Japanese journal of infectious diseases最新文献_第6页

Efficacy of cefiderocol, a novel siderophore cephalosporin, against multi-drug resistant Acinetobacter baumannii clinical isolates in Japan 新型嗜硒头孢菌素 cefiderocol 对日本耐多药鲍曼不动杆菌临床分离株的疗效

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-31 DOI: 10.7883/yoken.jjid.2023.364

Yoshitaka Kimura, Nami Hatayama, Yoshinori Sato, Satoshi Nishida, Yusuke Yoshino

{"title":"Efficacy of cefiderocol, a novel siderophore cephalosporin, against multi-drug resistant Acinetobacter baumannii clinical isolates in Japan","authors":"Yoshitaka Kimura, Nami Hatayama, Yoshinori Sato, Satoshi Nishida, Yusuke Yoshino","doi":"10.7883/yoken.jjid.2023.364","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.364","url":null,"abstract":"Multidrug-resistant Acinetobacter baumannii (MDRAB) is an important pathogen that causes nosocomial infections and is resistant to almost all antibiotics, including carbapenems. Cefiderocol is a novel siderophore cephalosporin that is active against a broad spectrum of Gram-negative bacteria. However, the susceptibility of MDRAB from Japan to cefiderocol has not yet been reported. In this study, we measured the minimum inhibitory concentrations (MICs) of antibiotics, including cefiderocol, against MDRAB clinical isolates collected during a nosocomial outbreak from 2009 to 2010 at Teikyo University Hospital in Japan. We found that all 10 MDRAB clinical isolates tested were susceptible to cefiderocol, with an MIC range of 0.12 to 1 μg/mL, all isolates were resistant to ampicillin-sulbactam, nine of the 10 isolates were susceptible to tigecycline, and all 10 isolates had an intermediate phenotype to colistin. DNA sequencing revealed that all strains harbored an OXA-51-like carbapenemase, one of the major causes of carbapenem resistance in A. baumannii in Japan. In conclusion, this study showed that susceptibility to cefiderocol of MDRAB clinical isolates in Japan was equivalent to that of colistin or tigecycline. Cefiderocol could be a possible choice for the treatment of MDRAB infections.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"8 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139583295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton pump inhibitors and risk of bloodstream infection without an identifiable source: a hospital-based case-control study 质子泵抑制剂与无法确定来源的血流感染风险：一项基于医院的病例对照研究

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-31 DOI: 10.7883/yoken.jjid.2023.253

Shintaro Hayashi, Tomohito Moriyama, Yuichiro Ito, Yuta Harada, Hiroki Dodo, Kana Kumahara, Tatsuji Yogi, Noritsugu Ohashi, Reiji Higashi, Akihiro Mori

{"title":"Proton pump inhibitors and risk of bloodstream infection without an identifiable source: a hospital-based case-control study","authors":"Shintaro Hayashi, Tomohito Moriyama, Yuichiro Ito, Yuta Harada, Hiroki Dodo, Kana Kumahara, Tatsuji Yogi, Noritsugu Ohashi, Reiji Higashi, Akihiro Mori","doi":"10.7883/yoken.jjid.2023.253","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.253","url":null,"abstract":"The association between proton-pump inhibitor (PPI) use and systemic infections caused by bacterial translocation is unclear. This study aims to investigate whether patients receiving PPI therapy have a higher risk for bloodstream infections (BSI) without an identifiable source of infection, as an alternative indicator of BSI secondary to bacterial translocation. We conducted a hospital-based case–control study which enrolled all patients aged 20 years and older who developed BSI confirmed by two sets of positive blood culture and had inpatient care in Ichinomiya-Nishi Hospital in 2019. Patients’ data were collected from medical records, and bacterial translocation type (BT-type) BSI group were defined as those who had BSI without an identifiable source of infection, whereas the others were classified control group based on the diagnostic criteria for each infectious disease. We analyzed data from 309 patients, including 66 cases and 243 controls. PPI users had a 2.4-fold higher risk of developing BT-type BSI compared to non-PPI-users after controlling for potential confounders (OR: 2.41, 95% CI: 1.29–4.51, p=0.006). In conclusion, PPI use is associated with higher risk of BSI without an identifiable source and therefore, PPI use may increase the risk of septic morbidity secondary to bacterial translocation.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"27 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139583293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofilm eradication of Stenotrophomonas maltophilia by Levofloxacin and Trimethoprim-sulfamethoxazole 左氧氟沙星和三甲氧苄氨嘧啶-磺胺甲噁唑对嗜麦芽糖单胞菌生物膜的根除作用

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-31 DOI: 10.7883/yoken.jjid.2023.389

José Mauricio Del Río-Chacón, Fabián Rojas-Larios, Paola Bocanegra-Ibarias, Daniel Salas-Treviño, Francisco Espinoza-Gómez, Adrián Camacho-Ortiz, Samantha Flores-Treviño

