Japanese Journal of Ophthalmology最新文献

{"title":"Insights into intraocular pressure spikes following gonioscopy-assisted transluminal trabeculotomy (GATT): timing, predictors and clinical outcomes.","authors":"Gizem Taskin, Nese Alagoz, Ihsan Cakir, Cigdem Altan, Gulsah Gumus Akgun, Tekin Yasar","doi":"10.1007/s10384-025-01273-5","DOIUrl":"10.1007/s10384-025-01273-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the frequency, timing, and characteristics of intraocular pressure (IOP) spikes following standalone Gonioscopy-Assisted Transluminal Trabeculotomy (GATT), and to assess their predictors and management strategies.</p><p><strong>Study design: </strong>A retrospective observational study.</p><p><strong>Methods: </strong>A total of 210 eyes that underwent 360° GATT between September 2021 and January 2024 at our tertiary eye hospital were included. Demographics, best-corrected visual-acuity (BCVA), IOP, antiglaucoma medications, complications and interventions were recorded. IOP spikes were defined as >30 mmHg or >10 mmHg above baseline within two months postoperatively and classified as hyperacute (0-3 days), acute (4-9 days), or subacute (10-60 days). Surgical success was defined as IOP: 5-21 mmHg with ≥20% reduction from baseline. Primary outcomes included spike characteristics, associated factors, and success rates.</p><p><strong>Results: </strong>Seventy-one eyes (33.8%) developed IOP spikes, with a mean IOP of 33.9±6.5 mmHg and duration of 2.0 ± 2.6 days. Hyperacute spikes had more fibrinoid reaction (p=0.026) and higher total success (p=0.049); acute spikes had higher maximal preoperative IOP and longer hyphema duration (p=0.02, p=0.006, respectively); and subacute spikes had prolonged topical corticosteroid use, longer axial length, and prior vitrectomy (p=0.003, p=0.04, p=0.004, respectively). Total surgical success was 91.9%, with higher rates in the non-spike group (99.3% vs. 77.5%, p<0.001). Fibrinoid reaction, prolonged topical corticosteroid use, and prior vitrectomy were associated with postoperative IOP spikes.</p><p><strong>Conclusion: </strong>Postoperative IOP spikes are significantly correlated with surgical failure following GATT. Their timing might reflect differences in underlying mechanisms. Prompt management of complications associated with IOP spikes is essential to reduce failure.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying novel risk factors for ocular lesions in patients with fungemia and determining the efficacy of routine screening.","authors":"Taishi Miyase, Kiyofumi Mochizuki, Hideaki Kawakami, Jun Yonetamari, Masayuki Inuzuka, Shota Sakai, Shinsuke Suemori, Hisashi Baba, Hirokazu Sakaguchi","doi":"10.1007/s10384-025-01269-1","DOIUrl":"10.1007/s10384-025-01269-1","url":null,"abstract":"<p><strong>Purpose: </strong>To identify novel risk factors associated with the presence of fungal ocular lesions in patients with fungemia and to evaluate the validity and efficacy of routine screening.</p><p><strong>Study design: </strong>Retrospective study METHODS: The medical records of 198 patients diagnosed with fungemia by blood culture at 3 medical centers in Japan between March 2017 and April 2022 were analyzed. Ocular lesions were categorized as possible, probable, or proven, according to previously established definitions. The primary outcome measure was prevalence of ocular lesions. Secondary outcomes included the classification of ocular lesions and mortality.</p><p><strong>Results: </strong>Among the 198 patients with fungemia, 115 underwent fundus examination. Ocular lesions were observed in 40 patients (34.8%), with 16 classified as probable and 24 as possible. Among those with positive ocular lesions, 5 (12.5%) complained of ocular symptoms, whereas 21 (52.5%) had impaired consciousness. Impaired consciousness was associated with an increased prevalence of ocular lesions (odds ratio [OR], 2.70). Bedside ophthalmic consultations were associated with the classification of ocular lesions (OR, 0.0485). Positive ocular lesions and echinocandin administration were associated with mortality (ORs, 3.180 and 4.140, respectively).</p><p><strong>Conclusion: </strong>Our study results demonstrate that impaired consciousness is an independent risk factor for ocular lesions. Moreover, the presence of ocular lesions was determined to be an independent factor associated with mortality, highlighting the importance of detecting these lesions in systemic management. Based on these findings, we recommend dilated fundus examination by ophthalmologists in patients with fungemia who do not complain of visual symptoms.