Japanese Journal of Ophthalmology最新文献

{"title":"Two-year outcomes of treat-and-extend regimen with intravitreal faricimab for treatment-naïve neovascular age-related macular degeneration.","authors":"Junki Hoshino, Hidetaka Matsumoto, Saki Numaga, Kosuke Nakamura, Hideo Akiyama","doi":"10.1007/s10384-025-01204-4","DOIUrl":"https://doi.org/10.1007/s10384-025-01204-4","url":null,"abstract":"<p><strong>Purpose: </strong>We previously reported 1-year outcomes of a treat-and-extend (TAE) regimen with intravitreal faricimab (IVF) for treatment-naïve neovascular age-related macular degeneration (nAMD). Herein, we evaluated the second-year results of this TAE regimen with IVF in eyes completing the first-year treatment.</p><p><strong>Study design: </strong>Retrospective, interventional case series.</p><p><strong>Methods: </strong>We retrospectively studied 30 eyes with treatment-naïve nAMD that had completed the initial year of treatment, assessing best-corrected visual acuity (BCVA), foveal thickness (FT), central choroidal thickness (CCT), total number of injections over 2 years, and intended injection interval at the last visit.</p><p><strong>Results: </strong>Twenty-five eyes completed the 2-year IVF treatment. There was no significant difference between pre-treatment and 2 years post-treatment BCVA. FT and CCT both showed significant reductions, maintained during the 2-year study period. The total number of injections was 10.1 ± 1.2 over the 2 years. The intended injection interval at the last visit was 13.0 ± 3.4 weeks. Of 5 eyes not completing 2 years of IVF treatment, 4 were switched to other anti-vascular endothelial growth factor (VEGF) agents due to persistent fluids despite IVF at 8-week intervals. In the remaining eye, IVF treatment was discontinued due to suspected faricimab-related intraocular inflammation.</p><p><strong>Conclusions: </strong>The TAE regimen with IVF for treatment-naïve nAMD was effective during a 2-year period for improving exudative changes and maintaining visual acuity. Although IVF was found to be a relatively safe treatment for nAMD, there were cases requiring a switch to other anti-VEGF agents due to inadequate fluid control effect.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors predictive of treatment outcomes in submacular hemorrhage secondary to age-related macular degeneration.","authors":"Yuto Watanabe, Takashi Koto, Aya Takahashi, Masaharu Mizuno, Tomoka Ishida, Kosuke Nakajima, Jun Takeuchi, Tadashi Yokoi, Makiko Nakayama, Annabelle A Okada, Makoto Inoue, Keiko Kataoka","doi":"10.1007/s10384-025-01207-1","DOIUrl":"https://doi.org/10.1007/s10384-025-01207-1","url":null,"abstract":"<p><strong>Purpose: </strong>To identify predictors for visual outcomes of eyes with submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Clinical data from patients diagnosed with SMH secondary to nAMD and treated with pneumatic displacement were collected. SMH thickness was measured by optical coherence tomography (OCT) at baseline and 1 week. Possible factors associated with best-corrected visual acuity (BCVA) gain at 3 months were analyzed.</p><p><strong>Results: </strong>Fifty-six eyes of 56 patients (18 female/38 male; mean age, 77.8 ± 10.1 years) were analyzed; 34 were treatment-naïve and 22 were previously treated with anti-vascular endothelial growth factor agents. Multivariable analysis showed that greater BCVA gain more than 0.3 logMAR at 3 months post-treatment was associated with being treatment-naïve (odds ratio [OR], 34.30; 95% confidence interval [CI], 1.38-851.91; P = 0.031), thinner SMH thickness at 1 week after pneumatic displacement (OR, 0.38 per 50-unit increase; CI, 0.18-0.80; P = 0.011), and worse baseline BCVA (OR, 2.58 per 0.1-unit increase; CI, 1.31-5.07; P = 0.006), but not associated with age (OR, 0.50; 95% CI, 0.24-1.06), the time from onset to pneumatic displacement (OR, 1.04; 95%CI, 0.87-1.23), SMH thickness at baseline (OR, 0.92; 95%CI, 0.63-1.36), and the presence of subfoveal hemorrhagic PED (OR, 0.72; 95%CI, 0.08-6.84).</p><p><strong>Conclusion: </strong>This study identifies novel factors predictive of visual outcomes for pneumatic displacement for SMH due to nAMD. The presence of residual SMH at 1 week following unsuccessful pneumatic displacement may warrant further intervention.