Japanese Journal of Ophthalmology最新文献

{"title":"Conjunctival allergic inflammation involving the interleukin-23/T helper type 17 immune axis in an experimental allergic conjunctivitis mouse model.","authors":"Rumi Adachi, Jun Shoji, Noriko Inada, Akiko Tomioka, Satoru Yamagami","doi":"10.1007/s10384-026-01333-4","DOIUrl":"10.1007/s10384-026-01333-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the role of the interleukin-23 (IL-23)/T helper type 17 (Th17) immune axis in conjunctival allergic inflammation using a murine model of experimental allergic conjunctivitis (EAC).</p><p><strong>Study design: </strong>Experimental study.</p><p><strong>Methods: </strong>BALB/c mice were assigned to four groups: control (untreated), allergy (EAC), IL-23 (EAC with IL-23 eyelid injection), and non-sensitized IL-23 (non-sensitized with IL-23 eyelid injection). Conjunctival tissue was analyzed histologically to quantify eosinophil and neutrophil infiltration. Gene expression of mRNA in conjunctival tissue was assessed using a PCR array and quantitative RT-PCR.</p><p><strong>Results: </strong>Eosinophilic and neutrophilic infiltration in the subconjunctival tissue was more pronounced in the IL-23 group than in the allergy and control groups. PCR array and quantitative RT-PCR analyses revealed significantly elevated Ccl17/Tarc mRNA expression in the IL-23 group compared to the allergy group. IL-17A mRNA, undetectable in the allergy group, was expressed in the IL-23 group. Additionally, PCR array comparisons between the IL-23 and non-sensitized IL-23 groups showed a significant increase in Rorc and Il1r1 expression in the IL-23 group. At the same time, Mmp3, Ccl7, and Ccr2 were significantly upregulated in the non-sensitized IL-23 group. RT-PCR analysis also demonstrated higher IL-17A mRNA levels in the non-sensitized IL-23 group than in the IL-23 group.</p><p><strong>Conclusion: </strong>IL-23 induces mixed eosinophilic-neutrophilic inflammation in conjunctival tissue, characterized by enhanced Th2 and weak Th17 responses in a murine model of EAC. These findings suggest a modulatory role of the IL-23/Th17 axis in influencing the severity and phenotype of allergic conjunctival inflammation.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1027-1036"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal evaluation of peripheral photoreceptor atrophy in fundus albipunctatus.","authors":"Takuhiro Hayakawa, Kei Mizobuchi, Takaaki Hayashi, Taro Kominami, Koji M Nishiguchi, Shinji Ueno, Kazuki Kuniyoshi, Mineo Kondo, Takeshi Iwata, Kaoru Fujinami, Kazushige Tsunoda","doi":"10.1007/s10384-026-01337-0","DOIUrl":"10.1007/s10384-026-01337-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the long-term longitudinal changes of the retinal morphology and visual function in patients with fundus albipunctatus (FA).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Seventeen Japanese patients with FA who had pathogenic variants of the RDH5 gene were studied in a multicenter retrospective study.</p><p><strong>Results: </strong>The baseline ages ranged from 3 to 61 years, and the patients were followed longitudinally for 3 to 21 years. The relative size of the flecks/dots decreased throughout the course of the disease; rapidly in the first and second decades of life and slowly thereafter. The flecks/dots in the OCT images were seen as hyperreflective flat deposits on the retinal pigment epithelium in the first decade of life, and as hyperreflective pile-like formations that extended to the ellipsoid zone (EZ) of the photoreceptors after the second decade of life. At later ages, the EZ in the mid-peripheral retina was not present due to photoreceptor atrophy. The Goldmann visual fields had a peripheral constriction in 7 of 11 cases that developed during the course of the disease process.</p><p><strong>Conclusion: </strong>The long-term longitudinal observations of the morphological changes of the retina and visual fields revealed that FA is a slowly progressive retinal dystrophy with atrophy of the peripheral photoreceptors in older patients. These findings will be very important information for the patients when providing genetic counseling.