{"title":"Respiratory Syncytial Virus Infection Notification Trends and Interpretation of the Reported Case Data, 2018-2021, Japan.","authors":"Miyako Otsuka, Ayu Kasamatsu, Yuzo Arima, Takuri Takahashi, Takeshi Arashiro, Katsuhiro Komase, Reiko Shimbashi, Yuuki Tsuchihashi, Yusuke Kobayashi, Osamu Takahara, Kazuhiko Kanou, Motoi Suzuki","doi":"10.7883/yoken.JJID.2024.187","DOIUrl":"10.7883/yoken.JJID.2024.187","url":null,"abstract":"<p><p>In Japan, as elsewhere, the coronavirus disease 2019 (COVID-19) pandemic has affected notification trends of respiratory syncytial virus (RSV) infection. Here, we describe the epidemiological trends of cases of RSV infection among children reported during 2018-2021 in Japan based on the national surveillance system. Compared with 2018 and 2019, 2020 saw an unprecedented decrease in notifications of RSV infection per sentinel site. However, 2021 experienced an unseasonably early and high peak at week 28 (peak week in 2018 and 2019 was week 37), with a large resurgence in notifications nationwide and across regions. Regarding age, compared with 2018 and 2019, the number and proportion of case-patients aged 2, 3, and ≥4-years increased substantially in 2021, but the number of case-patients aged <1 year decreased slightly. Furthermore, in 2021, the ratio of notifications per site from outpatient clinics to notifications per site from hospitals increased, suggesting a proportionate increase in diagnoses of clinically milder cases. Notably, RSV-attributed deaths from vital statistics also dropped substantially in 2020 and rebounded in 2021 but were fewer than in 2018 or 2019. While the incidence of RSV infections likely declined in 2020 (possibly owing to COVID-19 countermeasures) and increased in 2021, notifications in 2021 appeared to be associated with milder presentations. Given the unpredictable epidemiology of RSV, continuous monitoring and pluralistic assessments are imperative.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"51-54"},"PeriodicalIF":1.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Zhang, Lingtong Huang, Zheyue Shu, Wei Wu, Hongliu Cai, Yu Shi
{"title":"Prediction of Prognosis in Patients with Severe Fever with Thrombocytopenia Syndrome.","authors":"Yi Zhang, Lingtong Huang, Zheyue Shu, Wei Wu, Hongliu Cai, Yu Shi","doi":"10.7883/yoken.JJID.2024.015","DOIUrl":"10.7883/yoken.JJID.2024.015","url":null,"abstract":"<p><p>This study aimed to understand the clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) and identify the risk factors for prognosis. In this retrospective study, we collected epidemiological, demographic, clinical, and laboratory data from 101 patients with SFTS. Patients were divided into survival and deceased groups, and a logistic regression model was used to evaluate the association between the predictors and prognostic variables. A joint detection factor model was constructed, and a receiver operating characteristic curve was drawn. A nomogram was established using the R language, and its efficiency in diagnosing SFTS was evaluated using a calibration curve. Patients in the deceased group were more likely to be older, have a shorter hospitalization stay, and have renal and multiple organ failure than those in the survival group. Statistically significant differences were observed in the neutrophil percentage, lymphocyte percentage, neutrophil-to-lymphocyte ratio, platelet (PLT) count, aspartate aminotransferase (AST)/alanine transaminase (ALT) ratio, AST, blood urea nitrogen, lactate dehydrogenase, hydroxybutyrate dehydrogenase, thromboplastin time, and activated partial thromboplastin time between the two groups. Lymphocyte percentage, PLT count, and the AST/ALT ratio were independent risk factors for mortality in patients with SFTS. Thus, we established a prediction model for SFTS mortality with good efficiency.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"28-34"},"PeriodicalIF":1.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fatal Septic Shock Due to Dolosigranulum pigrum Bacteremia: a Case Report.","authors":"Sachiko Hakoda, Akira Ishiwata, Ryo Shimada, Shuji Hatakeyama, Makoto Kondo","doi":"10.7883/yoken.JJID.2024.178","DOIUrl":"10.7883/yoken.JJID.2024.178","url":null,"abstract":"<p><p>We report the case of a 77-year-old Japanese woman with neuromyelitis optica spectrum disorder treated with 15 mg of prednisolone daily who presented with acute septic shock and altered consciousness due to Dolosigranulum pigrum bacteremia. Intravenous fluid and broad-spectrum antibiotics were initiated; however, the patient died shortly after admission. We performed 16S rRNA sequencing and analyzed the murJ gene. A phylogenetic tree constructed using the neighbor-joining method showed that the strain belonged to Clade C3, according to the Flores Ramos classification system. Although D. pigrum is a commensal of the upper respiratory tract and is rarely associated with infections, it can occasionally cause serious infections. Further clinical and bacteriological data are needed to provide an understanding of the pathogenicity and infections caused by this organism.