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ab interno removal of malpositioned ex-press glaucoma device combined with bleb needling.","authors":"Daigo Kobayashi, Tadamichi Akagi, Tetsuya Togano, Ryu Iikawa, Takeo Fukuchi","doi":"10.1007/s10384-025-01203-5","DOIUrl":"https://doi.org/10.1007/s10384-025-01203-5","url":null,"abstract":"<p><strong>Purpose: </strong>We present an ab interno removal technique combined with a needling procedure for a malpositioned Ex-PRESS glaucoma shunt.</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>This study examined four cases of malpositioned Ex-PRESS shunts. Needle bleb revision was performed to expand the space under the scleral flap and bleb area. Clinical data, including corneal endothelial cell density (ECD), intraocular pressure (IOP), and anterior segment optical coherence tomography images (AS-OCT), were retrieved from clinical records.</p><p><strong>Results: </strong>All four cases underwent ab interno shunt removal combined with needle bleb revision without any serious complications. In three cases of anterior shunt malposition, a reduction in ECD was apparent before surgery but remained relatively stable after surgery. In one patient with posterior shunt malposition, shunt occlusion was suspected before surgery, but bleb formation and IOP improved after surgery. IOP was 8 mmHg to 21 mmHg (median, 10.5 mmHg) before surgery and 5 mmHg to 17 mmHg (median, 10 mmHg) 12 months after surgery. No additional glaucoma surgery was required within the first 12 months; however, after 12 months, two patients required additional glaucoma surgery.</p><p><strong>Conclusion: </strong>Ab interno Ex-PRESS device removal combined with bleb needling is an important procedure in patients with malpositioned Ex-PRESS devices.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-ophthalmic findings of Visual Snow Syndrome in Korea.","authors":"Ha Eun Park, Hyun Jin Shin, Andrew G Lee","doi":"10.1007/s10384-025-01196-1","DOIUrl":"https://doi.org/10.1007/s10384-025-01196-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the neuro-ophthalmologic characteristics, potential triggers, and treatment responses of visual snow syndrome (VSS) in a Korean population.</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>We retrospectively reviewed the data of patients diagnosed with VSS at a tertiary hospital from March 2021 to February 2024. Data on visual and nonvisual symptoms, self-reported events that caused VSS, and medical and psychiatric comorbidities were chart-reviewed. Neuroimaging findings from MRI and ¹⁸F-FDG PET were evaluated, along with treatment responses to pharmacological interventions and filter glasses.</p><p><strong>Results: </strong>The sample comprised 27 men and 36 women, with a mean age of 27±11 years (mean±SD) and onset age of 22.4±11 years. Common symptoms included floaters, palinopsia, anxiety, and depression. Fourteen participants attributed VSS onset to specific ophthalmic events (e.g. refractive surgery or ophthalmic examinations with bright-light). ¹⁸F-FDG PET scans showed hypermetabolism in the visual cortices (81.8%), with no significant MRI abnormalities. Lamotrigine (18.9%), alprazolam (20%), and filter glasses (32.1%) showed modest efficacy in reducing the intensity of VSS.</p><p><strong>Conclusion: </strong>Korean patients with VSS exhibited clinical features, neuroimaging findings, and treatment responses similar to those reported in Western populations. Ophthalmic procedures, such as refractive surgery and bright-light examinations, may act as potential triggers in susceptible individuals. Although functional imaging, including ¹⁸F-FDG PET, may be useful for evaluating VSS, further studies with healthy controls and quantitative analyses are needed to validate its diagnostic value. Given the modest treatment efficacy, a multidisciplinary approach combining pharmacological intervention, filter glasses, and psychological support is essential to optimize outcomes.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of thyroid eye disease combined with myasthenia gravis.","authors":"Yi Wu, Yanxi Li, Weimin He","doi":"10.1007/s10384-025-01208-0","DOIUrl":"https://doi.org/10.1007/s10384-025-01208-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical features and prognostic factors of patients with thyroid eye disease (TED) combined with myasthenia gravis (MG) at a tertiary comprehensive hospital in China during a 10-year period.