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"852-866"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of sepetaprost in patients with primary open-angle glaucoma or ocular hypertension: results from the randomised, phase 3 ANGEL-J1 study.","authors":"Masaru Inatani, Akiyasu Kanamori, Maya Inai, Toshihiro Ikeda, Raymund Angeles","doi":"10.1007/s10384-026-01350-3","DOIUrl":"10.1007/s10384-026-01350-3","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of sepetaprost, a novel dual FP/EP3 receptor agonist, in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT).</p><p><strong>Study design: </strong>ANGEL-J1 (NCT05495061) was a phase 3, randomised, investigator-masked, active-controlled, parallel-group, non-inferiority study across 49 sites in Japan.</p><p><strong>Methods: </strong>Adults with POAG or OHT were randomised 1:1 to topical sepetaprost 0.002% or latanoprost 0.005%, once daily for 3 months. The primary endpoint was change in mean diurnal intraocular pressure (IOP) from baseline at week 4 (non-inferiority margin, 1.5 mmHg); a key secondary endpoint was mean change in IOP from baseline over 3 months. Safety outcomes included the incidence of adverse drug reactions (ADRs).</p><p><strong>Results: </strong>In total, 325 patients were randomised to sepetaprost (n=162) or latanoprost (n=163). In mixed model for repeated measures analyses, ANGEL-J1 met its primary endpoint; the least-squares mean (± standard error) change in mean diurnal IOP from baseline at week 4 was -5.77±0.16 mmHg in the sepetaprost group, which was non-inferior to -6.10±0.16 mmHg in the latanoprost group (least-squares mean difference, 0.32 mmHg [95% confidence interval, -0.12, 0.77]). Non-inferiority for the key secondary endpoint was also established, with comparable mean reductions in IOP between groups maintained over 3 months. ADRs occurred in 59 patients (36.4%) receiving sepetaprost and 33 (20.2%) receiving latanoprost; the most common ADR was conjunctival hyperaemia (29.6% and 8.6%, respectively; mostly mild in severity).</p><p><strong>Conclusion: </strong>In patients with POAG or OHT, sepetaprost demonstrated IOP-lowering efficacy that was non-inferior to latanoprost, and an acceptable safety profile.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"957-965"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of surgically induced astigmatism following PreserFlo MicroShunt implantation versus trabeculectomy in Japanese patients with glaucoma.","authors":"Yukako Ishiyama, Shiroaki Shirato, Makoto Aihara, Rei Sakata","doi":"10.1007/s10384-026-01355-y","DOIUrl":"10.1007/s10384-026-01355-y","url":null,"abstract":"<p><strong>Purpose: </strong>We compared the magnitude of surgically induced astigmatism (SIA) following PreserFlo MicroShunt (PMS) implantation versus conventional trabeculectomy (Trab), with both procedures being performed with mitomycin C (MMC).</p><p><strong>Study design: </strong>Retrospective cohort study METHODS: We included 113 eyes of 113 patients who underwent standalone PMS surgery and 78 eyes of 78 patients who underwent standalone Trab, all with no previous history of glaucoma surgery. Corneal astigmatism was measured preoperatively and at 3 months postoperatively by use of an automated keratometer. The mean SIA (M-SIA) and centroid SIA (C-SIA) were calculated by use of a dedicated vector analysis tool. Preoperative and postoperative intraocular pressure (IOP) and visual acuity (VA) were compared by use of paired t tests. The Mann-Whitney U test was used to compare the M-SIA between the groups.</p><p><strong>Results: </strong>Postoperatively, the IOP decreased from 20.9 to 11.5 mm Hg in the PMS group and from 20.6 to 9.3 mm Hg in the Trab group (P <0.001 for both). The C-SIA demonstrated an astigmatic shift toward the site of tube insertion in the PMS group and toward the scleral flap location in the Trab group. The M-SIA was significantly lower in the eyes treated with PMS than in those treated with Trab in the superonasal quadrant, but not in the superotemporal site. The VA remained stable in the PMS group, whereas a significant decline was observed in the Trab group.</p><p><strong>Conclusions: </strong>The PMS is an effective surgical option for reducing IOP while minimizing SIA at 3 months postoperatively. By better preserving visual function, the PMS may contribute to improved vision and overall patient satisfaction with the surgical outcomes.