Japanese Journal of Ophthalmology最新文献_第4页

Optic nerve head abnormalities in primary open-angle glaucoma and their associations with axial length. 原发性开角型青光眼视神经头异常及其与眼轴长度的关系。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-05-08 DOI: 10.1007/s10384-026-01371-y

Hitomi Saito, Weiwei Wang, Kaho Akiyama, Shuichiro Aoki, Shiroaki Shirato, Rei Sakata, Makoto Aihara, Megumi Honjo

{"title":"Optic nerve head abnormalities in primary open-angle glaucoma and their associations with axial length.","authors":"Hitomi Saito, Weiwei Wang, Kaho Akiyama, Shuichiro Aoki, Shiroaki Shirato, Rei Sakata, Makoto Aihara, Megumi Honjo","doi":"10.1007/s10384-026-01371-y","DOIUrl":"10.1007/s10384-026-01371-y","url":null,"abstract":"Purpose: To determine the frequency of peripapillary retinoschisis (PRS), lamina cribrosa defect (LCD), peripapillary intrachoroidal cavitation (PICC), and prelaminar schisis (PLS) in primary open-angle glaucoma (POAG) eyes and investigate their association with axial length (AXL).Study design: Retrospective cross-sectional METHODS: Optical coherence tomography scans of 263 POAG eyes were reviewed for PRS, LCD, PICC, and PLS. The frequency of each optic nerve head (ONH) abnormality was compared between eyes with and without high myopia (HM), defined as AXL > 26 mm. Associations with AXL were assessed using univariable and multivariable logistic regression, adjusting for gender, age, intraocular pressure, visual field mean deviation, circumpapillary retinal nerve fiber layer thickness and Bruch's membrane opening (BMO) area.Results: PRS, LCD, PICC, and PLS were observed in 11.8%, 31.6%, 18.3%, and 55.1% of all POAG eyes, respectively. 77.2% exhibited at least one abnormality, and 31.2% had multiple abnormalities. PRS, LCD, and PICC were more frequent in HM eyes (p = 0.001, 0.016 and <0.001, respectively) and associated with longer AXL in univariable analysis (p < 0.001). Multivariable analysis showed that PRS significantly associated with longer AXL (p < 0.001) and that LCD and PICC significantly associated with larger BMO area (p = 0.009, < 0.001). PLS was more frequent in eyes without HM (p = 0.026) and significantly associated with shorter AXL (p = 0.005).Conclusion: ONH abnormality was common in myopic POAG eyes with substantial overlaps. PRS, LCD and PICC were associated with longer AXL and myopic ONH structural change while PLS was associated with shorter AXL. These findings will be a foundation for further studies exploring their functional relevance.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1229-1240"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic factors associated with response to as-needed brolucizumab treatment for exudative age-related macular degeneration. 遗传因素与对渗出性年龄相关性黄斑变性按需brolucizumab治疗的反应相关

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-05-19 DOI: 10.1007/s10384-026-01369-6

Seigo Yoneyama, Yoichi Sakurada, Yoshiko Fukuda, Taiyo Shijo, Yumi Kotoda, Wataru Kikushima, Fumihiko Mabuchi, Kenji Kashiwagi

