Japanese journal of infectious diseases最新文献_第7页

Transmission Cycle of Shimokoshi-Type Orientia tsutsugamushi in Shimane Prefecture, Japan. 日本岛根县下越型恙虫病的传播周期。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.137

Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara

{"title":"Transmission Cycle of Shimokoshi-Type Orientia tsutsugamushi in Shimane Prefecture, Japan.","authors":"Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara","doi":"10.7883/yoken.JJID.2023.137","DOIUrl":"10.7883/yoken.JJID.2023.137","url":null,"abstract":"To demonstrate the transmission cycle of Shimokoshi-type Orientia tsutsugamushi in Shimane Prefecture, field rodents were captured from areas where four human infections caused by the pathogen have been reported. The rodents were investigated for the transmission cycle of the pathogen based on the pathogen's genome, antibodies against the pathogen, and the vector of the pathogen (Leptotrombidium palpale). In addition, the vector was captured from the soil in the study area. A total of 44 rodents were captured. No O. tsutsugamushi DNA was detected in the blood or spleen samples by real-time polymerase chain reaction. However, a specific antibody against the pathogen was detected in 2 out of 44 (4.5%) rodents using the indirect immunoperoxidase method, indicating the presence of the pathogen in the study area. Although 29 L. palpale were identified, DNA detection was not performed because of the insufficient number of vectors, based on the DNA detection rate in previous studies. However, the identification of the vector, as well as the specific antibody in rodents, suggests the presence of the transmission cycle of Shimokoshi-type O. tsutsugamushi in Shimane Prefecture.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10120795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Keratinocyte Entry of Noninvasive Streptococcus dysgalactiae Subsp. equisimilis from Humans and Companion Animals: Relatedness with Lancefield Group, Source, Virulence-Associated Genes, and Antimicrobial Resistance Phenotype. 人角质形成细胞进入非侵袭性半乳糖链球菌亚种。人类和伴侣动物的相似性：与兰斯菲尔德组、来源、毒力相关基因和抗微生物耐药性表型的相关性。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-09-29 DOI: 10.7883/yoken.JJID.2023.310

Haruno Yoshida, Yoshiko Takayama, Mieko Goto, Takahiro Maeda, Yuzo Tsuyuki, Takashi Takahashi

{"title":"Human Keratinocyte Entry of Noninvasive Streptococcus dysgalactiae Subsp. equisimilis from Humans and Companion Animals: Relatedness with Lancefield Group, Source, Virulence-Associated Genes, and Antimicrobial Resistance Phenotype.","authors":"Haruno Yoshida, Yoshiko Takayama, Mieko Goto, Takahiro Maeda, Yuzo Tsuyuki, Takashi Takahashi","doi":"10.7883/yoken.JJID.2023.310","DOIUrl":"10.7883/yoken.JJID.2023.310","url":null,"abstract":"We evaluated the cell invasion ability (CIA) of non-invasive Streptococcus dysgalactiae subsp. equisimilis using human keratinocytes and determined the association of CIA populations with their hosts and microbiological traits. Forty-two isolates from humans and companion animals were selected with host information. In addition to CIA, virulence-associated gene (VAG, spegg-ska-scpA-inlA-sicG-brpA-prtF1-prtF2-lmb-cbp-srtp1-srtp2) profiling, emm genotyping, multilocus sequence typing, and antimicrobial resistance (AMR) phenotyping/genotyping were performed. We designated CIA values higher than the mean of all isolates as high-frequency and those lower than the mean as low-frequency. Differences in the CIA between the different sources and Lancefield groups were assessed. We analyzed the association between high- and low-frequency CIA and VAG, emm genotype, sequence type/clonal complex, and AMR phenotype/genotype. Based on the mean (19.368 colony-forming units/100 cells) of 42 isolates, eight isolates had high-frequency CIA, whereas 34 had low-frequency CIA. We found an association between low-frequency CIA population and group G isolates, as well as a link between high-frequency CIA population and group C isolates. We also observed associations between low-frequency CIA population and oral/respiratory tract origin, ska, scpA, and lmb detection, and the AMR phenotype. Our observations suggest potential associations between high-/low-frequency CIA and the group, source, VAG, and AMR phenotypes.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41125191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Tuberculosis Incidence among Interferon-Gamma Release Assay-Positive Individuals with Latent Tuberculosis Infection and Fibrotic Lesions in a Vulnerable Urban Population in Osaka City, Japan, 2015-2021. 2015-2021年，日本大阪市城市弱势人群中干扰素γ释放检测阳性潜伏性肺结核感染伴纤维病变的肺结核发病率。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-09-29 DOI: 10.7883/yoken.JJID.2023.277

