Irish Journal of Medical Science最新文献

{"title":"Attitudes and knowledge relating to advance healthcare directives among psychiatry staff in Ireland.","authors":"Maria Redahan, Catherine Rock, Michal Grudzien, Brendan D Kelly","doi":"10.1007/s11845-025-03943-2","DOIUrl":"10.1007/s11845-025-03943-2","url":null,"abstract":"<p><strong>Background: </strong>Advance healthcare directives are the subject of increased interest in psychiatry. A new legislative framework for advance healthcare directives came into effect in Ireland in 2023 in the Assisted Decision Making (Capacity) Act, 2015.</p><p><strong>Aim: </strong>To investigate levels of knowledge about, and attitudes towards, advance healthcare directives among multidisciplinary psychiatry inpatient staff in Ireland one year after commencement of the new legislation.</p><p><strong>Methods: </strong>A survey was completed among psychiatry inpatient staff (n = 51) in Tallaght University Hospital, Dublin, Ireland between June and August 2024.</p><p><strong>Results: </strong>Majorities of psychiatry inpatient staff have heard of advance healthcare directives (84.3%), think they are a good idea (90.2%), and recommend involving medical staff (84.3%) and/or family and friends (68.6%) in writing them. There are high levels of confidence that staff would respect and be able to access advance healthcare directives when needed, but divided opinions on whether patients understand enough about advance healthcare directives. A majority of staff members (74.5%) would prefer an advance care plan that was not legally binding but still included the patient's will and preferences.</p><p><strong>Conclusions: </strong>Psychiatry inpatient staff are largely supportive of advance healthcare directives but identify needs for more patient education and an explicit option for non-binding, rather than binding, advance healthcare directives.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1049-1052"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of mindfulness combined with exercise compared with a self-management guide on measures of nervous system sensitivity in individuals with chronic pain: a pilot randomised control trial.","authors":"Orla Deegan, Brona M Fullen, Catherine M Doody","doi":"10.1007/s11845-025-03947-y","DOIUrl":"10.1007/s11845-025-03947-y","url":null,"abstract":"<p><strong>Background: </strong>This study described a sensory profile of participants with chronic pain (CP) in a previously reported feasibility RCT, in terms of quantitative sensory testing (QST) measures and the Central Sensitisation Inventory (CSI).</p><p><strong>Aims: </strong>The study aimed to explore the changes in QST measures and the CSI in this sample following participation in a mindfulness and physical activity intervention compared to an online self-management guide.</p><p><strong>Methods: </strong>Participants were randomised into (i) a combined mindfulness and exercise online interactive group or (ii) an online self-management group. Pressure pain thresholds (PPT), temporal summation (TS), conditioned pain modulation (CPM) measures, and the CSI were completed with participants at baseline and post-intervention.</p><p><strong>Results: </strong>Baseline (n = 33) and post-intervention (n = 22) measurements were completed. High mean CSI scores (54.69, SD 23.85) were noted at baseline in participants, indicating the presence of central sensitisation [n = 33; 70% (n = 23) score > 40]. Mean baseline scores for TS were high (2.64, SD 1.60), indicating the presence of pain facilitation, and variable results were observed for baseline PPT and CPM measures. The combined intervention was not found to be superior to a self-management guide in this cohort in terms of changes in PPT, TS, and CPM measures and the CSI.</p><p><strong>Conclusions: </strong>High baseline CSI and TS scores were identified in the cohort at baseline, with no notable trends identifiable with regard to changes in QST scores or the CSI post-intervention. Further studies are recommended with larger sample sizes in order to understand changes in QST measures following participation in interventions of this nature.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1167-1176"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let-7a microRNA modulates caspase-3-dependent apoptosis in melanoma cells treated with dabrafenib and trametinib combination.","authors":"Murat Keser, Harika Atmaca","doi":"10.1007/s11845-025-03923-6","DOIUrl":"10.1007/s11845-025-03923-6","url":null,"abstract":"<p><strong>Background: </strong>Malignant melanoma is an aggressive tumor with high resistance to therapy. The emergence of RAS-driven secondary cancers and BRAF-inhibitor resistance has led to the development of combination therapies targeting both BRAF and MEK.</p><p><strong>Aims: </strong>This study explored the mechanisms underlying the synergistic effects of dabrafenib (DAB) and trametinib (TM) in drug-resistant A375 and RPMI 7951 melanoma cells.