Japanese Journal of Ophthalmology最新文献_第2页

Clinical performance of a hydrophobic acrylic toric intraocular lens with a double C-loop haptics in Japanese patients. 具有双c环触觉的疏水丙烯酸环人工晶状体在日本患者中的临床表现。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-29 DOI: 10.1007/s10384-025-01274-4

Yosai Mori, Kazunori Miyata, Takashi Kojima, Kazuo Ichikawa, Yoshifumi Fujita, Takuya Shiba, Hiroko Bissen-Miyajima

{"title":"Clinical performance of a hydrophobic acrylic toric intraocular lens with a double C-loop haptics in Japanese patients.","authors":"Yosai Mori, Kazunori Miyata, Takashi Kojima, Kazuo Ichikawa, Yoshifumi Fujita, Takuya Shiba, Hiroko Bissen-Miyajima","doi":"10.1007/s10384-025-01274-4","DOIUrl":"https://doi.org/10.1007/s10384-025-01274-4","url":null,"abstract":"Purpose: To evaluate the clinical performance of a hydrophobic acrylic toric intraocular lens (IOL) with double C-loop haptics in a Japanese population with cataracts.Study design: Prospective METHODS: The PODEYE TORIC IOL (POD T 49P) was implanted in 58 eyes from 42 patients diagnosed with bilateral cataracts with corneal astigmatism. Thirty-one eyes received IOLs with cylinder powers of 1.50 to 6.00 D (group A), and 27 eyes received IOLs with 1.00 D cylinder (group B). Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, and refractive cylinder were examined postoperatively. The primary endpoints, which were the non-inferiority of UDVA in group A and superiority of the refractive cylinder in group B, were examined and compared with relevant previous data.Results: In group A, the mean preoperative corneal astigmatism was 1.87±1.01 D and postoperative logMAR UDVA and CDVA were -0.023±0.110 and -0.102±0.079, respectively. There were 23 eyes (74.2%) with UDVA of 0.0 logMAR or better, while the refractive cylinder was - 0.39±0.39 D. In group B, the preoperative corneal astigmatism of 0.73±0.22 D and postoperative logMAR UDVA and CDVA were -0.074±0.091 and -0.096±0.075, respectively; 23 eyes (85.2%) obtained a UDVA of 0.0 logMAR or better. The postoperative refractive cylinder was -0.16±0.23D. The non-inferiority of UDVA in group A and the superiority of the refractive cylinder in group B were verified with previous data.Conclusion: The PODEYE TORIC IOL with 1.00-6.00 D cylinder powers and double C-loop haptics effectively corrected corneal astigmatism in Japanese patients after cataract surgery.Trial registration number: NCT04699266 (Clinicaltrials.gov).","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of corneal and anterior segment parameters in pediatric phenylketonuria. 儿童苯丙酮尿症角膜和前段参数的评价。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-26 DOI: 10.1007/s10384-025-01283-3

Sevim Ayça Seyyar, Gizem Gürbostan Soysal, Duhan Hopurcuoğlu

{"title":"Evaluation of corneal and anterior segment parameters in pediatric phenylketonuria.","authors":"Sevim Ayça Seyyar, Gizem Gürbostan Soysal, Duhan Hopurcuoğlu","doi":"10.1007/s10384-025-01283-3","DOIUrl":"https://doi.org/10.1007/s10384-025-01283-3","url":null,"abstract":"Purpose: To compare anterior segment parameters in healthy children of the same age with those in children with phenylketonuria (PKU).Study design: Retrospective observational study METHODS: Data from 25 eyes of PKU patients (study group) and 60 eyes of age- and gender-matched children (control group) were analyzed. The records reviewed included results from a comprehensive ophthalmic evaluation that each participant had previously undergone. This evaluation included refraction evaluation (spherical equivalent), best corrected visual acuity (BCVA) testing, slit-lamp biomicroscopy, fundus examination, intraocular pressure (IOP) measurement, specular microscopy, and corneal topography measurement.Result: Forty-five (52.9%) age- and sex-matched participants were girls and 40 (47.1%) were boys. The percentage of hexagonal cells (HEX) was 65.53±8.17 in the study group and 69.75±4.19 in the control group (p=0.021). Flat keratometry (K1) was 41.70±1.54 D in the study group and 43.16±1.52 D in the control group (p=0.002). Steep keratometry (K2) was 42.55±1.83 D in the study group and 43.91±1.73 D in the control group (p=0.013).Conclusion: This study shows that patients with pediatric PKU have differences in the anterior segment parameters, including keratometric values and HEX, when compared with healthy controls.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of a white cataract with elevated intralenticular pressure using an optical biometer based on swept-source optical coherence tomography. 基于扫描源光学相干断层扫描的光学生物计检测白色白内障伴晶状体内压升高。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-26 DOI: 10.1007/s10384-025-01284-2

