Japanese Journal of Ophthalmology最新文献

{"title":"Visualization of porcine and human aqueous humor outflow tract anatomies with transparency enhancement.","authors":"Yuichi Asahina, Makoto Aihara, Takashi Miyai, Asami Tanaka, Hiroshi Onodera","doi":"10.1007/s10384-024-01151-6","DOIUrl":"10.1007/s10384-024-01151-6","url":null,"abstract":"<p><strong>Purpose: </strong>There is no established method for visualizing the three-dimensional (3D) structure of the aqueous humor outflow tract. This study attempted to visualize the 3D structures of porcine and human ocular tissues, particularly the aqueous humor outflow tract using a transparency reagent composed of 2, 2-thiodiethanol.</p><p><strong>Study design: </strong>Clinical and experimental.</p><p><strong>Methods: </strong>The porcine eyes were collected in Japan, and the human eyes were imported from the United States. The human eyes were obtained from a 64-year-old Caucasian woman, arriving 7 days after her death. The specimens were formalin-fixed upon arrival, fluorescently labeled, optically cleared using a transparency-enhancing reagent, and visualized using a confocal microscope.</p><p><strong>Results: </strong>Both porcine and human eyes were visualized to the extent that the choroidal vessels were observed on gross examination. The aqueous humor outflow tract was clearly observed as a luminal structure in the porcine eye, mainly depicted by autofluorescence, and in the human eyes as a luminal structure continuing from the trabecular meshwork without fluorescence.</p><p><strong>Conclusion: </strong>Observations using transparency-enhancing technology enabled us to obtain 3D images useful for visualizing ocular tissues, especially the aqueous humor outflow tract.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"460-468"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and structural analysis of pathogenic variants in MYOC and CYP1B1 genes in Indian JOAG patients.","authors":"Manoj Yadav, Mukesh Kumar, Chand Singh Dhull, Sumit Sachdeva, Aarti Bhardwaj, Anshu Yadav, Vishal Panghal, Pradeep Sharma, Ankit Kumari, Ritu Yadav, Mayank Singh, Rakesh Kumar, Anupama Deora, Manisha Rathi, Punit Kaur, Mukesh Tanwar","doi":"10.1007/s10384-025-01173-8","DOIUrl":"10.1007/s10384-025-01173-8","url":null,"abstract":"<p><strong>Purpose: </strong>Juvenile onset open-angle glaucoma (JOAG) manifests in individuals under the age of 40, resulting in elevated intraocular pressure and significant optic nerve damage. To broaden the spectrum of mutations associated with JOAG and to determine their specific structural implications, we examined Myocilin and Cytochrome P450 1B1 gene in a cohort of 111 unrelated North Indian patients diagnosed with JOAG.</p><p><strong>Study design: </strong>A clinical and experimental study.</p><p><strong>Methods: </strong>PCR-DNA sequencing screened the coding exons and intron-exon junctions of the MYOC and CYP1B1 genes in 111 unrelated JOAG patients and 100 controls. Identified sequence variations were searched in the ClinVar database, HGMD, and dbSNP. Six different online available algorithms including rare exome variant ensemble learner (REVEL), Sorting Intolerant From Tolerant (SIFT), Mutation Taster, SNAP2, IMutant2.0, and MutPred2 were used for the pathogenicity prediction of missense variations. The Structural consequences of detected possible pathogenic variations were predicted by using PyMol, Chimera and MD simulation of these changes.</p><p><strong>Results: </strong>Potentially-pathogenic variations were observed in thirty patients (27.02%) within the MYOC and CYP1B1 genes, encompassing both novel and previously documented variants. Structural predictions of novel potentially-pathogenic mutations indicate altered stability and flexibility.</p><p><strong>Conclusion: </strong>Analysis reveals a higher prevalence of CYP1B1 gene variants (22.5%) relative to MYOC gene variants (4.5%), suggesting that CYP1B1 is the predominant gene implicated in JOAG among Indian patients. Our findings enhance the understanding of mutation spectra and frequencies of MYOC and CYP1B1gene in JOAG among the North Indian population. Structural predictions of novel pathogenic mutations could enhance the understanding of JOAG pathogenesis and support subsequent functional analysis.