Japanese Journal of Ophthalmology最新文献

{"title":"Development of a smartphone-based retinal imaging device for stable fundus imaging.","authors":"Hidetoshi Maeda, Yoko Fukushima, Kakeru Sasaki, Yoshiyuki Kitaguchi, So Goto, Kohji Nishida","doi":"10.1007/s10384-026-01443-z","DOIUrl":"https://doi.org/10.1007/s10384-026-01443-z","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a smartphone-based imaging device and evaluate the operability and image acquisition performance.</p><p><strong>Study design: </strong>Prospective pilot study.</p><p><strong>Methods: </strong>A prototype device was developed, integrating a smartphone holder, a 28-diopter lens holder, and a neck strap. Sixteen examiners (nine ophthalmology residents and seven certified orthoptists) recorded the fundus videos of a healthy volunteer for 60 seconds using three methods: manual handheld, a commercially available non-medical smartphone holder, and our device. Each video was converted into 1,800 frames. Frames were judged as success if they met four criteria: inclusion of the optic disc and macula, fundus coverage > 75%, minimal artifacts, and sharp focus. The image acquisition rate (stability) and the shortest image acquisition time (usability) were compared among the three conditions.</p><p><strong>Results: </strong>The image acquisition rate was significantly higher with our device (31.49 ± 32.53%) compared to the manual handheld (5.31 ± 12.35%; P = 0.0024) and the commercial non-medical holder (3.68 ± 6.96%; P = 0.0057). The shortest image acquisition time was also significantly lower for our device (15.27 ± 24.03 s) than for the other two methods (handheld: 47.10 ± 21.44 s, P = 0.0078; commercial non-medical holder: 36.69 ± 27.29 s, P = 0.0080).</p><p><strong>Conclusion: </strong>The device demonstrates significantly improved stability and ease of use compared with conventional methods. Its design may help reduce operator dependency and facilitate fundus image acquisition in supine patients. Further validation in the intended clinical populations is warranted.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial corneal endothelial cell loss after preserflo microshunt implantation: association with tube insertion position.","authors":"Mitsuya Otsuka, Akio Miyakoshi, Yasuhito Nitta, Ryota Akai, Naoki Tojo, Atsushi Hayashi","doi":"10.1007/s10384-026-01439-9","DOIUrl":"https://doi.org/10.1007/s10384-026-01439-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate spatial corneal endothelial cell density (ECD) changes after PreserFlo MicroShunt^™ (PFM) implantation and identify tube-related factors associated with localized endothelial cell loss.</p><p><strong>Study design: </strong>Retrospective clinical study.</p><p><strong>Methods: </strong>This study included 118 eyes of 118 patients with medically refractory glaucoma who underwent PFM implantation and were followed for ≥6 months. Anterior-segment optical coherence tomography was used to evaluate tube-cornea distance, tube-cornea angle, and intracameral tube length. Gonioscopic images obtained 1 month postoperatively were used to classify tube insertion as iris-side, trabecular, or corneal-side. ECD was measured at nine corneal regions using specular microscopy. The primary outcome was the ECD reduction rate at the tube insertion site (Position 3) at 3 and 6 months. Linear mixed-effects models were used to identify factors associated with localized endothelial cell loss.</p><p><strong>Results: </strong>Tube insertion locations were iris-side in 36 eyes, trabecular in 73 eyes, and corneal-side in 9 eyes. In the primary linear mixed-effects analysis, compared with iris-side insertion, both trabecular-contact insertion (β = 12.8%, P = 0.026) and corneal-side insertion (β = 28.6%, P = 0.007) were associated with greater localized endothelial cell loss after multivariable adjustment. Central ECD reduction was mild (2.1% at 6 months).</p><p><strong>Conclusions: </strong>Early localized endothelial cell loss after PFM implantation was associated with tube insertion position, particularly corneal-side insertion. Central ECD measurements may underestimate localized endothelial cell loss.