Irish Journal of Medical Science最新文献

{"title":"Robotic surgery utilisation and uptake.","authors":"Michael Devine","doi":"10.1007/s11845-025-03970-z","DOIUrl":"10.1007/s11845-025-03970-z","url":null,"abstract":"","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1125-1126"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connected health in cancer survivorship: Evaluating the usability and utility of the cancer thriving and surviving programme in Ireland.","authors":"Isaiah Gitonga, Deirdre Desmond, Louise Mullen, Dorothy Thomas, Cathleen Osborne, Bernie O'Loughlin, Rebecca Maguire","doi":"10.1007/s11845-025-03931-6","DOIUrl":"10.1007/s11845-025-03931-6","url":null,"abstract":"<p><strong>Background: </strong>Cancer survivorship care has become increasingly complex, with a growing population of people living with and beyond the disease requiring holistic support and follow-up. Connected health (CH) offer a promising solution to enhance care delivery.</p><p><strong>Aim: </strong>This study evaluated the usability and effectiveness of CH, and motivations of participants in the Cancer Thriving and Surviving (CTS) programme in Ireland.</p><p><strong>Methods: </strong>A cross-sectional survey of persons living with and beyond cancer (PLWBC) who completed the CH-delivered CTS was conducted between December 2022 and April 2023. Closed and open-ended questions captured participants experiences and motivations. Telehealth Usability Questionnaire (TUQ) assessed the CH usability. Qualitative content analysis examined recurring themes in participant responses.</p><p><strong>Results: </strong>Forty-four participants who engaged in CTS completed the survey. Participants were predominantly female (88%), diagnosed with breast cancer (76%), and had third-level education or higher (86%). Slightly over one third (36%) were in full time employment. Motivations for engaging in CTS included seeking peer support, psychosocial assistance, and practical self-management tools. Most respondents agreed that the programme improved their psychological wellbeing (90%), quality of life (76%) and helped them take more control of their health (83%). TUQ scores indicated high usability of the CH systems.</p><p><strong>Conclusion: </strong>Findings suggest that the CH-delivered CTS programme effectively benefits PLWBC, improving psychological well-being and quality of life. The high CH system usability and positive user experiences highlight its potential to complement in-person care, supporting the continued development and evaluation of CH systems to enhance cancer survivorship, particularly within Irish digital health initiatives.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"827-838"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating the path: the role of photodynamic therapy in comprehensive periodontal treatment.","authors":"Zahra Al-Timimi","doi":"10.1007/s11845-025-03924-5","DOIUrl":"10.1007/s11845-025-03924-5","url":null,"abstract":"<p><strong>Objectives: </strong>Evaluating photodynamic therapy's efficacy and suitability for treating periodontal disease is the main goal of this review. What are the best conditions for using photodynamic therapy, and how can it improve conventional periodontal treatments?.</p><p><strong>Materials and methods: </strong>A comprehensive literature search has been conducted to identify peer-reviewed research published up until August 2024. This search utilized reputable databases, including PubMed, Scopus, and Google Scholar, ensuring a robust selection of relevant studies. Selected studies were meticulously analyzed to their methodologies, types of photosensitizers employed, light intensity levels applied, as well as the resultant clinical outcomes observed. Additionally, a comparative analysis has been performed between photodynamic therapy and traditional periodontal therapy as documented in numerous clinical studies.</p><p><strong>Results: </strong>Results show that photodynamic therapy considerably lowers the number of microorganisms present in periodontal pockets, which in turn reduces inflammation and improves healing responses. According to studies, photodynamic therapy is an efficient way to break up the biofilms that of harmful bacteria that cause periodontal disease produce.</p><p><strong>Conclusions: </strong>Photodynamic therapy is an intriguing alternative treatment option for periodontal disease. Because photodynamic therapy reduces biofilm resistance, improves blood flow, and promotes healing through anti-inflammatory effects, it may yield better clinical results when used in conjunction with conventional periodontal therapies. More research is required to create consistent guidelines for light dosage and photosensitizer selection in order to maximize therapeutic outcomes.