Japanese Journal of Ophthalmology最新文献

{"title":"Age-related difference in the presbyopia-correcting effect of trifocal and enhanced monofocal intraocular lenses.","authors":"Ken Hayashi, Koichi Uno, Shunsuke Hayashi, Motoaki Yoshida","doi":"10.1007/s10384-025-01245-9","DOIUrl":"https://doi.org/10.1007/s10384-025-01245-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare visual outcomes among three age groups in eyes with a trifocal (Alcon PanOptix^®) or enhanced monofocal intraocular lens (IOLs; Johnson & Johnson Eyhance^®).</p><p><strong>Study design: </strong>Nonrandomized comparative study.</p><p><strong>Methods: </strong>Seventy-eight eyes of 78 patients who received a trifocal IOL (trifocal category) and 78 eyes of 78 patients who received an enhanced monofocal IOL (enhanced monofocal category) were enrolled. Patients were stratified by age decade (n=26/group): 40-59 years of age (40s & 50s), 60-69 years of age (60s), and 70-79 years of age (70s). Uncorrected and distance-corrected visual acuity (VA) at various distances and photopic and mesopic contrast VA were examined at 3 months postoperatively and compared among age groups.</p><p><strong>Results: </strong>No significant differences in the mean uncorrected and distance-corrected VAs were detected at nearly all distances among the three age groups for either the trifocal or enhanced monofocal category. Mean photopic contrast VA was significantly different among the three age groups at 100% contrast for the trifocal category (P=0.018) and at 25%, 10%, 5%, and 2.5% contrasts in the enhanced monofocal category (P≤0.005); it was significantly better in the 40s & 50s age group than in the 60s or 70s age group (P≤0.002).</p><p><strong>Conclusion: </strong>All-distance VA in eyes with a trifocal IOL and an enhanced monofocal IOL was essentially comparable among patients 40-79 years of age although contrast sensitivity was significantly worse in older patients, suggesting that these IOLs can be implanted irrespective of patient age with careful consideration of the age-dependent decline in contrast sensitivity.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo characterization of morphologic changes in the lens during accommodation as a function of age by use of OCT with swept-source technology.","authors":"Mario Cantó-Cerdán, Ana Siverio-Colomina, Pilar Yébana-Rubio, Maria José García-Corral, Zaíra Cervera-Sánchez, Antonio Martínez-Abad","doi":"10.1007/s10384-025-01244-w","DOIUrl":"https://doi.org/10.1007/s10384-025-01244-w","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the in vivo morphologic and biometric changes in the lens during accommodation as a function of age by use of swept-source OCT technology STUDY DESIGN: Observational, prospective study METHODS: Complete optometric and ophthalmologic examinations were performed on all the patients to determine their eligibility for inclusion in the study. The examinations included anterior segment measurements obtained using swept-source OCT. Morphologic parameters of the lens were analysed under accommodative stimuli of 0, -1, -2, -3, and -6 D. A second measurement was taken 10 minutes after the first.</p><p><strong>Results: </strong>Three hundred eyes of 300 patients were enrolled in the study. Structural changes in the lens were observed, specifically in the anterior and posterior radii, which decreased with accommodation, and the total thickness of the lens, which increased. In patients aged younger than 40 years, significant changes were found in the curvature radius and lens thickness during accommodation. In patients aged older than 40 years, these changes began to diminish. Significant differences between stimuli (P <.05) were observed in all the groups, demonstrating lens variation during accommodation and its dependence on age. Repeatability analysis showed an intraclass correlation coefficient of >0.700 for all the parameters.</p><p><strong>Conclusions: </strong>During accommodation, the anterior and posterior curvatures of the lens decrease, while its thickness increases. Age-related differences remained significant, indicating persistent changes over time. Swept-source OCT demonstrated high repeatability, particularly for anterior curvature, thickness, and tilt, even under accommodation.