Jihye Um, Chad Douglas Nix, William Bill Messer, Yerun Zhu, Jun-Sun Park, Matthew Harmon Collins, BumSik Chin
{"title":"Long-Term Immunity after Vaccination against Yellow Fever in Korean Travelers.","authors":"Jihye Um, Chad Douglas Nix, William Bill Messer, Yerun Zhu, Jun-Sun Park, Matthew Harmon Collins, BumSik Chin","doi":"10.7883/yoken.JJID.2023.290","DOIUrl":null,"url":null,"abstract":"<p><p>Although a live-attenuated yellow fever (YF) vaccine is known to elicit durable immunity, antibody titers may wane after vaccination. This study evaluated long-term immunity after vaccination against YF among individuals who resided in Korea and were vaccinated with YF virus- 17D prior to international travel. Serum was collected between December 2018 and December 2019 at the National Medical Center, Republic of Korea, from YF vaccine recipients who had been vaccinated for more than five years prior to sample collection. Long-term immunity against YF was assessed using three serological assays: IgG enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA), and the focus reduction neutralization test (FRNT). Sixty-seven patients were enrolled in this study. The overall positivity rates for 50% focus reduction neutralization test (FRNT<sub>50</sub> ), IFA, and ELISA in a time-variable cross-sectional sample of the cohort were 97.0%, 86.6%, and 26.9%, respectively. While 93.8% (15/16) of samples collected ≥10 years post-vaccination remained positive by FRNT<sub>50</sub> , a significant inverse correlation was observed between FRNT<sub>50</sub> titer and interval after vaccination (R = - 0.385, P = 0.001). Humoral immunity against YF was well preserved among Korean individuals who were vaccinated more than five years ago. IFA testing yielded results similar to those of FRNT<sub>50</sub> testing, which may justify the further development of IFA to screen for waning immunity among those with previous YF vaccination.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"79-84"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of infectious diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7883/yoken.JJID.2023.290","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Although a live-attenuated yellow fever (YF) vaccine is known to elicit durable immunity, antibody titers may wane after vaccination. This study evaluated long-term immunity after vaccination against YF among individuals who resided in Korea and were vaccinated with YF virus- 17D prior to international travel. Serum was collected between December 2018 and December 2019 at the National Medical Center, Republic of Korea, from YF vaccine recipients who had been vaccinated for more than five years prior to sample collection. Long-term immunity against YF was assessed using three serological assays: IgG enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA), and the focus reduction neutralization test (FRNT). Sixty-seven patients were enrolled in this study. The overall positivity rates for 50% focus reduction neutralization test (FRNT50 ), IFA, and ELISA in a time-variable cross-sectional sample of the cohort were 97.0%, 86.6%, and 26.9%, respectively. While 93.8% (15/16) of samples collected ≥10 years post-vaccination remained positive by FRNT50 , a significant inverse correlation was observed between FRNT50 titer and interval after vaccination (R = - 0.385, P = 0.001). Humoral immunity against YF was well preserved among Korean individuals who were vaccinated more than five years ago. IFA testing yielded results similar to those of FRNT50 testing, which may justify the further development of IFA to screen for waning immunity among those with previous YF vaccination.
期刊介绍:
Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.