Japanese Journal of Ophthalmology最新文献

Outcomes of a randomised trial comparing 360° and 180° schlemm's canal incisions in suture trabeculotomy ab interno for primary open-angle glaucoma and exfoliation glaucoma: a 5-year analysis. 一项比较缝合小梁切开术治疗原发性开角型青光眼和剥脱型青光眼的360°和180°schlemm管切口的随机试验的结果：5年分析。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-24 DOI: 10.1007/s10384-025-01236-w

Tomoki Sato, Takahiro Kawaji

{"title":"Outcomes of a randomised trial comparing 360° and 180° schlemm's canal incisions in suture trabeculotomy ab interno for primary open-angle glaucoma and exfoliation glaucoma: a 5-year analysis.","authors":"Tomoki Sato, Takahiro Kawaji","doi":"10.1007/s10384-025-01236-w","DOIUrl":"https://doi.org/10.1007/s10384-025-01236-w","url":null,"abstract":"Purpose: We aimed to report the 5-year efficacy and safety data of suture trabeculotomy ab interno (SLOT ab interno) in patients with primary open-angle glaucoma and exfoliation glaucoma.Study design: Single-centre, three-arm randomised trial.Methods: Ninety-nine eyes of 99 patients were randomly assigned to one of three groups: the 360° (n = 34), upper-180° (n = 34), and lower-180° (n = 31) groups. We evaluated intraocular pressure (IOP), medication use, and visual field progression. Surgical success (with or without medication) was defined as IOP ≤21 mmHg with a ≥20% reduction (criterion A) or IOP ≤15 mmHg with a ≥ 20% reduction (criterion B). Visual field progression was assessed by MD values at fixed postoperative time points and by the MD slope (dB/year).Results: Fifty-six of 99 eyes (56.5%) completed 5 years of follow-up. At 5 years, the mean IOP decreased from 18.8 ± 5.7 to 13.5 ± 3.1 mmHg (28% reduction, p<0.001), with medication use decreasing from 3.3 ± 1.1 to 2.0 ± 1.7 (p=0.005) and a mean MD slope of -0.2 dB/year. No significant differences in surgical success rates (criteria A and B), MD values, or MD slopes were observed among the groups.Conclusion: The extent of Schlemm's canal incisions (360°, upper-180°, or lower-180°) during SLOT ab interno has no significant effect on IOP reduction or medication use over 5 years.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconsideration of conversion to multiple sclerosis: one-year cerebral lesion appearance rate of Japanese aquaporin-4 antibody-negative optic neuritis patients. 日本水通道蛋白-4抗体阴性视神经炎患者一年内脑损伤出现率的研究

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-21 DOI: 10.1007/s10384-025-01235-x

Satoshi Ueki, Yukari Hasegawa, Tetsuhisa Hatase, Izumi Kawachi, Takeo Fukuchi

{"title":"Reconsideration of conversion to multiple sclerosis: one-year cerebral lesion appearance rate of Japanese aquaporin-4 antibody-negative optic neuritis patients.","authors":"Satoshi Ueki, Yukari Hasegawa, Tetsuhisa Hatase, Izumi Kawachi, Takeo Fukuchi","doi":"10.1007/s10384-025-01235-x","DOIUrl":"10.1007/s10384-025-01235-x","url":null,"abstract":"Purpose: To analyze the rate of new cerebral lesions' appearance within 6-12 months in Japanese optic neuritis patients who at onset had no cerebral lesions suggestive of multiple sclerosis (MS) and were negative for aquaporin-4 (AQP4) antibodies.Study design: Retrospective study.Methods: Medical records of 66 adult patients with optic neuritis were reviewed. Patients positive for AQP4, myelin oligodendrocyte glycoprotein, or antinuclear antibodies were excluded. Those without cerebral lesions on initial magnetic resonance imaging (MRI) underwent follow-up MRI within 6-12 months. Clinical characteristics and subsequent neurological diagnoses were analyzed.Results: Forty-seven patients met the inclusion criteria (mean age, 41.9±16.7 years; 13 men, 34 women). Forty-two cases were unilateral, five bilateral; 19 had disc swelling, and 28 did not. The mean worst logMAR was 1.13±0.96. Two patients experienced recurrence within 1 year. Of the 27 patients without initial cerebral lesions, 20 underwent follow-up MRI; 3 (15%) developed new lesions. These three were later diagnosed as two MS and one suspected MS cases.Conclusion: Follow-up MRI within 6-12 months revealed new cerebral lesions in 15% of patients, with 10% diagnosed with MS. This highlights the importance of follow-up imaging even in AQP4 antibody-negative optic neuritis patients without initial cerebral lesions, especially in the absence of other diseases like neuromyelitis optica spectrum disorders.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scleral thickness in patients with obstructive sleep apnea syndrome. 阻塞性睡眠呼吸暂停综合征患者巩膜厚度的变化。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-21 DOI: 10.1007/s10384-025-01234-y

