发热伴血小板减少综合征患者心脏损伤的特点。

IF 1.1 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2025-09-19 Epub Date: 2025-03-31 DOI:10.7883/yoken.JJID.2024.254
Jing Sun, Yao Hao, Junying Niu, Zhixiang Du, Jianghua Yang
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引用次数: 0

摘要

本研究旨在描述诊断为严重发热伴血小板减少综合征(SFTS)的个体心脏损伤的特征,并确定其与预后的关系。回顾性分析了2021年1月至2023年12月期间诊断为SFTS的324例患者,将患者分为生存组和非生存组。单变量和多变量分析确定了重要指标并预测了死亡危险因素。两组患者在年龄、高血压史、有无腹泻、瘀点、神经系统异常和许多实验室指标等方面存在统计学差异。这些指标包括淋巴细胞、单核细胞和血小板计数,以及肝酶水平、肾功能标志物、心脏生物标志物、凝血因子、炎症标志物、大别班达病毒RNA、心率、PR间期、QT间期和ST段抑郁发生率。年龄、高血压史、神经异常、Cr、PT和QT间期是死亡率的独立危险因素。SFTS患者病毒性心肌炎发生率为64.12%,非生存组心脏损伤发生率更高,且更早、更严重。SFTS患者病毒性心肌炎的发生率与预后密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characteristics of Cardiac Injury in Patients Diagnosed with Severe Fever with Thrombocytopenia Syndrome.

This study aimed to characterize cardiac injury in individuals diagnosed with severe fever with thrombocytopenia syndrome (SFTS) and to ascertain its relationship with prognosis. A retrospective analysis of data from 324 patients, diagnosed with SFTS between January 2021 and December 2023, was performed. Patients were categorized into survival and non-survival groups. Univariate and multivariate analyses were performed to identify significant indicators and predictive risk factors for mortality. Statistically significant differences in various parameters were found between the 2 groups, including age, history of hypertension, presence of diarrhea, petechiae, neurological abnormalities, and numerous laboratory measurements. These included lymphocyte, monocyte, and platelet counts, as well as liver enzyme levels, kidney function markers, cardiac biomarkers, clotting factors, inflammatory markers, Dabie Banda virus RNA, heart rate, PR interval, QT interval, and incidence of ST depression. Age, history of hypertension, neurological abnormalities, and creatinine, prothrombin time, and QT intervals were independent risk factors for mortality. The incidence of viral myocarditis in patients with SFTS was 64.12%, and the non-survival group demonstrated a higher incidence of cardiac injury, both earlier and more severe. The incidence of viral myocarditis in patients with SFTS was closely associated with prognosis.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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