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"931-939"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year outcomes of treat-and-extend regimen with intravitreal aflibercept 8 mg for treatment-naïve neovascular age-related macular degeneration.","authors":"Hidetaka Matsumoto, Junki Hoshino, Saki Numaga, Yosuke Asatori, Hideo Akiyama","doi":"10.1007/s10384-026-01356-x","DOIUrl":"10.1007/s10384-026-01356-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate 1-year outcomes of loading phase treatment followed by a treat-and-extend (TAE) regimen with intravitreal aflibercept 8 mg for neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Retrospective, interventional case series.</p><p><strong>Methods: </strong>We retrospectively studied 83 eyes of 80 consecutive patients with treatment-naïve nAMD, assessing best-corrected visual acuity (BCVA), foveal thickness (FT), central choroidal thickness (CCT), total number of injections over 1 year, and intended injection interval at the last visit.</p><p><strong>Results: </strong>Sixty eyes (72.3%) completed the 1-year aflibercept 8mg treatment. Their BCVA improved significantly, with significant reductions in FT and CCT, for up to 1 year. The total number of injections was 6.5±0.7, and the intended injection interval at the last visit was 13.4±3.3 weeks. Of the 23 eyes (27.7%) failing to complete the 1-year treatment, 9 (10.8%) developed non-infectious intraocular inflammation (IOI) associated with retinal vasculitis during the loading phase, leading to treatment discontinuation. Moreover, 7 eyes (8.4%) were switched to intravitreal brolucizumab due to persistent exudation with an 8-week interval of aflibercept 8mg injections in the maintenance phase. The remaining 7 eyes (8.4%) dropped out.</p><p><strong>Conclusions: </strong>Loading phase treatment followed by a TAE regimen with intravitreal aflibercept 8 mg appears to be effective for improving visual acuity and ameliorating exudative changes in eyes with nAMD. However, there might be cases in which exudative changes cannot be adequately controlled with injections of aflibercept 8 mg. Moreover, careful monitoring is required due to the potential development of IOI associated with retinal vasculitis during the loading phase.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"867-875"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing absolute and vitreous-normalized reference apparent diffusion coefficient values of the lacrimal gland in healthy individuals.","authors":"Tahsin Aybal, Fatih Mehmet Tezcan","doi":"10.1007/s10384-026-01352-1","DOIUrl":"10.1007/s10384-026-01352-1","url":null,"abstract":"<p><strong>Purpose: </strong>To establish normative apparent diffusion coefficient (ADC) values of the lacrimal gland in a large cohort of healthy subjects and to compare the results with previously reported data.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>Brain magnetic resonance (MR) images of 260 healthy individuals were retrospectively analyzed. ADC measurements were performed bilaterally using a standardized region of interest (ROI) technique. The values were compared according to age and sex. To ensure normalization and standardization, vitreous ADC measurements were performed using the same ROI used for lacrimal gland measurements. Lacrimal gland ADC values were divided by vitreous ADC values.</p><p><strong>Results: </strong>The lacrimal gland ADCmean value was 1.29 ± 0.14 ×10⁻³ mm²/s. No significant difference was observed in terms of ADC measurements between the right and left glands (p > 0.05). Sex had no statistically significant effect on ADC values (p > 0.05). The mean vitreous ADC value was 3.08 ± 0.20 ×10⁻³ mm²/s. The lacrimal gland/vitreous ADCmean ratio was 0.42 ± 0.05. Correlation analysis revealed weak positive correlations between age and lacrimal gland ADCmean (r = 0.185, p = 0.003) and ADCmax (r = 0.260, p < 0.001).</p><p><strong>Conclusion: </strong>This study presents a large series on normative ADC values of the lacrimal gland in healthy individuals. The results provide reliable reference data that may assist in the differential diagnosis of inflammatory and neoplastic pathologies.