Japanese Journal of Ophthalmology最新文献_第9页

Association between fundus sex index and hypertension, diabetes mellitus, and smoking in the Kumejima study. Kumejima研究中眼底性别指数与高血压、糖尿病和吸烟的关系。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-03-04 DOI: 10.1007/s10384-026-01334-3

Takehiro Yamashita, Ryo Asaoka, Aiko Iwase, Hiroshi Sakai, Hiroto Terasaki, Taiji Sakamoto, Makoto Araie

{"title":"Association between fundus sex index and hypertension, diabetes mellitus, and smoking in the Kumejima study.","authors":"Takehiro Yamashita, Ryo Asaoka, Aiko Iwase, Hiroshi Sakai, Hiroto Terasaki, Taiji Sakamoto, Makoto Araie","doi":"10.1007/s10384-026-01334-3","DOIUrl":"10.1007/s10384-026-01334-3","url":null,"abstract":"Purpose: Fundus parameters can be used to quantify masculinity or femininity as a fundus sex index (FSI) ranging from 0 to 1. The purpose of this study was to investigate the association between smoking, hypertension, diabetes, and FSI in the Kumejima population study STUDY DESIGN: Prospective cross-sectional observational population study METHODS: Using color fundus photographs obtained from the Kumejima population study, 1653 healthy right eyes with reliable fundus parameter measurements were included. The tessellation fundus index R/(R + G + B), red-green-blue intensity in eight locations around the optic disc and foveal region, optic disc ovality ratio, papillomacular angle, and retinal vessel angles were quantified using ImageJ. The FSI was calculated using machine learning from the 42 fundus parameters, and the Mann-Whitney U-test was used to assess whether there were differences in the FSI depending on the presence or absence of smoking, hypertension, and diabetes RESULTS: The mean age of the 838 men and 815 women included in this study was 52.8 and 54.0 years, respectively. The FSI of the smoking group was lower than of the non-smoking group overall (P < 0.001). The FSI of the hypertension and diabetes groups was significantly higher than of the non-hypertension (P = 0.005) and non-diabetes (P = 0.017) groups only in women CONCLUSION: In the Kumejima population study of healthy eyes in individuals aged 40 years or older, the fundus tended to be more feminine in women with hypertension or diabetes than in those without these conditions.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"991-997"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-widefield indocyanine green angiography findings of vortex veins in central serous chorioretinopathy. 中央浆液性脉络膜视网膜病变漩涡静脉的超宽视场吲哚菁绿血管造影表现。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-03-19 DOI: 10.1007/s10384-026-01342-3

Akiyuki Kawamura, Ryusaburo Mori, Ruri Sugiyama, Koji Tanaka, Hajime Onoe, Yu Wakatsuki, Ayaka Nakai, Keigo Takeshima, Norihiro Tsuchiya, Hiroyuki Nakashizuka

{"title":"Ultra-widefield indocyanine green angiography findings of vortex veins in central serous chorioretinopathy.","authors":"Akiyuki Kawamura, Ryusaburo Mori, Ruri Sugiyama, Koji Tanaka, Hajime Onoe, Yu Wakatsuki, Ayaka Nakai, Keigo Takeshima, Norihiro Tsuchiya, Hiroyuki Nakashizuka","doi":"10.1007/s10384-026-01342-3","DOIUrl":"10.1007/s10384-026-01342-3","url":null,"abstract":"Purpose: To characterize choroidal circulation in the vortex veins in central serous chorioretinopathy.Study design: Single-center retrospective study.Methods: The study included 22 eyes with central serous chorioretinopathy from 22 patients with serous retinal detachment at the macula (18 men and four women, mean age 47.3 years). Ultra-widefield indocyanine green angiography was performed using Optos®California, and images were taken intermittently from the early to the late phase (> 20 min of contrast) to examine late images of the vortex veins. Findings in the affected and contralateral eyes were also compared.Results: In 13 of the 22 eyes, the vortex veins were hypofluorescent in all quadrants and continuous with the vortex ampullae. In five eyes, only the asymmetric dilated vortex vein was hypofluorescent, and in four eyes, the vortex veins were not hypofluorescent. Of the 22 contralateral eyes examined, 20 eyes exhibited identical findings in the vortex veins to those observed in the affected eye. Of the four eyes that did not exhibit hypofluorescence of the vortex veins in the affected eye, two eyes had partial hypofluorescence of some vortex veins in the contralateral eye, showing different findings.Conclusions: In the late phase, some eyes showed hypofluorescence due to the washout of indocyanine green dye in the vortex veins and others did not, suggesting that obstruction of the scleral passage in the choroidal venous outflow is not the main cause of the syndrome.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"835-842"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of micropulse cyclophotocoagulation for refractory glaucoma in children. 微脉冲光凝治疗儿童难治性青光眼的疗效。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-04-16 DOI: 10.1007/s10384-026-01354-z

