Irish Journal of Medical Science最新文献

{"title":"miR-326 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability.","authors":"Suna Ni, Qian Zhao, Fengjiao Hu","doi":"10.1007/s11845-025-04042-y","DOIUrl":"https://doi.org/10.1007/s11845-025-04042-y","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the diagnostic value and mechanism of action of miR-326 in gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>The study population consisted of 98 GDM patients and 71 healthy pregnant women. Subjects' serum were collected early in pregnancy (10-12 weeks) for cryopreservation. Gene expression was analyzed by RT-qPCR. miR-326 was evaluated by ROC for its diagnostic value. Pearson correlation analysis was performed to calculate the relationship between miR-326 and glycemic index and TLR4. Logistic analysis resulted in risk factors for adverse pregnancy outcomes. CCK8, transwell, and flow cytometry were performed to observe changes in trophoblast function after different treatments. DLR verified the targeting relationship between genes.</p><p><strong>Results: </strong>miR-326 is upregulated in early pregnancy serum of GDM patients and has a predictive diagnostic value for GDM. There is a positive correlation between miR-326 and glycemic indices (HbA1c, FBG, HOMA-IR) in GDM patients, which is a risk factor for inducing adverse pregnancy outcomes. miR-326 inhibitor restored the proliferation, migration, and invasion ability of high glucose-treated (HG group) cells and reduced apoptosis. TLR4 is a target gene of miR-326, and the expression of the two is negatively correlated in GDM patients. Transfection of si-TLR4 resisted the changes in trophoblast cells induced by the use of miR-326 inhibitor.</p><p><strong>Conclusion: </strong>High levels of miR-326 are upregulated in serum of GDM patients in early pregnancy. miR-326 targeted inhibition of TLR4 causes abnormal trophoblast cell function and induces adverse pregnancy outcomes in GDM patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the timing of catheter removal on postoperative urinary continence after radical prostatectomy: a systematic review and meta-analysis.","authors":"Zhenlang Guo, Jun Pan, Zhaohui Wang, Guixing Tang, Franky Leung Chan, Zunguang Bai, Junwei He","doi":"10.1007/s11845-025-04075-3","DOIUrl":"https://doi.org/10.1007/s11845-025-04075-3","url":null,"abstract":"<p><strong>Background: </strong>The optimal length of postoperative catheterisation time after radical prostatectomy remains to be controversial. We performed a meta-analysis to explore the impact of catheter removal time on urinary continence after radical prostatectomy (RP).</p><p><strong>Methods: </strong>The MEDLINE, Embase, Cochrane Library, and Web of Science databases were searched to identify eligible studies published before June 2025. The inverse variance method with random-effects modeling was used to calculate summary odds ratios (ORs) and their associated 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Fifteen studies comprising 4,159 patients who underwent RP matched our eligibility criteria. Early catheter removal was associated with an increased likelihood of urinary retention (OR = 2.20, 95% CI: 1.22-3.95) in the postoperative day (POD) 2 group compared to more than POD 2 days group. However, this significant difference was not observed in patients with POD 3 (vs POD > 3, OR = 1.37, 95% CI: 0.37-5.09), patients with POD 4 (vs POD > 4, OR = 4.41, 95% CI: 0.88-22.18), and patients with POD 7 (vs POD > 7, OR = 6.49, 95% CI: 0.80-52.83). Moreover, early removal of the catheter was not associated with an increased risk of urinary incontinence (OR = 1.25, 95% CI: 0.58-2.68), anastomotic leakage (OR = 1.22, 95% CI: 0.76-1.96), vesical neck stenosis (OR = 0.73, 95% CI: 0.09-5.83) compared to the regular group. The findings are robust, as indicated by sensitivity and meta-regression analyses.