{"title":"Biofilm eradication of Stenotrophomonas maltophilia by Levofloxacin and Trimethoprim-sulfamethoxazole","authors":"José Mauricio Del Río-Chacón, Fabián Rojas-Larios, Paola Bocanegra-Ibarias, Daniel Salas-Treviño, Francisco Espinoza-Gómez, Adrián Camacho-Ortiz, Samantha Flores-Treviño","doi":"10.7883/yoken.jjid.2023.389","DOIUrl":"https://doi.org/10.7883/yoken.jjid.2023.389","url":null,"abstract":"Stenotrophomonas maltophilia is a non-fermenting Gram-negative drug-resistant pathogen causing healthcare-associated infections. Clinical isolates from Mexico were assessed for biofilm production by crystal violet staining. Antimicrobial susceptibility was evaluated using the broth microdilution method in planktonic and biofilm cells. The effect of antibiotics on the biofilm was visualized by fluorescence microscopy. Fifty isolates were included in the study, of which 28.0% were biofilm producers (64.2% from blood and 35.7% from respiratory samples). Resistance to levofloxacin (8.0%) and trimethoprim-sulfamethoxazole (44.0%) in planktonic cells increased to 100% in biofilm cells. Bacterial biofilm treated with several concentrations of both antibiotics was completely disrupted. In conclusion, S. maltophilia isolated from blood had higher biofilm production than those from respiratory samples. Resistance to antibiotics increased due to biofilm production. Antibiotic monotherapy might not be the best course of action for the treatment of S. maltophilia infections in Mexico, as they might also be causing biofilm production.\u0000","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"7 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139583394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Detection of Chimeric β-Lactamase CTX-M-64-Producing Salmonella Typhimurium from a Domestic Source in Japan. 日本首次检测到产嵌合型β-内酰胺酶 CTX-M-64 的鼠伤寒沙门氏菌。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.163

Tomu Kamijo, Kazuki Horiuchi, Tatsuya Negishi, Tatsuya Natori, Taku Yamane, Ayaka Hachiro, Takeshi Uehara, Wataru Hayashi, Noriyuki Nagano

{"title":"First Detection of Chimeric β-Lactamase CTX-M-64-Producing Salmonella Typhimurium from a Domestic Source in Japan.","authors":"Tomu Kamijo, Kazuki Horiuchi, Tatsuya Negishi, Tatsuya Natori, Taku Yamane, Ayaka Hachiro, Takeshi Uehara, Wataru Hayashi, Noriyuki Nagano","doi":"10.7883/yoken.JJID.2023.163","DOIUrl":"10.7883/yoken.JJID.2023.163","url":null,"abstract":"Salmonella enterica subsp. enterica serovar Typhimurium has recently emerged worldwide as a producer of extended-spectrum β-lactamase (ESBL). However, drug-resistant clinical isolates are rare in Japan. The common types of ESBLs found are the CTX-M-type β-lactamases, including novel β-lactamases such as CTX-M-64. CTX-M-64 has a chimeric structure comprising a combination of the CTX-M-1 and CTX-M-9 groups. In 2017, S. Typhimurium was isolated from stool, blood, and urine cultures of an 82-year-old man. Herein, we describe the discovery of a clinical isolate of S. Typhimurium in Japan. Antimicrobial susceptibility testing revealed that the isolate was resistant to third- and fourth-generation cephalosporins, including ceftazidime and monobactam. The minimum inhibitory concentrations of ceftazidime and ceftriaxone were restored by administration of clavulanic acid. Whole-genome sequencing analysis revealed that the isolate harbored the blaCTX-M-64 gene on an IncHI2/IncHI2A-type plasmid, with an assembly length of 174,477 bp. The genetic structure of the region surrounding the blaCTX-M-64 gene, ISKpn26-ΔISEcp1-blaCTX-M-64-orf477, was shared only with the chromosome sequence of S. Typhimurium detected in food-producing chickens in Guangdong, China. Although rare, S. Typhimurium can induce bloodstream infections and produce ESBL. To our knowledge, this is the first report of a CTX-M-64-producing Enterobacterales clinical isolate of domestic origin in Japan.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"47-50"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

General Vaccination Readiness in Japan: Results from the JASTIS 2023 Study. 日本的总体疫苗接种准备情况：JASTIS 2023研究结果。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-10-31 DOI: 10.7883/yoken.JJID.2023.261