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"830-834"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-based differences in work styles and career satisfaction in the retina subspecialty in Japan.","authors":"Maiko Maruyama-Inoue, Annabelle A Okada, Miho Nozaki, Hiroko Terashima, Yoko Miura","doi":"10.1007/s10384-026-01348-x","DOIUrl":"10.1007/s10384-026-01348-x","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate differences in work styles and career satisfaction between women and men physicians in the retina subspecialty in Japan using a questionnaire survey.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>A web-based questionnaire was sent as an e-mail link to all 3,027 current members of the Japanese Retina and Vitreous Society in August 2023 with responses collected anonymously in September 2023. The questionnaire consisted of 4 main categories: baseline characteristics, job satisfaction, life events and career advancement, and suitability as a retina specialist and workplace gender equality.</p><p><strong>Results: </strong>Valid responses were received from 614 members, representing a response rate of 20.3%. One-fifth of men (19.0%) were \"very satisfied\" with their job, much higher than the same for women (7.5%) (P < 0.001). Furthermore, there was a significant difference between men and women who \"strongly agreed\" or \"agreed\" that life events were an impediment to one's career (44.3% vs 74.9%) (P < 0.001). There was also a significant difference between men and women who answered \"strongly agree\" when asked whether they felt they were suited to work in the retina subspecialty (31.0% vs 13.4%) (P < 0.001).</p><p><strong>Conclusions: </strong>Our study identified and quantified marked differences in work style and career satisfaction between women and men. Such differences highlight gender-based challenges in the retina subspecialty that could be improved in order to enhance career satisfaction and career longevity of women retina specialists in Japan.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1017-1026"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collaborative care for retinal artery occlusion by ophthalmologists and vascular neurologists: management of systemic complications.","authors":"Ayane Kamikawa, Kohei Kiyohara, Mariko Shirane, Sakurako Shimokawa, Takahiro Hisai, Yoshiyuki Kobayashi, Muneo Yamaguchi, Shoji Notomi, Keijiro Ishikawa, Takuya Kiyohara, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono, Koh-Hei Sonoda, Kuniyuki Nakamura, Yusuke Murakami","doi":"10.1007/s10384-026-01345-0","DOIUrl":"10.1007/s10384-026-01345-0","url":null,"abstract":"<p><strong>Purpose: </strong>Retinal artery occlusion (RAO) is frequently associated with cerebrovascular and cardiovascular events, and guidelines highlight the need for secondary prevention. Since 2019, our hospital has implemented collaborative care between ophthalmologists and vascular neurologists for acute RAO, and here, we report the clinical outcomes before and after this approach.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Eighty-seven patients (mean age: 72.2 ± 13.4 years; 40 male) diagnosed with central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO), or cilioretinal artery occlusion (CLRAO) at Kyushu University Hospital between March 2013 and May 2024 were retrospectively analyzed, and information on patient backgrounds, ocular and systemic examinations, and treatments was obtained.</p><p><strong>Results: </strong>The disease types were CRAO in 58, BRAO in 24, and CLRAO in 5 patients. Systemic complications before and after collaborative care included hypertension (67% before vs 79% after), diabetes (28% vs 17%), dyslipidemia (41% vs 44%), cerebrovascular diseases (21% vs 10%), carotid artery diseases (18% vs 40%, P = 0.03), and cardiac diseases (3% vs 27%, P = 0.002). After initiation of collaborative care, the causes of RAO were identified as large-artery atherosclerosis (LAA) in 29%, cardioembolism (CE) in 23%, undetermined in 38%, other determined in 8%, and insufficient evaluation in 2% of the patients. Anticoagulants were commonly prescribed for patients with CE, whilst antiplatelet agents were prescribed for those with LAA or embolic stroke of undetermined source (ESUS).</p><p><strong>Conclusion: </strong>Integrated collaborative care facilitates prompt detection of systemic vascular complications and initiation of secondary preventive treatments in patients with RAO.