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoluminal lacrimal duct recanalization for pediatric secondary acquired lacrimal duct obstruction following epidemic keratoconjunctivitis.","authors":"Tomoko Ohno, Satoshi Goto, Jutaro Nakamura, Kizuku Kumagai, Jun Shindo, Mizuki Asano, Nobuhisa Mizuki, Nozomi Matsumura","doi":"10.1007/s10384-025-01259-3","DOIUrl":"https://doi.org/10.1007/s10384-025-01259-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the efficacy of endoluminal lacrimal duct recanalization (ELDR) with intubation using dacryoendoscopy for secondary acquired lacrimal duct obstruction (SALDO) following epidemic keratoconjunctivitis (EKC) in children.</p><p><strong>Study design: </strong>Prospective observational study.</p><p><strong>Methods: </strong>We included 27 pediatric patients with EKC-derived SALDO between 2013 and 2023. All patients underwent ELDR with intubation for lacrimal pathway obstruction after EKC.</p><p><strong>Results: </strong>We included 14 boys and 13 girls with unilateral obstructions (20 right and 7 left). The mean age at EKC onset and treatment was 23.4 ± 24.1 and 58.9 ± 42.4 months, respectively, and the mean interval from onset to treatment was 35.9 ± 29.0 months. Nineteen cases had a single blockage (common canalicular obstruction [CCO], sac-duct junction [SDJ], punctal obstruction, and canalicular obstruction in 7, 10, 1, and 1 case, respectively); five had two blockages (CCO and SDJ in 4 cases and SDJ and the lower end of the duct in 1 case), and three had diffuse blockages (2 with diffuse proximal nasolacrimal duct obstruction [NLDO] and 1 with CCO and diffuse proximal NLDO). All patients had tube stents, with a mean intubation period of 64.0 ± 26.3 days. Outcomes were classified as good, fair, and poor in 25 patients, 2 patients, and none, respectively.</p><p><strong>Conclusion: </strong>CCO and SDJ were the primary lacrimal pathway obstruction sites following EKC in children. ELDR combined with intubation using dacryoendoscopy demonstrated favorable outcomes, supporting its role as an effective treatment option for secondary EKC-derived SALDO in children.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in higher-order aberrations and refractive error in Japanese school children: the Kyoto Childhood Refractive Error Study (KRES).","authors":"Yo Nakamura, Osamu Hieda, Yoshinori Nakai, Mitsuko Nakata, Chie Sotozono, Shigeru Kinoshita","doi":"10.1007/s10384-025-01272-6","DOIUrl":"https://doi.org/10.1007/s10384-025-01272-6","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate and analyze gender-related differences in myopia prevalence and factors associated with myopia progression in school-aged children.</p><p><strong>Study design: </strong>Observational study.</p><p><strong>Methods: </strong>This study involved 2,298 eyes (boys = 1194 eyes; girls=1104 eyes) of 1149 school children (597 boys; 552 girls) in two elementary/junior high schools in Kyoto Japan, examined from 2013 through 2022. Gender differences in all grades were evaluated in regard to subjective and objective refractive error (RE), axial length (AL), corneal keratometry, higher-order aberrations (HOAs), and a questionnaire regarding environmental factors of myopia progression.</p><p><strong>Results: </strong>In the girls in all grades, corneal keratometry was steeper and AL was shorter (p<0.05), coma-like and total aberration (in 6mm) corneal HOAs, coma-like, spherical-like, and total aberration (in 6mm) ocular HOAs were larger (p<0.05), in addition, only spherical aberration (in 4mm) corneal HOAs were smaller. In all grades, no gender-related differences were found in myopia prevalence (Grade 1: boys = 6.1%; girls = 6.5%, Grade 9: boys = 60.4%; girls = 65.4%) as well as RE. The questionnaire findings revealed that in all grades the girls spent more time reading and less time playing mobile-phone-app games (p<0.001).</p><p><strong>Conclusions: </strong>In Japanese school children, AL was shorter in the girls than in the boys, although, no gender-related differences were observed in myopia prevalence. The steeper cornea in girls might be associated with that discrepancy, and partially with gender differences of HOAs. Gender-specific differences of AL and HOAs should be considered in the analysis of myopia progression in school-aged children.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and prognosis of sagging eye syndrome in Japanese population.","authors":"Kyo Fukaya, Kie Iida, Takumi Aoki, Serina Kuga, Naoko Shioya, Keiko Kunimi, Toshiaki Goseki","doi":"10.1007/s10384-025-01221-3","DOIUrl":"10.1007/s10384-025-01221-3","url":null,"abstract":"<p><strong>Purpose: </strong>Sagging eye syndrome (SES) is the leading cause of acquired diplopia; however, there are no comprehensive reports on its treatment and prognosis in Japan. This study aimed to examine the disease classification of binocular diplopia in patients aged over 40 years old and examine the treatment methods and prognosis of SES.</p><p><strong>Study design: </strong>Retrospective observational case series.