Japanese Journal of Ophthalmology最新文献

{"title":"En-face quantitative evaluation using ultra-high-resolution OCT of hyperreflective foci in neovascular age-related macular degeneration.","authors":"Iori Wada, Shintaro Nakao, Satomi Shiose, Yoshihiro Kaizu, Muneo Yamaguchi, Keijiro Ishikawa, Kohei Kiyohara, Tatsuro Ishibashi, Koh-Hei Sonoda","doi":"10.1007/s10384-025-01219-x","DOIUrl":"10.1007/s10384-025-01219-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study quantifies hyperreflective foci (HRFs) in neovascular age-related macular degeneration (nAMD) before and after anti-VEGF therapy in the initial loading phase using en-face ultra-high-resolution spectral domain OCT (UHR-SD-OCT), investigating their correlation with clinical findings.</p><p><strong>Study design: </strong>Retrospective observational study METHODS: This retrospective study included 30 eyes from 30 patients with treatment-naïve nAMD. The patients received monthly intravitreal injections of anti-VEGF therapy for three months as the initial loading phase. At each visit, comprehensive ophthalmic examinations were conducted. HRFs were quantified using our custom-developed software from an en-face UHR-SD-OCT. The number of HRFs was compared before and after the loading phase and investigated the relationship with best-corrected visual acuity (BCVA), greatest linear dimension (GLD), macular neovascularization (MNV) size and incidence of macular atrophy (MA).</p><p><strong>Results: </strong>This evaluation system showed a significant reduction in the number of HRFs after anti-VEGF therapy compared to before the loading phase (p < 0.0001). The number of pre-treatment HRFs significantly correlated with pre-treatment BCVA, GLD, and MNV size. The number of post-treatment HRFs significantly correlated with pre-treatment GLD and pre-treatment MNV size. Additionally, patients who developed MA two years after treatment initiation exhibited significantly higher counts of pre-treatment HRFs compared to those without the MA development (465.7 ± 187.0 vs. 212.9 ± 93.8, p < 0.05).</p><p><strong>Conclusions: </strong>Quantification of HRF using en-face UHR-SD-OCT may be a useful clinical biomarker during anti-VEGF therapy in nAMD.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"738-744"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal irregularity of the anterior and posterior surface in patients with limbal stem cell deficiency evaluated with anterior-segment optical coherence tomography.","authors":"Hiroki Goto, Takashi Ono, Yukako Taketani, Yuito Abe, Mikiko Kimakura, Tetsuya Toyono, Makoto Aihara, Takashi Miyai","doi":"10.1007/s10384-025-01242-y","DOIUrl":"10.1007/s10384-025-01242-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate corneal anterior and posterior irregularities due to limbal stem cell deficiency (LSCD) based on staging using Fourier harmonic analysis with anterior segment optical coherence tomography (AS-OCT).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Patients with LSCD and those without anterior segment disease (controls), examined using AS-OCT, were retrospectively included. Based on Fourier harmonic analysis of the central 3 mm, spherical components, regular astigmatism, asymmetry components, and higher-order irregularities of the anterior, posterior, and total corneas were compared between the groups.</p><p><strong>Results: </strong>We analyzed 72 eyes of 72 patients-25 eyes of 25 patients (63.0 ± 15.8 years) with LSCD and 47 eyes of 47 patients (66.8 ± 9.5 years) in the control group. Regular astigmatism, asymmetry components, and higher-order irregularities of the anterior, posterior, and total corneas were higher in LSCD than in the control group (all P < 0.001). Based on LSCD staging, asymmetry components of the total cornea were higher in LSCD stages I, II, and III than in the controls (P = 0.034, P < 0.001, and P < 0.001, respectively). Additionally, higher-order irregularity was larger in stages II and III of LSCD than in the controls (all P < 0.001). The higher-order irregularity in LSCD significantly correlated with best-corrected visual acuity (P = 0.034).</p><p><strong>Conclusion: </strong>Corneal irregularities in the anterior and posterior corneas increased in patients with LSCD and contributed to best-corrected visual acuity. Even in patients at stage I, where the lesion spared the central 5 mm, an increase in asymmetric astigmatism within the central 3 mm was observed.