Japanese Journal of Ophthalmology最新文献

{"title":"Comparison of one-year postoperative outcomes between PreserFlo MicroShunt and trabeculectomy in Japanese patients with open angle glaucoma: a retrospective cohort study using propensity score matching.","authors":"Kana Katakami, Mari Sakamoto, Nanami Okuzumi, Yuto Iwaki, Sotaro Mori, Yuko Yamada-Nakanishi, Makoto Nakamura","doi":"10.1007/s10384-026-01374-9","DOIUrl":"10.1007/s10384-026-01374-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare one‑year postoperative outcomes between PreserFlo MicroShunt (PMS) and trabeculectomy (TLE) as primary filtration surgery in Japanese patients with open‑angle glaucoma using propensity score matching.</p><p><strong>Study design: </strong>Retrospective, single‑center observational cohort study.</p><p><strong>Methods: </strong>Patients with open‑angle glaucoma who underwent stand‑alone PMS implantation or TLE at Kobe University Hospital were included. After applying exclusion criteria, 102 eyes in each of 2 groups were matched 1:1 using propensity scores based on age, sex, lens status, glaucoma subtype, preoperative intraocular pressure (IOP), number of glaucoma medications, and best‑corrected visual acuity (BCVA). The primary outcome was IOP at 12 months postoperatively. Secondary outcomes included longitudinal IOP changes, medication use, BCVA, corneal endothelial cell density (ECD), surgical success rates, postoperative complications, and additional surgery. Mixed‑effects models and Kaplan-Meier analyses were performed.</p><p><strong>Results: </strong>At 12 months, mean IOP was significantly lower in the TLE group than in the PMS group (12.3 vs 14.1 mmHg, P = 0.042). Both groups showed significant IOP reduction from baseline. The proportion of medication‑free eyes did not differ between groups. BCVA worsened transiently after surgery and partially recovered but remained worse than baseline at 12 months, with no between‑group differences. ECD decreased modestly in both groups without significant differences. Surgical success rates were comparable across all criteria. Postoperative complications, particularly hypotony‑related events, were more frequent in the TLE group, and persistent hypotony was observed only after TLE.</p><p><strong>Conclusions: </strong>PMS demonstrated a more favorable safety profile with fewer hypotony‑related complications, whereas TLE achieved greater IOP reduction at 12 months. Surgical success rates were comparable. PMS may represent a less invasive option, while TLE may be preferable when maximal IOP lowering is required.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1241-1251"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative risk factors for uncontrolled intraocular pressure after vitrectomy combined with intrascleral fixation of the intraocular lens.","authors":"Masaki Suzue, Susumu Sakimoto, Masanori Kanai, Akihiko Shiraki, Nobuhiko Shiraki, So Goto, Kazuichi Maruyama, Shinichi Usui, Hirokazu Sakaguchi, Kenji Matsushita, Takatoshi Maeno, Kohji Nishida","doi":"10.1007/s10384-026-01376-7","DOIUrl":"10.1007/s10384-026-01376-7","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the factors affecting uncontrolled intraocular pressure (IOP) in eyes with crystalline lens, intraocular lens (IOL) dislocation, or aphakia after pars plana vitrectomy (PPV) combined with the flanged intrascleral IOL fixation technique (ISF) (PPV-ISF), and to examine the risk of high IOP or glaucoma surgery after PPV-ISF.</p><p><strong>Study design: </strong>Retrospective observational cohort study METHODS: This study investigated 100 eyes (97 patients) who underwent PPV-ISF at Osaka University Graduate School of Medicine between July 2020 and June 2022. We evaluated the association of the outcomes of postoperative IOP control with preoperative and postoperative factors. Uncontrolled IOP was defined as an increase in glaucoma eye-drop use or necessity of glaucoma surgery.</p><p><strong>Results: </strong>The mean patient age was 67.9 ± 16.1 years. Among 100 eyes, 13 (13%) were diagnosed with exfoliation syndrome (XFS). Age and XFS were associated with preoperative ocular hypertension (P = .03, P = .005). After PPV-ISF, the use of eye drops was increased in 25 patients, and 10 eyes (10%) underwent glaucoma surgery. In the multiple logistic regression analysis, the odds ratios for uncontrolled IOP in XFS, previous glaucoma surgery, and previous vitrectomy surgery were 5.67 (P = .001), 8.98 (P = .004), and 1.43 (P = .508), respectively.</p><p><strong>Conclusion: </strong>XFS and history of glaucoma surgery are associated with poor IOP control after PPV-ISF surgery.