Japanese journal of infectious diseases最新文献_第9页

Extensively Drug-Resistant Klebsiella pneumoniae Associated with Complicated Urinary Tract Infection in Northern India. 印度北部与并发尿路感染有关的广泛耐药肺炎克雷伯菌。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.009

Parinitha Kaza, Basil Britto Xavier, Jaspreet Mahindroo, Nisha Singh, Stephen Baker, To Nguyen Thi Nguyen, Ravimohan Suryanarayana Mavuduru, Balvinder Mohan, Neelam Taneja

{"title":"Extensively Drug-Resistant Klebsiella pneumoniae Associated with Complicated Urinary Tract Infection in Northern India.","authors":"Parinitha Kaza, Basil Britto Xavier, Jaspreet Mahindroo, Nisha Singh, Stephen Baker, To Nguyen Thi Nguyen, Ravimohan Suryanarayana Mavuduru, Balvinder Mohan, Neelam Taneja","doi":"10.7883/yoken.JJID.2023.009","DOIUrl":"10.7883/yoken.JJID.2023.009","url":null,"abstract":"Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. Understanding the genetic epidemiology of XDR-Kp can help determine its potential to be hypervirulent (hv) through the presence of siderophores. We characterized the genomes of 18 colistin-resistant XDR-Kp isolated from 14 patients with complicated tract infection at an Indian healthcare facility. The 18 organisms comprised the following sequence types (STs): ST14 (n = 9), ST147 (n = 5), ST231 (n = 2), ST2096 (n = 1), and ST25 (n = 1). Many patients in each ward were infected with the same ST, suggesting a common source of infection. Some patients had recurrent infections with multiple STs circulating in the ward, providing evidence of hospital transmission. β-lactamase genes (blaCTX-M-1, blaSHV, and blaampH) were present in all isolates. blaNDM-1 was present in 15 isolates, blaOXA-1 in 16 isolates, blaTEM-1D in 13 isolates, and blaOXA-48 in 3 isolates. Disruption of mgrB by various insertion sequences was responsible for colistin resistance in 6 isolates. The most common K-type among isolates was K2 (n = 10). One XDR convergent hvKp ST2096 mutation (iuc+ybt+blaOXA-1+blaOXA-48) was associated with prolonged hospitalization. Convergent XDR-hvKp has outbreak potential, warranting effective antimicrobial stewardship and infection control.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"7-15"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Long-Term Serological Profile of CoronaVac Vaccine Based on Comorbidities and History of SARS-CoV-2 Infection in Indonesia. 基于印尼合并症和严重急性呼吸系统综合征冠状病毒2型感染史的冠状病毒疫苗的长期血清学特征。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-10-31 DOI: 10.7883/yoken.JJID.2023.061

Syahrul Chilmi, Tanti Adelia Kesuma, Purwa Adrianta Wibawa, Hani Susianti, Agustin Iskandar, Indah Adhita Wulanda, Caesarius Singgih Wahono, Kusworini Handono

引用次数: 0

Cleavage-Activation of Respiratory Viruses - Half a Century of History from Sendai Virus to SARS-CoV-2. 呼吸道病毒的裂解激活——从仙台病毒到SARS-CoV-2的半个世纪历史。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-11-30 DOI: 10.7883/yoken.JJID.2023.353

Makoto Takeda

{"title":"Cleavage-Activation of Respiratory Viruses - Half a Century of History from Sendai Virus to SARS-CoV-2.","authors":"Makoto Takeda","doi":"10.7883/yoken.JJID.2023.353","DOIUrl":"10.7883/yoken.JJID.2023.353","url":null,"abstract":"Many viruses require the cleavage-activation of membrane fusion proteins by host proteases in the course of infection. This knowledge is based on historical studies of Sendai virus in the 1970s. From the 1970s to the 1990s, avian influenza virus and Newcastle disease virus were studied, showing a clear link between virulence and the cleavage-activation of viral membrane fusion proteins (hemagglutinin and fusion proteins) by host proteases. In these viruses, cleavage of viral membrane fusion proteins by furin is the basis for their high virulence. Subsequently, from the 2000s to the 2010s, the importance of TMPRSS2 in activating the membrane fusion proteins of various respiratory viruses, including seasonal influenza viruses, was demonstrated. In late 2019, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) emerged and caused a pandemic. The virus continues to mutate, producing variants that have caused global pandemics. The spike protein of SARS-CoV-2 is characterized by two cleavage sites, each of which is cleaved by furin and TMPRSS2 to achieve membrane fusion. SARS-CoV-2 variants exhibit altered sensitivity to these proteases. Thus, studying the cleavage-activation of membrane fusion proteins by host proteases is critical for understanding the ongoing pandemic and developing countermeasures against it.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138459898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmission Cycle of Shimokoshi-Type Orientia tsutsugamushi in Shimane Prefecture, Japan. 日本岛根县下越型恙虫病的传播周期。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.137

Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara

{"title":"Transmission Cycle of Shimokoshi-Type Orientia tsutsugamushi in Shimane Prefecture, Japan.","authors":"Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara","doi":"10.7883/yoken.JJID.2023.137","DOIUrl":"10.7883/yoken.JJID.2023.137","url":null,"abstract":"To demonstrate the transmission cycle of Shimokoshi-type Orientia tsutsugamushi in Shimane Prefecture, field rodents were captured from areas where four human infections caused by the pathogen have been reported. The rodents were investigated for the transmission cycle of the pathogen based on the pathogen's genome, antibodies against the pathogen, and the vector of the pathogen (Leptotrombidium palpale). In addition, the vector was captured from the soil in the study area. A total of 44 rodents were captured. No O. tsutsugamushi DNA was detected in the blood or spleen samples by real-time polymerase chain reaction. However, a specific antibody against the pathogen was detected in 2 out of 44 (4.5%) rodents using the indirect immunoperoxidase method, indicating the presence of the pathogen in the study area. Although 29 L. palpale were identified, DNA detection was not performed because of the insufficient number of vectors, based on the DNA detection rate in previous studies. However, the identification of the vector, as well as the specific antibody in rodents, suggests the presence of the transmission cycle of Shimokoshi-type O. tsutsugamushi in Shimane Prefecture.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"55-58"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10120795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardization of the Japanese National Standard, Equine Botulinum Antitoxin Type A, and Factors Affecting Standardization. 日本国家标准《A 型马肉毒杆菌毒素》的标准化及影响标准化的因素。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.063

Masahiro Yutani, Mitsutoshi Senoh, Hiroko Yano, Tsuyoshi Kenri, Masaaki Iwaki

{"title":"Standardization of the Japanese National Standard, Equine Botulinum Antitoxin Type A, and Factors Affecting Standardization.","authors":"Masahiro Yutani, Mitsutoshi Senoh, Hiroko Yano, Tsuyoshi Kenri, Masaaki Iwaki","doi":"10.7883/yoken.JJID.2023.063","DOIUrl":"10.7883/yoken.JJID.2023.063","url":null,"abstract":"Equine botulinum antitoxin is one of the most popular countermeasures for human botulism. The unitage of the antitoxin product is defined according to national minimum requirement or pharmacopoeia in each country by referring to national standard antitoxins for four types (A, B, E, and F). With the expected depletion of the national standard antitoxins, replacement national standard antitoxins are produced and standardized through collaboration of the National Control Laboratory and other participants, including manufacturer(s). Therefore, Japanese National Standard Botulinum Antitoxin Type A, Equine, was replaced according to the results of a collaborative study involving the National Institute of Infectious Diseases and KM Biologics Co., Ltd. The unitage of the replacement material was determined through mouse neutralization tests, which involved toxin-antitoxin mixture injection at pH 7.0. Potency value of 440 units/vial was obtained. However, the Japanese Minimum Requirement for Biological Products was revised, and the neutralization reactions were repeated at pH 6.0, for which considerably different potency value (656 units/vial) and survival profile of mice were obtained. In September 2021, the replacement material, Japanese National Standard Botulinum Antitoxin Type A, Equine, lot 2, was established with potency value of 656 Units/vial. The impact of pH-dependent change in potency on antitoxin quality control is discussed.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"16-20"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10176960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Keratinocyte Entry of Noninvasive Streptococcus dysgalactiae Subsp. equisimilis from Humans and Companion Animals: Relatedness with Lancefield Group, Source, Virulence-Associated Genes, and Antimicrobial Resistance Phenotype. 人角质形成细胞进入非侵袭性半乳糖链球菌亚种。人类和伴侣动物的相似性：与兰斯菲尔德组、来源、毒力相关基因和抗微生物耐药性表型的相关性。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-09-29 DOI: 10.7883/yoken.JJID.2023.310

