日本岛根县下越型恙虫病的传播周期。

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI:10.7883/yoken.JJID.2023.137
Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara
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引用次数: 0

摘要

为了证明下越型恙虫病在岛根县的传播周期,研究人员从报道过四例该病原体引起的人类感染病例的地区捕获了野外啮齿类动物。根据病原体基因组、病原体抗体和病原体载体(Leptotrombidium palpale),对啮齿类动物进行了病原体传播周期调查。此外,还从研究区域的土壤中捕获了病媒。总共捕获了 44 只啮齿动物。通过实时聚合酶链式反应,在血液或脾脏样本中未检测到恙虫卵 DNA。不过,用间接免疫过氧化物酶法在 44 只啮齿类动物中的 2 只(4.5%)检测到了该病原体的特异性抗体,表明研究区域存在该病原体。虽然鉴定出了 29 只 L. palpale,但根据以往研究的 DNA 检测率,由于载体数量不足,因此没有进行 DNA 检测。然而,病媒的鉴定以及啮齿动物体内的特异性抗体表明岛根县存在下越型恙虫病的传播周期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transmission Cycle of Shimokoshi-Type Orientia tsutsugamushi in Shimane Prefecture, Japan.

To demonstrate the transmission cycle of Shimokoshi-type Orientia tsutsugamushi in Shimane Prefecture, field rodents were captured from areas where four human infections caused by the pathogen have been reported. The rodents were investigated for the transmission cycle of the pathogen based on the pathogen's genome, antibodies against the pathogen, and the vector of the pathogen (Leptotrombidium palpale). In addition, the vector was captured from the soil in the study area. A total of 44 rodents were captured. No O. tsutsugamushi DNA was detected in the blood or spleen samples by real-time polymerase chain reaction. However, a specific antibody against the pathogen was detected in 2 out of 44 (4.5%) rodents using the indirect immunoperoxidase method, indicating the presence of the pathogen in the study area. Although 29 L. palpale were identified, DNA detection was not performed because of the insufficient number of vectors, based on the DNA detection rate in previous studies. However, the identification of the vector, as well as the specific antibody in rodents, suggests the presence of the transmission cycle of Shimokoshi-type O. tsutsugamushi in Shimane Prefecture.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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