Macular hole following vitrectomy for rhegmatogenous retinal detachment: a comparative study of epiretinal membrane-related factors.

IF 1.9 3区医学 Q2 OPHTHALMOLOGY

Japanese Journal of Ophthalmology Pub Date : 2025-10-23 DOI:10.1007/s10384-025-01291-3

Jong-Uk Lee, Seung Jun Oh, Jooyoung Huh, Young Joon Jo

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引用次数: 0

Abstract

Purpose: To investigate macular hole (MH) development after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) and identify epiretinal membrane (ERM)-related factors contributing to MH formation.

Study design: Retrospective case series.

Methods: A retrospective analysis was performed on patients who underwent vitrectomy for RRD between January 2008 and December 2022 and subsequently developed ERM or MH requiring secondary surgery. Patients were categorized into two groups: ERM with MH progression (MH group, n=15) and ERM only (ERM group, n=25). Medical records were reviewed to identify potential risk factors including patient demographics, preoperative clinical findings, central macular thickness (CMT), and ERM characteristics using optical coherence tomography (OCT).

Results: CMT measured after ERM occurrence was significantly lower in the MH group (299.23 ± 69.56 μm) compared to the ERM group (445.8 ± 118.34 μm, p < 0.01). The MH group predominantly showed flat foveal contour, whereas the ERM group exhibited significant loss of foveal depression (p < 0.01). Epiretinal proliferation was observed in all MH group cases (100%) versus 24% in the ERM group (p < 0.01). The foveal crack sign was present in 73.3% of MH group cases but absent in the ERM group (p < 0.001).

Conclusion: Following successful RRD surgery, the occurrence of MH is a possiblity associated with specific OCT biomarkers. Our findings suggest that centrifugal tangential traction, distinct from conventional centripetal ERM formation, contributes to MH development after RRD repair.

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玻璃体切除术后黄斑裂孔治疗孔源性视网膜脱离：视网膜前膜相关因素的比较研究。

目的：探讨黄斑裂孔（MH）在黄斑裂孔玻璃体切除术（PPV）治疗孔源性视网膜脱离（RRD）后的形成及视网膜前膜（ERM）相关因素。研究设计:回顾性病例系列。方法：回顾性分析2008年1月至2022年12月期间因RRD接受玻璃体切除术并随后发生ERM或MH需要二次手术的患者。患者分为两组：合并MH进展的ERM组（MH组，n=15）和仅ERM组（ERM组，n=25）。研究人员回顾了医疗记录，以确定潜在的危险因素，包括患者人口统计学、术前临床表现、中央黄斑厚度（CMT）和光学相干断层扫描（OCT）的ERM特征。结果：ERM发生后，MH组CMT（299.23±69.56 μm）明显低于ERM组（445.8±118.34 μm, p < 0.01）。MH组大鼠中央凹轮廓明显平坦，ERM组大鼠中央凹轮廓明显消失（p < 0.01）。MH组患者视网膜上皮增生发生率为100%，ERM组为24% （p < 0.01）。73.3%的MH组患者出现中央凹裂纹征象，而ERM组患者无此征象（p < 0.001）。结论：RRD手术成功后，MH的发生可能与特定的OCT生物标志物有关。我们的研究结果表明，与传统的向心ERM形成不同，离心切向牵引有助于RRD修复后MH的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Ophthalmology 医学-眼科学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.