Evaluating efficacy of 0.125% atropine using a myopia progression machine learning model.

IF 2.1 3区 医学 Q2 OPHTHALMOLOGY
Chang Yoon Han, Sa Ra Kim, Dae Hee Kim
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引用次数: 0

Abstract

Purpose: To investigate the usefulness of a machine learning (ML) model that can predict the natural course of childhood myopia in evaluation of the inhibitory effects of 0.125% atropine on the progression of childhood myopia.

Study design: Retrospective, cohort study.

Methods: A retrospective analysis was conducted on children treated daily with 0.125% atropine eye drops. The children were classified into 6-, 12-, 18-, 24-, and 30-month group based on the treatment duration. Spherical equivalents (SE) at the last treatment time point were compared with the pretreatment and ML-predicted SE. The myopia suppression rate due to treatment was calculated based on the first- and ML-predicted SE.

Results: A total of 771 eyes (402 boys and 369 girls) from 397 children were included. The participants' mean age was 8.0 ± 1.5 years. The first SE of -2.87 ± 1.67 diopters (D), treatment led to a mean SE of -3.44 ± 1.90 D, showing a significant reduction in myopia progression compared to the ML model's prediction of -4.12 ± 1.75 D. Except for the 6-month group, the last SE was statistically significantly less myopic than the predicted SE, indicating that treatment suppressed progression compared to the natural course. The mean myopia suppression rate was 53.5%, with definite differences between the groups.

Conclusion: Treatment with 0.125% atropine may suppress myopia progression in children compared with the ML child myopia prediction model. The application of a machine learning model to predict myopia progression may assist in evaluating the efficacy of 0.125% atropine treatment.

使用近视进展机器学习模型评估0.125%阿托品的疗效。
目的:探讨预测儿童近视自然发展过程的机器学习(ML)模型在评价0.125%阿托品对儿童近视发展的抑制作用中的实用性。研究设计:回顾性队列研究。方法:对每日使用0.125%阿托品滴眼液的患儿进行回顾性分析。根据治疗时间分为6个月、12个月、18个月、24个月和30个月组。最后处理时间点的球形当量(SE)与预处理和ml预测的SE进行了比较。根据第一次和ml预测的SE计算治疗后的近视抑制率。结果:共纳入397例儿童771只眼(男生402只,女生369只)。参与者平均年龄8.0±1.5岁。治疗后的第一次SE为-2.87±1.67屈光度(D),平均SE为-3.44±1.90 D,与ML模型预测的-4.12±1.75 D相比,近视进展明显减少。除6个月组外,最后一次SE的近视程度明显低于预测SE,表明治疗抑制了进展,与自然过程相比。平均近视抑制率为53.5%,组间差异有统计学意义。结论:与ML儿童近视预测模型相比,0.125%阿托品治疗可抑制儿童近视进展。应用机器学习模型预测近视进展可能有助于评估0.125%阿托品治疗的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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