Shota Kamei, Kouhei Hashizume, Junya Kizawa, Daijiro Kurosaka

{"title":"Detection of a white cataract with elevated intralenticular pressure using an optical biometer based on swept-source optical coherence tomography.","authors":"Shota Kamei, Kouhei Hashizume, Junya Kizawa, Daijiro Kurosaka","doi":"10.1007/s10384-025-01284-2","DOIUrl":"https://doi.org/10.1007/s10384-025-01284-2","url":null,"abstract":"Purpose: To determine whether a white cataract (WC) with elevated intralenticular pressure (EWC) can be distinguished from one with normal intralenticular pressure (NWC) using an optical biometer based on Swept-Source Optical Coherence Tomography (SS-OCT).Study design: Retrospective observational study METHODS: Patients with a WC who had undergone phacoemulsification and intraocular lens (IOL) implantation at Iwate Medical University Hospital were enrolled. Using surgical videos, WCs with/without leakage of the liquefied cortex or bulging of the swollen cortex were classified as EWC and NWC, respectively. Both groups were compared in terms of age, sex, ocular comorbidities, various parameters, and the presence of characteristic appearances of the liquefied cortex on SS-OCT images. If the parameters were not measured appropriately, remeasurement using SS-OCT images were performed.Results: Of the 48 patients with a WC, 26 eyes were classified as having an EWC, and 22 as NWC. There were significant differences in lens thickness (LT), anterior chamber depth (ACD), ΔLT, ΔACD (the differences in LT or ACD between the eyes with a WC and the fellow eyes, respectively), and age between an EWC and an NWC. ROC analysis showed that the AUC values of LT, ΔLT, and ΔACD were higher than 0.970. LT required remeasurement in approximately half of the WC, whereas ACD did not. Image evaluation for detecting an EWC had a sensitivity of 88.5% and a specificity of 90.9%.Conclusions: An optical biometer based on SS-OCT may detect an EWC using LT, ΔLT, ΔACD, and SS-OCT images.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting the treatment-requiring retinopathy of prematurity using birth weight, laboratory data and continuous peripheral capillary oxygen saturation monitoring. 利用出生体重、实验室数据和连续外周毛细血管血氧饱和度监测预测需要治疗的早产儿视网膜病变。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-15 DOI: 10.1007/s10384-025-01279-z

Taku Toyama, Han Peng Zhou, Gen Mihara, Kosuke Nakajima, Masako Nagahara, Kentaro Hayashi

