Japanese Journal of Ophthalmology最新文献

{"title":"Implementation of pneumatic retinopexy in the Japanese population.","authors":"Kunihiko Akiyama, Takaaki Matsuki, Ken Watanabe, Aurora Pecaku, Sumana Naidu, Rajeev H Muni","doi":"10.1007/s10384-025-01241-z","DOIUrl":"https://doi.org/10.1007/s10384-025-01241-z","url":null,"abstract":"<p><strong>Purpose: </strong>To propose an implementation model for pneumatic retinopexy (PnR) in a region where PnR is performed infrequently, and to assess its impact on treatment of rhegmatogenous retinal detachment (RRD).</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>We reviewed 222 consecutive eyes with primary RRD treated from July 2017 to September 2023 at a tertiary care center in Japan. The treatment methods utilized included pars plana vitrectomy (PPV), scleral buckling (SB) and PnR. The surgeon learned PnR through social media. Primary anatomic reattachment rate (PARR) and visual acuity outcomes were compared between the pre-PnR (prior to the implementation; 110 eyes) and post-PnR (after the implementation; 112 eyes) periods, as well as between PnR and PPV in the post-PnR period. PARR for PnR was also evaluated based on RRD characteristics and gas injection frequency.</p><p><strong>Results: </strong>In the post-PnR period PnR was performed in 53.6% (60/112)of cases. The PARR was similar in the pre-PnR (97.3%) and post-PnR (93.8%) periods (P=.33). Visual outcomes were similar both across periods and between PnR and PPV at 3, 6 and 12 month post-operatively. The PARR for PnR was 88.3% overall, 90.5% in eyes meeting the Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT) criteria, 93.3% in eyes with a single break and 100% in eyes with a single break meeting PIVOT criteria. Eyes with a single gas injection had higher PARR than eyes requiring an additional gas injection (93.5% vs. 71.4%).</p><p><strong>Conclusion: </strong>Remote-learning utilizing social media effectively enabled PnR implementation with favorable anatomic and functional outcomes in a real-world setting in Japan.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-month comparative outcomes of aflibercept and faricimab in treatment-naïve macular edema secondary to branch retinal vein occlusion.","authors":"Taiichi Hikichi, Haruka Kurabe, Amane Notoya, Yuuna Oguro, Misaki Hirano, Yumeka Doi","doi":"10.1007/s10384-025-01254-8","DOIUrl":"https://doi.org/10.1007/s10384-025-01254-8","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the 6-month outcomes of aflibercept and faricimab in treatment-naïve macular edema secondary to branch retinal vein occlusion (BRVOME).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>The charts of consecutive treatment-naïve eyes with BRVOME treated with intravitreal injection therapy between December 2023 and August 2024 at Hikichi Eye Clinic (Sapporo, Japan) were reviewed; all eyes treated between December 2023 and April 2024 were administrated with aflibercept and all eyes treated between May 2024 and August 2024 were administrated with faricimab. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were assessed at baseline, 1, 3, and 6 months. Injection frequency and safety were also evaluated.</p><p><strong>Results: </strong>Fifty-four eyes (29 aflibercept, 25 faricimab) were included. Both groups showed significant improvement in BCVA (from 0.39 ± 0.29 to 0.09 ± 0.23) and CFT (from 617 ± 132 to 201 ± 68 µm) over 6 months (p < 0.001). The mean number of injections was significantly lower in the faricimab group (1.96 ± 0.68) than the aflibercept group (2.45 ± 0.87; p = 0.024). No serious adverse events were reported.</p><p><strong>Conclusion: </strong>Faricimab achieved similar visual and anatomical outcomes to aflibercept while requiring fewer injections, suggesting a potential advantage in reducing treatment burden.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive strabismus surgery versus conventional surgical technique for inferior oblique recessions.","authors":"Tushit Dhar, Subhash Dadeya, Vaishali Tomar, Shipra Sharda, Shivani Kumari","doi":"10.1007/s10384-025-01249-5","DOIUrl":"https://doi.org/10.1007/s10384-025-01249-5","url":null,"abstract":"<p><strong>Purpose: </strong>Minimally invasive strabismus surgery (MISS) employs keyhole incisions to expose muscles and perform surgery. MISS has been found to yield better cosmetic outcomes after surgery involving horizontal recti. To further these findings, our study compared MISS for inferior oblique (IO) recession with conventional approach, in terms of complications and functional outcomes.