</p><p><strong>Conclusions: </strong>Early catheter removal seems feasible, but one should be aware of the increased risk of urinary retention, especially in patients of POD 2. Moreover, it seems to be safe in terms of urinary incontinence, anastomotic leakage, and vesical neck stenosis. We hope that our findings will help to guide the standardised management of catheter removal after RP, and early catheter-free discharge after RP may provide relevant clinical benefits for these patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why do patients attend out-of-hours GP services in Ireland?","authors":"Aisling Farrell, Alannah McCarthy, Roseanne Tobin, Elizabeth Bowen, Audrey Russell, Aisling Jennings","doi":"10.1007/s11845-025-04071-7","DOIUrl":"10.1007/s11845-025-04071-7","url":null,"abstract":"<p><strong>Background: </strong>The attendance at out-of-hours GP services in Ireland has increased over the last number of years. However, the reasons for the increased demand have not been explored in the literature.</p><p><strong>Aims: </strong>The aim of this study was to identify the factors contributing to the use of out-of-hours GP services in Ireland from the patient's perspective.</p><p><strong>Methods: </strong>A survey was designed and piloted prior to distribution. The survey was completed by patients attending an out-of-hours GP treatment centre in Cork, Ireland over a four-month period. Using a combination of forced choice items, free text boxes and five-point Likert scales, questions explored the reasons for attendance and experiences of patients with the out of hours service. Descriptive statistics were used to analyse the data on MS Excel.</p><p><strong>Results: </strong>80 people completed the survey. 75% (60/80) of participants stated that they had not attempted to contact their GP prior to contacting the out-of-hours centre. 49% (39/80) contacted the out-of-hours service as they felt that their issue was urgent. 36% (29/80) stated that they were unable to obtain an appointment with their GP and 15% (12/80) stated that the out-of-hours service was more convenient than regular GP hours. 29% (23/80) had symptoms for more than 4 days prior to contacting out-of-hours. The most common presentation was coryzal and upper respiratory tract symptoms, grouped collectively as 'Ear Nose and Throat' (ENT) symptoms at 34% (27/80).</p><p><strong>Conclusions: </strong>This study provides insight into the factors driving patient attendance at the out-of-hours GP service in Ireland. These factors include perceived urgency of symptoms, an inability to obtain an appointment with their own GP and in some cases, the convenience of out-of-hours services. There is a demand for targeted patient educational campaigns and increased resourcing for GP services during the daytime to reduce reliance on out-of-hours GP services.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold-water, Sulphur and 'the itch': James Henry's principles for conducting controlled trials (1843).","authors":"Max Cooper, Jo Middleton, Sarah Cooper","doi":"10.1007/s11845-025-04027-x","DOIUrl":"https://doi.org/10.1007/s11845-025-04027-x","url":null,"abstract":"<p><strong>Background: </strong>James Henry (1798-1876) was a Dublin physician and classical scholar best remembered for his translation of Virgil's Aeneid. Little is recorded about his medical practice.</p><p><strong>Aim: </strong>To describe Henry's 1843 proposal for a controlled trial of treatment for 'the itch'.</p><p><strong>Method: </strong>Qualitative examination of historical medical journals.</p><p><strong>Results: </strong>Henry suggests taking twelve patients and treating six with cold-water treatment and six with standard treatment (sulphur). Henry's proposal sets out four general principles for selecting diseases to study the alleged benefits of cold-water treatment. First, the condition should be one upon which it is safe to experiment. Second, the disease should be 'visible and tangible, and… cannot be simulated or misrepresented, or misunderstood'. Third, it should have no spontaneous recovery. Finally, there should already be a 'certain [i.e. proven] remedy'. Henry had published in 1834 on sulphur as a laxative. By calling for twelve participants, it is possible that Henry's proposal was influenced by the writing of Francis Hauksbee the Younger (1743) and James Lind (1753).</p><p><strong>Conclusion: </strong>Although there is no evidence that Henry's trial ever took place, his proposal and principles for selecting a disease to study reveal a critical and ethical mind. It also constitutes a notable landmark on the journey towards formal controlled trials.