Japanese journal of infectious diseases最新文献_第3页

Clinical Efficacy of Therapeutic Agents for Clostridioides difficile Infection Based on Four Severity Classifications. 基于四种严重程度分类的艰难梭菌感染治疗药物的临床疗效。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-09-19 Epub Date: 2024-03-29 DOI: 10.7883/yoken.JJID.2023.483

Mariko Ohtani, Sadako Yoshizawa, Taito Miyazaki, Eri Kumade, Shinobu Hirayama, Maki Sakamoto, Hinako Murakami, Tadashi Maeda, Yoshikazu Ishii, Takahiro Matsumoto, Kazuhiro Tateda

{"title":"Clinical Efficacy of Therapeutic Agents for Clostridioides difficile Infection Based on Four Severity Classifications.","authors":"Mariko Ohtani, Sadako Yoshizawa, Taito Miyazaki, Eri Kumade, Shinobu Hirayama, Maki Sakamoto, Hinako Murakami, Tadashi Maeda, Yoshikazu Ishii, Takahiro Matsumoto, Kazuhiro Tateda","doi":"10.7883/yoken.JJID.2023.483","DOIUrl":"10.7883/yoken.JJID.2023.483","url":null,"abstract":"Japanese guidelines recommend metronidazole (MNZ) and vancomycin (VCM) for non-severe and severe cases of Clostridioides difficile infection (CDI), respectively. In the present study, we investigated the use of CDI antimicrobials and evaluated their clinical efficacy and validity using four severity classifications. A retrospective chart review was conducted using the data of 137 inpatients with initially positive C. difficile toxin test results and the initiation of CDI antimicrobials between April 2015 and March 2019. Patients treated with VCM or oral MNZ were included for clinical efficacy analysis of CDI antimicrobials and validation of severity classifications. The endpoints were CDI recurrence, 30-day mortality, and diarrhea cure rates. No significant differences were found between the VCM and oral MNZ groups in the CDI recurrence rate (10.4% vs. 12.7%, P = 0.707), 30-day mortality rate (12.5% vs. 5.6%, P = 0.162), and diarrhea cure rate (61.9% vs. 72.7%, P = 0.238), regardless of severity. Treatment with oral MNZ for non-severe cases was promising, confirming its usefulness according to Japanese guidelines. Further investigation of the clinical efficacy of oral MNZ in patients with first-episode CDI and evaluation of the preferred severity classification are warranted.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"281-284"},"PeriodicalIF":1.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous Renal Replacement Therapy Improves Indicators and Short-Term Survival in People with AIDS Manifesting Sepsis and Acute Kidney Injury. 持续性肾脏替代疗法可改善出现败血症和急性肾损伤的艾滋病患者的指标和短期存活率。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-07-24 Epub Date: 2024-02-29 DOI: 10.7883/yoken.JJID.2023.280