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1083-1096"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A trend analysis of weight gain during the nutritional recovery period of severe acute malnutrition among children.","authors":"Mrunali Rahud, Sambasivan Venkat, Deepika Morale, Ravindra Gurav","doi":"10.1007/s11845-025-03944-1","DOIUrl":"10.1007/s11845-025-03944-1","url":null,"abstract":"<p><strong>Background: </strong>Undernutrition, a significant global health concern, affects children under 5 years old. It encompasses stunting, wasting, and nutritional deficits. In India, 35.5% of children are stunted, 32.1% are underweight, 19.3% are wasted, and 7.7% are severely wasted. Severe acute malnutrition (SAM) is a critical form of undernutrition. Nutritional Rehabilitation Centers (NRCs) provide medical and nutritional assistance to malnourished children, using therapeutic feeding diets like F-75 and F-100. Anthropometric measurements track progress during hospitalization, ensuring effective interventions.</p><p><strong>Aims: </strong>The aim of the study is to determine the rate at which weight gain occurs in children during the nutritional recovery period.</p><p><strong>Methods: </strong>Total enumeration of children admitted to the Nutritional Rehabilitation Center from May 2022 to April 2023 were taken under study, and data was collected from the case records. Descriptive statistics was used to summarize the data. Paired t-test was used for comparison of the mean.</p><p><strong>Results: </strong>Nearly equal proportions of boys (52.6%) and girls (47.4%) were included, with the majority under 24 months old. The mean duration of stay was 14.26 ± 1.75 days. The average total weight gain was 0.87 ± 0.27 kg, with girls gaining slightly more (0.86 ± 0.29 kg) than boys (0.88 ± 0.25 kg). The rate of weight gain was 8.56 ± 3.16 g/kg/day, higher among girls (8.92 ± 2.68) than boys (8.24 ± 3.53). Around 46.7% achieved > 15% target weight gain.</p><p><strong>Conclusion: </strong>The study highlights gender disparities favoring better nutritional recovery among girls and younger children at NRCs, advocating for early interventions to reduce undernutrition morbidity and mortality.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1003-1009"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced diagnostic accuracy of type 1 diabetes mellitus through the combined use of serum β-catenin and HbA1c.","authors":"Baydaa Ahmed Abed, Fatima Khazaal, Noor Ulhuda G Mohammed, Layla Othman Farhan, Isam Noori Salman","doi":"10.1007/s11845-025-03977-6","DOIUrl":"10.1007/s11845-025-03977-6","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes mellitus (T1DM) is due to the autoimmune destruction of pancreatic β-cells. Biomarkers of early diagnosis of T1DM are important to improve treatment and prevent complications. β-catenin, a key effector of the WNT signaling pathway, plays a critical role in the development of pancreatic β-cells. This study investigates the association between serum β-catenin protein and T1DM and evaluates its diagnostic performance compared to routine markers.</p><p><strong>Material and methods: </strong>The study included 50 patients with T1DM aged 15-25 years and 30 healthy age- and gender-matched subjects (HS). All participants were evaluated with full history taking, thorough clinical examination, and laboratory evaluation of biochemical tests and glycemic markers. Serum β-catenin was measured using an enzyme-linked immunosorbent assay.</p><p><strong>Result: </strong>There were significant differences in the concentration of β-catenin between T1DM and HS (P < 0.001). Gender, HbA1c, BU, and lipid profile were found to be significantly independently related to β-catenin levels (P < 0.05). β-catenin showed excellent discriminatory ability (AUC 1.0); the results revealed that the best cut-off value of β-catenin levels to predict T1DM was > 1.81 ng/ml.</p><p><strong>Conclusion: </strong>The results show that the concentration of β-catenin has the potential to diagnose T1DM. Further, larger studies are needed on whether β-catenin has a therapeutic role in T1DM.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"917-921"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of progesterone receptor expression in non-small cell lung cancer tissue.","authors":"Romanov I P, Bogush T A, Scherbakov A M, Grishanina A N, Bogush E A, Ravcheeva A B, Kosorukov V S","doi":"10.1007/s11845-025-03917-4","DOIUrl":"10.1007/s11845-025-03917-4","url":null,"abstract":"<p><strong>Background: </strong>Progesterone receptors (PRs) play a role in the regulation of cell proliferation and are expressed in non-small cell lung cancer (NSCLC) tissue. Therefore, they represent a potential target for novel antitumor therapies. A survival analysis of NSCLC patients based on PR expression in tumor tissue may help assess the feasibility of using PR modulators in the treatment of this disease.