Japanese Journal of Ophthalmology最新文献

{"title":"Surgical outcomes of primary filtering surgery in secondary childhood glaucoma patients: a retrospective cohort study.","authors":"Pukkapol Suvannachart, Sunee Chansangpetch, Supawan Surukrattanaskul, Kitiya Ratanawongphaibul, Anita Manassakorn, Visanee Tantisevi, Prin Rojanapongpun","doi":"10.1007/s10384-025-01256-6","DOIUrl":"https://doi.org/10.1007/s10384-025-01256-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term outcomes of primary filtering surgery, including trabeculectomy and combined trabeculotrabeculectomy (CTT), in secondary childhood glaucoma (SCG) patients.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>SCG patients, who underwent primary filtering surgery at two tertiary hospitals between 2008 and 2018, were reviewed. Surgical success was defined as an intraocular pressure (IOP) between 5 to 21 mmHg. Failure was defined as IOP outside those criteria for two consecutive visits, the need for additional surgery, or loss of light perception. Surgical success was evaluated using the Kaplan-Meier method.</p><p><strong>Results: </strong>Sixty-four eyes (50 patients) were included. Glaucoma associated with non-acquired ocular anomalies (SCG-O) included 31 eyes from 23 patients. Median age and follow-up time were 63.6 and 18 months, respectively. Overall success probabilities were 57.8% at 1 year, 55.1% at 3 years, and 50.1% at 5 years. For trabeculectomy (55 eyes), the success probabilities were 59.5% at 1 and 3 years, and 52.0 % at 5 years. For CTT (9 eyes), the success probabilities were 44.4% at 1 year, decreasing to 33.3% at 3 and 5 years. There was no statistically significant difference between trabeculectomy and CTT. Hypotony was the most common early complication. Two eyes developed phthisis bulbi.</p><p><strong>Conclusions: </strong>Primary filtering surgery in SCG patients showed a significant drop in the success rate to about 60% within the first year, followed by a slight decline thereafter, with a long-term success rate around 50%.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tomographic and biomechanical refractive findings in ocular pediatric allergy.","authors":"Wimolwan Tangpagasit, Suntaree Thitiwichienlert, Danaya Hongsuraphan","doi":"10.1007/s10384-025-01252-w","DOIUrl":"https://doi.org/10.1007/s10384-025-01252-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate corneal tomographic and biomechanical refractive findings in ocular pediatric allergy to identify high-risk eyes for ectasia.</p><p><strong>Study design: </strong>A cross-sectional study METHODS: Fifty-seven patients (5-18 years), diagnosed with allergic conjunctival disease (ACD) between July 2022 and September 2023, underwent comprehensive ocular examinations and clinical assessments. The Ocular Allergy Severity Score (OCAS Score) was calculated to assess the severity of signs and symptoms. Tomographic-based and biomechanical parameters, including Corvis Biomechanical Index (CBI), Tomographic and Biomechanical Index (TBI), Belin/Ambrósio Deviation (BAD-D), and KISA% index, with a cut-off value of 0.5, 0.79, 2.6 and 100, respectively, were employed to identify corneal ectasia.</p><p><strong>Results: </strong>Among 57 patients, 54.4% were diagnosed with vernal keratoconjunctivitis, 26.3% with seasonal allergic conjunctivitis, and 19.3% with atopic keratoconjunctivitis. The itching was the most common initial ocular symptom, followed by irritation and redness. The high-risk eyes for ectasia (based on CBI, TBI, BAD-D, and KISA%) were identified in 23.7%, 19.3%, 13.2%, and 7.9%, respectively. The ectatic group (determined by TBI) exhibited significantly higher mean curvature power (Km) (46.48±3.64 vs 43.10±1.31, p<0.001) and lower central corneal thickness (525.09±42.21 vs 561.20±30.91, p<0.001). However, there was no significant difference in the severity score of signs and symptoms between ectatic and non-ectatic groups. Isoametropic amblyopia was identified in 8.8% of patients, and anisometropic amblyopia was present in 1.8%.</p><p><strong>Conclusion: </strong>In ocular pediatric allergy, the risk of developing corneal ectasia is unrelated to the severity of signs and symptoms. Therefore, routine tomographic and biomechanical evaluations are recommended.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of pneumatic retinopexy in the Japanese population.","authors":"Kunihiko Akiyama, Takaaki Matsuki, Ken Watanabe, Aurora Pecaku, Sumana Naidu, Rajeev H Muni","doi":"10.1007/s10384-025-01241-z","DOIUrl":"https://doi.org/10.1007/s10384-025-01241-z","url":null,"abstract":"<p><strong>Purpose: </strong>To propose an implementation model for pneumatic retinopexy (PnR) in a region where PnR is performed infrequently, and to assess its impact on treatment of rhegmatogenous retinal detachment (RRD).