Japanese journal of infectious diseases最新文献_第9页

A Nosocomial Outbreak Caused by Human Rhinovirus Species A Type 61 in a Welfare Facility in Gunma Prefecture, Japan. 日本群马县一家福利院发生由甲型61型人鼻病毒引起的院内暴发。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 DOI: 10.7883/yoken.JJID.2023.039

Ryo Shimada, Hiroyuki Tsukagoshi, Rina Kubota, Daisuke Shinoda, Yuri Shinohara, Akio Saito, Fumitaka Inoue, Tadaaki Endo, Nobuhiro Saruki

引用次数: 0

Distribution of Human Sapovirus Strain Genotypes over the Last Four Decades in Japan: a Global Perspective. 人类萨波病毒株基因型在日本过去四十年的分布:全球视角。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 DOI: 10.7883/yoken.JJID.2022.704

Yen Hai Doan, Yasutaka Yamashita, Hiroto Shinomiya, Takumi Motoya, Naomi Sakon, Rieko Suzuki, Hideaki Shimizu, Naoki Shigemoto, Seiya Harada, Shunsuke Yahiro, Kyoko Tomioka, Akie Sakagami, Yo Ueki, Rika Komagome, Kyohei Saka, Reiko Okamoto-Nakagawa, Komei Shirabe, Fuminori Mizukoshi, Yono Arita, Kei Haga, Kazuhiko Katayama, Hirokazu Kimura, Masamichi Muramatsu, Tomoichiro Oka

{"title":"Distribution of Human Sapovirus Strain Genotypes over the Last Four Decades in Japan: a Global Perspective.","authors":"Yen Hai Doan, Yasutaka Yamashita, Hiroto Shinomiya, Takumi Motoya, Naomi Sakon, Rieko Suzuki, Hideaki Shimizu, Naoki Shigemoto, Seiya Harada, Shunsuke Yahiro, Kyoko Tomioka, Akie Sakagami, Yo Ueki, Rika Komagome, Kyohei Saka, Reiko Okamoto-Nakagawa, Komei Shirabe, Fuminori Mizukoshi, Yono Arita, Kei Haga, Kazuhiko Katayama, Hirokazu Kimura, Masamichi Muramatsu, Tomoichiro Oka","doi":"10.7883/yoken.JJID.2022.704","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.704","url":null,"abstract":"Sapovirus (SaV) infections are a public health problem because they cause acute gastroenteritis in humans of all ages, both sporadically and as outbreaks. However, only a limited amount of SaV sequence information, especially whole-genome sequences for all the SaV genotypes, is publicly available. Therefore, in this study, we determined the full/near-full-length genomic sequences of 138 SaVs from the 2001 to 2015 seasons in 13 prefectures across Japan. The genogroup GI was predominant (67%, n = 92), followed by genogroups GII (18%, n = 25), GIV (9%, n = 12), and GV (6%, n = 9). Within the GI genogroup, four different genotypes were identified: GI.1 (n = 44), GI.2 (n = 40), GI.3 (n = 7), and GI.5 (n = 1). We then compared these Japanese SaV sequences with 3,119 publicly available human SaV sequences collected from 49 countries over the last 46 years. The results indicated that GI.1, and GI.2 have been the predominant genotypes in Japan, as well as in other countries, over at least four decades. The 138 newly determined Japanese SaV sequences together with the currently available SaV sequences, could facilitate a better understanding of the evolutionary patterns of SaV genotypes.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9851472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prevalence of Sapovirus and Astrovirus in Pediatric Infectious Gastroenteritis Surveillance in Kobe City, Japan, 2016-2019. 神户市2016-2019年儿童感染性胃肠炎病毒和星状病毒流行监测

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 DOI: 10.7883/yoken.JJID.2023.037

Takeshi Hanafusa, Kentaro Arikawa, Yoshihiko Tanimoto

引用次数: 0

The Ubiquitination of RIPK2 is Mediated by Peli3 and Negatively Regulates the Onset of Infectious Osteomyelitis. RIPK2的泛素化是由Peli3介导的，并负向调控感染性骨髓炎的发生。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 DOI: 10.7883/yoken.JJID.2022.622

Lixiang Le, Haojie Shan, Yiwei Lin, Wenyang Xia, Xin Ma, Chaolai Jiang, Zhongmin Shi, Youjia Xu