{"title":"Predicting the treatment-requiring retinopathy of prematurity using birth weight, laboratory data and continuous peripheral capillary oxygen saturation monitoring.","authors":"Taku Toyama, Han Peng Zhou, Gen Mihara, Kosuke Nakajima, Masako Nagahara, Kentaro Hayashi","doi":"10.1007/s10384-025-01279-z","DOIUrl":"https://doi.org/10.1007/s10384-025-01279-z","url":null,"abstract":"Purpose: This single-center retrospective study aimed to identify independent predictors of retinopathy of prematurity (ROP) treatment by integrating continuous pulse oximetry (SpO₂) data with comprehensive laboratory parameters.Study design: Single-center retrospective cohort study.Methods: We analyzed 244 neonates (gestational age < 34 weeks or birth weight < 1800 g) admitted between 2019 and 2023, excluding those with major genetic abnormalities. Logistic regression assessed associations between birth weight (BW), average SpO₂ at birth, hemoglobin (Hb), albumin (Alb), and selected inflammatory markers (e.g., neutrophil-to-lymphocyte ratio) with ROP treatment. Model discrimination was evaluated via receiver operating characteristic curves.Results: Of the 244 infants, 16.8% required treatment (laser therapy or anti-VEGF injections). Lower BW and lower Hb were significantly associated with treatment (P <0.05). In the final multivariable model, BW and Hb emerged as key predictors (AUC = 0.884; accuracy = 88%), while Alb and inflammatory indices were not independently significant. Predicted treatment probabilities decreased markedly as BW and Hb increased.Conclusion: BW and Hb were primary predictors of ROP treatment necessity in this cohort, whereas Alb and inflammatory markers did not show independent associations. Incorporating continuous SpO₂ monitoring provided valuable respiratory insights. Further prospective, multicenter studies are warranted to validate these findings and refine ROP risk stratification strategies.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life after cultured corneal endothelial cell transplant in patients with bullous keratopathy. 大疱性角膜病变患者角膜内皮细胞移植后的生活质量。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-15 DOI: 10.1007/s10384-025-01280-6

Yuji Yamamoto, Yasufumi Tomioka, Kohsaku Numa, Hiroshi Tanaka, Kojiro Imai, Morio Ueno, Chie Sotozono, Shigeru Kinoshita

{"title":"Quality of life after cultured corneal endothelial cell transplant in patients with bullous keratopathy.","authors":"Yuji Yamamoto, Yasufumi Tomioka, Kohsaku Numa, Hiroshi Tanaka, Kojiro Imai, Morio Ueno, Chie Sotozono, Shigeru Kinoshita","doi":"10.1007/s10384-025-01280-6","DOIUrl":"https://doi.org/10.1007/s10384-025-01280-6","url":null,"abstract":"Purpose: Using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25), to evaluate vision-related quality of life outcomes in patients with bullous keratopathy after cultured corneal endothelial cell (CEC) transplant.Study design: Single-center prospective clinical trial METHODS: In this prospective, single-center study, 11 consecutive patients with bullous keratopathy underwent cultured CEC transplant. The NEI VFQ-25 was administered through in-person interviews by trained interviewers at baseline and at 24 weeks postoperatively. The NEI VFQ-25 comprises 12 subscales that assess different aspects of vision-related quality of life. Changes in composite and subscale scores were analyzed.Results: The patients comprised 5 men and 6 women, with a mean age of 64.4 years (range 49-82 years). All the patients had pseudophakic bullous keratopathy, with Fuchs endothelial corneal dystrophy being the predominant underlying cause of disease (7 eyes). The NEI VFQ-25 composite score improved significantly from 61.8 ± 11.9 to 79.5 ± 8.0 (P <.01). Significant improvements were observed in general vision, ocular pain, near vision, social function, mental health, role limitations, dependency, and peripheral vision subscales (P <.05). General health, distance vision, driving, and color vision subscales showed minimal improvement.Conclusions: Cultured CEC transplant significantly improved vision-related quality of life in patients with bullous keratopathy. The comprehensive improvement across multiple NEI VFQ-25 domains suggests that this novel therapeutic approach may be a viable treatment option for corneal endothelial dysfunction.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of optic disc abnormalities using retro-mode scanning laser ophthalmoscopy. 用反模式扫描激光检眼镜检测视盘异常。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-12 DOI: 10.1007/s10384-025-01260-w

Jianping Xiong, Shiqi Xie, Hongshuang Lu, Changyu Chen, Yining Wang, Ziye Wang, Koju Kamoi, Takeshi Yoshida, Shintaro Yasuda, Kyoko Ohno-Matsui