</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>We reviewed 222 consecutive eyes with primary RRD treated from July 2017 to September 2023 at a tertiary care center in Japan. The treatment methods utilized included pars plana vitrectomy (PPV), scleral buckling (SB) and PnR. The surgeon learned PnR through social media. Primary anatomic reattachment rate (PARR) and visual acuity outcomes were compared between the pre-PnR (prior to the implementation; 110 eyes) and post-PnR (after the implementation; 112 eyes) periods, as well as between PnR and PPV in the post-PnR period. PARR for PnR was also evaluated based on RRD characteristics and gas injection frequency.</p><p><strong>Results: </strong>In the post-PnR period PnR was performed in 53.6% (60/112)of cases. The PARR was similar in the pre-PnR (97.3%) and post-PnR (93.8%) periods (P=.33). Visual outcomes were similar both across periods and between PnR and PPV at 3, 6 and 12 month post-operatively. The PARR for PnR was 88.3% overall, 90.5% in eyes meeting the Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT) criteria, 93.3% in eyes with a single break and 100% in eyes with a single break meeting PIVOT criteria. Eyes with a single gas injection had higher PARR than eyes requiring an additional gas injection (93.5% vs. 71.4%).</p><p><strong>Conclusion: </strong>Remote-learning utilizing social media effectively enabled PnR implementation with favorable anatomic and functional outcomes in a real-world setting in Japan.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-month comparative outcomes of aflibercept and faricimab in treatment-naïve macular edema secondary to branch retinal vein occlusion.","authors":"Taiichi Hikichi, Haruka Kurabe, Amane Notoya, Yuuna Oguro, Misaki Hirano, Yumeka Doi","doi":"10.1007/s10384-025-01254-8","DOIUrl":"https://doi.org/10.1007/s10384-025-01254-8","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the 6-month outcomes of aflibercept and faricimab in treatment-naïve macular edema secondary to branch retinal vein occlusion (BRVOME).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>The charts of consecutive treatment-naïve eyes with BRVOME treated with intravitreal injection therapy between December 2023 and August 2024 at Hikichi Eye Clinic (Sapporo, Japan) were reviewed; all eyes treated between December 2023 and April 2024 were administrated with aflibercept and all eyes treated between May 2024 and August 2024 were administrated with faricimab. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were assessed at baseline, 1, 3, and 6 months. Injection frequency and safety were also evaluated.</p><p><strong>Results: </strong>Fifty-four eyes (29 aflibercept, 25 faricimab) were included. Both groups showed significant improvement in BCVA (from 0.39 ± 0.29 to 0.09 ± 0.23) and CFT (from 617 ± 132 to 201 ± 68 µm) over 6 months (p < 0.001). The mean number of injections was significantly lower in the faricimab group (1.96 ± 0.68) than the aflibercept group (2.45 ± 0.87; p = 0.024). No serious adverse events were reported.</p><p><strong>Conclusion: </strong>Faricimab achieved similar visual and anatomical outcomes to aflibercept while requiring fewer injections, suggesting a potential advantage in reducing treatment burden.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal irregularity of the anterior and posterior surface in patients with limbal stem cell deficiency evaluated with anterior-segment optical coherence tomography.","authors":"Hiroki Goto, Takashi Ono, Yukako Taketani, Yuito Abe, Mikiko Kimakura, Tetsuya Toyono, Makoto Aihara, Takashi Miyai","doi":"10.1007/s10384-025-01242-y","DOIUrl":"https://doi.org/10.1007/s10384-025-01242-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate corneal anterior and posterior irregularities due to limbal stem cell deficiency (LSCD) based on staging using Fourier harmonic analysis with anterior segment optical coherence tomography (AS-OCT).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Patients with LSCD and those without anterior segment disease (controls), examined using AS-OCT, were retrospectively included. Based on Fourier harmonic analysis of the central 3 mm, spherical components, regular astigmatism, asymmetry components, and higher-order irregularities of the anterior, posterior, and total corneas were compared between the groups.</p><p><strong>Results: </strong>We analyzed 72 eyes of 72 patients-25 eyes of 25 patients (63.0 ± 15.8 years) with LSCD and 47 eyes of 47 patients (66.8 ± 9.5 years) in the control group. Regular astigmatism, asymmetry components, and higher-order irregularities of the anterior, posterior, and total corneas were higher in LSCD than in the control group (all P < 0.001). Based on LSCD staging, asymmetry components of the total cornea were higher in LSCD stages I, II, and III than in the controls (P = 0.034, P < 0.001, and P < 0.001, respectively). Additionally, higher-order irregularity was larger in stages II and III of LSCD than in the controls (all P < 0.001). The higher-order irregularity in LSCD significantly correlated with best-corrected visual acuity (P = 0.034).