</p><p><strong>Study design: </strong>Prospective Interventional study METHODS: Forty adult patients with inferior oblique overaction (IOOA) were randomly divided into two groups-those undergoing recession by MISS and those by conventional technique. MISS involved making a small radial cut over IO insertion, while in the conventional group recession was done via larger conjunctival incision. Main Outcome Measures included conjunctival injection, chemosis, periorbital edema and residual IOOA recorded during the first six postoperative weeks. Patients were followed up at postoperative day 1, day 7 and 6 weeks.</p><p><strong>Results: </strong>The mean age of patients was 21.17±3.43 years. The average recession performed was 9.5±0.98 mm (conventional: 9.4±1.14 mm; MISS: 9.6±0.82 mm; p>0.05). Conjunctival congestion (p<0.05) and periorbital edema (p<0.01) were significantly less in MISS than in the conventional group. There was also a significant difference in chemosis on postoperative days one and seven (p=0.00015 & 0.035 respectively). However, both groups had similar appearance at week six. No significant difference was found for final alignment and residual IOOA.</p><p><strong>Conclusion: </strong>This study shows that the MISS technique is feasible for inferior oblique recessions. It seems to be particularly superior in the immediate postoperative period, due to fewer conjunctival and periorbital swelling complications. Long-term results did not differ between the two groups.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced plasma oxytocin levels in patients with open-angle glaucoma.","authors":"Yurina Yamada, Kota Sato, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Naoki Kiyota, Naoki Takahashi, Yoko Takeda, Chiaki Yamaguchi, Kazuko Omodaka, Toru Nakazawa","doi":"10.1007/s10384-025-01248-6","DOIUrl":"https://doi.org/10.1007/s10384-025-01248-6","url":null,"abstract":"<p><strong>Purpose: </strong>We explored the role of oxytocin in glaucoma by measuring the blood levels of oxytocin in glaucoma patients, comparing them to normal control subjects, and examining its association with clinical parameters.</p><p><strong>Study design: </strong>Retrospective cross-sectional study.</p><p><strong>Material and methods: </strong>After obtaining informed consent from 181 glaucoma patients and 44 age-matched control participants, we collected blood samples in ethylenediaminetetraacetic acid (EDTA) tubes and centrifuged them at 2000 g for 25 minutes at 4 °C. The resulting plasma was assayed for oxytocin concentration with an Enzyme Linked Immunosorbent Assay (ELISA) kit. We compared oxytocin concentrations in the control and glaucoma groups, and within the glaucoma group, we determined whether the oxytocin levels were correlated with mean deviation (MD) and sectoral total deviation (TD). Furthermore, in 33 patients who underwent at least five visual field tests over a two-year period following oxytocin measurements and received no surgical interventions during that time, we determined whether the oxytocin levels were correlated with MD slope and sectoral TD slopes.</p><p><strong>Results: </strong>Oxytocin levels in glaucoma patients were significantly lower than in age- and sex-matched normal controls (723.34 ± 303.44 vs. 557.59 ± 296.04 pg/ml, p=0.002). In glaucoma patients, oxytocin levels were significantly correlated with MD and inferior TD after adjustment for age and sex (β=0.149, p=0.041; β=0.156, p=0.034, respectively). There was a weak negative correlation between oxytocin concentration and MD slope (β=-0.334, p=0.084) and a weak negative correlation with central TD slope (β=-0.405, p=0.039), adjusted for age, sex, and history of additional eye drops.</p><p><strong>Conclusion: </strong>Oxytocin concentrations in glaucoma patients were significantly lower than in normal subjects and associated with the severity and progression of visual field defects. Given the wide variety of the pharmacological actions of oxytocin, it may be involved in the pathogenesis of glaucoma. Our results suggest that plasma oxytocin measurements may open a new avenue for glaucoma care.