{"title":"Detection of optic disc abnormalities using retro-mode scanning laser ophthalmoscopy.","authors":"Jianping Xiong, Shiqi Xie, Hongshuang Lu, Changyu Chen, Yining Wang, Ziye Wang, Koju Kamoi, Takeshi Yoshida, Shintaro Yasuda, Kyoko Ohno-Matsui","doi":"10.1007/s10384-025-01260-w","DOIUrl":"https://doi.org/10.1007/s10384-025-01260-w","url":null,"abstract":"Purpose: To determine whether retro-mode scanning laser ophthalmoscopy (RMSLO) can detect optic disc abnormalities in highly myopic eyes.Study design: A retrospective clinical study.Methods: Patients with high myopia who had undergone RMSLO imaging and optic disc-centered optical coherence tomographic (OCT) examinations between July and September 2022 were studied. The existence and extent of the hyporeflective areas in the RMSLO images were determined. The OCT images were used to detect lamina cribrosa (LC) abnormalities, and the correspondence of the LC abnormalities to the location of the hyporeflective areas in the RMSLO images was determined.Results: Thirty-eight eyes of 21 patients with high myopia were studied. The mean age of the patients was 58.6±12.3 years, and the mean axial length was 30.54±1.96 mm. Hyporeflective areas were detected on the optic nerve head in the RMSLO images in 37 eyes (97.4%). In these 37 eyes, OCT detected defects of the LC and enlarged LC pores corresponding to the hyporeflective areas. The maximum width of the LC abnormalities in the OCT images corresponded to the extent of the hyporeflective areas in the RMSLO images.Conclusions: RMSLO can obtain images with hyporeflective areas on the optic disc in highly myopic eyes that correspond to areas of LC defects observed in the OCT images. RMSLO imaging can detect the enlarged LC pores as hyporeflective abnormalities. We conclude that RMSLO is helpful in detecting abnormalities of the LC of the optic disc.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between visual function and corneal backscatter by Scheimpflug imaging or anterior segment optical coherence tomography in Fuchs endothelial corneal dystrophy. Fuchs内皮性角膜营养不良患者视觉功能与Scheimpflug成像或前段光学相干断层扫描角膜后向散射的相关性

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-09 DOI: 10.1007/s10384-025-01223-1

Sayo Maeno, Yoshinori Oie, Takefumi Yamaguchi, Nozomi Nishida, Suzuka Doi, Chihomi Fujimoto, Sanae Asonuma, Takeshi Soma, Shizuka Koh, Naoki Okumura, Ryo Kawasaki, Vishal Jhanji, Naoyuki Maeda, Kohji Nishida

