Japanese Journal of Ophthalmology最新文献

{"title":"Pattern of uveitis in first-time patients at a tertiary referral center in Saitama, Japan.","authors":"Ryo Taguchi, Mai Yano, Kaon Nishimura, Yugo Hiranuma, Yoshinari Saima, Shingen Mito, Yoshiaki Tanaka, Machiko Shimmura, Hiroko Takano, Akihiro Kakehashi, Toshikatsu Kaburaki","doi":"10.1007/s10384-026-01382-9","DOIUrl":"10.1007/s10384-026-01382-9","url":null,"abstract":"<p><strong>Purpose: </strong>The distribution of uveitis varies worldwide and changes over time. Although nationwide surveys in Japan report shifts in disease patterns, updated epidemiological data after 2020 remain limited. In this study, we investigated the current pattern of uveitis among first-time patients at a regional university hospital in Japan and compared the findings with previous nationwide surveys.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of patients with uveitis who first visited Saitama Medical Center, Jichi Medical University, between January 1, 2020, and December 31, 2023. Collected data included age, sex, diagnosis, and anatomical classification of uveitis.</p><p><strong>Results: </strong>A total of 671 patients were included, with a mean age of 57.8 ± 21.1 years. Panuveitis was the most common anatomical subtype (55.0%), followed by anterior (34.9%), posterior (9.4%), and intermediate uveitis (0.7%). Definitive diagnoses were established in 62.7% of patients. The most frequent etiologies were sarcoidosis (9.7%), Vogt-Koyanagi-Harada disease (8.2%), herpetic iritis (6.3%), intraocular lymphoma (4.5%), and Behçet's disease (3.7%). Compared with previous nationwide surveys, higher proportions of cytomegalovirus retinitis (CMVR) and intraocular lymphoma were found.</p><p><strong>Conclusion: </strong>The findings in this study provide updated epidemiological data on uveitis in Japan, revealing higher proportions of CMVR and intraocular lymphoma among first-time patients at a regional university hospital. These trends might reflect population aging and an increasing number of immunocompromised patients, including those receiving immunosuppressive therapy or having hematologic malignancies.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1260-1270"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in childhood myopia over a 5-year interval: Korea national health and nutrition examination survey 2016 and 2021.","authors":"Dong Gyu Na, Dae Hee Kim","doi":"10.1007/s10384-026-01379-4","DOIUrl":"10.1007/s10384-026-01379-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate changes in myopia over a 5-year interval during childhood using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016 and 2021.</p><p><strong>Study design: </strong>Cross-sectional analysis based on nationally representative KNHANES data.</p><p><strong>Methods: </strong>Participants aged 5-15 years from the 2016 KNHANES and 10-20 years from the 2021 KNHANES were included. Refractive errors were converted to spherical equivalents (SE) for comparison, and the more myopic eye was analyzed. SE percentiles were calculated across the entire refractive spectrum, ranging from hyperopia to myopia. SE differences were assessed by comparing the 2016 data with the corresponding 2021 data for participants who were 5 years older. Those with previous ocular surgery were excluded.</p><p><strong>Results: </strong>A total of 1005 participants from 2016 and 576 from 2021 were analyzed. Mean SE was -1.62 ± 2.05 D in 2016 and -2.96 ± 2.73 D in 2021 (p < 0.001). Among participants aged 5-10 and 12-13 years in 2016, SE values differed significantly from age-matched participants in 2021 (p < 0.05 for each group). Participants aged 5-10 years in 2016 within the 50th-90th percentile range showed SE changes exceeding -1.0 D compared with their 2021 counterparts. Greater myopic changes were observed in younger participants and in those with higher baseline myopia percentiles.</p><p><strong>Conclusion: </strong>This cross-sectional comparison indicates that children with a younger baseline age and higher baseline myopia percentiles experience greater myopic changes over a 5-year interval, emphasizing the need for early myopia control.