Masaki Machida, Shigeru Inoue, Takahiro Tabuchi

{"title":"General Vaccination Readiness in Japan: Results from the JASTIS 2023 Study.","authors":"Masaki Machida, Shigeru Inoue, Takahiro Tabuchi","doi":"10.7883/yoken.JJID.2023.261","DOIUrl":"10.7883/yoken.JJID.2023.261","url":null,"abstract":"General vaccine hesitancy is a global concern. Clarifying general vaccination readiness and the psychological factors comprising it is important. Previous studies reported that Japan has one of the lowest vaccine confidence levels worldwide. However, the status of other psychological factors comprising general vaccination readiness in Japan remains unclear. Therefore, we aimed to clarify the status of seven psychological factors comprising general vaccination readiness and their patterns in Japan. This descriptive study utilized data from a large-scale nationwide internet survey (Japan Society and New Tobacco Internet Survey 2023 study, N = 31,037). Seven psychological factors were assessed using the 7C of vaccination readiness scale. Cluster analysis was performed using k-means++ clustering to clarify patterns. Of the seven factors, support for social monitoring of people refusing vaccination (e.g., vaccine passports) was very low among the participants. Cluster analysis showed that the participants' vaccination readiness could be classified into six patterns, of which the very low vaccination readiness cluster, with the lowest scores for most psychological factors, accounted for 11.1% and was more common among those aged 30-49 years (13.1-16.4%). Individuals in this cluster may refuse to receive recommended vaccines.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"34-39"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71423604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Difference in the Dynamics of Antibody Titers between COVID-19 Vaccination and SARS-CoV-2 Infection in Healthcare Workers - A Case Study Based on Long-Term and Densely Repeated Measurements of Antibody Titers. 医护人员新冠肺炎疫苗接种和SARS-CoV-2感染之间抗体滴度动态的差异——基于抗体滴度长期密集测量的病例研究。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-09-29 DOI: 10.7883/yoken.JJID.2023.175

Hirotaka Tanaka, Hiroyuki Sawatari, Shin-Ichi Ando

{"title":"Difference in the Dynamics of Antibody Titers between COVID-19 Vaccination and SARS-CoV-2 Infection in Healthcare Workers - A Case Study Based on Long-Term and Densely Repeated Measurements of Antibody Titers.","authors":"Hirotaka Tanaka, Hiroyuki Sawatari, Shin-Ichi Ando","doi":"10.7883/yoken.JJID.2023.175","DOIUrl":"10.7883/yoken.JJID.2023.175","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is prevalent worldwide, and effective and safe vaccines against this virus have been developed. Although trends in antibody titers after vaccination and/or SARS-CoV-2 infection have been reported, long-term studies with high frequency of measurements are limited. This report describes the long-term and detailed trends in the antibodies against SARS-CoV-2 S protein receptor-binding domain (S-RBD) measured repeatedly after vaccination and/or infection in 3 healthcare workers. All healthcare workers were administered 30 µg of the messenger RNA vaccine, BNT162b2, during all vaccinations. The peak value of the SARS-CoV-2 S-RBD titer was reached at 1-2 weeks after vaccination and then decreased by half within 8 weeks after vaccination; the peak values of the antibody titer increased with repeated vaccinations. In contrast, after SARS-CoV-2 infection, the peak value of the antibody titer was reached at 4-8 weeks after infection, and the antibody titer remained elevated up to 16-40 weeks after the peak. This report describes the long-term and detailed trends in the anti-SARS-CoV-2 S-RBD titers, showing different patterns after vaccination and/or SARS-CoV-2 infection.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"51-54"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extensively Drug-Resistant Klebsiella pneumoniae Associated with Complicated Urinary Tract Infection in Northern India. 印度北部与并发尿路感染有关的广泛耐药肺炎克雷伯菌。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.009

Parinitha Kaza, Basil Britto Xavier, Jaspreet Mahindroo, Nisha Singh, Stephen Baker, To Nguyen Thi Nguyen, Ravimohan Suryanarayana Mavuduru, Balvinder Mohan, Neelam Taneja

{"title":"Extensively Drug-Resistant Klebsiella pneumoniae Associated with Complicated Urinary Tract Infection in Northern India.","authors":"Parinitha Kaza, Basil Britto Xavier, Jaspreet Mahindroo, Nisha Singh, Stephen Baker, To Nguyen Thi Nguyen, Ravimohan Suryanarayana Mavuduru, Balvinder Mohan, Neelam Taneja","doi":"10.7883/yoken.JJID.2023.009","DOIUrl":"10.7883/yoken.JJID.2023.009","url":null,"abstract":"Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. Understanding the genetic epidemiology of XDR-Kp can help determine its potential to be hypervirulent (hv) through the presence of siderophores. We characterized the genomes of 18 colistin-resistant XDR-Kp isolated from 14 patients with complicated tract infection at an Indian healthcare facility. The 18 organisms comprised the following sequence types (STs): ST14 (n = 9), ST147 (n = 5), ST231 (n = 2), ST2096 (n = 1), and ST25 (n = 1). Many patients in each ward were infected with the same ST, suggesting a common source of infection. Some patients had recurrent infections with multiple STs circulating in the ward, providing evidence of hospital transmission. β-lactamase genes (blaCTX-M-1, blaSHV, and blaampH) were present in all isolates. blaNDM-1 was present in 15 isolates, blaOXA-1 in 16 isolates, blaTEM-1D in 13 isolates, and blaOXA-48 in 3 isolates. Disruption of mgrB by various insertion sequences was responsible for colistin resistance in 6 isolates. The most common K-type among isolates was K2 (n = 10). One XDR convergent hvKp ST2096 mutation (iuc+ybt+blaOXA-1+blaOXA-48) was associated with prolonged hospitalization. Convergent XDR-hvKp has outbreak potential, warranting effective antimicrobial stewardship and infection control.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"7-15"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Long-Term Serological Profile of CoronaVac Vaccine Based on Comorbidities and History of SARS-CoV-2 Infection in Indonesia. 基于印尼合并症和严重急性呼吸系统综合征冠状病毒2型感染史的冠状病毒疫苗的长期血清学特征。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-10-31 DOI: 10.7883/yoken.JJID.2023.061