{"title":"Correlation between visual function and corneal backscatter by Scheimpflug imaging or anterior segment optical coherence tomography in Fuchs endothelial corneal dystrophy.","authors":"Sayo Maeno, Yoshinori Oie, Takefumi Yamaguchi, Nozomi Nishida, Suzuka Doi, Chihomi Fujimoto, Sanae Asonuma, Takeshi Soma, Shizuka Koh, Naoki Okumura, Ryo Kawasaki, Vishal Jhanji, Naoyuki Maeda, Kohji Nishida","doi":"10.1007/s10384-025-01223-1","DOIUrl":"https://doi.org/10.1007/s10384-025-01223-1","url":null,"abstract":"Abtract: PURPOSE: To evaluate the correlation between corneal backscatter and visual function in patients with Fuchs endothelial corneal dystrophy (FECD).Study design: Prospective case series.Methods: This study included 53 eyes from 38 patients with FECD. Corneal backscatter was quantified using light scattering (LS) via Scheimpflug imaging, and signal intensity (SI) via anterior segment optical coherence tomography. We measured corrected distance visual acuity (CDVA) using the Landolt-C and Early Treatment Diabetic Retinopathy Study (ETDRS) charts and contrast sensitivity function with sine wave grading chart by the area under the log contrast sensitivity function (AULCSF) and letter contrast sensitivity (LCS).Results: Significant correlations were observed between LS and SI, particularly in the posterior 60 μm of the central 0-2-mm cornea. LS in the central 6-mm cornea was significantly correlated with CDVA (Landolt-C and ETDRS) or contrast sensitivity (AULCSF and LCS) in most layers or diameters. In the central 0-2-mm cornea, LCS and posterior LS had the strongest correlation (ρ = -0.58, P < 0.01), followed by AULCSF and posterior LS (ρ = -0.55, P < 0.01). In the central 0.5-2-mm cornea, anterior or posterior SI demonstrated significant correlations with CDVA (Landolt-C and ETDRS) and contrast sensitivity (AULCSF and LCS). AULCSF and posterior SI had the strongest correlation (ρ = -0.58, P < 0.01), followed by LCS and posterior SI (ρ = -0.56, P < 0.01).Conclusion: The corneal backscatter of the anterior and posterior central cornea of FECD is significantly correlated with visual function across both imaging modalities.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of work-family conflict with turnover intention among hospital ophthalmologists in Japan: a cross-sectional study. 日本医院眼科医师工作家庭冲突与离职倾向之关系：横断面研究。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-08 DOI: 10.1007/s10384-025-01275-3

Yukiko Tsubota, Atsushi Miyawaki, Masashi Izumiya, Yuho Shimizu, Hideo Yasunaga, Makoto Aihara, Masato Eto

{"title":"Association of work-family conflict with turnover intention among hospital ophthalmologists in Japan: a cross-sectional study.","authors":"Yukiko Tsubota, Atsushi Miyawaki, Masashi Izumiya, Yuho Shimizu, Hideo Yasunaga, Makoto Aihara, Masato Eto","doi":"10.1007/s10384-025-01275-3","DOIUrl":"https://doi.org/10.1007/s10384-025-01275-3","url":null,"abstract":"Purpose: To examine the associations between work-family conflict, implicit gender bias, and turnover intention among hospital ophthalmologists.Study design: Cross-sectional study.Methods: We conducted a web-based questionnaire survey between January and February 2024. The participants were full-time ophthalmologists working in 37 hospitals in the Kanto region of Japan. We assessed the associations between work-family conflict, implicit gender bias, and turnover intention using multivariable regression analysis, with adjustments for job fit and position.Results: We analyzed data from 74 ophthalmologists (mean age: 41.5 years, standard deviation: 10.8; 51.4% women). The median intention to leave score was 2.50 (interquartile range: 2.00-3.00). Work interference with family was significantly associated with turnover intention (adjusted difference: 0.30; 95% confidence interval: 0.075-0.53; p=0.010). However, family interference with work and implicit gender bias were not significantly associated with turnover intention.Conclusions: This is the first study to examine the associations between work-family conflict, implicit gender bias, and turnover intention among Japanese hospital ophthalmologists. Work interference with family was associated with increased turnover intention but not with family interference with work or implicit gender bias.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence associated with 2-year visual acuity after subretinal tissue plasminogen activator for submacular hemorrhage in neovascular age-related macular degeneration. 视网膜下组织纤溶酶原激活剂治疗新生血管性年龄相关性黄斑变性患者黄斑下出血后2年视力复发率。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-08 DOI: 10.1007/s10384-025-01276-2

Mie Tanaka, Manabu Miyata, Masayuki Hata, Sotaro Ooto, Hiroshi Tamura, Ai Kido, Naoko Ueda-Arakawa, Masahiro Miyake, Ayako Takahashi, Yuki Muraoka, Akitaka Tsujikawa