Tomoyo Yoshida, Tadashi Yokoi, Hazuki Anzai, Ayaka Nishida, Sachiko Nishina

{"title":"Outcomes of micropulse cyclophotocoagulation for refractory glaucoma in children.","authors":"Tomoyo Yoshida, Tadashi Yokoi, Hazuki Anzai, Ayaka Nishida, Sachiko Nishina","doi":"10.1007/s10384-026-01354-z","DOIUrl":"10.1007/s10384-026-01354-z","url":null,"abstract":"Purpose: To evaluate the outcomes of micropulse transscleral cyclophotocoagulation (MP-CPC) for refractory glaucoma in children.Study design: Retrospective study.Methods: We evaluated the data from children with refractory glaucoma who underwent MP-CPC from July 2022 to December 2024 at the National Center for Child Health and Development and who were followed up for at least 3 months. The retrospective analysis included age; glaucoma type; history of glaucoma surgery; intraocular pressure (IOP) at baseline and at 1, 3, and 6 months postoperatively; medication score administered before and after surgery; visual acuity; and complications.Results: Twenty-nine eyes of 24 patients (average age, 101.3 ± 68.1 months) were included in this study. The most common types of glaucoma were glaucoma associated with nonacquired ocular anomalies and glaucoma after cataract surgery, accounting for 11 eyes (37.9%). The average number of glaucoma surgeries performed before treatment was 1.9 ± 1.6. The average follow-up period was 16.1 ± 7.9 months. Using a mixed-effects model, the mean IOP decreased by -9.8 mm Hg at 1 month (P <.01), -7.5 mm Hg at 3 months (P <.01), and -7.4 mm Hg at 6 months (P <.01). The median medication score (interquartile range) decreased from 5 (4-6) preoperatively to 4 (3-5) at 1, 3, and 6 months postoperatively. After undergoing the first MP-CPC, 19 eyes (65.5%) required reoperation for glaucoma. Eleven eyes (37.9%) required reoperation within 6 months postoperatively, and 17 eyes (58.6%) required reoperation within 1 year.Conclusion: MP-CPC effectively reduces IOP in children with refractory glaucoma without causing visual impairment or serious complications.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"765-772"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term safety and efficacy of sepetaprost, with or without timolol, in patients with open-angle glaucoma or ocular hypertension: results from the randomised, phase 3 ANGEL-J2 study. sepetaprost联合或不联合替莫洛尔治疗开角型青光眼或高眼压患者的长期安全性和有效性：来自随机3期ANGEL-J2研究的结果

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-06-16 DOI: 10.1007/s10384-026-01351-2

