Japanese journal of infectious diseases最新文献_第10页

Immunogenicity and Safety of a Quadrivalent Meningococcal Tetanus Toxoid-Conjugate Vaccine (MenACYW-TT) in Meningococcal Vaccine-Naïve Participants across a Broad Age Range (2-55 Years) in Japan: a Phase III Randomized Study. 四价脑膜炎球菌-破伤风类毒素结合疫苗(MenACYW-TT)在日本广泛年龄范围(2-55岁)脑膜炎球菌Vaccine-Naïve参与者中的免疫原性和安全性:一项III期随机研究

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.272

Osamu Matsuoka, Mugen Ujiie, Hitoshi Kikuchi, Sachiko Otake, Danaya Chansinghakul, Takahiro Inoue, Kucku Varghese, Nuchra Sirisuphmitr, Tomoyuki Hashiguchi, Betzana Zambrano, Takahiro Nakama, Carina Frago, Emilia Jordanov, Mandeep Singh Dhingra

{"title":"Immunogenicity and Safety of a Quadrivalent Meningococcal Tetanus Toxoid-Conjugate Vaccine (MenACYW-TT) in Meningococcal Vaccine-Naïve Participants across a Broad Age Range (2-55 Years) in Japan: a Phase III Randomized Study.","authors":"Osamu Matsuoka, Mugen Ujiie, Hitoshi Kikuchi, Sachiko Otake, Danaya Chansinghakul, Takahiro Inoue, Kucku Varghese, Nuchra Sirisuphmitr, Tomoyuki Hashiguchi, Betzana Zambrano, Takahiro Nakama, Carina Frago, Emilia Jordanov, Mandeep Singh Dhingra","doi":"10.7883/yoken.JJID.2022.272","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.272","url":null,"abstract":"MenACYW-TT is a quadrivalent meningococcal tetanus toxoid-conjugate vaccine designed to prevent invasive meningococcal disease. The primary objective of this study was to demonstrate non-inferiority of the vaccine seroresponse to a single dose of MenACYW-TT compared with MCV4-DT, a licensed meningococcal quadrivalent diphtheria-conjugate vaccine. This Phase III double-blind, multicenter trial was conducted in meningococcal vaccine-naïve individuals aged 2-55 years in Japan (NCT04368429; jRCT2080225192). Participants were randomized 1:1 to receive either MenACYW-TT (n = 180) or MCV4-DT (n = 180). Functional antibodies against meningococcal serogroups A, C, W, and Y were measured using a serum bactericidal antibody assay with human complement (hSBA) at baseline (D0) and 30 days after vaccination (D30). Seroresponse was defined as a post-vaccination titer ≥1:16 in participants with a baseline titer <1:8; or a ≥4-fold increase in titer in participants with a baseline titer ≥1:8. Safety data were collected for 30 days. Non-inferiority of the seroresponse to MenACYW-TT vs. MCV4-DT was demonstrated on D30 for each serogroup tested (A: 85.6% vs. 65.4%; C: 96.6% vs. 62.6%; W: 87.4% vs. 49.2%; Y: 97.7% vs. 63.5%). MenACYW-TT was well tolerated with no safety concerns identified. A single dose of MenACYW-TT was well tolerated, with a non-inferior seroresponse compared with MCV4-DT. MenACYW-TT could thus be used as an alternative vaccine in meningococcal vaccine-naïve individuals.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ubiquitin-Specific Peptidase 8 Is Critical for the Onset of Infectious Osteomyelitis by Targeting RIPK2 Ubiquitination. 泛素特异性肽酶8通过靶向RIPK2泛素化对感染性骨髓炎的发病至关重要。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.515

Yuanliang Chen, Yongbai Wan, Haojie Shan, Yiwei Lin, Wenyang Xia, Fuli Yin, Chaolai Jiang, Zhongmin Shi

