Irish Journal of Medical Science最新文献

{"title":"Combination therapy with vitamin E and ertugliflozin in patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus: a randomized clinical trial.","authors":"Adil Khaliq, Haroon Badshah, Yasar Shah","doi":"10.1007/s11845-025-03945-0","DOIUrl":"https://doi.org/10.1007/s11845-025-03945-0","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity in type 2 diabetes mellitus (T2DM), with shared pathophysiological mechanisms, including insulin resistance, oxidative stress, and inflammation.</p><p><strong>Objectives: </strong>This study evaluates the effects of vitamin E and ertugliflozin, individually and in combination, alongside standard pioglitazone therapy, on hepatic and metabolic parameters in patients with NAFLD and T2DM.</p><p><strong>Methods: </strong>A 24-week, double-blind, randomized, controlled clinical trial on 173 patients with NAFLD and T2DM was assigned into four groups: vitamin E (n = 42), pioglitazone (n = 43), ertugliflozin (n = 44), and vitamin E + ertugliflozin (n = 44) combination therapy. The primary outcome was to monitor changes in liver steatosis assessed via ultrasound. Secondary outcomes included evaluation of liver enzymes, glycemic control, fibrosis markers, and lipid profiles.</p><p><strong>Results: </strong>Combination therapy of vitamin E + ertugliflozin showed the highest decrease in liver fat content, with 11 participants achieving successful Grade 0 (p < 0.001). Significant improvements were also observed in glycemic control, HbA1c, triglycerides, and liver enzymes. Ertugliflozin monotherapy showed significant efficacy in improving liver enzymes, glycemic parameters, and fibrosis markers. Pioglitazone improved the initial stage of NAFLD but had a limited impact on advanced fibrosis. Ertugliflozin, in combination with vitamin E, decreases oxidative stress; however, vitamin E by itself has no impact on the metabolic and fibrosis index.</p><p><strong>Conclusion: </strong>The ertugliflozin and vitamin E combination is a very effective treatment for patients with NAFLD and T2DM. It improves hepatic steatosis and metabolic indicators. Exploration is required for combination therapy in order to assess the prolonged efficacy and safety of the treatment.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"11 Abstracts from UL Hospitals NCHD Conference.","authors":"","doi":"10.1007/s11845-025-03911-w","DOIUrl":"https://doi.org/10.1007/s11845-025-03911-w","url":null,"abstract":"","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A trend analysis of weight gain during the nutritional recovery period of severe acute malnutrition among children.","authors":"Mrunali Rahud, Sambasivan Venkat, Deepika Morale, Ravindra Gurav","doi":"10.1007/s11845-025-03944-1","DOIUrl":"https://doi.org/10.1007/s11845-025-03944-1","url":null,"abstract":"<p><strong>Background: </strong>Undernutrition, a significant global health concern, affects children under 5 years old. It encompasses stunting, wasting, and nutritional deficits. In India, 35.5% of children are stunted, 32.1% are underweight, 19.3% are wasted, and 7.7% are severely wasted. Severe acute malnutrition (SAM) is a critical form of undernutrition. Nutritional Rehabilitation Centers (NRCs) provide medical and nutritional assistance to malnourished children, using therapeutic feeding diets like F-75 and F-100. Anthropometric measurements track progress during hospitalization, ensuring effective interventions.</p><p><strong>Aims: </strong>The aim of the study is to determine the rate at which weight gain occurs in children during the nutritional recovery period.</p><p><strong>Methods: </strong>Total enumeration of children admitted to the Nutritional Rehabilitation Center from May 2022 to April 2023 were taken under study, and data was collected from the case records. Descriptive statistics was used to summarize the data. Paired t-test was used for comparison of the mean.</p><p><strong>Results: </strong>Nearly equal proportions of boys (52.6%) and girls (47.4%) were included, with the majority under 24 months old. The mean duration of stay was 14.26 ± 1.75 days. The average total weight gain was 0.87 ± 0.27 kg, with girls gaining slightly more (0.86 ± 0.29 kg) than boys (0.88 ± 0.25 kg). The rate of weight gain was 8.56 ± 3.16 g/kg/day, higher among girls (8.92 ± 2.68) than boys (8.24 ± 3.53). Around 46.7% achieved > 15% target weight gain.</p><p><strong>Conclusion: </strong>The study highlights gender disparities favoring better nutritional recovery among girls and younger children at NRCs, advocating for early interventions to reduce undernutrition morbidity and mortality.