</p><p><strong>Study design: </strong>retrospective study.</p><p><strong>Methods: </strong>A case series of patients diagnosed with TED combined with MG was conducted at a tertiary general hospital over 10 years. Medical records of general conditions, clinical presentation, imaging and laboratory tests, treatment modalities, and prognostic outcomes were reviewed.</p><p><strong>Results: </strong>Twenty-three patients with TED combined with MG were found throughout the study period. The mean age was 42.57 ± 14.89 years with 10 men and 13 women. Ocular motility disorders (82.61%), diplopia (73.91%), and ptosis (73.91%) were the primary clinical manifestations, and ocular motility disorders with limited movement in all directions were common (17 eyes) (50.00%). Active (69.57%) and moderate-to-severe (82.61%) TED was common, and hyperthyroidism was the most common complication of thyroid disease (57.17%). Ocular MG was the predominant subtype of MG (86.96%). Chest CT or pathologic examination identified thymic hyperplasia in 4 patients (17.39%) and thymoma in 1 patient (4.35%). A statistically significant association was observed between smoking and an unfavorable prognosis of TED combined with MG (P<0.05).</p><p><strong>Conclusions: </strong>MG should be taken into account in patients with TED who exhibit the following: unilateral or bilateral ptosis, ptosis in one eye and upper eyelid retraction in the other, obvious eye movement disorders without or with mild involvement of the extraocular muscles on imaging, and symptoms of morning and evening fluctuations. Ophthalmologists should refer these patients to the Department of Neurology to avoid misdiagnosis or underdiagnosis. The co-occurrence of TED and MG is rare clinically, mostly affecting young and middle-aged women, with ocular MG and hyperthyroidism as the main clinical subtype, and thymic hyperplasia or thymoma in a small percentage. Smoking is an independent risk factor for poor prognosis of TED combined with MG.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world practice patterns for dry eye diagnosis: a multicenter observational study in Taiwan.","authors":"Shu-Wen Chang, Shiuh-Liang Hsu, Chih-Chien Hsu","doi":"10.1007/s10384-025-01175-6","DOIUrl":"10.1007/s10384-025-01175-6","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the concordance between Asia Dry Eye Society (ADES) diagnostic criteria and real-world hospital-based practice, and to analyze the clinical characteristics of patients with dry eye disease (DED), in Taiwan.</p><p><strong>Study design: </strong>Noninterventional, cross-sectional, retrospective clinical study.</p><p><strong>Methods: </strong>Data were analyzed for adults with newly diagnosed DED from three tertiary hospitals. The primary endpoint was the proportion of patients diagnosed with DED who fulfilled ADES criteria for DED. Other outcomes were DED classification and severity, tear breakup time (TBUT), Schirmer's test, corneal fluorescein staining (CFS) severity, 12-item Ocular Surface Disease Index (OSDI) questionnaire scores, and presence of meibomian gland dysfunction (MGD).</p><p><strong>Results: </strong>A total of 213 patients, mean (SD) age 54.3 (15.0) years, 79.8% female, were evaluated. Mean TBUT of 3.0 (2.6) sec and mean OSDI score of 36.5 (21.0) indicated severe DED at diagnosis. Most patients (87.3%) had a TBUT ≤5 sec, fulfilling ADES diagnostic criteria. Short TBUT (≤5 sec) and OSDI ≥13 had high sensitivity for diagnosing DED (87.3% and 90.1%, respectively), whereas an abnormal Schirmer's test (69.5%) and abnormal CFS (42.3%) were less sensitive. MGD was diagnosed in 56.3% of patients. Dry eye-related characteristics in the non-short TBUT (>5 sec) group diverged for objective but not subjective clinical tests. Most common first treatments were artificial tears (95.8%) and corticosteroids (85.0%).</p><p><strong>Conclusions: </strong>DED diagnosis in routine hospital practice in Taiwan is highly concordant (87.3%) with ADES diagnostic criteria. TBUT appears to be an effective diagnostic tool for identifying dry eye in patients across symptom severity, etiology and age.