Zeynep Akgun, Cumali Degirmenci, Sezai Tasbakan, Ozen K Basoglu, Melis Palamar

{"title":"Scleral thickness in patients with obstructive sleep apnea syndrome.","authors":"Zeynep Akgun, Cumali Degirmenci, Sezai Tasbakan, Ozen K Basoglu, Melis Palamar","doi":"10.1007/s10384-025-01234-y","DOIUrl":"10.1007/s10384-025-01234-y","url":null,"abstract":"Purpose: Evaluation of scleral thickness with anterior segment optical coherence tomography (AS-OCT) in patients with obstructive sleep apnea syndrome (OSAS).Study design: Cross-sectional study.Methods: A total of 30 severe (Group 1), 30 moderate (Group 2) and 30 mild (Group 3) OSAS patients and 22 healthy volunteers (Group 4) were included in the study. Scleral thickness measurements were taken with AS-OCT, 6 mm, 4 mm and 2 mm posterior to the scleral spur, in four gaze positions. Data and findings were examined comparatively.Results: At 6 mm posterior to the scleral spur, the mean thickness was found to be significantly higher in all quadrants in Group 1 (p<0.05 for all). Superior thickness was higher in Group 2 compared to Group 4 (p=0.034). At 4 mm posterior to the scleral spur; in Group 1, the mean thickness was found higher than Group 2 and 3 only in the inferior (p=0.01, p=0.021, respectively) and was found higher than Group 4 in the nasal and inferior (p<0.001, p=0.006, respectively). At 2 mm posterior to the scleral spur; significant difference was observed between Groups 1 and 2 only in the inferior (p=0.002), between Groups 1 and 3 in the nasal and inferior (p=0.029, p=0.002), and between Groups 1 and 4 the in nasal and inferior (p=0.002, p<0.001).Conclusion: The scleral thickness measured from 6 mm posterior to the scleral spur was higher in all quadrants in patients with severe OSAS. It is possible that the increase in scleral thickness, especially in severe OSAS, is due to extracellular matrix accumulation in the scleral tissue.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A single center experience of intraocular pressure control with glaucoma drainage device use in pediatric and adult patients. 青光眼引流装置在儿童和成人患者中控制眼压的单中心经验。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-21 DOI: 10.1007/s10384-025-01214-2

Armin Garmany, Sepideh Jamali Dogahe, Kit Knier, Felix Kung, Jason Sargent, David Hodge, Cheryl Khanna

{"title":"A single center experience of intraocular pressure control with glaucoma drainage device use in pediatric and adult patients.","authors":"Armin Garmany, Sepideh Jamali Dogahe, Kit Knier, Felix Kung, Jason Sargent, David Hodge, Cheryl Khanna","doi":"10.1007/s10384-025-01214-2","DOIUrl":"10.1007/s10384-025-01214-2","url":null,"abstract":"Purpose: This retrospective cohort compared the cumulative probability of success for glaucoma drainage device (GDD) implantation in pediatric and adult patients.Study design: This retrospective study enrolled adult and pediatric patients who had received a GDD between January 1, 1985 and December 31, 2017.Methods: Kaplan-Meier method was used to estimate the cumulative probability of success in the pediatric and adult patients. Successful intraocular pressure (IOP) control was defined as (i) a 20% reduction from baseline and (ii) IOP>6 and <18. Inadequate IOP control and failure were defined as a violation of these two criteria over two consecutive visits. Cox proportional hazards models enabled assessing the influence of sex, GDD location, and GDD type on IOP control.Results: A total of 425 adult eyes from 372 individuals and 41 pediatric eyes from 28 individuals were included. The median follow-up time was 55 months for adults and 87 months for children. Superior temporal GDD placement was most employed for both (p=0.16). Adults were more likely to receive a Baerveldt 350 (p=0.04) and children were more likely to receive an Ahmed S2 (p<0.001). Adults and children had a median survival time of 2.99 and 0.82, respectively, and did not have a statistically significant difference in GDD failure rate (p=0.18). Additionally, sex, GDD location, and GDD type did not affect the success rate.Conclusions: Children and adults had a similar cumulative probability of success following GDD implantation. This study found that GDD type, GDD location, and glaucoma type did not influence the probability of successful IOP control.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a reliability criterion for the binocular Esterman visual field test. 双目Esterman视野测试可靠性准则的建立。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-21 DOI: 10.1007/s10384-025-01238-8

