Japanese Journal of Ophthalmology最新文献

{"title":"Retinal displacement using optical coherence tomography angiography and metamorphopsia in eyes undergoing macular hole surgery.","authors":"Shun Tsukahara, Asuka Takeyama, Masahiro Ishida","doi":"10.1007/s10384-025-01176-5","DOIUrl":"10.1007/s10384-025-01176-5","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between metamorphopsia and retinal structural changes using optical coherence tomography angiography (OCTA) images before and after macular hole (MH) surgery.</p><p><strong>Study design: </strong>Retrospective, consecutive, case series.</p><p><strong>Methods: </strong>Twenty-seven eyes of 27 patients undergoing MH surgery with internal limiting membrane peeling were studied. M-CHARTS (MC) was used to evaluate metamorphopsia. Retinal distances were measured between two sets of retinal vessel bifurcations that cross the macula vertically and horizontally near and distal to the macula using OCTA 3x3 mm en face images. The rate of change in retinal distance was defined as retinal displacement%. Basal and minimum MH diameters and retinal thicknesses were measured using Spectralis.</p><p><strong>Results: </strong>The vertical and horizontal MC scores improved postoperatively (P<0.001). The retinal distance decreased in all periods (P<0.001), and retinal displacements% was greater near than distal to the center of the macula (P<0.001). Retinal displacement% was correlated with basal MH diameter (r_s=-0.419 to -0.280, P<0.001 to 0.045). The horizontal MH diameter was a significant factor related to vertical MC score at baseline and 6 months postoperatively (P value range: P=0.002-0.004). The rates of change in outer retinal thickness and retinal displacement% near the center of the macula were significant factors related to horizontal MC scores at 6 months (P<0.001).</p><p><strong>Conclusion: </strong>Retinal displacement near the macular region contributes to MH closure after surgery. The larger the MH diameter, the greater the retinal displacement near the macula and the degree of residual postoperative metamorphopsia.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"395-402"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of porcine and human aqueous humor outflow tract anatomies with transparency enhancement.","authors":"Yuichi Asahina, Makoto Aihara, Takashi Miyai, Asami Tanaka, Hiroshi Onodera","doi":"10.1007/s10384-024-01151-6","DOIUrl":"10.1007/s10384-024-01151-6","url":null,"abstract":"<p><strong>Purpose: </strong>There is no established method for visualizing the three-dimensional (3D) structure of the aqueous humor outflow tract. This study attempted to visualize the 3D structures of porcine and human ocular tissues, particularly the aqueous humor outflow tract using a transparency reagent composed of 2, 2-thiodiethanol.</p><p><strong>Study design: </strong>Clinical and experimental.</p><p><strong>Methods: </strong>The porcine eyes were collected in Japan, and the human eyes were imported from the United States. The human eyes were obtained from a 64-year-old Caucasian woman, arriving 7 days after her death. The specimens were formalin-fixed upon arrival, fluorescently labeled, optically cleared using a transparency-enhancing reagent, and visualized using a confocal microscope.</p><p><strong>Results: </strong>Both porcine and human eyes were visualized to the extent that the choroidal vessels were observed on gross examination. The aqueous humor outflow tract was clearly observed as a luminal structure in the porcine eye, mainly depicted by autofluorescence, and in the human eyes as a luminal structure continuing from the trabecular meshwork without fluorescence.</p><p><strong>Conclusion: </strong>Observations using transparency-enhancing technology enabled us to obtain 3D images useful for visualizing ocular tissues, especially the aqueous humor outflow tract.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"460-468"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and structural analysis of pathogenic variants in MYOC and CYP1B1 genes in Indian JOAG patients.","authors":"Manoj Yadav, Mukesh Kumar, Chand Singh Dhull, Sumit Sachdeva, Aarti Bhardwaj, Anshu Yadav, Vishal Panghal, Pradeep Sharma, Ankit Kumari, Ritu Yadav, Mayank Singh, Rakesh Kumar, Anupama Deora, Manisha Rathi, Punit Kaur, Mukesh Tanwar","doi":"10.1007/s10384-025-01173-8","DOIUrl":"10.1007/s10384-025-01173-8","url":null,"abstract":"<p><strong>Purpose: </strong>Juvenile onset open-angle glaucoma (JOAG) manifests in individuals under the age of 40, resulting in elevated intraocular pressure and significant optic nerve damage. To broaden the spectrum of mutations associated with JOAG and to determine their specific structural implications, we examined Myocilin and Cytochrome P450 1B1 gene in a cohort of 111 unrelated North Indian patients diagnosed with JOAG.