Japanese journal of infectious diseases最新文献_第4页

Contents. 内容。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2025-01-01 DOI: 10.7883/yoken.JJID.2025.78.1.contents

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Comparison of viral load in the nasopharyngeal swabs of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different epidemic seasons in Gunma prefecture, Japan. 日本群马县不同流行季节SARS-CoV-2患者鼻咽拭子病毒载量比较

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-12-27 DOI: 10.7883/yoken.JJID.2024.301

Yuki Nakazawa, Hiroyuki Tsukagoshi, Ryo Shimada, Rina Kubota, Nobuhiro Saruki

{"title":"Comparison of viral load in the nasopharyngeal swabs of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different epidemic seasons in Gunma prefecture, Japan.","authors":"Yuki Nakazawa, Hiroyuki Tsukagoshi, Ryo Shimada, Rina Kubota, Nobuhiro Saruki","doi":"10.7883/yoken.JJID.2024.301","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.301","url":null,"abstract":"The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly undergone mutations since its emergence, based on which it has been assumed that there was a change in its characteristic, including virulence or antigenicity. In this study, we investigated the viral load in the nasopharyngeal samples of patients with SARS-CoV-2 in Gunma prefecture, Japan, from April 2, 2020, to April 1, 2023. The amount of virus in samples in the Omicron-variant-prevalent period was higher than that of strains detected in samples before week 50 of 2020, the B.1.1.284-prevalent period, the Alpha-variant-prevalent period, and the Delta-variant- prevalent period. Moreover, among Omicron variants, the sublineage BA.5-prevalent period showed higher amount of virus in the samples than BA.1-prevalent period and BA.2-prevalent period. Hence, the new variant may have been able to release more viruses into the nasopharyngeal samples during the process of repeated mutations, resulting in widespread infection. The amount of virus detected in the nasopharyngeal samples showed an increasing tendency with the evolution of the virus. Therefore, considering that the amount of virus in specimens is also vital factor contributing to the spread of infection, it is important to examine this factor in samples.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of host vertebrate DNA in tick species collected from vegetation in Fukuoka, Japan. 日本福冈地区植被蜱类宿主脊椎动物DNA检测。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-12-27 DOI: 10.7883/yoken.JJID.2024.170

Takayuki Kobayashi, Yuki Ashizuka

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Molecular detection of Mycobacterium leprae using RLEP-LAMP and restriction enzyme to ensure amplification specificity. 使用 RLEP-LAMP 和限制性酶对麻风分枝杆菌进行分子检测，以确保扩增特异性。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-12-27 DOI: 10.7883/yoken.JJID.2024.251

Mukul Sharma, Purna Dwivedi, Srishti Tripathi, Purushottam Patel, Pushpendra Singh

引用次数: 0

Long-term management of refractory vaginal trichomoniasis following initial metronidazole treatment failure: A case series. 甲硝唑治疗失败后难治性阴道滴虫病的长期治疗：一个病例系列。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-12-27 DOI: 10.7883/yoken.JJID.2024.255

Taketomo Maruki, Masahiro Ishikane, Masami Kurokawa, Taketo Kubo, Yusuke Miyazato, Norio Ohmagari

{"title":"Long-term management of refractory vaginal trichomoniasis following initial metronidazole treatment failure: A case series.","authors":"Taketomo Maruki, Masahiro Ishikane, Masami Kurokawa, Taketo Kubo, Yusuke Miyazato, Norio Ohmagari","doi":"10.7883/yoken.JJID.2024.255","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2024.255","url":null,"abstract":"Guidelines for sexually transmitted infections recommend oral metronidazole (MNZ) as the first-line treatment option for vaginal trichomoniasis; however, there have been cases of prolonged symptoms or recurrence after treatment. To consider appropriate treatment strategies for refractory vaginal trichomoniasis, we conducted a retrospective cohort study. We reviewed the medical records of patients who tested positive for Trichomonas vaginalis (T. vaginalis) at the National Center for Global Health and Medicine between August 2011 and May 2023. Refractory vaginal trichomoniasis was defined as the failure after the initial MNZ treatment. During the study period, nine cases of vaginal trichomoniasis were identified, six of which were refractory to treatment for T. vaginalis. Four patients were cured with a combination of oral and vaginal tinidazole (TNZ) therapy, one with oral TNZ and one with two doses of MNZ. Possible causes of treatment failure include MNZ-resistant T. vaginalis, reinfection between partners, and infections of other sexual transmitted diseases. However, the fact that TNZ was effective suggests that MNZ-resistant T. vaginalis may have been the cause. Although MNZ resistance testing was not performed in this study, treatment with TNZ should be considered in cases of refractory vaginal trichomoniasis, possibly caused by MNZ-resistant T. vaginalis.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Streptococcal Toxic Shock Syndrome Caused by a Streptococcus pyogenes emm22 Genotype with a CsrS Mutation: a Case Report. 化脓性链球菌emm22基因型伴有CsrS突变的STSS：病例报告。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-02-29 DOI: 10.7883/yoken.JJID.2023.332

