134"},"PeriodicalIF":1.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Recombinant Type of Human Adenovirus C Composed of Types 89 and 5 in Aichi Prefecture, Japan (2016-2019). 2016-2019年日本爱知县89型和5型重组人腺病毒C型检测

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-08-21 Epub Date: 2025-01-31 DOI: 10.7883/yoken.JJID.2024.246

Emi Hirose, Hiroko Minagawa, Hirokazu Adachi, Masakazu Suzuki, Noriko Nakamura, Noriko Saito, Miyabi Ito, Chikako Mitsuoka, Katsuhiko Sato, Yoshihiro Yasui

{"title":"Detection of Recombinant Type of Human Adenovirus C Composed of Types 89 and 5 in Aichi Prefecture, Japan (2016-2019).","authors":"Emi Hirose, Hiroko Minagawa, Hirokazu Adachi, Masakazu Suzuki, Noriko Nakamura, Noriko Saito, Miyabi Ito, Chikako Mitsuoka, Katsuhiko Sato, Yoshihiro Yasui","doi":"10.7883/yoken.JJID.2024.246","DOIUrl":"10.7883/yoken.JJID.2024.246","url":null,"abstract":"Recombinant human adenoviruses (HAdVs) have been identified in many countries, including Japan. Herein, we report a recombinant HAdV-C type detected in feces with gastroenteritis infection or throat swabs with upper respiratory tract inflammation in six children in Aichi Prefecture. This type may have been prevalent in the area. Between April 2014 and March 2019, we attempted to detect HAdVs in 9,483 specimens (feces, urine, and throat and conjunctival swabs) collected from patients with suspected viral infection. A total of 220 HAdV-C isolates were obtained and serotyped using a neutralization test (NT). Of these, 62 HAdV-C strains (HAdV-C1: 15, -C2: 19, -C5: 22, and -C6: 6) were genotyped by sequencing for the three regions, penton base, hexon, and fiber regions, respectively. All 62 strains were grouped into the same genotype as the serotype for the hexon and fiber regions. In contrast, phylogenetic analysis showed that 6 of the 22 strains with serotype HAdV-C5 were grouped into HAdV-C89 for the penton base region. This type was detected as a recombinant HAdV causing severe acute respiratory infection in China between 2017 and 2021 and has been persistently detected in the transnational Aichi Prefecture over the same period.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"139-142"},"PeriodicalIF":1.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Management of Refractory Vaginal Trichomoniasis Following Initial Metronidazole Treatment Failure: a Case Series. 甲硝唑治疗失败后难治性阴道滴虫病的长期治疗：一个病例系列。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-08-21 Epub Date: 2024-12-27 DOI: 10.7883/yoken.JJID.2024.255

Taketomo Maruki, Masahiro Ishikane, Masami Kurokawa, Taketo Kubo, Yusuke Miyazato, Norio Ohmagari

{"title":"Long-Term Management of Refractory Vaginal Trichomoniasis Following Initial Metronidazole Treatment Failure: a Case Series.","authors":"Taketomo Maruki, Masahiro Ishikane, Masami Kurokawa, Taketo Kubo, Yusuke Miyazato, Norio Ohmagari","doi":"10.7883/yoken.JJID.2024.255","DOIUrl":"10.7883/yoken.JJID.2024.255","url":null,"abstract":"Guidelines for sexually transmitted infections recommend oral metronidazole (MNZ) as the first-line treatment option for vaginal trichomoniasis; however, cases of prolonged symptoms or post-treatment recurrence have been reported. This retrospective cohort study aimed to determine appropriate treatment strategies for refractory vaginal trichomoniasis. We reviewed the medical records of patients who tested positive for Trichomonas vaginalis (T. vaginalis) at the National Center for Global Health and Medicine between August 2011 and May 2023. Refractory vaginal trichomoniasis was defined as initial MNZ treatment failure. During the study period, nine cases of vaginal trichomoniasis were identified, six of which were refractory to treatment for T. vaginalis. Four patients were cured with a combination of oral and vaginal tinidazole (TNZ) therapy, one with oral TNZ, and one with two doses of MNZ. Possible causes of treatment failure include MNZ-resistant T. vaginalis, reinfection between partners, and infections of other sexually transmitted diseases. However, TNZ was effective, which suggests that MNZ-resistant T. vaginalis may have been the cause. MNZ resistance testing was not performed in this study; however, treatment with TNZ should be considered in cases of refractory vaginal trichomoniasis, possibly resulting from MNZ-resistant T. vaginalis.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"135-138"},"PeriodicalIF":1.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ensitrelvir for the treatment of COVID-19: A systematic review of evidence. 恩司替韦治疗COVID-19：证据的系统回顾

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-07-31 DOI: 10.7883/yoken.JJID.2024.372

Saeed Khorramnia, Seyed Hamid Pakzad Moghadam, Ali Sarkoohi, Mojgan Mohajeri Iravani, Amirhossein Orandi, Samrand Fattah Ghazi, Shahla Noori Ardabili, Ebadallah Shiri Malekabad, Zia Navidi