Jun Komukai, Kenji Matsumoto, Wakaba Fukushima, Shinzoh Kudoh

{"title":"Pulmonary Tuberculosis Incidence among Interferon-Gamma Release Assay-Positive Individuals with Latent Tuberculosis Infection and Fibrotic Lesions in a Vulnerable Urban Population in Osaka City, Japan, 2015-2021.","authors":"Jun Komukai, Kenji Matsumoto, Wakaba Fukushima, Shinzoh Kudoh","doi":"10.7883/yoken.JJID.2023.277","DOIUrl":"10.7883/yoken.JJID.2023.277","url":null,"abstract":"Latent tuberculosis infection (LTBI) with fibrotic lesions (FL) can progress to active tuberculosis (TB). Most previous studies have used tuberculin skin tests, which have lower specificity than interferon-gamma release assays (IGRAs), for LTBI diagnosis. This study evaluated the incidence of active TB among individuals with LTBI (diagnosed using IGRAs) and FL in Nishinari District, Osaka City. In total, 54 men (mean age: 68.7 years) were enrolled, of whom 10 (18.5%) were homeless, and 36 (66.7%) were welfare recipients. The median observation period was 1,084 days (range: 64-2,907 days). The incidence rate of active TB among individuals with LTBI and FL was 1.18 (95% confidence interval: 0.32-4.29) cases per 100 person-years. Among the 19 participants who had not been treated with anti-TB therapy, one (5.3%) progressed to active TB, and among the 30 participants who had completed anti-TB treatment, one (3.3%) progressed to active TB. The other 5 participants did not have TB. This study revealed the incidence of active TB among individuals with LTBI, diagnosed using IGRAs, and FL in a vulnerable urban population. The higher incidence than that reported in previous studies reinforces the importance of improved LTBI management strategies, including chest radiography screening, and LTBI treatment.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of Toxin Genes and Polymerase Chain Reaction-Based Open Reading Frame Type Analyses for Severe Staphylococcus aureus Infection in Children. 毒素基因和基于聚合酶链式反应的开放阅读框类型分析对儿童严重金黄色葡萄球菌感染的重要性。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-01 DOI: 10.7883/yoken.Erratum.2024.E001

Noriko Takeuchi, Naruhiko Ishiwada

引用次数: 0

Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome 胰腺损伤与严重发热伴血小板减少综合征的不良预后有关

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2022.571

Mengke Yang, Yang Yang, Aiping Zhang, Mingyue Ni, Manman Liang, Bin Quan, Wenzheng Han, Jianghua Yang

{"title":"Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome","authors":"Mengke Yang, Yang Yang, Aiping Zhang, Mingyue Ni, Manman Liang, Bin Quan, Wenzheng Han, Jianghua Yang","doi":"10.7883/yoken.jjid.2022.571","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2022.571","url":null,"abstract":"Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease. Previous studies have mainly focused on the epidemiological and clinical characteristics of patients with SFTS, while pancreatic injury has received little attention. The purpose of this study is to investigate the effect of pancreatic injury on the prognosis of patients with SFTS. A total of 156 SFTS patients were included in the analysis from April 2016 to April 2022. Multivariable logistic regression analysis showed that pancreatic injury (OR=3.754, 95% CI 1.361-79.036, P=0.024) and neurological symptoms (OR=18.648, 95% CI 4.921-70.668, P<0.001) were independent risk factors for patient death. The receiver operating characteristic (ROC) curve indicated that serum pancreatic enzymes (PEs) were predictive of progression to death in SFTS patients. The area under the curve (AUC) for amylase (AMY) was 0.711, with an optimal cut-off value of 95.5 (U/L), sensitivity of 96.4%, and specificity of 35.9%. Lipase (LIP) had an AUC of 0.754, an optimal cut-off value of 354.75 (U/L), a sensitivity of 75%, and a specificity of 67.2%. Thus, pancreatic injury is associated with a poor prognosis of SFTS and can be used as an important reference for SFTS disease determination and prognostic assessment.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139051131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DYSREGULATED LEUKOTRIENE METABOLISM IN COVID-19 PATIENTS Covid-19患者的白三烯代谢失调

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.211

Halef Okan Doğan, Mahir Budak, Kübra Doğan, Gözde Ertürk Zararsız, Serra İlayda Yerlitaş, Serkan Bolat, Onur Şenol, Seyit Ali Büyüktuna, Ergun Pınarbaşı, Rağıp Sarıismailoğlu, Hayrettin Yavuz