Kazunori Hirasawa, Akari Nagayama-Ito, Chiho Maruta-Akaishizawa, Nobuyuki Shoji

{"title":"Development of a reliability criterion for the binocular Esterman visual field test.","authors":"Kazunori Hirasawa, Akari Nagayama-Ito, Chiho Maruta-Akaishizawa, Nobuyuki Shoji","doi":"10.1007/s10384-025-01238-8","DOIUrl":"10.1007/s10384-025-01238-8","url":null,"abstract":"Purpose: To evaluate the repeatability of the binocular Esterman visual field (bEVF) test and develop a corresponding reliability criterion based on repeatability-associated factors.Study design: Prospective cross-sectional study.Methods: Ninety-five glaucoma patients underwent two bEVF tests on the same day using a Humphrey field analyzer. The repeatability of the bEVF was assessed by the agreement rate for seen and unseen points over all test points between the first and second tests. Factors associated with the repeatability were analyzed with multivariate linear regression analysis. Receiver operating characteristic (ROC) curve analysis was performed for those associated factors to identify the reliability criterion.Results: The mean agreement rate was 88.9% (95% confidence interval [CI]: 73.9%, 99.2%). A total of 44 patients (46.3%), 75 patients (78.9%), and 88 patients (92.6%) had agreement rates of more than 90%, 85%, and 80%, respectively. The false positive (FP) response rate of the bEVF test was negatively associated with the agreement rate (p<0.01). The best cutoff value according to the maximum Youden index for the FP response rate of the bEVF test was >7.1% (sensitivity = 71.0% and specificity = 88.0%), while the cutoff value based on a fixed 95% specificity was >12.1% (sensitivity = 28.6%).Conclusion: An approximately 90% agreement rate existed for the bEVF test when applied to glaucoma patients. The FP response rate was associated with the repeatability of the bEVF test, and 8% or at least 13% may serve as a useful reference to ensure an agreement rate of 80% or higher.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased macular atrophy area with photodynamic therapy over intravitreal aflibercept at 2-year follow-up of pachychoroid neovasculopathy. 在厚脉络膜血管病的2年随访中，光动力治疗增加了黄斑萎缩面积。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-21 DOI: 10.1007/s10384-025-01232-0

Hirokazu Kojima, Chieko Shiragami, Ayana Yamashita, Yukiko Miyoshi, Rie Osaka, Aoi Ono, Kiyoshi Suzuma

{"title":"Increased macular atrophy area with photodynamic therapy over intravitreal aflibercept at 2-year follow-up of pachychoroid neovasculopathy.","authors":"Hirokazu Kojima, Chieko Shiragami, Ayana Yamashita, Yukiko Miyoshi, Rie Osaka, Aoi Ono, Kiyoshi Suzuma","doi":"10.1007/s10384-025-01232-0","DOIUrl":"10.1007/s10384-025-01232-0","url":null,"abstract":"Purpose: To compare the therapeutic outcomes of intravitreal aflibercept injection (IVA) and reduced-fluence photodynamic therapy (rfPDT) for pachychoroid neovasculopathy (PNV) over 2 years.Study design: Observational, retrospective case series. Single-center study.Methods: This study involved 36 eyes of 36 patients with PNV. The IVA group comprised 18 eyes treated with IVA monotherapy (injection every 3 months followed by a pro re nata regimen), whereas the rfPDT group consisted of 18 eyes treated with rfPDT monotherapy. Post-treatment changes in best-corrected visual acuity (BCVA), macular atrophy (MA) area, central retinal thickness (CRT) and subfoveal choroidal thickness (SFCT) were compared between the 2 groups.Results: The IVA group received 8.94 ± 4.77 injections, whereas the rfPDT group received rfPDT 1.06 ± 0.24 times. The logMAR BCVA improved in both groups but did not differ between the 2 groups. The MA area increased from 0.163 ± 0.418 mm2 to 0.227 ± 0.480 mm2 (P = .024) and from 0.139 ± 0.402 mm2 to 0.597 ± 0.939 mm2 (P < .001) in the IVA and rfPDT groups, respectively, with the rfPDT group showing a greater increase than the IVA group (P = .013). The CRT was reduced in both groups but did not differ between the 2 groups. The SFCT was reduced in both groups, but the reduction was higher in the rfPDT group than in the IVA group (P = .027). The factors affecting change in the MA area were the treatment method and patient age.Conclusions: The increase in the MA area and the decrease in the SFCT were greater in the rfPDT group than in the IVA group for PNV, suggesting that IVA may be preferred over rfPDT for PNV treatment.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal changes after vitrectomy performed for macular hole retinal detachment. 黄斑裂孔视网膜脱离玻璃体切除术后脉络膜的改变。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-18 DOI: 10.1007/s10384-025-01218-y