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of no-history formulae for intraocular lens power calculation in post-myopic laser vision correction eyes: a multicenter study in Japan.","authors":"So Goto, Yosai Mori, Hidemasa Torii, Yumi Hasegawa, Takashi Kojima, Kazutaka Kamiya, Takuya Shiba, Kazunori Miyata","doi":"10.1007/s10384-025-01217-z","DOIUrl":"https://doi.org/10.1007/s10384-025-01217-z","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the refractive prediction accuracy of seven no-history intraocular lens (IOL) power calculation formulas in post-myopic laser vision correction (M-LVC) eyes in Japanese patients.</p><p><strong>Study design: </strong>Multicenter retrospective case series.</p><p><strong>Methods: </strong>This study included patients with previous M-LVC who underwent cataract surgery between 2016 and 2023. IOL power calculation formulas were assessed using measurements from a swept-source optical coherence biometer. Refractive prediction errors were calculated for the Emmetropia Verifying Optical 2.0 (EVO 2.0), Post Myopic LASIK/PRK Hoffer QST (Hoffer QST), and Post-M-LVC PEARL-DGS (PEARL-DGS) formulas. These results were compared with those obtained from the Barrett True-K No History (BTKNH), Haigis-L, Shammas, and ASCRS average formulas. Heteroscedastic testing for root mean square absolute error (RMSAE) was used to evaluate formula performance.</p><p><strong>Results: </strong>The study comprised 125 post-LASIK eyes from 89 patients. Only the BTKNH had mean numerical errors not significantly different from zero. The formulas were ranked by absolute prediction error (MAE): ASCRS average (0.42 D), BTKNH (0.43 D), Hoffer QST (0.46 D), Pearl-DGS and Shammas (0.46 D), EVO 2.0 (0.48 D), and Haigis-L (0.51 D). The BTKNH and ASCRS average demonstrated smaller RMSAE compared to Shammas (P < .0001). The Hoffer QST had a smaller RMSAE than Pearl-DGS (P = 0.02).</p><p><strong>Conclusion: </strong>The BTKNH, ASCRS average, and Hoffer QST formulas are precise and reliable for improving postoperative refractive outcomes in Japanese patients with a history of M-LVC.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effect of ripasudil on retinal ganglion cells via an antioxidative mechanism.","authors":"Reiko Yamagishi-Kimura, Megumi Honjo, Makoto Aihara","doi":"10.1007/s10384-025-01243-x","DOIUrl":"https://doi.org/10.1007/s10384-025-01243-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the neuroprotective effect of ripasudil, a rho-kinase inhibitor that is a commercially available glaucoma medication that lowers intraocular pressure. We explored the effects of ripasudil on retinal damage via oxidative stress (OS) in primary rat retinal ganglion cell (RGC) cultures and NMDA-induced retinal damage in mice.</p><p><strong>Study design: </strong>Experimental investigation METHODS: Primary rat RGCs were isolated via a 2-step immunopanning method and cultured under normal cultivation conditions for 72 h and for a further 24 h in antioxidant-free medium for OS. We measured the number of living RGCs by use of calcein-AM and calpain activity via calpain immunoreactivity assays. Furthermore, we evaluated the effects of ripasudil via RGC counting in retinal flat-mounts from Thy1-CFP mice, retinal thickness via optical coherence tomography, and reduced glutathione levels via GSSG/GSH assays in NMDA-induced retinal damage.</p><p><strong>Results: </strong>The living RGC counts of normal, OS, 0.1, 1, 10, and 100 uM ripasudil under OS were 236.0 ± 21.6, 155.0 ± 13.2, 155.9 ± 17.1, 158.9 ± 12.0, 184.8 ± 26.9, and 201.1 ± 24.8 cells, respectively. 10 or 100 uM ripasudil significantly inhibited the OS-induced RGC reduction (P < 0.05 or 0.01). Furthermore, the enhanced calpain activity induced by OS was suppressed by 100 uM ripasudil (P < 0.05). In an in vivo study, the RGC counts in the NMDA-treated group were lower than those of the non-NMDA-treated group. NMDA-induced RGC loss was significantly suppressed by ripasudil (P < 0.01). Retinal thinning after 3 weeks of NMDA injection was also inhibited by ripasudil (P < 0.01 or 0.05). Furthermore, NMDA increased the glutathione level, whereas ripasudil suppressed it (P < 0.05).</p><p><strong>Conclusions: </strong>Ripasudil may have neuroprotective effects via an antioxidative mechanism, which could be useful as an intraocular pressure-independent additive.