{"title":"Genetic factors associated with response to as-needed brolucizumab treatment for exudative age-related macular degeneration.","authors":"Seigo Yoneyama, Yoichi Sakurada, Yoshiko Fukuda, Taiyo Shijo, Yumi Kotoda, Wataru Kikushima, Fumihiko Mabuchi, Kenji Kashiwagi","doi":"10.1007/s10384-026-01369-6","DOIUrl":"10.1007/s10384-026-01369-6","url":null,"abstract":"Purpose: To investigate the association between genetic variants susceptible to exudative age-related macular degeneration (AMD) and the treatment response to as-needed intravitreal brolucizumab (IVBr) therapy.Study design: Interventional study METHODS: This retrospective study included 103 treatment-naïve eyes with exudative AMD. All eyes received three monthly IVBr injections (6.0 mg/0.05 mL) followed by a pro re nata regimen for 12 months. Seven major AMD-associated single nucleotide polymorphisms-ARMS2 A69S (rs10490924), CFH I62V (rs800292), CFH rs1329428, C2-CFB-SKIV2L rs429608, C3 rs2241394, CETP rs3764261, and ADAMTS9 rs6795735-were genotyped using TaqMan assays. The requirement for retreatment, the number of additional injections, and visual outcomes were compared across genotypes.Results: Of the 103 patients, 68 (66.0%) required additional injections. The T allele of ARMS2 A69S was significantly more frequent in the retreatment group than in the retreatment-free group (65.0% vs. 42.9%, p = 1.9 × 10⁻3) and remained independently associated with retreatment after adjustment for age, sex, and baseline visual acuity (p = 3.0 × 10⁻3). Eyes with the TT genotype required significantly more additional injections than those with the TG or GG genotypes (2.4 ± 1.7 vs. 1.3 ± 1.6 and 1.3 ± 1.5, respectively; p = 5.0 × 10⁻3). Kaplan-Meier analysis demonstrated a significant difference in retreatment-free survival among ARMS2 genotypes (p = 4.1 × 10⁻4). Visual outcomes did not differ across any genotypes.Conclusions: ARMS2 A69S may serve as a predictor of recurrence and number of additional injections in as-needed brolucizumab therapy for exudative AMD.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1115-1121"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal versus superior clear corneal incision for eyes with oblique astigmatism: a randomized comparative study. 斜向散光眼的颞部与上部透明角膜切口：一项随机比较研究。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-06-13 DOI: 10.1007/s10384-026-01370-z

Ken Hayashi, Koichi Uno, Shunsuke Hayashi, Akira Hirata

{"title":"Temporal versus superior clear corneal incision for eyes with oblique astigmatism: a randomized comparative study.","authors":"Ken Hayashi, Koichi Uno, Shunsuke Hayashi, Akira Hirata","doi":"10.1007/s10384-026-01370-z","DOIUrl":"10.1007/s10384-026-01370-z","url":null,"abstract":"Purpose: To compare the amount of total cornea astigmatism and corneal astigmatic change between eyes with near against-the-rule (ATR) and near with-the-rule (WTR) oblique astigmatism that underwent a temporal (TCI) or superior clear corneal incisions (SCI).Study design: Randomized comparative study.Methods: Two-hundred forty eyes with near ATR (46°-59° and 121°-135°; n=120) or near WTR (31°-45° and 136°-149°; n=120) oblique corneal astigmatism of ≥ 0.5 diopters were randomly assigned to undergo a 2.4-mm TCI or SCI. The vertical/horizontal (Rx) and oblique astigmatism components (Ry) were evaluated preoperatively and at 2 months postoperatively. Bivariate analysis was performed to compare between the two time points and the TCI and SCI groups.Results: All 240 eyes were included in the analysis. In eyes with near ATR or near WTR oblique astigmatism, the mean Rx and Ry did not change significantly in the TCI group but were significantly increased from preoperatively to 2 months postoperatively in the SCI group (P≤0.002). The mean Rx and Ry did not differ significantly between the TCI and SCI groups preoperatively, but these values were significantly lower in the TCI group than in the SCI group at 2 months postoperatively (P<0.001).Conclusions: TCI did not significantly change the corneal astigmatism, while SCI increased the astigmatism from preoperatively to 2 months postoperatively in eyes with near ATR or WTR oblique astigmatism. Residual corneal astigmatism at 2 months postoperatively was significantly lower after TCI than after SCI, suggesting that TCI is a more favorable surgical approach for eyes with oblique astigmatism.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1079-1088"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the choroid: investigating scleral and iris thickness in the pachychoroid disease spectrum. 脉络膜外：厚脉络膜疾病谱系中巩膜和虹膜厚度的调查。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-06-04 DOI: 10.1007/s10384-026-01378-5

