Two-year outcomes of treat-and-extend regimen with intravitreal faricimab for treatment-naïve neovascular age-related macular degeneration.

IF 2.1 3区 医学 Q2 OPHTHALMOLOGY
Junki Hoshino, Hidetaka Matsumoto, Saki Numaga, Kosuke Nakamura, Hideo Akiyama
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引用次数: 0

Abstract

Purpose: We previously reported 1-year outcomes of a treat-and-extend (TAE) regimen with intravitreal faricimab (IVF) for treatment-naïve neovascular age-related macular degeneration (nAMD). Herein, we evaluated the second-year results of this TAE regimen with IVF in eyes completing the first-year treatment.

Study design: Retrospective, interventional case series.

Methods: We retrospectively studied 30 eyes with treatment-naïve nAMD that had completed the initial year of treatment, assessing best-corrected visual acuity (BCVA), foveal thickness (FT), central choroidal thickness (CCT), total number of injections over 2 years, and intended injection interval at the last visit.

Results: Twenty-five eyes completed the 2-year IVF treatment. There was no significant difference between pre-treatment and 2 years post-treatment BCVA. FT and CCT both showed significant reductions, maintained during the 2-year study period. The total number of injections was 10.1 ± 1.2 over the 2 years. The intended injection interval at the last visit was 13.0 ± 3.4 weeks. Of 5 eyes not completing 2 years of IVF treatment, 4 were switched to other anti-vascular endothelial growth factor (VEGF) agents due to persistent fluids despite IVF at 8-week intervals. In the remaining eye, IVF treatment was discontinued due to suspected faricimab-related intraocular inflammation.

Conclusions: The TAE regimen with IVF for treatment-naïve nAMD was effective during a 2-year period for improving exudative changes and maintaining visual acuity. Although IVF was found to be a relatively safe treatment for nAMD, there were cases requiring a switch to other anti-VEGF agents due to inadequate fluid control effect.

玻璃体内法利西单抗治疗treatment-naïve新生血管性年龄相关性黄斑变性的两年结果
目的:我们之前报道了使用玻璃体内法利西单抗(IVF)治疗treatment-naïve新生血管性年龄相关性黄斑变性(nAMD)的1年治疗延长(TAE)方案的结果。在此,我们评估了该TAE方案的第二年结果,并在完成第一年治疗的眼睛中进行体外受精。研究设计:回顾性、干预性病例系列。方法:我们回顾性研究30只完成第一年治疗的treatment-naïve nAMD眼,评估最佳矫正视力(BCVA)、中央凹厚度(FT)、中央脉络膜厚度(CCT)、2年内的总注射次数和最后一次就诊时的预期注射间隔。结果:25只眼完成2年IVF治疗。治疗前与治疗后2年BCVA无显著差异。在2年的研究期间,FT和CCT都显示出显著的下降。2年总注射次数为10.1±1.2次。末次访视预期注射间隔为13.0±3.4周。在5只未完成2年试管婴儿治疗的眼睛中,4只由于试管婴儿期间持续积液而切换到其他抗血管内皮生长因子(VEGF)药物。在剩余的眼睛中,由于怀疑法利西马相关的眼内炎症,IVF治疗被停止。结论:TAE方案联合IVF治疗treatment-naïve nAMD在2年期间内对改善渗出变化和维持视力有效。虽然体外受精被认为是一种相对安全的治疗nAMD的方法,但由于液体控制效果不足,有些病例需要改用其他抗vegf药物。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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