</p><p><strong>Study design: </strong>A clinical and experimental study.</p><p><strong>Methods: </strong>PCR-DNA sequencing screened the coding exons and intron-exon junctions of the MYOC and CYP1B1 genes in 111 unrelated JOAG patients and 100 controls. Identified sequence variations were searched in the ClinVar database, HGMD, and dbSNP. Six different online available algorithms including rare exome variant ensemble learner (REVEL), Sorting Intolerant From Tolerant (SIFT), Mutation Taster, SNAP2, IMutant2.0, and MutPred2 were used for the pathogenicity prediction of missense variations. The Structural consequences of detected possible pathogenic variations were predicted by using PyMol, Chimera and MD simulation of these changes.</p><p><strong>Results: </strong>Potentially-pathogenic variations were observed in thirty patients (27.02%) within the MYOC and CYP1B1 genes, encompassing both novel and previously documented variants. Structural predictions of novel potentially-pathogenic mutations indicate altered stability and flexibility.</p><p><strong>Conclusion: </strong>Analysis reveals a higher prevalence of CYP1B1 gene variants (22.5%) relative to MYOC gene variants (4.5%), suggesting that CYP1B1 is the predominant gene implicated in JOAG among Indian patients. Our findings enhance the understanding of mutation spectra and frequencies of MYOC and CYP1B1gene in JOAG among the North Indian population. Structural predictions of novel pathogenic mutations could enhance the understanding of JOAG pathogenesis and support subsequent functional analysis.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"469-481"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Fourier harmonic analysis in prostaglandin-associated periorbitopathy patients with blepharoptosis.","authors":"Tatsuya Yunoki, Yuto Uozumi, Naoki Tojo, Mitsuya Otsuka, Atsushi Hayashi","doi":"10.1007/s10384-025-01177-4","DOIUrl":"10.1007/s10384-025-01177-4","url":null,"abstract":"<p><strong>Purpose: </strong>Prostaglandin-associated periorbitopathy (PAP), which causes skin hardening, ptosis, and deepening of the upper eyelid sulcus (DUES), has been suggested to affect corneal shape due to increased eyelid pressure. In this study, we performed a corneal shape analysis using anterior segment optical coherence tomography (AS-OCT) in patients with PAP accompanied by blepharoptosis.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>Fourier harmonic corneal shape analysis using anterior segment OCT was performed in patients with a margin reflex distance-1 (MRD-1) of 2 mm or less (176 eyes of 101 cases). Cases with congenital ptosis, neurogenic ptosis, facial nerve palsy, thyroid eye disease, history of eyelid surgery, vitrectomy, glaucoma tube shunt surgery or filtration surgery were excluded. Patients were divided into two groups based on the presence or absence of prostaglandin analog (PGA) eye drops, and a comparative analysis was conducted.</p><p><strong>Results: </strong>In the comparison between the PGAs group (n=47) and the non-PGAs group (n=129), no significant differences were observed in age, gender, MRD-1, or levator function. However, the PGAs group exhibited significantly larger values for both regular and irregular astigmatism. Additionally, in the PGAs group, when the severity of PAP was classified (grades 0 to 3), there was a correlation between PAP grade and both regular and irregular astigmatism.</p><p><strong>Conclusion: </strong>Patients with PAP who developed ptosis exhibited significant increases in both regular and irregular astigmatism, with a correlation observed between PAP grade and astigmatism. It is suggested that the increased eyelid pressure due to PAP may influence corneal shape.