Evaluation of corneal and anterior segment parameters in pediatric phenylketonuria.

IF 1.9 3区医学 Q2 OPHTHALMOLOGY

Japanese Journal of Ophthalmology Pub Date : 2025-09-26 DOI:10.1007/s10384-025-01283-3

Sevim Ayça Seyyar, Gizem Gürbostan Soysal, Duhan Hopurcuoğlu

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引用次数: 0

Abstract

Purpose: To compare anterior segment parameters in healthy children of the same age with those in children with phenylketonuria (PKU).

Study design: Retrospective observational study METHODS: Data from 25 eyes of PKU patients (study group) and 60 eyes of age- and gender-matched children (control group) were analyzed. The records reviewed included results from a comprehensive ophthalmic evaluation that each participant had previously undergone. This evaluation included refraction evaluation (spherical equivalent), best corrected visual acuity (BCVA) testing, slit-lamp biomicroscopy, fundus examination, intraocular pressure (IOP) measurement, specular microscopy, and corneal topography measurement.

Result: Forty-five (52.9%) age- and sex-matched participants were girls and 40 (47.1%) were boys. The percentage of hexagonal cells (HEX) was 65.53±8.17 in the study group and 69.75±4.19 in the control group (p=0.021). Flat keratometry (K1) was 41.70±1.54 D in the study group and 43.16±1.52 D in the control group (p=0.002). Steep keratometry (K2) was 42.55±1.83 D in the study group and 43.91±1.73 D in the control group (p=0.013).

Conclusion: This study shows that patients with pediatric PKU have differences in the anterior segment parameters, including keratometric values and HEX, when compared with healthy controls.

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儿童苯丙酮尿症角膜和前段参数的评价。

目的：比较同年龄健康儿童与苯丙酮尿症（PKU）儿童前段参数。研究设计：回顾性观察性研究方法：对25只眼PKU患者（研究组）和60只眼年龄和性别匹配的儿童（对照组）的数据进行分析。回顾的记录包括每位参与者之前进行的全面眼科评估的结果。评估包括屈光评估（球面等效）、最佳矫正视力（BCVA）测试、裂隙灯生物显微镜、眼底检查、眼内压（IOP）测量、镜下显微镜和角膜地形图测量。结果：45名（52.9%）年龄和性别匹配的参与者是女孩，40名（47.1%）是男孩。研究组六边形细胞（HEX）百分比为65.53±8.17，对照组为69.75±4.19 （p=0.021）。研究组扁平角膜测量（K1）为41.70±1.54 D，对照组为43.16±1.52 D （p=0.002）。研究组的陡角度数（K2）为42.55±1.83 D，对照组为43.91±1.73 D （p=0.013）。结论：本研究显示，与健康对照组相比，小儿PKU患者在前节参数（包括角膜测量值和HEX）方面存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Ophthalmology 医学-眼科学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.