Japanese journal of infectious diseases最新文献_第4页

Characteristics of Group A Streptococcus M1 and Non-M1 Isolates from Adult and Pediatric Populations in Central Japan, 2024-2025: sic Nucleotide Alleles with CovS Amino Acid Mutations in M1 Clones. 2024-2025年日本中部成人和儿童A群M1或非M1链球菌分离株的特征：M1克隆CovS氨基酸突变的sic核苷酸等位基因

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-07-23 Epub Date: 2025-11-28 DOI: 10.7883/yoken.JJID.2025.151

Yuzo Tsuyuki, Takashi Takahashi, Mieko Goto, Haruno Yoshida, Yuka Nakamura, Takahiro Maeda

{"title":"Characteristics of Group A Streptococcus M1 and Non-M1 Isolates from Adult and Pediatric Populations in Central Japan, 2024-2025: sic Nucleotide Alleles with CovS Amino Acid Mutations in M1 Clones.","authors":"Yuzo Tsuyuki, Takashi Takahashi, Mieko Goto, Haruno Yoshida, Yuka Nakamura, Takahiro Maeda","doi":"10.7883/yoken.JJID.2025.151","DOIUrl":"10.7883/yoken.JJID.2025.151","url":null,"abstract":"We aimed to specify the characteristics of group A Streptococcus M1 (n = 23) or non-M1 (n = 282) isolates from adult (n = 176) and pediatric (n = 129) populations in central Japan, October 2024-April 2025. Of the 14 speA-possessing non-M1 isolates, there were seven emm3.93 isolates from 6 non-invasive samples of pediatric patients and 1 invasive specimen of an adult patient. We found the distribution of M1 clones containing M1global (n = 1), M113snps (n = 4), or M1UK (n = 18) lineages in the central Japan region consisting of Tokyo, Chiba, Tochigi, Saitama and Kanagawa. The M1 clones were from 21 non-invasive samples of pediatric/adult patients and 2 invasive specimens from adult patients. Additionally, we determined the sic nucleotide alleles and observed the M1global/M113snps/M1UK sic clustering. Of the CovS amino acid (AA) mutations among M1, there was an insertion of transposase (ISAs1-like IS1548 transposase, 377 AA) into the CovS histidine kinase-like ATPase domain (following AA position 458) of one invasive M1UK isolate. Our observations suggest that CovS AA mutations in invasive isolates with M1UK should be specified within the four functional domains of CovS to evaluate their hypervirulent properties.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"150-161"},"PeriodicalIF":1.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Vertebral Osteomyelitis with an Erector Spinae Abscess Caused by Staphylococcus argenteus ST1223. 由阿根廷葡萄球菌ST1223引起的椎体骨髓炎伴竖脊脓肿1例。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-07-23 Epub Date: 2025-09-30 DOI: 10.7883/yoken.JJID.2025.116

Yusuke Watanabe, Naoto Takenoshita, Maki Tsuchiya, Yuri Miura, Kohji Komori, Tetsuo Yamaguchi, Itaru Nakamura, Hidehiro Watanabe, Soichiro Shimizu