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"360-364"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriologic profile and antimicrobial resistance in infants aged 1 year or younger with congenital nasolacrimal duct obstruction.","authors":"Zhansaya Sultanbayeva, Botagoz Issergepova, Aida Kapanova, Kairat Ruslanuly","doi":"10.1007/s10384-025-01197-0","DOIUrl":"10.1007/s10384-025-01197-0","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to evaluate conjunctival flora and antibiotic susceptibility in infants aged 1 year or younger with congenital nasolacrimal duct obstruction (CNLDO), creating an overall profile of antimicrobial susceptibility.</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Methods: </strong>The analysis was conducted at the Kazakh Eye Research Institute over a period of 6 years, from January 2017 to December 2022. Cultures were grown on various agars for bacterial and fungal analyses, with sensitivity testing via Vitek 2 Compact.</p><p><strong>Results: </strong>We examined 1210 conjunctival cultures from infants with CNLDO, yielding 1212 isolates. Most were gram-positive bacteria (77.15%), with fewer gram-negative bacteria (22.28%) and fungi (0.57%). Among the gram-positive bacteria, Staphylococcus species (61.06%) were predominant, including S epidermidis (17.49%), S aureus (10.73%), and S saprophyticus (9.32%). Enterococcus species (6.52%) and Streptococcus species (6.02%) followed. Among the gram-negative bacteria, Escherichia coli (5.78%) was most prevalent, followed by Pseudomonas species. (4.54%), Enterobacter cloacae (3.71%), and Klebsiella species (3.63%). The majority of the fungi were Candida albicans, accounting for 4 isolates (0.33%). Most of the bacteria showed high sensitivity to moxifloxacin (92.52%), levofloxacin (88.99%), gentamicin (86.74%), vancomycin (86.52%), cefotaxime (85.27%), and ofloxacin (85.62%). High resistance was noted for erythromycin (32.84%), clindamycin (28.13%), and tetracycline (21.65%).</p><p><strong>Conclusion: </strong>In this study, we identified Staphylococcus, Enterococcus, and Streptococcus species and E coli as key CNLDO bacteria and highly responsive to antibiotics like levofloxacin and moxifloxacin. These findings guide effective antibiotic choices for CNLDO treatment, aiding in the prevention of antibiotic resistance.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"442-446"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of axial length measurement method for eyes with submacular hemorrhage.","authors":"Masakazu Nagayama, Shuhei Kimura, Mio Morizane Hosokawa, Yusuke Shiode, Ryo Matoba, Tetsuro Morita, Keisuke Kanenaga, Yuki Morizane","doi":"10.1007/s10384-024-01147-2","DOIUrl":"10.1007/s10384-024-01147-2","url":null,"abstract":"<p><strong>Purpose: </strong>To identify a method for comparing preoperative axial length (AL) measurements with postoperative AL in submacular hemorrhage (SMH).</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Methods: </strong>This study included 30 patients who underwent vitrectomy for SMH (January 2016-January 2023) with preoperative and postoperative AL data. Preoperative AL was obtained using ultrasonography for the affected eye (aUS-AL) and compared to those measured using optical biometry (OB) for the affected and fellow eyes (aOB-AL and fOB-AL, respectively). Postoperative AL (aPost-AL) was defined as the AL of the affected eye by OB. The absolute differences between the preoperative AL (aUS-AL, aOB-AL, and fOB-AL) and aPost-AL were assessed.</p><p><strong>Results: </strong>aUS-AL, aOB-AL, and fOB-AL values were 23.50 ± 1.41 mm, 23.32 ± 1.40 mm, and 23.66 ± 1.45 mm, respectively, correlating strongly with aPost-AL (23.54 ± 1.37 mm) (all R > 0.95). fOB-AL exceeded aPost-AL significantly (P = 0.02). In all 30 eyes, absolute differences between preoperative AL and aPost-AL were 0.19 ± 0.18 mm, 0.28 ± 0.32 mm, and 0.21 ± 0.22 mm, respectively, which were not significantly different from each other (all P > 0.05). In nine eyes with SMH height > 1000 μm or unmeasurable, the absolute difference between aOB-AL and aPost-AL (0.42 ± 0.33 mm) exceeded that of aUS-AL and aPost-AL (0.10 ± 0.09 mm) (P = 0.003).</p><p><strong>Conclusion: </strong>Although aUS-AL, aOB-AL, and fOB-AL correlated well with postoperative AL in patients with SMH, fOB-AL may be measured longer and aOB-AL shorter in some cases. Therefore, aUS-AL may be considered primarily in determining IOL power of cataract surgery performed in combination with SMH displacement.