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1046-1052"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy.","authors":"Yo Koizumi, Yoshinori Oie, Sayo Maeno, Nozomi Nishida, Chifune Kai, Rei Kamuro, Kazunori Miyata, Hideaki Yokogawa, Natsuko Mori, Akira Kobayashi, Hideki Fukuoka, Chie Sotozono, Masakazu Yamada, Takahiko Hayashi, Takefumi Yamaguchi, Atsushi Shiraishi, Satoru Nakatani, Masahiro Yamaguchi, Tomohiko Usui, Masatoshi Hirayama, Ryo Kawasaki, Kohji Nishida","doi":"10.1007/s10384-026-01391-8","DOIUrl":"10.1007/s10384-026-01391-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy (FECD).</p><p><strong>Study design: </strong>Observational case series.</p><p><strong>Methods: </strong>This study included patients with FECD registered in the Japanese National FECD registry with recorded subjective symptoms, including morning blur, ocular pain, visual disturbance, and glare. Severity assessments included central corneal thickness (CCT) and modified Krachmer grading using the more severely affected eye with greater CCT for each patient. The area under the curve (AUC) was used to evaluate the predictive ability of subjective symptoms based on disease severity.</p><p><strong>Results: </strong>This study included 137 cases (mean age: 69±11 years; men, n=32) with subjective symptom records. The threshold values of CCT for predicting subjective symptoms based on the Youden index were 623 µm for morning blur compared to that at night (AUC, 0.76), 653 µm for ocular pain (AUC, 0.79), 623 µm for visual disturbance (AUC, 0.69), and 581 µm for glare (AUC, 0.60). The threshold values of the modified Krachmer grading for predicting subjective symptoms were grade 5 for morning blur compared to that at night (AUC, 0.85), and grade 6 for ocular pain (AUC, 0.79), grade 5 for visual disturbance (AUC, 0.72), and grade 4 for glare (AUC, 0.70).</p><p><strong>Conclusion: </strong>The predictive ability of subjective symptoms based on disease severity in patients with FECD was relatively high using the modified Krachmer grading. The severity threshold for each subjective symptom was considered helpful in deciding on interventional treatment.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1066-1072"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical procedures and outcomes in patients with tear drainage system disorders associated with the anticancer agent S-1.","authors":"Tsugihisa Sasaki, Tsutomu Sounou, Tomomi Higashide","doi":"10.1007/s10384-026-01377-6","DOIUrl":"10.1007/s10384-026-01377-6","url":null,"abstract":"<p><strong>Purpose: </strong>S-1 is a first-line oral anti-cancer drug widely used in Japan. This study evaluated surgical outcomes for S-1-associated tear drainage system disorders (S-1/TDSD) and explored strategies to improve outcomes.</p><p><strong>Study design: </strong>Multicenter, retrospective observational study.</p><p><strong>Methods: </strong>Fifty-one patients (89 sides; 31 men and 20 women; mean age ± SD, 68.7 ± 10.7 years; range 49─85 years) with S-1/TDSD were included. Surgical procedures performed were: three-snip procedure; exploratory horizontal part canaliculotomy; probing with tube placement; and conjunctivodacryocystorhinostomy with Jones tube insertion.</p><p><strong>Results: </strong>The cases were classified as: punctal occlusion (Group a, 34 sides), both stenosed canaliculi (Group b, 2 sides), patent canaliculus and mono-canalicular obstruction (CO) (Group c, 9 sides), one soft or tightCO and contralateral softCO (Group d, 13 sides), tightCOs in both canaliculi (Group e, 27 sides), and common CO (Group f, 4 sides). The three-snip procedure for Group a was successful in 32 of 34 sides (94.1%). Probing with intubation for Group b was successful in all cases (2/2). Conjunctivodacryocystorhinostomy for Group e was successful in 15 of 20 sides (75.0%) and dacryoendoscopic canaliculo-incision for Group e was successful in 4 of 4 sides (100%). However, exploratory horizontal part canaliculotomy and probing for Groups c and d were successful in 14%─42% of cases.</p><p><strong>Conclusion: </strong>The three-snip procedure for punctal occlusions showed favorable outcomes but procedures preserving the canaliculus, especially in patients with horizontal CO, did not yield good results, even for an affected single canaliculus.