Jie Zheng, Qiu-Jin Yang, Fei Qi, Han-Zhang Shen, Le Zhang, Jia-Wei Xia

{"title":"Continuous Renal Replacement Therapy Improves Indicators and Short-Term Survival in People with AIDS Manifesting Sepsis and Acute Kidney Injury.","authors":"Jie Zheng, Qiu-Jin Yang, Fei Qi, Han-Zhang Shen, Le Zhang, Jia-Wei Xia","doi":"10.7883/yoken.JJID.2023.280","DOIUrl":"10.7883/yoken.JJID.2023.280","url":null,"abstract":"Patients with acquired immune deficiency syndrome (AIDS) are susceptible to numerous complications, such as sepsis and acute kidney injury (AKI), leading to adverse outcomes. Continuous renal replacement therapy (CRRT) is becoming increasingly popular for treating sepsis and AKI. This study aimed to verify the effectiveness of CRRT in the treatment of patients with AIDS with sepsis and AKI to provide new directions for the treatment of severe AIDS. Data of 74 people with AIDS, sepsis, and AKI were collected. The patients were divided into CRRT and non-CRRT groups. There was no difference in the indicators between the two groups at admission. Vital signs, pH, serum potassium level, renal function, blood lactate level, acute physiology and chronic health evaluation II score, and sequential organ failure assessment score in the CRRT group demonstrated significant improvements over those in the non-CRRT group at both 24 and 72 h after admission (P < 0.05). The levels of interleukin 6 and procalcitonin declined more significantly in the CRRT group at 72 h after admission (P < 0.05). The CRRT group had a higher 28-day survival rate than the non-CRRT group (P < 0.05). CRRT improves the clinical indicators and increases the short-term survival rate of patients with AIDS, sepsis, and AKI.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"240-243"},"PeriodicalIF":1.3,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Course and Molecular Characterization of Human Bocavirus Associated with Acute Lower Respiratory Tract Infections in a Tertiary Care Hospital in Northern India. 印度北部三级医院中与急性下呼吸道感染相关的人类博卡病毒的临床过程和分子特征。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-07-23 Epub Date: 2024-02-29 DOI: 10.7883/yoken.JJID.2023.251

Subhabrata Sarkar, Mannat Kang, Suresh Kumar Angurana, Shankar Prasad, Ishani Bora, Pankaj Singh, Vikrant Sharma, Meenakshi Rana, Bhartendu Singh, Muralidharan Jayashree, Radha Kanta Ratho

{"title":"Clinical Course and Molecular Characterization of Human Bocavirus Associated with Acute Lower Respiratory Tract Infections in a Tertiary Care Hospital in Northern India.","authors":"Subhabrata Sarkar, Mannat Kang, Suresh Kumar Angurana, Shankar Prasad, Ishani Bora, Pankaj Singh, Vikrant Sharma, Meenakshi Rana, Bhartendu Singh, Muralidharan Jayashree, Radha Kanta Ratho","doi":"10.7883/yoken.JJID.2023.251","DOIUrl":"10.7883/yoken.JJID.2023.251","url":null,"abstract":"Respiratory samples from 139 hospitalized children were screened for the human bocavirus (HBoV) genome. Positive samples were sequenced for the partial VP1/VP2 gene followed by molecular and phylogenetic analyses. HBoV positivity was noted in 7.2% (10/139) of patients. All HBoV-positive children presented with fever, cough, and respiratory distress (90%, 9/10). Three children developed multisystemic viral illness, with one fatality. Eight children required intensive care management and five required mechanical ventilation. The nucleotide percent identity of the partial VP1/VP2 gene in the HBoV study strains ranged from 97.52% to 99.67%. Non-synonymous mutations in the VP1 protein were T591S (n = 8) and Y517S (n = 1) in the HBoV St1 strain and N475S (n = 8) and S591T (n = 2) in the HBoV St2 strain. One strain showed A556P, H556P, I561S, and M562R non-synonymous mutations. All the study strains belonged to the HBoV1 type. Seven HBoV strains belonged to the same lineage, and three belonged to another lineage. For evolutionary dynamics, GTR+I substitution model with uncorrelated relaxed lognormal clock and Bayesian Skyline tree prior showed 9.0 × 10-4 (95% highest probability density interval: 3.1 × 10-6, 2.1 × 10-3) nucleotide substitutions per site per year. Clinical suspicion and virological screening are necessary to identify HBoV infections in children.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"227-235"},"PeriodicalIF":1.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand. 泰国中部乌泰他尼府医院和社区医院尿液大肠埃希氏菌 B2 群的传播。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-07-23 Epub Date: 2024-02-29 DOI: 10.7883/yoken.JJID.2023.376

Chanihcha Anudit, Pornthip Saraisuwan, Chantana Kimterng, Chanakan Puangmanee, Nicharee Bamphensin, Anusak Kerdsin