{"title":"A Case of Vertebral Osteomyelitis with an Erector Spinae Abscess Caused by Staphylococcus argenteus ST1223.","authors":"Yusuke Watanabe, Naoto Takenoshita, Maki Tsuchiya, Yuri Miura, Kohji Komori, Tetsuo Yamaguchi, Itaru Nakamura, Hidehiro Watanabe, Soichiro Shimizu","doi":"10.7883/yoken.JJID.2025.116","DOIUrl":"10.7883/yoken.JJID.2025.116","url":null,"abstract":"Staphylococcus argenteus is a novel bacterial species distinct from Staphylococcus aureus. Nevertheless, S. argenteus is often misidentified as S. aureus because they cannot be differentiated easily using routine diagnostic microbiology methods. An 81-year-old man was admitted because of persistent lumbar pain and fever. Strains from his blood cultures were initially identified as methicillin-susceptible S. aureus. Enhanced computed tomography revealed an erector spinae abscess connected with the L5 transverse process, and magnetic resonance imaging of the lumbar region showed a high intensity of L1 and L5 on short tau inversion recovery. The abovementioned pathogen was also cultured from the aspiration fluid of the abscess. Therefore, the patient was diagnosed with vertebral osteomyelitis with an erector spinae abscess. We analyzed the detected strain using matrix-assisted laser desorption ionization time-of-flight mass spectrometry and whole-genome sequencing, re-identifying the strain as S. argenteus sequence type (ST) 1223. Although S. argenteus ST1223 has mainly enteric pathogenicity, our case suggests its potential to invade the musculoskeletal system. Its pathogenicity was similar to or greater than that of S. aureus in both previous studies and our case. Therefore, the clinical differentiation of S. argenteus and S. aureus warrants further investigation.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"162-164"},"PeriodicalIF":1.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value of Routine Laboratory Tests in Hemorrhagic Fever with Renal Syndrome in Jiaodong Peninsula, Shandong Province, China. 胶东半岛肾综合征出血热常规实验室检查的诊断价值

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-07-23 Epub Date: 2025-11-28 DOI: 10.7883/yoken.JJID.2025.022

Wenfei Lu, Qianqian Sun, Wenyao Wu, Chao Zhu, Yangang Wei, Lin Sun, Limin Lun, Jinxia Zhao

{"title":"Diagnostic Value of Routine Laboratory Tests in Hemorrhagic Fever with Renal Syndrome in Jiaodong Peninsula, Shandong Province, China.","authors":"Wenfei Lu, Qianqian Sun, Wenyao Wu, Chao Zhu, Yangang Wei, Lin Sun, Limin Lun, Jinxia Zhao","doi":"10.7883/yoken.JJID.2025.022","DOIUrl":"10.7883/yoken.JJID.2025.022","url":null,"abstract":"To explore the clinical value of routine laboratory tests in the early diagnosis of hemorrhagic fever with renal syndrome (HFRS), this study retrospectively analyzed the medical records of 146 patients, including 87 HFRS cases and 59 controls. Subsequently, a multivariable logistic regression model was employed to identify clinically relevant indicators for HFRS diagnosis. The sensitivity and specificity of these indicators were further evaluated using receiver operating characteristic (ROC) curve analysis, both individually and in combination. Results showed that HFRS patients had significantly higher levels of leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, red blood cells, urinary proteins, and hemoglobin (Hb) (all P < 0.05), while platelet counts were lower (P < 0.05). Multivariable logistic regression analysis revealed that monocyte count and Hb were independent predictors of HFRS. The area under the ROC curve (AUC) for the combined use of monocyte count and Hb level in diagnosing HFRS was 0.942, which was significantly higher than the AUC when either was used alone, indicating excellent predictive performance. In conclusion, elevated monocyte count and Hb levels are independent predictors of HFRS. Their combined use enables effective prediction of HFRS and may serve as a key criterion for the early diagnosis of HFRS in primary care settings.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"138-142"},"PeriodicalIF":1.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Infection Caused by a Hypervirulent ST367-KL1 Klebsiella quasipneumoniae subsp. similipneumoniae: First Case Report in Japan. 高毒力ST367-KL1拟肺炎克雷伯菌亚种致侵袭性感染类似肺炎：日本首例病例报告。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-06-30 DOI: 10.7883/yoken.JJID.2026.079

Shogo Saito, Satoko Nakashima, Kentaro Endo, Kazuya Narita, Yuji Hatakeyama, Yuji Suzuki, Ryuichi Nakano, Yuki Suzuki, Hisakazu Yano, Tohru Fujiwara, Kiwamu Nakamura