Elif Akbas Ulman, Cumali Degirmenci, Serhad Nalcaci, Filiz Afrashi, Cezmi Akkin

{"title":"Beyond the choroid: investigating scleral and iris thickness in the pachychoroid disease spectrum.","authors":"Elif Akbas Ulman, Cumali Degirmenci, Serhad Nalcaci, Filiz Afrashi, Cezmi Akkin","doi":"10.1007/s10384-026-01378-5","DOIUrl":"10.1007/s10384-026-01378-5","url":null,"abstract":"Purpose: To compare scleral, iris, and choroidal thickness in central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV) within the pachychoroid disease spectrum, relative to healthy controls.Study design: Retrospective, case-control METHODS: Subfoveal choroidal thickness was evaluated using enhanced depth imaging (EDI) optical coherence tomography (OCT). Scleral thickness was measured 6 mm posterior to the scleral spur in four quadrants, while iris thickness was assessed at IT2000 (2000 µm from the scleral spur) in the nasal and temporal quadrants using anterior segment OCT (AS-OCT).Results: A total of 160 individuals participated, including 40 PCV patients, 40 CSC patients, and their respective control groups. Choroidal thickness was significantly greater in the PCV and CSC groups compared to controls (p =.001). Scleral thickness values were higher in both groups; in the CSC group, differences were significant in the superior (p =.007), nasal (p =.003), and temporal (p =.006) quadrants, whereas in the PCV group, although values were higher across all quadrants, these differences did not reach statistical significance (p =.020-.047). Iris thickness was significantly higher in the nasal and temporal quadrants (nasal: p<.001, p=.014, temporal: p=.015, p=.009). In the controls, choroidal and iris thickness decreased with age and were positively correlated, whereas these relationships were not observed in the case groups.Conclusion: Choroidal, scleral, and iris thicknesses are increased in CSC and PCV patients compared to healthy controls. In the spectrum of pachychoroid disease, thick choroid is a known feature, however thick sclera and iris may also play an important role in the pathogenesis.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1130-1136"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and clinical characteristics of Terson syndrome among survivors of aneurysmal subarachnoid hemorrhage: a nationwide study in Japan. 动脉瘤性蛛网膜下腔出血幸存者中Terson综合征的患病率和临床特征：日本的一项全国性研究

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-07-03 DOI: 10.1007/s10384-026-01375-8

Takahiro Tanaka, Yoshihisa Miyamoto, Shotaro Aso, Yuichiro Matsuo, Kiyohide Fushimi, Hideo Yasunaga

{"title":"Prevalence and clinical characteristics of Terson syndrome among survivors of aneurysmal subarachnoid hemorrhage: a nationwide study in Japan.","authors":"Takahiro Tanaka, Yoshihisa Miyamoto, Shotaro Aso, Yuichiro Matsuo, Kiyohide Fushimi, Hideo Yasunaga","doi":"10.1007/s10384-026-01375-8","DOIUrl":"10.1007/s10384-026-01375-8","url":null,"abstract":"Purpose: To investigate the characteristics of Terson syndrome (TS) among survivors of aneurysmal subarachnoid hemorrhage (aSAH).Study design: Retrospective study METHODS: Using the Japanese Diagnosis Procedure Combination database, we identified patients diagnosed with aSAH at admission between July 1, 2010 and March 31, 2023 in Japan. The prevalence of TS in aSAH survivors was examined, along with comparisons of patient backgrounds between survivors with TS and those without TS. We compared the characteristics and outcomes in patients with TS who underwent vitrectomy with those in patients who did not, and analyzed the laterality of the surgery.Results: Among 143,058 patients with aSAH, 104,576 (73.1%) survived. TS was diagnosed in 860 (0.8%) survivors. The patients with TS were younger (mean [standard deviation, SD] age: 53.3 [11.4] vs 64.0 [14.6] years) than those without TS. Among the patients with TS, 243 (28.3%) patients underwent vitrectomy during hospitalization, with a median interval of 38 days from admission to surgery. Of the patients with TS who underwent vitrectomy, 160 (66.4%) and 81 (33.6%) patients underwent unilateral and bilateral vitrectomy, respectively.Conclusion: In this retrospective study, the prevalence of TS among aSAH survivors was less than 1%. Vitrectomy was performed in approximately one-third of the patients with TS, with one-third of these patients undergoing bilateral surgery during hospitalization.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1278-1286"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of smoking with thyroid eye disease and related diplopia in a Japanese population: a retrospective study. 日本人群中吸烟与甲状腺眼病及相关复视的关系：一项回顾性研究