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loading phase outcomes of intravitreal aflibercept 8 mg for treatment-naïve neovascular age-related macular degeneration.","authors":"Hidetaka Matsumoto, Junki Hoshino, Saki Numaga, Yosuke Asatori, Hideo Akiyama","doi":"10.1007/s10384-025-01229-9","DOIUrl":"https://doi.org/10.1007/s10384-025-01229-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the efficacy and safety of loading phase treatment with 3 monthly intravitreal injections of aflibercept 8 mg for neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Retrospective, interventional case series.</p><p><strong>Methods: </strong>We retrospectively analyzed 83 consecutive eyes of 80 patients with treatment-naïve nAMD who received 3 monthly injections of aflibercept 8 mg as a loading phase treatment. Best-corrected visual acuity (BCVA), foveal thickness, central choroidal thickness (CCT), and dry macula achievement were all assessed every 4 weeks. Moreover, polypoidal lesion regression was evaluated after the loading phase.</p><p><strong>Results: </strong>Seventy eyes (84.3%) of 67 patients completed the 3 monthly injections of aflibercept 8 mg. In these cases, BCVA was 0.33±0.45 at baseline and showed significant improvement to 0.22±0.38 at week 12 (P<0.01). Foveal thickness was 313±135µm at baseline, decreasing significantly to 171±76µm at week 12 (P<0.01). CCT was 193±98µm at baseline, decreasing significantly to 160±85µm at week 12 (P<0.01). Dry macula had been achieved in 58 (82.9%) of 70 eyes at week 12. Indocyanine green angiography after the loading phase revealed complete polypoidal lesion regression in 16 of 22 eyes (72.7%) with polypoidal lesions. Among the 13 eyes (15.7%) not completing the loading phase treatment, 9 (10.8%) developed non-infectious intraocular inflammation (IOI) associated with retinal vasculitis and aflibercept 8 mg administration was thus discontinued.</p><p><strong>Conclusions: </strong>Loading phase treatment with intravitreal aflibercept 8 mg appears to be effective for improving visual acuity and ameliorating exudative changes in eyes with nAMD. However, careful monitoring is required due to the potential development of IOI associated with retinal vasculitis.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related difference in the presbyopia-correcting effect of trifocal and enhanced monofocal intraocular lenses.","authors":"Ken Hayashi, Koichi Uno, Shunsuke Hayashi, Motoaki Yoshida","doi":"10.1007/s10384-025-01245-9","DOIUrl":"https://doi.org/10.1007/s10384-025-01245-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare visual outcomes among three age groups in eyes with a trifocal (Alcon PanOptix^®) or enhanced monofocal intraocular lens (IOLs; Johnson & Johnson Eyhance^®).</p><p><strong>Study design: </strong>Nonrandomized comparative study.</p><p><strong>Methods: </strong>Seventy-eight eyes of 78 patients who received a trifocal IOL (trifocal category) and 78 eyes of 78 patients who received an enhanced monofocal IOL (enhanced monofocal category) were enrolled. Patients were stratified by age decade (n=26/group): 40-59 years of age (40s & 50s), 60-69 years of age (60s), and 70-79 years of age (70s). Uncorrected and distance-corrected visual acuity (VA) at various distances and photopic and mesopic contrast VA were examined at 3 months postoperatively and compared among age groups.</p><p><strong>Results: </strong>No significant differences in the mean uncorrected and distance-corrected VAs were detected at nearly all distances among the three age groups for either the trifocal or enhanced monofocal category. Mean photopic contrast VA was significantly different among the three age groups at 100% contrast for the trifocal category (P=0.018) and at 25%, 10%, 5%, and 2.5% contrasts in the enhanced monofocal category (P≤0.005); it was significantly better in the 40s & 50s age group than in the 60s or 70s age group (P≤0.002).