Japanese Journal of Ophthalmology最新文献

{"title":"Efficacy and safety of ROH-101 (0.15% ganciclovir gel) for cytomegalovirus corneal endotheliitis: an open-label, uncontrolled, phase 3 study in Japan.","authors":"Noriko Koizumi, Dai Miyazaki, Seiichiro Sugita, Chie Sotozono, Tsutomu Inatomi, Hiroshi Goto, Atsushi Shiraishi, Shuichiro Eguchi, Shin-Ichiro Ito, Yuichi Hori, Eiichi Uchio, Takeshi Soma, Takeo Fukuchi, Ken Hayashi, Yusuke Takeuchi, Yoshitsugu Inoue","doi":"10.1007/s10384-025-01168-5","DOIUrl":"https://doi.org/10.1007/s10384-025-01168-5","url":null,"abstract":"<p><strong>Purpose: </strong>Cytomegalovirus (CMV) corneal endotheliitis often causes severe visual impairment owing to irreversible corneal endothelial dysfunction. Given the side effects of systemic antiviral therapy, development of an approved topical antiviral agent for CMV corneal endotheliitis is desirable. This study evaluated the efficacy and safety of topical 0.15% GCV gel, ROH-101, in the treatment of CMV corneal endotheliitis in Japanese patients.</p><p><strong>Study design: </strong>Open-label, multicenter, uncontrolled, phase 3 study (jRCT2051210064).</p><p><strong>Methods: </strong>The study was conducted from August 2021 to December 2022, with a 2-week run-in period with 0.1% fluorometholone eye drops alone, a 12-week treatment period with additional ROH-101, and a 24-week post-treatment observation period after discontinuation of ROH-101. The primary endpoint was the proportion of patients achieving a CMV DNA copy number in the aqueous humor of less than 10³ copies/mL at week 12. The clinical findings and safety were assessed over the treatment and post-treatment observation periods.</p><p><strong>Results: </strong>Twelve eyes of 12 patients with PCR-proven CMV corneal endotheliitis were enrolled. Treatment was discontinued in 1 eye owing to an adverse event. The other 11 eyes completed 12 weeks of treatment with 63.6% achieving the primary endpoint. The clinical findings, such as corneal edema, coin-shaped lesions, and anterior chamber inflammation, improved in all 11 eyes and did not worsen in 8 eyes that completed the post-treatment observation period. Endothelial cell density was well maintained, and none of the 11 eyes showed corneal endothelial dysfunction. Mild adverse drug reactions were reported in 3 eyes (8.3%).</p><p><strong>Conclusion: </strong>ROH-101 was a safe and efficacious treatment in Japanese patients diagnosed with CMV corneal endotheliitis.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes and the association between early detection of retinal pigment epithelial atrophy and remission after loading dose in eyes with retinal angiomatous proliferation.","authors":"Wataru Kikushima, Yoichi Sakurada, Daphne Viel Tsuru, Kenji Kashiwagi","doi":"10.1007/s10384-025-01189-0","DOIUrl":"https://doi.org/10.1007/s10384-025-01189-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between early detection of retinal pigment epithelial (RPE) atrophy after anti-vascular endothelial growth factor (VEGF) treatment and the long-term treatment outcomes in eyes with retinal angiomatous proliferation (RAP).</p><p><strong>Study design: </strong>A retrospective observational study METHODS: All patients with treatment-naive RAP initially received three monthly anti-VEGF administration with or without photodynamic therapy (PDT), followed by as-needed anti-VEGF administration. At 12 months post-injection, they were divided into two groups depending on the presence or absence of RPE atrophy. The visual and anatomic outcomes, and the incidence of 12-month remission were investigated within a 48-month follow-up.</p><p><strong>Results: </strong>Thirty-seven eyes of 37 patients were included. The mean age was 80.4 ± 7.0 years, 54% were women. In the atrophy (+) group, 58.3% of patients achieved 12-month remission, significantly higher than the atrophy (-) group (p = 0.04). During the study period, best corrected visual acuity in the atrophy (+) group deteriorated from 0.50 ± 0.43 logMAR to 0.66 ± 0.47 logMAR (p = 0.14), while in the atrophy (-) group, it deteriorated significantly from 0.48 ± 0.27 logMAR to 0.76 ± 0.42 logMAR (p = 6.7×10^-3). The mean additional injections in the atrophy (+) group were significantly smaller compared with the atrophy (-) group at 3.5 ± 4.7 versus 15.3 ± 4.3, respectively (p = 9.0×10^-6).