</p><p><strong>Methods: </strong>Cytotoxicity was assessed via MTT assay and combination effects were evaluated via combination index analysis. Apoptosis was analyzed by DNA fragmentation ELISA, while ectopic let-7a miRNA expression and inhibition were performed using lipofection. Gene expression levels were quantified by qRT-PCR, and protein expression was assessed via Western blot.</p><p><strong>Results: </strong>The combination of 0.7 μM DAB and 5.0 μM TM exhibited synergistic cytotoxicity by inhibiting the pERK1/2 signaling pathway and inducing MITF expression. This resulted in mitochondria-mediated apoptosis, characterized by a decrease in anti-apoptotic Bcl-2 and an increase in pro-apoptotic Bax, caspase-9, and caspase-3 levels. Additionally, Let-7a was identified as a crucial regulator of apoptosis sensitivity by targeting caspase-3, the key executor of apoptosis.</p><p><strong>Conclusions: </strong>These findings provide new insights into overcoming melanoma drug resistance through combined BRAF/MEK inhibition.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"797-805"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive study of laser use in dermatology: assessing the safety, innovations, and effectiveness of laser technology for skin treatment.","authors":"Zahra Al Timimi, Abeer Fauzi Al-Rubaye, Donia Mohsen Diwan","doi":"10.1007/s11845-025-03942-3","DOIUrl":"10.1007/s11845-025-03942-3","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this review article is to provide a general overview of the development of laser technology and its applications in dermatology. It will describe the mechanism, effectiveness, and hazardous characteristics of different laser modalities used for the treatment of skin diseases, such as disorders of pigmentation, vascular malformations, acne scarring, and photoaging.</p><p><strong>Methods: </strong>There was a thorough literature review through databases such as Scopus and PubMed, along with Google Scholar. Articles from 2000 to 2023 that were peer-reviewed were included. In addition to pulsed dye lasers, the search terms used in the literature review involved \"laser dermatology,\" \"skin treatment,\" and names of specific lasers such as carbon dioxide (CO₂), Er: YAG, and Nd: YAG. Information on adverse effects, long-term effects, clinical outcomes, and patient satisfaction ratings was gathered.</p><p><strong>Results: </strong>The results show that, in the past 20 years, laser treatment has evolved significantly. Relative to historical approaches, innovations like fractional lasers have been more effective with reduced downtime. For conditions like melasma, as much as acne scars, evaluations show high levels of patient satisfaction from diverse populations. Darker skin types continue to be susceptible to adverse effects like post-inflammatory hyperpigmentation.</p><p><strong>Conclusions: </strong>The efficacy and versatility of laser therapy have made it an anchor of dermatologic practice. Laser technology is continually evolving, with the hope of enhanced results at lower risk. To optimize benefit and minimize side effects, future research should aim to design therapy regimens specific to each skin type.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"923-932"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of compassionate access programmes for novel oncology drugs.","authors":"Sarah A Kelly, Karine E Ronan, Mohammed Zameer, Jennifer Brown, Grainne Johnston, Ruth Adams, Dearbhla Murphy, Deirdre Kelly, Waseem Darwish, John McCaffery, Geraldine O'Sullivan Coyne, Emily Harrold, Shahid Iqbal, Darren Cowzer, Austin G Duffy","doi":"10.1007/s11845-025-03930-7","DOIUrl":"10.1007/s11845-025-03930-7","url":null,"abstract":"<p><strong>Background: </strong>Despite the rise in the number of approved novel oncology drugs, just over half of all new cancer medicines approved by the EMA between 2017 and 2021 were granted reimbursement in Ireland by the HSE. Compassionate access programmes (CAPs) are a means of providing managed access to drugs which are of proven benefit but have not yet received full approval for reimbursement by the state, or where the requested indication has not been yet been authorised/licensed.</p><p><strong>Methods: </strong>A retrospective review was performed of patients attending The Mater hospital for treatment of advanced malignancy who availed of a CAP between August 2012 and July 2022. Clinical data collected included disease type, treatment received, duration of treatment received, and best response to treatment. To categorize outcome \"Clinical Benefit\" was defined as a radiological complete, partial, or stable disease response to treatment.</p><p><strong>Results: </strong>One hundred and thirteen patients were included in the study. Ninety-three received at least one dose of CAP treatment. Treatment duration ranged from 0 to 112 months, with 12 patients on treatment for ≥ 2 years. N = 47 (42%) experienced a Clinical Benefit. Of these, N = 7 experienced a complete response [CR]. Thirty patients (27%) did not receive a planned treatment or died within 3 months of treatment.