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of royal jelly consumption on oxidative stress, anti-oxidant markers and physical activities of patients with multiple sclerosis: a randomized double-blind placebo-controlled study.","authors":"Zahra Eslamifar, Farzaneh Manucheri, Saeed Ghanbari, Mohammadreza Zandi, Susan Sabbagh","doi":"10.1007/s11845-025-04009-z","DOIUrl":"https://doi.org/10.1007/s11845-025-04009-z","url":null,"abstract":"<p><strong>Background: </strong>The study investigates the effects of royal jelly (RJ) on patients with relapsing-remitting multiple sclerosis (RRMS), focusing on its potential to reduce oxidative stress, improve antioxidant levels, and enhance quality of life.</p><p><strong>Methods: </strong>A total of 61 RRMS patients were randomly assigned to either a RJ group or a placebo group, receiving a daily dose of 500 mg for 45 days. Key outcomes measured included expanded disability status scale (EDSS) scores, levels of malondialdehyde (MDA), and activities of antioxidants such as catalase (CAT) and superoxide dismutase (SOD), along with assessments of fatigue and quality of life.</p><p><strong>Results: </strong>Results indicated that the RJ group experienced a significant reduction in EDSS scores (P < 0.001) and MDA levels (P < 0.0001). The activity of SOD and CAT after consumption of RJ had increased significantly (P < 0.0001, P < 0.001), respectively. Additionally, improvements were noted in some parameters of fatigue and quality of life measures.</p><p><strong>Conclusion: </strong>The findings suggest that RJ may help decrease oxidative stress and improve motor function and anti-oxidant capacity in MS patients, potentially slowing disease progression.</p><p><strong>Trial registration: </strong>This study was registered on the Iranian Registry of Clinical Trials (Registration No. IRCT20220116053732N1) on 2022.05.08.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of plantar pressure distribution patterns of patients with ankylosing spondylitis and asymptomatic healthy individuals: a cross-sectional study.","authors":"Nazli Cigercioglu, Zilan Bazancir-Apaydin, Gul Baltaci, Umut Kalyoncu, Hande Guney-Deniz","doi":"10.1007/s11845-025-04064-6","DOIUrl":"https://doi.org/10.1007/s11845-025-04064-6","url":null,"abstract":"<p><strong>Background: </strong>Ankylosing Spondylitis (AS) is an inflammatory chronic disease that causes postural changes. As a result of these changes decreased hip flexion, increased knee flexion and plantar flexion of ankle are developed.</p><p><strong>Aims: </strong>The aim of the study is to compare plantar pressure distribution results in patients with AS and healthy individuals and to determine the relationship between clinical and functional parameters in patients with AS.</p><p><strong>Methods: </strong>Twenty-five patients (median age = 42.2 ± 2.1 years) with AS and 25 healthy individuals (median age = 44.4 ± 1.7 years) were included in the study. The maximum foot pressure (FP_max), average pressure, center of pressure angle (CoP), forefoot load (FFL), rearfoot load (RFL), foot progression angle (FPA) and foot angle (FA) were determined by pedobarographic analysis. Spinal mobility was assessed with lumbar flexion, lateral flexion, and tragus-wall distance. Functional status and disease-related symptoms were assessed with BASDAI, BASFI and ASQoL.</p><p><strong>Results: </strong>There were no differences between static and dynamic pedobarographic analysis parameters between the AS group and the control group (p > 0.05). Self-rated functional levels parameters, pain, and stiffness were higher in the AS group (p < 0.05). Lumbar flexion (p = 0.187) and tragus-to-wall distance (p = 0.196) were similar in two groups. Self-rated parameters were correlated with pain, stiffness, and lateral flexion (p < 0.05). Lateral flexion correlated with FA and FFL; tragus to wall distance correlated with FP_max and CoP and RFL; lumbar flexion correlated with FA (p < 0.05).</p><p><strong>Conclusion: </strong>The results showed that there was no difference plantar pressure distribution but there was a difference in spinal mobility in AS group compared healthy individuals.