Kaoru Ogawa, Jiro Kamiyama, Tadayoshi Ikebe, Shigemasa Taguchi, Kazuya Kiyota

{"title":"Streptococcal Toxic Shock Syndrome Caused by a Streptococcus pyogenes emm22 Genotype with a CsrS Mutation: a Case Report.","authors":"Kaoru Ogawa, Jiro Kamiyama, Tadayoshi Ikebe, Shigemasa Taguchi, Kazuya Kiyota","doi":"10.7883/yoken.JJID.2023.332","DOIUrl":"10.7883/yoken.JJID.2023.332","url":null,"abstract":"A previously healthy 22-year-old woman was admitted to our hospital after an out-of-hospital cardiac arrest. Spontaneous circulation was restored prior to arrival at the hospital. However, the patient's vital signs remained unstable. Vasopressors and hyperhydration therapy were administered. Computed tomography did not reveal a cause of the cardiac arrest. Antibiotics were initiated after obtaining blood culture samples. The patient was admitted to the intensive care unit (ICU). High-dose vasopressors and hyperhydration therapy were continued and fresh frozen plasma was transfused. Two hours after ICU admission, gram staining of a blood smear revealed the presence of Streptococcus, and the antibiotics were switched to penicillin G potassium and clindamycin, and immunoglobulins were administered. Extracorporeal membrane oxygenation was initiated 10 h after ICU admission owing to respiratory failure caused by fluid overload; however, the patient's condition did not improve and she died 40 h after admission. Blood culture results confirmed the presence of Streptococcus pyogenes; the T and M serotypes were unclassifiable. The emm genotype was emm22. Sequencing revealed the presence of streptococcal pyrogenic toxin genes, speA and speB, whereas speC was absent. CsrS, CsrR, and Rgg amino acid sequencing revealed the presence of a CsrS mutation.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"348-352"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Characterization of the Proinflammatory Cytokine Profile during Acute SARS-CoV-2 Infection in People with Human Immunodeficiency Virus. 人类免疫缺陷病毒感染者急性 SARS-CoV-2 感染期间促炎细胞因子的特征。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-06-28 DOI: 10.7883/yoken.JJID.2024.184

Alitzel Anzurez, Lucky Runtuwene, Thi Thu Thao Dang, Kaori Nakayama-Hosoya, Michiko Koga, Yukihiro Yoshimura, Hiroaki Sasaki, Nobuyuki Miyata, Kazuhito Miyazaki, Yoshimasa Takahashi, Tadaki Suzuki, Hiroshi Yotsuyanagi, Natsuo Tachikawa, Tetsuro Matano, Ai Kawana-Tachikawa