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"469-481"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes and prognosis in vitrectomy with autologous platelet concentrate injection for large, high myopic, or recurrent macular holes.","authors":"Seo-Yeon Hong, Sang Un Yi, Mirinae Kim, Young-Hoon Park","doi":"10.1007/s10384-025-01166-7","DOIUrl":"10.1007/s10384-025-01166-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the long-term efficacy and safety of Autologous Platelet Concentrate (APC) injection as an adjunct to pars plana vitrectomy (PPV) in the treatment of macular holes (MHs) with a high risk of surgical failure, including large, highly myopic, or recurrent MHs.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>This study included patients who underwent PPV with or without APC injection for MHs at Seoul St. Mary's Hospital between March 2017 and February 2020, with a minimum postoperative follow-up period of 3 years. Anatomical success rates, alterations in foveal microstructure, and improvements in best-corrected visual acuity (BCVA) were evaluated.</p><p><strong>Results: </strong>Fifty-four patients were included, exhibiting a trend toward enhanced anatomical success in the PPV with APC group (95.0%) compared to the PPV with flap techniques (85.7%) and PPV without the adjunct of flap techniques or APC injection (84.6%), though not statistically significant. Significant findings included increased glial proliferation within the PPV with APC group, sustained for up to one year (P < 0.01), and a significant correlation between glial proliferation and MH closure (P = 0.032). Improvements in BCVA were substantial and found to be significantly associated with preoperative BCVA, the reconstruction of the external limiting membrane (ELM) and ellipsoid zone (EZ) (P = 0.008, 0.010, and 0.047, respectively).</p><p><strong>Conclusion: </strong>The use of APC as adjuvant to PPV can be advantageous in cases of challenging MHs, reflecting comparable anatomical success rates, potential for glial proliferation critical for hole closure, and established safety profile.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"387-394"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency and safety comparison between 20,000 and 10,000 cuts per minute vitrectomy using a 27G cutter in rhegmatogenous retinal detachment: a prospective randomized controlled study.","authors":"Yu-Te Huang, I Wang, Po-Yu Chen, Chi-Lan Yang, San-Ni Chen","doi":"10.1007/s10384-025-01167-6","DOIUrl":"10.1007/s10384-025-01167-6","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficac and safety of a dual-blade 20,000 cuts per minute (cpm) vitrectomy probe with a single-blade 10,000 cpm probe for primary rhegmatogenous retinal detachment (RRD).</p><p><strong>Study design: </strong>Prospective, randomized controlled clinical trial.</p><p><strong>Methods: </strong>Evaluations were conducted preoperatively, intraoperatively, and at three months postoperatively. The main outcome measure focused on the duration of core vitrectomy, with secondary outcomes including peripheral vitreous shaving duration, balanced salt solution (BSS) consumption, anatomical and functional outcomes, as well as the incidence of surgical procedure-related complications.</p><p><strong>Results: </strong>Overall, 35 cases in the 20,000 cpm group and 37 cases in the 10,000 cpm group completed the trial without significant differences in baseline demographic characteristics. The 20,000 cpm group demonstrated significantly shorter core vitrectomy duration (161.6 ± 10.4 vs. 206.8 ± 10.1 s) (P = 0.003) and peripheral vitreous shaving time (446.3 ± 20.3 vs. 544.2 ± 22.2 s) (P = 0.002) compared to the 10,000 cpm group. BSS consumption was higher in the 20,000 cpm group but without statistical significance (P = 0.231). There were no significant differences in the need for scleral sutures and the incidence of iatrogenic retinal breaks (P = 0.331 and 0.523). At the 3-month follow-up, there were no statistically significant differences in primary success, final anatomical success, or mean visual acuity (P > 0.9, P = 0.326). Rates of complications, including ocular hypertension, epiretinal membrane formation, and endophthalmitis also showed no statistically significant differences (P > 0.6).</p><p><strong>Conclusion: </strong>The utilization of the new-generation 27-gauge system with a 20,000 cpm probe may herald a new paradigm of high-flow, smaller-diameter instrumentation, thereby enhancing the efficiency of the small gauge technique.