{"title":"Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand.","authors":"Chanihcha Anudit, Pornthip Saraisuwan, Chantana Kimterng, Chanakan Puangmanee, Nicharee Bamphensin, Anusak Kerdsin","doi":"10.7883/yoken.JJID.2023.376","DOIUrl":"10.7883/yoken.JJID.2023.376","url":null,"abstract":"Escherichia coli is a Gram-negative bacterium that causes a variety of clinical infections in humans, including diarrhea, sepsis, and urinary tract infection. This bacterium is a common multidrug-resistant threat in community and hospital settings worldwide. This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and enterobacterial repetitive intergenic consensus (ERIC)-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All isolates were susceptible to nitrofurantoin, and almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. High resistance rates to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole were observed. Clermont phylogroup B2 was predominant (n = 58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n = 11), VII (n = 9), III (n = 6), and II (n = 6) were most prevalent. ERIC-PCR showed that the strains of the B2 subgroups III and V were spread between provincial and community hospitals and between hospital wards. This evidence suggests the need for comprehensive infection control monitoring, with strong active surveillance at all hospital levels.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"220-226"},"PeriodicalIF":1.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Case of Necrotizing Fasciitis and Septicemia Caused by Pigmentibacter ruber. 首例由鲁氏猪杆菌（Pigmentibacter ruber）引起的坏死性筋膜炎和败血症。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-07-23 Epub Date: 2024-02-29 DOI: 10.7883/yoken.JJID.2023.370

Ayumi Niwa, Masahiro Hayashi, Jun Yonetamari, Motohiro Nakamura, Yuta Yokobori, Sodai Yokoyama, Mizuki Ogawa, Rina Ichioka, Ryosuke Kikuchi, Hiroyuki Okura, Shinji Ogura, Nobuyuki Tetsuka, Kaori Tanaka, Hisashi Baba

引用次数: 0

Biofilm Eradication and Inhibition of Methicillin-resistant Staphylococcus Clinical Isolates by Curcumin-Chitosan Magnetic Nanoparticles 姜黄素-壳聚糖磁性纳米粒子消除生物膜并抑制耐甲氧西林葡萄球菌临床分离株

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2024.034

Humberto Antonio Salazar-Sesatty, Edeer Iván Montoya-Hinojosa, Verónica Villarreal-Salazar, Cynthia Aracely Alvizo-Baez, Adrián Camacho-Ortiz, Luis Daniel Terrazas-Armendariz, Itza Eloisa Luna-Cruz, Juan Manuel Alcocer-González, Licet Villarreal-Treviño, Samantha Flores-Treviño

{"title":"Biofilm Eradication and Inhibition of Methicillin-resistant Staphylococcus Clinical Isolates by Curcumin-Chitosan Magnetic Nanoparticles","authors":"Humberto Antonio Salazar-Sesatty, Edeer Iván Montoya-Hinojosa, Verónica Villarreal-Salazar, Cynthia Aracely Alvizo-Baez, Adrián Camacho-Ortiz, Luis Daniel Terrazas-Armendariz, Itza Eloisa Luna-Cruz, Juan Manuel Alcocer-González, Licet Villarreal-Treviño, Samantha Flores-Treviño","doi":"10.7883/yoken.jjid.2024.034","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2024.034","url":null,"abstract":"Biofilm-producing methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative Staphylococci (MR-CoNS) are a clinical challenge for the treatment of healthcare-associated infections. As alternative antimicrobial options are needed, we aimed to determine the effect of curcumin-chitosan magnetic nanoparticles on the biofilm of staphylococcal clinical isolates. MRSA and CoNS clinical isolates were identified by MALDI-TOF mass spectrometry. Antimicrobial susceptibility testing was performed by broth microdilution. Nanoparticles were synthesized by co-precipitation of magnetic nanoparticles (MNP) and encapsulation by ionotropic gelation of curcumin (Cur) and chitosan (Chi). Biofilm inhibition and eradication by nanoparticles with and without the addition of oxacillin was assessed on staphylococcal strains. Cur-Chi-MNP showed antimicrobial activity on planktonic cells of MRSA and MR-CoNS strains and inhibited biofilm of MRSA. The addition of OXA to Cur-Chi-MNP increased biofilm inhibition and eradication activity against all Staphylococci strains (p=0.0007); higher biofilm activity was observed in early biofilm stages. Cur-Chi-MNP showed antimicrobial and biofilm inhibition activity against S. aureus. The addition of OXA increased biofilm inhibition and eradication activity against all Staphylococci strains. A combination treatment of Cur-Chi-MNP and OXA could be potentially used to treat staphylococcal biofilm-associated infections in its early stages before the establishment of biofilm bacterial cells.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"64 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141198126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of human adenovirus type 3 associated with pharyngoconjunctival fever in children in Osaka, Japan during and after the COVID-19 pandemic 在 COVID-19 大流行期间和之后，日本大阪儿童中与咽结膜炎相关的人类腺病毒 3 型的流行率