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"343-350"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HTRA1 and complement activation in neovascular age-related macular degeneration.","authors":"Keiichiro Tanaka, Tomoko Omori, Yasuharu Oguchi, Kanako Itagaki, Yutaka Kato, Junichiro Honjo, Koki Norikawa, Yukinori Sugano, Ryo Mukai, Yumi Ishida, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu","doi":"10.1007/s10384-024-01153-4","DOIUrl":"10.1007/s10384-024-01153-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between high temperature requirement A (HTRA1) and the local complement system, we measured HTRA1 and complement activation products in the aqueous humor of patients with neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Surveys (cross-sectional studies).</p><p><strong>Methods: </strong>One hundred twenty-one eyes of 121 patients with nAMD and 55 control eyes were enrolled. HTRA1, complement activation products (C3a and C4a), and proinflammatory cytokines (vascular endothelial growth factor [VEGF] and monocyte chemoattractant protein-1) were measured. Genotyping of ARMS2 A69S, in linkage disequilibrium with the HTRA1 gene, was performed in all patients and controls.</p><p><strong>Results: </strong>The respective GG, GT, and TT genotypes for ARMS2 A69S were distributed as follows: 23 (19.0%), 54 (44.6%), and 44 (36.4%) in nAMD patients, and 26 (47.3%), 22 (40.0%), and 7 (12.7%) in controls, (p < 0.001). HTRA1 concentrations in the aqueous humor were higher in nAMD (994 pg/ml; interquartile range, 743-1450) than controls (794 pg/ml; 490-1325). The difference in the HTRA1 concentrations in the aqueous humor between each genotype of ARMS2 A69S was not significant (GG genotype: 857 pg/ml; 508-1115, GT genotype: 957 pg/ml; 758-1474, TT genotype: 1,141 pg/ml; 757-1663, p = 0.1417). VEGF and C3a concentrations in the eyes with the risk allele (T allele) were significantly higher than those with the non-risk allele (p = 0.0400 and p = 0.0197, respectively). HTRA1 concentration was correlated with only the VEGF concentration (ρ = 0.3651, p < 0.0001).</p><p><strong>Conclusion: </strong>Concentrations of HTRA1 in the aqueous humor were not increased in patients with the ARMS2 risk allele and did not correlate with C3a and C4a concentrations. HTRA1 concentrations in aqueous humor do not reflect local complement activation in nAMD.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"453-459"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the double-dose medial rectus muscle recession technique for sagging eye syndrome with esotropia of 10-prism diopters or less at distance.","authors":"Kie Iida, Toshiaki Goseki, Kyo Fukaya, Takumi Aoki, Serina Kuga, Chiemi Ariga, Hiromi Onouchi, Tadashi Nakano","doi":"10.1007/s10384-025-01195-2","DOIUrl":"10.1007/s10384-025-01195-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the surgical outcomes for small-angle sagging eye syndrome (SES) with a distance horizontal deviation of 10 Δ or less.</p><p><strong>Study design: </strong>Retrospective observational case series METHODS: Six SES patients (mean age 77.2 ± 5.4 years, 4 men and 2 women) with distance esotropia of 10 Δ or less who underwent medial rectus recession at a single center in Shizuoka, Japan, from January 2020 to December 2023 were studied. Patients with high myopia (axial length ≥ 27 mm, refraction ≤-6 D) were excluded. Preoperative and postoperative alternate prism cover tests, Stereo Fly test (SFT) results, and presence of diplopia were assessed.</p><p><strong>Results: </strong>The patients underwent unilateral (n = 5) and bilateral (n = 1) medial rectus recession (6.4 ± 0.65 mm and 4.5 mm respectively), with 1 patient undergoing vertical muscle surgery. Preoperative/postoperative deviations (Δ) were distance horizontal +7.3 ± 2.4/-1.5 ± 2.5 (P = 0.035), distance vertical 2.2 ± 2.0/1.0 ± 1.3 (P = 0.42), near horizontal - 0.3 ± 3.2/-8.3 ± 6.4 (P = 0.058), and near vertical 2.0 ± 1.7/1.3 ± 1.8 (P = 0.59). The SFT (log) value was 1.99 ± 0.31/1.73 ± 0.21 (P = 0.056). Three patients experienced transient postoperative diplopia, which resolved over time. The diplopia improved in patients with concurrent vertical muscle surgery or a preoperative vertical deviation of 2 Δ or less (4 patients, 66.7%). However, those with a preoperative vertical deviation of 3 Δ or more (2 patients, 33.3%) required postoperative prism glasses.</p><p><strong>Conclusion: </strong>Medial rectus recession in small-angle SES with a distance horizontal deviation of 10 Δ or less significantly improved distance horizontal deviation without inducing exotropia at near, with a trend towards improved stereopsis. Patients with a preoperative vertical deviation of 3 Δ or more had persistent postoperative vertical diplopia.