Irish Journal of Medical Science最新文献_第8页

11 Abstracts from UL Hospitals NCHD Conference. UL医院NCHD会议摘要11篇。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 DOI: 10.1007/s11845-025-03911-w

引用次数: 0

The relationship between fatigue levels and psychosocial adjustment in elderly individuals with chronic obstructive pulmonary disease: A descriptive study. 患有慢性阻塞性肺病的老年人的疲劳程度与社会心理适应之间的关系：一项描述性研究。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-01-28 DOI: 10.1007/s11845-025-03882-y

Ebru Akbaş, Sümeyra Buse Filikci

{"title":"The relationship between fatigue levels and psychosocial adjustment in elderly individuals with chronic obstructive pulmonary disease: A descriptive study.","authors":"Ebru Akbaş, Sümeyra Buse Filikci","doi":"10.1007/s11845-025-03882-y","DOIUrl":"10.1007/s11845-025-03882-y","url":null,"abstract":"Background: Chronic Obstructive Pulmonary Disease (COPD) is associated with physical limitations and significant social, psychological, and behavioral challenges. This study investigates the relationship between fatigue levels and psychosocial adjustment in COPD patients, considering their sociodemographic characteristics.Methods: A descriptive study was conducted with 160 COPD patients hospitalized in the Pulmonology Department of a university hospital. Data were collected via face-to-face interviews using a patient information form, the COPD and Asthma Fatigue Scale (CAFS), and the Psychosocial Adjustment to Illness Scale-Self-Report (PAIS-SR). Statistical analyses included Independent Sample t-test, One-Way ANOVA, Mann-Whitney U test, Kruskal-Wallis test, and Spearman correlation analysis, with significance set at p < 0.05.Results: The mean age of participants was 68.70 ± 9.41 years; 71.9% were male, and 67.9% had COPD for over six years. Most participants (74.4%) reported limitations in daily living activities due to the disease, and 91.9% reported having social support. Mean scores were 58.03 ± 15.80 on the CAFS and 64.19 ± 6.41 on the PAIS-SR. Significant differences were observed in fatigue and psychosocial adjustment scores based on gender, social support, and disease impact on daily activities (p < 0.05). A weak positive correlation was found between fatigue levels and psychosocial adjustment (p < 0.05).Conclusions: COPD patients experience moderate-to-high fatigue levels and challenges in psychosocial adjustment, with fatigue negatively influencing adjustment. Interventions should focus on enhancing coping strategies, addressing psychosocial needs, and leveraging social support systems to improve patient outcomes.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"649-656"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of anti-nuclear antibodies in COVID-19 patients: a remarkable 2.5-fold rise compared to healthy controls. COVID-19患者的抗核抗体患病率：与健康对照组相比，显著上升2.5倍。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-02-01 DOI: 10.1007/s11845-025-03886-8

Faruk Dişli, Sedat Yıldız

{"title":"Prevalence of anti-nuclear antibodies in COVID-19 patients: a remarkable 2.5-fold rise compared to healthy controls.","authors":"Faruk Dişli, Sedat Yıldız","doi":"10.1007/s11845-025-03886-8","DOIUrl":"10.1007/s11845-025-03886-8","url":null,"abstract":"Background: The SARS-CoV-2 virus, responsible for COVID-19, has the potential to induce the formation of antibodies that target self-antigens. This study aimed to investigate the prevalence of antinuclear antibodies (ANA), the most common type of autoantibody, in both healthy individuals and those recovered from COVID-19.Methods: This retrospective study involved 400 participants (200 with COVID-19 and 200 healthy controls), aged 18 to 60 years, without any chronic diseases, including autoimmune conditions. Analyses were performed using three different ANA ELISA test kits (anti-dsDNA, anti-ENA, and anti-Hep-2 nucleus tests) that were developed and validated.Results: Among the 200 healthy individuals, 38 (19%) tested positive for dsDNA, 37 (18.5%) for ENA, and 30 (15%) for Hep-2 nucleus antibodies. The rates of ANA positivity were significantly higher in individuals with COVID-19, with 97 (48.5%) positive for dsDNA, 81 (40.5%) for ENA, and 84 (42%) for Hep-2 nucleus antibodies (p < 0.05).Conclusion: One in every two to three individuals with COVID-19 exhibited ANA positivity, indicating that the SARS-CoV-2 virus poses a significant risk regarding autoimmunity. Furthermore, the incidence of ANA in healthy individuals was observed to be higher than the literature average.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"717-724"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of surgical necessity in children with ureteropelvic junction obstruction using machine learning. 利用机器学习预测输尿管盆腔交界处梗阻儿童的手术必要性。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1007/s11845-025-03895-7