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"843-851"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of objective ocular cyclodeviation according to age, sex, and eye side.","authors":"Shinya Takahashi, Toshiaki Goseki, Shingo Noda, Toru Kawanobe, Yasuhito Ikeda, Eri Ishikawa, Yuichiro Tanaka, Tadahiko Kozawa","doi":"10.1007/s10384-026-01349-w","DOIUrl":"10.1007/s10384-026-01349-w","url":null,"abstract":"<p><strong>Purpose: </strong>We measured objective cyclodeviation in patients aged 10-90 years and evaluated differences between age groups, sexes, and eye sides using the disc-fovea angle (DFA).</p><p><strong>Study design: </strong>Retrospective observational study METHODS: Patients who underwent fundus photography at Kozawa Eye Hospital and Diabetes Center between January 2016 and August 2021 were included. The participants aged 10-90 years were allocated into 10-year age groups. Each age group comprised 400 eyes from 200 participants (100 male and 100 female participants), resulting in a total of 3,600 eyes from 1,800 participants. DFA, defined as the angle between a horizontal line passing through the macula and the line joining the central fossa and papillary center, was analyzed using the Angle Tool in ImageJ software. When the horizontal line passing through the macula was higher than the line joining the central fossa and papillary center, the eye was classified as having excyclotorsion, indicated by a positive sign.</p><p><strong>Results: </strong>DFA increased with age, from 6.37 ± 3.56° in participants in their 10s to 8.46 ± 3.96° in those in their 90s (p < 0.0001). DFA was significantly different between sexes (male vs. female: 7.25 ± 3.60° vs. 7.65 ± 3.71°; p < 0.0001). Additionally, a significant difference was observed between eye sides (right vs. left eye: 7.13 ± 3.69° vs. 7.77 ± 3.60°; p < 0.0001).</p><p><strong>Conclusion: </strong>DFA increases with age, exhibits higher values in female individuals, and shows greater measurements in the left eye.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"788-795"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for postoperative endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal dystrophy using anterior segment optical coherence tomography.","authors":"Motohiro Ueda, Yoshinori Oie, Sayo Maeno, Chifune Kai, Rei Kamuro, Takeshi Soma, Toshiki Shimizu, Ami Igarashi, Yuto Yukari, Takahiko Hayashi, Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Ryo Kawasaki, Kohji Nishida","doi":"10.1007/s10384-026-01360-1","DOIUrl":"10.1007/s10384-026-01360-1","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze anterior segment optical coherence tomography (AS-OCT)-derived risk factors for endothelial keratoplasty (EK) after cataract surgery in patients with Fuchs endothelial corneal dystrophy (FECD).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>We included 73 eyes from 55 consecutive patients with FECD who underwent cataract surgery at three tertiary care institutions between March 2017 and July 2023. We explored the association between preoperative factors (age, sex, incision site, central corneal thickness, anterior chamber depth, components for the anterior and posterior corneal surfaces by Fourier analysis, and signal intensity by AS-OCT) and the requirement for EK within 12 months after cataract surgery. We performed univariate and multivariate regression analyses to calculate the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Of the 73 eyes, 27 (37.0%) required EK. In the univariate analysis, the higher order irregularity component of the 6 mm posterior corneal surface by Fourier analysis yielded the highest AUC of 0.86 (sensitivity: 0.85; specificity: 0.74). In the multivariate analysis, the asymmetry component of the 3 mm anterior corneal surface by Fourier analysis yielded the highest AUC of 0.94, in addition to age, sex, incision site, and anterior chamber depth (sensitivity: 0.93; specificity: 0.85). Thus, we developed a novel logistic regression model incorporating fully quantitative imaging biomarkers from AS-OCT to estimate the probability of requiring EK.</p><p><strong>Conclusion: </strong>The multiple regression model might provide a practical framework for optimizing surgical planning in patients with FECD undergoing cataract surgery, including deciding for either cataract surgery alone or combined EK.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"804-812"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}