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.1007/s10384-026-01380-x

Ai Kozaki, Rishu Inoue, Natsuko Watanabe, Nobuyuki Sato, Shunsuke Kawaguchi, Koichi Nishiyama, Koichi Ito, Toshu Inoue

{"title":"Association of smoking with thyroid eye disease and related diplopia in a Japanese population: a retrospective study.","authors":"Ai Kozaki, Rishu Inoue, Natsuko Watanabe, Nobuyuki Sato, Shunsuke Kawaguchi, Koichi Nishiyama, Koichi Ito, Toshu Inoue","doi":"10.1007/s10384-026-01380-x","DOIUrl":"10.1007/s10384-026-01380-x","url":null,"abstract":"Purpose: To investigate the association between current smoking and thyroid eye disease (TED), and diplopia among TED patients.Study design: Retrospective case-control study.Methods: This study included 12,038 individuals (10,269 with TED and 1769 controls) from a single ophthalmology center in Japan. Smoking status, demographic characteristics, and clinical features were obtained from medical records. Multivariable logistic regression was performed to evaluate the associations between current smoking and (1) TED diagnosis and (2) diplopia among TED patients, adjusting for age, sex, TSAb levels, and family history of thyroid disease, with stratified analyses by age and sex.Results: Current smoking was significantly associated with TED (adjusted odds ratio [aOR] = 1.41; 95% CI 1.24-1.61; p < 0.01), with significant effects observed in both sexes and a stronger association in males (aOR = 1.61) than in females (aOR = 1.36). Among TED patients, current smoking was also associated with diplopia (aOR = 1.45; 95% CI 1.29-1.62; p < 0.01), significantly in females (aOR = 1.57; p < 0.01) but not in males (aOR = 1.20; p = 0.09). The association with diplopia was not statistically significant in patients aged 60 years and older.Conclusions: Current smoking is significantly associated with both the development and severity of TED, including diplopia, in a Japanese population. These findings support the integration of smoking cessation counseling with the routine management of patients with thyroid disease.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1106-1114"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular microvascular alterations in patients with heart failure with preserved ejection fraction. 保留射血分数的心力衰竭患者的眼微血管改变。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-05-30 DOI: 10.1007/s10384-026-01381-w

Yoichiro Shinohara, Masaru Obokata, Ryo Mukai, Kosuke Nakamura, Hideo Akiyama

{"title":"Ocular microvascular alterations in patients with heart failure with preserved ejection fraction.","authors":"Yoichiro Shinohara, Masaru Obokata, Ryo Mukai, Kosuke Nakamura, Hideo Akiyama","doi":"10.1007/s10384-026-01381-w","DOIUrl":"10.1007/s10384-026-01381-w","url":null,"abstract":"Purpose: To investigate ocular circulation characteristics and their association with cardiac function in patients with heart failure with preserved ejection fraction (HFpEF).Study design: Prospective observational study.Methods: This prospective study included 15 patients with and 15 individuals without HFpEF. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), central choroidal thickness (CCT), laser speckle flowgraphy (LSFG), and optical coherence tomography angiography (OCTA) were assessed. LSFG was performed to evaluate blood flow in the optic nerve head (ONH) and macula; OCTA was performed to evaluate macular microvascular parameters. Patients with HFpEF underwent echocardiography to evaluate their cardiac function.Results: Mean blur rate (MBR), a blood flow parameter of LSFG, in HFpEF eyes was significantly reduced in the ONH and macula compared with individuals without HFpEF (p=0.0002; ONH, p=0.0012; macula). ONH-MBR correlated with E/e', a marker for left ventricular diastolic dysfunction measured using echocardiography (r=-0.67, p=0.011). The foveal avascular zone, measured using OCTA, was significantly enlarged in patients with HFpEF (p=0.018) and correlated with BCVA (r=0.58, p=0.0009). CRT and CCT in patients with HFpEF were significantly thinner compared with those in individuals without HFpEF (p=0.011, CRT; p=0.010, CCT).Conclusion: Ocular circulatory and chorioretinal structural changes may be detectable in patients with HFpEF using LSFG and OCT/OCTA.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1137-1146"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern of uveitis in first-time patients at a tertiary referral center in Saitama, Japan. 日本埼玉县三级转诊中心首次患者的葡萄膜炎模式。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-06-11 DOI: 10.1007/s10384-026-01382-9

