{"title":"尼泊尔达努沙马德什省甲型肝炎病毒和戊型肝炎病毒抗体的血清流行率","authors":"Sandesh Rimal, Sabin Shrestha, Aashma Khadka, Mami Matsuda, Ryosuke Suzuki, Shyam Prakash Dumre, Basu Dev Pandey","doi":"10.7883/yoken.JJID.2024.321","DOIUrl":null,"url":null,"abstract":"<p><p>Hepatitis A virus (HAV) and hepatitis E virus (HEV) are believed to have similar routes of transmission and epidemiology in developing countries. This study investigated the seroprevalence of these pathogens among healthy individuals from the Dhanusha district of Madhesh Province, Nepal. Ninety serum samples collected between 2022 and 2023 were analyzed using enzyme-linked immunosorbent assay to detect immunoglobulin (Ig) G antibodies against HAV and HEV. Participants (median age, 23 years; range, 1-45 years) were categorized into five age groups: 1-10, 11-20, 21-30, 31-40, and 41-45 years. The prevalence of HAV and HEV IgG was 96.7% and 13.3%, respectively. All age groups showed high positivity rates for HAV antibodies. In contrast, HEV infection rates were extremely low in children but rapidly increased in adults aged >31 years. No significant correlation was observed between HAV and HEV seropositivity rates. Additional studies, including those in other areas of Nepal, are required for the nationwide serosurveillance of HAV and HEV.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"143-146"},"PeriodicalIF":1.1000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Seroprevalence of Hepatitis A and E virus Antibodies in Dhanusha, Madhesh Province, Nepal.\",\"authors\":\"Sandesh Rimal, Sabin Shrestha, Aashma Khadka, Mami Matsuda, Ryosuke Suzuki, Shyam Prakash Dumre, Basu Dev Pandey\",\"doi\":\"10.7883/yoken.JJID.2024.321\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hepatitis A virus (HAV) and hepatitis E virus (HEV) are believed to have similar routes of transmission and epidemiology in developing countries. This study investigated the seroprevalence of these pathogens among healthy individuals from the Dhanusha district of Madhesh Province, Nepal. Ninety serum samples collected between 2022 and 2023 were analyzed using enzyme-linked immunosorbent assay to detect immunoglobulin (Ig) G antibodies against HAV and HEV. Participants (median age, 23 years; range, 1-45 years) were categorized into five age groups: 1-10, 11-20, 21-30, 31-40, and 41-45 years. The prevalence of HAV and HEV IgG was 96.7% and 13.3%, respectively. All age groups showed high positivity rates for HAV antibodies. In contrast, HEV infection rates were extremely low in children but rapidly increased in adults aged >31 years. No significant correlation was observed between HAV and HEV seropositivity rates. Additional studies, including those in other areas of Nepal, are required for the nationwide serosurveillance of HAV and HEV.</p>\",\"PeriodicalId\":14608,\"journal\":{\"name\":\"Japanese journal of infectious diseases\",\"volume\":\" \",\"pages\":\"143-146\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese journal of infectious diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7883/yoken.JJID.2024.321\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of infectious diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7883/yoken.JJID.2024.321","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/31 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Seroprevalence of Hepatitis A and E virus Antibodies in Dhanusha, Madhesh Province, Nepal.
Hepatitis A virus (HAV) and hepatitis E virus (HEV) are believed to have similar routes of transmission and epidemiology in developing countries. This study investigated the seroprevalence of these pathogens among healthy individuals from the Dhanusha district of Madhesh Province, Nepal. Ninety serum samples collected between 2022 and 2023 were analyzed using enzyme-linked immunosorbent assay to detect immunoglobulin (Ig) G antibodies against HAV and HEV. Participants (median age, 23 years; range, 1-45 years) were categorized into five age groups: 1-10, 11-20, 21-30, 31-40, and 41-45 years. The prevalence of HAV and HEV IgG was 96.7% and 13.3%, respectively. All age groups showed high positivity rates for HAV antibodies. In contrast, HEV infection rates were extremely low in children but rapidly increased in adults aged >31 years. No significant correlation was observed between HAV and HEV seropositivity rates. Additional studies, including those in other areas of Nepal, are required for the nationwide serosurveillance of HAV and HEV.
期刊介绍：
Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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