</p><p><strong>Aim: </strong>This study aims to evaluate the prognostic significance of PR expression in NSCLC to determine the potential utility of PR modulators as a therapeutic strategy.</p><p><strong>Methods: </strong>PR expression was assessed in 130 surgically resected NSCLC samples using immunofluorescence analysis combined with flow cytometry. Primary antibodies against PR (NBP2-4638, Novus Biologicals, USA) and secondary antibodies conjugated with DyLight650 (ab98729, Abcam, UK) were used. The percentage of PR-expressing cells was quantified using FlowJo software. Statistical analyses were conducted in GraphPad Prism and RStudio using the \"survival\" package. The prognostic impact of PR expression in NSCLC tissue was evaluated in the overall patient cohort and after excluding censored events (n = 56) to minimize the influence of confounding factors on survival analysis.</p><p><strong>Results: </strong>After excluding censored events and stratifying patients based on the median PR expression level (57%), survival analysis revealed that high PR expression in NSCLC tissue is associated with a poorer prognosis (p = 0.05). Patients with high PR expression (≥ 57%) had a median survival of 12.8 months, whereas those with low PR expression (< 57%) had a median survival of 25.8 months (HR = 1.7).</p><p><strong>Conclusions: </strong>Elevated PR expression in NSCLC tumors is associated with reduced patient survival. These findings suggest that PR modulators may have potential therapeutic value for NSCLC patients with PR-positive tumors.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"817-825"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of machine learning models in a resource-constrained environment.","authors":"Addison M Heffernan, Jaewook Shin, Kemunto Otoki, Robert K Parker, Daithi S Heffernan","doi":"10.1007/s11845-025-03951-2","DOIUrl":"10.1007/s11845-025-03951-2","url":null,"abstract":"<p><strong>Background: </strong>Machine learning models (MLMs) used to influence surgical decision making often require large and complex datasets upon which to train. However, there is a paucity of literature pertaining to the ability to apply standard MLMs to small ICU datasets within resource-constrained institutions.</p><p><strong>Methods: </strong>ML models were applied to a prospective cohort of critically ill mechanically ventilated patients from a teaching hospital in rural Kenya. Characteristics included an ICU scoring system specifically for resource-constrained environments (Tropical Intensive Care Score (TropICS)). Outputs included AUC of the ROC and the feature importance table. Python-based MLMs included XGBoost and KNN. AUC of the ROC was calculated to predict mortality as the primary endpoint.</p><p><strong>Results: </strong>There were 294 patients, with an average age of 40.2 years, 64.3% male, 23.8% trauma, and an overall mortality of 60.2%. With respect to mortality patients who died were older (43.5 versus 35 years; p < 0.001), but with no difference in male gender (64.8% versus 63.8%; p = 0.9), or having been transferred from outside facilities (34% versus 21.5%; p = 0.5). Whilst there was no difference in the rate of tachycardia or acidosis, patients who died were more likely to present with hemodynamic instability (31% versus 6%; p < 0.001) and higher clinical severity scores. In predicting mortality, the ML models performed very well (XGBoost AUC = 0.82). Within MLM feature importance, the Tropical Intensive Care Score (TropICS) performed as well as APACHE-II and the SAPS.</p><p><strong>Conclusion: </strong>ML models can be effectively applied to a small ICU dataset within resource-constrained environments. ML models must demonstrate functionality prior to incorporating within prospective clinical predictive models. Contextualized ICU scoring systems (TropICS) performed well within MLMs.