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of stress and earthquake-related trauma on fibromyalgia: a longitudinal study.","authors":"Muhammed Aslan, Irada Ibramkhalilova, Melis Mutlu, Fatih Albayrak, Pinar Gunel, Bunyamin Kisacik","doi":"10.1007/s11845-025-03955-y","DOIUrl":"https://doi.org/10.1007/s11845-025-03955-y","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia (FM) is a chronic disorder characterized by widespread pain, fatigue, and psychological symptoms. While psychological trauma is known to affect FM severity, the impact of natural disasters, such as earthquakes, remains insufficiently studied.</p><p><strong>Aim: </strong>This study aimed to evaluate the effects of earthquake-related trauma on fibromyalgia severity and quality of life.</p><p><strong>Methods: </strong>A total of 100 patients diagnosed with fibromyalgia per the American College of Rheumatology 2016 criteria were enrolled. All participants experienced the February 2023 earthquakes in Turkey. Disease activity and quality of life were assessed using the Fibromyalgia Impact Questionnaire (FIQ) at 1 and 6 months post-earthquake. The Impact of Event Scale-Revised (IES-R) was employed to measure psychological trauma levels. Statistical analyses included paired t-tests and Pearson's correlation coefficients.</p><p><strong>Results: </strong>FIQ scores significantly improved from 1 month (74.97 ± 20.15) to 6 months (67.25 ± 16.39) post-earthquake (p < 0.001). A strong positive correlation was found between IES-R and FIQ scores at 1 month (r = 0.636, p < 0.01) and 6 months (r = 0.411, p < 0.01). Subgroups with home or family loss showed more pronounced FIQ scores, while groups exposed to new stress factors did not show significant changes over time (p = 0.307).</p><p><strong>Conclusions: </strong>This study demonstrates that earthquake-related trauma exacerbates fibromyalgia symptoms, highlighting the necessity of integrating psychological and stress management interventions in the treatment of FM, particularly in disaster-affected regions.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing chronic low back pain: investigating the role of Pilates in subacute management-a randomized controlled trial.","authors":"Hatice Kubra Asik, Tugba Sahbaz","doi":"10.1007/s11845-025-03939-y","DOIUrl":"https://doi.org/10.1007/s11845-025-03939-y","url":null,"abstract":"<p><strong>Background: </strong>Subacute low back pain (LBP) is a critical phase that can determine long-term patient outcomes. Exercise therapy, including Pilates, is widely used to manage LBP, but its effectiveness in the subacute phase remains underexplored. This randomized controlled trial aims to compare the effects of an 8-week Pilates-based intervention versus a home exercise program on pain intensity, functional disability, and quality of life in patients with subacute LBP.</p><p><strong>Methods: </strong>Sixty-six participants with subacute LBP were randomized into two groups: a supervised Pilates group and a home exercise group. Pain intensity (Visual Analog Scale), functional disability (Roland-Morris Disability Questionnaire), and quality of life (Short Form-36) were assessed at baseline, post-intervention, and 3-month follow-up.</p><p><strong>Results: </strong>Both groups exhibited significant improvements in all outcome measures (p < 0.001). However, the Pilates group showed superior reductions in pain intensity (p = 0.010 post-treatment, p = 0.002 at follow-up) and functional disability (p = 0.009 and p = 0.002). Additionally, quality of life scores improved more significantly in the Pilates group, particularly in physical function (p = 0.031 and p = 0.025) and general health (p = 0.005 and p = 0.012).</p><p><strong>Conclusions: </strong>Pilates-based rehabilitation was more effective than a home exercise program in improving pain, disability, and quality of life in patients with subacute LBP. These findings support the inclusion of Pilates in early-stage rehabilitation to prevent chronicity.</p><p><strong>Trial registration: </strong>Clinical Trials Number: NCT06699511.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of machine learning models in a resource-constrained environment.","authors":"Addison M Heffernan, Jaewook Shin, Kemunto Otoki, Robert K Parker, Daithi S Heffernan","doi":"10.1007/s11845-025-03951-2","DOIUrl":"https://doi.org/10.1007/s11845-025-03951-2","url":null,"abstract":"<p><strong>Background: </strong>Machine learning models (MLMs) used to influence surgical decision making often require large and complex datasets upon which to train. However, there is a paucity of literature pertaining to the ability to apply standard MLMs to small ICU datasets within resource-constrained institutions.</p><p><strong>Methods: </strong>ML models were applied to a prospective cohort of critically ill mechanically ventilated patients from a teaching hospital in rural Kenya. Characteristics included an ICU scoring system specifically for resource-constrained environments (Tropical Intensive Care Score (TropICS)). Outputs included AUC of the ROC and the feature importance table. Python-based MLMs included XGBoost and KNN. AUC of the ROC was calculated to predict mortality as the primary endpoint.