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"708-716"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year effect of sequential argon-Nd:YAG prophylactic laser peripheral iridotomy on corneal endothelial cell density in Japanese eyes with narrow angles.","authors":"Koichi Mishima, Naomi Mataki, Hiroshi Murata, Shinichiro Ohtani, Hiroshi Sakai, Atsuo Tomidokoro, Makoto Aihara, Kazunori Miyata, Aiko Iwase, Makoto Araie","doi":"10.1007/s10384-025-01211-5","DOIUrl":"10.1007/s10384-025-01211-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of prophylactic sequential argon- Nd:YAG laser peripheral iridotomy (pLPI_sequential) on the corneal endothelial cell density (CECD) over 5 years in Japanese eyes with narrow angles (NA-eyes).</p><p><strong>Study design: </strong>Prospective observational study METHODS: The CECD of NA-eyes before and after pLPI_sequential and of untreated NA-eyes were assessed annually over 5 years with non-contact specular microscopy. Routine ophthalmic examinations and measurements using anterior-segment imaging devices were performed at baseline. The time courses of the CECD were analyzed using a multivariable linear mixed-effect model and factors obtained at baseline.</p><p><strong>Results: </strong>Sixty-nine pLPI_sequential-treated NA-eyes (69 subjects; mean age, 68.9 years) and 67 pLPI_sequential-untreated NA-eyes (67 subjects; mean age, 64.4 years) were enrolled. In the pLPI_sequential-untreated NA-eyes, no baseline factors were correlated significantly with the time course of the CECD, and its decline rate - 4.7 (95% Confidence interval (I: - 13.3 to 4.0) cells/mm² was not significant (p = 0.267). In the pLPI_sequential-treated NA-eyes, the CECD declined with marginal significance - 12.2 (- 24.7 to 0.3) cells/mm²/year (p = 0.0513) over 5 years. Higher laser energy used, thicker iris, and shallower central anterior chamber depth (cACD) at baseline were significantly negatively correlated with the post-laser CECD (p = 0.0092, 0.0119, and 0.0158). No significant difference was seen in the baseline factors-adjusted CECD decline rate (p = 0.262) between both the groups.</p><p><strong>Conclusion: </strong>Prophylactic sequential argon-Nd:YAG pLPI_sequential had no clinically significant effects on the time course of the CECD over 5 years in Japanese NA eyes. However, higher laser energy used, thicker iris, and shallower cACD significantly negatively affected the post-laser CECD.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"789-797"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors predictive of treatment outcomes in submacular hemorrhage secondary to age-related macular degeneration.","authors":"Yuto Watanabe, Takashi Koto, Aya Takahashi, Masaharu Mizuno, Tomoka Ishida, Kosuke Nakajima, Jun Takeuchi, Tadashi Yokoi, Makiko Nakayama, Annabelle A Okada, Makoto Inoue, Keiko Kataoka","doi":"10.1007/s10384-025-01207-1","DOIUrl":"10.1007/s10384-025-01207-1","url":null,"abstract":"<p><strong>Purpose: </strong>To identify predictors for visual outcomes of eyes with submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Clinical data from patients diagnosed with SMH secondary to nAMD and treated with pneumatic displacement were collected. SMH thickness was measured by optical coherence tomography (OCT) at baseline and 1 week. Possible factors associated with best-corrected visual acuity (BCVA) gain at 3 months were analyzed.</p><p><strong>Results: </strong>Fifty-six eyes of 56 patients (18 female/38 male; mean age, 77.8 ± 10.1 years) were analyzed; 34 were treatment-naïve and 22 were previously treated with anti-vascular endothelial growth factor agents. Multivariable analysis showed that greater BCVA gain more than 0.3 logMAR at 3 months post-treatment was associated with being treatment-naïve (odds ratio [OR], 34.30; 95% confidence interval [CI], 1.38-851.91; P = 0.031), thinner SMH thickness at 1 week after pneumatic displacement (OR, 0.38 per 50-unit increase; CI, 0.18-0.80; P = 0.011), and worse baseline BCVA (OR, 2.58 per 0.1-unit increase; CI, 1.31-5.07; P = 0.006), but not associated with age (OR, 0.50; 95% CI, 0.24-1.06), the time from onset to pneumatic displacement (OR, 1.04; 95%CI, 0.87-1.23), SMH thickness at baseline (OR, 0.92; 95%CI, 0.63-1.36), and the presence of subfoveal hemorrhagic PED (OR, 0.72; 95%CI, 0.08-6.84).</p><p><strong>Conclusion: </strong>This study identifies novel factors predictive of visual outcomes for pneumatic displacement for SMH due to nAMD. The presence of residual SMH at 1 week following unsuccessful pneumatic displacement may warrant further intervention.