{"title":"Ubiquitin-Specific Peptidase 8 Is Critical for the Onset of Infectious Osteomyelitis by Targeting RIPK2 Ubiquitination.","authors":"Yuanliang Chen, Yongbai Wan, Haojie Shan, Yiwei Lin, Wenyang Xia, Fuli Yin, Chaolai Jiang, Zhongmin Shi","doi":"10.7883/yoken.JJID.2022.515","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.515","url":null,"abstract":"Receptor-interacting serine/threonine kinase (RIPK) is associated with cellular inflammation and immune regulation. The current study explored the role of RIPK2 in osteomyelitis and the potential upstream targets of RIPK2. A Staphylococcus aureus-induced osteomyelitis mouse model was established using wild-type (WT) and ubiquitin-specific peptidase 8 (USP8)-deficient (USP-/-) mice, and the osteomyelitis-related symptoms were evaluated. Bone marrow-derived macrophages (BMDMs) were isolated from the WT and USP-/- mice. Enzyme-linked immunosorbent assays, quantitative polymerase chain reaction, and immunoblot analysis were used to determine the levels of target biomarkers, which were induced by lipopolysaccharide (LPS), CpG, or PAM3CSK4. USP8 promoted RIPK2-mediated NF-κB activation. USP8 is indispensable for RIPK2-mediated LPS-induced NF-κB activation in BMDMs. USP8 is required for the production of inflammatory cytokines induced by LPS, CpG, or PAM3CSK4 in BMDMs. In addition, USP-/- mice exhibited ameliorated symptoms, including less body weight and cortical bone loss, and reduced bacterial load and reactive bone formation in the S. aureus-induced osteomyelitis mouse model. USP8 is critical in the S. aureus-induced osteomyelitis mouse model by targeting RIPK2 ubiquitination.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9520228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Spread of Heat-Labile Enterotoxin-Harboring Escherichia fergusonii in Broiler Chickens and Pigs in Okinawa, Japan. 日本冲绳肉鸡和猪中携带热不稳定肠毒素的弗格森埃希菌的传播。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.625

Tetsuya Kakita, Tsuyoshi Kudeken, Haruno Taira, Sho Okano, Hisako Kyan, Makoto Ohnishi

{"title":"The Spread of Heat-Labile Enterotoxin-Harboring Escherichia fergusonii in Broiler Chickens and Pigs in Okinawa, Japan.","authors":"Tetsuya Kakita, Tsuyoshi Kudeken, Haruno Taira, Sho Okano, Hisako Kyan, Makoto Ohnishi","doi":"10.7883/yoken.JJID.2022.625","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.625","url":null,"abstract":"In 2012, Escherichia fergusonii harboring a heat-labile enterotoxin (LT) was isolated from healthy chickens in South Korea. However, little is known regarding the prevalence, spread, and pathogenicity of these strains in humans and animals. This study aimed to understand the public health threats, such as the distribution, antimicrobial resistance, and genetic diversity of E. fergusonii carrying LTs. E. fergusonii containing LT was isolated from 15.0% (52/346) of chicken fecal samples from all three tested chicken farms but not from 360 pig fecal samples. The antimicrobial susceptibility testing revealed that over 75% of strains were resistant to ampicillin, kanamycin, nalidixic acid, streptomycin, or tetracycline; additionally, 71.2% (37/52) of strains were resistant to all five of these antimicrobials. The 52 strains were clustered into eight pulsed-field gel electrophoresis (PFGE) types, with types V and type VI accounting for 84.6% (44/52). In the present study, multiple chicken farms harbored E. fergusonii with similar antimicrobial resistance patterns and genetic clonality. Since the pathogenicity of LT-bearing E. fergusonii in humans and animals, such as food poisoning and sporadic diarrhea via meat, the transmission of the strains, and the dissemination of antimicrobial resistance genes are unknown, additional research is required.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Active Case Finding Using Mobile Chest Radiography among Homeless People with Pulmonary Tuberculosis in Osaka City, Japan, 2013-2019. 2013-2019年日本大阪市无家可归肺结核患者移动胸片主动病例发现

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.623

Jun Komukai, Kenji Matsumoto

{"title":"Active Case Finding Using Mobile Chest Radiography among Homeless People with Pulmonary Tuberculosis in Osaka City, Japan, 2013-2019.","authors":"Jun Komukai, Kenji Matsumoto","doi":"10.7883/yoken.JJID.2022.623","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.623","url":null,"abstract":"Mobile digital chest radiography (CR) is a commonly used method for pulmonary tuberculosis (PTB) screening among homeless people in Nishinari District, Osaka City, Japan. We investigated mobile CR screening (MCS) to calculate the case-finding rate of culture-confirmed PTB among homeless examinees in Nishinari District from 2013 to 2019. PTB was defined as a sputum culture-confirmed case. Examinees with culture-confirmed PTB >90 days after MCS were defined as having no progression to active tuberculosis when undergoing MCS. We collected participants' information, including their name, date of birth, age, sex, date of MCS, CR classification (whether the abnormal CR result required further investigation), date of PTB diagnosis, and sputum smear results. Of 10,111 homeless people, 175 (1.7%) with abnormal CR results underwent further investigation at medical facilities. Of those with abnormal CR results, 22 (0.22%) were diagnosed with culture-positive PTB within 90 days of MCS. Of 22 PTB cases with culture-positive results, 13 (59.1%) were smear-positive. We found that MCS contributed to the detection of PTBs with a lower smear-positive rate among patients with PTB analyzed by MCS compared with all culture-confirmed PTB cases in Nishinari District.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Confirmation of an Indole-Negative Klebsiella oxytoca Isolated from a Patient with Cystitis. 从膀胱炎患者分离出一株吲哚阴性催产克雷伯菌的分子证实。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-03-24 DOI: 10.7883/yoken.JJID.2022.575

