Japanese journal of infectious diseases最新文献_第10页

Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins 针对 18 种深渊病毒糖蛋白的抗体的交叉中和活性

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.400

Yusuke Inoue, Yoshihiro Kaku, Michiko Harada, Keita Ishijima, Yudai Kuroda, Kango Tatemoto, Milagros Virhuez-Mendoza, Ayano Nishino, Tsukasa Yamamoto, Satoshi Inoue, Aya Matsuu, Ken Maeda

{"title":"Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins","authors":"Yusuke Inoue, Yoshihiro Kaku, Michiko Harada, Keita Ishijima, Yudai Kuroda, Kango Tatemoto, Milagros Virhuez-Mendoza, Ayano Nishino, Tsukasa Yamamoto, Satoshi Inoue, Aya Matsuu, Ken Maeda","doi":"10.7883/yoken.jjid.2023.400","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.400","url":null,"abstract":"Some lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with expression plasmids of the glycoproteins of all 18 lyssaviruses were prepared, and cross-reactivity was evaluated via virus-neutralization tests using RABV, European bat lyssavirus-1 (EBLV-1), Duvenhage virus (DUVV), Mokola virus (MOKV), and Lagos bat virus (LBV). The sera against RABV vaccines showed cross-reactivity with EBLV-1 and DUVV, which both belong to phylogroup I. However, the reactivity with MOKV and LBV in phylogroup II was notably limited or below the detection level. Next, we compared the cross-reactivity of the polyclonal antibodies against all the lyssavirus glycoproteins. Polyclonal antibodies had high virus-neutralization titers against the same phylogroup<tt>,</tt> but not against different phylogroups. Our findings indicate that a new vaccine should be developed for pre- and post-exposure prophylaxis against lyssavirus infections. \u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"115 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017–2022 2017-2022 年 COVID-19 前后东日本人类偏肺病毒的分子流行病学

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.350

Kazuya Shirato, Reiko Suwa, Naganori Nao, Miyuki Kawase, Satoko Sugimoto, Yohei Kume, Mina Chishiki, Takashi Ono, Hisao Okabe, Sakurako Norito, Masatoki Sato, Hiroko Sakuma, Shigeo Suzuki, Mitsuaki Hosoya, Makoto Takeda, Koichi Hashimoto

{"title":"Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017–2022","authors":"Kazuya Shirato, Reiko Suwa, Naganori Nao, Miyuki Kawase, Satoko Sugimoto, Yohei Kume, Mina Chishiki, Takashi Ono, Hisao Okabe, Sakurako Norito, Masatoki Sato, Hiroko Sakuma, Shigeo Suzuki, Mitsuaki Hosoya, Makoto Takeda, Koichi Hashimoto","doi":"10.7883/yoken.jjid.2023.350","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.350","url":null,"abstract":"Human metapneumovirus (hMPV) is genetically classified into two major subgroups, A and B, based on attachment glycoprotein (G) gene sequences, and the A2 subgroup is further separated into three subdivisions A2a, A2b (A2b1), and A2c (A2b2). The appearance of subgroup A2c viruses carrying a 180- or 111-nucleotide duplication in the G gene (A2c180nt-dup or A2c111nt-dup) have been reported in Japan and Spain. The pandemic of coronavirus disease 2019 (COVID-19) disrupted the epidemiological kinetics of other respiratory viruses, including hMPV. In this study, we analysed the sequences of hMPV isolates obtained from 2017 to 2022 in Tokyo and Fukushima, i.e., before and after COVID-19. Subgroup A hMPVs were detected in 2017 to 2019, and most cases were A2c111nt-dup, suggesting there was continuous momentum of this clade, identical to the global situation. Subgroup B, but not subgroup A, viruses were detected in 2022, after the COVID-19 peak. Phylogenetic analysis showed that these resumed subgroup B viruses were closely related to the viruses detected in 2013 to 2016 in Yokohama and in 2019 in Fukushima, suggesting a reappearance of local endemic viruses in East Japan.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"76 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139062152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan 首次在日本关东地区的蜱虫中发现荆门蜱病毒