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"196-202"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year randomized controlled trial of circumferential versus segmental ab externo angle surgery in patients with primary open angle glaucoma.","authors":"Ahmed Samy Elwehidy, Nader Hussein Lotfy Bayoumi, Mostafa A S Elwehidy, Nashaat Shawky Zaky, Sherein M Hagras, Nader H L Bayoumi","doi":"10.1007/s10384-024-01150-7","DOIUrl":"10.1007/s10384-024-01150-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the surgical outcomes of visco-circumferential-suture-trabeculotomy (VCST) and rigid probe segmental viscotrabeculotomy (VT) in primary open-angle glaucoma (POAG).</p><p><strong>Study design: </strong>A prospective randomized controlled study.</p><p><strong>Patients and methods: </strong>Patients presenting with POAG and operated upon in Mansoura Ophthalmic Center in Mansoura, Egypt between February 2017 and September 2021 were enrolled. Study eyes were randomized to either VCST or VT and follow up extended for 24 months. Success was defined as an intra ocular pressure (IOP)≤18 mmHg with a 40% reduction from baseline. Complications were noted.</p><p><strong>Results: </strong>The study enrolled 166 (82 in the circumferential group) eyes of 107 patients. There were no statistically significant differences between both groups in any demographic or preoperative clinical characteristics. The IOP trend demonstrated marked initial reduction (from 32.3±2.4 and 31.8±2.6 mmHg preoperatively in VCST and VT groups respectively) followed by a slow gradual rise over subsequent follow-up settling at lower IOP values in the circumferential (12.4±1.2 mmHg) than in the segmental group (15.5±0.9 mmHg) (p<0.001), both settling at significantly lower levels than preoperative values. The survival curve demonstrates complete success rates at 12, 15, 18, and 24 months were 98.8%, 96.4%, 95.1%, and 85.4% in the circumferential group and 98.8%, 92.9%, 91.7%, 79.8% in the segmental group respectively. Minimal self-limiting hyphema was universal in all study eyes.</p><p><strong>Conclusions: </strong>Angle procedures -segmental and circumferential- are effective in lowering the IOP for at least 2 years in eyes with POAG, with circumferential angle surgery providing a greater reduction of IOP and requiring fewer subsequent glaucoma procedures.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"279-286"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and aesthetic outcomes of silicone buckles as an implant for anophthalmic sockets: a decade of experience in Japan.","authors":"Rikako Iwasaki, Yoshiyuki Kitaguchi, Takeshi Morimoto, Hiroshi Shimojo, Takahiro Fujino, Shimpei Komoto, Kohji Nishida","doi":"10.1007/s10384-025-01164-9","DOIUrl":"10.1007/s10384-025-01164-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the safety and aesthetic outcomes of silicone buckle #506 for anophthalmic socket reconstruction.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>Patients who underwent enucleation or evisceration at the Osaka University Hospital were retrospectively analyzed. Patients under 18 years old, with < 3 months follow-up, without a prosthesis, or with bilateral surgery were excluded. Aesthetic outcomes were assessed using standardized photographs taken 3 months postoperatively, scored by five independent ophthalmologists for upper eyelid sulcus deepening asymmetry. Scoring was categorized as 0: no noticeable side difference, 1: slight asymmetry, and 2: marked asymmetry characterized by upper eyelid sulcus deepening.</p><p><strong>Results: </strong>Fifty-nine patients (60 sockets) were analyzed. Thirty-three received silicone buckle implants (1-4 buckles). Implant exposure occurred in two patients (6.1%). Aesthetic scores were assessed in 48 patients. Mean aesthetic scores were 0.97 (no implant), 0.78 (one buckle), 0.68 (two buckles), and 0.42 (three/four buckles) (p = 0.123).</p><p><strong>Conclusions: </strong>Silicone buckle #506 appears to be a safe and feasible option for anophthalmic socket reconstruction. Further studies are needed to optimize aesthetic outcomes and determine the ideal number of buckles.