</p><p><strong>Conclusion: </strong>All-distance VA in eyes with a trifocal IOL and an enhanced monofocal IOL was essentially comparable among patients 40-79 years of age although contrast sensitivity was significantly worse in older patients, suggesting that these IOLs can be implanted irrespective of patient age with careful consideration of the age-dependent decline in contrast sensitivity.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo characterization of morphologic changes in the lens during accommodation as a function of age by use of OCT with swept-source technology.","authors":"Mario Cantó-Cerdán, Ana Siverio-Colomina, Pilar Yébana-Rubio, Maria José García-Corral, Zaíra Cervera-Sánchez, Antonio Martínez-Abad","doi":"10.1007/s10384-025-01244-w","DOIUrl":"https://doi.org/10.1007/s10384-025-01244-w","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the in vivo morphologic and biometric changes in the lens during accommodation as a function of age by use of swept-source OCT technology STUDY DESIGN: Observational, prospective study METHODS: Complete optometric and ophthalmologic examinations were performed on all the patients to determine their eligibility for inclusion in the study. The examinations included anterior segment measurements obtained using swept-source OCT. Morphologic parameters of the lens were analysed under accommodative stimuli of 0, -1, -2, -3, and -6 D. A second measurement was taken 10 minutes after the first.</p><p><strong>Results: </strong>Three hundred eyes of 300 patients were enrolled in the study. Structural changes in the lens were observed, specifically in the anterior and posterior radii, which decreased with accommodation, and the total thickness of the lens, which increased. In patients aged younger than 40 years, significant changes were found in the curvature radius and lens thickness during accommodation. In patients aged older than 40 years, these changes began to diminish. Significant differences between stimuli (P <.05) were observed in all the groups, demonstrating lens variation during accommodation and its dependence on age. Repeatability analysis showed an intraclass correlation coefficient of >0.700 for all the parameters.</p><p><strong>Conclusions: </strong>During accommodation, the anterior and posterior curvatures of the lens decrease, while its thickness increases. Age-related differences remained significant, indicating persistent changes over time. Swept-source OCT demonstrated high repeatability, particularly for anterior curvature, thickness, and tilt, even under accommodation.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic nerve MRI findings in Leber's hereditary optic neuropathy.","authors":"Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1007/s10384-025-01246-8","DOIUrl":"https://doi.org/10.1007/s10384-025-01246-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the characteristics of magnetic resonance imaging (MRI) of lesions in Lebers hereditary optic neuropathy (LHON).</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>We examined the clinical characteristics and MRI scans of lesion locations in 34 LHON cases (68 eyes) with m.11778G>A mutation, examined within six months of onset who had detailed MRI imaging records available.</p><p><strong>Results: </strong>The median age was 36.5 (range: 10-75) years, with 26 male cases. MRI lesions were observed in 15 cases, with the following distribution: isolated intraorbital lesions in 7 cases, intraorbital + optic canal lesions in 1 case, intraorbital + optic canal + intracranial lesions in 1 case, optic canal + intracranial lesions in 1 case, optic canal + intracranial + chiasmal lesions in 1 case, intracranial + chiasmal lesions in 3 cases, and chiasmal + optic tract lesions in 1 case. There were no significant differences in clinical characteristics between patients with and without MRI lesions. Cases with chiasmal lesions tended to be younger (chiasmal lesion group [n=5] vs. non-chiasmal lesion group [n=29]: median age 25 [range: 11-30] years vs. 44 [range: 10-75] years, p=0.02, Mann-Whitney U test), although there were no significant differences in sex or time to MRI imaging.</p><p><strong>Conclusion: </strong>MRI lesions can extend from the intraorbital optic nerve to the chiasm and tract. Consistent with previous reports, chiasmal involvement was frequently observed and was more prevalent in younger patients. Recognition of these characteristic MRI and clinical findings is crucial in the differential diagnosis of subacute progressive optic neuropathy.