韩国视觉雪综合征的神经眼科表现。

IF 2.1 3区 医学 Q2 OPHTHALMOLOGY
Ha Eun Park, Hyun Jin Shin, Andrew G Lee
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引用次数: 0

摘要

目的:探讨韩国人群视觉雪综合征(VSS)的神经眼科特征、潜在诱因和治疗反应。研究设计:回顾性病例系列。方法:回顾性分析某三级医院2021年3月至2024年2月诊断为VSS的患者资料。对视觉和非视觉症状、导致VSS的自我报告事件以及医学和精神合并症的数据进行了图表回顾。评估了MRI和18F-FDG PET的神经影像学结果,以及对药物干预和过滤眼镜的治疗反应。结果:男性27例,女性36例,平均年龄27±11岁(mean±SD),发病年龄22.4±11岁。常见症状包括飞蚊症、厌食、焦虑和抑郁。14名参与者将VSS的发病归因于特定的眼科事件(例如屈光手术或强光眼科检查)。18F-FDG PET扫描显示视觉皮层高代谢(81.8%),MRI未见明显异常。拉莫三嗪(18.9%)、阿普唑仑(20%)和滤光眼镜(32.1%)在降低VSS强度方面效果一般。结论:韩国VSS患者表现出与西方人群相似的临床特征、神经影像学表现和治疗反应。眼科手术,如屈光手术和强光检查,可能是易感人群的潜在诱因。尽管包括18F-FDG PET在内的功能成像可能有助于评估VSS,但需要进一步的健康对照研究和定量分析来验证其诊断价值。鉴于治疗效果一般,结合药物干预、过滤眼镜和心理支持的多学科方法对优化结果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuro-ophthalmic findings of Visual Snow Syndrome in Korea.

Purpose: To investigate the neuro-ophthalmologic characteristics, potential triggers, and treatment responses of visual snow syndrome (VSS) in a Korean population.

Study design: Retrospective case series.

Methods: We retrospectively reviewed the data of patients diagnosed with VSS at a tertiary hospital from March 2021 to February 2024. Data on visual and nonvisual symptoms, self-reported events that caused VSS, and medical and psychiatric comorbidities were chart-reviewed. Neuroimaging findings from MRI and 18F-FDG PET were evaluated, along with treatment responses to pharmacological interventions and filter glasses.

Results: The sample comprised 27 men and 36 women, with a mean age of 27±11 years (mean±SD) and onset age of 22.4±11 years. Common symptoms included floaters, palinopsia, anxiety, and depression. Fourteen participants attributed VSS onset to specific ophthalmic events (e.g. refractive surgery or ophthalmic examinations with bright-light). 18F-FDG PET scans showed hypermetabolism in the visual cortices (81.8%), with no significant MRI abnormalities. Lamotrigine (18.9%), alprazolam (20%), and filter glasses (32.1%) showed modest efficacy in reducing the intensity of VSS.

Conclusion: Korean patients with VSS exhibited clinical features, neuroimaging findings, and treatment responses similar to those reported in Western populations. Ophthalmic procedures, such as refractive surgery and bright-light examinations, may act as potential triggers in susceptible individuals. Although functional imaging, including 18F-FDG PET, may be useful for evaluating VSS, further studies with healthy controls and quantitative analyses are needed to validate its diagnostic value. Given the modest treatment efficacy, a multidisciplinary approach combining pharmacological intervention, filter glasses, and psychological support is essential to optimize outcomes.

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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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