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PANoptosis-related gene APAF1 may contribute to the progression of sepsis.","authors":"Zhiqin Kang, Jing Huang, Hongxuan Liu","doi":"10.1007/s11845-025-04041-z","DOIUrl":"https://doi.org/10.1007/s11845-025-04041-z","url":null,"abstract":"<p><strong>Background: </strong>This research tried to identify a PANoptosis-related gene marker for sepsis early diagnosis and treatment.</p><p><strong>Methods: </strong>We collected transcriptional datasets from the Gene Expression Omnibus (GEO) database and performed differential expression analysis using the R language and the \"limma\" package. Functional enrichment analysis was conducted using the \"clusterProfiler\" package, and Protein-Protein Interaction (PPI) analysis was carried out. Transcription factor (TF) binding sites were predicted using FIMO tool. Gene set enrichment analysis (GSEA) and disease ontology (DO) analysis were performed. Immune infiltration analysis was conducted using CIBERSORT, ssGSEA, and the xCell algorithm.</p><p><strong>Results: </strong>A total of 18 PANoptosis-related genes were found to express significantly differentially between sepsis and normal samples, and APAF1 was selected as the target gene. APAF1 expressed higher in sepsis compared to normal samples. ROC analysis indicated its diagnostic value. TF HIF1A and 4 miRNAs might be regulators of APAF1. APAF1 was negatively related to CD8 T cells and resting NK cells, and positively related neutrophils, macrophages M0, T cells gamma delta, and plasma cells. Many target drugs were detected high sensitivity to APAF1 and its related TFs.</p><p><strong>Conclusion: </strong>PANoptosis-related gene APAF1 was identified to highly express in sepsis and it was valuable in diagnosis.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between cognitive function and physical performance in established users of a lower limb prosthesis.","authors":"Senem Demirdel, Rahime Yılmaz, Selma Küçük, Osman Söyler","doi":"10.1007/s11845-025-04049-5","DOIUrl":"https://doi.org/10.1007/s11845-025-04049-5","url":null,"abstract":"<p><strong>Background: </strong>Cognitive abilities are important for mobility functions in individuals with amputation.</p><p><strong>Aims: </strong>To investigate the association between cognitive function and physical performance in established users of a lower limb prosthesis.</p><p><strong>Methods: </strong>This prospective cross-sectional study was included established users of a lower limb prosthesis (N = 62; mean age ± SD, 41.33 ± 14.76 years). The Montreal Cognitive Assessment was used to evaluate cognitive function. The Timed Up and Go Test under single-task and dual-task conditions, the Four Square Step Test, and the 3-m Backward Walk Test were used for physical performance assessment.</p><p><strong>Results: </strong>An independent association was found of the Montreal Cognitive Assessment to the dual task Timed Up and Go Test (AdjR² = 0.168, p = 0.003), the Four Square Step Test (AdjR² = 0.25, p = 0.003) and the 3-m Backward Walk Test (AdjR² = 0.159, p = 0.032). An increase of 1 point in the Montreal Cognitive Assessment was associated with a reduction of 0.681 s (95% CI, 1.116-0.246) in the the dual task Timed Up and Go Test, 0.378 s (95% CI, 0.617-0.138) in the Four Square Step Test, and 0.255 s (95% CI, 0.487-0.022) in the 3-m Backward Walk Test.</p><p><strong>Conclusions: </strong>The results of this study revealed an independent association between global cognitive function and functional mobility under dual-task conditions, dynamic balance, and backward walking performance in established users of a lower limb prosthesis. These results emphasize that cognitive functions should be taken into account in interventions aimed at improving challenging physical performance in established users of a lower limb prosthesis.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-gestational diabetes: benefits and barriers to attendance at pre-pregnancy clinics.","authors":"Cathriona Murphy, Linda Culliney, Sinead Whelan, Louise O'Mahony, Ashling Kennedy, Michelle Sugrue, Adrianne Wyse, Oratile Kgosidialwa, Mairead O'Riordan, Antoinette Tuthill","doi":"10.1007/s11845-025-04037-9","DOIUrl":"https://doi.org/10.1007/s11845-025-04037-9","url":null,"abstract":"<p><strong>Background: </strong>Pre-gestational diabetes mellitus increases the risk of adverse pregnancy outcomes. Pre-pregnancy clinics are a well-established and cost-effective way of reducing pregnancy complications.