{"title":"Invasive Infection Caused by a Hypervirulent ST367-KL1 Klebsiella quasipneumoniae subsp. similipneumoniae: First Case Report in Japan.","authors":"Shogo Saito, Satoko Nakashima, Kentaro Endo, Kazuya Narita, Yuji Hatakeyama, Yuji Suzuki, Ryuichi Nakano, Yuki Suzuki, Hisakazu Yano, Tohru Fujiwara, Kiwamu Nakamura","doi":"10.7883/yoken.JJID.2026.079","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.079","url":null,"abstract":"Klebsiella quasipneumoniae is a member of the Klebsiella pneumoniae complex that is difficult to distinguish from K. pneumoniae using conventional laboratory methods, and information on its clinical manifestations is limited. We describe the first known case of invasive infection with hypervirulent K. quasipneumoniae subsp. similipneumoniae in Japan. A 65-year-old woman with pancreatogenic diabetes mellitus presented with fever and nausea. Computed tomography revealed a liver abscess and multiple pulmonary nodules with cavitation suggestive of septic pulmonary emboli. Blood cultures yielded an isolate identified as K. pneumoniae complex. Whole-genome sequencing (WGS) subsequently identified the isolate as K. quasipneumoniae subsp. similipneumoniae, sequence type 367 (ST367) and capsular type K1 (KL1). The isolate exhibited a hypermucoviscous phenotype and harbored the virulence-associated genes iroBCDN, iucABCD/iutA, rmpA/A2, and peg-344. The patient improved following antimicrobial therapy with meropenem for 10 days, followed by cefmetazole for 13 days, and was discharged home after a hospital stay of 81 days. This case highlights the potential for invasive infection caused by hypervirulent K. quasipneumoniae, the usefulness of WGS for species identification, and the need for ongoing clinical and genomic surveillance to monitor the emergence of this pathogen.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung regulatory T cells and inflammatory mediators associate with heterogeneous outcomes in a SARS-CoV-2 infected mouse model. 在SARS-CoV-2感染小鼠模型中，肺调节性T细胞和炎症介质与异质性结果相关

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-06-30 DOI: 10.7883/yoken.JJID.2026.077

Chatherine Silas Mtali, Rise Kurokawa, Thorbjorg Einarsdottir, Innocent John Daniel, Cassian Germanus Mwinuka, Takushi Nomura

{"title":"Lung regulatory T cells and inflammatory mediators associate with heterogeneous outcomes in a SARS-CoV-2 infected mouse model.","authors":"Chatherine Silas Mtali, Rise Kurokawa, Thorbjorg Einarsdottir, Innocent John Daniel, Cassian Germanus Mwinuka, Takushi Nomura","doi":"10.7883/yoken.JJID.2026.077","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.077","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to heterogeneous clinical outcomes, suggesting that dysregulated host immune responses and inflammation contribute to divergent disease trajectories. We examined early immune correlates of disease severity using 32-week-old C57BL/6J mice and evaluated whether modulation of regulatory T cells (Tregs) would alter disease outcome. Oral administration of the CDK8/19 inhibitor AS2863619 did not markedly improve early weight loss, gross lung inflammatory scores, bronchoalveolar lavage fluid (BALF) viral RNA levels, or histopathological findings. Despite this limited impact on clinical outcomes, AS2863619 increased the frequency of KLRG1+ subsets in lung Foxp3+ CD4+ Tregs at 5 days post-infection. Across infected animals, lung Foxp3+ CD4+ Treg numbers inversely correlated with early weight loss. In parallel, several BALF inflammatory cytokines and chemokines were associated with disease severity, and the frequency of KLRG1+ Tregs inversely correlated with multiple inflammatory mediators. These findings indicate that endogenous lung Treg numbers and KLRG1+ Treg frequencies were linked to a less inflammatory airway milieu during acute SARS-CoV-2 infection.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of a Novel ELISA and Immunochromatography Assay for Tetanus Antibody Detection. 一种新型破伤风抗体ELISA和免疫层析检测方法的验证。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-06-30 DOI: 10.7883/yoken.JJID.2026.006