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"403-409"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular complication induced by anticancer drug S-1: association with drug concentrations in tears.","authors":"Masakazu Yamada, Tomoyuki Kamao, Atsushi Shiraishi, Jo Sakai, Yuichi Ohashi","doi":"10.1007/s10384-025-01180-9","DOIUrl":"10.1007/s10384-025-01180-9","url":null,"abstract":"<p><strong>Purpose: </strong>S-1 is an orally active anticancer drug known to cause ocular adverse events (AEs), including lacrimal passage obstruction and corneal complications. This study investigated tear concentrations of 5-fluorouracil (5-FU) and tegafur (FT) in patients receiving S-1 treatment and their relationship with ocular AEs.</p><p><strong>Study design: </strong>Multicenter prospective cohort study.</p><p><strong>Methods: </strong>We recruited patients scheduled for S-1 chemotherapy. After initial ophthalmologic examinations at enrollment, serial examinations were performed during the courses of S-1 administration for up to 1 year. Tear samples were collected using Schirmer test strips at the end of the first course of S-1 treatment. 5-FU and FT concentrations were measured using high-performance liquid chromatography.</p><p><strong>Results: </strong>The study cohort comprised 94 patients among whom 38 (40.4%) developed ocular AEs, including 32 (34.0%) corneal AEs, 13 (13.8%) lacrimal AEs, and 7 (7.4%) patients who developed both. The tear FT concentrations in the ocular AE group were significantly higher compared with the group without ocular AEs (3.15 ± 3.09 vs. 1.86 ± 1.56 µg/mL; p = 0.017). There was no difference in tear 5-FU concentration between the 2 groups. The FT concentration in tears in the corneal and lacrimal AE groups was significantly higher than in the group without ocular AEs (p = 0.013 and 0.030, respectively).</p><p><strong>Conclusion: </strong>FT concentration in tears due to oral S-1 therapy is associated with corneal or lacrimal AEs. Measuring FT concentration in tears or plasma may be useful for predicting the onset of ocular AEs.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"447-452"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Fourier harmonic analysis in prostaglandin-associated periorbitopathy patients with blepharoptosis.","authors":"Tatsuya Yunoki, Yuto Uozumi, Naoki Tojo, Mitsuya Otsuka, Atsushi Hayashi","doi":"10.1007/s10384-025-01177-4","DOIUrl":"10.1007/s10384-025-01177-4","url":null,"abstract":"<p><strong>Purpose: </strong>Prostaglandin-associated periorbitopathy (PAP), which causes skin hardening, ptosis, and deepening of the upper eyelid sulcus (DUES), has been suggested to affect corneal shape due to increased eyelid pressure. In this study, we performed a corneal shape analysis using anterior segment optical coherence tomography (AS-OCT) in patients with PAP accompanied by blepharoptosis.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>Fourier harmonic corneal shape analysis using anterior segment OCT was performed in patients with a margin reflex distance-1 (MRD-1) of 2 mm or less (176 eyes of 101 cases). Cases with congenital ptosis, neurogenic ptosis, facial nerve palsy, thyroid eye disease, history of eyelid surgery, vitrectomy, glaucoma tube shunt surgery or filtration surgery were excluded. Patients were divided into two groups based on the presence or absence of prostaglandin analog (PGA) eye drops, and a comparative analysis was conducted.</p><p><strong>Results: </strong>In the comparison between the PGAs group (n=47) and the non-PGAs group (n=129), no significant differences were observed in age, gender, MRD-1, or levator function. However, the PGAs group exhibited significantly larger values for both regular and irregular astigmatism. Additionally, in the PGAs group, when the severity of PAP was classified (grades 0 to 3), there was a correlation between PAP grade and both regular and irregular astigmatism.</p><p><strong>Conclusion: </strong>Patients with PAP who developed ptosis exhibited significant increases in both regular and irregular astigmatism, with a correlation observed between PAP grade and astigmatism. It is suggested that the increased eyelid pressure due to PAP may influence corneal shape.