{"title":"Recurrence associated with 2-year visual acuity after subretinal tissue plasminogen activator for submacular hemorrhage in neovascular age-related macular degeneration.","authors":"Mie Tanaka, Manabu Miyata, Masayuki Hata, Sotaro Ooto, Hiroshi Tamura, Ai Kido, Naoko Ueda-Arakawa, Masahiro Miyake, Ayako Takahashi, Yuki Muraoka, Akitaka Tsujikawa","doi":"10.1007/s10384-025-01276-2","DOIUrl":"https://doi.org/10.1007/s10384-025-01276-2","url":null,"abstract":"Purpose: To identify predictors of the 2-year best-corrected visual acuity (BCVA) after subretinal tissue plasminogen activator (tPA) injection for massive submacular hemorrhage (SMH) complicating neovascular age-related macular degeneration (nAMD).Study design: A prospective, observational study.Methods: This study included consecutive eyes with massive SMH and nAMD that underwent vitrectomy with subretinal tPA injection and follow-up for 2 years. We analyzed the correlation between the 2-year BCVA and other parameters, including baseline BCVA, SMH height, SMH size, and SMH recurrence.Results: This study analyzed 20 eyes of 20 patients (72.5 ± 7.2 years). Two years after surgery, the mean logarithm of the minimum angle of resolution (logMAR) BCVA changed from 0.72 (Snellen equivalent, 20/105) ± 0.40 at baseline to 0.80 (Snellen equivalent, 20/126) ± 0.92. The BCVA did not change significantly during the 2-year observation period (P = 0.39). Compared to baseline, the 2-year BCVA improved in 11 eyes (55%) and declined in 6 eyes (30%) by more than 0.30 logMAR, including all five eyes with recurrence. The 2-year BCVA was correlated only with recurrence (P < 0.001, β = 0.85).Conclusions: This study suggests that recurrence was a robust determinant of poor 2-year BCVA after vitrectomy with subretinal tPA injection for SMH complicating nAMD and that subretinal tPA injection was effective in most cases, without recurrence. Our findings highlight the importance of establishing methods for preventing and controlling recurrence to maintain long-term BCVA.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rescue pneumatic retinopexy for recurrent retinal detachments due to superior retinal breaks following initial vitrectomy. 玻璃体切除术后因上视网膜破裂而复发性视网膜脱离的抢救充气视网膜固定术。

IF 1.9 3区医学

Japanese Journal of Ophthalmology Pub Date : 2025-09-08 DOI: 10.1007/s10384-025-01278-0

Jun Takeuchi, Takashi Koto, Makoto Inoue

{"title":"Rescue pneumatic retinopexy for recurrent retinal detachments due to superior retinal breaks following initial vitrectomy.","authors":"Jun Takeuchi, Takashi Koto, Makoto Inoue","doi":"10.1007/s10384-025-01278-0","DOIUrl":"https://doi.org/10.1007/s10384-025-01278-0","url":null,"abstract":"Purpose: To evaluate the clinical outcomes of pneumatic retinopexy (PnR) for a recurrent rhegmatogenous retinal detachment (RRD) due to superior retinal breaks following initial vitrectomy for a RRD.Study design: Clinical investigations.Methods: A retrospective study of 82 eyes of 82 patients who underwent vitrectomy by a single surgeon between November 2021 and March 2023. PnR was performed on 4 (4.9%) of 11 eyes that developed a recurrent RD. The PnR procedure involved injecting sulfur hexafluoride gas into the vitreous cavity while the patient was in the lateral or in the supine position. The patient was placed in the prone position after the injection, and then laser photocoagulation was performed.Results: A retinal reattachment was achieved in all four eyes that underwent rescue PnR. The gas infusion volume during the PnR was 4.3 to 5.6 ml for cases in which PnR was performed in the lateral position and 1.0 ml for a case in the supine position. The duration of the gas tamponade was 15 to 21 days for patients who had PnR in the lateral position and 11 days for patients who had PnR in the supine position. The best-corrected visual acuity after the treatment improved in all patients. No serious complications were associated with the PnR.Conclusion: The results indicate that rescue PnR may be an effective treatment for a recurrent RRD due to superior retinal breaks after vitrectomy for a RRD to achieve retinal reattachment without reoperation or hospitalization.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0