Chiyomi Sakamoto, Kohsuke Kumeda, Mariko Nakamichi, Chie Shitada, Susumu Yamaori, Motohide Takahashi

{"title":"Validation of a Novel ELISA and Immunochromatography Assay for Tetanus Antibody Detection.","authors":"Chiyomi Sakamoto, Kohsuke Kumeda, Mariko Nakamichi, Chie Shitada, Susumu Yamaori, Motohide Takahashi","doi":"10.7883/yoken.JJID.2026.006","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.006","url":null,"abstract":"We developed a highly sensitive and reproducible enzyme-linked immunosorbent assay (ELISA) and a qualitative immunochromatography (IC) test to specifically measure antibodies against tetanus toxoid. These methods detect tetanus antibodies in human, mouse, rabbit, and horse sera. These assays demonstrated high accuracy and precision for mouse and human samples. Using the developed ELISA, we quantified tetanus antibody titers in a mouse immunization model (tetanus toxoid potency test) and in human samples. The relative potency of tetanus toxoid calculated from ELISA titers was comparable to that determined by the traditional in vivo toxin challenge method. In human pooled plasma, ELISA titers correlated strongly with neutralizing antibody titers (r = 0.9826), enabling the estimation of the latter. Furthermore, ELISA titers correlated highly with results from the Kaketsuken particle agglutination method (r = 0.9866) and the novel IC (r = 0.8209). These findings demonstrate the utility of these methods for evaluating vaccine efficacy and immune responses, suggesting broad applications in basic research and clinical settings.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre- vaccination seroprevalence of rubella IgM among women of child bearing age in southeast Nigeria: a five-year cross-sectional study. 尼日利亚东南部育龄妇女接种疫苗前风疹IgM血清流行率：一项为期五年的横断面研究。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-06-30 DOI: 10.7883/yoken.JJID.2025.266

Chinedu Michael Chukwubike, Chioma Uju Benjamin-Puja, Constance Ugochi Azubuike, Chioma Chinyere Edu-Alamba, Elezuo Okorie Elezuo, Chuma Emembolu, Ogbonna Nwabeke, Okechukwu Ogbodo, Hyacinth Egbuna, Princess Ada Ojeanyah, Jennifer Ifeoma Ajaegbu, Chinenye Ibeh, Oluchi Obioma Adighogu, Chika David Okudoh, Roseline Adolphus-Chukwuemeka, Leonard Ihedioha, Abudullahi Salihu, Blessing Ekanem, Martin Chukwuji, Olajumoke Babatunde, Mary Indyeriyo-Kaan Dooshima

{"title":"Pre- vaccination seroprevalence of rubella IgM among women of child bearing age in southeast Nigeria: a five-year cross-sectional study.","authors":"Chinedu Michael Chukwubike, Chioma Uju Benjamin-Puja, Constance Ugochi Azubuike, Chioma Chinyere Edu-Alamba, Elezuo Okorie Elezuo, Chuma Emembolu, Ogbonna Nwabeke, Okechukwu Ogbodo, Hyacinth Egbuna, Princess Ada Ojeanyah, Jennifer Ifeoma Ajaegbu, Chinenye Ibeh, Oluchi Obioma Adighogu, Chika David Okudoh, Roseline Adolphus-Chukwuemeka, Leonard Ihedioha, Abudullahi Salihu, Blessing Ekanem, Martin Chukwuji, Olajumoke Babatunde, Mary Indyeriyo-Kaan Dooshima","doi":"10.7883/yoken.JJID.2025.266","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.266","url":null,"abstract":"Rubella is an acute, contagious viral illness that is generally mild, yet infection during early pregnancy can cause congenital rubella syndrome (CRS), a serious condition associated with deafness, blindness, congenital heart defects, and developmental disabilities. Although vaccination is the only effective preventive measure, rubella continues to circulate in regions with low immunization coverage. This study assessed the pre-vaccination seroprevalence of rubella IgM antibodies among women of reproductive age in Southeast Nigeria. A retrospective cross-sectional study was conducted from 2020 to 2024 among 405 women aged 15-49 years across five states in Southeast Nigeria. Serum samples were tested for rubella IgM antibodies using ELISA. Rubella IgM seroprevalence was 6.7% (27/405). Adolescents, 15-19 years had the highest positivity (11.7%), with prevalence declining steadily with age to 1.9% among women aged 30-34 years. Rubella positivity peaked in 2020 (16.0%) and 2024 (14.5%), with Imo State showing the highest prevalence (10.1%) and an incidence of 7.3 per 1,000,000 population. Rubella IgM positivity among women of childbearing age indicates ongoing transmission and susceptibility, particularly among adolescents. These findings provide baseline data for assessing vaccine impact and highlight the need for stronger surveillance and improved uptake to prevent CRS in Nigeria.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-prefecture rubella outbreak associated with technical intern training for foreign workers in Japan, 2016: Implications for sustaining rubella elimination verified in 2025. 2016年日本与外籍工人技术实习培训相关的多县风疹疫情：对2025年持续消除风疹的影响