{"title":"Ensitrelvir for the treatment of COVID-19: A systematic review of evidence.","authors":"Saeed Khorramnia, Seyed Hamid Pakzad Moghadam, Ali Sarkoohi, Mojgan Mohajeri Iravani, Amirhossein Orandi, Samrand Fattah Ghazi, Shahla Noori Ardabili, Ebadallah Shiri Malekabad, Zia Navidi","doi":"10.7883/yoken.JJID.2024.372","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.372","url":null,"abstract":"Ensitrelvir is a novel antiviral drug that has been evaluated for its effectiveness against Coronavirus disease 2019 (COVID-19). This study aims to gather relevant evidence regarding the efficacy and safety of ensitrelvir in patients diagnosed with COVID-19. A systematic search was conducted in databases including PubMed, the Cochrane Library, Web of Science, and Scopus to identify pertinent studies on ensitrelvir's role in COVID-19 treatment up to September 2024. Nine studies were included in the analysis, comprising two retrospective studies, two phase 1 trials, three phase 2/3 trials, and two phase 3 trials. The findings indicated that ensitrelvir is associated with a reduced risk of death and shorter hospital stays for COVID-19 patients compared to control groups. Additionally, ensitrelvir demonstrated the ability to lower SARS-CoV-2 viral titers and RNA levels while accelerating the time to viral clearance compared to placebo. Reported adverse events were predominantly mild, with no serious adverse events noted. Ensitrelvir exhibited consistent pharmacokinetics across different populations, eliminating the need for dose adjustments. Ensitrelvir appears to be an effective and safe option for managing mild to moderate COVID-19 infections. However, further studies are needed to establish its efficacy and safety in treating COVID-19.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and genetic characteristics of human astroviruses detected during acute gastroenteritis outbreaks in Yokohama, Japan, between 2017 and 2023. 2017年至2023年日本横滨急性肠胃炎暴发期间检测到的人类星状病毒的流行病学和遗传特征

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-07-31 DOI: 10.7883/yoken.JJID.2024.411

Makoto Kumazaki, Shuzo Usuku

{"title":"Epidemiological and genetic characteristics of human astroviruses detected during acute gastroenteritis outbreaks in Yokohama, Japan, between 2017 and 2023.","authors":"Makoto Kumazaki, Shuzo Usuku","doi":"10.7883/yoken.JJID.2024.411","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.411","url":null,"abstract":"This study aimed to investigate the epidemiological and genetic characteristics of human astroviruses (HAstVs) detected during acute gastroenteritis (AG) outbreaks in Yokohama, Japan. We collected stool samples and epidemiological information between September 2017 and August 2023 and used real-time reverse transcription (RT)-PCR and/or RT-PCR to detect HAstV from 53 samples from 20 (3.1%) of the 648 virus-associated AG outbreaks during the study period. Of the 20 outbreaks investigated via sequencing, 13 were caused by classic HAstV, three by HAstV-MLB, and four were due to multiple genotypes, classic HAstV and HAstV-MLB. The strains detected in Yokohama were found to be closely related within their respective genotypes. The distribution of HAstV genotypes differed by age groups, with HAstV1 and HAstV-MLB1 primarily found in 0-3 year-olds, whereas HAstV4 typically occurred in individuals over 4 years of age. Of the 53 HAstV-infected patients, 49 (92.5%) experienced diarrhea, with 36 exhibiting only this symptom. Vomiting (18.9%) was less prevalent than diarrhea. There were no differences in the symptoms between individuals with classic HAstV and HAstV-MLB.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phylogenetic analysis of the VP1 coding region of CVA6 detected in hand-foot-and-mouth disease during surveillance from 2019 to 2024 in Japan. 2019 - 2024年日本手足口病监测检测到的CVA6病毒VP1编码区系统发育分析

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2025-07-31 DOI: 10.7883/yoken.JJID.2025.039

Hiroyuki Tsukagoshi, Mami Nagashima, Kumiko Takahashi, Katsumi Mizuta, Tatsuya Ikeda, Ryo Shimada, Akira Kawase, Hiroto Shinomiya, Reiko Okamoto-Nakagawa, Komei Shirabe, Yasuo Kaburagi, Hiroyuki Ichikawa, Monami Taguchi, Sakurako Abe, Nobuhiro Saruki

{"title":"Phylogenetic analysis of the VP1 coding region of CVA6 detected in hand-foot-and-mouth disease during surveillance from 2019 to 2024 in Japan.","authors":"Hiroyuki Tsukagoshi, Mami Nagashima, Kumiko Takahashi, Katsumi Mizuta, Tatsuya Ikeda, Ryo Shimada, Akira Kawase, Hiroto Shinomiya, Reiko Okamoto-Nakagawa, Komei Shirabe, Yasuo Kaburagi, Hiroyuki Ichikawa, Monami Taguchi, Sakurako Abe, Nobuhiro Saruki","doi":"10.7883/yoken.JJID.2025.039","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.039","url":null,"abstract":"Hand, foot, and mouth disease (HFMD) caused by enteroviruses is common in children. Recently, coxsackievirus A6 (CVA6) has been identified as a major causative agent. In this study, we conducted a phylogenetic analysis of a part of the VP1 coding region of 194 CVA6 strains detected directly from 767 nasopharyngeal swab or stool samples of HFMD patients in Japan from 2019 to 2024. The detected CVA6 strains were classified into genotype D. Moreover, the strains detected from before 2019 to 2023 belonged to cluster (cluster 1 and 2), whereas the most of strains detected in 2024 belonged to another cluster (cluster 3). Genetic identity among all detected CVA6 strains was 89.1%-100%, and genetic identity within the cluster for each detected strain was 90.6%-100% for the before 2019 (cluster 1) strains, 92.6%-100% for the 2019-2023 (cluster 2) and 94.5%-100% for the 2024 (cluster 3) strains. Most of the strains detected in 2024 were similar to the strains detected in China in 2023, suggesting that the influx of new strains caused the 2024 outbreak in Japan. HFMD is one of the most prevalent diseases in the world and its pathogenicity and antigenicity may be altered. Surveillance of the influx of new strains from outside Japan will become increasingly important.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0