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1073-1078"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction in extraocular muscle and orbital fat volumes after teprotumumab treatment in Japanese patients with thyroid eye disease: an exploratory magnetic resonance imaging analysis from the OPTIC-J trial.","authors":"Ai Kozaki, Yasuhiro Takahashi, Yuji Tajiri, Zhenxun Wang, Tomoko Hayashida, Ada Kumar, Yuji Hiromatsu, Masashi Mimura","doi":"10.1007/s10384-026-01372-x","DOIUrl":"10.1007/s10384-026-01372-x","url":null,"abstract":"<p><strong>Purpose: </strong>This substudy of the OPTIC-J trial analyzed magnetic resonance imaging (MRI) scans from a subset of Japanese patients to examine changes in orbital tissues after teprotumumab treatment vs placebo for active thyroid eye disease (TED).</p><p><strong>Study design: </strong>Post hoc exploratory.</p><p><strong>Methods: </strong>Volumes and inflammation/edema of extraocular muscles (EOMs) and orbital fat were measured before and after 24 weeks of teprotumumab treatment or placebo using MRI in patients enrolled at four of the 16 trial sites. Inflammation/edema in EOM and orbital fat were evaluated using the signal intensity ratio, based on T2 intensity in the cerebral white matter, and an ordinal grading scale (0-3), respectively. Key clinical outcomes included proptosis, diplopia, and clinical activity score (CAS).</p><p><strong>Results: </strong>Mean (%) changes in total EOM and orbital fat volumes in study eyes treated with teprotumumab (n = 6) and placebo (n = 8) were -1,022 mm³ (-31%; P = 0.007) and -348 mm³ (-11%; P = 0.039), and -771 mm³ (-6%; P = 0.120) and 418 mm³ (4%; P = 0.084), respectively. Reductions were significantly greater with teprotumumab vs placebo (EOM, P = 0.021; fat, P = 0.016). Mean (%) changes in total EOM and orbital fat inflammation/edema grading of study eyes treated with teprotumumab were -1.82 (-31%; P = 0.005) and -1 (P = 0.031), respectively. Patients administered teprotumumab exhibited improvements in proptosis (83%), diplopia (67%), and resolution of activity determined by CAS (50%).</p><p><strong>Conclusion: </strong>In this OPTIC-J trial substudy, reductions in orbital soft tissue volumes and inflammation/edema were observed with MRI after teprotumumab treatment vs placebo; corresponding improvements in TED clinical outcomes were also observed.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1089-1098"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient increase in flicker ERG amplitude preceding OCT-detected macular thickening in eyes with acute anterior uveitis.","authors":"Kumiko Kato, Keitaro Mizumoto, Ryunosuke Nagashima, Mayumi Momose, Yuzen Kashima, Sumine Mori, Hisashi Matsubara, Mineo Kondo","doi":"10.1007/s10384-026-01383-8","DOIUrl":"10.1007/s10384-026-01383-8","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the changes in amplitude of the flicker electroretinograms (ERGs) and central macular thickness (CMT) during the acute phase of acute anterior uveitis (AAU).</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>Flicker ERGs (RETeval) and optical coherence tomographic (OCT) images were recorded from the affected and fellow eyes at multiple examination times. The outcomes are expressed as a ratio of the affected-to-fellow eyes (×100). The time courses were modeled by polynomial regression (degrees 1-4) with model selection based on R², Akaike, or Bayesian information criteria (AIC, BIC), and the P values. The peak timing and uncertainty were estimated by patient-level cluster bootstrap resampling (B=2000).</p><p><strong>Results: </strong>Eight eyes from eight patients (4 men, 4 women; mean age 48.8±15.8 years) underwent 3.3±1.0 paired ERG/OCT assessments. The ratio of the amplitudes of the two eyes had a significant nonlinear time course, and a 4th-degree model was best supported (R²=0.411, P=0.021). Bootstrap estimated an amplitude peak at 11.8 days (median 11.9; 95% CI 10.2-19.0) with a peak value of 134.6%. The ratios of the implicit times were not significantly associated with the disease duration. The CMT ratio had a significant nonlinear time course and a 2nd-degree model was best supported (R²=0.358, P=0.006). Bootstrap analyses estimated a CMT peak at 35.4 days (median 35.1; 95% CI 29.2-48.4) with a peak value of 108.6%.</p><p><strong>Conclusions: </strong>The flicker ERG amplitudes increase transiently around two weeks after the onset of AAU and subsequent macular thickening in the OCT images. These findings suggest that flicker ERGs may serve as an early functional retinal marker of subclinical posterior segment inflammation in eyes with AAU.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1252-1259"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a machine learning model using systemic and ophthalmic parameters to detect sleep-disordered breathing in glaucoma patients.","authors":"Naoki Kiyota, Mai Yamazaki, Noriko Himori, Takahiro Ninomiya, Koki Osada, Takeshi Yabana, Shigeto Maekawa, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Toru Nakazawa","doi":"10.1007/s10384-026-01386-5","DOIUrl":"10.1007/s10384-026-01386-5","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and validate a machine-learning model using systemic and ophthalmic parameters that predicts sleep-disordered breathing (SDB) in patients with open-angle glaucoma (OAG).