</p><p><strong>Conclusion: </strong>Corneal irregularities in the anterior and posterior corneas increased in patients with LSCD and contributed to best-corrected visual acuity. Even in patients at stage I, where the lesion spared the central 5 mm, an increase in asymmetric astigmatism within the central 3 mm was observed.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive strabismus surgery versus conventional surgical technique for inferior oblique recessions.","authors":"Tushit Dhar, Subhash Dadeya, Vaishali Tomar, Shipra Sharda, Shivani Kumari","doi":"10.1007/s10384-025-01249-5","DOIUrl":"https://doi.org/10.1007/s10384-025-01249-5","url":null,"abstract":"<p><strong>Purpose: </strong>Minimally invasive strabismus surgery (MISS) employs keyhole incisions to expose muscles and perform surgery. MISS has been found to yield better cosmetic outcomes after surgery involving horizontal recti. To further these findings, our study compared MISS for inferior oblique (IO) recession with conventional approach, in terms of complications and functional outcomes.</p><p><strong>Study design: </strong>Prospective Interventional study METHODS: Forty adult patients with inferior oblique overaction (IOOA) were randomly divided into two groups-those undergoing recession by MISS and those by conventional technique. MISS involved making a small radial cut over IO insertion, while in the conventional group recession was done via larger conjunctival incision. Main Outcome Measures included conjunctival injection, chemosis, periorbital edema and residual IOOA recorded during the first six postoperative weeks. Patients were followed up at postoperative day 1, day 7 and 6 weeks.</p><p><strong>Results: </strong>The mean age of patients was 21.17±3.43 years. The average recession performed was 9.5±0.98 mm (conventional: 9.4±1.14 mm; MISS: 9.6±0.82 mm; p>0.05). Conjunctival congestion (p<0.05) and periorbital edema (p<0.01) were significantly less in MISS than in the conventional group. There was also a significant difference in chemosis on postoperative days one and seven (p=0.00015 & 0.035 respectively). However, both groups had similar appearance at week six. No significant difference was found for final alignment and residual IOOA.</p><p><strong>Conclusion: </strong>This study shows that the MISS technique is feasible for inferior oblique recessions. It seems to be particularly superior in the immediate postoperative period, due to fewer conjunctival and periorbital swelling complications. Long-term results did not differ between the two groups.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced plasma oxytocin levels in patients with open-angle glaucoma.","authors":"Yurina Yamada, Kota Sato, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Naoki Kiyota, Naoki Takahashi, Yoko Takeda, Chiaki Yamaguchi, Kazuko Omodaka, Toru Nakazawa","doi":"10.1007/s10384-025-01248-6","DOIUrl":"https://doi.org/10.1007/s10384-025-01248-6","url":null,"abstract":"<p><strong>Purpose: </strong>We explored the role of oxytocin in glaucoma by measuring the blood levels of oxytocin in glaucoma patients, comparing them to normal control subjects, and examining its association with clinical parameters.</p><p><strong>Study design: </strong>Retrospective cross-sectional study.</p><p><strong>Material and methods: </strong>After obtaining informed consent from 181 glaucoma patients and 44 age-matched control participants, we collected blood samples in ethylenediaminetetraacetic acid (EDTA) tubes and centrifuged them at 2000 g for 25 minutes at 4 °C. The resulting plasma was assayed for oxytocin concentration with an Enzyme Linked Immunosorbent Assay (ELISA) kit. We compared oxytocin concentrations in the control and glaucoma groups, and within the glaucoma group, we determined whether the oxytocin levels were correlated with mean deviation (MD) and sectoral total deviation (TD). Furthermore, in 33 patients who underwent at least five visual field tests over a two-year period following oxytocin measurements and received no surgical interventions during that time, we determined whether the oxytocin levels were correlated with MD slope and sectoral TD slopes.</p><p><strong>Results: </strong>Oxytocin levels in glaucoma patients were significantly lower than in age- and sex-matched normal controls (723.34 ± 303.44 vs. 557.59 ± 296.04 pg/ml, p=0.002). In glaucoma patients, oxytocin levels were significantly correlated with MD and inferior TD after adjustment for age and sex (β=0.149, p=0.041; β=0.156, p=0.034, respectively). There was a weak negative correlation between oxytocin concentration and MD slope (β=-0.334, p=0.084) and a weak negative correlation with central TD slope (β=-0.405, p=0.039), adjusted for age, sex, and history of additional eye drops.