Çiğdem Arslan Alici, Baran Tokar

{"title":"Prediction of surgical necessity in children with ureteropelvic junction obstruction using machine learning.","authors":"Çiğdem Arslan Alici, Baran Tokar","doi":"10.1007/s11845-025-03895-7","DOIUrl":"10.1007/s11845-025-03895-7","url":null,"abstract":"Background: Hydronephrosis developing at the ureteropelvic junction due to obstruction poses clinical challenges as it has the potential to cause renal damage.Aims: This study aims to evaluate how well machine learning models such, as XGBClassifier and Logistic Regression can be used to predict the need for treatment in patients, with hydronephrosis resulting from ureteropelvic junction obstruction.Methods: Hydronephrosis was diagnosed in the medical records of patients from January 2015 to December 2020. These patients were classified into two groups: those who were not operated upon (n = 194) and those who had surgical procedures (n = 129). Details such as demographics, clinical presentations, and imaging findings were captured. XGBClassifier and Logistic Regression methods were employed to predict the requirement for an operation. The performance of the models was assessed based on ROC-AUC values, sensitivity, and specificity.Results: The XGBClassifier algorithm gave the best prediction results with a ROC-AUC value of 0.977 and an accuracy rate of 95.4%. The Logistic Regression algorithm, on the other hand, offered the highest prediction during cross-validation. The presence of obstruction on scintigraphy, kidney size, anteroposterior diameter of the renal pelvic and parenchymal thickness observed in hydronephrotic kidney on USG have been identified as important predictive factors.Conclusions: In predicting the requirement for surgery in cases of hydronephrosis due to obstruction, machine learning algorithms have shown high accuracy and sensitivity rates. Consequently, clinical decision support systems based on these algorithms may lead to better care management of patients and more accurate projections concerning the need for surgical intervention.Trial registration number and date of registration: ESH/GOEK 2024/88-23/01/2024.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"583-590"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The triglyceride-glucose index as a surrogate measure to assess glycemic control in type 2 diabetes patients. 甘油三酯-葡萄糖指数作为评估2型糖尿病患者血糖控制的替代指标。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1007/s11845-025-03893-9

Luis E Simental-Mendía, Francisco G Morales-Gurrola, Laura Jazel Barragán-Zúñiga

{"title":"The triglyceride-glucose index as a surrogate measure to assess glycemic control in type 2 diabetes patients.","authors":"Luis E Simental-Mendía, Francisco G Morales-Gurrola, Laura Jazel Barragán-Zúñiga","doi":"10.1007/s11845-025-03893-9","DOIUrl":"10.1007/s11845-025-03893-9","url":null,"abstract":"Background: It has been revealed that the potential utility of the triglycerides and glucose (TyG) index as an effective option for assessing glycemic control; however, evidence in this field is still scarce.Aims: The goal of this study was to investigate the diagnostic accuracy of the TyG index, as an alternative option, to detect inadequate glycemic control in patients with type 2 diabetes (T2D).Methods: Men and women between 30 and 60 years of age diagnosed with type 2 diabetes were included in a cross-sectional study. Exclusion criteria were smoking, alcohol intake, pregnancy, type 1 diabetes, cancer, autoimmune diseases, active infections, kidney disease, and incomplete data. According to the glycated hemoglobin (HbA1c) concentration, patients were allocated into the groups with optimal (< 7.0%) and deficient (≥ 7.0%) glycemic control.Results: In total, 129 patients aged 51.1 ± 6.6 years were included in this study. The logistic regression analysis adjusted by age, sex, body mass index, waist circumference, and time of diabetes diagnosis revealed that the TyG index is strongly associated with deficient glycemic control (OR = 86.6; 95% CI: 12.9 - 576.9). The best cut-off point of the TyG index for identifying inadequate glucose control was 4.93, which showed the highest sensitivity (80%) and specificity (67%) values. Additionally, the positive and negative predictive values were 71% and 74%, while the positive and negative likelihood ratios were 1.68 and 0.41, respectively.Conclusion: The results of our study suggest that the TyG index may be used as an optional test for assessing glycemic control in patients with T2D.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"515-520"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burnout, wearing thin, and the courage to walk away. 精疲力竭，日渐消瘦，并鼓起勇气走开。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1007/s11845-025-03901-y