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.347

Ryo Matsumura, Daisuke Kobayashi, Kyo Itoyama, Haruhiko Isawa

{"title":"First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan","authors":"Ryo Matsumura, Daisuke Kobayashi, Kyo Itoyama, Haruhiko Isawa","doi":"10.7883/yoken.jjid.2023.347","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.347","url":null,"abstract":"In 2010, the Jingmen tick virus (JMTV) was discovered in ticks in China and has been shown to be distributed in several regions worldwide. Recently, cases of JMTV infection in humans have been reported in China and Kosovo, attracting much attention as an emerging tick-borne disease. In this study, we detected the JMTV genome in Amblyomma testudinarium ticks collected in Kanagawa Prefecture, Japan, during tick-borne virus surveillance conducted in the Kanto district. Phylogenetic analysis revealed that the new JMTV strain is closely related to previous strains detected in Japan. This suggests that JMTV may have been maintained during an independent natural transmission cycle in Japan. In addition, unlike in other countries and regions, all JMTV strains in Japan were detected only in A. testudinarium ticks, suggesting that this tick species is the primary JMTV vector in Japan. This report is the first to detect JMTV in the Kanto region. Further studies are required to elucidate the potential risk of infection by this tick-borne virus in Japan. In particular, the prevalence of JMTV in wild animals should be examined to clarify its geographical distribution, host range, and transmission cycle in nature.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"35 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139051135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myroides odoratimimus: a New Threat with Persistent Infections, Multidrug Resistance, and the Potential for Hospital Outbreaks. 多效密蝇:持续感染、多药耐药和可能在医院暴发的新威胁

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2023.005

Ismail Selcuk Aygar, Canset Nur Aydogan, Hande Ozcan, Irem Unat, Tugba Fatsa, Kemal Tekin, Aysun Yalci, Tugrul Hosbul, Fatih Sahiner, Ramazan Gumral

{"title":"Myroides odoratimimus: a New Threat with Persistent Infections, Multidrug Resistance, and the Potential for Hospital Outbreaks.","authors":"Ismail Selcuk Aygar, Canset Nur Aydogan, Hande Ozcan, Irem Unat, Tugba Fatsa, Kemal Tekin, Aysun Yalci, Tugrul Hosbul, Fatih Sahiner, Ramazan Gumral","doi":"10.7883/yoken.JJID.2023.005","DOIUrl":"10.7883/yoken.JJID.2023.005","url":null,"abstract":"Myroides species have recently been reported more frequently in outbreaks in clinics and intensive care units (ICUs). In this study, we aimed to investigate the epidemic potential, antibiotic resistance profile, and risk factors of M. odoratimimus isolates that are increasingly being isolated from the ICUs of our hospital. Data from patients whose Myroides spp. were isolated from their clinical specimens over a 5-year period (September 2016 to January 2022) were retrospectively analyzed. Bacterial identification was performed using a matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The presence of antibiotic resistance genes was analyzed using polymerase chain reaction (PCR). Possible clonal associations between isolates were investigated using enterobacterial repetitive intergenic consensus (ERIC)-PCR. As a result, 66 isolates were identified as M. odoratimimus and one isolate was identified as M. odoratus. The blaMUS resistance gene was detected in all M. odoratimimus isolates, whereas sul2 was detected in ten isolates and tetX was detected in 11 isolates. No other resistance genes, such as blaTUS, were detected. Additionally, two different clonal association patterns were discovered in the 24 selected isolates through the ERIC-PCR method. The increase in the immunosuppressive patient population indicate the possibility of encountering this agent and other opportunistic pathogens more frequently in the future.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"335-342"},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Did Financial Social Support for Tuberculosis Patients Lead to Better Treatment Outcomes in Türkiye during 2018-2019? 在2018-2019年期间，对结核病患者的经济社会支持是否会导致更好的治疗效果?

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.196

Selda Sahan, Seher Topluoglu, Fehminaz Temel, Mehmet Enes Gokler, Sedat Kaygusuz

{"title":"Did Financial Social Support for Tuberculosis Patients Lead to Better Treatment Outcomes in Türkiye during 2018-2019?","authors":"Selda Sahan, Seher Topluoglu, Fehminaz Temel, Mehmet Enes Gokler, Sedat Kaygusuz","doi":"10.7883/yoken.JJID.2023.196","DOIUrl":"10.7883/yoken.JJID.2023.196","url":null,"abstract":"This study examined which factors, including the regular financial social support program, influence tuberculosis (TB) treatment outcomes and success rates. Patients with TB registered during 2018-2019 were included in this retrospective cohort study. We classified them into 2 groups: those who received financial support for at least one month, and those who did not. Of the 22,867 sampled patients, 5,033 received financial social support and 17,834 did not. The success rate was 11.9% higher among patients who received financial social support than among those who did not (97.34% versus 85.40%). After controlling for other factors, the success rate among all patients was 1.3 times higher for female, 2.6 times higher for those under 50 years, 1.5 times higher for extra-pulmonary TB, 1.5 times higher for a new case, 5.9 times higher for drug susceptible TB, and 5.8 times higher for those who received financial support. Crucially, this is the first study from Türkiye evaluating the effect of a regular financial social support program on TB treatment outcomes since the program began in 2018. We recommend regular financial support for patients with TB in all countries.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"365-371"},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10494630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Participation in Rubella Antibody Testing among Working-Aged Men during Annual Health Check-Ups from 2019 to 2022 in Japan. 2019 - 2022年日本劳动年龄男性年度健康检查中风疹抗体检测参与趋势

