Japanese Journal of Ophthalmology最新文献

{"title":"Factors predictive of treatment outcomes in submacular hemorrhage secondary to age-related macular degeneration.","authors":"Yuto Watanabe, Takashi Koto, Aya Takahashi, Masaharu Mizuno, Tomoka Ishida, Kosuke Nakajima, Jun Takeuchi, Tadashi Yokoi, Makiko Nakayama, Annabelle A Okada, Makoto Inoue, Keiko Kataoka","doi":"10.1007/s10384-025-01207-1","DOIUrl":"https://doi.org/10.1007/s10384-025-01207-1","url":null,"abstract":"<p><strong>Purpose: </strong>To identify predictors for visual outcomes of eyes with submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Clinical data from patients diagnosed with SMH secondary to nAMD and treated with pneumatic displacement were collected. SMH thickness was measured by optical coherence tomography (OCT) at baseline and 1 week. Possible factors associated with best-corrected visual acuity (BCVA) gain at 3 months were analyzed.</p><p><strong>Results: </strong>Fifty-six eyes of 56 patients (18 female/38 male; mean age, 77.8 ± 10.1 years) were analyzed; 34 were treatment-naïve and 22 were previously treated with anti-vascular endothelial growth factor agents. Multivariable analysis showed that greater BCVA gain more than 0.3 logMAR at 3 months post-treatment was associated with being treatment-naïve (odds ratio [OR], 34.30; 95% confidence interval [CI], 1.38-851.91; P = 0.031), thinner SMH thickness at 1 week after pneumatic displacement (OR, 0.38 per 50-unit increase; CI, 0.18-0.80; P = 0.011), and worse baseline BCVA (OR, 2.58 per 0.1-unit increase; CI, 1.31-5.07; P = 0.006), but not associated with age (OR, 0.50; 95% CI, 0.24-1.06), the time from onset to pneumatic displacement (OR, 1.04; 95%CI, 0.87-1.23), SMH thickness at baseline (OR, 0.92; 95%CI, 0.63-1.36), and the presence of subfoveal hemorrhagic PED (OR, 0.72; 95%CI, 0.08-6.84).</p><p><strong>Conclusion: </strong>This study identifies novel factors predictive of visual outcomes for pneumatic displacement for SMH due to nAMD. The presence of residual SMH at 1 week following unsuccessful pneumatic displacement may warrant further intervention.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of changes in retinal light sensitivity thresholds in the early postoperative days after trabeculectomy using microperimetry.","authors":"Takeshi Yoshida, Sho Ogawa, Takayuki Miki, Yuiko Kodera, Gen Shimizu, Sota Yoshimoto, Keigo Sugisawa, Motohisa Ohno, Shintaro Yasuda, Yuto Shiotani, Kyoko Ohno-Matsui","doi":"10.1007/s10384-025-01186-3","DOIUrl":"https://doi.org/10.1007/s10384-025-01186-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate early postoperative changes in retinal light sensitivity at the foveal and paramacular points in open angle glaucoma patients.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>Twenty-four eyes undergoing trabeculectomy were analyzed. Retinal light sensitivity thresholds were measured using microperimetry both before and 7 days after surgery. Linear regression analysis identified factors affecting postoperative sensitivity changes. We also evaluated the correlation between changes in the threshold of retinal light sensitivity at the foveal and paramacular points.</p><p><strong>Results: </strong>Intraocular pressure significantly decreased postoperatively. The mean threshold values of retinal light sensitivity following surgery showed no statistically significant changes compared with preoperative values across all eyes. Specifically, the mean threshold values increased in 4 eyes, decreased in 2, and remained stable in 18. Upon analyzing each examination point, 71.8% eyes exhibited stability, 12.8% showed a decrease of less than -6 dB, and 15.4% demonstrated an improvement of more than +6 dB in threshold values of retinal light sensitivity post-surgery. Changes in retinal light sensitivity at most paramacular points were found to be independent of those at the fovea. Excessive IOP reduction was identified as a significant risk factor for central visual field impairment.</p><p><strong>Conclusions: </strong>Localized changes in retinal light sensitivity thresholds can vary in the early postoperative period following trabeculectomy, highlighting the need to monitor localized retinal function to better understand its impact on visual outcomes.