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic nerve MRI findings in Leber's hereditary optic neuropathy.","authors":"Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1007/s10384-025-01246-8","DOIUrl":"https://doi.org/10.1007/s10384-025-01246-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the characteristics of magnetic resonance imaging (MRI) of lesions in Lebers hereditary optic neuropathy (LHON).</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>We examined the clinical characteristics and MRI scans of lesion locations in 34 LHON cases (68 eyes) with m.11778G>A mutation, examined within six months of onset who had detailed MRI imaging records available.</p><p><strong>Results: </strong>The median age was 36.5 (range: 10-75) years, with 26 male cases. MRI lesions were observed in 15 cases, with the following distribution: isolated intraorbital lesions in 7 cases, intraorbital + optic canal lesions in 1 case, intraorbital + optic canal + intracranial lesions in 1 case, optic canal + intracranial lesions in 1 case, optic canal + intracranial + chiasmal lesions in 1 case, intracranial + chiasmal lesions in 3 cases, and chiasmal + optic tract lesions in 1 case. There were no significant differences in clinical characteristics between patients with and without MRI lesions. Cases with chiasmal lesions tended to be younger (chiasmal lesion group [n=5] vs. non-chiasmal lesion group [n=29]: median age 25 [range: 11-30] years vs. 44 [range: 10-75] years, p=0.02, Mann-Whitney U test), although there were no significant differences in sex or time to MRI imaging.</p><p><strong>Conclusion: </strong>MRI lesions can extend from the intraorbital optic nerve to the chiasm and tract. Consistent with previous reports, chiasmal involvement was frequently observed and was more prevalent in younger patients. Recognition of these characteristic MRI and clinical findings is crucial in the differential diagnosis of subacute progressive optic neuropathy.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short‑term outcomes of switching to faricimab for macular edema secondary to retinal vein occlusion.","authors":"Taiichi Hikichi, Haruka Kurabe, Amane Notoya, Yuuna Oguro, Misaki Hirano, Yumeka Doi","doi":"10.1007/s10384-025-01237-9","DOIUrl":"https://doi.org/10.1007/s10384-025-01237-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the anatomical and functional outcomes in patients with macular edema (ME) secondary to retinal vein occlusion (RVO) who were switched from conventional anti-vascular endothelial growth factor (VEGF) agents to faricimab.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>This study included 42 eyes from 42 patients treated at Hikichi Eye Clinic between April and August 2024. All patients had relapsed ME despite prior treatment with aflibercept and were switched to intravitreal faricimab (6.0 mg). The primary endpoints included best-corrected visual acuity (BCVA), central foveal thickness (CFT), and intravitreal injection intervals over six months.</p><p><strong>Results: </strong>The mean (± standard error) CFT significantly decreased from 356 ± 23 μm to 214 ± 3 μm at one month (p < 0.01) and remained stable at the final visit (205 ± 4 μm). Logarithm of the minimum angle of resolution (logMAR) BCVA improved from 0.16 ± 0.03 to 0.04 ± 0.03 at one month (p < 0.01) and remained at 0.02 ± 0.02 at the final visit. The mean injection interval was significantly extended from 12.3 ± 0.4 weeks to 16.2 ± 0.5 weeks (p < 0.01).</p><p><strong>Conclusion: </strong>Faricimab improved anatomical and functional outcomes while extending treatment intervals in ME secondary to RVO. Further large-scale, prospective, and long-term follow-up studies are needed to confirm these findings.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of SIX6 gene in juvenile open-angle glaucoma: a subtle contributor to the mutational landscape.","authors":"Manoj Yadav, Sumit Sachdeva, Anshu Yadav, Aarti Bhardwaj, Vishal Panghal, Ankit Kumari, Ritu Yadav, Rakesh Kumar, Mayank Singh, Sapna Sharma, Mukesh Tanwar","doi":"10.1007/s10384-025-01233-z","DOIUrl":"https://doi.org/10.1007/s10384-025-01233-z","url":null,"abstract":"<p><strong>Purpose: </strong>Juvenile onset open-angle glaucoma (JOAG) typically affects individuals under 40 years of age, causing a rise in intraocular pressure that results in considerable damage to the optic nerve. To expand the spectrum of mutations linked to JOAG and explore their structural consequences, we examined the genetic alterations within the SIX6 gene.