</p><p><strong>Study design: </strong>Retrospective cross-sectional study METHODS: We analyzed 513 patients with OAG (955 eyes) treated at Seiryo Eye Clinic. All the participants underwent comprehensive ophthalmic examinations, including Humphrey visual field (HVF) testing, and home sleep apnea testing (HSAT) to obtain the 4% oxygen desaturation index (ODI). SDB was operationally defined as ODI-SAS, ie, sleep apnea syndrome (SAS) defined by HSAT-derived 4% ODI ≥15 events per hour. Sixteen algorithms were trained to predict ODI-SAS; model performance was assessed by the area under the receiver operating characteristic curve (ROC-AUC), precision, recall, the F1 score, and the Matthews correlation coefficient (MCC).</p><p><strong>Results: </strong>One hundred fifty-eight patients (30.80%) met the ODI-SAS criterion. ODI-SAS status was associated with a history of hypertension, higher body mass index, family-reported apnea, shorter axial length, fewer antiglaucoma medications, and worse inferocentral total deviation on HVF (all P < 0.05), but not with self-awareness of snoring or previous SAS diagnosis. A gradient-boosted decision-tree model (CatBoost) achieved the best performance (ROC-AUC 0.86), with precision 0.692, recall 0.711, F1 score 0.701, and MCC 0.543.</p><p><strong>Conclusion: </strong>Machine-learning models can predict ODI-SAS in glaucoma using systemic risk factors together with ophthalmic features, including inferocentral visual-field defects. Such models may help identify OAG patients who warrant formal sleep evaluation.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1218-1228"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Tomographic and biomechanical refractive findings in ocular pediatric allergy.","authors":"Wimolwan Tangpagasit, Suntaree Thitiwichienlert, Danaya Hongsuraphan","doi":"10.1007/s10384-026-01409-1","DOIUrl":"10.1007/s10384-026-01409-1","url":null,"abstract":"","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1296"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Branch retinal vein occlusion in Leber hereditary optic neuropathy with onset at age 50 years or older: frequency and clinical characteristics.","authors":"Yasuyuki Takai, Akiko Yamagami, Kenji Inoue, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1007/s10384-026-01364-x","DOIUrl":"10.1007/s10384-026-01364-x","url":null,"abstract":"<p><strong>Purpose: </strong>To describe branch retinal vein occlusion (BRVO) observed in patients with Leber hereditary optic neuropathy (LHON) with onset at age ≥50 years and to explore whether BRVO prevalence may be higher than age- and sex-matched general population estimates.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>We reviewed 187 genetically confirmed LHON patients seen at a single center (1990-2024) and analyzed 39 patients with LHON onset at age ≥50 years. We summarized fundus findings, management, and longitudinal visual function. We also performed indirect standardization using age- and sex-specific BRVO point prevalence from the Hisayama Study to calculate the standardized prevalence ratio (SPR) for BRVO diagnosed before LHON onset; a sensitivity analysis used an ever-BRVO definition that also included post-onset cases.</p><p><strong>Results: </strong>Four patients had BRVO. Three cases were diagnosed before LHON onset (SPR 3.88; 95% CI 0.80-11.34), and inclusion of one post-onset case increased the SPR to 5.17 (95% CI 1.41-13.25). Macular atrophy was present in two patients. All patients underwent laser photocoagulation and none received intravitreal anti-vascular endothelial growth factor (VEGF) therapy. Longitudinal visual function generally showed persistent central visual field loss consistent with LHON, with some BRVO-affected eyes demonstrating additional nasal or inferonasal components at follow-up.</p><p><strong>Conclusion: </strong>In this older-onset LHON cohort, BRVO was observed in four patients and detailed case-level characteristics are presented. The indirect standardized comparison suggests a tendency toward higher standardized BRVO prevalence; however, this prevalence-based analysis is not adjusted for vascular risk profiles and should be interpreted as hypothesis-generating.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1174-1181"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 survey of the frequency of fixed-combination eye drop use by patients with glaucoma at multiple private practices in Japan.","authors":"Kenji Inoue, Minako Shiokawa, Shiho Kunimatsu-Sanuki, Goji Tomita, Kyoko Ishida","doi":"10.1007/s10384-026-01368-7","DOIUrl":"10.1007/s10384-026-01368-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the current (2024) use of fixed-combination eye drops in Japanese patients with glaucoma.</p><p><strong>Study design: </strong>Cross-sectional survey.