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2024.035

Mei Koyama, Satoshi Hiroi, Yuki Hirai, Atsushi Kaida

{"title":"Prevalence of human adenovirus type 3 associated with pharyngoconjunctival fever in children in Osaka, Japan during and after the COVID-19 pandemic","authors":"Mei Koyama, Satoshi Hiroi, Yuki Hirai, Atsushi Kaida","doi":"10.7883/yoken.jjid.2024.035","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2024.035","url":null,"abstract":"Since the COVID-19 pandemic has affected the epidemiological pattern of pharyngoconjunctival fever (PCF) caused by human adenovirus (HAdV), the prevalence and type distribution of HAdVs associated with PCF among children in Osaka, Japan, between 2019 and 2023 have been analyzed. The number of reported PCF cases in Osaka decreased from 2020 to 2022, followed by an unprecedented increase in 2023. HAdV-C strains, including types C1, C2, and C5, were annually detected in pathogen surveillance in Osaka. HAdV-B3 was not detected for 2 years and 9 months from March 2020, and the number of detections increased from July 2023. In total, HAdV-B3 was the most frequently detected (27 of 52 strains), and genetic analysis of its hexon hypervariable regions showed that, except for one strain, the HAdV-B3 strains identified after 2022 had different amino acid substitutions compared to those identified in 2019 and 2020. These results suggest that the PCF epidemic in 2023 was predominantly caused by variant strains of HAdV-B3, and children who have not acquired immunity against HAdV-B3 between 2020 and 2022 were thought to be infected. The impact of COVID-19 on the prevalence of HAdV infections needs to be continuously evaluated through surveillance.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"45 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141189533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A descriptive epidemiology in syphilis in Tokyo, 2019-2022 2019-2022 年东京梅毒描述性流行病学

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2024.012

Yukari Murata, Atsushi Yoshida, Eriko Suzuki, Asamoe Ogawa, Konomi Murauchi, Miyoko Hoshi, Yoshiko Somura, Yoshiyuki Sugishita, Itaru Nishizuka, Kazuhisa Yoshimura

{"title":"A descriptive epidemiology in syphilis in Tokyo, 2019-2022","authors":"Yukari Murata, Atsushi Yoshida, Eriko Suzuki, Asamoe Ogawa, Konomi Murauchi, Miyoko Hoshi, Yoshiko Somura, Yoshiyuki Sugishita, Itaru Nishizuka, Kazuhisa Yoshimura","doi":"10.7883/yoken.jjid.2024.012","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2024.012","url":null,"abstract":"The number of syphilis cases in Tokyo has been found to increase in recent years. We conducted a descriptive epidemiology to elucidate the actual status of syphilis. Data on age, sex, disease stage, and presumed sexual partner of syphilis cases reported in Tokyo were tabulated and analyzed. A total of 9,419 syphilis cases have been reported between 2019 and 2022. There was a particularly sharp rise in the number of reported cases from 2021 to 2022. Comparing 2020 to 2022, the number of syphilis cases among women in their 20s, rapidly increased, more than triple. Furthermore, the number of pregnant women among syphilis cases increased in 2022. Despite the rapid increase in the number of young women with syphilis, there has been no increase in cases of congenital syphilis. One of the reasons may be that syphilis was detected early in pregnancy due to the high antenatal checkup rate in Tokyo. However, the continued incidence of syphilis among young women may increase congenital syphilis in the future. Public health strategy should include educational activities targeting high-risk populations or adolescents, early and appropriate testing, and treatment for preventing progression of syphilis.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"85 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141189534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-emerging, under-recognized zoonotic, and neglected tropical diseases in Hawaiʻi 夏威夷再次出现、认识不足的人畜共患疾病和被忽视的热带疾病

