Irish Journal of Medical Science最新文献

{"title":"A long-term experience of day-case pelvic osteotomy for developmental dysplasia of the hip.","authors":"Dave M Moore, Catherine Howells, Olga Gallagher, David P Moore, Pat O'Toole","doi":"10.1007/s11845-025-03963-y","DOIUrl":"10.1007/s11845-025-03963-y","url":null,"abstract":"<p><strong>Objective: </strong>Developmental hip dysplasia has an incidence of 6.73 per 1000 live births and leads to a significant number of orthopaedic referrals annually. This high demand has encouraged the drive to optimize the efficiency of service provision in the paediatric orthopaedic setting. Here we describe our long-term experience with a novel day-case pelvic osteotomy initiative. We also describe any potential complications one can expect when performing day-case pelvic osteotomies.</p><p><strong>Methods: </strong>This was a non-randomized prospective cohort study conducted to compare conventional in-patient pelvic osteotomies with day-case osteotomies performed between January 2017 and November 2023. All surgeries took place at an urban tertiary national referral centre by four paediatric orthopaedic surgeons with a specialist interest in DDH.</p><p><strong>Results: </strong>164 Salter and Pemberton osteotomies were performed of which 115 met the day-case criteria. Based on the HSE 'Specialty Costing Report' and 'Annual Report and Financial Statements', the total discharge cost for patients undergoing an in-patient osteotomy was €6619 in contrast to €2670 per day-case patient. For the 110 day-cases, the cost to treat amounted to €293,700; hence, there was a total saving of €434,390 made by the hospital for the 110 day-cases performed. This amounts to €3949 saved for every day-case.</p><p><strong>Conclusion: </strong>Review at 7 years has demonstrated that day-case pelvic osteotomy surgery for DDH remains a safe and cost-effective initiative that significantly reduces the demand on in-patient hospital bed resources.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"963-967"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage migration inhibitory factor (rs755622) gene polymorphism in vitiligo.","authors":"Doaa Falih Hadi, Abdel-Aziz Ibrahim El-Taweel, Amany Ibrahim Mustafa, Ola Samir El-Shimi, Mahmoud A Rageh","doi":"10.1007/s11845-025-03966-9","DOIUrl":"10.1007/s11845-025-03966-9","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a cutaneous disease caused by the destruction of functioning melanocytes. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity.</p><p><strong>Aims: </strong>We tried to investigate the association between MIF (rs755622) gene polymorphism and vitiligo susceptibility and its relationship to severity and clinical types of the disease.</p><p><strong>Methods: </strong>Fifty patients with vitiligo and 50 healthy controls were included. Determination of MIF gene (rs755622) single nucleotide polymorphism was conducted using polymerase chain reaction (PCR).</p><p><strong>Results: </strong>There were 18 males and 32 females who had vitiligo, together with 50 control participants of matched age and gender. Taking GG genotype and G allele as references, MIF GC, CC, (GC + CC) genotypes, and C allele demonstrated a substantially higher occurrence in all patients when compared to controls, with a higher risk of developing vitiligo within healthy control subjects.</p><p><strong>Conclusions: </strong>To the best of our knowledge, this is the third study worldwide and the first from Egypt to investigate the association between MIF gene polymorphism (rs755622) with vitiligo susceptibility and severity, and it showed that MIF gene polymorphism (rs755622) may be considered a risk factor for vitiligo susceptibility. Moreover, it may be associated with higher disease extent.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"933-938"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low awareness of lipid disorders amongst individuals despite their high prevalence.","authors":"Aimee Walsh, Ruth Agar, Greg Offiah, Vincent Maher","doi":"10.1007/s11845-025-03973-w","DOIUrl":"10.1007/s11845-025-03973-w","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerotic cardiovascular disease (ASCVD) usually goes undetected until complications develop. Knowledge and awareness of cardiovascular risk factors, particularly lipid disorders, lead to earlier disease detection and risk factor intervention.</p><p><strong>Aim: </strong>We sought to assess the awareness of lipid disorders in a population randomly screened for lipid abnormalities.</p><p><strong>Methods: </strong>As part of a national awareness campaign, 360 individuals underwent lipid screening and completed a questionnaire regarding their awareness of cardiovascular risk factors.