</p><p><strong>Methods: </strong>The survey included 6323 outpatients (6323 eyes) with glaucoma or ocular hypertension at 82 private practices from March 10 to 16, 2024. The use of fixed-combination eye drops, including prostaglandin F (FP) receptor agonist/β-blocker (FP/β), carbonic anhydrase inhibitor/β-blocker (CAI/β), α2-adrenergic agonist/β-blocker (α2/β), α2-adrenergic agonist/carbonic anhydrase inhibitor (α2/CAI), and α2-adrenergic agonist/Rho-associated protein kinase (α2/ROCK), was analyzed, stratified by the number of medications used. The results were compared with those of a 2020 survey via χ² tests.</p><p><strong>Results: </strong>FP/β, CAI/β, α2/β, α2/CAI, and α2/ROCK were used by respectively 56.4%, 8.0%, 2.2%, 2.9%, and 0.6% of 2-medication users; 42.5%, 30.2%, 3.2%, 11.2%, and 4.1% of 3-medication users; and 56.6%, 32.1%, 1.7%, 45.5%, and 14.4% of ≥4-medication users. FP/β were the most commonly used in all groups. Compared with the previous survey, the use of FP/β increased significantly in all groups, while that of CAI/β decreased significantly. Among four-medication users, 228 patients (44.4%) used two types of fixed-combination eye drops. In this group, FP/β + α2/CAI (186 cases) was the most common. Among five-medication users, 186 patients (69.9%) used two types of fixed-combination eye drops. In this group, FP/β + α2/CAI + one additional drug (131 cases) was the most common.</p><p><strong>Conclusion: </strong>Fixed-combination eye drops were used in >70% of patients using 2 medications and >90% of patients using ≥3 medications. Over time, the use of FP/β increased, while the use of CAI/β decreased.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1190-1200"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary corneal amyloidosis in a patient with Meesmann corneal dystrophy.","authors":"Jini Qiu, Yue Li, Rongrong Cai, Chaoran Zhang","doi":"10.1007/s10384-026-01365-w","DOIUrl":"10.1007/s10384-026-01365-w","url":null,"abstract":"<p><strong>Background: </strong>Meesmann corneal dystrophy (MCD) is a rare autosomal dominant corneal disorder characterized by recurrent epithelial erosions. While secondary corneal amyloidosis (SCA) is well-documented in chronic inflammatory disorders, its occurrence in MCD has not been previously described.</p><p><strong>Case: </strong>Here we first report a case of concurrent MCA and SCA, the diagnosis was confirmed through clinical evaluation, Anterior segment optical coherence tomography, in vivo laser confocal microscopy, and histopathological examination. Genetic testing identified a novel KRT12 mutation (c.1292G>C, p.R431P) in both the patient and her affected father, though the father exhibited no signs of SCA.</p><p><strong>Conclusions: </strong>SCA may develop as a rare complication in patients with long-standing MCD, potentially complicating the diagnosis.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1059-1065"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-encircling continuous suture technique for complete cyclodialysis: a consecutive case series.","authors":"Takashi Ueta, Rei Sakata, Megumi Honjo","doi":"10.1007/s10384-026-01367-8","DOIUrl":"10.1007/s10384-026-01367-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and efficacy of a novel double-encircling continuous suture technique for the surgical repair of complete (360°) cyclodialysis.</p><p><strong>Study design: </strong>Retrospective interventional case series.</p><p><strong>Methods: </strong>Medical records of seven consecutive eyes from seven patients with complete cyclodialysis treated at the University of Tokyo Hospital between 2022 and 2025 were retrospectively reviewed. The extent of cyclodialysis and postoperative anatomical outcomes were assessed using anterior segment optical coherence tomography (OCT). Intraocular pressure (IOP) and best-corrected visual acuity (BCVA) were recorded both pre- and post-operatively. The surgical technique consisted of placing two laps of encircling continuous 10-0 polypropylene sutures at 3-4 mm and 2-3 mm posterior to the limbus. In phakic eyes, phacoemulsification with intraocular lens and capsular tension ring implantation were performed concurrently.</p><p><strong>Results: </strong>Four men and three women with a mean age of 43.6 ± 25.4 years were included. Cyclodialysis resulted from blunt trauma (n = 3) or surgical complications (n = 4). Preoperative IOP ranged from 2 to 8 mmHg, and hypotonic maculopathy was observed in all cases. Postoperatively, anatomical reattachment of the ciliary body and resolution of hypotony were achieved in six of seven eyes (85.7%). All eyes demonstrated improved BCVA, though the improvement depended on comorbid conditions such as glaucoma, pathologic myopia, and bullous keratopathy. IOP transiently elevated postoperatively, and additional glaucoma surgery was necessary in two cases with a history of glaucoma.</p><p><strong>Conclusion: </strong>Reproducible safety and efficacy were confirmed for the double-encircling continuous suture technique in repairing complete cyclodialysis, yielding anatomical success and functional improvement.</p>","PeriodicalId":14563,"journal":{"name":"Japanese Journal of Ophthalmology","volume":" ","pages":"1201-1207"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}