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ab interno removal of malpositioned ex-press glaucoma device combined with bleb needling.","authors":"Daigo Kobayashi, Tadamichi Akagi, Tetsuya Togano, Ryu Iikawa, Takeo Fukuchi","doi":"10.1007/s10384-025-01203-5","DOIUrl":"https://doi.org/10.1007/s10384-025-01203-5","url":null,"abstract":"<p><strong>Purpose: </strong>We present an ab interno removal technique combined with a needling procedure for a malpositioned Ex-PRESS glaucoma shunt.</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>This study examined four cases of malpositioned Ex-PRESS shunts. Needle bleb revision was performed to expand the space under the scleral flap and bleb area. Clinical data, including corneal endothelial cell density (ECD), intraocular pressure (IOP), and anterior segment optical coherence tomography images (AS-OCT), were retrieved from clinical records.</p><p><strong>Results: </strong>All four cases underwent ab interno shunt removal combined with needle bleb revision without any serious complications. In three cases of anterior shunt malposition, a reduction in ECD was apparent before surgery but remained relatively stable after surgery. In one patient with posterior shunt malposition, shunt occlusion was suspected before surgery, but bleb formation and IOP improved after surgery. IOP was 8 mmHg to 21 mmHg (median, 10.5 mmHg) before surgery and 5 mmHg to 17 mmHg (median, 10 mmHg) 12 months after surgery. No additional glaucoma surgery was required within the first 12 months; however, after 12 months, two patients required additional glaucoma surgery.</p><p><strong>Conclusion: </strong>Ab interno Ex-PRESS device removal combined with bleb needling is an important procedure in patients with malpositioned Ex-PRESS devices.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-ophthalmic findings of Visual Snow Syndrome in Korea.","authors":"Ha Eun Park, Hyun Jin Shin, Andrew G Lee","doi":"10.1007/s10384-025-01196-1","DOIUrl":"https://doi.org/10.1007/s10384-025-01196-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the neuro-ophthalmologic characteristics, potential triggers, and treatment responses of visual snow syndrome (VSS) in a Korean population.</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>We retrospectively reviewed the data of patients diagnosed with VSS at a tertiary hospital from March 2021 to February 2024. Data on visual and nonvisual symptoms, self-reported events that caused VSS, and medical and psychiatric comorbidities were chart-reviewed. Neuroimaging findings from MRI and ¹⁸F-FDG PET were evaluated, along with treatment responses to pharmacological interventions and filter glasses.</p><p><strong>Results: </strong>The sample comprised 27 men and 36 women, with a mean age of 27±11 years (mean±SD) and onset age of 22.4±11 years. Common symptoms included floaters, palinopsia, anxiety, and depression. Fourteen participants attributed VSS onset to specific ophthalmic events (e.g. refractive surgery or ophthalmic examinations with bright-light). ¹⁸F-FDG PET scans showed hypermetabolism in the visual cortices (81.8%), with no significant MRI abnormalities. Lamotrigine (18.9%), alprazolam (20%), and filter glasses (32.1%) showed modest efficacy in reducing the intensity of VSS.</p><p><strong>Conclusion: </strong>Korean patients with VSS exhibited clinical features, neuroimaging findings, and treatment responses similar to those reported in Western populations. Ophthalmic procedures, such as refractive surgery and bright-light examinations, may act as potential triggers in susceptible individuals. Although functional imaging, including ¹⁸F-FDG PET, may be useful for evaluating VSS, further studies with healthy controls and quantitative analyses are needed to validate its diagnostic value. Given the modest treatment efficacy, a multidisciplinary approach combining pharmacological intervention, filter glasses, and psychological support is essential to optimize outcomes.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of thyroid eye disease combined with myasthenia gravis.","authors":"Yi Wu, Yanxi Li, Weimin He","doi":"10.1007/s10384-025-01208-0","DOIUrl":"https://doi.org/10.1007/s10384-025-01208-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical features and prognostic factors of patients with thyroid eye disease (TED) combined with myasthenia gravis (MG) at a tertiary comprehensive hospital in China during a 10-year period.