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"43-46"},"PeriodicalIF":1.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of viral load in the nasopharyngeal swabs of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different epidemic seasons in Gunma prefecture, Japan.","authors":"Yuki Nakazawa, Hiroyuki Tsukagoshi, Ryo Shimada, Rina Kubota, Nobuhiro Saruki","doi":"10.7883/yoken.JJID.2024.301","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.301","url":null,"abstract":"<p><p>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly undergone mutations since its emergence, based on which it has been assumed that there was a change in its characteristic, including virulence or antigenicity. In this study, we investigated the viral load in the nasopharyngeal samples of patients with SARS-CoV-2 in Gunma prefecture, Japan, from April 2, 2020, to April 1, 2023. The amount of virus in samples in the Omicron-variant-prevalent period was higher than that of strains detected in samples before week 50 of 2020, the B.1.1.284-prevalent period, the Alpha-variant-prevalent period, and the Delta-variant- prevalent period. Moreover, among Omicron variants, the sublineage BA.5-prevalent period showed higher amount of virus in the samples than BA.1-prevalent period and BA.2-prevalent period. Hence, the new variant may have been able to release more viruses into the nasopharyngeal samples during the process of repeated mutations, resulting in widespread infection. The amount of virus detected in the nasopharyngeal samples showed an increasing tendency with the evolution of the virus. Therefore, considering that the amount of virus in specimens is also vital factor contributing to the spread of infection, it is important to examine this factor in samples.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of host vertebrate DNA in tick species collected from vegetation in Fukuoka, Japan.","authors":"Takayuki Kobayashi, Yuki Ashizuka","doi":"10.7883/yoken.JJID.2024.170","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.170","url":null,"abstract":"<p><p>Ticks are vectors of tick-borne diseases (TBDs) between humans and wild vertebrates. The relationship between ticks, host vertebrates, and their pathogens should be investigated for the effective control of TBDs. Hence, this study aimed to detect vertebrate DNA in ticks by using molecular methods and identify the species of such ticks collected in Fukuoka Prefecture, which is located in the northern Kyushu area of Japan. Ticks from vegetation were collected by flagging from 2017 to 2023. Out of 152 ticks collected by flagging, 65 (42.8%) were found to have vertebrate DNA. By stage, vertebrate DNAs were detected in 26 of 83 nymphs (31.3%) and 39 of 69 adults (56.5%). Among the host vertebrates, Sika deer was the main blood-feeding source of ticks in Fukuoka Prefecture. Owing to the widespread of deer across this prefecture, control of its population and other wildlife populations could be a countermeasure of reducing TBD risk.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular detection of Mycobacterium leprae using RLEP-LAMP and restriction enzyme to ensure amplification specificity.","authors":"Mukul Sharma, Purna Dwivedi, Srishti Tripathi, Purushottam Patel, Pushpendra Singh","doi":"10.7883/yoken.JJID.2024.251","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.251","url":null,"abstract":"<p><p>Early and accurate diagnosis of leprosy is important but remains a significant challenge till date. Loop-mediated isothermal amplification (LAMP) is an isothermal process for amplification of nucleic acids at constant temperature and has been used to develop field-friendly tests for many diseases. In the present study, we have described the development of a colorimetric LAMP assay targeting Mycobacterium leprae-specific 450 bp conserved region of the repeat sequences known as RLEP. Furthermore, the amplicons of LAMP were subjected to restriction analysis by the enzyme EcoRV for specificity. This method has the potential to become an accurate and efficient alternative to Sanger sequencing which is currently in use to validate the RLEP amplified products.