Ryo Taguchi, Mai Yano, Kaon Nishimura, Yugo Hiranuma, Yoshinari Saima, Shingen Mito, Yoshiaki Tanaka, Machiko Shimmura, Hiroko Takano, Akihiro Kakehashi, Toshikatsu Kaburaki

{"title":"Pattern of uveitis in first-time patients at a tertiary referral center in Saitama, Japan.","authors":"Ryo Taguchi, Mai Yano, Kaon Nishimura, Yugo Hiranuma, Yoshinari Saima, Shingen Mito, Yoshiaki Tanaka, Machiko Shimmura, Hiroko Takano, Akihiro Kakehashi, Toshikatsu Kaburaki","doi":"10.1007/s10384-026-01382-9","DOIUrl":"10.1007/s10384-026-01382-9","url":null,"abstract":"Purpose: The distribution of uveitis varies worldwide and changes over time. Although nationwide surveys in Japan report shifts in disease patterns, updated epidemiological data after 2020 remain limited. In this study, we investigated the current pattern of uveitis among first-time patients at a regional university hospital in Japan and compared the findings with previous nationwide surveys.Study design: Retrospective observational study.Methods: We retrospectively reviewed the medical records of patients with uveitis who first visited Saitama Medical Center, Jichi Medical University, between January 1, 2020, and December 31, 2023. Collected data included age, sex, diagnosis, and anatomical classification of uveitis.Results: A total of 671 patients were included, with a mean age of 57.8 ± 21.1 years. Panuveitis was the most common anatomical subtype (55.0%), followed by anterior (34.9%), posterior (9.4%), and intermediate uveitis (0.7%). Definitive diagnoses were established in 62.7% of patients. The most frequent etiologies were sarcoidosis (9.7%), Vogt-Koyanagi-Harada disease (8.2%), herpetic iritis (6.3%), intraocular lymphoma (4.5%), and Behçet's disease (3.7%). Compared with previous nationwide surveys, higher proportions of cytomegalovirus retinitis (CMVR) and intraocular lymphoma were found.Conclusion: The findings in this study provide updated epidemiological data on uveitis in Japan, revealing higher proportions of CMVR and intraocular lymphoma among first-time patients at a regional university hospital. These trends might reflect population aging and an increasing number of immunocompromised patients, including those receiving immunosuppressive therapy or having hematologic malignancies.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1260-1270"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in childhood myopia over a 5-year interval: Korea national health and nutrition examination survey 2016 and 2021. 儿童近视的5年趋势：2016年和2021年韩国国家健康和营养检查调查。

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-06-11 DOI: 10.1007/s10384-026-01379-4