</p><p><strong>Conclusion: </strong>Early detection of RPE atrophy was associated with the incidence of 12-month remission and reduced number of additional injections. The formation of RPE atrophy might suggest a decrease in the disease activity of RAP.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of retinal ganglion cell complex thinning by visual field patterns following post-geniculate lesions.","authors":"Toshio Kurokawa, Rumi Kobayashi, Naoko Ueda, Takekazu Ohi","doi":"10.1007/s10384-025-01174-7","DOIUrl":"https://doi.org/10.1007/s10384-025-01174-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between retinal ganglion cell complex (GCC) thinning following post-geniculate lesions and the time elapsed since cerebrovascular disorder (CVD) onset.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>Forty-seven patients with hemianopic visual field defects (VFD) due to post-geniculate lesions were retrospectively enrolled from our clinical optical coherence tomography (OCT) database. GCC thickness was measured using spectral-domain OCT, with a 6 mm circle centered on the fovea divided into hemianopic and unaffected sides. The decline rate (DR) was calculated as the percentage reduction in GCC thickness on the hemianopic side relative to the unaffected side.</p><p><strong>Results: </strong>Patients were grouped based on VFD patterns: complete homonymous hemianopia (A), homonymous hemianopia with macular sparing (B), homonymous scotomatous defects (C), superior quadrantanopia (D), and inferior quadrantanopia (E). A positive correlation (r = 0.581, p < 0.001) was found between the time elapsed since CVD onset and DR. More than 5% DR was observed in 29 of 47 cases (61.7%). Significant differences were noted between group A (specifically, the temporal lobe lesion) and group B (p = 0.0183), as well as between group A and group C (p = 0.0378).</p><p><strong>Conclusion: </strong>A significant correlation was observed between DR and the time elapsed. Several factors, such as lesion location, type, size, and the involvement of gray or white matter, influence retrograde trans-synaptic degeneration (RTSD). Our findings suggest that RTSD is influenced by the distance from the lateral geniculate nucleus (LGN).</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors of late-onset intraocular pressure elevation after vitrectomy with silicone oil tamponade.","authors":"Dong Woo Kim, Se Joon Woo, Kwangsic Joo, Min Seok Kim","doi":"10.1007/s10384-025-01184-5","DOIUrl":"https://doi.org/10.1007/s10384-025-01184-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the incidence and risk factors of late-onset intraocular pressure (IOP) elevation in patients who underwent pars plana vitrectomy with silicone oil (SO) injection for the management of various vitreoretinal pathologies.</p><p><strong>Study design: </strong>A retrospective observational study.</p><p><strong>Methods: </strong>A single-center study involving 135 eyes of 129 patients who underwent vitrectomy with SO injections between January 2018 and May 2023 and maintained SO tamponade for ≥1 month. Eyes with prior glaucoma surgery; a history of SO injection; SO removal or exchange within a month; a follow-up period of <1 month; or those who showed IOP elevation on postoperative day 1 were excluded from the analysis. Late-onset IOP elevation was defined as IOP ≥ 21 mm Hg after postoperative day 7.</p><p><strong>Results: </strong>Late-onset IOP elevation developed in 22.2% (30/135 eyes) and the mean onset was 38.0±53.4 days (7-251 days) after surgery. In the multivariate logistic regression analysis, late-onset IOP elevation was associated with pre-existing glaucoma (odds ratio [OR], 7.16; P=0.041), longer axial length (OR, 1.40, P=0.037), and higher preoperative IOP (OR, 1.12; P=0.037). Among the patients with late-onset IOP elevation, 50% (15/30) required oral acetazolamide despite the administration of IOP-lowering eye drops. Among them, surgical intervention was required in 8 cases (53.3%).