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1099-1105"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide patterns of cataract surgery in Japan: facility-level volume and outpatient versus inpatient procedures using the National Database of Health Insurance Claims (NDB).","authors":"Susumu Kunisawa, Yuichi Imanaka","doi":"10.1007/s10384-026-01416-2","DOIUrl":"https://doi.org/10.1007/s10384-026-01416-2","url":null,"abstract":"<p><strong>Purpose: </strong>Cataract surgery is among the most commonly performed types of surgery in Japan, but the actual surgical volume at the healthcare facility level remains unclear. This is partly because a substantial number of cataract surgical procedures are performed in clinics, making comprehensive investigation of relevant data difficult. This study used the National Database of Health Insurance Claims (NDB) to elucidate the number of surgical procedures, including outpatient procedures, performed at the facility level.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Using NDB data, we determined the number of cataract surgical procedures performed at the facility level over a 9-year period (fiscal years 2016-2024). We also analyzed the proportion of procedures performed in outpatient settings.</p><p><strong>Results: </strong>Approximately 4,500 facilities performed cataract surgery each year, with the number of facilities increasing. Although variations were observed across prefectures, no systematic regional patterns emerged. In most regions, facilities typically performed 100-300 procedures per year. Many facilities operate entirely at outpatient settings, while others operate entirely at inpatient settings. Facility-level outpatient practice patterns varied substantially across procedure-volume categories. This descriptive pattern was observed across the 9-year period.</p><p><strong>Conclusions: </strong>These nationwide facility-level data provide an important baseline for understanding cataract surgery practice in Japan. These findings may support future research and health policy discussions on cataract surgery practice across healthcare facilities.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of the choroidal thickness-to-axial length ratio in primary angle-closure disease.","authors":"Mika Suda, Daphne Viel Tsuru, Kenji Kashiwagi","doi":"10.1007/s10384-026-01353-0","DOIUrl":"10.1007/s10384-026-01353-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the role of choroidal thickness (CT) in primary angle-closure disease (PACD).</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>This retrospective observational study included fifty-one eyes-thirteen with acute primary angle-closure (APAC) with resolved glaucoma attack, twelve with primary angle-closure suspect (PACS), and twenty-six age- and sex-matched controls. Two blinded observers independently measured CT using swept-source optical coherence tomography (SS-OCT) at the subfovea and eight peripheral locations following the Margolis and Spaide method. In addition to routine ophthalmic examinations, the axial length (AL), anterior chamber depth (ACD), and lens vault (LV) were analyzed. Multivariable regression was used to identify associated factors, and the most effective parameters for discriminating PACD were investigated.</p><p><strong>Results: </strong>Subfoveal CT (SFCT) was significantly greater in the APAC (293.4 ± 103.7 µm) and PACS (283.8 ± 71.9 µm) groups than in the control group (210.8 ± 77.2 µm; p < 0.05). AL and age were each independently negatively associated with SFCT (p < 0.05). The CT/AL ratio was significantly greater in both PACD groups than in the control group. This ratio demonstrates superior discriminatory performance compared with absolute CT values in distinguishing eyes affected by PACD from normal eyes. The combination of ACD and LV yielded the highest diagnostic performance (area under the curve: 0.96), with a similar level of performance observed for the combination of the AL and the CT/AL ratio (area under the curve: 0.93).</p><p><strong>Conclusion: </strong>Compared with normal eyes, eyes affected by PACD exhibit increased CT and a significantly higher CT/AL ratio. The CT/AL ratio, a novel anatomical index, may provide a normalized metric reflecting choroidal expansion relative to globe size and may serve as a potential structural marker for PACD risk assessment.