</p><p><strong>Study design: </strong>retrospective study.</p><p><strong>Methods: </strong>A case series of patients diagnosed with TED combined with MG was conducted at a tertiary general hospital over 10 years. Medical records of general conditions, clinical presentation, imaging and laboratory tests, treatment modalities, and prognostic outcomes were reviewed.</p><p><strong>Results: </strong>Twenty-three patients with TED combined with MG were found throughout the study period. The mean age was 42.57 ± 14.89 years with 10 men and 13 women. Ocular motility disorders (82.61%), diplopia (73.91%), and ptosis (73.91%) were the primary clinical manifestations, and ocular motility disorders with limited movement in all directions were common (17 eyes) (50.00%). Active (69.57%) and moderate-to-severe (82.61%) TED was common, and hyperthyroidism was the most common complication of thyroid disease (57.17%). Ocular MG was the predominant subtype of MG (86.96%). Chest CT or pathologic examination identified thymic hyperplasia in 4 patients (17.39%) and thymoma in 1 patient (4.35%). A statistically significant association was observed between smoking and an unfavorable prognosis of TED combined with MG (P<0.05).</p><p><strong>Conclusions: </strong>MG should be taken into account in patients with TED who exhibit the following: unilateral or bilateral ptosis, ptosis in one eye and upper eyelid retraction in the other, obvious eye movement disorders without or with mild involvement of the extraocular muscles on imaging, and symptoms of morning and evening fluctuations. Ophthalmologists should refer these patients to the Department of Neurology to avoid misdiagnosis or underdiagnosis. The co-occurrence of TED and MG is rare clinically, mostly affecting young and middle-aged women, with ocular MG and hyperthyroidism as the main clinical subtype, and thymic hyperplasia or thymoma in a small percentage. Smoking is an independent risk factor for poor prognosis of TED combined with MG.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the retinal age gap and systemic diseases in the Japanese population: the Nagahama study.","authors":"Takuro Kamei, Masahiro Miyake, Keina Sado, Kazuya Morino, Yuki Mori, Yasuharu Tabara, Fumihiko Matsuda, Hiroshi Tamura, Akitaka Tsujikawa","doi":"10.1007/s10384-025-01205-3","DOIUrl":"https://doi.org/10.1007/s10384-025-01205-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the retinal age gap, defined as the difference between deep learning-predicted retinal age and chronological age, as a potential biomarker of systemic health in the Japanese population.</p><p><strong>Study design: </strong>Prospective cohort study.</p><p><strong>Methods: </strong>Data from the Nagahama Study, a large-scale Japanese cohort study, were used. Participants were divided into fine-tuning (n=2,261) and analysis (n=6,070) cohorts based on their visit status across the two periods. The fine-tuning cohort only included individuals without a history of systemic or cardiovascular diseases. A deep learning model, originally released in the Japan Ocular Imaging Registry, was fine-tuned using a fine-tuning cohort to predict retinal age from images. This refined model was then applied to the analysis cohort to calculate retinal age gaps. We conducted cross-sectional and longitudinal analyses to examine the association of these gaps with systemic and cardiovascular diseases.</p><p><strong>Results: </strong>The retinal age-prediction model achieved a mean absolute error of 3.00-3.42 years. Cross-sectional analysis revealed significant associations between the retinal age gap and a history of diabetes (β = 1.08, p < 0.001) and hyperlipidemia (β = -0.67, p < 0.001). Longitudinal analysis showed no significant association between the baseline retinal age gap and disease onset. However, onset of hypertension (β = 0.35, p = 0.049) and hyperlipidemia (β = 0.34, p = 0.035) showed marginal associations with an increase in retinal age gap over time.</p><p><strong>Conclusion: </strong>The retinal age gap is a promising biomarker for systemic health, particularly in relation to diabetes, hypertension, and hyperlipidemia.