Characterization of proinflammatory cytokines profile during acute SARS-CoV-2 infection in people with human immunodeficiency virus.

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Alitzel Anzurez, Lucky Runtuwene, Thao Thi Thu Dang, Kaori Nakayama-Hosoya, Michiko Koga, Yukihiro Yoshimura, Hiroaki Sasaki, Nobuyuki Miyata, Kazuhito Miyazaki, Yoshimasa Takahashi, Tadaki Suzuki, Hiroshi Yotsuyanagi, Natsuo Tachikawa, Tetsuro Matano, Ai Kawana-Tachikawa
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引用次数: 0

Abstract

Persistent inflammation in chronic HIV infection may affect immune responses against SARS-CoV-2 infection. Plasma levels of multiple proinflammatory cytokines during acute SARS-CoV-2 infection were assessed in people with HIV (PWH) with effective cART. There were no significant differences in any of the tested cytokines between COVID-19 severity in PWH, while most of them were significantly higher in individuals with severe disease in HIV-uninfected individuals, suggesting that excess cytokines release by hyper-inflammatory responses does not occur in severe COVID-19 with HIV infection. The strong associations between the cytokines observed in HIV-uninfected individuals, especially between IFN-α/TNF-α and other cytokines, were lost in PWH. The steady state plasma levels of IP-10, ICAM-1, and CD62E were significantly higher in PWH, indicating that PWH are in an enhanced inflammatory state. Loss of the several inter-cytokine correlations were observed in in vitro LPS stimuli-driven cytokines production in PWH. These data suggest that inflammatory responses during SARS-CoV-2 infection in PWH are distinct from those in HIV-uninfected individuals, partially due to the underlying inflammatory state and/or impairment of innate immune cells.

人类免疫缺陷病毒感染者急性 SARS-CoV-2 感染期间促炎细胞因子的特征。
慢性艾滋病病毒感染者的持续炎症可能会影响对 SARS-CoV-2 感染的免疫反应。我们评估了接受有效抗病毒治疗的艾滋病病毒感染者(PWH)在急性 SARS-CoV-2 感染期间血浆中多种促炎细胞因子的水平。PWH的COVID-19严重程度不同,所检测的细胞因子均无明显差异,而在未感染HIV的重症患者中,大多数细胞因子的水平明显较高,这表明在感染HIV的重症COVID-19患者中,高炎症反应不会释放过多的细胞因子。在艾滋病毒未感染者中观察到的细胞因子之间的密切联系,尤其是 IFN-α/TNF-α 与其他细胞因子之间的密切联系,在 PWH 中消失了。在 PWH 中,血浆中 IP-10、ICAM-1 和 CD62E 的稳态水平明显升高,这表明 PWH 处于一种强化的炎症状态。在体外 LPS 刺激驱动的细胞因子产生过程中,也观察到 PWH 中多种细胞因子之间的相关性丧失。这些数据表明,PWH 感染 SARS-CoV-2 期间的炎症反应与未感染 HIV 的人不同,部分原因是潜在的炎症状态和/或先天免疫细胞受损。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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