Genetic Characteristics and Phylogenetic Analysis of Coxsackievirus A6 Isolated in Linyi, China, 2022-2023.

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2024-11-21 Epub Date: 2024-06-28 DOI:10.7883/yoken.JJID.2024.072
Jie Chen, Pengfei You, Xiaoyan Chen, Huafeng Li, Na Zhang, Guangyun Zhang, Conghong Xu, Chunling Ma, Yanli Zhang, Tiegang Lv
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引用次数: 0

Abstract

Hand, foot, and mouth disease (HFMD) has become one of the most common infectious diseases in the past few decades. Since 2013, coxsackievirus A6 (CVA6) has replaced enterovirus A71 (EV-A71) and coxsackievirus A16 (CVA16), becoming the predominant pathogen responsible for HFMD in many areas of China. This study aimed to investigate the genetic characteristics and molecular epidemiology of CVA6 in Linyi between the years 2022 and 2023. In total, 965 patients with HFMD were enrolled in this study, and analyses based on VP1 nucleotide sequences were performed to determine the evolutionary trajectory of CVA6. In 2022, 281/386 (72.8%) patients were positive for enteroviruses (EVs) and 217/281 (77.2%) were CVA6 positive. In 2023, 398/579 (68.7%) samples were positive for EVs and 243/398 (61.1%) were CVA6 positive. Six sequences were selected each year for homology analysis. The results showed that the 12 strains isolated from Linyi were distant from the prototype strain (AY421764) and the first CVA6 strain reported in China (JQ364886). Phylogenetic analysis showed that the CVA6 strains isolated from Linyi belonged to the D3 sub-genotype. CVA6 is emerging as a common pathogen causing HFMD in Linyi and continuous surveillance of HFMD etiologies agents is necessary.

2022-2023 年在中国临沂分离的柯萨奇病毒 A6 的遗传特征和系统发育分析。
手足口病(HFMD)是过去几十年中最常见的传染病之一。2013年后,柯萨奇病毒A6(CVA6)取代了肠道病毒71(EV-A71)和柯萨奇病毒A16(CVA16),成为中国许多地区手足口病的主要病原体。本研究旨在调查 2022 年至 2023 年临沂地区 CVA6 的遗传特征和分子流行病学。本研究共纳入 965 例手足口病病例,并基于 VP1 核苷酸序列进行分析,以确定 CVA6 的进化轨迹。2022 年,281 例(281/386,72.8%)肠道病毒 (EV) 阳性,217 例(217/281,77.2%)CVA6 阳性。2023 年,398 个样本(398/579,68.7%)对肠病毒呈阳性,243 个样本(243/398,61.1%)对 CVA6 呈阳性。每年选取 6 个序列进行同源性分析。结果表明,在临沂分离到的 12 株菌株与原型菌株(AY421764)和中国报道的首个 CVA6 菌株(JQ364886)相差甚远。系统进化分析表明,在临沂分离到的 CVA6 株系均属于 D3 亚基因型。CVA6 正在成为引起手足口病的常见病原体,因此有必要对手足口病的病原体进行持续监测。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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