{"title":"DYSREGULATED LEUKOTRIENE METABOLISM IN COVID-19 PATIENTS","authors":"Halef Okan Doğan, Mahir Budak, Kübra Doğan, Gözde Ertürk Zararsız, Serra İlayda Yerlitaş, Serkan Bolat, Onur Şenol, Seyit Ali Büyüktuna, Ergun Pınarbaşı, Rağıp Sarıismailoğlu, Hayrettin Yavuz","doi":"10.7883/yoken.jjid.2023.211","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.211","url":null,"abstract":"The aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and mRNA expressions of 5-LO, ALOX5AP and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. As compared to the control group, both non-ICU and ICU groups had lower levels of 5-LO and mRNA expression. ICU patients had lower levels of 5-LO and mRNA expression compared with non-ICU patients. The expression of CYSLTR1 mRNA was higher in patients compared to healthy controls. CYSLTR1 mRNA expression was found to be higher in ICU group than in non-ICU group. CYSLT levels were higher in the control group compared to both non-ICU and ICU patients. Due to the higher expressions of CYSLTR1 in patients than control group, selective leukotriene receptor blockers can be used as a treatment option. CYSLTR1 expressions were also higher in ICU group than non-ICU group. Thus, CYSLTR1 mRNA expression could be a promising biomarker of COVID-19 severity.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins 针对 18 种深渊病毒糖蛋白的抗体的交叉中和活性

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.400

Yusuke Inoue, Yoshihiro Kaku, Michiko Harada, Keita Ishijima, Yudai Kuroda, Kango Tatemoto, Milagros Virhuez-Mendoza, Ayano Nishino, Tsukasa Yamamoto, Satoshi Inoue, Aya Matsuu, Ken Maeda

{"title":"Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins","authors":"Yusuke Inoue, Yoshihiro Kaku, Michiko Harada, Keita Ishijima, Yudai Kuroda, Kango Tatemoto, Milagros Virhuez-Mendoza, Ayano Nishino, Tsukasa Yamamoto, Satoshi Inoue, Aya Matsuu, Ken Maeda","doi":"10.7883/yoken.jjid.2023.400","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.400","url":null,"abstract":"Some lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with expression plasmids of the glycoproteins of all 18 lyssaviruses were prepared, and cross-reactivity was evaluated via virus-neutralization tests using RABV, European bat lyssavirus-1 (EBLV-1), Duvenhage virus (DUVV), Mokola virus (MOKV), and Lagos bat virus (LBV). The sera against RABV vaccines showed cross-reactivity with EBLV-1 and DUVV, which both belong to phylogroup I. However, the reactivity with MOKV and LBV in phylogroup II was notably limited or below the detection level. Next, we compared the cross-reactivity of the polyclonal antibodies against all the lyssavirus glycoproteins. Polyclonal antibodies had high virus-neutralization titers against the same phylogroup<tt>,</tt> but not against different phylogroups. Our findings indicate that a new vaccine should be developed for pre- and post-exposure prophylaxis against lyssavirus infections. \u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017–2022 2017-2022 年 COVID-19 前后东日本人类偏肺病毒的分子流行病学

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.350

Kazuya Shirato, Reiko Suwa, Naganori Nao, Miyuki Kawase, Satoko Sugimoto, Yohei Kume, Mina Chishiki, Takashi Ono, Hisao Okabe, Sakurako Norito, Masatoki Sato, Hiroko Sakuma, Shigeo Suzuki, Mitsuaki Hosoya, Makoto Takeda, Koichi Hashimoto

{"title":"Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017–2022","authors":"Kazuya Shirato, Reiko Suwa, Naganori Nao, Miyuki Kawase, Satoko Sugimoto, Yohei Kume, Mina Chishiki, Takashi Ono, Hisao Okabe, Sakurako Norito, Masatoki Sato, Hiroko Sakuma, Shigeo Suzuki, Mitsuaki Hosoya, Makoto Takeda, Koichi Hashimoto","doi":"10.7883/yoken.jjid.2023.350","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.350","url":null,"abstract":"Human metapneumovirus (hMPV) is genetically classified into two major subgroups, A and B, based on attachment glycoprotein (G) gene sequences, and the A2 subgroup is further separated into three subdivisions A2a, A2b (A2b1), and A2c (A2b2). The appearance of subgroup A2c viruses carrying a 180- or 111-nucleotide duplication in the G gene (A2c180nt-dup or A2c111nt-dup) have been reported in Japan and Spain. The pandemic of coronavirus disease 2019 (COVID-19) disrupted the epidemiological kinetics of other respiratory viruses, including hMPV. In this study, we analysed the sequences of hMPV isolates obtained from 2017 to 2022 in Tokyo and Fukushima, i.e., before and after COVID-19. Subgroup A hMPVs were detected in 2017 to 2019, and most cases were A2c111nt-dup, suggesting there was continuous momentum of this clade, identical to the global situation. Subgroup B, but not subgroup A, viruses were detected in 2022, after the COVID-19 peak. Phylogenetic analysis showed that these resumed subgroup B viruses were closely related to the viruses detected in 2013 to 2016 in Yokohama and in 2019 in Fukushima, suggesting a reappearance of local endemic viruses in East Japan.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139062152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan 首次在日本关东地区的蜱虫中发现荆门蜱病毒