Youta Takano, Makiko Shibano, Yuuya Takizawa, Eriko Arai, Shinobu Koyama, Takahiro Shimizu, Takehisa Matsumoto

{"title":"Molecular Confirmation of an Indole-Negative Klebsiella oxytoca Isolated from a Patient with Cystitis.","authors":"Youta Takano, Makiko Shibano, Yuuya Takizawa, Eriko Arai, Shinobu Koyama, Takahiro Shimizu, Takehisa Matsumoto","doi":"10.7883/yoken.JJID.2022.575","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.575","url":null,"abstract":"Klebsiella oxytoca is an opportunistic pathogen that causes nosocomial infections. Here, we describe an unusual clinical strain of indole-negative K. oxytoca, GU175, isolated from the urine of a patient with cystitis. The GU175 strain was identified as K. pneumoniae with a probability of 99.40%, negative for indole production, and resistant to third-generation cephalosporins by using the MicroScan Walkaway 40 SI system with the Negative combo EN1 J panel. Biochemical characterization of this strain using lysine-indole motility medium was negative for indole production. However, identification tests using the MALDI Biotyper system and 16S rRNA gene sequence analysis revealed that GU175 is K. oxytoca. DNA sequence analysis of the tryptophanase operon comparing the GU175 strain with the revertant GU176 strain, which tested positive for indole, revealed a point mutation in the Shine-Dalgarno sequence upstream of tnaC in the GU175 strain. This is the first report of indole-negative K. oxytoca, which was attributed to a mutation in the DNA sequence of the tryptophanase operon isolated from a patient with a urinary tract infection. As indole-negative K. oxytoca can be misidentified as K. pneumoniae by biochemical characterization, clinical microbiologists should be aware of such misidentifications.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9182760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Epidemiology of Penicillinase-Producing Neisseria gonorrhoeae Isolates and Their bla_TEM-135 Gene Variant in Bangkok, Thailand, 2015-2017. 泰国曼谷产青霉素酶淋病奈瑟菌分离株及其blatem135基因变异的分子流行病学研究

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-03-24 DOI: 10.7883/yoken.JJID.2022.484

Natakorn Nokchan, Perapon Nitayanon, Chanwit Tribuddharat

{"title":"Molecular Epidemiology of Penicillinase-Producing Neisseria gonorrhoeae Isolates and Their blaTEM-135 Gene Variant in Bangkok, Thailand, 2015-2017.","authors":"Natakorn Nokchan, Perapon Nitayanon, Chanwit Tribuddharat","doi":"10.7883/yoken.JJID.2022.484","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.484","url":null,"abstract":"Penicillinase-producing Neisseria gonorrhoeae (PPNG) possessing blaTEM-135 is a serious public health threat. With only a single change in the amino acid sequence, blaTEM-135 could evolve into a TEM-type extended-spectrum beta-lactamase (ESBL), which hydrolyzes extended-spectrum cephalosporins, including ceftriaxone and cefixime. We investigated the molecular epidemiological characteristics, types of plasmids in PPNG isolates, and prevalence of PPNG clinical isolates producing TEM-135 beta-lactamases. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was used to determine the molecular epidemiological characteristics of 99 PPNG isolates collected from 2015 to 2017. A mismatch amplification mutation assay was used to examine the blaTEM-135 gene prevalence. Of the 89 identified NG-MAST sequence types, 65 (73.0%) were novel. Only 17.7% (43/243) of PPNG isolates belonged to 16 genogroups. The most frequent plasmid was African, followed by Rio/Toronto, and Asian. The blaTEM-135 allele was found in Rio/Toronto plasmids. The blaTEM-135 allele was present in 23.2% (23/99) of the PPNG isolates. PPNG isolates expressing TEM-135 beta-lactamase exhibited significantly higher penicillin MIC (minimum inhibitory concentration) values than TEM-1 PPNG isolates. The PPNG isolates showed high genetic diversity and a high proportion of blaTEM-135 alleles. Mutation of the blaTEM-135 allele is worrisome as only one mutation could cause TEM-1 to evolve into an ESBL variant that degrades ceftriaxone. Ongoing surveillance of blaTEM-135 and new PPNG isolates is imperative.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9183435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofilm Production Ability of Streptococcus dysgalactiae Subsp. equisimilis: Associations with Host Species, Lancefield Group, Source, Clonal Complex, and Virulence-Associated Genes. 乳酸不良链球菌亚种的生物膜生成能力。同宿主物种、Lancefield类群、来源、克隆复合体和毒力相关基因的关联。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-03-24 DOI: 10.7883/yoken.JJID.2022.579