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binocular visual function in middle-aged patients with unilateral cataract: multifocal versus enhanced monofocal intraocular lens.","authors":"Ken Hayashi, Motoaki Yoshida, Shin-Ichi Manabe, Koichi Yoshimura","doi":"10.1007/s10384-025-01190-7","DOIUrl":"https://doi.org/10.1007/s10384-025-01190-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare binocular visual function of middle-aged patients in the process of presbyopia progression with unilateral cataract who received a trifocal intraocular lens (IOL; Alcon PanOptix^®) with those who received an enhanced monofocal (EM) IOL (Johnson & Johnson Eyehance^®).</p><p><strong>Study design: </strong>Nonrandomized comparative study.</p><p><strong>Methods: </strong>This study enrolled patients in their 40s and 50s with unilateral cataract whose fellow eyes were myopic and the operated eyes were implanted with either a trifocal IOL (n=28, targeting emmetropia) or an EM IOL (n=28, targeting myopia), and patients whose fellow eyes were emmetropic and the operated eyes were implanted with a trifocal IOL (n=25, targeting emmetropia) or an EM IOL (n=23; targeting emmetropia). At 3 months postoperatively, binocular uncorrected and corrected all-distance VA and contrast VA were compared between patients receiving the trifocal and EM IOLs.</p><p><strong>Results: </strong>In the myopia category, mean binocular uncorrected VA from ∞ to 1.0 m was significantly better (P<0.001) and at near distance was significantly worse (P<0.001) in the trifocal group than in the EM group. In the emmetropia category, binocular uncorrected VA from ∞ to 2.0 m and binocular contrast VA at most contrasts were significantly better in the EM group than in the trifocal group (P≤0.043).</p><p><strong>Conclusion: </strong>Trifocal IOLs provide significantly better binocular uncorrected far to intermediate VAs and worse near VA than EM IOLs in patients whose fellow eye is myopic, while EM IOLs provide significantly better far VA and contrast sensitivity in patients whose fellow eye is emmetropic.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of postoperative delirium with visual acuity after ophthalmic surgeries under local anesthesia.","authors":"Yusuke Koga, Koji Kitazawa, Gen Shinozaki, Kengo Yoshii, Jun-Wei B Hughes, Yohei Yamashita, Kentaro Kojima, Morio Ueno, Shigeru Kinoshita, Chie Sotozono","doi":"10.1007/s10384-025-01200-8","DOIUrl":"https://doi.org/10.1007/s10384-025-01200-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the incidence rate and risk factors for postoperative delirium (POD) following ophthalmic surgery under local anesthesia.</p><p><strong>Study design: </strong>A retrospective study METHODS: We retrospectively investigated the incidence rate of POD in 4658 patients who underwent vitrectomy or glaucoma surgery between January 2009 to March 2023 and analyzed the risk factors with multivariate logistic regression compared to non-delirium patients. Risk indices included age, sex, operation time, preoperative best-corrected visual acuity (pre-BCVA), comorbidity of dementia, and the use of sedative or hypnotic drugs.</p><p><strong>Results: </strong>POD developed in 19 out of 4658 patients (0.41%). POD was more prevalent in older patients and those with dementia (P < 0.001 and P < 0.001, respectively). However, sex, longer operation time, the use of sedative or hypnotic drugs were not associated with POD. The low pre-BCVA in either operated eye or fellow eye was more likely observed in patients with POD (P = 0.003 and P = 0.001, respectively). The multivariate logistic regression analysis revealed that age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.00-1.12; P = 0.04), dementia (OR, 34.95; 95% CI, 12.32-99.15; P < 0.001), pre-BCVA in the operated eye (OR, 2.00; 95% CI, 1.13-3.53; P = 0.02) and pre-BCVA in the fellow eye (OR, 1.83; 95% CI, 1.16-2.89; P = 0.01) were significantly associated with developing POD.</p><p><strong>Conclusions: </strong>POD developed following ophthalmic surgery under local anesthesia. Identified risk factors included older age, comorbid dementia and low pre-BCVA.