</p><p><strong>Methods: </strong>We reviewed the medical records of all new patients aged 40 years or older with binocular diplopia who visited the International University of Health and Welfare, Atami Hospital, between January 2020 and December 2022. Clinical causes of diplopia were analyzed based on age and sex; binocular alignment, treatment types, and post-treatment outcomes were documented for patients with SES, age-related distance esotropia, and cyclovertical strabismus.</p><p><strong>Results: </strong>Among the 199 patients with binocular diplopia, SES was identified as the most common cause, affecting 95 (47.7%) individuals. Women comprised 52.6% of SES cases and 49% of non-SES cases (p=0.67). The mean age of onset was 71.2 ± 10.8 years for binocular diplopia, 76.2 ± 6.5 years for SES, and 66.6 ± 12.0 years for other etiologies (p<0.001). SES treatments included surgery (48.4%, n=46), prism glasses (35.9%, n=34), and observation (15.8%, n=15). Among the 46 patients who underwent surgery and 34 who were prescribed prism glasses, 7 and 2 had residual diplopia, respectively, which resolved after additional treatment.</p><p><strong>Conclusion: </strong>SES is a common cause of binocular diplopia in adults; however, effective treatment can successfully resolve diplopia in most cases.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"673-680"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dacryoendoscopy as a frontier technology for lacrimal drainage disorders.","authors":"Manabu Sugimoto, Yasushi Inoue, Atsushi Shiraishi","doi":"10.1007/s10384-025-01255-7","DOIUrl":"10.1007/s10384-025-01255-7","url":null,"abstract":"<p><p>Dacryocystorhinostomy (DCR) for adult patients with acquired nasolacrimal duct obstruction can be performed via 2 approaches: an external nasal approach from the skin and an internal nasal approach from the nasal cavity. Both techniques have a history of over 100 years and are the gold standard approaches for the treatment of nasolacrimal duct obstructions. Alternatively, researchers have also attempted lacrimal passage reconstruction using various stents to restore the patency of the lacrimal passage, with nunchaku-type silicone tubes showing good surgical results according to several published reports. However, in cases in which the procedure required blind manipulation, the results were largely dependent on the surgeon's skill. Under such circumstances, the dacryoendoscope was introduced at the beginning of this century and is currently widely used. In other fields, especially in gastroenterology, the introduction of gastrointestinal endoscopes that enable observation and treatment of lesions under direct observation has dramatically improved the treatment of gastrointestinal disorders. Considering that the dacryoendoscope has become standardized over the past 20 years since its introduction, this review summarizes the current status of lacrimal passage treatment using the dacryoendoscope.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"661-672"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Retinal displacement using optical coherence tomography angiography and metamorphopsia in eyes undergoing macular hole surgery.","authors":"Shun Tsukahara, Asuka Takeyama, Masahiro Ishida","doi":"10.1007/s10384-025-01247-7","DOIUrl":"10.1007/s10384-025-01247-7","url":null,"abstract":"","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"833-834"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative evaluation of inflammation after phacoemulsification surgery: anterior chamber flare and choroidal vascular index.","authors":"Metehan Simsek, Gulay Yalcınkaya Cakir, Efe Koser, Cigdem Altan, Muhittin Taşkapılı","doi":"10.1007/s10384-025-01220-4","DOIUrl":"10.1007/s10384-025-01220-4","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the relationship between phacoparameters and inflammation parameters (anterior chamber flare (ACF), macular and peripapillary choroidal vascular index (mCVI and pCVI)) changes after cataract surgery.</p><p><strong>Study design: </strong>Prospective study METHODS: This prospective observational study included patients without systemic and ocular diseases who underwent uncomplicated cataract surgery that may have affected intraocular inflammation. Preoperative, postoperative 1st week, 1st, 3rd and 6th months ACF were measured. At the same visits, mCVI and pCVI were calculated. The relationship between phacoparameters and postoperative ACF, mCVI and pCVI values were evaluated by correlation analysis.</p><p><strong>Results: </strong>Fifty eyes of 50 patients were included in the study. Postoperative 1st week ACF was significantly higher than preoperative ACF (p<0.001). ACF decreased significantly from postoperative 1st week to 6th months. Postoperative 1st month and 3rd month mCVI were significantly higher than preoperative mCVI (p<0.001, p=0.04, respectively). It was observed that pCVI reached its peak value in the 1st postoperative week and decreased to base value in the postoperative 6th month. A strong positive linear correlation was found between total cumulative dissipated energy (CDE) and the difference between postoperative 1st week and preoperative ACF (p<0.001, r=0.68).