</p><p><strong>Results: </strong>We identified 240 (66%) individuals with a lipid disorder. Lipid disorders were unrelated to gender but increased sharply from 39% in those under 40 years of age to (71%) in those between 40 and 54 years and (75%) in those older than 55 years. They were more prevalent in those reporting diabetes (78%), hypertension (88%) and hypercholesterolaemia (90%) but not in smokers 62% versus non-smokers 68%. Awareness of abnormal lipids was present in only 34% of individuals overall but was higher in those with diabetes (70%) hypertension (64%) or in those with two or more risk factors (50%). Awareness of lipid disorders increased with age, being extremely low (8%) in those under 40 years of age and increasing to (28%), (45%) and (54%) in those aged 40 to 54 years, 55 to 70 years and older than 70 years, respectively. The biggest gap between the presence and awareness of lipid disorders occurred in the 40 to 54 year age group. There were significant correlations between the awareness of lipid disorders and the awareness of hypertension r = 0.27, p < 0.01 or diabetes r = 0.14, p < 0.05 but not of smoking r =  - 0.04 or family history of ASCVD r = 0.11.</p><p><strong>Conclusions: </strong>Given the importance of early detection and intervention to reduce cardiovascular disease risk factors, public education and increased screening are advisable, especially for lipid disorders in the youngerage groups.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"867-872"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The patient perspective on use of Omalizumab in the in-hospital setting.","authors":"Lara Dungan, Fiona Little, Niamh O'Connor, Fionnuala Cox","doi":"10.1007/s11845-025-03978-5","DOIUrl":"10.1007/s11845-025-03978-5","url":null,"abstract":"<p><strong>Background: </strong>Omalizumab is approved for the treatment of chronic spontaneous urticaria (CSU), allergic asthma, and chronic rhinosinusitis with nasal polyps. While self-administration is licensed in Ireland, reimbursement restrictions require hospital-based delivery, placing significant burdens on patients and healthcare services.</p><p><strong>Aims: </strong>To evaluate patient perspectives on hospital-based administration of Omalizumab, and assess the practical, financial, and environmental implications of current practices, alongside interest in transitioning to home-based therapy.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among patients receiving Omalizumab in a tertiary referral hospital between December 2024 and January 2025. Eligible participants (n=49) completed a 20- question anonymous questionnaire exploring demographics, treatment burden, and attitudes toward home therapy. Cost data were obtained from institutional finance records.</p><p><strong>Results: </strong>Among 49 respondents (98% response rate), 46.9% reported personal costs of €11-€50 per hospital visit, with some incurring over €1,300 annually. Over one quarter (26.5%) missed more than 11 workdays per year due to treatment. Most travelled by private vehicle, generating an estimated 2.1 tonnes of CO₂ annually. A majority (77.5%) would prefer home therapy, citing convenience, flexibility, and reduced financial burden. Annual institutional costs for hospital-based administration of Omalizumab exceeded €1 million, excluding drug expenditure.</p><p><strong>Conclusions: </strong>Hospital-based administration of Omalizumab imposes significant patient and system-level costs. These findings support a transition to reimbursed self-administration at home, which may improve patient satisfaction, reduce absenteeism, minimise environmental impact, and achieve considerable healthcare savings.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"793-795"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between serum C-peptide level and diabetic retinopathy according to estimated glomerular filtration rate in patients with type 2 diabetes.","authors":"Jaipal Makina, Moogaambiga S, Rangabashyam S R","doi":"10.1007/s11845-025-03919-2","DOIUrl":"10.1007/s11845-025-03919-2","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic retinopathy is a common complication of diabetes and a leading cause of vision loss. The prevalence of DR increases with the duration of diabetes, poor glycemic control, and the presence of other systemic conditions such as hypertension and dyslipidemia. Serum C-peptide is a marker of endogenous insulin production and is commonly used to assess residual beta-cell function in patients with type 2 diabetes (T2D).</p><p><strong>Objectives: </strong>To examine the relationship between serum C-peptide levels and diabetic retinopathy in patients with type 2 diabetes, categorized according to their estimated glomerular filtration rate.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in VINAYAKA MISSION'S KIRUPANANDA VARIYAR MEDICAL COLLEGE AND HOSPITALS, VINAYAKA MISSION'S RESEARCH FOUNDATION, (DU), in the Department of General Medicine. The study was performed between September 2023 and July 2024. A total of 120 patients who had diabetes mellitus attending the OPD were included in the study. Blood samples were taken to measure serum C-peptide levels, fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c). Serum C-peptide levels were measured using an electrochemiluminescence immunoassay. Also, eGFR was calculated using the CKD-EPI equation based on serum creatinine levels.