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-06-30 DOI: 10.7883/yoken.JJID.2026.071

Yusuke Kobayashi, Hajime Kamiya, Munehisa Fukusumi, Saeko Morino, Tomimasa Sunagawa, Keiko Tanaka-Taya, Yoshio Mori, Kazunori Oishi

{"title":"A multi-prefecture rubella outbreak associated with technical intern training for foreign workers in Japan, 2016: Implications for sustaining rubella elimination verified in 2025.","authors":"Yusuke Kobayashi, Hajime Kamiya, Munehisa Fukusumi, Saeko Morino, Tomimasa Sunagawa, Keiko Tanaka-Taya, Yoshio Mori, Kazunori Oishi","doi":"10.7883/yoken.JJID.2026.071","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2026.071","url":null,"abstract":"Rubella elimination in Japan was verified in September 2025; however, importation and immunity gaps can still precipitate outbreaks. We investigated a multi-prefecture rubella outbreak in 2016 linked to an introductory training course for foreign workers. After a rubella case was reported in Saitama Prefecture on June 6, 2016, we investigated the training facility and conducted active nationwide surveillance. We collected roster and dispatch information, monitored cases reported to the National Epidemiological Surveillance of Infectious Diseases, and interviewed trainees, host-company staff. Ninety-two trainees were dispatched to 41 companies in 23 prefectures. Thirteen rubella cases were identified. Ten patients were Vietnamese trainees, nine were likely infected during group training, and one was suspected to have imported rubella from Vietnam. Three individuals were likely infected at host companies, including two Japanese supervisors. No patient had documented records of a rubella-containing vaccine. Viruses from three cases belonged to genotype 2B. A single importation into a congregate training setting can rapidly create multi-prefecture exposure. Vaccination and/or verification of immune status among incoming trainees and susceptible host-company workers is essential to prevent similar events and sustain rubella elimination in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease burden and quality of life in caregivers of infants with RSV lower respiratory tract infections in Japan. 日本RSV下呼吸道感染婴儿护理人员的疾病负担和生活质量

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-06-30 DOI: 10.7883/yoken.JJID.2025.284

Ataru Igarashi, Koo Nagasawa, Demont Clarisse, Takeshi Arashiro, Yuriko Hagiwara, Mihoko Ohata, Misako Ohkusu, Noriko Takeuchi, Kenichi Shizuno, Erika Kurihara, Misato Yoshida, Takahiro Kodama, Katsuaki Abe, Tadashi Hoshino, Kenichi Takeshita, Junko Arii, Haruka Hishiki, Setsuo Ota, Yoshiko Takahashi, Yuko Omata, Tomoko Nakazawa, Tomohiro Someya, Naruhiko Ishiwada