</p><p><strong>Study design: </strong>We focused on assessing the whole coding region of the SIX6 gene and the clinical significance of the common SIX6 gene single nucleotide polymorphisms (SNP) rs10483727 and rs33912345, specifically analyzing its association with key clinical factors, including intraocular pressure (IOP), visual acuity, and the vertical cup-to-disc ratio (VCDR).</p><p><strong>Method: </strong>The study included 111 unrelated patients with confirmed JOAG and 100 healthy adult controls without any ocular or systemic conditions. The patients initially underwent genetic screening for pathogenic variants in the CYP1B1, MYOC, and OPTN genes. Individuals who tested negative for pathogenic variants in these three genes (n=81) were subsequently screened for variants in the SIX6 gene while all 111 patients and 100 control samples were screened for SNPs to strengthen the statistical correlation. Identified sequence variations were searched in the ClinVar databases, HGMD, and dbSNP. Six different online available algorithms including REVEL, SIFT, CADD, Mutation Taster, IMutant2.0, and MetaLR were used for the pathogenicity prediction of missense variations. The Structural consequences of detected possible pathogenic variations were predicted by using PyMol, Chimera and molecular dynamics (MD) simulation of these changes. Statistical analyses assessed the association of rs33912345 with disease phenotypes.</p><p><strong>Results: </strong>Sanger sequencing identified seven nucleotide variants in the SIX6 gene, including five missense and two synonymous variants. Two missense variants, p.(A99G) and p.(S156R), were predicted to be pathogenic. The novel variant p.(A99G) was absent in controls and demonstrated significant structural disruption, with altered intramolecular interactions and steric clashes. Homology analysis revealed high evolutionary conservation at the mutated positions, highlighting their functional significance. MD simulations confirmed altered stability in the mutant proteins. Logistic regression linked rs33912345 to JOAG, with significant associations observed for IOP (p = 0.01538), and VCDR (p = 0.019).</p><p><strong>Conclusion: </strong>This study identified novel and known pathogenic variants in the SIX6 gene that may contribute to JOAG pathogenesis. Structural and functional analyses suggest that these mutations disrupt protein function. The findings enhance our understanding of JOAG genetics and may aid in early diagnosis and therapeutic targeting.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of intraocular pressure elevation following intravitreal injection of 70 µl aflibercept 8 mg.","authors":"Xien Lu, Keiko Kataoka, Mariko Kumagai, Yuta Nochi, Akiko Yamamoto, Rie Ko, Annabelle A Okada","doi":"10.1007/s10384-025-01239-7","DOIUrl":"https://doi.org/10.1007/s10384-025-01239-7","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effect of increased injection volume on intraocular pressure (IOP) following intravitreal injections of aflibercept 8 mg (70 µl) compared to conventional anti-vascular endothelial growth factor drugs.</p><p><strong>Study design: </strong>Retrospective observational study METHODS: This retrospective observational study included eyes treated with 50 µl of either aflibercept 2 mg or faricimab 6 mg, followed by a switch to 70 µl of aflibercept 8 mg. IOP was measured before and 30 minutes after intravitreal injections. IOP changes in treated and fellow eyes were analyzed, with potential associations examined between IOP changes and clinical parameters.</p><p><strong>Results: </strong>A total of 88 eyes from 85 patients were switched to aflibercept 8 mg during the study period. Due to incomplete data, 17 eyes from 15 patients were excluded, leaving 71 eyes from 70 patients for the analysis. IOP significantly increased from 13.2 ± 2.9 mmHg to 19.1± 5.4 mmHg (P< 0.001) with 50 µl injections and from 13.3 ± 2.9 mmHg to 19.8 ± 4.8 mmHg (P<0.001) with 70 µl injections. The IOP increases were 6.0 ± 5.0 mmHg with 50 µl injections and 6.5 ± 4.3 mmHg with 70 µl injections, with no statistically significant difference (P = 0.20). An IOP exceeding 26 mmHg was observed in 6 eyes treated with 50 µl injections and 10 eyes with 70 µl injections, with no significant difference in IOP distribution between the volumes (P = 0.20).