</p><p><strong>Conclusions: </strong>In this review of a decade of CAPs at our institution we observed that a significant proportion of patients derived a clinical benefit from CAP treatment. Unfortunately, however, a significant proportion of patients did not receive a planned treatment due to disease progression or died within 3 months of treatment suggesting availability came too late. While CAPs can provide meaningful benefit, they are not a substitute for timely approval of novel agents.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"807-815"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of stress and earthquake-related trauma on fibromyalgia: a longitudinal study.","authors":"Muhammed Aslan, Irada Ibramkhalilova, Melis Mutlu, Fatih Albayrak, Pinar Gunel, Bunyamin Kisacik","doi":"10.1007/s11845-025-03955-y","DOIUrl":"10.1007/s11845-025-03955-y","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia (FM) is a chronic disorder characterized by widespread pain, fatigue, and psychological symptoms. While psychological trauma is known to affect FM severity, the impact of natural disasters, such as earthquakes, remains insufficiently studied.</p><p><strong>Aim: </strong>This study aimed to evaluate the effects of earthquake-related trauma on fibromyalgia severity and quality of life.</p><p><strong>Methods: </strong>A total of 100 patients diagnosed with fibromyalgia per the American College of Rheumatology 2016 criteria were enrolled. All participants experienced the February 2023 earthquakes in Turkey. Disease activity and quality of life were assessed using the Fibromyalgia Impact Questionnaire (FIQ) at 1 and 6 months post-earthquake. The Impact of Event Scale-Revised (IES-R) was employed to measure psychological trauma levels. Statistical analyses included paired t-tests and Pearson's correlation coefficients.</p><p><strong>Results: </strong>FIQ scores significantly improved from 1 month (74.97 ± 20.15) to 6 months (67.25 ± 16.39) post-earthquake (p < 0.001). A strong positive correlation was found between IES-R and FIQ scores at 1 month (r = 0.636, p < 0.01) and 6 months (r = 0.411, p < 0.01). Subgroups with home or family loss showed more pronounced FIQ scores, while groups exposed to new stress factors did not show significant changes over time (p = 0.307).</p><p><strong>Conclusions: </strong>This study demonstrates that earthquake-related trauma exacerbates fibromyalgia symptoms, highlighting the necessity of integrating psychological and stress management interventions in the treatment of FM, particularly in disaster-affected regions.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1179-1182"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTRIAL-IE (ICORG) 15-34: The impact of the 21 gene breast recurrence score® assay on chemotherapy prescribing in oestrogen receptor positive, lymph node positive early stage breast cancer in Ireland.","authors":"W J Mullally, A Hassan, N Keegan, C O'Leary, L McSorley, T Mahgoub, S O'Reilly, J Walshe, M J Kennedy, L Coate, M O'Connor, M Keane, C M Kelly, K Duffy, C G Murphy, M Milewski, S Molloy, K Egan, V Murphy, O S Breathnach, L Grogan, B T Hennessy, P G Morris","doi":"10.1007/s11845-025-03922-7","DOIUrl":"10.1007/s11845-025-03922-7","url":null,"abstract":"<p><strong>Background: </strong>The 21-gene Breast Recurrence Score® (Oncotype DX®) assay has improved the selection of patients for chemotherapy in early breast cancer. Internationally, this test is used in lymph node positive disease, but at the time this study was conducted, it was not reimbursed for this indication in Ireland.</p><p><strong>Aims: </strong>Determine how access to the Recurrence Score® testing reduces chemotherapy use and quantifies the impact on oncologists' treatment recommendations.</p><p><strong>Methods: </strong>Between March and September 2017, 75 patients were enrolled in a prospective study across ten hospitals. Eligible patients had oestrogen/progesterone receptor positive and HER2 negative breast cancer with 1-3 involved lymph nodes. Following informed consent, demographics were collected and questionnaires completed by a consultant medical oncologist before and after the recurrence score testing, which examined expectations of tumour chemosensitivity, strength of chemotherapy recommendation, and planned treatment.</p><p><strong>Results: </strong>Recurrence Scores® were available on 74/75 patients. Overall, access to this test led to a 27% reduction in the recommendation for chemotherapy from 68 (92%) to 48 (65%) patients. This was most notable in patients with one (46 versus 34 patients) and two (13 versus seven patients) involved lymph nodes representing a 26% and 46% reduction, respectively. The reduction in chemotherapy use was marked in women aged 50-70 years with one lymph node involved (28 versus 18 patients)-a 36% reduction.