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term management of refractory vaginal trichomoniasis following initial metronidazole treatment failure: A case series.","authors":"Taketomo Maruki, Masahiro Ishikane, Masami Kurokawa, Taketo Kubo, Yusuke Miyazato, Norio Ohmagari","doi":"10.7883/yoken.JJID.2024.255","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.255","url":null,"abstract":"<p><p>Guidelines for sexually transmitted infections recommend oral metronidazole (MNZ) as the first-line treatment option for vaginal trichomoniasis; however, there have been cases of prolonged symptoms or recurrence after treatment. To consider appropriate treatment strategies for refractory vaginal trichomoniasis, we conducted a retrospective cohort study. We reviewed the medical records of patients who tested positive for Trichomonas vaginalis (T. vaginalis) at the National Center for Global Health and Medicine between August 2011 and May 2023. Refractory vaginal trichomoniasis was defined as the failure after the initial MNZ treatment. During the study period, nine cases of vaginal trichomoniasis were identified, six of which were refractory to treatment for T. vaginalis. Four patients were cured with a combination of oral and vaginal tinidazole (TNZ) therapy, one with oral TNZ and one with two doses of MNZ. Possible causes of treatment failure include MNZ-resistant T. vaginalis, reinfection between partners, and infections of other sexual transmitted diseases. However, the fact that TNZ was effective suggests that MNZ-resistant T. vaginalis may have been the cause. Although MNZ resistance testing was not performed in this study, treatment with TNZ should be considered in cases of refractory vaginal trichomoniasis, possibly caused by MNZ-resistant T. vaginalis.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akiko Ohta, Shuji Hashimoto, Miyuki Kawado, Mari S Oba, Ritei Uehara, Kiyosu Taniguchi, Tomimasa Sunagawa, Masaki Nagai, Yoshitaka Murakami
{"title":"Utilizing infectious disease surveillance for epidemic warnings of respiratory syncytial virus infections in Japan from 2015 to 2019.","authors":"Akiko Ohta, Shuji Hashimoto, Miyuki Kawado, Mari S Oba, Ritei Uehara, Kiyosu Taniguchi, Tomimasa Sunagawa, Masaki Nagai, Yoshitaka Murakami","doi":"10.7883/yoken.JJID.2023.484","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2023.484","url":null,"abstract":"<p><p>Japan's National Epidemiological Surveillance of Infectious Diseases (NESID) has implemented a warning system for detecting epidemics in smaller districts, such as public health center (PHC) areas. This system is applied to influenza and pediatric infectious diseases but not to respiratory syncytial virus (RSV) infection, whose incorporation is essential for early epidemic detection. We aimed to propose criterion values for the epidemic warning system of RSV infection within PHC areas. We analyzed the weekly number of RSV infection cases reported by sentinel medical institutions (SMIs) in the NESID from 2015 to 2019. Weekly cases per SMI in the PHC area were set for an index for epidemic warnings. We determined the criteria for issuing an epidemic warning by describing the percentiles of the distribution of the index. Setting the critical values for the onset and end of the epidemic warning at 5 and 2, respectively, yielded an approximately 5% annual proportion of PHC areas with an epidemic warning. This aligns with the acceptably implemented frequency of epidemic warnings. The 5-year (2015-2019) RSV infection epidemic trend showed that the set critical values were appropriate. Using these values could help issue warnings regarding potential RSV infection epidemics in Japan.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-woven masks and SARS-CoV-2 infection in a cluster setting in Japan.","authors":"Yukari Takahashi, Soshi Takao, Tomoka Kadowaki, Naomi Matsumoto, Takashi Yorifuji","doi":"10.7883/yoken.JJID.2023.059","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2023.059","url":null,"abstract":"<p><p>Evidence about which types of mask are effective in preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We examined which mask types were effective against SARS-CoV-2 infection in a cluster setting in Japan. We retrospectively reviewed data from a cluster of COVID-19 cases that occurred at a manufacturing company in mid-August 2021. We included a total of 87 individuals who reported the type of mask worn. We dichotomized the types of mask into non-woven masks or other types of mask, such as cloth or urethane masks. We then examined the associations between the mask type and SARS-CoV-2 infection using logistic regression analysis, adjusting for potential confounders. Participants who wore non-woven masks were less likely to be infected with SARS-CoV-2 (9.7%) compared with those who wore other types of mask (26.7%). After adjusting for potential confounders, wearing a non-woven mask was significantly associated with a reduced risk of infection compared with wearing other mask types (odds ratio = 0.10, 95% confidence interval: 0.01 to 0.80). Non-woven masks were found to be more effective in preventing SARS-CoV-2 infection in a cluster setting than other types of mask, such as cloth or urethane masks.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}