Takahiro Maeda, Yoshiko Takayama, Mieko Goto, Haruno Yoshida, Tomohiro Fujita, Yuzo Tsuyuki, Takashi Takahashi

{"title":"Biofilm Production Ability of Streptococcus dysgalactiae Subsp. equisimilis: Associations with Host Species, Lancefield Group, Source, Clonal Complex, and Virulence-Associated Genes.","authors":"Takahiro Maeda, Yoshiko Takayama, Mieko Goto, Haruno Yoshida, Tomohiro Fujita, Yuzo Tsuyuki, Takashi Takahashi","doi":"10.7883/yoken.JJID.2022.579","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.579","url":null,"abstract":"We assessed the biofilm production ability (BPA) of noninvasive Streptococcus dysgalactiae subsp. equisimilis (SDSE) in humans and companion animals and determined the relationship between bacterial populations with BPA and other host and microbiological features. Sixty-four isolates from companion animals and humans were collected along with host information. We measured BPA using crystal violet staining, in addition to emm typing, multilocus sequence typing, antimicrobial resistance (AMR) phenotyping/genotyping, and virulence-associated gene (VAG) detecting (prtF1-prtF2-lmb-cbp-sicG-srtp1-srtp2-brpA). Differences in the BPA of SDSE from different hosts and sources and different Lancefield groups were assessed. We analyzed the associations between populations with and without BPA (strong, moderate, weak, and no biofilm producers) and emm types, sequence types/clonal complexes (CCs), AMR phenotypes/genotypes, and VAG types. Seventeen, twenty-four, and twelve isolates were strong, moderate, and weak biofilm producers, respectively; eleven showed no BPA. There was a difference in the distribution of populations with BPA between human and animal origins and between isolates of groups G and C. We found an association between populations with BPA and the eye and ear source (vs. the pus and skin source). A relationship was observed between the populations with BPA and CC127 (vs. CC17). We observed no association between the populations with BPA and AMR phenotype/genotype. There was an association between the distribution of populations with BPA and srtp1 expression. Our observations suggest potential associations between populations with BPA and the host species, Lancefield group, source, CC, and VAG type.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9183439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Workflow for Identification of Burkholderia pseudomallei Clinical Isolates in Myanmar. 缅甸假马尔氏伯克氏菌临床分离株鉴定工作流程

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-03-24 DOI: 10.7883/yoken.JJID.2022.508

Nay Myo Aung, Khine Khine Su, Narisara Chantratita, Chanwit Tribuddharat

{"title":"Workflow for Identification of Burkholderia pseudomallei Clinical Isolates in Myanmar.","authors":"Nay Myo Aung, Khine Khine Su, Narisara Chantratita, Chanwit Tribuddharat","doi":"10.7883/yoken.JJID.2022.508","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.508","url":null,"abstract":"Burkholderia pseudomallei, the highly infectious and causative organism of melioidosis, was first identified in Myanmar in 1911. B. pseudomallei was identified in Myanmar because of its genetic relatedness to Burkholderia species. In this study, we identified two isolates of Burkholderia cenocepacia, two Acinetobacter baumannii complexes, and 18 clinical isolates of B. pseudomallei using Vitek 2. These isolates were first screened using a latex agglutination test, which showed positive results in 20 of the 22 isolates. All isolates were cultured on Ashdown՚s agar and further tested using molecular methods. Specific PCR for type III secretion system (TTSs) gene clusters indicated 19 B. pseudomallei isolates out of 22 isolates. Furthermore, 16S rRNA and recA gene sequencing were used as the gold standard methods and yielded the same results. RapID NF Plus detected 16 B. pseudomallei out of 22 isolates. Vitek 2 and RapID NF Plus should be considered key tools in the diagnosis of melioidosis and surveillance of B. pseudomallei in Myanmar; however, accurate identification must be confirmed by TTS1 PCR. This study evaluated the presumptive workflow for the investigation of B. pseudomallei infections using different methods and options, in line with the available equipment.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9183433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Novel Positive Pressure Protective Suit for a Biosafety Level 4 Laboratory in Japan. 日本生物安全四级实验室新型正压防护服的研制。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-03-24 DOI: 10.7883/yoken.JJID.2022.475