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical waste and greenhouse gas emissions in cataract surgery: a multicenter interventional study at ten Japanese hospitals.","authors":"Yoshitaka Takizawa, Hitoshi Tabuchi, Mao Tanabe, Keita Kihara, Masaki Miyoshi, Shoji Kuriyama, Riko Matsumoto, Masashi Fujiwara, Yasuo Kurimoto, Masayuki Shimizu, Kiyoshi Ishii, Masayuki Akimoto, Shinichiro Nakano, Yoshifumi Okamoto, Masaharu Iida, Gaku Kiuchi, Tetsuro Oshika","doi":"10.1007/s10384-026-01429-x","DOIUrl":"https://doi.org/10.1007/s10384-026-01429-x","url":null,"abstract":"<p><strong>Purpose: </strong>To quantify waste and greenhouse gas (GHG) emissions from disposable materials used in cataract surgery in Japan and to assess pragmatic, site-selected waste-reduction interventions.</p><p><strong>Study design: </strong>Prospective multicenter observational and interventional (before and after) clinical study.</p><p><strong>Methods: </strong>Ten Japanese sites audited 10 consecutive standard phacoemulsification cases at baseline and after implementing low-risk intervention selected by each site and integrated into routine workflow. Disposable items were collected and weighed. GHG emissions were estimated as a partial footprint attributable to disposable materials, expressed as carbon dioxide equivalents (CO₂eq), using published material emission factors and material-specific end-of-life assumptions. Primary outcomes were waste weight and GHG emissions per case.</p><p><strong>Results: </strong>A total of 201 surgical procedures were analyzed (100 baseline, 101 post-intervention). Baseline mean waste was 2.28 ± 0.40 kg and mean GHG emissions were 9.80 ± 2.14 kg CO₂eq per case; plastics were the largest contributor. Site-level medians decreased from 2.28 to 2.06 kg (P = .020) and from 9.09 to 8.35 kg CO₂eq (P = .004). In mixed-effects models, reductions did not reach statistical significance (waste ratio 0.86, 95% CI 0.73-1.02, P = .092; GHG ratio 0.84, 95% CI 0.71-1.00, P = .051).</p><p><strong>Conclusions: </strong>Cataract surgery in Japanese sites generates substantial disposable-material waste and associated CO₂eq. Pragmatic site-selected interventions were associated with significant reductions in site-summary analyses, while case-level modeling showed similar trends without statistical significance, suggesting heterogeneity and/or limited power.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subfoveal choroidal thickness across age and sex in a Korean population: insights from KNHANES 2017-2021.","authors":"Hyeong Min Kim, Seonghee Nam, Min Seok Kim","doi":"10.1007/s10384-026-01441-1","DOIUrl":"https://doi.org/10.1007/s10384-026-01441-1","url":null,"abstract":"<p><strong>Purpose: </strong>To establish a nationally representative normative reference dataset for subfoveal choroidal thickness (SFCT) in healthy eyes and to provide practical operational tools for interpreting individual SFCT measurements in clinical settings.</p><p><strong>Study design: </strong>Population-based cross-sectional study.</p><p><strong>Methods: </strong>We utilized data from participants in the Korea National Health and Nutrition Examination Survey 2017-2021 who underwent comprehensive ophthalmic examinations including SFCT measurements. Survey-weighted multivariable linear regression models were constructed to assess associations, with additional age- and sex-stratified analyses performed.</p><p><strong>Results: </strong>The normative reference cohort enrolled 27,965 participants. SFCT demonstrated a significant linear decrease with advancing age in OU (OD: β=-2.00, SE=0.12, P<0.001; OS: β=-1.84, SE=0.15, P<0.001) in multivariate models. Significant sex differences were observed in participants aged 30-39 years (OD: difference, -31.8 μm; 95% CI -48.6 to -15.0; P<0.001; OS: difference, -33.1 μm; 95% CI -51.1 to -15.1; P<0.001) and 40-49 years (OD: difference, -27.8 μm; 95% CI -33.6 to -22.1; P<0.001; OS: difference, -28.6 μm; 95% CI -34.8 to -22.4; P<0.001), and this difference diminished in older age groups.</p><p><strong>Conclusions: </strong>This study establishes a comprehensive normative reference framework for SFCT utilizing a nationally representative Korean population. These data may serve as reference values for evaluating choroidal structural changes in retinal and choroidal diseases.