Dong Gyu Na, Dae Hee Kim

{"title":"Trends in childhood myopia over a 5-year interval: Korea national health and nutrition examination survey 2016 and 2021.","authors":"Dong Gyu Na, Dae Hee Kim","doi":"10.1007/s10384-026-01379-4","DOIUrl":"10.1007/s10384-026-01379-4","url":null,"abstract":"Purpose: To investigate changes in myopia over a 5-year interval during childhood using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016 and 2021.Study design: Cross-sectional analysis based on nationally representative KNHANES data.Methods: Participants aged 5-15 years from the 2016 KNHANES and 10-20 years from the 2021 KNHANES were included. Refractive errors were converted to spherical equivalents (SE) for comparison, and the more myopic eye was analyzed. SE percentiles were calculated across the entire refractive spectrum, ranging from hyperopia to myopia. SE differences were assessed by comparing the 2016 data with the corresponding 2021 data for participants who were 5 years older. Those with previous ocular surgery were excluded.Results: A total of 1005 participants from 2016 and 576 from 2021 were analyzed. Mean SE was -1.62 ± 2.05 D in 2016 and -2.96 ± 2.73 D in 2021 (p < 0.001). Among participants aged 5-10 and 12-13 years in 2016, SE values differed significantly from age-matched participants in 2021 (p < 0.05 for each group). Participants aged 5-10 years in 2016 within the 50th-90th percentile range showed SE changes exceeding -1.0 D compared with their 2021 counterparts. Greater myopic changes were observed in younger participants and in those with higher baseline myopia percentiles.Conclusion: This cross-sectional comparison indicates that children with a younger baseline age and higher baseline myopia percentiles experience greater myopic changes over a 5-year interval, emphasizing the need for early myopia control.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1046-1052"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy. Fuchs内皮性角膜营养不良患者主观症状与严重程度的关系

IF 2.7 3区医学

Japanese Journal of Ophthalmology Pub Date : 2026-09-01 Epub Date: 2026-07-03 DOI: 10.1007/s10384-026-01391-8

Yo Koizumi, Yoshinori Oie, Sayo Maeno, Nozomi Nishida, Chifune Kai, Rei Kamuro, Kazunori Miyata, Hideaki Yokogawa, Natsuko Mori, Akira Kobayashi, Hideki Fukuoka, Chie Sotozono, Masakazu Yamada, Takahiko Hayashi, Takefumi Yamaguchi, Atsushi Shiraishi, Satoru Nakatani, Masahiro Yamaguchi, Tomohiko Usui, Masatoshi Hirayama, Ryo Kawasaki, Kohji Nishida

{"title":"Association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy.","authors":"Yo Koizumi, Yoshinori Oie, Sayo Maeno, Nozomi Nishida, Chifune Kai, Rei Kamuro, Kazunori Miyata, Hideaki Yokogawa, Natsuko Mori, Akira Kobayashi, Hideki Fukuoka, Chie Sotozono, Masakazu Yamada, Takahiko Hayashi, Takefumi Yamaguchi, Atsushi Shiraishi, Satoru Nakatani, Masahiro Yamaguchi, Tomohiko Usui, Masatoshi Hirayama, Ryo Kawasaki, Kohji Nishida","doi":"10.1007/s10384-026-01391-8","DOIUrl":"10.1007/s10384-026-01391-8","url":null,"abstract":"Purpose: To investigate the association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy (FECD).Study design: Observational case series.Methods: This study included patients with FECD registered in the Japanese National FECD registry with recorded subjective symptoms, including morning blur, ocular pain, visual disturbance, and glare. Severity assessments included central corneal thickness (CCT) and modified Krachmer grading using the more severely affected eye with greater CCT for each patient. The area under the curve (AUC) was used to evaluate the predictive ability of subjective symptoms based on disease severity.Results: This study included 137 cases (mean age: 69±11 years; men, n=32) with subjective symptom records. The threshold values of CCT for predicting subjective symptoms based on the Youden index were 623 µm for morning blur compared to that at night (AUC, 0.76), 653 µm for ocular pain (AUC, 0.79), 623 µm for visual disturbance (AUC, 0.69), and 581 µm for glare (AUC, 0.60). The threshold values of the modified Krachmer grading for predicting subjective symptoms were grade 5 for morning blur compared to that at night (AUC, 0.85), and grade 6 for ocular pain (AUC, 0.79), grade 5 for visual disturbance (AUC, 0.72), and grade 4 for glare (AUC, 0.70).Conclusion: The predictive ability of subjective symptoms based on disease severity in patients with FECD was relatively high using the modified Krachmer grading. The severity threshold for each subjective symptom was considered helpful in deciding on interventional treatment.","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1066-1072"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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