Shintaro Shichinohe, Yasuteru Sakurai, Daisuke Hayasaka, Eri Yamada, Katsuaki Shinohara, Yohei Kurosaki, Kensuke Nakajima

{"title":"Development of a Novel Positive Pressure Protective Suit for a Biosafety Level 4 Laboratory in Japan.","authors":"Shintaro Shichinohe, Yasuteru Sakurai, Daisuke Hayasaka, Eri Yamada, Katsuaki Shinohara, Yohei Kurosaki, Kensuke Nakajima","doi":"10.7883/yoken.JJID.2022.475","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.475","url":null,"abstract":"Biosafety level 4 (BSL-4) laboratories are necessary to study microorganisms that are highly pathogenic to humans and have no prevention or therapeutic measures. Currently, most BSL-4 facilities have suit-type laboratories to conduct experiments on highly pathogenic microorganisms. In 2021, the first Japanese suit-type BSL-4 laboratory was constructed at Nagasaki University. Positive pressure protection suit (PPPS) is a primary barrier that protects and isolates laboratory workers from pathogens and the laboratory environment. Here, we developed a novel PPPS originally designed to be used in the Nagasaki BSL-4 laboratory. We modified several parts of a domestic chemical protective suit, including its front face shield, cuff, and air supply hose, for safe handling of microbiological agents. The improved suit, PS-790BSL4-AL, showed resistance to several chemicals, including quaternary ammonium disinfectant, and did not show any permeation against blood and phages. To validate the suit's integrity, we also established an airtight test that eliminated individual differences for quantitative testing. In conclusion, our developed suit performs sufficiently as a primary barrier and allows for the safe handling of pathogens in our new BSL-4 laboratory.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9182756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertical Transmission Rate of Human Immunodeficiency Virus Exposed Twin Pregnancies and Associated Factors in West Bengal, India: a Retrospective Cohort Study. 印度西孟加拉邦暴露于人类免疫缺陷病毒的双胎妊娠垂直传播率及其相关因素:一项回顾性队列研究

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-03-24 DOI: 10.7883/yoken.JJID.2022.562

Suman Ganguly, Debjit Chakraborty, Sitikantha Banerjee, Falguni Debnath, Subrata Biswas, Agniva Majumdar, Shanta Dutta

{"title":"Vertical Transmission Rate of Human Immunodeficiency Virus Exposed Twin Pregnancies and Associated Factors in West Bengal, India: a Retrospective Cohort Study.","authors":"Suman Ganguly, Debjit Chakraborty, Sitikantha Banerjee, Falguni Debnath, Subrata Biswas, Agniva Majumdar, Shanta Dutta","doi":"10.7883/yoken.JJID.2022.562","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.562","url":null,"abstract":"Twin pregnancies are often associated with adverse obstetric outcomes. The mother-to-child transmission of the human immunodeficiency virus (HIV) in twin pregnancies has been less explored. Therefore, the present study aimed to determine the risk of vertical transmission of HIV in HIV-exposed twin pregnancies compared with that of singleton pregnancies and to explore the associated factors. We conducted a retrospective cohort study involving 348 HIV-exposed babies (58 twins and 290 singletons) through a systematic sampling from the program database of West Bengal, India, from April 2016 to March 2021. HIV vertical transmission rates were compared between single and twin live births. The effects of factors such as maternal age, timing of maternal HIV diagnosis, duration of antiretroviral treatment, mode of delivery, birth weight, and the sex of the baby were determined. The HIV transmission rate for twin pregnancies (15.5%) was significantly higher than that for single live births (5.5%) (adjusted odds ratio [OR] = 3.38 [1.17-9.69]). Among twin deliveries, maternal HIV diagnosis during the intrapartum and postpartum period was associated with HIV transmission (crude OR = 11.0, [2.2-54.9]). Perinatal HIV transmission is more common in twin pregnancies and is associated with the time of detection of maternal HIV. Therefore, early HIV detection and additional antiretroviral regimens should be considered for twin pregnancies.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9182757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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