Masaru Inatani, Yuko Tone, Toshihiro Ikeda, Raymund Angeles

{"title":"Long-term safety and efficacy of sepetaprost, with or without timolol, in patients with open-angle glaucoma or ocular hypertension: results from the randomised, phase 3 ANGEL-J2 study.","authors":"Masaru Inatani, Yuko Tone, Toshihiro Ikeda, Raymund Angeles","doi":"10.1007/s10384-026-01351-2","DOIUrl":"10.1007/s10384-026-01351-2","url":null,"abstract":"Purpose: To evaluate the long-term safety and intraocular pressure (IOP)-lowering efficacy of sepetaprost, a novel dual FP/EP3 receptor agonist, in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).Study design: ANGEL-J2 (NCT05503901) was a phase 3, randomised, parallel-group, open-label study across 20 sites in Japan.Methods: Adult patients with IOP ≥16 and <22 mmHg were assigned to once-daily sepetaprost 0.002% (Group 1), whereas patients with IOP ≥22 and ≤34 mmHg were randomised 1:1 to once-daily sepetaprost 0.002% alone (Group 2) and with twice-daily timolol 0.5% (Group 3). Over 52 weeks of treatment, efficacy was assessed as the change in mean diurnal IOP from baseline; safety outcomes included the incidence of adverse drug reactions (ADRs).Results: In total, 131 patients were assigned to Group 1 (n=49), Group 2 (n=42), or Group 3 (n=40). In each group, treatment was associated with rapid and sustained reductions in IOP versus baseline (p<0.0001 at all time-points). Mean (± standard error) change in diurnal IOP from baseline at week 52 was -4.40±0.24, -6.38±0.32, and -7.51±0.29 mmHg in Groups 1, 2, and 3, respectively; similarly, mixed model for repeated measures analyses found that reductions in mean diurnal IOP over 52 weeks were greater in Group 3 versus Group 2. ADRs were reported in 80 patients overall (59.2-65.0% across groups), most commonly mild eyelash growth (22.4-42.5%) and mild conjunctival hyperaemia (28.6-30.6%).Conclusion: Sepetaprost, with or without timolol, demonstrated good tolerability and may represent an efficacious long-term treatment option for OAG or OHT.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"940-948"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrotic response after Baerveldt glaucoma drainage device surgery: an initial sight-threatening sign in eyes with refractory childhood glaucoma. Baerveldt青光眼引流装置手术后的纤维化反应：难治性儿童青光眼的初始视力威胁体征。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-05-02 DOI: 10.1007/s10384-026-01357-w

Rumi Kawashima, Kenji Matsushita, Masako Kurashige, Takahiro Matsui, Yuichi Motoyama, Takahiro Fujino, Eiichi Morii, Kohji Nishida

{"title":"Fibrotic response after Baerveldt glaucoma drainage device surgery: an initial sight-threatening sign in eyes with refractory childhood glaucoma.","authors":"Rumi Kawashima, Kenji Matsushita, Masako Kurashige, Takahiro Matsui, Yuichi Motoyama, Takahiro Fujino, Eiichi Morii, Kohji Nishida","doi":"10.1007/s10384-026-01357-w","DOIUrl":"10.1007/s10384-026-01357-w","url":null,"abstract":"Purpose: We report the pathological analysis of a postoperative fibrotic reaction as an initial sign of a sight-threatening complication observed during the 2-year outcomes follow up of Baerveldt glaucoma implant (BGI) surgery in eyes with refractory childhood glaucoma.Study design: Retrospective case series.Methods: Fifteen eyes of 10 patients with refractory childhood glaucoma underwent BGI surgery between 2013 and 2020 at the University of Osaka Hospital. Patients were followed for a minimum of 2 years postoperatively. We investigated the postoperative complications, and histopathologically analyzed the specimens obtained from three eyes with postoperative fibrous membranes on the irises.Results: Nine eyes (60%) had a postoperative fibrous membrane around the tube or on the iris close to the tube, whereas two eyes developed a tractional retinal detachment. The pathological results indicated the tissues were eosinophilic fibrous scar tissues that did not have inflammatory or neoplastic lesions.Conclusion: BGI surgery was effective in patients with refractory childhood glaucoma. However, clinicians should be alert to the potential for development of fibrotic ocular inflammation in refractory childhood glaucoma eyes.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"923-930"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal changes in retinal nerve fiber layer thickness after vitrectomy for vitreomacular traction syndrome. 玻璃体切除治疗玻璃体黄斑牵引综合征后视网膜神经纤维层厚度的纵向变化。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-03-31 DOI: 10.1007/s10384-026-01346-z