</p><p><strong>Results: </strong>The majority of the participants had more than 10 years of diabetes (51.7%), while 48.3% had less than 10 years of diabetes. The mean HbA1c value was 8.2 ± 1.5, and the mean Serum C-peptide was 2.3 ± 1.1 ng/mL. The prevalence of diabetic retinopathy among the study participants was 45.0%.</p><p><strong>Conclusion: </strong>Serum C-peptide levels are significantly correlated with both diabetic retinopathy and kidney function. Lower C-peptide levels (reflecting worse beta-cell function) are associated with a higher risk of retinopathy and worse kidney function.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"873-877"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International surgical fellowships in the USA: the pathway to success.","authors":"Ian S Reynolds, Nicholas P McKenna, Kellie L Mathis, William R Perry","doi":"10.1007/s11845-025-03936-1","DOIUrl":"10.1007/s11845-025-03936-1","url":null,"abstract":"<p><p>International surgical fellowships offer senior trainees the opportunity to experience alternative health systems and learn novel cutting-edge techniques. They might also offer trainees exposure to a job market that they had not considered before. Obtaining a surgical fellowship in a reputable North American institution has been the chosen pathway for generations of Irish surgical trainees, yet it is not always a straightforward pathway. The following manuscript highlights the necessary preparation and key steps required to be a successful candidate in the search for a fellowship. It details some key pieces of advice surrounding the application and interview process and provides some guidance on how to choose a programme that will best suit your needs and meet your expectations.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1113-1116"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Klotho protein level in patients with thyroid dysfunction.","authors":"Noor Abd Al-Hakeem Abdullah, Ekhlas Abdallah Hassan","doi":"10.1007/s11845-025-03937-0","DOIUrl":"10.1007/s11845-025-03937-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study focused on determining the new marker Klotho and its correlation with other parameters in thyroid dysfunction.</p><p><strong>Methods: </strong>Seventy-seven thyroid dysfunction patients were recruited during the period (from Aug 2024 to Dec 2024) with an age range (33-56) years. The patient group was subdivided into two groups: group I (21) Patients with Hyperthyroidism and group II (56) Patients with Hypothyroidism, for comparison, 30 healthy individuals were included as a control. The protein level Klotho was estimated using ELISA. Biochemical parameters; blood urea, creatinine, and lipid profile were measured spectrophotometrically. T3, T4 and TSH were determined using ELFA kit.</p><p><strong>Results: </strong>Serum levels of Klotho protein were significantly lower (p-value < 0.001) in group I compared to the control group. There was a significant difference (p < 0.001) in the Klotho protein levels in group II compared with the control group. Klotho protein was negatively correlated to TSH, creatinine concentrations, and age. The AUC was excellent with high diagnostic accuracy in differentiating newly diagnosed thyroid dysfunction from the healthy subject group.</p><p><strong>Conclusions: </strong>Serum Klotho levels in patients with thyroid dysfunction significantly decreased, particularly in hypothyroidism patients. These levels are inversely correlated with thyroid-stimulating hormone levels and age.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"879-885"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term health consequences of COVID-19 in young adults: a focus on respiratory and cardiovascular endurance.","authors":"Manohara H G, Megha Bhat Agni, Damodara Gowda K M","doi":"10.1007/s11845-025-03950-3","DOIUrl":"10.1007/s11845-025-03950-3","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has significantly impacted health, extending beyond the acute phase of illness. Among young adults, \"long COVID\" has raised concerns regarding respiratory and cardiovascular endurance. This study evaluates pulmonary function test (PFT), distance travelled in the 6-min walk test (6MWT), and changes in SpO2 and respiratory rate before and after 6MWT in COVID-19 convalescent patients compared to healthy controls.</p><p><strong>Methods: </strong>This case-control study included 45 controls and 45 COVID-19 convalescent patients confirmed by RT-PCR. Data on PFT, distance travelled in 6MWT, SpO2, and respiratory rate were collected. The associations were analyzed using the Student t-test and ANOVA, with p < 0.05 considered significant.