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2022.614

Ai Hori, Bibha Dhungel, Satsue Nagahama

{"title":"Trends in Participation in Rubella Antibody Testing among Working-Aged Men during Annual Health Check-Ups from 2019 to 2022 in Japan.","authors":"Ai Hori, Bibha Dhungel, Satsue Nagahama","doi":"10.7883/yoken.JJID.2022.614","DOIUrl":"10.7883/yoken.JJID.2022.614","url":null,"abstract":"In 2019, the Japanese government established a scheme for rubella antibody testing of men born between 1962 and 1978 during workplace health check-ups. However, the use of vouchers for rubella antibody testing was limited. Health check-up data analyses are needed to determine the reason why rubella antibody testing is not widely used. In this study, we aimed to describe changes in rubella antibody test-taking behavior during health check-ups during the first 3 years of the rubella catch-up campaign in Japan. In 2019, 2020, and 2021 (2020 in some areas) vouchers were sent to men born during the fiscal years 1972-1978, 1966-1971, and 1962-1965, respectively. We calculated the prevalence in men born between 1962 and 1978 who underwent rubella antibody testing during mandatory health check-ups under the Industrial Health and Safety Act. Rubella antibody testing uptake was relatively high (approximately 15%) in all three age groups soon after the distribution of the vouchers and then declined to below 2% during the second and third years. Further population-based approaches with continuous public engagement are required in workplaces to effectively promote and expand the rubella vaccination program in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"372-375"},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism rs8177374 and Cytokine (IFN-γ, TNF-α, IL-10, TGF-β) Levels in Diverse Malaria Manifestations upon P. falciparum and P. vivax Infections. MyD88-Adaptor-Like (MAL)基因多态性rs8177374和细胞因子(IFN-γ、TNF-α、IL-10、TGF-β)水平在恶性疟原虫和间日疟原虫感染不同疟疾表现中的作用

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.079

Asima Rani, Syed Kashif Nawaz, Muhammad Arshad, Najma Arshad

{"title":"Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism rs8177374 and Cytokine (IFN-γ, TNF-α, IL-10, TGF-β) Levels in Diverse Malaria Manifestations upon P. falciparum and P. vivax Infections.","authors":"Asima Rani, Syed Kashif Nawaz, Muhammad Arshad, Najma Arshad","doi":"10.7883/yoken.JJID.2023.079","DOIUrl":"10.7883/yoken.JJID.2023.079","url":null,"abstract":"This study investigated the role of genetic variant rs8177374 in MAL/TIRAP gene in mediating the cytokine levels of IFN-γ, TNF-α, IL-10, and TGF-β in malaria patients due to Plasmodium falciparum or P. vivax infection. The study included human blood samples collected from patients with malaria (n = 228) and healthy controls (n = 226). P. falciparum and P. vivax groups were established based on the causative species of Plasmodium. Malaria samples were divided into mild and severe malaria groups based on the symptoms that appeared in the patients, according to the WHO criteria. In a previous study, we genotyped rs8177374 via allele specific PCR strategy. In this study, cytokine levels were estimated in the blood plasma of rs8177374 genotype samples via Sandwich Enzyme Linked Immunosorbent Assay kits. Increased IFN-γ and TNF-α levels in presence of CC genotype indicates the role of CC genotype in both severe and mild malaria groups. Enhanced IL-10 levels in the CT genotype and mild malaria groups suggest a role of CT genotype and IL-10 in the mild clinical outcomes of malaria. The rs8177374 polymorphism in MAL/TIRAP plays an important role in malaria pathogenesis.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"358-364"},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-to-Lymphocyte Ratio and the Systemic Immune-Inflammation Index: Biomarkers in Infants with Bronchiolitis: a Cross-Sectional Study. 中性粒细胞与淋巴细胞比率和全身免疫炎症指数:毛细支气管炎婴儿的生物标志物:一项横断面研究。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-07-31 DOI: 10.7883/yoken.JJID.2023.062