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"360-364"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriologic profile and antimicrobial resistance in infants aged 1 year or younger with congenital nasolacrimal duct obstruction.","authors":"Zhansaya Sultanbayeva, Botagoz Issergepova, Aida Kapanova, Kairat Ruslanuly","doi":"10.1007/s10384-025-01197-0","DOIUrl":"10.1007/s10384-025-01197-0","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to evaluate conjunctival flora and antibiotic susceptibility in infants aged 1 year or younger with congenital nasolacrimal duct obstruction (CNLDO), creating an overall profile of antimicrobial susceptibility.</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Methods: </strong>The analysis was conducted at the Kazakh Eye Research Institute over a period of 6 years, from January 2017 to December 2022. Cultures were grown on various agars for bacterial and fungal analyses, with sensitivity testing via Vitek 2 Compact.</p><p><strong>Results: </strong>We examined 1210 conjunctival cultures from infants with CNLDO, yielding 1212 isolates. Most were gram-positive bacteria (77.15%), with fewer gram-negative bacteria (22.28%) and fungi (0.57%). Among the gram-positive bacteria, Staphylococcus species (61.06%) were predominant, including S epidermidis (17.49%), S aureus (10.73%), and S saprophyticus (9.32%). Enterococcus species (6.52%) and Streptococcus species (6.02%) followed. Among the gram-negative bacteria, Escherichia coli (5.78%) was most prevalent, followed by Pseudomonas species. (4.54%), Enterobacter cloacae (3.71%), and Klebsiella species (3.63%). The majority of the fungi were Candida albicans, accounting for 4 isolates (0.33%). Most of the bacteria showed high sensitivity to moxifloxacin (92.52%), levofloxacin (88.99%), gentamicin (86.74%), vancomycin (86.52%), cefotaxime (85.27%), and ofloxacin (85.62%). High resistance was noted for erythromycin (32.84%), clindamycin (28.13%), and tetracycline (21.65%).</p><p><strong>Conclusion: </strong>In this study, we identified Staphylococcus, Enterococcus, and Streptococcus species and E coli as key CNLDO bacteria and highly responsive to antibiotics like levofloxacin and moxifloxacin. These findings guide effective antibiotic choices for CNLDO treatment, aiding in the prevention of antibiotic resistance.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"442-446"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the retinal age gap and systemic diseases in the Japanese population: the Nagahama study.","authors":"Takuro Kamei, Masahiro Miyake, Keina Sado, Kazuya Morino, Yuki Mori, Yasuharu Tabara, Fumihiko Matsuda, Hiroshi Tamura, Akitaka Tsujikawa","doi":"10.1007/s10384-025-01205-3","DOIUrl":"https://doi.org/10.1007/s10384-025-01205-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the retinal age gap, defined as the difference between deep learning-predicted retinal age and chronological age, as a potential biomarker of systemic health in the Japanese population.</p><p><strong>Study design: </strong>Prospective cohort study.</p><p><strong>Methods: </strong>Data from the Nagahama Study, a large-scale Japanese cohort study, were used. Participants were divided into fine-tuning (n=2,261) and analysis (n=6,070) cohorts based on their visit status across the two periods. The fine-tuning cohort only included individuals without a history of systemic or cardiovascular diseases. A deep learning model, originally released in the Japan Ocular Imaging Registry, was fine-tuned using a fine-tuning cohort to predict retinal age from images. This refined model was then applied to the analysis cohort to calculate retinal age gaps. We conducted cross-sectional and longitudinal analyses to examine the association of these gaps with systemic and cardiovascular diseases.</p><p><strong>Results: </strong>The retinal age-prediction model achieved a mean absolute error of 3.00-3.42 years. Cross-sectional analysis revealed significant associations between the retinal age gap and a history of diabetes (β = 1.08, p < 0.001) and hyperlipidemia (β = -0.67, p < 0.001). Longitudinal analysis showed no significant association between the baseline retinal age gap and disease onset. However, onset of hypertension (β = 0.35, p = 0.049) and hyperlipidemia (β = 0.34, p = 0.035) showed marginal associations with an increase in retinal age gap over time.