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1182-1189"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for tube exposure following Baerveldt glaucoma implantation and overlying tissue thickness assessed by anterior segment optical coherence tomography.","authors":"Natsumi Murata, Sachi Kojima, Yuji Takihara, Eri Takahashi, Kei-Ichi Nakashima, Toshihiro Inoue","doi":"10.1007/s10384-026-01366-9","DOIUrl":"10.1007/s10384-026-01366-9","url":null,"abstract":"<p><strong>Purpose: </strong>We identified clinical factors associated with tube exposure following Baerveldt glaucoma implantation (BGI) and used anterior segment optical coherence tomography (AS-OCT) to assess postoperative tissue thickness over the tube.</p><p><strong>Study design: </strong>Retrospective, single-center cohort study.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, 405 eyes underwent BGI (BG101-350) with preserved scleral patch grafts between October 2014 and December 2022. Tube exposure was documented through clinical records and slit-lamp examination. Risk factors were evaluated using Firth's penalized logistic regression. Overlying tissue thickness at 1 year postoperatively was measured via AS-OCT, and its association with clinical variables was analyzed using linear regression.</p><p><strong>Results: </strong>The mean follow-up was 630.7 days, and tube exposure occurred in 12 eyes (2.96%). Neovascular glaucoma (NVG) (odds ratio [OR] 5.03, p = 0.033) and anterior chamber (AC) tube insertion (OR 6.07, p = 0.017) were independently associated with exposure. Overlying tissue was significantly thinner with AC insertion compared with ciliary sulcus or pars plana placement (Kruskal-Wallis with Bonferroni-adjusted Dunn's tests; AC vs sulcus, p = 0.039; AC vs pars plana, p < 0.001). Among eyes with AC insertion, prior micropulse transscleral cyclophotocoagulation (MP-CPC) was associated with greater tissue thickness (estimate 0.173; p = 0.032).</p><p><strong>Conclusion: </strong>AC insertion and NVG were associated with an increased risk of tube exposure after BGI. AS-OCT revealed thinner tissue over AC-placed tubes, providing a structural basis for this risk. Avoiding AC insertion may reduce exposure; the observed association between prior MP-CPC and thicker tissue requires prospective validation.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1208-1217"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of refraction, presbyopia, and dry eye-related parameters between monofocal and multifocal contact lens users.","authors":"Masahiko Ayaki, Akiko Hanyuda, Kazuno Negishi","doi":"10.1007/s10384-026-01384-7","DOIUrl":"10.1007/s10384-026-01384-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate factors associated with multifocal contact lens (CL) use or prescription for presbyopia correction.</p><p><strong>Study design: </strong>Retrospective cross-sectional METHODS: Overall, 3264 CL users were assessed and categorized into three age groups; 40s (aged 40-49 years), 50s (aged 50-59 years), and 60s (aged 60-69 years). Refraction, near add power, dry eye-related parameters, and visual acuity were compared between monofocal and multifocal CL users in each age group. The odds ratios of factors for using multifocal CLs were calculated.</p><p><strong>Results: </strong>Multifocal CL users tended to be older across all age groups and were more likely to be male, aged in their 40s and 50s, and have lower degrees of myopia and astigmatism. In the 50s and 60s groups, multifocal CL users also showed better CL-corrected visual acuity, smaller differences between best-corrected and CL-corrected vision, and less under-correction. Near addition of CL was significantly higher in multifocal CL users in the 40s group. Among dry eye-related parameters, multifocal CL users had higher Schirmer values in the 40s and 60s groups, longer tear break-up time in the 50s group, and fewer keratopathies in the 40s and 50s groups. Odds ratios for multifocal CL use were significant for age, spherical equivalent, and astigmatism across all age groups, Schirmer values in the 40s and 50s groups, and tear break-up time and keratopathy were significantly higher in the 50s group.</p><p><strong>Conclusion: </strong>Multifocal CLs were more likely to be prescribed for users with lower refractive errors and healthier ocular surfaces. The current findings may contribute to optimizing CL prescriptions and presbyopia management strategies.