</p><p><strong>Conclusion: </strong>Late-onset IOP elevation is a common complication associated with SO tamponade. Risk factors for late-onset IOP elevation are pre-existing glaucoma, longer axial length, and preoperative higher IOP. Since a substantial proportion of eyes require surgical intervention, proactive measures should be considered for effective IOP control.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remarkable visual improvement in Leber hereditary optic neuropathy.","authors":"Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1007/s10384-025-01185-4","DOIUrl":"https://doi.org/10.1007/s10384-025-01185-4","url":null,"abstract":"<p><strong>Purpose: </strong>Leber hereditary optic neuropathy (LHON) typically has a poor visual outcome. In this study, we examined 8 cases of LHON that demonstrated remarkable visual improvement.</p><p><strong>Study design: </strong>Retrospective observational study, clinical case series METHODS: We analyzed the clinical histories and outcomes of 8 patients (16 eyes) whose best corrected visual acuity (BCVA) improved to 0.7 or higher in at least 1 eye.</p><p><strong>Results: </strong>The median age of onset of the 7 male patients and 1 female patient was 17 years (range 8-58). Genetic testing revealed m.11778G>A mutations in 6 and m.14484T>C mutations in 2 of the patients. Of the 16 eyes, 15 improved to a BCVA of 0.7 or higher, whilst 1 eye achieved a final BCVA of 0.5. The lowest BCVA was below 0.1 in 12/16 eyes. BCVA improved to 0.1 or better within 1 year in 6/12 eyes and to 0.7 or better within 2 years in 12/15 eyes. In 10 eyes monitored by use of Humphrey Field Analysis (HFA; Fastpac, 30-2 program), the mean deviation improved from - 13.2 dB (- 23.6 to - 4.54) at its lowest to - 5.0 dB (- 15.6 to - 0.9) at the final measurement. Final HFA showed residual defects in the temporal region in 7/16 eyes. In the chronic phase, 10/12 eyes displayed either normal optic disc findings or partial temporal pallor.</p><p><strong>Conclusion: </strong>In LHON cases with remarkable visual improvement, the recovery began earlier, and the visual field defects were relatively mild and tended to persist in the temporal region after improvement. Understanding these cases of notable improvement may inform future treatment strategies.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year treatment outcomes after anti-vascular endothelial growth factor therapy in age-related macular degeneration with type 2 macular neovascularization in Japanese patients.","authors":"Yosuke Fukuda, Satomi Shiose, Shoji Notomi, Yusuke Maehara, Kenichiro Mori, Sawako Hashimoto, Kumiko Kano, Keijiro Ishikawa, Koh-Hei Sonoda","doi":"10.1007/s10384-025-01178-3","DOIUrl":"https://doi.org/10.1007/s10384-025-01178-3","url":null,"abstract":"<p><strong>Purpose: </strong>Neovascular age-related macular degeneration (nAMD) with type 2 macular neovascularization (MNV) has a relatively good responsiveness to anti-vascular endothelial growth factor (anti-VEGF) therapy compared to type 1 MNV. This study aimed to analyze the treatment outcomes of nAMD patients with type 2 MNV and identify factors associated with fluid recurrence.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>This study included treatment-naïve nAMD patients with type 2 MNV but without type 1 MNV, who received 3-monthly anti-VEGF injections as the loading phase and were followed up for over 2 years. The treatment outcomes were compared between proactive (PA) and reactive regimen (RA) groups. In addition, we investigated the factors associated with fluid recurrence in the RA group.</p><p><strong>Results: </strong>This retrospective study included 65 eyes from 65 patients. Best-corrected visual acuity (BCVA) and central macular thickness significantly improved in both the PA and RA groups. Although there was no significant difference between the two groups, the RA group showed a trend towards better BCVA. The presence of fluid three or four months after the initial injection was associated with fluid recurrence in the RA group (p = 0.02).