</p><p><strong>Conclusion: </strong>The retinal age gap is a promising biomarker for systemic health, particularly in relation to diabetes, hypertension, and hyperlipidemia.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binocular visual function in middle-aged patients with unilateral cataract: multifocal versus enhanced monofocal intraocular lens.","authors":"Ken Hayashi, Motoaki Yoshida, Shin-Ichi Manabe, Koichi Yoshimura","doi":"10.1007/s10384-025-01190-7","DOIUrl":"https://doi.org/10.1007/s10384-025-01190-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare binocular visual function of middle-aged patients in the process of presbyopia progression with unilateral cataract who received a trifocal intraocular lens (IOL; Alcon PanOptix^®) with those who received an enhanced monofocal (EM) IOL (Johnson & Johnson Eyehance^®).</p><p><strong>Study design: </strong>Nonrandomized comparative study.</p><p><strong>Methods: </strong>This study enrolled patients in their 40s and 50s with unilateral cataract whose fellow eyes were myopic and the operated eyes were implanted with either a trifocal IOL (n=28, targeting emmetropia) or an EM IOL (n=28, targeting myopia), and patients whose fellow eyes were emmetropic and the operated eyes were implanted with a trifocal IOL (n=25, targeting emmetropia) or an EM IOL (n=23; targeting emmetropia). At 3 months postoperatively, binocular uncorrected and corrected all-distance VA and contrast VA were compared between patients receiving the trifocal and EM IOLs.</p><p><strong>Results: </strong>In the myopia category, mean binocular uncorrected VA from ∞ to 1.0 m was significantly better (P<0.001) and at near distance was significantly worse (P<0.001) in the trifocal group than in the EM group. In the emmetropia category, binocular uncorrected VA from ∞ to 2.0 m and binocular contrast VA at most contrasts were significantly better in the EM group than in the trifocal group (P≤0.043).</p><p><strong>Conclusion: </strong>Trifocal IOLs provide significantly better binocular uncorrected far to intermediate VAs and worse near VA than EM IOLs in patients whose fellow eye is myopic, while EM IOLs provide significantly better far VA and contrast sensitivity in patients whose fellow eye is emmetropic.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of postoperative delirium with visual acuity after ophthalmic surgeries under local anesthesia.","authors":"Yusuke Koga, Koji Kitazawa, Gen Shinozaki, Kengo Yoshii, Jun-Wei B Hughes, Yohei Yamashita, Kentaro Kojima, Morio Ueno, Shigeru Kinoshita, Chie Sotozono","doi":"10.1007/s10384-025-01200-8","DOIUrl":"https://doi.org/10.1007/s10384-025-01200-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the incidence rate and risk factors for postoperative delirium (POD) following ophthalmic surgery under local anesthesia.</p><p><strong>Study design: </strong>A retrospective study METHODS: We retrospectively investigated the incidence rate of POD in 4658 patients who underwent vitrectomy or glaucoma surgery between January 2009 to March 2023 and analyzed the risk factors with multivariate logistic regression compared to non-delirium patients. Risk indices included age, sex, operation time, preoperative best-corrected visual acuity (pre-BCVA), comorbidity of dementia, and the use of sedative or hypnotic drugs.</p><p><strong>Results: </strong>POD developed in 19 out of 4658 patients (0.41%). POD was more prevalent in older patients and those with dementia (P < 0.001 and P < 0.001, respectively). However, sex, longer operation time, the use of sedative or hypnotic drugs were not associated with POD. The low pre-BCVA in either operated eye or fellow eye was more likely observed in patients with POD (P = 0.003 and P = 0.001, respectively). The multivariate logistic regression analysis revealed that age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.00-1.12; P = 0.04), dementia (OR, 34.95; 95% CI, 12.32-99.15; P < 0.001), pre-BCVA in the operated eye (OR, 2.00; 95% CI, 1.13-3.53; P = 0.02) and pre-BCVA in the fellow eye (OR, 1.83; 95% CI, 1.16-2.89; P = 0.01) were significantly associated with developing POD.</p><p><strong>Conclusions: </strong>POD developed following ophthalmic surgery under local anesthesia. Identified risk factors included older age, comorbid dementia and low pre-BCVA.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}