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1117-1124"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment to: \"Treatment of a STAT5b::RARα positive case of APL in a patient not eligible for intensive chemotherapy\".","authors":"Zhan Su, Yujie Xu, Shanshan Liu, Tianlan Li, Xianqi Feng","doi":"10.1007/s11845-025-03958-9","DOIUrl":"10.1007/s11845-025-03958-9","url":null,"abstract":"","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1017-1019"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valid consent in the acute hospital setting: perspectives of nursing and medical professionals from a survey-based study.","authors":"Charmaine Zahra, Motheo Kobua, Živa Kovic, Mary Fogarty, Catherine Buckley, Jane Murphy, Julie Walshe, Paul Zambra, Declan Byrne, Una Geary, Marie E Ward","doi":"10.1007/s11845-025-03952-1","DOIUrl":"10.1007/s11845-025-03952-1","url":null,"abstract":"<p><strong>Background: </strong>In healthcare, consent refers to the act of granting permission or agreement for treatment and care, investigation, receiving or utilising a service, or participating in research or teaching. Consent should be an ongoing process that involves clear communication about the proposed intervention, including its nature, benefits, and potential risks.</p><p><strong>Aim: </strong>This survey-based study gathered experiences from junior doctors and nurses in a large acute teaching hospital about current consent practices and suggestions for improvement.</p><p><strong>Method: </strong>Two surveys were developed and distributed to junior doctors in 2022 and nurses in 2023.</p><p><strong>Results: </strong>The response rate for junior doctors (n = 58) was 21% (interns) and 57% (senior house officers) and 10% of the total nursing population responded (n = 184). Descriptive statistics and content analysis were used to analyse the results. Both junior doctors and nursing professionals believed there were areas for improvement in terms of consent processes and practices including in relation to better information for patients and more education and training for healthcare professionals.</p><p><strong>Conclusions: </strong>The process of informed consent is central in the planning and provision of safe, effective person-centred healthcare as it encompasses healthcare professionals and patients communicating about and together deciding on and agreeing to medical interventions. This survey-based study looked at the experiences, attitudes, and perceived needs of junior doctors and nursing professionals in relation to the informed consent process in clinical practice at an acute hospital and informed the development of recommendations for improvement.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"775-791"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of COVID-19 during pregnancy on postpartum depression and mother-infant attachment.","authors":"Canan Satır Özel, Reyhan Ayaz Bilir, Evrim Şenkal, Tahsin Gökhan Telatar, Abdulkadir Turgut","doi":"10.1007/s11845-025-03928-1","DOIUrl":"10.1007/s11845-025-03928-1","url":null,"abstract":"<p><strong>Background: </strong>The psychiatric impacts of the COVID-19 pandemic are well-documented; however, its effects during the postnatal period have been less explored.</p><p><strong>Aims: </strong>We aimed to investigate the effect of COVID-19 on mother-infant attachment and postnatal depression in pregnant women during the pandemic.</p><p><strong>Methods: </strong>The study group consisted of women with the diagnosis of 'pregnancy and COVID-19' after the 20th gestational week (n = 55). The control group included women who did not have a history of COVID-19 in their pregnancy or until the study date (n = 52). Edinburgh Postpartum Depression Scale (EPDS) and Postpartum Attachment Scale (PPAS) were administered to the participants. COVID-19 patients were grouped according to the WHO classification.</p><p><strong>Results: </strong>The mean EPDS score was higher in the study group than in the control group (9.55 (7.17) vs. 6.65 (6.72) (P = 0.006)). There was no difference between the groups in the number of individuals with depression (EPDS score > 13) and PPAS factors. The mean EPDS score was found to be higher in the hospitalized group (P = 0.025). The mean EPDS score in the group with moderate or severe disease was higher than mild disease group (16 (8.49) vs. 8.67 (6.57) (P = 0.039)), there was no difference in terms of PPAS.</p><p><strong>Conclusion: </strong>While the presence of COVID-19 during pregnancy has been associated with elevated postpartum depression scores in pandemic pregnant women, hospitalization of women who had COVID-19 during pregnancy and had at least one family member with moderate or more severe illness resulted in higher depression scores. The presence of COVID-19 during pregnancy does not affect mother-infant attachment. It is recommended that women with a history of COVID-19 during pregnancy be evaluated more carefully for postpartum depression.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"1039-1048"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}