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digitalization of the diabetic eye notebook: patient and physician perspectives on a smartphone application for diabetic retinopathy management.","authors":"Shintaro Nakao, Kunihiko Hirosawa, Takao Hirano, Takenori Inomata, Junko Sato, Hirotaka Watada, Toshinori Murata, Motohiro Kamei","doi":"10.1007/s10384-026-01434-0","DOIUrl":"https://doi.org/10.1007/s10384-026-01434-0","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate patient and physician perspectives on the digitalization of the Diabetic Eye Notebook into a smartphone application, focusing on expectations, concerns, and potential benefits for the management of diabetic retinopathy (DR).</p><p><strong>Study design: </strong>A two-part prospective cross-sectional study comprising a multicenter patient survey and a single-center pilot usability and acceptability evaluation. (March-August 2024).</p><p><strong>Methods: </strong>Two independent surveys were conducted. In Study (A), 197 patients with diabetes from five institutions completed questionnaires assessing their awareness and use of the paper-based notebooks, willingness to adopt the application, and related expectations and concerns. In Study (B), a preliminary single-center pilot usability and acceptability evaluation was conducted in which eight physicians and ten patients at one institution used a beta version of the application and provided feedback on usability, functionality, and potential benefits.</p><p><strong>Results: </strong>In Study A: awareness and usage rates of the Diabetic Eye Notebook were 13.7 and 7.1%, respectively, both lower than those of the Japan Association for Diabetes Education and Care Coordination Notebook. Willingness to adopt the application was reported by 43.7% of patients. Patients willing to adopt the application were younger in the unadjusted comparison (mean age, 60.3 vs. 70.4 years; P<0.001), whereas the adjusted model showed a different direction for the age association, possibly reflecting confounding or a suppression effect related to routine smartphone-application use. Desired features included appointment reminders (47.3%), data sharing (32.2%), and visualization of clinical data (30.8%). Concerns included operational difficulty (64.4%) and data privacy (20.8%). In Study (B), physicians valued portability (75.0%) and improved communication (50.0%) but noted data entry burden (50.0%) and privacy issues (50.0%). Patients valued portability, treatment, history review, and improved communication (30.0% each), but reported privacy (40.0%) and usability (40.0%) concerns.</p><p><strong>Conclusion: </strong>This study identified key expectations and concerns among patients and physicians regarding the digitalization of the Diabetic Eye Notebook. Although the application has the potential to overcome practical limitations of the paper-based format, usability for older adults and data security remain major challenges, underscoring the need for further refinement and prospective evaluation.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between distance from the angle recess to the tube entry site and corneal endothelial cell loss after PreserFlo MicroShunt implantation.","authors":"Shunsuke Nishimura, Takahiro Minami, Sachiko Udagawa, Yoko Yamashita, Toshiya Suzuki, Takahiro Wada, Tomomi Higashide","doi":"10.1007/s10384-026-01442-0","DOIUrl":"https://doi.org/10.1007/s10384-026-01442-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between anterior segment optical coherence tomography (AS-OCT)-derived tube parameters and corneal endothelial cell density (ECD) changes after PreserFlo MicroShunt (PMS) surgery in primary open-angle glaucoma (POAG) and exfoliation glaucoma (XFG).</p><p><strong>Study design: </strong>Prospective cohort study.</p><p><strong>Methods: </strong>This study included pseudophakic patients with POAG or XFG who underwent PMS implantation. ECD was measured preoperatively and at 1, 3, 6, and 12 months post operatively, and every 6 months thereafter. Intracameral tube parameters, including tube position and length, were assessed using AS-OCT images obtained 1 month postoperatively. Associations between OCT parameters and the monthly rate of ECD change (ECD slope) were evaluated using linear mixed-effects models.