Özlem Erdede, Erdal Sarı, Nihan Uygur Külcü, Rabia Gönül Sezer Yamanel

{"title":"Neutrophil-to-Lymphocyte Ratio and the Systemic Immune-Inflammation Index: Biomarkers in Infants with Bronchiolitis: a Cross-Sectional Study.","authors":"Özlem Erdede, Erdal Sarı, Nihan Uygur Külcü, Rabia Gönül Sezer Yamanel","doi":"10.7883/yoken.JJID.2023.062","DOIUrl":"10.7883/yoken.JJID.2023.062","url":null,"abstract":"The use of a novel inflammatory indicator, the systemic immune-inflammatory index (SII), in pediatric patients with bronchiolitis remains unreported. Therefore, this study investigated the relationship between the SII and the neutrophil-to-lymphocyte ratio (NLR) in patients with respiratory syncytial virus (RSV) and non-RSV bronchiolitis and clinical severity prediction. This study analyzed the data of 155 patients aged <2 years who were hospitalized for viral bronchiolitis caused by RSV and/or other viral pathogens. The SII (platelet count × [neutrophil/lymphocyte]) was calculated and compared among patients with RSV mono-infections, other viral mono-infections, and RSV co-infections. Severity was defined by the number of days of supplemental oxygen treatment. The NLR and SII were significantly higher in the non-RSV mono-infection group than in the RSV mono-infection group, and the number of days of supplemental oxygen therapy was significantly higher in the RSV mono-infection group. No significant differences in the NLR, SII, or days of supplemental oxygen therapy were found between the RSV mono-infection and RSV co-infection groups. Although patients with RSV mono-infection showed more severe clinical findings than those without non-RSV mono-infection, the NLR and SII values were significantly higher in the non-RSV mono-infection group. Therefore, the NLR and SII do not appear to be very useful measurements for determining the severity of acute bronchiolitis attacks; however, lower NLR and SII values in the RSV group compared to the non-RSV group may be potential biomarkers for RSV infection. Therefore, further studies are warranted.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"351-357"},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9899814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge about Hepatitis E and Influencing Factors among Residents in Qingdao: a Cross-Sectional Study. 青岛市居民戊型肝炎知识及其影响因素的横断面研究

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2023.144

Wenliang Fei, Wencheng Wang, Xiaofan Li, Sicheng Hao, Feng Yang

引用次数: 0

Enterovirus Meningitis without Pleocytosis: a Retrospective Observational Study in Adults. 无多胞症的肠病毒性脑膜炎:一项成人回顾性观察研究。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2023.123

Dongkeun Roh, Woochan Jeon, Jisook Lee

{"title":"Enterovirus Meningitis without Pleocytosis: a Retrospective Observational Study in Adults.","authors":"Dongkeun Roh, Woochan Jeon, Jisook Lee","doi":"10.7883/yoken.JJID.2023.123","DOIUrl":"10.7883/yoken.JJID.2023.123","url":null,"abstract":"Reverse-transcription polymerase chain reaction (RT-PCR)-confirmed enterovirus (EV) meningitis without pleocytosis has only been previously reported in children. In this study, we examined the frequency of EV meningitis without pleocytosis in adults and compared its clinical features. We retrospectively analyzed the data of adult patients with EV meningitis confirmed using cerebrospinal fluid (CSF) RT-PCR. Among the 17 patients included in this study, 58.8% showed no pleocytosis. The median age and clinical symptoms did not differ between the pleocytosis and non-pleocytosis groups. There were no statistically significant differences in seasonal variation or time from the onset of meningitis symptoms to lumbar puncture. The peripheral white blood cell (WBC) count in patients with pleocytosis was significantly higher than that in patients without pleocytosis. The median CSF pressure showed a higher trend in the non-pleocytosis group. Patients with CSF pressures higher than normal were more common in the non-pleocytosis group. The median CSF protein values were higher than the normal values in both groups. We confirmed the high frequency of EV meningitis without pleocytosis in adults. Accurate diagnosis using RT-PCR is necessary when meningitis symptoms are prominent during an EV epidemic, and CSF protein levels and pressure are high, even if the CSF WBC count is normal.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"329-334"},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0