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"732-737"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of thyroid eye disease combined with myasthenia gravis.","authors":"Yi Wu, Yanxi Li, Weimin He","doi":"10.1007/s10384-025-01208-0","DOIUrl":"10.1007/s10384-025-01208-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical features and prognostic factors of patients with thyroid eye disease (TED) combined with myasthenia gravis (MG) at a tertiary comprehensive hospital in China during a 10-year period.</p><p><strong>Study design: </strong>retrospective study.</p><p><strong>Methods: </strong>A case series of patients diagnosed with TED combined with MG was conducted at a tertiary general hospital over 10 years. Medical records of general conditions, clinical presentation, imaging and laboratory tests, treatment modalities, and prognostic outcomes were reviewed.</p><p><strong>Results: </strong>Twenty-three patients with TED combined with MG were found throughout the study period. The mean age was 42.57 ± 14.89 years with 10 men and 13 women. Ocular motility disorders (82.61%), diplopia (73.91%), and ptosis (73.91%) were the primary clinical manifestations, and ocular motility disorders with limited movement in all directions were common (17 eyes) (50.00%). Active (69.57%) and moderate-to-severe (82.61%) TED was common, and hyperthyroidism was the most common complication of thyroid disease (57.17%). Ocular MG was the predominant subtype of MG (86.96%). Chest CT or pathologic examination identified thymic hyperplasia in 4 patients (17.39%) and thymoma in 1 patient (4.35%). A statistically significant association was observed between smoking and an unfavorable prognosis of TED combined with MG (P<0.05).</p><p><strong>Conclusions: </strong>MG should be taken into account in patients with TED who exhibit the following: unilateral or bilateral ptosis, ptosis in one eye and upper eyelid retraction in the other, obvious eye movement disorders without or with mild involvement of the extraocular muscles on imaging, and symptoms of morning and evening fluctuations. Ophthalmologists should refer these patients to the Department of Neurology to avoid misdiagnosis or underdiagnosis. The co-occurrence of TED and MG is rare clinically, mostly affecting young and middle-aged women, with ocular MG and hyperthyroidism as the main clinical subtype, and thymic hyperplasia or thymoma in a small percentage. Smoking is an independent risk factor for poor prognosis of TED combined with MG.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"766-774"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and bioinformatic analysis of RHO and PRPH2 variants in north Indian retinitis pigmentosa patients.","authors":"Aarti Bhardwaj, Jitender Phogat, Manoj Yadav, Anshu Yadav, Vishal Panghal, Mayank Singh, Sapna Sharma, Rakesh Kumar, Mukesh Tanwar","doi":"10.1007/s10384-025-01262-8","DOIUrl":"https://doi.org/10.1007/s10384-025-01262-8","url":null,"abstract":"<p><strong>Purpose: </strong>Retinitis Pigmentosa (RP) represents the most common form of inherited retinal dystrophy (IRD), identified by a gradual degeneration of photoreceptors, ultimately resulting in nyctalopia and impaired vision. This study was conducted to screen the rhodopsin and peripherin2 genes for possible pathogenic mutations in north Indian RP patients.</p><p><strong>Study design: </strong>We focused on assessing the whole coding region and the intron-exon boundaries of RHO and PRPH2 genes in RP patients and control subjects.</p><p><strong>Methods: </strong>After institutional human ethical clearance and informed consent, a total of seventy-five sporadic cases of RP and one hundred control subjects were enrolled in the current study. Genomic DNA was extracted from the peripheral blood samples of patients and control subjects. PCR-DNA sequencing was performed for coding exons and intron-exon boundaries of RHO and PRPH2 genes to identify nucleotide variations in patients and controls. The pathogenicity of identified missense variants was predicted by using six different bioinformatics tools. Structural changes of the protein were analyzed using Garnier-Osguthorpe-Robson, PyMol, ChimeraX, and Molecular Dynamic simulations.</p><p><strong>Results: </strong>A total of twenty sequence variants which include 7 missense, 3 synonymous and 10 intronic changes in RHO gene, and fourteen sequence variants which include 9 missense, 4 synonymous and 1 intronic variant in PRPH2 gene were identified. Bioinformatic analysis revealed two possible pathogenic missense mutations [p.(E150K) and p.(P347L)] in RHO gene and three possible pathogenic mutations [p.(G31D), p.(D84N), and p.