Frank Houghton

引用次数: 0

Effects of different hemispheric gliomas on depression and prognosis in neurosurgery patients. 不同半球胶质瘤对神经外科患者抑郁及预后的影响。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1007/s11845-025-03912-9

Kun Zhao, Jiakun Xu, Jiayu Gu, Beichuan Zhao

{"title":"Effects of different hemispheric gliomas on depression and prognosis in neurosurgery patients.","authors":"Kun Zhao, Jiakun Xu, Jiayu Gu, Beichuan Zhao","doi":"10.1007/s11845-025-03912-9","DOIUrl":"10.1007/s11845-025-03912-9","url":null,"abstract":"Background: Depression is common in patients with gliomas, but few studies focused on the association between depression and glioma laterality.Aims: This study was purposed to investigate depression difference and prognostic value between patients with left-hemispheric gliomas and right-hemispheric gliomas.Methods: This study included 212 patients with left-hemispheric gliomas and 218 patients with right-hemispheric gliomas. Hospital Anxiety and Depression Scale (HADS) and Zung self-rating depression scale (SDS) were independently performed before surgery, 3 months and 6 months after surgery. All patients were followed up to death or 36 months. Overall survival (OS) and progression-free survival (PFS) were performed to evaluate the survival of glioma patients.Results: The preoperative prevalence and scores of depression in patients with left-hemispheric gliomas were higher than those in patients with right-hemispheric gliomas. But there were no differences in postoperative prevalence and scores of depression between patients with left-hemispheric gliomas and right-hemispheric gliomas. In patients with left-hemispheric gliomas or with right-hemispheric gliomas, the preoperative scores of depression were higher than postoperative scores of depression, whereas there was no difference in depression score between 3 months after surgery and 6 months after surgery. In addition, patients with right-hemispheric gliomas had better PFS and OS than patients with left-hemispheric gliomas.Conclusions: Patients with left-hemispheric gliomas are more likely to bring about depression than patients with right-hemispheric gliomas. Besides, patients with right-hemispheric gliomas are more likely to have better survival than patients with left-hemispheric gliomas. Surgery is considered as a useful treatment to alleviate depression of glioma patients.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"463-473"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic screening in cohort of Egyptian patients with pulmonary arterial hypertension disease. 埃及肺动脉高压患者队列的遗传筛查。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI: 10.1007/s11845-025-03889-5

Samar I E Ayyad, Miral M Refeat, Engy A Ashaat, Abdel-Rahman B Abdel-Ghaffar, Germine M Hamdy

{"title":"Genetic screening in cohort of Egyptian patients with pulmonary arterial hypertension disease.","authors":"Samar I E Ayyad, Miral M Refeat, Engy A Ashaat, Abdel-Rahman B Abdel-Ghaffar, Germine M Hamdy","doi":"10.1007/s11845-025-03889-5","DOIUrl":"10.1007/s11845-025-03889-5","url":null,"abstract":"Background: Variants in the bone morphogenetic protein 2 receptor gene (BMPR2) are the most frequent genetic cause of pulmonary arterial hypertension (PAH). However, correlation of BMPR2 variants and PAH clinical phenotype remains to be elucidated.Methods and results: The goal of the present study is to investigate variants of the causative gene (BMPR2) in 25 Egyptian patients clinically pre-diagnosed with PAH symptoms and 10 healthy candidates using Sanger sequencing technique. Three pathogenic heterozygous missense variants have been illustrated in BMPR2 gene, two novel variants (V387E, E481K) in exon 9 and 11 respectively and one previously reported missense variant (C496G) in exon 11. The remaining 22 patients as well as the 10 healthy individuals showed no pathogenic variants.Conclusion: Further studies on larger number of participants, using advanced NGS technique, should be performed to enrich information about genotype/phenotype correlations and incidence of PAH disease among Egyptian population; thus, it would provide families of PAH patients with accurate genetic counseling in order to prevent disease recurrence.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"641-648"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluoroquinolones and tendon injury: a 5-year review of Irish national incident and claims data. 氟喹诺酮类药物和肌腱损伤：爱尔兰国家事件和索赔数据的5年回顾。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1007/s11845-025-03913-8