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1053-1058"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of liquid-based cytology and cell block obtained by vitrectomy under infusion to diagnose vitreoretinal lymphoma.","authors":"Rintaro Ohe, Sonoka Oyanagi, Eriko Inamura, Takumi Kitaoka, Takanobu Kabasawa, Kazushi Suzuki, Naoya Uchiyama, Ami Shida, Toshinori Suzuki, Keita Togashi, Yutaka Kaneko","doi":"10.1007/s10384-026-01389-2","DOIUrl":"10.1007/s10384-026-01389-2","url":null,"abstract":"<p><strong>Purpose: </strong>To confirm the definitive diagnostic method of vitreoretinal lymphoma by vitrectomy under infusion.</p><p><strong>Study design: </strong>Retrospective, pathological analysis METHODS: Twenty-two patients participated in this study; 29 vitreous samples were obtained under infusion. Liquid-based cytology (LBC) was performed by targeting areas with a high cell concentration while observing the surgical field under infusion. Cell block analysis was performed by the vitreous cell components in the intraocular irrigating fluid.</p><p><strong>Results: </strong>Our vitreous sample collection did not result in adverse events. In LBC samples, atypical large lymphoid cells were identified in 89.7%. These samples contained between 30 and over 10,000 atypical large lymphoid cells. Necrosis was observed in 76.9% in the background of LBC samples. In cell block samples, atypical large lymphoid cells were identified in 87.0%. Immunohistochemical staining revealed the following immunophenotypes for the lymphoid cells: CD20 (100%), CD79a (100%), CD10 (0%), BCL6 (57.1%), MUM1 (85.7%), and Ki-67 LI 66.3±12.7%.</p><p><strong>Conclusion: </strong>This method ensures safety and high diagnostic accuracy, thereby contributing to the definitive diagnosis of vitreoretinal lymphoma.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1271-1277"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148351954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anterior scleral thickness in pachychoroid pigment epitheliopathy, central serous chorioretinopathy and pachychoroid neovasculopathy.","authors":"Arzu Nur Şahin Şekerci, Ali Şemsi Atalay, Enise Kübra Cankı, Semra Koca","doi":"10.1007/s10384-026-01373-w","DOIUrl":"10.1007/s10384-026-01373-w","url":null,"abstract":"<p><strong>Purpose: </strong>To compare anterior scleral thickness (AST) among pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV) and healthy controls.</p><p><strong>Study design: </strong>Retrospective cross-sectional study.</p><p><strong>Methods: </strong>This single-center, retrospective cross-sectional study included 73 eyes of 72 patients with pachychoroid spectrum disease (PPE (n = 35), CSC (n = 25), PNV (n = 12)) and 29 control eyes. All participants underwent comprehensive ophthalmic examination and swept-source optic coherence tomography (OCT) (Topcon DRI-OCT Triton). Choroidal thickness (CT) was measured subfoveally, at 500 and 1000 μm nasal/temporal to the fovea, and sublesionally. AST was measured with the anterior segment mode 6 mm posterior to the scleral spur in four quadrants.</p><p><strong>Results: </strong>CT was significantly greater in CSC than in PPE, PNV, and controls at all macular locations (all p < 0.001). Sublesional CT differed among pachychoroid groups (p = 0.005), with CSC thicker than PPE (p = 0.002) and PNV (p = 0.011); PPE and PNV did not differ (p = 1.000). Anterior scleral thickness was significantly greater in all quadrants in the pachychoroid groups compared with controls (p < 0.001). Superior AST was greater in PPE than PNV (p = 0.044); other inter-pachychoroid comparisons were not significant (p > 0.05). In multivariate linear regression model, the presence of pachychoroid spectrum disease was independently associated with thicker AST after adjustment for age, sex, AXL, and SE (p< 0.001 for all quadrants).</p><p><strong>Conclusion: </strong>Eyes with pachychoroid spectrum disease exhibit increased AST relative to controls, while diffuse CT thickening is most pronounced in CSC. These findings support a pathophysiologic association between scleral structure and choroidal venous overload in pachychoroid disorders and highlight AST as a potential structural biomarker.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1122-1129"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}