</p><p><strong>Results: </strong>Mean preoperative ECD was 2384 ± 391 cells/mm². Mean follow-up period was 15 ± 7 months, with 5.1 ± 1.3 ECD measurements per eye. Tube parameters did not differ significantly between POAG (67 eyes of 61 patients) and XFG (18 eyes of 16 patients). The mean ECD slope was -11.8 ± 2.2 cells/mm²/month in XFG and -9.8 ± 1.1 cells/mm²/month in POAG (p = 0.38). A greater distance from the angle recess to the intracameral tube entry site was significantly associated with a more negative ECD slope in both XFG and POAG groups (p = 0.02 and 0.03). Its contribution to ECD slope variance was greater in XFG than in POAG (R² = 0.243 vs. 0.069).</p><p><strong>Conclusion: </strong>A longer distance from the angle recess to the intracameral tube entry site may predict accelerated ECD loss after PMS implantation, particularly in XFG.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral methotrexate as a steroid-sparing therapy after high-dose intravenous corticosteroid pulse therapy for refractory Vogt-Koyanagi-Harada disease.","authors":"Satoko Fujimoto, Kazuichi Maruyama, Takuya Shunto, Kohji Nishida","doi":"10.1007/s10384-026-01432-2","DOIUrl":"https://doi.org/10.1007/s10384-026-01432-2","url":null,"abstract":"<p><strong>Purpose: </strong>In Japan, high-dose corticosteroids serve as the first-line treatment for Vogt-Koyanagi-Harada disease (VKHD), whereas cyclosporine (CysA) and adalimumab are reserved for recurrent cases. However, some patients require prolonged corticosteroid therapy despite these immunosuppressants. Our institution generally utilizes CysA as the first-line steroid-sparing immunosuppressive agent and low-dose methotrexate (MTX; 6-8 mg/week) as a second-line or alternative therapy. We evaluated recurrence rates and treatment-related adverse effects, focusing on MTX.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>We reviewed 64 patients with first-onset VKHD treated with systemic corticosteroids (high-dose intravenous pulse therapy followed by oral prednisolone [PSL]) between April 2017 and April 2024. Recurrence was defined as the reappearance of intraocular inflammation after initial control. Clinical data regarding recurrence patterns and subsequent treatments, including MTX and CysA, were analyzed.</p><p><strong>Results: </strong>The cohort comprised 28 men and 36 women (mean age, 52.3 ± 15.4 years). Twenty-two of 64 patients (34%) experienced recurrence. Among these, 15 patients received CysA; 8 required switching to MTX because of insufficient disease control, difficulty tapering corticosteroids, or CysA-related adverse effects. After initiating MTX, six of eight patients discontinued PSL after a median of 17.5 months and remained recurrence-free during a median of 10 months. In contrast, among seven patients treated with CysA alone, five discontinued PSL after 34 months and remained recurrence-free for 24 months. No severe MTX-related adverse effects were observed.</p><p><strong>Conclusion: </strong>Low-dose MTX was well tolerated and enabled discontinuation of corticosteroids in patients with recurrent VKHD, supporting its utility as a feasible steroid-sparing therapy.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal age gap in unilateral retinal diseases with unaffected fellow eye: phakia and vascular pathology impact retinal age prediction.","authors":"Takumi Ando, Hiroko Terashima, Naoya Shiozaki, Katsumi Ando, Hiromitsu Yoshida, Yohei Nozaki, Takeo Fukuchi, Tadamichi Akagi","doi":"10.1007/s10384-026-01408-2","DOIUrl":"https://doi.org/10.1007/s10384-026-01408-2","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate retinal age gap (RAG), defined as the difference between the deep learning (DL)-predicted retinal age and chronological age, in five treatment-naïve unilateral retinal diseases and identify associated factors.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>This study included patients with unilateral retinal diseases who had unaffected fellow eyes. Individuals with bilaterally healthy eyes served as controls. Retinal age was estimated using the publicly available DL model. RAG was calculated by subtracting chronological age from predicted retinal age. We compared RAG among affected, fellow, and normal eyes. Multivariable linear mixed models identified covariates associated with RAG across the whole cohort of eyes.