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of biosimilar infliximab CT-P13 in the treatment of refractory uveitis associated with Behçet's disease.","authors":"Chiuping Lee, Masaki Takeuchi, Tatsukata Kawagoe, Jutaro Nakamura, Etsuko Shibuya, Mami Ishihara, Norihiro Yamada, Yuki Mizuki, Akira Meguro, Yohei Kirino, Yutaro Soejima, Lisa Hirahara, Yuki Iizuka, Nobuhisa Mizuki","doi":"10.1007/s10384-025-01206-2","DOIUrl":"https://doi.org/10.1007/s10384-025-01206-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the effectiveness and safety of the biosimilar infliximab CT-P13 in treating refractory uveitis associated with Behçet's disease.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>A retrospective analysis of medical records from seven patients was conducted, categorizing them into two groups: those initially treated with CT-P13 (Group 1) and those switched from other tumor necrosis factor inhibitors (Group 2). Data on demographics, treatment duration, ocular inflammatory attacks, visual acuity changes, relapse rates, and adverse events were collected.</p><p><strong>Results: </strong>Seven patients (mean age: 32.0 ± 17.7 years) with refractory uveitis associated with Behçet's disease were included. Four patients in Group 1 received CT-P13 as their first-line biologic therapy, of whom two (50%) achieved remission. All patients exhibited a significant reduction in relapses in the 6 months before and after CT-P13 treatment (Wilcoxon test, p = 0.031). Three patients in Group 2, switched from original infliximab, maintained remission for an average of 11.0 ± 2.0 months. Overall, 71.4% of patients achieved remission. No significant changes in visual acuity were observed in either group. One adverse event occurred, but no adverse drug reactions were reported.</p><p><strong>Conclusion: </strong>The biosimilar infliximab CT-P13 appears to be an effective and cost-efficient option for managing refractory uveitis in Behçet's disease. This finding highlights its potential in managing this challenging condition and warrants further investigation in larger patient cohorts.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Heidelberg Multi-Color Anomaloskop with NEITZ anomaloscope OT-II to diagnose color-vision deficiency.","authors":"Kumiko Mokuno, Hiroki Kaneko, Hirotaka Ito, Hiroshi Takahashi, Tetsushi Yasuma","doi":"10.1007/s10384-025-01198-z","DOIUrl":"https://doi.org/10.1007/s10384-025-01198-z","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the degree of agreement between the results of the Heidelberg Multi-Color Anomaloskop (HMC) and NEITZ anomaloscope OT-II (OT-II).</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Methods: </strong>The study included 53 patients who underwent color-vision testing at Kariya Toyota General Hospital between March 2019 and April 2022. The participants included 2 patients with normal color vision, 10 with protanopia, 3 with protanomaly, 22 with deuteranopia, and 16 with deuteranomaly. Color-vision testing was performed using the Ishihara Test for Colour Deficiency, Standard Pseudoisochromatic Plates Part 1, Farnsworth Dichotomous Test for Color Blindness Panel-15, HMC, and OT-II. An agreement was determined using intraclass correlation coefficients (ICC) and Bland-Altman analysis. The minimum, median, and maximum red-green mixture and yellow monochromatic values of the equal values obtained from HMC and OT-II were examined.</p><p><strong>Results: </strong>The ICCs between the results of HMC and OT-II were 0.979, 0.979, and 0.985, for the minimum, median, and maximum red-green mixture and 0.943, 0.755, and 0.919 for the yellow monochromatic values, respectively (p < 0.0001 in all). In the Bland-Altman analysis, the differences were mostly within the limits of agreement. Fixed errors were observed for the maximum red-green mixture and minimum yellow monochromatic values. Proportional errors were observed for the maximum red-green mixture and yellow monochromatic values.</p><p><strong>Conclusions: </strong>HMC and OT-II showed high agreement for all values in the ICC and Bland-Altman analyses. In the Bland-Altman analysis, systemic errors were observed in the maximum red-green mixture value and the minimum and maximum yellow monochromatic values.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}