Loading phase outcomes of intravitreal aflibercept 8 mg for treatment-naïve neovascular age-related macular degeneration.

IF 1.9 3区 医学 Q2 OPHTHALMOLOGY
Hidetaka Matsumoto, Junki Hoshino, Saki Numaga, Yosuke Asatori, Hideo Akiyama
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引用次数: 0

Abstract

Purpose: To investigate the efficacy and safety of loading phase treatment with 3 monthly intravitreal injections of aflibercept 8 mg for neovascular age-related macular degeneration (nAMD).

Study design: Retrospective, interventional case series.

Methods: We retrospectively analyzed 83 consecutive eyes of 80 patients with treatment-naïve nAMD who received 3 monthly injections of aflibercept 8 mg as a loading phase treatment. Best-corrected visual acuity (BCVA), foveal thickness, central choroidal thickness (CCT), and dry macula achievement were all assessed every 4 weeks. Moreover, polypoidal lesion regression was evaluated after the loading phase.

Results: Seventy eyes (84.3%) of 67 patients completed the 3 monthly injections of aflibercept 8 mg. In these cases, BCVA was 0.33±0.45 at baseline and showed significant improvement to 0.22±0.38 at week 12 (P<0.01). Foveal thickness was 313±135µm at baseline, decreasing significantly to 171±76µm at week 12 (P<0.01). CCT was 193±98µm at baseline, decreasing significantly to 160±85µm at week 12 (P<0.01). Dry macula had been achieved in 58 (82.9%) of 70 eyes at week 12. Indocyanine green angiography after the loading phase revealed complete polypoidal lesion regression in 16 of 22 eyes (72.7%) with polypoidal lesions. Among the 13 eyes (15.7%) not completing the loading phase treatment, 9 (10.8%) developed non-infectious intraocular inflammation (IOI) associated with retinal vasculitis and aflibercept 8 mg administration was thus discontinued.

Conclusions: Loading phase treatment with intravitreal aflibercept 8 mg appears to be effective for improving visual acuity and ameliorating exudative changes in eyes with nAMD. However, careful monitoring is required due to the potential development of IOI associated with retinal vasculitis.

8 mg玻璃体腔内注射阿布西普治疗treatment-naïve新生血管性老年性黄斑变性的负荷期结果。
目的:探讨负荷期3个月玻璃体内注射阿布西普8mg治疗新生血管性年龄相关性黄斑变性(nAMD)的疗效和安全性。研究设计:回顾性、干预性病例系列。方法:我们回顾性分析了80例treatment-naïve nAMD患者的83个连续眼,这些患者接受3个月注射阿伯西普8 mg作为加载期治疗。最佳矫正视力(BCVA)、中央凹厚度、中央脉络膜厚度(CCT)和干黄斑成就均每4周进行一次评估。此外,在加载阶段后评估息肉样病变的消退。结果:67例患者中70只眼(84.3%)完成了3个月注射阿伯西贝8mg。在这些病例中,BCVA在基线时为0.33±0.45,在第12周时显着改善至0.22±0.38。结论:加载期玻璃体内注射阿布西贝8mg似乎对改善视力和改善nAMD眼睛的渗出变化有效。然而,由于与视网膜血管炎相关的潜在IOI发展,需要仔细监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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