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"327-334"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remarkable visual improvement in Leber hereditary optic neuropathy.","authors":"Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1007/s10384-025-01185-4","DOIUrl":"10.1007/s10384-025-01185-4","url":null,"abstract":"<p><strong>Purpose: </strong>Leber hereditary optic neuropathy (LHON) typically has a poor visual outcome. In this study, we examined 8 cases of LHON that demonstrated remarkable visual improvement.</p><p><strong>Study design: </strong>Retrospective observational study, clinical case series METHODS: We analyzed the clinical histories and outcomes of 8 patients (16 eyes) whose best corrected visual acuity (BCVA) improved to 0.7 or higher in at least 1 eye.</p><p><strong>Results: </strong>The median age of onset of the 7 male patients and 1 female patient was 17 years (range 8-58). Genetic testing revealed m.11778G>A mutations in 6 and m.14484T>C mutations in 2 of the patients. Of the 16 eyes, 15 improved to a BCVA of 0.7 or higher, whilst 1 eye achieved a final BCVA of 0.5. The lowest BCVA was below 0.1 in 12/16 eyes. BCVA improved to 0.1 or better within 1 year in 6/12 eyes and to 0.7 or better within 2 years in 12/15 eyes. In 10 eyes monitored by use of Humphrey Field Analysis (HFA; Fastpac, 30-2 program), the mean deviation improved from - 13.2 dB (- 23.6 to - 4.54) at its lowest to - 5.0 dB (- 15.6 to - 0.9) at the final measurement. Final HFA showed residual defects in the temporal region in 7/16 eyes. In the chronic phase, 10/12 eyes displayed either normal optic disc findings or partial temporal pallor.</p><p><strong>Conclusion: </strong>In LHON cases with remarkable visual improvement, the recovery began earlier, and the visual field defects were relatively mild and tended to persist in the temporal region after improvement. Understanding these cases of notable improvement may inform future treatment strategies.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"417-424"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors of late-onset intraocular pressure elevation after vitrectomy with silicone oil tamponade.","authors":"Dong Woo Kim, Se Joon Woo, Kwangsic Joo, Min Seok Kim","doi":"10.1007/s10384-025-01184-5","DOIUrl":"10.1007/s10384-025-01184-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the incidence and risk factors of late-onset intraocular pressure (IOP) elevation in patients who underwent pars plana vitrectomy with silicone oil (SO) injection for the management of various vitreoretinal pathologies.</p><p><strong>Study design: </strong>A retrospective observational study.</p><p><strong>Methods: </strong>A single-center study involving 135 eyes of 129 patients who underwent vitrectomy with SO injections between January 2018 and May 2023 and maintained SO tamponade for ≥1 month. Eyes with prior glaucoma surgery; a history of SO injection; SO removal or exchange within a month; a follow-up period of <1 month; or those who showed IOP elevation on postoperative day 1 were excluded from the analysis. Late-onset IOP elevation was defined as IOP ≥ 21 mm Hg after postoperative day 7.</p><p><strong>Results: </strong>Late-onset IOP elevation developed in 22.2% (30/135 eyes) and the mean onset was 38.0±53.4 days (7-251 days) after surgery. In the multivariate logistic regression analysis, late-onset IOP elevation was associated with pre-existing glaucoma (odds ratio [OR], 7.16; P=0.041), longer axial length (OR, 1.40, P=0.037), and higher preoperative IOP (OR, 1.12; P=0.037). Among the patients with late-onset IOP elevation, 50% (15/30) required oral acetazolamide despite the administration of IOP-lowering eye drops. Among them, surgical intervention was required in 8 cases (53.3%).</p><p><strong>Conclusion: </strong>Late-onset IOP elevation is a common complication associated with SO tamponade. Risk factors for late-onset IOP elevation are pre-existing glaucoma, longer axial length, and preoperative higher IOP. Since a substantial proportion of eyes require surgical intervention, proactive measures should be considered for effective IOP control.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"410-416"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}