</p><p><strong>Results: </strong>There were 294 patients, with an average age of 40.2 years, 64.3% male, 23.8% trauma, and an overall mortality of 60.2%. With respect to mortality patients who died were older (43.5 versus 35 years; p < 0.001), but with no difference in male gender (64.8% versus 63.8%; p = 0.9), or having been transferred from outside facilities (34% versus 21.5%; p = 0.5). Whilst there was no difference in the rate of tachycardia or acidosis, patients who died were more likely to present with hemodynamic instability (31% versus 6%; p < 0.001) and higher clinical severity scores. In predicting mortality, the ML models performed very well (XGBoost AUC = 0.82). Within MLM feature importance, the Tropical Intensive Care Score (TropICS) performed as well as APACHE-II and the SAPS.</p><p><strong>Conclusion: </strong>ML models can be effectively applied to a small ICU dataset within resource-constrained environments. ML models must demonstrate functionality prior to incorporating within prospective clinical predictive models. Contextualized ICU scoring systems (TropICS) performed well within MLMs.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of prusogliptin in type-2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.","authors":"Abdul Moeed, Muhammad Ahmed Ali Fahim, Afia Salman, Tooba Saqib, Laiba Zafar, Hoorain Jamil, Alishba Adnan Janjua, Syed Muhammad Muneeb Akhtar, Hamna Ahmed Khan, Hajra Zainab Chaudry, Ayesha Ali, Laiba Sanober, Muqaddas Parvez, Hala Najeeb, Abdul Hannan Siddiqui, Salim Surani","doi":"10.1007/s11845-025-03948-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03948-x","url":null,"abstract":"<p><strong>Background: </strong>This study aims to conduct a systematic review and meta-analysis of the currently present literature analyzing the effectiveness and safety profile of prusogliptin, a novel dipeptidyl peptidase-IV (DPP-4) inhibitor, as compared to placebo in type 2 diabetes mellitus (T2DM) patients.</p><p><strong>Methods: </strong>This systemic review and meta-analysis complied with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search strategy based on various MeSH terms was run on: PubMed/Medline, SCOPUS, and Cochrane Central, which were then systematically searched from inception till March 2024 to select all relevant Randomized Control Trials (RCT).</p><p><strong>Results: </strong>The analysis of the findings from three RCTs with 957 patients revealed that prusogliptin reduced Hemoglobin A1c (HbA1c)% levels in T2DM patients significantly [Mean Difference (MD): -0.62, 95% Confidence Interval (CI): -0.74 to -0.50, I² = 0%, p < 0.001] and led to more patients with a HbA1c% ≤ 7% [Odds Ratio (OR): 2.65, 95%CI: 1.94 to 3.61, I² = 0%, p < 0.00001]. However, prusogliptin led to a non-significant increase in weight when compared with placebo (MD: 0.22, 95% CI: -0.50 to 0.93, I² = 60%, p = 0.551). The safety profile of prusogliptin revealed a non-significant decrease in treatment-emergent adverse events (OR: 0.90, 95% CI: 0.59 to 1.38, I² = 43%, p = 0.64) and a non-significant increase in treatment-emergent serious adverse events (OR: 1.02, 95% CI: 0.43 to 2.44, I² = 0%, p = 0.96) and drug-related adverse events (OR: 1.07, 95%CI: 0.68 to 1.69, I² = 0%, p = 0.76).</p><p><strong>Conclusion: </strong>Prusogliptin has a favorable efficacy in attaining glycemic control in patients with T2DM. However, its safety profile yields uncertain outcomes. More literature is required for a definitive result.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term health consequences of COVID-19 in young adults: a focus on respiratory and cardiovascular endurance.","authors":"Manohara H G, Megha Bhat Agni, Damodara Gowda K M","doi":"10.1007/s11845-025-03950-3","DOIUrl":"https://doi.org/10.1007/s11845-025-03950-3","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has significantly impacted health, extending beyond the acute phase of illness. Among young adults, \"long COVID\" has raised concerns regarding respiratory and cardiovascular endurance. This study evaluates pulmonary function test (PFT), distance travelled in the 6-min walk test (6MWT), and changes in SpO2 and respiratory rate before and after 6MWT in COVID-19 convalescent patients compared to healthy controls.</p><p><strong>Methods: </strong>This case-control study included 45 controls and 45 COVID-19 convalescent patients confirmed by RT-PCR. Data on PFT, distance travelled in 6MWT, SpO2, and respiratory rate were collected. The associations were analyzed using the Student t-test and ANOVA, with p < 0.05 considered significant.