{"title":"The Ubiquitination of RIPK2 is Mediated by Peli3 and Negatively Regulates the Onset of Infectious Osteomyelitis.","authors":"Lixiang Le, Haojie Shan, Yiwei Lin, Wenyang Xia, Xin Ma, Chaolai Jiang, Zhongmin Shi, Youjia Xu","doi":"10.7883/yoken.JJID.2022.622","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.622","url":null,"abstract":"Osteomyelitis is the infection and destruction of the bone. To date, there is no universal protocol for its treatment. Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) has been implicated in osteomyelitis development. However, the detailed mechanism remains unknown. Here, 6-8w wild-type or Pellino E3 Ubiquitin Protein Ligase Family Member 3 (Peli3)-deficient mice were injected with Staphylococcus aureus to induce osteomyelitis. RAW264.7 cells or bone marrow-derived macrophages isolated from mice were treated with lipopolysaccharide (LPS). Knocking down Peli3 in RAW264.7 cells increased the expression of inflammatory cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor-α) after LPS stimulation. Inflammation was also activated in S. aureus-induced Peli3-deficient mice. Moreover, S. aureus-infected Peli3-deficient mice also displayed more severe symptoms of osteomyelitis than S. aureus-infected wild-type mice. Moreover, Peli3 targets and degrades RIPK2 through K48-linked ubiquitination, and negatively modulates osteomyelitis by degrading RIPK2. Our data further expands the current understanding of RIPK2 in osteomyelitis, and suggests that RIPK2 might serve as a novel therapeutic target for treating osteomyelitis.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Viral Load and Host Cytokines in Determining the Disease Severity of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infections in Children. 病毒载量和宿主细胞因子在确定儿童呼吸道合胞病毒相关急性下呼吸道感染疾病严重程度中的作用

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-07-24 DOI: 10.7883/yoken.JJID.2022.673

Subhabrata Sarkar, Radha Kanta Ratho, Meenu Singh, Mini Pritam Singh, Amarjeet Singh, Megha Sharma

{"title":"Role of Viral Load and Host Cytokines in Determining the Disease Severity of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infections in Children.","authors":"Subhabrata Sarkar, Radha Kanta Ratho, Meenu Singh, Mini Pritam Singh, Amarjeet Singh, Megha Sharma","doi":"10.7883/yoken.JJID.2022.673","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.673","url":null,"abstract":"Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections (ALRTIs). In this study, we aimed to evaluate the role of viral load, cytokines, matrix metalloproteinase 9 (MMP-9), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in determining the severity of RSV disease and identify potential biomarkers of disease severity. A total of 142 patients with RSV infection (aged between 2 months and 5 years) who presented with ALRTI between December 2013 and March 2016 were enrolled. Their nasopharyngeal aspirates were subjected to RSV viral load quantification, and local cytokine levels of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), IL-17A, interferon γ (IFN-γ), and IL-10 were determined using a cytokine bead array. The levels of MMP-9 and TIMP-1 in 109 aspirates were calculated using Quantikine ELISA. These parameters were compared for different disease severity categories. A higher viral load and increased levels of TNF-α, MMP-9, and MMP-9:TIMP-1 were associated with greater severity of disease; whereas levels of IL-17A, IFN-γ, and IFN-γ:IL-10 were associated with disease resolution. When defining the transition from non-severe to severe disease, MMP-9 had a sensitivity and specificity of 89.7% and 85.4%, respectively. Moreover, MMP-9:TIMP-1 had a sensitivity and specificity of 87.2% and 76.8%, respectively. Hence, MMP-9, MMP-9:TIMP-1, TNF-α, and IL-10 could serve as potential biomarkers for disease progression in RSV-infected children.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends of Mismatches in Real-Time RT-PCR Assays Developed by the National Institute of Infectious Diseases, Japan for Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2. 日本国立传染病研究所开发的严重急性呼吸综合征冠状病毒组粒变异实时RT-PCR检测方法的错配趋势

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.556

Kazuya Shirato, Makoto Ujike, Miyuki Kawase

引用次数: 0

Surveillance of the Antimicrobial Susceptibility and Molecular Characteristics of Neisseria gonorrhoeae Isolates Collected in Changsha, China from 2016 to 2021. 2016 - 2021年长沙市淋病奈瑟菌分离株药敏及分子特征监测

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.532

Qianqin Yuan, Shiya Shi, Yufeng Dai, Mengjie Jiang, Ping Jiang, Danning Xu, Qinglin Liu, Chuanhao Jiang, Xinwu Guo, Hongzhi Chen, Lingli Tang

{"title":"Surveillance of the Antimicrobial Susceptibility and Molecular Characteristics of Neisseria gonorrhoeae Isolates Collected in Changsha, China from 2016 to 2021.","authors":"Qianqin Yuan, Shiya Shi, Yufeng Dai, Mengjie Jiang, Ping Jiang, Danning Xu, Qinglin Liu, Chuanhao Jiang, Xinwu Guo, Hongzhi Chen, Lingli Tang","doi":"10.7883/yoken.JJID.2022.532","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.532","url":null,"abstract":"Antibiotic treatment is critical for individuals infected with gonorrhea and preventing disease transmission. This study aimed to analyze the antimicrobial susceptibility and molecular epidemiological characteristics of Neisseria gonorrhoeae isolates in Changsha, China. A total of 271 N.gonorrhoeae isolates collected from the clinical laboratories of two hospitals between 2016 and 2021 were analyzed for antimicrobial susceptibility using the agar dilution method. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was conducted for genotyping, and phylogenetic analysis was performed using the porB and tbpB sequences. The results showed that antimicrobial resistance against ciprofloxacin, tetracycline, and penicillin was high, and these drugs are no longer recommended for the treatment of gonorrhea. All isolates were susceptible to spectinomycin. However, in 2016-2021, a total of 15 (5.5%) ceftriaxone (CRO)-resistant strains and 31 (11.4%) isolates with decreased susceptibility to CRO were found, and the resistance rate to azithromycin had reached 7.1% in 2016-2017. Epidemiologically, the mosaic penA allele was identified in all CRO-resistant isolates. Based on NG-MAST, ST5061 was the most prevalent ST. Phylogenetic analysis suggested that the resistant isolates did not cluster independently. Despite focus on the local situation, this study raises the need for better gonorrhea medication and highlights that CRO may not be adequate as first-line treatment for gonorrhea in Changsha.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Possible Transmission of Severe Fever with the Thrombocytopenia Syndrome Virus to an Individual Who Buried an Infected Cat. 重症发热伴血小板减少综合征病毒可能传播给掩埋受感染猫的人。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.425