Gee-Hyun Kim, Young-Geun Park, Young-Hoon Park

{"title":"Longitudinal changes in retinal nerve fiber layer thickness after vitrectomy for vitreomacular traction syndrome.","authors":"Gee-Hyun Kim, Young-Geun Park, Young-Hoon Park","doi":"10.1007/s10384-026-01346-z","DOIUrl":"10.1007/s10384-026-01346-z","url":null,"abstract":"Purpose: To investigate long-term changes in peripapillary retinal nerve fiber layer thickness (RNFLT) after surgery for vitreomacular traction syndrome (VMTS), and to identify prognostic factors for surgical outcomes.Study design: Retrospective chart review.Methods: This retrospective study included 34 eyes from 34 patients with unilateral VMTS who underwent pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling and completed a 12-month follow-up. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and peripapillary RNFLT were measured at baseline and at 1, 3, 6, and 12 months postoperatively using swept-source optical coherence tomography (OCT). Longitudinal changes and baseline predictors of visual outcomes were analyzed.Results: BCVA improved significantly from 3 months postoperatively (P < 0.001), while CMT reduction was evident from 1 month (P < 0.001). RNFLT progressively decreased across all quadrants, with early thinning in the inferior sector (P = 0.014). Compared with fellow eyes, operated eyes showed greater temporal RNFLT preoperatively but thinner global and inferior RNFLT at 12 months. Better postoperative BCVA correlated with better baseline BCVA, thinner preoperative CMT, and thicker preoperative inferior RNFLT, although baseline BCVA was the strongest independent predictor.Conclusions: VMTS eyes demonstrated progressive RNFLT thinning after surgery, reflecting both resolution of vitreous traction and underlying neuronal vulnerability. Baseline BCVA was the most reliable prognostic factor, while CMT and inferior RNFLT may provide additional insights into surgical outcomes.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"886-896"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of visual performance between three enhanced monofocal intraocular lenses under different refractive targets. 不同屈光目标下三种增强单焦点人工晶体视觉性能的比较。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-03-04 DOI: 10.1007/s10384-026-01339-y

Hisaharu Suzuki, Miho Nishiyama

{"title":"Comparison of visual performance between three enhanced monofocal intraocular lenses under different refractive targets.","authors":"Hisaharu Suzuki, Miho Nishiyama","doi":"10.1007/s10384-026-01339-y","DOIUrl":"10.1007/s10384-026-01339-y","url":null,"abstract":"Purpose: To compare the monocular uncorrected visual acuity (UCVA) and contrast sensitivity (CS) of three enhanced monofocal intraocular lenses (IOLs) under emmetropic and mild myopic refractive targets.Study design: Single-center retrospective observational study.Methods: Among 198 patients (244 eyes) who underwent uneventful cataract surgery with enhanced monofocal IOL implantation (Tecnis Eyhance [DIB00V, E group], Vivinex Impress [XY1-EM, I group], NIDEK NSP-3 [N group]) with emmetropia or mild myopia (-1.00D), refractive targets, monocular UCVA at six different distances (5, 1, 70, 50, 40, and 30 cm) and CS with and without glare were assessed 1 month postoperatively and compared using the Kruskal-Wallis test followed by the Steel-Dwass post-hoc test.Results: In the emmetropic group, UCVA for all IOLs achieved ≤ 0.2 logMAR from 5 m to 50 cm, with significantly better UCVA at 5 m in the E than I group (p = 0.0300) and at 50 cm in the I than N group (p = 0.0242). For mild myopia, the N group achieved better UCVA at 5 m (p = 0.0066), the I group showed superior near-visual acuity at 30 cm than the E group (p = 0.0457), and UCVA for all IOLs achieved ≤ 0.2 logMAR from 1 m to 40 cm, with the highest CS at 6, 12, and 18 cycles per degree, with and without glare, in the E group. These findings suggest that combining enhanced monofocal IOLs with mild myopic targeting (-1.0 D) may optimize functional vision for everyday activities, particularly in older adults who rely on safe intermediate and near vision in daily life.Conclusions: All IOLs showed good UCVA. The E, I, and N groups demonstrated balanced visual performance, with superior contrast sensitivity, superior near-to-intermediate vision, and superior distance vision, respectively.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"813-819"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Paired‑eye comparison of photocoagulation versus intravitreal bevacizumab for retinopathy of prematurity: long‑term visual, refractive, and ocular biometric outcomes at corrected ages 1, 5, and 9 years. 矫正：光凝与玻璃体内贝伐单抗治疗早产儿视网膜病变的配对眼比较：矫正后1岁、5岁和9岁的长期视力、屈光和眼部生物特征结果。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 DOI: 10.1007/s10384-026-01405-5

Yoshimi Fukushima, Machi Takata, Akiteru Kawahara, Hideki Chuman, Nobuhisa Naoi, Yasuhiro Ikeda

引用次数: 0

Challenge to the concept of surgical dose-response for moderate to large angle exotropia. 对中、大角度外斜视手术剂量反应概念的挑战。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-04-25 DOI: 10.1007/s10384-026-01344-1