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI: 10.7883/yoken.jjid.2023.347

Ryo Matsumura, Daisuke Kobayashi, Kyo Itoyama, Haruhiko Isawa

{"title":"First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan","authors":"Ryo Matsumura, Daisuke Kobayashi, Kyo Itoyama, Haruhiko Isawa","doi":"10.7883/yoken.jjid.2023.347","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.347","url":null,"abstract":"In 2010, the Jingmen tick virus (JMTV) was discovered in ticks in China and has been shown to be distributed in several regions worldwide. Recently, cases of JMTV infection in humans have been reported in China and Kosovo, attracting much attention as an emerging tick-borne disease. In this study, we detected the JMTV genome in Amblyomma testudinarium ticks collected in Kanagawa Prefecture, Japan, during tick-borne virus surveillance conducted in the Kanto district. Phylogenetic analysis revealed that the new JMTV strain is closely related to previous strains detected in Japan. This suggests that JMTV may have been maintained during an independent natural transmission cycle in Japan. In addition, unlike in other countries and regions, all JMTV strains in Japan were detected only in A. testudinarium ticks, suggesting that this tick species is the primary JMTV vector in Japan. This report is the first to detect JMTV in the Kanto region. Further studies are required to elucidate the potential risk of infection by this tick-borne virus in Japan. In particular, the prevalence of JMTV in wild animals should be examined to clarify its geographical distribution, host range, and transmission cycle in nature.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139051135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myroides odoratimimus: a New Threat with Persistent Infections, Multidrug Resistance, and the Potential for Hospital Outbreaks. 多效密蝇:持续感染、多药耐药和可能在医院暴发的新威胁

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI: 10.7883/yoken.JJID.2023.005

Ismail Selcuk Aygar, Canset Nur Aydogan, Hande Ozcan, Irem Unat, Tugba Fatsa, Kemal Tekin, Aysun Yalci, Tugrul Hosbul, Fatih Sahiner, Ramazan Gumral

{"title":"Myroides odoratimimus: a New Threat with Persistent Infections, Multidrug Resistance, and the Potential for Hospital Outbreaks.","authors":"Ismail Selcuk Aygar, Canset Nur Aydogan, Hande Ozcan, Irem Unat, Tugba Fatsa, Kemal Tekin, Aysun Yalci, Tugrul Hosbul, Fatih Sahiner, Ramazan Gumral","doi":"10.7883/yoken.JJID.2023.005","DOIUrl":"10.7883/yoken.JJID.2023.005","url":null,"abstract":"Myroides species have recently been reported more frequently in outbreaks in clinics and intensive care units (ICUs). In this study, we aimed to investigate the epidemic potential, antibiotic resistance profile, and risk factors of M. odoratimimus isolates that are increasingly being isolated from the ICUs of our hospital. Data from patients whose Myroides spp. were isolated from their clinical specimens over a 5-year period (September 2016 to January 2022) were retrospectively analyzed. Bacterial identification was performed using a matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The presence of antibiotic resistance genes was analyzed using polymerase chain reaction (PCR). Possible clonal associations between isolates were investigated using enterobacterial repetitive intergenic consensus (ERIC)-PCR. As a result, 66 isolates were identified as M. odoratimimus and one isolate was identified as M. odoratus. The blaMUS resistance gene was detected in all M. odoratimimus isolates, whereas sul2 was detected in ten isolates and tetX was detected in 11 isolates. No other resistance genes, such as blaTUS, were detected. Additionally, two different clonal association patterns were discovered in the 24 selected isolates through the ERIC-PCR method. The increase in the immunosuppressive patient population indicate the possibility of encountering this agent and other opportunistic pathogens more frequently in the future.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0