</p><p><strong>Conclusion: </strong>For nAMD patients with type 2 MNV, a proactive regimen is generally preferred. However, for nAMD patients with type 2 MNV achieving fluid resolution after the loading phase, it may be possible to maintain BCVA and reduce the number of anti-VEGF injections by following a reactive regimen.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of intraoperative optical coherence tomography in filtration surgery using MicroShunt.","authors":"Saori Igarashi, Mitsuhiro Matsuzaki, Marika Hirota, Wakako Miyazaki, Shogo Yamamoto, Satoru Yoshimizu, Hirofumi Uyama, Satoshi Yokota, Masashi Fujihara, Fumitaka Hirose, Yasuo Kurimoto","doi":"10.1007/s10384-025-01183-6","DOIUrl":"https://doi.org/10.1007/s10384-025-01183-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the utility of intraoperative optical coherence tomography (OCT) in filtration surgery using PRESERFLO^® MicroShunt.</p><p><strong>Study design: </strong>Single-center prospective observational study METHODS: Filtration surgery using the MicroShunt was performed on 14 patients (15 eyes) diagnosed with open-angle glaucoma at our institution. The insertion pathway was created using a knife under intraoperative OCT guidance, and the position of the MicroShunt was verified after insertion. In cases of inadequate positioning, a new insertion pathway was created. Furthermore, the correct position was confirmed postoperatively using anterior segment OCT.</p><p><strong>Results: </strong>In all cases, the real-time observation or replay playback of intraoperative OCT allowed for the visualization of the positional relationship between the device and surrounding tissues. This provided valuable assistance in determining the adequacy of the insertion pathway. In certain cases, the knife or inserted MicroShunt was in contact with the cornea or iris, leading to a revision of the insertion pathway. Regardless of the case, at the end of each surgery confirmation was made that the inserted MicroShunt was fixed in the proper position in the anterior chamber. Postoperative anterior segment OCT also revealed its presence in a similar position.</p><p><strong>Conclusion: </strong>Intraoperative OCT is a valuable tool for ensuring a more secure insertion in filtration surgery using MicroShunt.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of dry eye associated with autoimmune diseases.","authors":"Ayano Yoshimura, Yuka Hosotani, Nahomi Masuda, Fumi Gomi","doi":"10.1007/s10384-025-01172-9","DOIUrl":"https://doi.org/10.1007/s10384-025-01172-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the characteristics of dry eye in patients with autoimmune disease.</p><p><strong>Study design: </strong>Retrospective clinical study.</p><p><strong>Methods: </strong>Two hundred and fifty-two eyes from 252 patients (12 men and 240 women, mean age 59.8 ±15.2) with autoimmune disease and dry eye were enrolled. Patients were divided into three groups: primary Sjogren's syndrome, secondary Sjogren's syndrome, and autoimmune disease without Sjogren's syndrome.</p><p><strong>Results: </strong>Among all cases, the mean fluorescein breakup time (FBUT) was 2.7 ± 1.6 s, the van Bijesterveld corneal score was 0.8 ± 0.8, the conjunctival score was 1.5 ± 1.7; and the Schirmer 1 test value was 8.4 ± 8.2 mm. Among all cases, the fluorescein breakup pattern (FBUPs) was tear-deficiency-type dry eye in 43% of eyes (area 11%, line 32%), and short FBUT-type dry eye in 57% (dimple 31%, spot 10%, random 16%). Conjunctival scores showed significant positive correlations with anti-SS-A and anti-SS-B antibody titers in the primary and secondary Sjogren's syndrome groups.</p><p><strong>Conclusion: </strong>More than half of the dry eyes associated with autoimmune diseases were short FBUT-type. Patients with autoimmune disease should be aware of dry eye, even without a diagnosis of Sjogren's syndrome.