Irish Journal of Medical Science最新文献

Deciphering the differential impact of CDK4 mutations on abemaciclib binding in oral squamous cell carcinoma: a precision medicine approach. 解读CDK4突变对口腔鳞状细胞癌中abemaciclib结合的差异影响：一种精准医学方法。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-21 DOI: 10.1007/s11845-025-03994-5

Yu Huang, Mi Zhang, Yi Ni

{"title":"Deciphering the differential impact of CDK4 mutations on abemaciclib binding in oral squamous cell carcinoma: a precision medicine approach.","authors":"Yu Huang, Mi Zhang, Yi Ni","doi":"10.1007/s11845-025-03994-5","DOIUrl":"https://doi.org/10.1007/s11845-025-03994-5","url":null,"abstract":"Background: Precisi on medicine is an emerging approach for disease treatment and its major challenge is the development of drug resistance. Understanding the role of specific mutations in drug resistance is crucial for the development of next-generation therapeutics.Methodology: Cyclin-dependent kinase-4 (CDK4) is a pivotal regulator of the cell cycle, with mutations implicated in oncogenesis in oral squamous cell carcinoma (OSCC). Abemaciclib is one of the major reference drugs designed to inhibit CDK4. This study employs a biophysical approach to examine the binding dynamics between abemaciclib, a selective CDK4 inhibitor, and both wild-type and mutant forms of CDK4. Focusing on the hinge loop region, which includes mutations D99G, R101M, T102K, and P110L, molecular dynamics simulations reveal differential effects on drug binding stability.Results: Findings indicate that while D99G and R101M mutants sustain stable drug interactions, the T102K and P110L mutants exhibit significantly weakened binding, evidenced by altered free energy landscapes, increased structural fluctuations, and diminished hydrogen bond interactions. These findings suggest that patients with CDK4 mutations, particularly T102K and P110L, may exhibit resistance to abemaciclib, necessitating the development of alternative therapeutic strategies.Conclusion: Further studies are essentially required to enhance the precision of cancer treatment, ensuring that each patient receives the most effective therapy based on their unique genetic makeup.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dr AI will see you now: could artificial intelligence replace general practitioners? 人工智能医生现在就要见你了：人工智能会取代全科医生吗？

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-21 DOI: 10.1007/s11845-025-04006-2

Thomas Cronin, John Travers

引用次数: 0

Impact of graves'ophthalmopathy on quality of life, depression, and anxiety among turkish patients. graves眼病对土耳其患者生活质量、抑郁和焦虑的影响。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-19 DOI: 10.1007/s11845-025-04015-1

Ali Osman Gündogan, Nazmi Zengin, Selman Belviranli, Emine Nur Atıcı

{"title":"Impact of graves'ophthalmopathy on quality of life, depression, and anxiety among turkish patients.","authors":"Ali Osman Gündogan, Nazmi Zengin, Selman Belviranli, Emine Nur Atıcı","doi":"10.1007/s11845-025-04015-1","DOIUrl":"https://doi.org/10.1007/s11845-025-04015-1","url":null,"abstract":"Background: To evaluate the quality of life, depression, and anxiety levels of Turkish patients with Graves' Ophthalmopathy (GO) of different disease activity and severity, using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Graves' Ophthalmopathy Quality of Life (GO-QOL) questionnaire and to compare these findings with healthy controls.Methods: This study was designed as a cross-sectional clinical study. The study population included 25 patients with active GO, 25 patients with inactive GO, and 25 patients with non-ophthalmopathy Graves' disease. A group of 30 age- and sex-matched healthy volunteers was included as a control group. All participants underwent a comprehensive ophthalmological examination followed by the administration of the GO-QOL, BDI, and BAI questionnaires.Results: No statistically significant difference was found among the four groups in terms of age or gender (p = 0.752, p = 0.981, respectively). BDI and BAI scores were significantly higher in the Active GO group compared to the Control group (p = 0.001, p = 0.024, respectively). In the Inactive GO group, BDI scores were also higher than the Control group (p = 0.017), while no significant difference was observed in BAI scores (p = 0.087). A comparison of GO-QOL scores revealed that both Active GO and Inactive GO groups had significantly lower scores compared to both the Non-Ophthalmopathy Graves' group (p < 0.001, p = 0.003) and the Control group (p < 0.001, p < 0.001).Conclusion: The present study identified a decrease in quality of life and an increase in depression and anxiety scores in both active and inactive Turkish GO patients.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Referral patterns and patient characteristics observed during the first year of Ireland's inaugural community hub diabetes service: a retrospective analysis. 转诊模式和患者特征观察在爱尔兰的首年社区中心糖尿病服务：回顾性分析。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-19 DOI: 10.1007/s11845-025-03975-8