(R220Q)] in PRPH2 gene. All five mutations have been previously reported and are documented in publicly available variant databases. Structural alterations were observed in the secondary and tertiary structures of the mutated proteins in cases of pathogenic changes both in rhodopsin and peripherin2 proteins. These structural changes led to protein dysfunction, contributing to disease progression.</p><p><strong>Conclusion: </strong>In our study population, we identified five previously reported potentially pathogenic missense variants in the RHO and PRPH2 genes, which are associated with retinitis pigmentosa. This data will add to the existing repertoire of disease-causing mutations.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term outcomes of the PreserFlo MicroShunt in Japanese patients with exfoliation glaucoma: a comparison with primary open-angle glaucoma using propensity score matching.","authors":"Teruki Yamae, Rei Sakata, Haruyuki Suzuki, Yurika Aoyama, Hotaka Nemoto, Hitomi Saito, Megumi Honjo, Shiroaki Shirato, Makoto Aihara","doi":"10.1007/s10384-025-01265-5","DOIUrl":"https://doi.org/10.1007/s10384-025-01265-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the efficacy and safety of initially implanted PreserFlo MicroShunt (PMS) in Japanese patients with exfoliation glaucoma (XFG). Using propensity score matching, intraocular pressure (IOP) control rates were compared between patients with XFG and primary open-angle glaucoma (POAG).</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>This study reviewed 31 eyes of 31 patients with XFG who underwent initial PMS implantation with mitomycin C. IOP, medication scores, and corneal endothelial cell density (CECD) were assessed preoperatively and at up to 6 months postoperatively. Kaplan-Meier analysis was used to estimate the 6-month survival rate, defined as an IOP reduction of > 20% from baseline and an IOP < 15 mmHg. The incidences of needling, reoperation, and complications were also assessed. IOP control was compared between XFG and propensity-score-matched POAG patients using the log-rank test.</p><p><strong>Results: </strong>At 6 months, the mean IOP had decreased significantly, from 22.3 ± 6.6 to 14.7 ± 6.6 mmHg, and the medication score had declined from 4.5 to 1.4. CECD decreased from 2127 to 1902 cells/mm², although this was not statistically significant. The complete success rate (without any glaucoma medications or intervention) was 48%. Postoperative complications included anterior chamber hemorrhage and choroidal detachment. Needling was performed in nine eyes (29.0%), and additional surgery was performed in five eyes (16.1%). Compared to POAG patients (11.9 mmHg), XFG patients had higher postoperative IOP (14.8 mmHg) and higher medication scores (0.5 vs 1.4, p = 0.04) and a lower success rate (62.2% vs 41.7%).</p><p><strong>Conclusions: </strong>PMS in Japanese patients with XFG resulted in a significant IOP reduction over 6 months, with a relatively favorable safety profile. However, its efficacy was slightly inferior to that in POAG, implying potential differences in PMS responsiveness between glaucoma subtypes.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and MRI differences in congenital fibrosis of extraocular muscles patients with KIF21A and TUBB3 variants.","authors":"Dan Wang, Hong-Yan Jia, Yi Liang, Qian Ma, Qing-Lin Chang, Ran-Ran Zhang, Yong-Hong Jiao","doi":"10.1007/s10384-025-01263-7","DOIUrl":"https://doi.org/10.1007/s10384-025-01263-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the clinical and neuroimaging phenotypes in Chinese patients with congenital fibrosis of extraocular muscles (CFEOM) harboring KIF21A versus TUBB3 variants.</p><p><strong>Study design: </strong>Retrospective, observational case series.</p><p><strong>Methods: </strong>A retrospective review of 37 CFEOM patients harboring mutations of KIF21A (n = 25) and TUBB3 (n = 12) with clinical examinations was performed. MRI was used to evaluate orbital, encephalic, and intracranial nerve integrity. The diameters of oculomotor nerve (CN3) and abducens nerves (CN6), the cross-section area (CSA) of the optic nerve (ON) and the volumes of extraocular muscles (EOMs) were measured in the mutant groups and normal control group (n = 20).</p><p><strong>Results: </strong>The CFEOM-KIF21A group had a slightly higher percentage of bilateral blepharoptosis (95% vs. 70%) and synergistic convergence (40% vs. 20%) compared with the CFEOM-TUBB3 group. The diameter of CN3 and the CSA of ON were significantly smaller in the mutant groups than the control. The median diameter of CN6 was smaller in the KIF21A group than in the TUBB3 group (P < 0.001). The median volumes of the superior rectus, lateral rectus, and inferior oblique muscle in the KIF21A group were significantly smaller than TUBB3 group. 