</p><p><strong>Aims: </strong>This study aimed to review outcome differences between women with pre-gestational diabetes who did/did not attend pre-pregnancy clinics and to evaluate barriers to attendance.</p><p><strong>Methods: </strong>1) A retrospective study examined data from all women with pre-gestational diabetes who received obstetric care in Cork University Maternity Hospital 2015-2019. 2) A cross-sectional survey of women attending antenatal clinics during the study period. A telephone questionnaire was completed to understand facilitators and barriers to pre-pregnancy attendance.</p><p><strong>Results: </strong>Two hundred women were included retrospectively: 65.5% with Type1 diabetes, and 30.5% with type 2 diabetes. Only 26% (52) attended pre-pregnancy clinics. Although there were no differences in miscarriage rate, congenital anomaly, mode of delivery or neonatal intensive care unit admission between groups, the mean birth weight of babies born to women who attended pre-pregnancy clinics was less than those who did not attend (3294.5 ± 753.0 g vs. 3598.8 ± 802.8 g; p = 0.02). Twenty-eight women were included cross-sectionally, nine of whom attended pre-pregnancy clinics. All who attended found it useful. Eight participants proposed a hybrid clinic model to optimise future service engagement. Increasing awareness was advocated by many participants.</p><p><strong>Conclusion: </strong>Attendance at pre-pregnancy clinics is low. Lack of awareness is the greatest barrier reported to attendance. To optimise perinatal outcomes, efforts are required to increase attendance; this may be facilitated by increasing awareness of these clinics, as suggested by the women themselves.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-dialysis serum osmolality as a predictor of interdialytic weight gain in diabetic and non-diabetic hemodialysis patients: a cross-sectional study.","authors":"Seckin Akben, Engin Onan, Feyza Nur Sarısık, Fatma Betul Guzel, Ilyas Ozturk, Muhammed Seyithanoglu, Mustafa Saglam, Rumeysa Gulmez, Ertugrul Erken, Ozkan Gungor, Orcun Altunoren","doi":"10.1007/s11845-025-04069-1","DOIUrl":"https://doi.org/10.1007/s11845-025-04069-1","url":null,"abstract":"<p><strong>Background: </strong>Excessive interdialytic weight gain (IDWG) in hemodialysis is associated with high mortality. Limited evidence suggests that diabetes (DM) may exacerbate IDWG. We aimed to investigate whether the presence of diabetes and diabetes control have an effect on IDWG.</p><p><strong>Methods: </strong>Diabetic and non-diabetic hemodialysis patients were included in the study. Blood samples were drawn at the end of the midweek dialysis session and just before the next session to measure blood urea nitrogen, creatinine, sodium, glucose, serum osmolality, and copeptin levels. IDWG was calculated, and patients were categorized based on their diabetes control status and IDWG.</p><p><strong>Results: </strong>Eighty-six hemodialysis patients (33 with DM, 53 without DM) were included in the study. Mean age was 52.4 years. IDWG and serum copeptin levels of diabetic and non-diabetic patients were not different but post-dialytic osmolality, HbA1c and blood glucose were higher in diabetics. While the post-dialytic osmolality of patients with an IDWG > 3 kg was higher than that of patients with an IDWG of < 3 kg, HbA1c and blood sugar levels were not different. Regression analysis involving copeptin, Na, HbA1c, osmolality, glucose, and interdialytic blood glucose revealed only osmolality significantly affected IDWG (p = 0.006). For every 10 mmol increase in osmolality, IDWG increased by 0.5 kg. Copeptin, Na, HbA1c, glucose, and interdialytic blood glucose had no significant impact on IDWG.</p><p><strong>Conclusions: </strong>In conclusion, this study highlights the importance of monitoring post-dialysis serum osmolality in hemodialysis patients, as it appears to be a significant factor in determining IDWG independent of the presence of DM.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}