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prolonged digital device use on acquired comitant esotropia: ACE-DD study 2.","authors":"Hirohito Iimori, Noriko Nishikawa, Sachiko Nishina, Tomoyo Yoshida, Takafumi Mori, Osamu Hieda, Akiko Hikoya, Miwa Komori, Shion Hayashi, Takashi Negishi, Toshiaki Goseki, Yoshiko Sugiyama, Akiko Kimura, Takeshi Morimoto, Yukiko Shimizu, Tamami Shimizu, Yoshimi Yokoyama, Hiroko Suzuki, Sadao Suzuki, Noriyuki Azuma, Miho Sato","doi":"10.1007/s10384-025-01171-w","DOIUrl":"https://doi.org/10.1007/s10384-025-01171-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate changes in strabismus angles in children and young adult patients with recent onset of constant acquired comitant esotropia (ACE) following instructions on hand-held digital devices (DD).</p><p><strong>Study design: </strong>Prospective multicenter non-randomized interventional study.</p><p><strong>Methods: </strong>This study included subjects aged 5-35 years who developed ACE within 1 year. Subjects were divided into two groups: (i) subjects who used DD for an average of ≥120 minutes/day for junior high-school students and older and ≥60 minutes/day for primary-school students and younger (DD+); and (ii) subjects who used DD for less than that (DD-) based on the questionnaire at the study's start. During the initial visit, glasses were prescribed when necessary; verbal instructions on DD use including time reduction and viewing-distance elongation were provided. For each group, strabismus angles at the initial visit and at 3 months were compared. Cure was defined as esophoria within 8 prism diopters without symptoms.</p><p><strong>Results: </strong>In total, 181 cases were investigated. At baseline, strabismus angles in DD+ and DD- groups were 23±14 PD and 25±15 PD at near and 25±13 PD and 27±14 PD at distance, respectively. At 3 months, they were 22±16 PD and 25±15 PD at near and 23±14 PD and 27±13 PD at distance, respectively. Only in the DD+ group, reduction in strabismus angle was observed, but this was not clinically significant. Ten and 1 subjects in DD+ and DD- groups were cured.</p><p><strong>Conclusion: </strong>Although changes in strabismus angles were not large enough, DD use instructions were beneficial for some ACE subjects.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular complication induced by anticancer drug S-1: association with drug concentrations in tears.","authors":"Masakazu Yamada, Tomoyuki Kamao, Atsushi Shiraishi, Jo Sakai, Yuichi Ohashi","doi":"10.1007/s10384-025-01180-9","DOIUrl":"https://doi.org/10.1007/s10384-025-01180-9","url":null,"abstract":"<p><strong>Purpose: </strong>S-1 is an orally active anticancer drug known to cause ocular adverse events (AEs), including lacrimal passage obstruction and corneal complications. This study investigated tear concentrations of 5-fluorouracil (5-FU) and tegafur (FT) in patients receiving S-1 treatment and their relationship with ocular AEs.</p><p><strong>Study design: </strong>Multicenter prospective cohort study.</p><p><strong>Methods: </strong>We recruited patients scheduled for S-1 chemotherapy. After initial ophthalmologic examinations at enrollment, serial examinations were performed during the courses of S-1 administration for up to 1 year. Tear samples were collected using Schirmer test strips at the end of the first course of S-1 treatment. 5-FU and FT concentrations were measured using high-performance liquid chromatography.</p><p><strong>Results: </strong>The study cohort comprised 94 patients among whom 38 (40.4%) developed ocular AEs, including 32 (34.0%) corneal AEs, 13 (13.8%) lacrimal AEs, and 7 (7.4%) patients who developed both. The tear FT concentrations in the ocular AE group were significantly higher compared with the group without ocular AEs (3.15 ± 3.09 vs. 1.86 ± 1.56 µg/mL; p = 0.017). There was no difference in tear 5-FU concentration between the 2 groups. The FT concentration in tears in the corneal and lacrimal AE groups was significantly higher than in the group without ocular AEs (p = 0.013 and 0.030, respectively).</p><p><strong>Conclusion: </strong>FT concentration in tears due to oral S-1 therapy is associated with corneal or lacrimal AEs. Measuring FT concentration in tears or plasma may be useful for predicting the onset of ocular AEs.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}