</p><p><strong>Conclusion: </strong>There was no additional increase in IOP 30 minutes after intravitreal injections when switching from 50 µl to 70 µl volumes.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of a randomised trial comparing 360° and 180° schlemm's canal incisions in suture trabeculotomy ab interno for primary open-angle glaucoma and exfoliation glaucoma: a 5-year analysis.","authors":"Tomoki Sato, Takahiro Kawaji","doi":"10.1007/s10384-025-01236-w","DOIUrl":"https://doi.org/10.1007/s10384-025-01236-w","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to report the 5-year efficacy and safety data of suture trabeculotomy ab interno (SLOT ab interno) in patients with primary open-angle glaucoma and exfoliation glaucoma.</p><p><strong>Study design: </strong>Single-centre, three-arm randomised trial.</p><p><strong>Methods: </strong>Ninety-nine eyes of 99 patients were randomly assigned to one of three groups: the 360° (n = 34), upper-180° (n = 34), and lower-180° (n = 31) groups. We evaluated intraocular pressure (IOP), medication use, and visual field progression. Surgical success (with or without medication) was defined as IOP ≤21 mmHg with a ≥20% reduction (criterion A) or IOP ≤15 mmHg with a ≥ 20% reduction (criterion B). Visual field progression was assessed by MD values at fixed postoperative time points and by the MD slope (dB/year).</p><p><strong>Results: </strong>Fifty-six of 99 eyes (56.5%) completed 5 years of follow-up. At 5 years, the mean IOP decreased from 18.8 ± 5.7 to 13.5 ± 3.1 mmHg (28% reduction, p<0.001), with medication use decreasing from 3.3 ± 1.1 to 2.0 ± 1.7 (p=0.005) and a mean MD slope of -0.2 dB/year. No significant differences in surgical success rates (criteria A and B), MD values, or MD slopes were observed among the groups.</p><p><strong>Conclusion: </strong>The extent of Schlemm's canal incisions (360°, upper-180°, or lower-180°) during SLOT ab interno has no significant effect on IOP reduction or medication use over 5 years.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsideration of conversion to multiple sclerosis: one-year cerebral lesion appearance rate of Japanese aquaporin-4 antibody-negative optic neuritis patients.","authors":"Satoshi Ueki, Yukari Hasegawa, Tetsuhisa Hatase, Izumi Kawachi, Takeo Fukuchi","doi":"10.1007/s10384-025-01235-x","DOIUrl":"10.1007/s10384-025-01235-x","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the rate of new cerebral lesions' appearance within 6-12 months in Japanese optic neuritis patients who at onset had no cerebral lesions suggestive of multiple sclerosis (MS) and were negative for aquaporin-4 (AQP4) antibodies.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>Medical records of 66 adult patients with optic neuritis were reviewed. Patients positive for AQP4, myelin oligodendrocyte glycoprotein, or antinuclear antibodies were excluded. Those without cerebral lesions on initial magnetic resonance imaging (MRI) underwent follow-up MRI within 6-12 months. Clinical characteristics and subsequent neurological diagnoses were analyzed.</p><p><strong>Results: </strong>Forty-seven patients met the inclusion criteria (mean age, 41.9±16.7 years; 13 men, 34 women). Forty-two cases were unilateral, five bilateral; 19 had disc swelling, and 28 did not. The mean worst logMAR was 1.13±0.96. Two patients experienced recurrence within 1 year. Of the 27 patients without initial cerebral lesions, 20 underwent follow-up MRI; 3 (15%) developed new lesions. These three were later diagnosed as two MS and one suspected MS cases.</p><p><strong>Conclusion: </strong>Follow-up MRI within 6-12 months revealed new cerebral lesions in 15% of patients, with 10% diagnosed with MS. This highlights the importance of follow-up imaging even in AQP4 antibody-negative optic neuritis patients without initial cerebral lesions, especially in the absence of other diseases like neuromyelitis optica spectrum disorders.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}