</p><p><strong>Results: </strong>Overall, 873 patients and 222 controls were analyzed. Prediction accuracy for retinal age was highest in normal (r = 0.90), followed by fellow (r = 0.70) and affected eyes (r = 0.54). Phakia (standardized β = -0.34), greater myopia (β = -0.08), and right-eye laterality (β = -0.05) were independently associated with higher RAG. Phakic eyes showed higher RAG than pseudophakic (0.8 ± 7.8 vs. -9.1 ± 10.6 years, p < 0.001). After multivariable adjustment of three covariates, higher RAG in affected eyes versus fellow eyes was observed only in retinal vein occlusion (RVO) (mean difference = 1.42 years, p = 0.037), particularly in central RVO (p = 0.001).</p><p><strong>Conclusions: </strong>Phakia had the strongest influence on RAG, warranting lens status considerations when developing or interpreting DL models. RAG may reflect retinal vascular pathology.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Six-month outcomes with a reduced two-injection induction (2+TAE) regimen of aflibercept 8 mg in treatment-naive neovascular age-related macular degeneration.","authors":"Nozomu Hashiya, Ichiro Maruko, Koji Tanaka, Junichiro Honjo, Yasunori Miyara, Yuto Watanabe, Ruka Maruko, Ayaka Nakai, Yu Wakatsuki, Kanako Itagaki, Marina Maehira, Nobuhiro Terao, Keiko Kataoka, Annabelle A Okada, Hideki Koizumi, Ryo Mukai, Tetsuju Sekiryu, Ryusaburo Mori, Tomohiro Iida","doi":"10.1007/s10384-026-01418-0","DOIUrl":"https://doi.org/10.1007/s10384-026-01418-0","url":null,"abstract":"","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing awareness toward genetic testing among patients with inherited retinal dystrophy in Japan.","authors":"Go Mawatari, Taiji Sakamoto, Koji M Nishiguchi, Masato Akiyama, Akio Oishi, Kaoru Fujinami, Akiko Maeda, Michikazu Nakai, Yasuhiro Ikeda","doi":"10.1007/s10384-026-01430-4","DOIUrl":"https://doi.org/10.1007/s10384-026-01430-4","url":null,"abstract":"<p><strong>Purpose: </strong>To conduct a nationwide questionnaire survey among patients with inherited retinal dystrophy (IRD) with the aim of investigating the percentage of patients requesting or not requesting genetic testing and clarifying the reasons underlying these preferences.</p><p><strong>Study design: </strong>A questionnaire-based cross-sectional study.</p><p><strong>Methods: </strong>This study conducted a questionnaire survey targeting IRD patients aged 18 years or older. Participants were recruited from members of the Japanese Retinitis Pigmentosa Society, a patient advocacy organization for individuals with retinitis pigmentosa and other IRDs, and collaborating research institutions. The study announcement was also posted on the website of the Department of Ophthalmology, Faculty of Medicine, University of Miyazaki. Responses were collected in print, e-mail, and online formats between October 1, 2023 and March 31, 2025. The resulting data were statistically analyzed using simple tabulation and a logistic regression analysis.</p><p><strong>Results: </strong>A total of 153 valid responses were obtained. The survey revealed that 86.3% of IRD patients requested genetic testing and the main reasons were personal motivation, such as: To identify the cause of the disease (84.8%), followed by: To obtain information for my future treatment, and :To obtain information regarding my future prognosis (both 81.8%). Conversely, the most common reason for not requesting the test was Genetic testing is pointless because there is no treatment (52.4%). Genetic testing was more likely to be requested by participants with greater knowledge of related terms. Among the 49 participants who had previously participated in gene analysis research, the explanation for the most frequent reason for satisfaction with the result was: The implications for children, grandchildren, and family members were clarified (73.7%), while the most frequent reason for dissatisfaction was: The diagnosis was not finalized (60.0%).</p><p><strong>Conclusion: </strong>The present results indicate that the majority of patients possess a high level of interest and a positive attitude toward genetic testing. It is crucial to properly convey the significance of genetic testing and related information to patients, which will enable more patients to approach genetic testing positively and achieve a high level of satisfaction.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}