Haruno Yoshida, Yoshiko Takayama, Mieko Goto, Takahiro Maeda, Yuzo Tsuyuki, Takashi Takahashi

{"title":"Human Keratinocyte Entry of Noninvasive Streptococcus dysgalactiae Subsp. equisimilis from Humans and Companion Animals: Relatedness with Lancefield Group, Source, Virulence-Associated Genes, and Antimicrobial Resistance Phenotype.","authors":"Haruno Yoshida, Yoshiko Takayama, Mieko Goto, Takahiro Maeda, Yuzo Tsuyuki, Takashi Takahashi","doi":"10.7883/yoken.JJID.2023.310","DOIUrl":"10.7883/yoken.JJID.2023.310","url":null,"abstract":"We evaluated the cell invasion ability (CIA) of non-invasive Streptococcus dysgalactiae subsp. equisimilis using human keratinocytes and determined the association of CIA populations with their hosts and microbiological traits. Forty-two isolates from humans and companion animals were selected with host information. In addition to CIA, virulence-associated gene (VAG, spegg-ska-scpA-inlA-sicG-brpA-prtF1-prtF2-lmb-cbp-srtp1-srtp2) profiling, emm genotyping, multilocus sequence typing, and antimicrobial resistance (AMR) phenotyping/genotyping were performed. We designated CIA values higher than the mean of all isolates as high-frequency and those lower than the mean as low-frequency. Differences in the CIA between the different sources and Lancefield groups were assessed. We analyzed the association between high- and low-frequency CIA and VAG, emm genotype, sequence type/clonal complex, and AMR phenotype/genotype. Based on the mean (19.368 colony-forming units/100 cells) of 42 isolates, eight isolates had high-frequency CIA, whereas 34 had low-frequency CIA. We found an association between low-frequency CIA population and group G isolates, as well as a link between high-frequency CIA population and group C isolates. We also observed associations between low-frequency CIA population and oral/respiratory tract origin, ska, scpA, and lmb detection, and the AMR phenotype. Our observations suggest potential associations between high-/low-frequency CIA and the group, source, VAG, and AMR phenotypes.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"25-33"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41125191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Tuberculosis Incidence among Interferon-Gamma Release Assay-Positive Individuals with Latent Tuberculosis Infection and Fibrotic Lesions in a Vulnerable Urban Population in Osaka City, Japan, 2015-2021. 2015-2021年，日本大阪市城市弱势人群中干扰素γ释放检测阳性潜伏性肺结核感染伴纤维病变的肺结核发病率。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-09-29 DOI: 10.7883/yoken.JJID.2023.277

Jun Komukai, Kenji Matsumoto, Wakaba Fukushima, Shinzoh Kudoh

{"title":"Pulmonary Tuberculosis Incidence among Interferon-Gamma Release Assay-Positive Individuals with Latent Tuberculosis Infection and Fibrotic Lesions in a Vulnerable Urban Population in Osaka City, Japan, 2015-2021.","authors":"Jun Komukai, Kenji Matsumoto, Wakaba Fukushima, Shinzoh Kudoh","doi":"10.7883/yoken.JJID.2023.277","DOIUrl":"10.7883/yoken.JJID.2023.277","url":null,"abstract":"Latent tuberculosis infection (LTBI) with fibrotic lesions (FL) can progress to active tuberculosis (TB). Most previous studies have used tuberculin skin tests, which have lower specificity than interferon-gamma release assays (IGRAs), for LTBI diagnosis. This study evaluated the incidence of active TB among individuals with LTBI (diagnosed using IGRAs) and FL in Nishinari District, Osaka City. In total, 54 men (mean age: 68.7 years) were enrolled, of whom 10 (18.5%) were homeless, and 36 (66.7%) were welfare recipients. The median observation period was 1,084 days (range: 64-2,907 days). The incidence rate of active TB among individuals with LTBI and FL was 1.18 (95% confidence interval: 0.32-4.29) cases per 100 person-years. Among the 19 participants who had not been treated with anti-TB therapy, one (5.3%) progressed to active TB, and among the 30 participants who had completed anti-TB treatment, one (3.3%) progressed to active TB. The other 5 participants did not have TB. This study revealed the incidence of active TB among individuals with LTBI, diagnosed using IGRAs, and FL in a vulnerable urban population. The higher incidence than that reported in previous studies reinforces the importance of improved LTBI management strategies, including chest radiography screening, and LTBI treatment.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"21-24"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of Toxin Genes and Polymerase Chain Reaction-Based Open Reading Frame Type Analyses for Severe Staphylococcus aureus Infection in Children. 毒素基因和基于聚合酶链式反应的开放阅读框类型分析对儿童严重金黄色葡萄球菌感染的重要性。