</p><p><strong>Results: </strong>Significant reductions were observed in FVC (p = 0.02), FEV₁ (p = 0.007), FEF_25% (p = 0.0001), FEF_50% (p = 0.003), FEF_25-75% (p = 0.02), and PEFR (p = 0.0001), with an increased lung age (p = 0.01) in COVID-19 convalescent patients compared to controls. No significant difference was observed in FEV₁/FVC ratio, FEV₃, FEV₃/FVC ratio, or FEF_75%. While percentage saturation of oxygen, respiratory rate, and distance travelled in 6MWT showed no significant differences between groups, respiratory rate (p = 0.0001) and pulse rate (p = 0.001) differed significantly before and after 6MWT.</p><p><strong>Conclusions: </strong>COVID-19 convalescent patients exhibited significant declines in FVC, FEV₁, FEF_25%, FEF_50%, and FEF_25-75%, indicating potential restrictive or obstructive lung defects. Increased lung age also suggests long-term impacts of SARS-CoV-2 on respiratory performance.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Klotho protein level in patients with thyroid dysfunction.","authors":"Noor Abd Al-Hakeem Abdullah, Ekhlas Abdallah Hassan","doi":"10.1007/s11845-025-03937-0","DOIUrl":"https://doi.org/10.1007/s11845-025-03937-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study focused on determining the new marker Klotho and its correlation with other parameters in thyroid dysfunction.</p><p><strong>Methods: </strong>Seventy-seven thyroid dysfunction patients were recruited during the period (from Aug 2024 to Dec 2024) with an age range (33-56) years. The patient group was subdivided into two groups: group I (21) Patients with Hyperthyroidism and group II (56) Patients with Hypothyroidism, for comparison, 30 healthy individuals were included as a control. The protein level Klotho was estimated using ELISA. Biochemical parameters; blood urea, creatinine, and lipid profile were measured spectrophotometrically. T3, T4 and TSH were determined using ELFA kit.</p><p><strong>Results: </strong>Serum levels of Klotho protein were significantly lower (p-value < 0.001) in group I compared to the control group. There was a significant difference (p < 0.001) in the Klotho protein levels in group II compared with the control group. Klotho protein was negatively correlated to TSH, creatinine concentrations, and age. The AUC was excellent with high diagnostic accuracy in differentiating newly diagnosed thyroid dysfunction from the healthy subject group.</p><p><strong>Conclusions: </strong>Serum Klotho levels in patients with thyroid dysfunction significantly decreased, particularly in hypothyroidism patients. These levels are inversely correlated with thyroid-stimulating hormone levels and age.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between hand grip and pinch strength, body composition, pain threshold, and anxiety in dentists.","authors":"Sena Gizem Arslan, Abdurrahim Yildiz, Birgul Dingirdan Gultekinler","doi":"10.1007/s11845-025-03941-4","DOIUrl":"https://doi.org/10.1007/s11845-025-03941-4","url":null,"abstract":"<p><strong>Background: </strong>Work-related musculoskeletal disorders are commonly observed across various occupational groups.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the relationships between hand grip and pinch strength, body composition, pain threshold, and anxiety levels in dentists.</p><p><strong>Methods: </strong>The study included 49 dentists working at Sakarya Oral and Dental Health Hospital. Participants' grip strength, including pinch and gross grip, was assessed using the Jamar hand dynamometer, while the muscle strength of the forearm flexor and extensor muscles was measured with a handheld dynamometer. Anxiety levels were evaluated using the Beck Anxiety Inventory, and pain threshold was assessed using an algometer.</p><p><strong>Results: </strong>A positive and significant correlation was found between body mass index (BMI) and dominant and non-dominant hand grip strength (r = 0.485, p = 0.003; r = 0.501, p = 0.002). BMI also showed a strong relationship with dominant and non-dominant finger strength (r = 0.511, p < 0.001; r = 0.557, p < 0.001). A negative correlation was found between Beck Anxiety Score and physical strength parameters, especially non-dominant hand grip strength (r = 0.619, p = 0.005) and dominant hand grip strength (r =  - 0.512, p = 0.025) and anxiety levels. Significant positive correlations were found between pain threshold and physical strength parameters, especially non-dominant wrist extensor strength (r = 0.283, p = 0.049) and dominant hand grip strength (r = 0.408, p = 0.015) which were found to increase pain threshold.</p><p><strong>Conclusions: </strong>Physical and psychological factors have an impact on occupational performance, especially in occupations that require prolonged use of the hands and wrists, such as dentistry.</p><p><strong>Trial registration: </strong>This study is prospectively registered at NCT06721117 ( http://clinicaltrials.gov ).</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}