Clinical presentation and prognostic factors of eyelid sebaceous carcinoma.

IF 1.9 3区医学 Q2 OPHTHALMOLOGY

Japanese Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-05-25 DOI:10.1007/s10384-025-01187-2

Yukiko Aihara, Masachika Ikegami, Yoshiyuki Suehara, Takane Watanabe, Seiichi Yoshimoto, Taisuke Mori, Hiroyuki Mano, Shinji Kohsaka, Shigenobu Suzuki

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引用次数: 0

Abstract

Purpose: To clarify the demographics, clinical features, outcomes, and prognostic factors of Japanese patients with eyelid sebaceous carcinoma.

Study design: Retrospective study.

Methods: Fifty-two patients with eyelid sebaceous carcinoma diagnosed histopathologically at the National Cancer Center Hospital in Japan between 2013 and 2023 were reviewed and their outcomes were examined.

Results: There were 21 men and 31 women. The median age at diagnosis was 73 (range 39-95) years old. The tumor was located in the upper eyelid in 33 patients (63%), in the lower eyelid in 16 patients (31%), and in both eyelids in 3 patients (6%). The initial curative treatment included surgical resection with or without eyelid reconstruction in 41 cases (79%), orbital exenteration in 4 cases (8%), and radiation therapy in 7 cases (13%). Two- and five-year adjusted survival rates were 97.4% and 93.7%, respectively. Local recurrence occurred in 15 cases (29%). Lymph node metastasis was confirmed in 13 cases (27%), distant metastasis in 5 cases (10%), and 3 patients (6%) died of lung metastasis. T2b or more advanced T stage was associated with a risk of shorter overall survival (HR = 5.3, 95% CI = 1.2-23, p = 0.024) compared with T2a or earlier stage, as well as lymph node metastasis (HR = 82, 95% CI = 2.6-2.6e+03, p = 0.013). A positive surgical margin increased the risk of local recurrence (HR = 37, 95% CI = 5.9- 235, p = 0.00012).

Conclusion: Proper diagnosis and margin-free resection are necessary before eyelid sebaceous carcinoma can further develop.

查看原文本刊更多论文

眼睑皮脂腺癌的临床表现及预后因素分析。

目的：了解日本眼睑皮脂腺癌患者的人口学特征、临床特征、预后及预后因素。研究设计：回顾性研究。方法：回顾性分析2013 - 2023年在日本国立癌症中心医院经组织病理学诊断的52例眼睑皮脂腺癌患者的预后。结果：男性21例，女性31例。诊断时的中位年龄为73岁（39-95岁）。肿瘤位于上眼睑33例（63%），位于下眼睑16例（31%），位于双眼睑3例（6%）。初始治疗包括手术切除伴或不伴眼睑重建41例（79%），眼眶摘除4例（8%），放射治疗7例（13%）。2年和5年调整生存率分别为97.4%和93.7%。局部复发15例（29%）。确诊淋巴结转移13例（27%），远处转移5例（10%），死于肺转移3例（6%）。与T2a或更早期相比，T2b或更晚期的T期与更短的总生存期（HR = 5.3, 95% CI = 1.2-23, p = 0.024）以及淋巴结转移（HR = 82, 95% CI = 2.6-2.6e+03, p = 0.013）相关。手术切缘阳性增加了局部复发的风险（HR = 37, 95% CI = 5.9- 235, p = 0.00012）。结论：眼睑皮脂腺癌的进一步发展需要正确的诊断和无切缘切除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Ophthalmology 医学-眼科学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.