Hirohisa Mekata, Takeshi Kawaguchi, Kosho Iwao, Kazumi Umeki, Kentaro Yamada, Kunihiko Umekita, Tamaki Okabayashi

{"title":"Possible Transmission of Severe Fever with the Thrombocytopenia Syndrome Virus to an Individual Who Buried an Infected Cat.","authors":"Hirohisa Mekata, Takeshi Kawaguchi, Kosho Iwao, Kazumi Umeki, Kentaro Yamada, Kunihiko Umekita, Tamaki Okabayashi","doi":"10.7883/yoken.JJID.2022.425","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.425","url":null,"abstract":"Severe fever with thrombocytopenia syndrome (SFTS) is caused by the severe fever with thrombocytopenia syndrome virus (SFTSV). Although SFTS is a fatal tick-borne zoonosis, it can infect humans without tick bite exposure. Recently, direct transmission of SFTSV from companion pets to humans has become a major problem. We present a case of SFTSV transmission from a dead community cat to a woman who buried the cat in Miyazaki Prefecture, Japan. The community cat died without a diagnosis of SFTS, and the woman buried it without taking any precautions. She developed symptoms of SFTS 9 days later. The woman tested positive for SFTS viral RNA and anti-SFTSV antibodies. The cat's carcass was exhumed, and tissue samples were collected to confirm the viral infection. Numerous copies of viral RNA were detected. The SFTSV M segment sequences in the cat and the woman were 100% homologous. The woman claimed that she had touched blood that had leaked from the cat's body while burying it. However, she could have been infected while transporting the cat to the animal hospital. This study highlights the risk of SFTSV infection from contact with sick or dead community cats.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

RBF Protein with MA103 Adjuvant Elicited Protective Immunity against Human Respiratory Syncytial Virus in BALB/c Mice. 含MA103佐剂的RBF蛋白诱导BALB/c小鼠对人呼吸道合胞病毒的保护性免疫

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.476

Qiongqiong Fang, Hai Li, Hu Ren, Lei Cao, Hongqiao Hu, Yan Zhang, Wenbo Xu

引用次数: 0

A METTL3 Inhibitor Alleviates the Onset of Osteomyelitis in a Mouse Model by Targeting MyD88. METTL3抑制剂通过靶向MyD88减轻小鼠骨髓炎的发作

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-05-24 DOI: 10.7883/yoken.JJID.2022.454

Chuan-Yu Hu, Yong Jiao

{"title":"A METTL3 Inhibitor Alleviates the Onset of Osteomyelitis in a Mouse Model by Targeting MyD88.","authors":"Chuan-Yu Hu, Yong Jiao","doi":"10.7883/yoken.JJID.2022.454","DOIUrl":"https://doi.org/10.7883/yoken.JJID.2022.454","url":null,"abstract":"We aimed to study the effects of a methyltransferase 3 (METTL3) inhibitor on osteomyelitis. Bone marrow cells (BMs) and peripheral blood mononuclear cells (PBMCs) were isolated from osteomyelitis patients at our hospital. Primary BM-derived macrophages (BMDMs) were incubated with lipopolysaccharide (LPS), poly(I:C), or PAM3CSK4 after pretreatment with STM2457. S. aureus was injected into the intramedullary canal to construct an osteomyelitis C57BL/6 mice model, which was then treated with STM2457. Body weights, μCT three-dimensional analyses, and bacterial burdens of the mice were obtained. Up-regulated METTL3 expression was found in both BMs and PBMCs of osteomyelitis patients. LPS and PAM3CSK4-induced IL-6 and TNF-α secretion in BMDMs could be inhibited by STM2457 pretreatment, while STM2457 pretreatment did not affect the relative expression of NOS2, IL-6, and TNF-α after incubation with poly(I:C). STM2457 alleviated the symptoms of osteomyelitis in mice with increased body weights, diminished reactive bone formation and cortical bone loss, increased bacterial burdens, and decreased IL-6 and TNF-α secretion. STM2457 pretreatment down-regulated the relative expression of myeloid differentiation factor 88 (MyD88), p-TAK, and p-IKKα/β in LPS-stimulated BMDMs, while it did not show any effect on poly(I:C)-stimulated BMDMs. STM2457 alleviates the onset of osteomyelitis in mice by down-regulating the relative expression of MyD88 and NF-κB relevant inflammation molecules in macrophages.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0