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"214-220"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of ROH-101 (0.15% ganciclovir gel) for cytomegalovirus corneal endotheliitis: an open-label, uncontrolled, phase 3 study in Japan.","authors":"Noriko Koizumi, Dai Miyazaki, Seiichiro Sugita, Chie Sotozono, Tsutomu Inatomi, Hiroshi Goto, Atsushi Shiraishi, Shuichiro Eguchi, Shin-Ichiro Ito, Yuichi Hori, Eiichi Uchio, Takeshi Soma, Takeo Fukuchi, Ken Hayashi, Yusuke Takeuchi, Yoshitsugu Inoue","doi":"10.1007/s10384-025-01168-5","DOIUrl":"10.1007/s10384-025-01168-5","url":null,"abstract":"<p><strong>Purpose: </strong>Cytomegalovirus (CMV) corneal endotheliitis often causes severe visual impairment owing to irreversible corneal endothelial dysfunction. Given the side effects of systemic antiviral therapy, development of an approved topical antiviral agent for CMV corneal endotheliitis is desirable. This study evaluated the efficacy and safety of topical 0.15% GCV gel, ROH-101, in the treatment of CMV corneal endotheliitis in Japanese patients.</p><p><strong>Study design: </strong>Open-label, multicenter, uncontrolled, phase 3 study (jRCT2051210064).</p><p><strong>Methods: </strong>The study was conducted from August 2021 to December 2022, with a 2-week run-in period with 0.1% fluorometholone eye drops alone, a 12-week treatment period with additional ROH-101, and a 24-week post-treatment observation period after discontinuation of ROH-101. The primary endpoint was the proportion of patients achieving a CMV DNA copy number in the aqueous humor of less than 10³ copies/mL at week 12. The clinical findings and safety were assessed over the treatment and post-treatment observation periods.</p><p><strong>Results: </strong>Twelve eyes of 12 patients with PCR-proven CMV corneal endotheliitis were enrolled. Treatment was discontinued in 1 eye owing to an adverse event. The other 11 eyes completed 12 weeks of treatment with 63.6% achieving the primary endpoint. The clinical findings, such as corneal edema, coin-shaped lesions, and anterior chamber inflammation, improved in all 11 eyes and did not worsen in 8 eyes that completed the post-treatment observation period. Endothelial cell density was well maintained, and none of the 11 eyes showed corneal endothelial dysfunction. Mild adverse drug reactions were reported in 3 eyes (8.3%).</p><p><strong>Conclusion: </strong>ROH-101 was a safe and efficacious treatment in Japanese patients diagnosed with CMV corneal endotheliitis.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"296-307"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous retina transplantation for refractory highly myopic macular holes: a long-term follow-up.","authors":"Matteo Mario Carlà, Carlos Mateo","doi":"10.1007/s10384-025-01169-4","DOIUrl":"10.1007/s10384-025-01169-4","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate long-term anatomical and functional outcomes of autologous retinal transplantation (ART) in refractory highly myopic macular holes (HMMHs).</p><p><strong>Study design: </strong>Retrospective interventional analysis of 9 eyes with refractory HMMH undergoing ART.</p><p><strong>Methods: </strong>Best-corrected visual acuity (BCVA, Snellen) and optical coherence tomography (OCT) were performed at baseline and each follow-up visit (1, 3, 6, 12, 24 months and the most recent). Preoperatively, we collected minimum linear diameter (MLD) and basal diameter (BD). Post-operatively, central macular thickness (CMT), external limiting membrane (ELM)/ellipsoid zone (EZ) visibility, macular edema (ME) and retinal pigmented epithelium (RPE) atrophy were evaluated.</p><p><strong>Results: </strong>Mean follow-up duration was 46.0 ± 19.6 months. Anatomical success was reached in 7/9 eyes (78%). Median BCVA went from 0.05 (IQR 0.065) at baseline to 0.075 (IQR 0.069) at final follow-up (p = 0.25). Only one eye showed a 2-lines improvement, while BCVA was stable in 4/9 (44%) and worsened in 1 eye (12%). CMT progressively thickened in the first 6 months (177 ± 68 μm), but then decreased to 122 ± 50 μm at final follow-up. Graft merging with the surrounding retina was visible in two eyes, showing partial ELM/EZ recovery and good outcomes. Microcystic-like refractory ME (33%) and long-term RPE atrophy (22%) were reported, while delayed displacement of the graft was seen in one case 6 months after first surgery.</p><p><strong>Conclusion: </strong>ART offered acceptable anatomical success but no visual improvement in our cohort. Lack of graft merging with the surrounding retina, persistent microcystic-like ME, RPE atrophy and hole recurrence were the most frequent shortfalls.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"259-267"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}