Katie De Jong, Tommy Kyaw-Tun, John H McDermott, Seamus Sreenan, Colin Davenport

{"title":"Referral patterns and patient characteristics observed during the first year of Ireland's inaugural community hub diabetes service: a retrospective analysis.","authors":"Katie De Jong, Tommy Kyaw-Tun, John H McDermott, Seamus Sreenan, Colin Davenport","doi":"10.1007/s11845-025-03975-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03975-8","url":null,"abstract":"Background: Enhanced Community Care (ECC) for type 2 diabetes mellitus (T2DM) in Ireland introduces episodic, community-based, consultant-led multidisciplinary care of diabetes that in turn supports the general practitioner (GP)-delivered chronic disease management programme (CDMP). The Dublin North West (DNW) hub, Ireland's first fully operational ECC hub, began providing its diabetes service in March 2023.Aims: This study reviewed the first year of the DNW hub's diabetes operations, focusing on referral patterns, patient demographics, clinical characteristics, and CDMP eligibility (only those people living with T2DM with a medical card or a GP visit card are eligible for CDMP for T2DM; otherwise, people living with T2DM must self-pay for GP-provided T2DM care).Methods: A retrospective analysis was conducted on patient charts and hospital databases for all referrals to the DNW hub from March 2023 to March 2024.Results: Out of 204 referrals, 67% were redirected from hospital waiting lists, 22% were direct GP referrals, and 11% were internal from other hub services. The average wait time from referral to first appointment was 8.6 weeks. Attendees were 44% female and 56% male, with an average age of 56.2 years. Notably, only 46% were eligible for CDMP. During the study period, the number of people living with T2DM waiting for diabetes appointments at Connolly Hospital decreased by 61%, with the average waiting time reduced from 11 to 5 months.Conclusions: The first year of activity in the DNW hub illustrates the potential of the ECC model to positively impact hospital waiting lists. Our data also suggests that eligibility to access the CDMP may merit expansion as part of the ongoing implementation of ECC in Ireland.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of CT features and laboratory indicators to aid in the management of patients with portal venous gas identified on imaging. 识别CT特征和实验室指标，以帮助处理门静脉气体在影像学上识别的患者。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-18 DOI: 10.1007/s11845-025-03998-1

Marion Hanley, Munir Saeed, Ronan Lee, Damien C O'Neill, Taranum Naz, Paula Loughlin, Michael J Lee, Martina M Morrin

{"title":"Identification of CT features and laboratory indicators to aid in the management of patients with portal venous gas identified on imaging.","authors":"Marion Hanley, Munir Saeed, Ronan Lee, Damien C O'Neill, Taranum Naz, Paula Loughlin, Michael J Lee, Martina M Morrin","doi":"10.1007/s11845-025-03998-1","DOIUrl":"https://doi.org/10.1007/s11845-025-03998-1","url":null,"abstract":"Background: It can be difficult to distinguish cases of benign portal venous gas (PVG) that can be managed conservatively from forms associated with ischaemic bowel.Purpose: To identify CT, clinical and laboratory factors that may be assist in the decision-making regarding patient management.Methods: All patients in whom PVG was demonstrated on CT imaging were identified over an 8-year period. CT imaging was reviewed for 19 CT features. Clinical findings and laboratory values also retrospectively reviewed. Patients were divided into four groups based on management and outcomes; Group 1, conservatively managed and died, Group 2, conservatively managed and survived, Group 3, operative management and died and Group 4, operative managed and survived.Results: Fifty-six patients had PVG. Overall mortality rate was 54%. Thirty-four percent of patients underwent surgical exploration. Sixty-six percent of patients were managed conservatively. Serum lactate values were found to be highest in Group 1 and lowest in Group 2 (p < 0.001). Neutrophil/lymphocyte ratios significantly differed across the groups. High serum lactate was associated with significantly increased inpatient hospital mortality. CT features of a stenosed or occluded coeliac artery, stenosed or occluded superior mesenteric artery, bowel obstruction, non-obstructed small bowel dilatation and the presence of ascites were associated with significantly increased inpatient hospital mortality.Conclusion: Management of patients with PVG should be determined by assessing the combination of clinical assessment, laboratory values in addition to CT features. Attention may be given to elevated serum lactate levels and specific CT features associated with higher mortality rates.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of objective structured clinical examinations (OSCEs) for medical students, modified during the COVID-19 pandemic. 在COVID-19大流行期间修改的医学生客观结构化临床检查（oses）的比较