</p><p><strong>Conclusion: </strong>Particularly in the early period after phacoemulsification, ACF, mCVI and pCVI increased. The increase in ACF lost its significance at the third month and the increase in mCVI and pCVI remained significant, which may indicate that the inflammatory effect of cataract surgery lasts longer in the posterior segment. Total CDE can be used to predict postoperative inflammation levels.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"813-822"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and limitations of amniotic membrane transplantation in cases of severe ocular surface disorders: retrospective analysis over a 21-year period.","authors":"Kohei Harada, Hideki Fukuoka, Koji Kitazawa, Yulia Aziza, Tsutomu Inatomi, Tomoyuki Hino, Go Horiguchi, Satoshi Teramukai, Shigeru Kinoshita, Masafumi Uematsu, Takashi Kitaoka, Chie Sotozono","doi":"10.1007/s10384-025-01209-z","DOIUrl":"10.1007/s10384-025-01209-z","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the reoperation rate of amniotic membrane transplantation (AMT) and clarify the risk factors for AMT reoperation in severe ocular surface (OS) disorders (OSD).</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Participants: </strong>We reviewed the medical records of all AMT cases between April 1998 and June 2019 at the Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.</p><p><strong>Methods: </strong>Primary diseases and AMT reoperation rates were examined. In severe OSD cases (Stevens-Johnson syndrome, ocular cicatricial pemphigoid, and chemical/thermal burns), preoperative OS Grading Score (OSGS), surgical procedures combined with AMT, and risk factors for reoperation were investigated and assessed.</p><p><strong>Results: </strong>Over a period of 21 years and 3 months, 750 AMTs were performed on 664 eyes of 594 cases. AMT was repeated on 51 of those 664 eyes (7.7%), and most frequently performed on 25 out of 196 eyes (12.8%) afflicted with severe OSDs. In severe OSDs, OSGS was significantly higher in the reoperation group compared to no-reoperation group (P<0.05), suggesting corneal epithelial defects, conjunctival hyperemia, trichiasis, mucocutaneous junction involvement, and corneal opacity as being risk factors for re-AMT (univariate analysis). In logistic regression analysis, only conjunctival hyperemia was a risk factor, with odds ratios (OR) of 2.65 (95%CI: 1.34-5.22, P=0.005). AMT combined with cultivated or donor corneal epithelial transplantation reduced reoperation risk with an OR of 0.92 and 0.63, respectively.</p><p><strong>Conclusions: </strong>In severe OSD cases, the effect of AMT is limited. Higher OSGSs, especially in conjunctival hyperemia, are associated with a high risk of repeat AMT.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"694-701"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating efficacy of 0.125% atropine using a myopia progression machine learning model.","authors":"Chang Yoon Han, Sa Ra Kim, Dae Hee Kim","doi":"10.1007/s10384-025-01212-4","DOIUrl":"10.1007/s10384-025-01212-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the usefulness of a machine learning (ML) model that can predict the natural course of childhood myopia in evaluation of the inhibitory effects of 0.125% atropine on the progression of childhood myopia.</p><p><strong>Study design: </strong>Retrospective, cohort study.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on children treated daily with 0.125% atropine eye drops. The children were classified into 6-, 12-, 18-, 24-, and 30-month group based on the treatment duration. Spherical equivalents (SE) at the last treatment time point were compared with the pretreatment and ML-predicted SE. The myopia suppression rate due to treatment was calculated based on the first- and ML-predicted SE.</p><p><strong>Results: </strong>A total of 771 eyes (402 boys and 369 girls) from 397 children were included. The participants' mean age was 8.0 ± 1.5 years. The first SE of -2.87 ± 1.67 diopters (D), treatment led to a mean SE of -3.44 ± 1.90 D, showing a significant reduction in myopia progression compared to the ML model's prediction of -4.12 ± 1.75 D. Except for the 6-month group, the last SE was statistically significantly less myopic than the predicted SE, indicating that treatment suppressed progression compared to the natural course. The mean myopia suppression rate was 53.5%, with definite differences between the groups.</p><p><strong>Conclusion: </strong>Treatment with 0.125% atropine may suppress myopia progression in children compared with the ML child myopia prediction model. The application of a machine learning model to predict myopia progression may assist in evaluating the efficacy of 0.125% atropine treatment.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"681-686"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}