{"title":"Disease burden and quality of life in caregivers of infants with RSV lower respiratory tract infections in Japan.","authors":"Ataru Igarashi, Koo Nagasawa, Demont Clarisse, Takeshi Arashiro, Yuriko Hagiwara, Mihoko Ohata, Misako Ohkusu, Noriko Takeuchi, Kenichi Shizuno, Erika Kurihara, Misato Yoshida, Takahiro Kodama, Katsuaki Abe, Tadashi Hoshino, Kenichi Takeshita, Junko Arii, Haruka Hishiki, Setsuo Ota, Yoshiko Takahashi, Yuko Omata, Tomoko Nakazawa, Tomohiro Someya, Naruhiko Ishiwada","doi":"10.7883/yoken.JJID.2025.284","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.284","url":null,"abstract":"The economic burden of respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) and caregiver quality of life (QOL) were assessed in a population-based epidemiological study of infant RSV LRTI in Chiba, Japan. Medical costs were calculated based on diagnosis procedure data, and multiplied by the average number of hospitalization days. Outpatient medical costs were calculated as the cost per visit and laboratory fees. Productivity loss was calculated by multiplying the number of days spent in the care of guardians. The QOL of caregivers was assessed by directly administering the EuroQol five-dimensional-five-level (EQ-5D-5L) questionnaire to guardians. These data can be extrapolated to the national level, estimating an overall economic burden of JPY 5.3 billion, including JPY 2.5 billion in medical expenses and JPY 2.8 billion in productivity loss. Low QOL scores were observed, with 70-80% of respondents experiencing issues in the \"anxiety and depression\" and \"usual activity\" including mobility and self-care dimensions of the EQ-5D-5L scale. Stratified analysis revealed lower QOL scores among those with RSV infection. RSV LRTI imposes a significant social and economic burden on children and their caregivers. This information could be instrumental in advancing discussions on RSV preventive measures in the National Immunization Program.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Hematological and Biochemical Biomarkers for Predicting Dengue Severity in Children. 预测儿童登革热严重程度的血液学和生化生物标志物的比较。

IF 1.1 4区医学

Japanese journal of infectious diseases Pub Date : 2026-05-29 DOI: 10.7883/yoken.JJID.2025.093

Agustin Iskandar, Jason Wiliam, Aurelia Bunanta, Christopher Chang, Irene Ratri Dewi

{"title":"Comparison of Hematological and Biochemical Biomarkers for Predicting Dengue Severity in Children.","authors":"Agustin Iskandar, Jason Wiliam, Aurelia Bunanta, Christopher Chang, Irene Ratri Dewi","doi":"10.7883/yoken.JJID.2025.093","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2025.093","url":null,"abstract":"Dengue remains a global health concern, especially in tropical regions like Indonesia. As of July 2024, there were 149,866 reported cases and 844 deaths, with children aged 0-14 years accounting for 63% of fatalities. Dengue presents a wide clinical spectrum, ranging from asymptomatic infection to Severe Dengue. Early detection of Severe Dengue still heavily relies on clinical warning signs, which are often unreliable. This study aimed to identify potential biomarkers to predict Dengue severity in children. An observational study using secondary data from medical records at RSSA Malang (2014-2022) was conducted, involving 304 pediatric patients (161 Severe Dengue, 143 Non-Severe Dengue). Patient characteristics such as gender, age, weight, nutritional status, and hospital stay duration showed no significant correlation with severity. However, significant differences were found in several biomarkers, notably SGOT, SGPT, ΔHb, PT, albumin, platelets, monocytes, and NLR. SGPT (AUC 0.894; OR 24.3) and SGOT (AUC 0.884; OR 16.148) emerged as the most predictive biomarkers. SGPT showed the highest diagnostic performance with 73% sensitivity, 90% specificity, and a cut-off value ≥52 µ/dL, indicating a 24.3-fold increased risk for Severe Dengue. SGPT may serve as a reliable early indicator of severity in pediatric Dengue cases.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0