Hirotaka Sumida, Ikuko Umeda, Takayuki Baba

{"title":"Choroidal changes after vitrectomy performed for macular hole retinal detachment.","authors":"Hirotaka Sumida, Ikuko Umeda, Takayuki Baba","doi":"10.1007/s10384-025-01218-y","DOIUrl":"https://doi.org/10.1007/s10384-025-01218-y","url":null,"abstract":"Purpose: To investigate changes in the choroidal area (CA), luminal area (LA), stromal area (SA), choroidal vascularity index (CVI), and choroidal thickness (CT) before and after vitrectomy in eyes with macular hole retinal detachment (MHRD).Study design: Retrospective observational study.Methods: We measured the best-corrected visual acuity (BCVA), intraocular pressure (IOP), CA, LA, SA, CVI, and CT preoperatively and 1, 3, and 6 months postoperatively in 10 eyes with MHRD. CA was measured within a 3-mm-wide area around the fovea in the horizontal and vertical images. LA and SA were quantified using the Niblack method, and CVI was calculated as the ratio of LA to CA. CT was measured at the subfovea and at 1 and 3 mm vertically and horizontally away from the fovea.Results: BCVA improved significantly at 1 and 3 months postoperatively (P = 0.036 and 0.016). IOP remained stable. CA and LA decreased significantly 6 months postoperatively in both the horizontal (P = 0.002 and 0.014) and vertical sections (P = 0.006 and 0.002). SA remained stable. CVI reduced significantly at 1 month horizontally and at 3 months vertically (both P = 0.027). CT decreased significantly in the subfovea at 3 and 6 months postoperatively (P = 0.027 and 0.020, respectively). Significant reductions were also observed at 1 mm nasal, temporal, and superior regions (P = 0.014, 0.014, and 0.004) and at 2 mm temporal and superior regions 1 month postoperatively (P = 0.020 and 0.014).Conclusion: Choroidal thinning was observed after vitrectomy in eyes with MHRD, driven by a reduction in the luminal area.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between acceleration of axial elongation and ocular biometry in schoolchildren. 学童轴向伸长加速度与眼生物测量的关系。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-17 DOI: 10.1007/s10384-025-01227-x

Takehiro Yamashita, Hiroto Terasaki, Takuto Hamada, Ryo Asaoka, Naoya Yoshihara, Naoko Kakiuchi, Taiji Sakamoto

{"title":"Relationship between acceleration of axial elongation and ocular biometry in schoolchildren.","authors":"Takehiro Yamashita, Hiroto Terasaki, Takuto Hamada, Ryo Asaoka, Naoya Yoshihara, Naoko Kakiuchi, Taiji Sakamoto","doi":"10.1007/s10384-025-01227-x","DOIUrl":"https://doi.org/10.1007/s10384-025-01227-x","url":null,"abstract":"Purpose: The speed of axial elongation typically slows during the growth phase; however, in some eyes, it accelerates, leading to myopia progression during school age. This study examined the association between ocular biometrics and the acceleration of axial elongation (AAE) in children.Study design: Longitudinal, prospective, observational study METHODS: This cohort study included 67 right eyes of elementary school children, tracked over six years (from ages 8.5 to 14.5). Annual measurements were conducted for optical axial length, anterior chamber depth, and lens thickness. Yearly axial elongation was calculated for each time period, and AAE was estimated using regression analysis coefficients. Spearman's correlation was used to evaluate the association between AAE and ocular biometric parameters measured in the first year.Results: The average axial length in the initial year was 23.37 ± 0.89 mm. By the sixth year, the mean axial elongation reached 1.50 ± 0.49 mm, while the average AAE was recorded as -0.015 ± 0.048. AAE was significantly correlated with first-year axial length (r = - 0.40, p < 0.001), anterior chamber depth (r = 0.33, p = 0.007), and lens thickness (r = - 0.42, p < 0.001).Conclusion: Some eyes with hyperopic ocular biometry at 8.5 years of age exhibited accelerated axial elongation during school age. Future research on myopia should consider both acceleration and axial elongation.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction in choroidal thickness associated with the progression of pachychoroid spectrum diseases. 脉络膜厚度减少与厚脉络膜谱系疾病的进展有关。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-14 DOI: 10.1007/s10384-025-01230-2

Hidetaka Matsumoto, Junki Hoshino, Kosuke Nakamura, Yosuke Asatori, Shoji Kishi, Hideo Akiyama