Mark McCullagh, Natasha Coen, Cathal O'Keeffe

{"title":"Fluoroquinolones and tendon injury: a 5-year review of Irish national incident and claims data.","authors":"Mark McCullagh, Natasha Coen, Cathal O'Keeffe","doi":"10.1007/s11845-025-03913-8","DOIUrl":"10.1007/s11845-025-03913-8","url":null,"abstract":"Background/aim: In 2018, the European Medicines Agency strengthened warnings in relation to fluoroquinolone (FQ)-associated tendon injury. There is a lack of published data on FQs and tendon injury in an Irish context. The aim of the study was to investigate incidents and claims relating to FQs and tendon injury through an analysis of National Incident Management System (NIMS) data.Methods: The NIMS database was searched for incidents created between 1st June 2018 and 31st May 2023 which involved any FQ and referenced tendon injury. The incident data was analysed under predetermined field headings. NIMS was also searched for clinical claims involving any FQ with a Claim Finalised Date between 1st June 2018 and 31st May 2023. The claims were analysed to identify common themes.Results: The study identified 20 incidents which related to FQs and tendon injury, although only six reported an actual tendon injury. In 15 (75%) of the incidents, the prescription of a FQ was deemed inappropriate by the reporter. The study found four finalised claims, all of which related to bilateral Achilles tendon rupture following FQ exposure. In all four cases, the patient was aged over 60 and the injury occurred within days of commencing treatment.Conclusions: This study confirms that FQs continue to be prescribed inappropriately in high-risk patients and that incidents of tendon injury following FQ exposure continue to occur despite regulatory moves of raise awareness of this issue. Additional measures to minimise the risk of avoidable patient harm may be warranted.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"757-760"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of shearing wave elastography in detecting early diabetic nephropathy. 剪切波弹性成像在早期糖尿病肾病检测中的作用。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1007/s11845-025-03897-5

Amr M Shaker, Shaza Y Sleem, Mayssa I Aly, Asmaa H Habib, Mona G Hassan

{"title":"Role of shearing wave elastography in detecting early diabetic nephropathy.","authors":"Amr M Shaker, Shaza Y Sleem, Mayssa I Aly, Asmaa H Habib, Mona G Hassan","doi":"10.1007/s11845-025-03897-5","DOIUrl":"10.1007/s11845-025-03897-5","url":null,"abstract":"Background: Diabetes mellitus is one of the systemic diseases affecting the kidneys that eventually develop end-stage kidney disease. Shear wave elastography (SWE) is a reliable and non-invasive ultrasonography test used to determine tissue elasticity. The aim of this study is to detect early diabetic nephropathy by measuring renal stiffness using shear wave elastography (SWE), renal resistivity indices, and laboratory findings in DN patients.Methods: Shear wave elastography and color duplex sonography assessments were performed in 60 diabetic nephropathy patients (divided according to eGFR into 3 stages: stage I-II-III diabetic nephropathy with equal groups of 20 patients in each stage) and 20 healthy age-matched control subjects. The SWE-derived mean value of the tissue stiffness, given in kilopascals (kPa), was correlated to patients' clinico-laboratory data (serum creatinine and eGFR) and resistive index.Results: There is a statistically significant increase in SWE and RI in the diabetic group than control group and a statistically significant increase in SWE (mean) in CKD stage II and III when compared with CKD stage I, SWE can be used to discriminate between diabetic groups and control group at a cutoff level of > 10.5 (kPa), and also, SWE (mean) can be used to discriminate between CKD stage II and III patients at a cutoff level of > 41 (kPa), with 66.7% sensitivity and 64.9% specificity.Conclusion: Shear wave elastography is a sensitive, non-invasive, and specific diagnostic tool for the detection of diabetic nephropathy and differentiation between different stages of DN.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"529-535"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0