</p><p><strong>Results: </strong>Significant reductions were observed in FVC (p = 0.02), FEV₁ (p = 0.007), FEF_25% (p = 0.0001), FEF_50% (p = 0.003), FEF_25-75% (p = 0.02), and PEFR (p = 0.0001), with an increased lung age (p = 0.01) in COVID-19 convalescent patients compared to controls. No significant difference was observed in FEV₁/FVC ratio, FEV₃, FEV₃/FVC ratio, or FEF_75%. While percentage saturation of oxygen, respiratory rate, and distance travelled in 6MWT showed no significant differences between groups, respiratory rate (p = 0.0001) and pulse rate (p = 0.001) differed significantly before and after 6MWT.</p><p><strong>Conclusions: </strong>COVID-19 convalescent patients exhibited significant declines in FVC, FEV₁, FEF_25%, FEF_50%, and FEF_25-75%, indicating potential restrictive or obstructive lung defects. Increased lung age also suggests long-term impacts of SARS-CoV-2 on respiratory performance.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1021-1029"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes and knowledge relating to advance healthcare directives among psychiatry staff in Ireland.","authors":"Maria Redahan, Catherine Rock, Michal Grudzien, Brendan D Kelly","doi":"10.1007/s11845-025-03943-2","DOIUrl":"10.1007/s11845-025-03943-2","url":null,"abstract":"<p><strong>Background: </strong>Advance healthcare directives are the subject of increased interest in psychiatry. A new legislative framework for advance healthcare directives came into effect in Ireland in 2023 in the Assisted Decision Making (Capacity) Act, 2015.</p><p><strong>Aim: </strong>To investigate levels of knowledge about, and attitudes towards, advance healthcare directives among multidisciplinary psychiatry inpatient staff in Ireland one year after commencement of the new legislation.</p><p><strong>Methods: </strong>A survey was completed among psychiatry inpatient staff (n = 51) in Tallaght University Hospital, Dublin, Ireland between June and August 2024.</p><p><strong>Results: </strong>Majorities of psychiatry inpatient staff have heard of advance healthcare directives (84.3%), think they are a good idea (90.2%), and recommend involving medical staff (84.3%) and/or family and friends (68.6%) in writing them. There are high levels of confidence that staff would respect and be able to access advance healthcare directives when needed, but divided opinions on whether patients understand enough about advance healthcare directives. A majority of staff members (74.5%) would prefer an advance care plan that was not legally binding but still included the patient's will and preferences.</p><p><strong>Conclusions: </strong>Psychiatry inpatient staff are largely supportive of advance healthcare directives but identify needs for more patient education and an explicit option for non-binding, rather than binding, advance healthcare directives.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1049-1052"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of mindfulness combined with exercise compared with a self-management guide on measures of nervous system sensitivity in individuals with chronic pain: a pilot randomised control trial.","authors":"Orla Deegan, Brona M Fullen, Catherine M Doody","doi":"10.1007/s11845-025-03947-y","DOIUrl":"10.1007/s11845-025-03947-y","url":null,"abstract":"<p><strong>Background: </strong>This study described a sensory profile of participants with chronic pain (CP) in a previously reported feasibility RCT, in terms of quantitative sensory testing (QST) measures and the Central Sensitisation Inventory (CSI).</p><p><strong>Aims: </strong>The study aimed to explore the changes in QST measures and the CSI in this sample following participation in a mindfulness and physical activity intervention compared to an online self-management guide.</p><p><strong>Methods: </strong>Participants were randomised into (i) a combined mindfulness and exercise online interactive group or (ii) an online self-management group. Pressure pain thresholds (PPT), temporal summation (TS), conditioned pain modulation (CPM) measures, and the CSI were completed with participants at baseline and post-intervention.</p><p><strong>Results: </strong>Baseline (n = 33) and post-intervention (n = 22) measurements were completed. High mean CSI scores (54.69, SD 23.85) were noted at baseline in participants, indicating the presence of central sensitisation [n = 33; 70% (n = 23) score > 40]. Mean baseline scores for TS were high (2.64, SD 1.60), indicating the presence of pain facilitation, and variable results were observed for baseline PPT and CPM measures. The combined intervention was not found to be superior to a self-management guide in this cohort in terms of changes in PPT, TS, and CPM measures and the CSI.</p><p><strong>Conclusions: </strong>High baseline CSI and TS scores were identified in the cohort at baseline, with no notable trends identifiable with regard to changes in QST scores or the CSI post-intervention. Further studies are recommended with larger sample sizes in order to understand changes in QST measures following participation in interventions of this nature.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1167-1176"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}