{"title":"Reduction in choroidal thickness associated with the progression of pachychoroid spectrum diseases.","authors":"Hidetaka Matsumoto, Junki Hoshino, Kosuke Nakamura, Yosuke Asatori, Shoji Kishi, Hideo Akiyama","doi":"10.1007/s10384-025-01230-2","DOIUrl":"https://doi.org/10.1007/s10384-025-01230-2","url":null,"abstract":"Purpose: Pachychoroid spectrum diseases reportedly progress from central serous chorioretinopathy (CSC) to pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). We investigated and compared choroidal thicknesses in the macular and peripheral areas among eyes with CSC, PNV, and PCV, as well as in normal control eyes.Study design: Retrospective case-control study.Methods: We studied 117 consecutive eyes with treatment-naïve pachychoroid spectrum diseases, comprising 52 eyes with CSC, 27 with PNV, and 38 with PCV, along with 106 age-, gender-, and axial length-matched normal control eyes. Widefield choroidal thickness maps generated by widefield optical coherence tomography were quantitatively analyzed. Mean choroidal thickness values in the macular, superotemporal, inferotemporal, superonasal, and inferonasal areas were determined, and then compared among the three pachychoroid spectrum diseases, and also assessed in normal controls.Results: The mean choroidal thickness reduction with aging was greater in eyes with pachychoroid spectrum diseases than in normal controls across all measured areas. Patient age increased in the order of CSC, PNV, and PCV, whereas there was no significant difference between PNV and PCV (P<0.01, CSC vs. PNV, CSC vs. PCV). Mean choroidal thickness exhibited a progressive decrease from CSC to PNV and PCV across all areas, although there were no significant differences between PNV and PCV (P<0.01, CSC vs. PCV, CSC vs. PNV).Conclusions: Overall choroidal thickness appears to decrease during the progression of pachychoroid spectrum diseases. This decline might be attributable to reduced choroidal blood flow due to the choriocapillaris attenuation associated with aging and pachychoroid pathophysiology.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of switching from existing anti-vascular endothelial growth factor drugs to ranibizumab biosimilar in neovascular age-related macular degeneration. 从现有抗血管内皮生长因子药物切换到雷尼单抗生物类似药治疗新生血管性年龄相关性黄斑变性的疗效。

IF 2.1 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-06-12 DOI: 10.1007/s10384-025-01224-0

Hikaru Ota, Jun Takeuchi, Ryo Nonogaki, Kazuma Tamura, Hiroki Kaneko, Koji M Nishiguchi

{"title":"Efficacy of switching from existing anti-vascular endothelial growth factor drugs to ranibizumab biosimilar in neovascular age-related macular degeneration.","authors":"Hikaru Ota, Jun Takeuchi, Ryo Nonogaki, Kazuma Tamura, Hiroki Kaneko, Koji M Nishiguchi","doi":"10.1007/s10384-025-01224-0","DOIUrl":"https://doi.org/10.1007/s10384-025-01224-0","url":null,"abstract":"Purpose: This study evaluated the clinical outcomes and aqueous humor cytokine levels in eyes with neovascular age-related macular degeneration (nAMD) switched from intravitreal aflibercept to ranibizumab biosimilar (BS).Study design: Prospective observational study.Methods: Thirty-eight eyes of 38 patients with nAMD who received aflibercept under a treat-and-extend (TAE) regimen were prospectively switched to ranibizumab BS. Eight eyes with cataracts undergoing surgery served as controls for aqueous humor cytokine analysis. Best-corrected visual acuity (BCVA) and anatomical outcomes were assessed over one year. The aqueous humor levels of vascular endothelial growth factor (VEGF)-A, angiopoietin-2 (Ang-2), and placental growth factor (PlGF) were measured before and after switching in eyes with nAMD and at surgery in controls.Results: Disease activity remained controlled in 94.3% of patients with nAMD for over one year. No significant changes were observed in the BCVA (P=0.65) after one year. Ang-2 levels remained unchanged (P=0.66) and were not significantly different between eyes with nAMD and controls both before (P=0.64) and after switching (P=0.30). PlGF levels also remained stable (P=0.12) but were significantly higher in eyes with nAMD than in controls both before (P<0.01) and after switching (P=0.03). VEGF-A levels significantly increased after switching (P<0.01) but remained lower than in the controls both before (P<0.01) and after switching (P=0.02).Conclusion: Switching from aflibercept to ranibizumab BS effectively maintained disease stability and cytokine balance in eyes with nAMD. These findings support ranibizumab BS as a viable and cost-effective alternative for long-term treatment.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0