IF 1.3 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-01 DOI: 10.7883/yoken.Erratum.2024.E001

Noriko Takeuchi, Naruhiko Ishiwada

引用次数: 0

Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome 胰腺损伤与严重发热伴血小板减少综合征的不良预后有关

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2022.571

Mengke Yang, Yang Yang, Aiping Zhang, Mingyue Ni, Manman Liang, Bin Quan, Wenzheng Han, Jianghua Yang

{"title":"Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome","authors":"Mengke Yang, Yang Yang, Aiping Zhang, Mingyue Ni, Manman Liang, Bin Quan, Wenzheng Han, Jianghua Yang","doi":"10.7883/yoken.jjid.2022.571","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2022.571","url":null,"abstract":"Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease. Previous studies have mainly focused on the epidemiological and clinical characteristics of patients with SFTS, while pancreatic injury has received little attention. The purpose of this study is to investigate the effect of pancreatic injury on the prognosis of patients with SFTS. A total of 156 SFTS patients were included in the analysis from April 2016 to April 2022. Multivariable logistic regression analysis showed that pancreatic injury (OR=3.754, 95% CI 1.361-79.036, P=0.024) and neurological symptoms (OR=18.648, 95% CI 4.921-70.668, P<0.001) were independent risk factors for patient death. The receiver operating characteristic (ROC) curve indicated that serum pancreatic enzymes (PEs) were predictive of progression to death in SFTS patients. The area under the curve (AUC) for amylase (AMY) was 0.711, with an optimal cut-off value of 95.5 (U/L), sensitivity of 96.4%, and specificity of 35.9%. Lipase (LIP) had an AUC of 0.754, an optimal cut-off value of 354.75 (U/L), a sensitivity of 75%, and a specificity of 67.2%. Thus, pancreatic injury is associated with a poor prognosis of SFTS and can be used as an important reference for SFTS disease determination and prognostic assessment.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"15 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139051131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DYSREGULATED LEUKOTRIENE METABOLISM IN COVID-19 PATIENTS Covid-19患者的白三烯代谢失调

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.211

Halef Okan Doğan, Mahir Budak, Kübra Doğan, Gözde Ertürk Zararsız, Serra İlayda Yerlitaş, Serkan Bolat, Onur Şenol, Seyit Ali Büyüktuna, Ergun Pınarbaşı, Rağıp Sarıismailoğlu, Hayrettin Yavuz

{"title":"DYSREGULATED LEUKOTRIENE METABOLISM IN COVID-19 PATIENTS","authors":"Halef Okan Doğan, Mahir Budak, Kübra Doğan, Gözde Ertürk Zararsız, Serra İlayda Yerlitaş, Serkan Bolat, Onur Şenol, Seyit Ali Büyüktuna, Ergun Pınarbaşı, Rağıp Sarıismailoğlu, Hayrettin Yavuz","doi":"10.7883/yoken.jjid.2023.211","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.211","url":null,"abstract":"The aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and mRNA expressions of 5-LO, ALOX5AP and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. As compared to the control group, both non-ICU and ICU groups had lower levels of 5-LO and mRNA expression. ICU patients had lower levels of 5-LO and mRNA expression compared with non-ICU patients. The expression of CYSLTR1 mRNA was higher in patients compared to healthy controls. CYSLTR1 mRNA expression was found to be higher in ICU group than in non-ICU group. CYSLT levels were higher in the control group compared to both non-ICU and ICU patients. Due to the higher expressions of CYSLTR1 in patients than control group, selective leukotriene receptor blockers can be used as a treatment option. CYSLTR1 expressions were also higher in ICU group than non-ICU group. Thus, CYSLTR1 mRNA expression could be a promising biomarker of COVID-19 severity.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"81 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0