{"title":"Characterization of the Proinflammatory Cytokine Profile during Acute SARS-CoV-2 Infection in People with Human Immunodeficiency Virus.","authors":"Alitzel Anzurez, Lucky Runtuwene, Thi Thu Thao Dang, Kaori Nakayama-Hosoya, Michiko Koga, Yukihiro Yoshimura, Hiroaki Sasaki, Nobuyuki Miyata, Kazuhito Miyazaki, Yoshimasa Takahashi, Tadaki Suzuki, Hiroshi Yotsuyanagi, Natsuo Tachikawa, Tetsuro Matano, Ai Kawana-Tachikawa","doi":"10.7883/yoken.JJID.2024.184","DOIUrl":"10.7883/yoken.JJID.2024.184","url":null,"abstract":"Persistent inflammation during chronic human immunodeficiency virus (HIV) infection may affect the immune response against severe acute respiratory syndrome-coronavirus 2 (SARS- CoV-2) infection. Plasma levels of multiple proinflammatory cytokines during acute SARS-CoV-2 infection were measured in people with HIV (PWH) with effective combination antiretroviral therapy. There were no significant differences in any of the measured cytokines between severity levels of coronavirus disease 2019 (COVID-19) in PWH, while most were significantly higher in HIV-uninfected individuals with severe COVID-19, suggesting that excess cytokines release by hyperinflammatory responses do not occur in individuals with severe COVID-19 with HIV infection. The strong associations between the cytokines observed in HIV-uninfected individuals, particularly between IFN-α/TNF-α and other cytokines, were lost in PWH. The steady-state plasma levels of IP-10, ICAM-1, and CD62E were significantly higher in PWH, indicating that they were in an enhanced inflammatory state. The absence of several inter-cytokine correlations was observed in in vitro lipopolysaccharide stimulus-driven cytokine production in PWH. These data suggest that inflammatory responses during SARS-CoV-2 infection in PWH are distinct from those in HIV-uninfected individuals, partially because of the underlying inflammatory state and/or impairment of innate immune cells.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"301-310"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Time from Admission to the Onset of Methicillin-Resistant Staphylococcus aureus Bacteremia in a Single Acute Care Hospital in Japan. 日本一家急诊医院从入院到出现耐甲氧西林金黄色葡萄球菌菌血症的时间。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-07-31 DOI: 10.7883/yoken.JJID.2024.159

Nobumasa Okumura, Shinya Tsuzuki, Jiefu Yu, Sho Saito, Norio Ohmagari

{"title":"Time from Admission to the Onset of Methicillin-Resistant Staphylococcus aureus Bacteremia in a Single Acute Care Hospital in Japan.","authors":"Nobumasa Okumura, Shinya Tsuzuki, Jiefu Yu, Sho Saito, Norio Ohmagari","doi":"10.7883/yoken.JJID.2024.159","DOIUrl":"10.7883/yoken.JJID.2024.159","url":null,"abstract":"The spread of antimicrobial resistant organisms (AROs) poses a major threat to animal and human health. In Japan, the estimated disability-adjusted life years (DALYs) due to ARO infections is 137.9 per 100,000 persons, with methicillin-resistant Staphylococcus aureus (MRSA) being the main contributor. Factors that can contribute to DALYs in Japan include younger age and a higher number of deaths in patients with MRSA bacteremia. Moreover, longer hospital stays may contribute to the higher rates of MRSA bacteremia in Japan than in western countries. We reviewed the diagnostic procedure combination data collected from January 1, 2016 to December 31, 2020, in an acute care hospital in Tokyo, Japan. We found that the median time from admission to MRSA bacteremia onset was 26 days, which is longer than that observed in western countries however similar to that in South Korea. Furthermore, our cohort was older than those in the United States and South Korea, potentially contributing to the higher number of years of life lost in Japan. These results underscore the need to develop strategies to reduce hospitalization rates in Japan. Larger multicenter studies are needed to comprehensively evaluate the economic and health burdens of MRSA bacteremia in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"345-347"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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An Analysis of Factors Contributing to Household Transmission of COVID-19 Using Data from Active Epidemiological Investigations Performed in the Setagaya Ward of Tokyo, Japan. 利用在日本东京世田谷区开展的主动流行病学调查数据，分析导致 COVID-19 家庭传播的因素。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-06-28 DOI: 10.7883/yoken.JJID.2023.342

Mutsumi Kadowaki, Keiko Yasuoka, Chika Takahashi, Haruko Mukoyama, Yoshihisa Shirayama, Motoyuki Yuasa