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2023.476

Rodson Zorilla, Lauren Ching, Tiana Elisara, Kenton Kramer, Vivek Ramchandra Nerurkar

{"title":"Re-emerging, under-recognized zoonotic, and neglected tropical diseases in Hawaiʻi","authors":"Rodson Zorilla, Lauren Ching, Tiana Elisara, Kenton Kramer, Vivek Ramchandra Nerurkar","doi":"10.7883/yoken.jjid.2023.476","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.476","url":null,"abstract":"Hawaiʻi, the United States’ most western geographic state in the Pacific, is intermediate between the North and South American continents and Indo-Pacific regions, including Japan. The Hawaiian Islands’ tropical environmental conditions provide favorable ecosystems for various infectious pathogens, their vectors, and reservoirs. This creates a conducive environment for-transmission of various zoonotic diseases that affect both humans and animals. Hawaiʻi has experienced an increase in outbreaks of dengue, leptospirosis, and murine typhus. Further, toxoplasmosis and neuroangiostrongyliasis cases remain prevalent throughout the state, and the putative presence of autochthonous Zika cases in a retrospective study may be of national public health concern. Understanding the factors that affect the transmission and distribution of zoonoses is necessary to identify at-risk places and populations. The One Health approach seeks to understand, report, and interpret these factors and requires collaborations between private and government institutions. One Health should focus its efforts on neglected tropical diseases (NTD) and prioritize intervention development to control and prevent the transmission of diseases that spread between animals and humans. This review will focus on the epidemiological and clinical characteristics of under-recognized zoonotic and NTD affecting Hawaiʻi: leptospirosis, murine typhus, neuroangiostrongyliasis, toxoplasmosis, dengue, and Zika infections.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"5 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141189528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nosocomial outbreak of SARS-CoV-2 in a hospital ward during the Omicron variant-dominant wave with a review of the relevant literature 奥米克龙变异主导潮期间某医院病房爆发的非典型肺炎-CoV-2疫情及相关文献综述

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2023.464

Hilary Osaka, Yasuaki Tagashira, Hiroaki Takeuchi, Yukie Tanaka, Kousuke Tanimoto, Yoshiaki Gu

{"title":"Nosocomial outbreak of SARS-CoV-2 in a hospital ward during the Omicron variant-dominant wave with a review of the relevant literature","authors":"Hilary Osaka, Yasuaki Tagashira, Hiroaki Takeuchi, Yukie Tanaka, Kousuke Tanimoto, Yoshiaki Gu","doi":"10.7883/yoken.jjid.2023.464","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.464","url":null,"abstract":"Clusters of nosocomial coronavirus disease 2019 (COVID-19) were reported globally during the recent pandemic. Unfortunately, these clusters negatively impacted inpatient morbidity, mortality, and hospital functions. Using epidemiological data and whole genome sequencing (WGS) of SARS-CoV-2, the present study investigated an outbreak of COVID-19 at a university hospital. Eight inpatients and 13 healthcare workers tested positive for SARS-CoV-2 during a one-month period. Whole genome sequencing (WGS) of the virus in 11 patients revealed that two variants of concern belonging to the Omicron sublineages, BA.2.3 and BA1.1.2, had caused the outbreak during a time when the proportion of the Omicron lineage in the community was changing. When variants of concern are undergoing mutation, a response to the outbreak should be made with multiple variants in mind, even in the absence of epidemiological data showing close contact or other potential vectors of infection, and awareness about infection prevention and control should be raised to safeguard patient safety.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"44 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141189531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0