Soh Youn Suh, Qingyu Meng, Ami Tamhaney, Joseph L Demer

{"title":"Challenge to the concept of surgical dose-response for moderate to large angle exotropia.","authors":"Soh Youn Suh, Qingyu Meng, Ami Tamhaney, Joseph L Demer","doi":"10.1007/s10384-026-01344-1","DOIUrl":"10.1007/s10384-026-01344-1","url":null,"abstract":"Purpose: To determine whether the effect of three muscle surgery for moderate to large angle exotropia can be better predicted by surgical dosage, or by pre-operative exotropia angle. We examined cases where identical surgical dose was performed for a wide range of preoperative angles 30 to 55Δ.Study design: Retrospective, interventional case study.Methods: Patients with exotropia 30-55Δ who underwent bilateral lateral rectus (BLR) muscle recession 7 mm and 4 mm unilateral medial rectus (UMR) muscle plication between 2014 and 2024 were included. Surgical effect was analyzed by linear regression against the amount of preoperative exotropia, as well as total millimeters of recession and plication. Success was defined as less than 10Δ exotropia or 5Δ esotropia.Results: Thirty-four patients were included with 32 ± 27 (standard deviation, SD) years mean age. Mean preoperative exotropia at distance was 42 ± 6Δ (range 30-55Δ), and 40 ± 16Δ (range 6-70Δ) at near. Surgical effect varied from 29Δ to 75Δ, averaging 42 ± 10Δ, giving a mean dose response of 2 ± 1Δ/mm. Linear regression showed that average surgical effect was equal to pre-operative deviation, accounting for 34-36% of variation in surgical effect. Success rate of this operation for all exotropia angles was 76% at 2 months mean followup.Conclusions: Surgical effect for moderate to large angle exotropia does not strongly depend on surgical dose, so that successful outcomes measured 2 months post-operatively are obtained by performing a numerically identical procedure regardless of the pre-operative angle exceeding 30Δ. Since outcome is attributable more to the biological response than to amount of surgery, pre-operative measurements require only sufficient precision to confirm that the angle is moderate to large.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"759-764"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjunctival allergic inflammation involving the interleukin-23/T helper type 17 immune axis in an experimental allergic conjunctivitis mouse model. 实验性变应性结膜炎小鼠模型中涉及白细胞介素-23/T辅助型17免疫轴的结膜过敏性炎症

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-02-13 DOI: 10.1007/s10384-026-01333-4

Rumi Adachi, Jun Shoji, Noriko Inada, Akiko Tomioka, Satoru Yamagami

{"title":"Conjunctival allergic inflammation involving the interleukin-23/T helper type 17 immune axis in an experimental allergic conjunctivitis mouse model.","authors":"Rumi Adachi, Jun Shoji, Noriko Inada, Akiko Tomioka, Satoru Yamagami","doi":"10.1007/s10384-026-01333-4","DOIUrl":"10.1007/s10384-026-01333-4","url":null,"abstract":"Purpose: To investigate the role of the interleukin-23 (IL-23)/T helper type 17 (Th17) immune axis in conjunctival allergic inflammation using a murine model of experimental allergic conjunctivitis (EAC).Study design: Experimental study.Methods: BALB/c mice were assigned to four groups: control (untreated), allergy (EAC), IL-23 (EAC with IL-23 eyelid injection), and non-sensitized IL-23 (non-sensitized with IL-23 eyelid injection). Conjunctival tissue was analyzed histologically to quantify eosinophil and neutrophil infiltration. Gene expression of mRNA in conjunctival tissue was assessed using a PCR array and quantitative RT-PCR.Results: Eosinophilic and neutrophilic infiltration in the subconjunctival tissue was more pronounced in the IL-23 group than in the allergy and control groups. PCR array and quantitative RT-PCR analyses revealed significantly elevated Ccl17/Tarc mRNA expression in the IL-23 group compared to the allergy group. IL-17A mRNA, undetectable in the allergy group, was expressed in the IL-23 group. Additionally, PCR array comparisons between the IL-23 and non-sensitized IL-23 groups showed a significant increase in Rorc and Il1r1 expression in the IL-23 group. At the same time, Mmp3, Ccl7, and Ccr2 were significantly upregulated in the non-sensitized IL-23 group. RT-PCR analysis also demonstrated higher IL-17A mRNA levels in the non-sensitized IL-23 group than in the IL-23 group.Conclusion: IL-23 induces mixed eosinophilic-neutrophilic inflammation in conjunctival tissue, characterized by enhanced Th2 and weak Th17 responses in a murine model of EAC. These findings suggest a modulatory role of the IL-23/Th17 axis in influencing the severity and phenotype of allergic conjunctival inflammation.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1027-1036"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0