{"title":"An Analysis of Factors Contributing to Household Transmission of COVID-19 Using Data from Active Epidemiological Investigations Performed in the Setagaya Ward of Tokyo, Japan.","authors":"Mutsumi Kadowaki, Keiko Yasuoka, Chika Takahashi, Haruko Mukoyama, Yoshihisa Shirayama, Motoyuki Yuasa","doi":"10.7883/yoken.JJID.2023.342","DOIUrl":"10.7883/yoken.JJID.2023.342","url":null,"abstract":"An active epidemiological investigation of COVID-19 cases in the Setagaya Ward of Tokyo revealed that household transmission was the main route of spread. This study aimed to identify factors associated with household transmission in patients diagnosed with COVID-19 and cohabitants, during the wild-type (WT) (December 2020) and Alpha-variant (AV) (May 2021) epidemics. Factors in index cases significantly associated with household transmission of both WT and AV virus, included more than 3 days from onset to diagnosis (WT: risk ratio [RR] 1.44, 95% confidence interval [CI] 1.16-1.79; AV: RR 1.66, 95% CI 1.32-2.08), and a household size of three or more (WT: RR 1.37, 95% CI 1.10-1.72; AV: RR 1.29, 95% CI 1.05-1.59). Household transmission of WT was also significantly associated with the index case being aged ≥65 years (RR 2.39, 95% CI 1.26-4.54) and symptomatic at diagnosis (RR 3.05, 95% CI 1.22-7.63). Among cohabitants, factors associated with household transmission included being the spouse/partner of the index case (WT: RR 1.68, 95% CI 1.34-2.10; AV: RR 1.97, 95% CI 1.59-2.43) and at least 3 days from onset to diagnosis of the index case (WT: RR 1.48, 95% CI 1.21-1.82; AV: RR 1.86, 95% CI 1.52-2.28). Early diagnosis and isolation are effective for preventing household transmission.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"317-324"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter pylori vacA Allelic Combination, dupA, cagE and cagA Genotypes and Their Associations with Gastric Diseases in the Moroccan Population. 幽门螺杆菌 vacA 等位基因组合、dupA、cagE 和 cagA 基因型及其与摩洛哥人胃病的关系。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-06-28 DOI: 10.7883/yoken.JJID.2024.061

Souad Oirdi Zahir, Mounia El Khadir, Samia Alaoui Boukhris, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Mohamed El Abkari, Bahia Bennani

{"title":"Helicobacter pylori vacA Allelic Combination, dupA, cagE and cagA Genotypes and Their Associations with Gastric Diseases in the Moroccan Population.","authors":"Souad Oirdi Zahir, Mounia El Khadir, Samia Alaoui Boukhris, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Mohamed El Abkari, Bahia Bennani","doi":"10.7883/yoken.JJID.2024.061","DOIUrl":"10.7883/yoken.JJID.2024.061","url":null,"abstract":"This study aimed to investigate the combination of the four regions of Helicobacter pylori vacA with cagA, cagE, dupA genes and cagA-EPIYA motifs to identify the most likely combination that could be used as a disease determinant marker in the Moroccan population. A total of 838 H. pylori-positive samples were obtained from consenting patients, that were previously analyzed by PCR to characterize vacA-s, -m, and -i regions; cagE status; and cagA 3' region polymorphism, were used to characterize vacA-d region and to determine dupA gene status. The analysis showed the predominance of the less virulent combination {vacA(s2m2i2d2)dupA(-)cagE(-)cagA(-)}, and showed that the risk of gastric cancer is 13.33 fold higher (95% confidence interval [CI] = 1.06-166.37) in patients infected with strains harboring vacA(s1m1i1d1)dupA(-)cagE(+)cagA(2EPIYA-C) compared to patients with gastritis without lesions and infected by H. pylori strains harboring vacA(s2m2i2d2)dupA(-) cagE(-)cagA(-). Infection with strains harboring the vacA(s1m1i1d1)dupA(+)cagE(+)cagA(1EPIYA-C) genotype combination represented a risk factor for both gastric ulcer and duodenal ulcer than gastritis without lesions; odds ratio (OR) =16 (95% CI = 1.09-234.24) and OR = 12.39 (95% CI = 1.09-140.81), respectively. These results suggest that the combination of the active form of vacA genotypes, dupA gene status, and the number of EPIYA-C motifs may be helpful markers for discriminating between several gastric diseases.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"325-333"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0