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Heidelberg Multi-Color Anomaloskop with NEITZ anomaloscope OT-II to diagnose color-vision deficiency.","authors":"Kumiko Mokuno, Hiroki Kaneko, Hirotaka Ito, Hiroshi Takahashi, Tetsushi Yasuma","doi":"10.1007/s10384-025-01198-z","DOIUrl":"10.1007/s10384-025-01198-z","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the degree of agreement between the results of the Heidelberg Multi-Color Anomaloskop (HMC) and NEITZ anomaloscope OT-II (OT-II).</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Methods: </strong>The study included 53 patients who underwent color-vision testing at Kariya Toyota General Hospital between March 2019 and April 2022. The participants included 2 patients with normal color vision, 10 with protanopia, 3 with protanomaly, 22 with deuteranopia, and 16 with deuteranomaly. Color-vision testing was performed using the Ishihara Test for Colour Deficiency, Standard Pseudoisochromatic Plates Part 1, Farnsworth Dichotomous Test for Color Blindness Panel-15, HMC, and OT-II. An agreement was determined using intraclass correlation coefficients (ICC) and Bland-Altman analysis. The minimum, median, and maximum red-green mixture and yellow monochromatic values of the equal values obtained from HMC and OT-II were examined.</p><p><strong>Results: </strong>The ICCs between the results of HMC and OT-II were 0.979, 0.979, and 0.985, for the minimum, median, and maximum red-green mixture and 0.943, 0.755, and 0.919 for the yellow monochromatic values, respectively (p < 0.0001 in all). In the Bland-Altman analysis, the differences were mostly within the limits of agreement. Fixed errors were observed for the maximum red-green mixture and minimum yellow monochromatic values. Proportional errors were observed for the maximum red-green mixture and yellow monochromatic values.</p><p><strong>Conclusions: </strong>HMC and OT-II showed high agreement for all values in the ICC and Bland-Altman analyses. In the Bland-Altman analysis, systemic errors were observed in the maximum red-green mixture value and the minimum and maximum yellow monochromatic values.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"549-557"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features in four patients with syphilitic outer retinopathy.","authors":"Tomoyuki Oga, Kazuki Kuniyoshi, Akihiko Sugino, Tomoko Sato, Fukutaro Mano, Masuo Sakamoto, Chiharu Iwahashi, Koji Sugioka, Shunji Kusaka","doi":"10.1007/s10384-025-01191-6","DOIUrl":"10.1007/s10384-025-01191-6","url":null,"abstract":"<p><strong>Purpose: </strong>To present the clinical findings of patients diagnosed with syphilitic outer retinopathy.</p><p><strong>Study design: </strong>A retrospective clinical study.</p><p><strong>Patients and methods: </strong>The study involved four Japanese men whose medical charts were reviewed and analyzed retrospectively.</p><p><strong>Results: </strong>All patients declined decimal visual acuity to 0.1, 0.2, 0.4, 0.6, and 0.8. Their fundus appearances were generally normal, except for one patient who displayed faint white dots in the upper macular region. Two patients showed dye leakage from retinal vessels during fluorescein angiography. Optical coherence tomography (OCT) results revealed abnormalities in all patients: three had a disrupted ellipsoid zone (EZ) and hyper-reflective nodules at the retinal pigment epithelium line, while one patient presented with a blurred EZ. The patients had myopia ranging from -4.5 to -7.5 diopters. They were diagnosed with syphilitic outer retinopathy based on the findings from the fundus examination, OCT, and serologic tests and were treated with oral amoxicillin, resulting in improved vision.</p><p><strong>Conclusions: </strong>The OCT findings are typical for diagnosing syphilitic outer retinopathy. Myopia was prevalent in the four patients, indicating a need for further research on refractive errors in patients with syphilitic outer retinopathy.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"512-520"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}