Syahrul Chilmi, Tanti Adelia Kesuma, Purwa Adrianta Wibawa, Hani Susianti, Agustin Iskandar, Indah Adhita Wulanda, Caesarius Singgih Wahono, Kusworini Handono

引用次数: 0

Cleavage-Activation of Respiratory Viruses - Half a Century of History from Sendai Virus to SARS-CoV-2. 呼吸道病毒的裂解激活——从仙台病毒到SARS-CoV-2的半个世纪历史。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-11-30 DOI: 10.7883/yoken.JJID.2023.353

Makoto Takeda

{"title":"Cleavage-Activation of Respiratory Viruses - Half a Century of History from Sendai Virus to SARS-CoV-2.","authors":"Makoto Takeda","doi":"10.7883/yoken.JJID.2023.353","DOIUrl":"10.7883/yoken.JJID.2023.353","url":null,"abstract":"Many viruses require the cleavage-activation of membrane fusion proteins by host proteases in the course of infection. This knowledge is based on historical studies of Sendai virus in the 1970s. From the 1970s to the 1990s, avian influenza virus and Newcastle disease virus were studied, showing a clear link between virulence and the cleavage-activation of viral membrane fusion proteins (hemagglutinin and fusion proteins) by host proteases. In these viruses, cleavage of viral membrane fusion proteins by furin is the basis for their high virulence. Subsequently, from the 2000s to the 2010s, the importance of TMPRSS2 in activating the membrane fusion proteins of various respiratory viruses, including seasonal influenza viruses, was demonstrated. In late 2019, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) emerged and caused a pandemic. The virus continues to mutate, producing variants that have caused global pandemics. The spike protein of SARS-CoV-2 is characterized by two cleavage sites, each of which is cleaved by furin and TMPRSS2 to achieve membrane fusion. SARS-CoV-2 variants exhibit altered sensitivity to these proteases. Thus, studying the cleavage-activation of membrane fusion proteins by host proteases is critical for understanding the ongoing pandemic and developing countermeasures against it.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138459898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmission Cycle of Shimokoshi-Type Orientia tsutsugamushi in Shimane Prefecture, Japan. 日本岛根县下越型恙虫病的传播周期。

IF 2.2 4区医学

Japanese journal of infectious diseases Pub Date : 2024-01-24 Epub Date: 2023-08-31 DOI: 10.7883/yoken.JJID.2023.137

Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara

{"title":"Transmission Cycle of Shimokoshi-Type Orientia tsutsugamushi in Shimane Prefecture, Japan.","authors":"Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara","doi":"10.7883/yoken.JJID.2023.137","DOIUrl":"10.7883/yoken.JJID.2023.137","url":null,"abstract":"To demonstrate the transmission cycle of Shimokoshi-type Orientia tsutsugamushi in Shimane Prefecture, field rodents were captured from areas where four human infections caused by the pathogen have been reported. The rodents were investigated for the transmission cycle of the pathogen based on the pathogen's genome, antibodies against the pathogen, and the vector of the pathogen (Leptotrombidium palpale). In addition, the vector was captured from the soil in the study area. A total of 44 rodents were captured. No O. tsutsugamushi DNA was detected in the blood or spleen samples by real-time polymerase chain reaction. However, a specific antibody against the pathogen was detected in 2 out of 44 (4.5%) rodents using the indirect immunoperoxidase method, indicating the presence of the pathogen in the study area. Although 29 L. palpale were identified, DNA detection was not performed because of the insufficient number of vectors, based on the DNA detection rate in previous studies. However, the identification of the vector, as well as the specific antibody in rodents, suggests the presence of the transmission cycle of Shimokoshi-type O. tsutsugamushi in Shimane Prefecture.","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":" ","pages":"55-58"},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10120795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0