10% of KIF21A families and 40% of TUBB3 families were accompanied by systemic congenital malformation (P = 0.070).</p><p><strong>Conclusion: </strong>Most of the CFEOM-KIF21A patients occur as isolated cases, tend to suffer a more severe ocular phenotype and CN6 hypoplasia. CFEOM-TUBB3 patients tend to present with syndromic CFEOM, systemic involvement is mainly associated with brain malformations, and appear to have a clear genotype-phenotype correlation.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual function and patient satisfaction with 3 types of monofocal plus intraocular lenses.","authors":"Ryota Kabura, Tetsuji Takeshita, Yukihira Yoshioka, Rumi Iwasaki, Hinako Amikawa, Minagi Yasukochi, Tetsuro Oshika","doi":"10.1007/s10384-025-01266-4","DOIUrl":"https://doi.org/10.1007/s10384-025-01266-4","url":null,"abstract":"<p><strong>Purpose: </strong>To compare visual function and patient-reported satisfaction among 3 types of monofocal plus intraocular lenses (IOLs) STUDY DESIGN: Retrospective case series METHODS: This study included 122 eyes from 61 patients who underwent bilateral implantation of DIB00V (Johnson & Johnson Vison Care, 22 patients), NSP-3 (Nidek, 18 patients), or XY1-EM (Hoya Surgical Optics, 21 patients) between July 2023 and October 2024. At 3 months postoperatively, corrected distance visual acuity (CDVA) at 5 m, distance-corrected intermediate visual acuity (DCIVA) at 70 cm and 50 cm, manifest refraction, and letter contrast sensitivity were compared. Responses to a questionnaire assessing subjective satisfaction with daily visual activities were analyzed.</p><p><strong>Results: </strong>No significant differences were observed among the 3 groups in CDVA at 5 m and DCIVA at 50 cm (P = .45, P = .12). DCIVA at 70 cm was significantly better with the XY1-EM than with the DIB00V (P <.01). Manifest refraction and letter contrast sensitivity showed no significant differences among the groups (P = .55, P = .88). A significant difference in satisfaction scores for night driving was found, with the DIB00V scoring higher than the NSP-3 (P <.05). Spectacle independence was achieved more frequently with the XY1-EM (81.0%) than with the DIB00V (63.6%) and NSP-3 (66.7%) (P <.05).</p><p><strong>Conclusions: </strong>The 3 monofocal plus IOLs demonstrated comparable visual function in terms of CDVA at 5 m, DCIVA at 50 cm, and letter contrast sensitivity. However, the XY1-EM exhibited significantly better DCIVA at 70 cm and a higher rate of spectacle independence.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching to faricimab alleviates persistent subretinal fluid and pigment epithelial detachment in neovascular age-related macular degeneration.","authors":"Yusuke Maehara, Shoji Notomi, Satomi Shiose, Yosuke Fukuda, Kohei Kiyohara, Kumiko Kano, Keijiro Ishikawa, Toshio Hisatomi, Koh-Hei Sonoda","doi":"10.1007/s10384-025-01264-6","DOIUrl":"https://doi.org/10.1007/s10384-025-01264-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate structural outcomes, including subretinal fluid (SRF) and fibrovascular pigment epithelial detachment (fvPED) volume changes, after switching from aflibercept 2 mg to faricimab in Japanese patients with neovascular age-related macular degeneration (nAMD).</p><p><strong>Study design: </strong>Retrospective, observational study.</p><p><strong>Methods: </strong>Patients with nAMD who were switched from aflibercept 2 mg to faricimab were enrolled. Changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), and the volumes of SRF and fvPED were analyzed using three-dimensional spectral-domain optical coherence tomography data.</p><p><strong>Results: </strong>A total of 46 eyes from 46 patients were included. All had been maintained on fixed dosing due to difficulty in extending the injection interval. Patients had received a mean of 25.6 aflibercept 2 mg injections, with a mean interval of 7.5 weeks for the last three injections. Subsequently, three faricimab injections were given at similar intervals (7.6 weeks). BCVA remained unchanged (p = 0.066), while CMT, SRF, and fvPED volumes significantly decreased (p < 0.01). A significant correlation was found between the reductions in SRF and fvPED volumes (p < 0.05).</p><p><strong>Conclusions: </strong>Switching to faricimab led to favorable structural outcomes in nAMD patients previously treated with aflibercept 2 mg, particularly by reducing SRF and fvPED.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}