</p><p><strong>Conclusion: </strong>Consistent with our hypothesis, broader access to the Recurrence Score® led to a reduction in the use of chemotherapy in Ireland and has subsequently become standard of care.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"839-846"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the Editor, Commentary on the endoscopic sinus approach for ocular lymphoma.","authors":"Shiona Maria Benedict Fernandes, Ayaanuddin Syed Khaja, Arian Hizomi","doi":"10.1007/s11845-025-03967-8","DOIUrl":"10.1007/s11845-025-03967-8","url":null,"abstract":"","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1177-1178"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of microleakage of four restorative materials using confocal laser scanning microscopy: an in vitro study.","authors":"Annapoorna Kini, Kavana M G, Shubhashini N, Nithin Shetty, Venkata Suresh Venkataiah, Mohammad Fareed, Mohmed Isaqali Karobari","doi":"10.1007/s11845-025-03927-2","DOIUrl":"10.1007/s11845-025-03927-2","url":null,"abstract":"<p><strong>Objective: </strong>Understanding the sealing ability of restorative materials to prevent microleakage and its consequent complications-such as secondary caries, postoperative sensitivity, and restoration failure-is imperative in clinical dentistry. This study aims to compare the microleakage performance of four restorative materials-bioactive composite resin (Activa Pronto), alkasite restorative (Cention N), compomer (Dyract Flow), and glass ionomer cement (Type 2 GIC)-in Class V cavities of extracted premolar teeth.</p><p><strong>Materials and methods: </strong>Forty non-carious, intact premolar teeth were selected and prepared with standardized Class V cavities. The teeth were randomly assigned to one of four groups (n = 10) and restored with the respective materials. The restorations underwent thermocycling, followed by microleakage testing using rhodamine dye. Confocal laser scanning microscopy (CLSM), a technique that provides superior depth resolution and three-dimensional visualization of microleakage, was used to assess dye penetration at the tooth-restoration interface. Microleakage was then scored using a standardized grading system.</p><p><strong>Results: </strong>Significant differences in microleakage were observed among the groups (χ² = 45.69; p < 0.001). Group 1 (bioactive composite resin) demonstrated the lowest microleakage, with predominantly Grade 0 and Grade 1 scores, while Group 4 (GIC) exhibited the highest microleakage, characterized mainly by Grade 3 scores. Bioactive composite resin exhibited significantly lower microleakage than alkasite, compomer, and GIC (p < 0.05). No significant difference was observed between alkasite and compomer.</p><p><strong>Conclusions: </strong>Bioactive composite resin (Activa Pronto) provided the most effective seal against microleakage, followed by alkasite and compomer, with glass ionomer cement showing the least effective sealing properties.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1105-1111"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-92a-3p and miR-182-3p as potential biomarkers for the differential diagnosis of gestational diabetes mellitus and its correlation with pregnancy outcomes.","authors":"Xiaoshuang Du, Qi Li, Zhenlan Wu, Lin Xue","doi":"10.1007/s11845-025-03953-0","DOIUrl":"10.1007/s11845-025-03953-0","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) poses a significant threat to the health of both the mother and the fetus during pregnancy, potentially resulting in adverse pregnancy outcomes (APOs), including preterm labor and obstructed labor.</p><p><strong>Objective: </strong>This study aimed to evaluate the expression of serum microRNA (miR)-92a-3p and miR-182-3p in GDM and their clinical significance, providing ideas for clinical diagnosis and management.</p><p><strong>Methods: </strong>A total of 80 patients with GDM served as the GDM group, and 80 healthy pregnant females served as controls. Quantitative real-time PCR was utilized to examine the relative expression of miR-92a-3p and miR-182-3p. Logistic regression modeling and ROC curves were utilized to evaluate the clinical significance of serum miR-92a-3p and miR-182-3p in GDM.</p><p><strong>Results: </strong>miR-92a-3p and miR-182-3p was upregulated in GDM patients. The expression of miR-92a-3p and miR-182-3p were positively correlated with 1 h OGTT, 2 h OGTT, and HOMA-IR. The ROC curves demonstrated that the areas under the curve (AUCs) of miR-92a-3p, miR-182-3p, and the combination of the two in the diagnosis of GDM were 0.890, 0.813, and 0.921, respectively. Elevated levels of serum miR-92a-3p and miR-182-3p were linked to APOs. The AUCs of miR-92a-3p, miR-182-3p, and the combination of the two for predicting APOs were 0.795, 0.775, and 0.845, respectively.</p><p><strong>Conclusion: </strong>miR-92a-3p and miR-182-3p exhibited diagnostic value for GDM and were correlated with APOs in patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"909-916"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}