</p><p><strong>Conclusion: </strong>Oxytocin concentrations in glaucoma patients were significantly lower than in normal subjects and associated with the severity and progression of visual field defects. Given the wide variety of the pharmacological actions of oxytocin, it may be involved in the pathogenesis of glaucoma. Our results suggest that plasma oxytocin measurements may open a new avenue for glaucoma care.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Japanese clinical guidelines for neovascular age-related macular degeneration.","authors":"Tomohiro Iida, Fumi Gomi, Tsutomu Yasukawa, Kenji Yamashiro, Shigeru Honda, Ichiro Maruko, Keiko Kataoka","doi":"10.1007/s10384-025-01240-0","DOIUrl":"https://doi.org/10.1007/s10384-025-01240-0","url":null,"abstract":"<p><p>Recent advances in imaging technology and increased options of pharmaceutical therapy require that guidelines on the diagnostic criteria and treatment of neovascular age-related macular degeneration (AMD) be updated at regular intervals. These guidelines aim to standardize the management of neovascular AMD based on the latest understanding of its pathophysiology, advancements in diagnostic imaging modalities, and treatment options. The key updates include: (1) a revision of terminology and stage classification, adopting the AMD classifications of atrophic and neovascular, and adding end-stage AMD to the existing early, intermediate, and late stages; (2) the inclusion of pachychoroid in addition to drusen in the initial pathophysiology and pathogenic background; (3) diagnostic criteria defined by the presence of macular neovascularization based on multimodal imaging, including optical coherence tomography (OCT) and OCT angiography; (4) assessment of disease activity based on OCT; and (5) treatment guidance, including prophylaxis and low vision care as well as loading and maintenance phases by use of anti-vascular endothelial growth factor therapy and adjunctive therapies. We hope that these guidelines will be useful for those working in clinical practice in Japan, in other Asian countries, and in countries outside Asia.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Retinal displacement using optical coherence tomography angiography and metamorphopsia in eyes undergoing macular hole surgery.","authors":"Shun Tsukahara, Asuka Takeyama, Masahiro Ishida","doi":"10.1007/s10384-025-01247-7","DOIUrl":"https://doi.org/10.1007/s10384-025-01247-7","url":null,"abstract":"","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loading phase outcomes of intravitreal aflibercept 8 mg for treatment-naïve neovascular age-related macular degeneration.","authors":"Hidetaka Matsumoto, Junki Hoshino, Saki Numaga, Yosuke Asatori, Hideo Akiyama","doi":"10.1007/s10384-025-01229-9","DOIUrl":"https://doi.org/10.1007/s10384-025-01229-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the efficacy and safety of loading phase treatment with 3 monthly intravitreal injections of aflibercept 8 mg for neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Retrospective, interventional case series.</p><p><strong>Methods: </strong>We retrospectively analyzed 83 consecutive eyes of 80 patients with treatment-naïve nAMD who received 3 monthly injections of aflibercept 8 mg as a loading phase treatment. Best-corrected visual acuity (BCVA), foveal thickness, central choroidal thickness (CCT), and dry macula achievement were all assessed every 4 weeks. Moreover, polypoidal lesion regression was evaluated after the loading phase.</p><p><strong>Results: </strong>Seventy eyes (84.3%) of 67 patients completed the 3 monthly injections of aflibercept 8 mg. In these cases, BCVA was 0.33±0.45 at baseline and showed significant improvement to 0.22±0.38 at week 12 (P<0.01). Foveal thickness was 313±135µm at baseline, decreasing significantly to 171±76µm at week 12 (P<0.01). CCT was 193±98µm at baseline, decreasing significantly to 160±85µm at week 12 (P<0.01). Dry macula had been achieved in 58 (82.9%) of 70 eyes at week 12. Indocyanine green angiography after the loading phase revealed complete polypoidal lesion regression in 16 of 22 eyes (72.7%) with polypoidal lesions. Among the 13 eyes (15.7%) not completing the loading phase treatment, 9 (10.8%) developed non-infectious intraocular inflammation (IOI) associated with retinal vasculitis and aflibercept 8 mg administration was thus discontinued.</p><p><strong>Conclusions: </strong>Loading phase treatment with intravitreal aflibercept 8 mg appears to be effective for improving visual acuity and ameliorating exudative changes in eyes with nAMD. However, careful monitoring is required due to the potential development of IOI associated with retinal vasculitis.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}