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-18 DOI: 10.1007/s11845-025-03976-7

Andrew O'Malley, Nóirín Fitzgerald, Edina Moylett, Geraldine Gaffney, Geraldine McCarthy, Andrew W Murphy, Rosemary Geoghegan, Brian Hallahan

{"title":"A comparison of objective structured clinical examinations (OSCEs) for medical students, modified during the COVID-19 pandemic.","authors":"Andrew O'Malley, Nóirín Fitzgerald, Edina Moylett, Geraldine Gaffney, Geraldine McCarthy, Andrew W Murphy, Rosemary Geoghegan, Brian Hallahan","doi":"10.1007/s11845-025-03976-7","DOIUrl":"https://doi.org/10.1007/s11845-025-03976-7","url":null,"abstract":"Introduction and aims: Objective structured clinical examinations (OSCEs) are an integral part of medical education assessment. The advanced clinical skills (ACS) OSCE examines clinical skills in psychiatry, general practice, obstetrics and gynaecology and paediatrics for fourth-year medical students at the University of Galway. This study compares results between the 2019 OSCE, and two subsequent OSCEs (2020 and 2021) modified to varying degrees secondary to the COVID-19 pandemic. We also examined student's satisfaction and perspectives regarding both modified OSCEs.Materials and methods: Anonymised results between the 2019 (128 min), 2020 (56 min) and 2021 (96 min) ACS OSCEs were compared, and student feedback pertaining to the 2020 and 2021 OSCEs was analysed.Results: A higher total mean mark OSCE result was achieved at the 2020 OSCE (62.95%) compared to the 2019 (59.35%) and 2021 (58.89%) OSCEs (F = 31.83, p < 0.001), with significantly more first-class honours marks attained in 2020 (11.5%) compared to 2019 and 2021 (both 1%) (p < 0.001). Measures of reliability were consistent across all years. A majority of students in both 2020 and 2021 reported the OSCE to be safe, well-coordinated, and fair, but similar numbers of students from both 2020 and 2021 expressed concern that face masks impeded their communication skills.Conclusion: This study demonstrates the feasibility of conducting a modified reliable OSCE during a pandemic. Conducting a 96-min OSCE demonstrated similar results to the pre-COVID-19 pandemic 128-min OSCE, in contrast to a 56-min OSCE where potentially inflated marks were attained.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BDNF-TrkB signalling: a neurotrophic pathway to cardiovascular protection. BDNF-TrkB信号传导：心血管保护的神经营养途径。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-16 DOI: 10.1007/s11845-025-03996-3

Amita Joshi Rana, Md Sadique Hussain, Vikas Jakhmola, Ayesha Sultana, Sreeshma Ravindran Kammarambath, Rajesh Raju, Inamul Hasan Madar

{"title":"BDNF-TrkB signalling: a neurotrophic pathway to cardiovascular protection.","authors":"Amita Joshi Rana, Md Sadique Hussain, Vikas Jakhmola, Ayesha Sultana, Sreeshma Ravindran Kammarambath, Rajesh Raju, Inamul Hasan Madar","doi":"10.1007/s11845-025-03996-3","DOIUrl":"https://doi.org/10.1007/s11845-025-03996-3","url":null,"abstract":"The brain-derived neurotrophic factor (BDNF)-tropomyosin receptor kinase B (TrkB) signaling axis has emerged as a promising frontier in cardiovascular research, particularly in the context of myocardial ischemia/reperfusion (I/R) injury. Originally recognized for its neuroprotective functions, BDNF is now gaining recognition for its cardioprotective properties, including anti-apoptotic effects, improved cardiomyocyte survival, and enhanced contractile function. Acting predominantly through TrkB, BDNF attenuates ischemia-induced apoptosis by downregulating caspase-3 and cleaved caspase-9, while simultaneously promoting cardiomyocyte differentiation and proliferation. Intriguingly, under hypoxic conditions, a shift from p75NTR to TrkB receptor activity amplifies these protective effects. Moreover, BDNF modulates intracellular calcium handling by activating Ca2⁺/calmodulin-dependent protein kinase II (CaMKII), contributing to efficient cardiac muscle contraction and relaxation. Paralleling its role in neurons, BDNF-TrkB signaling may also influence mitochondrial dynamics, energy metabolism, and ATP synthesis, potentially aiding in myocardial recovery. Activation of downstream pathways such as PI3K/Akt/mTOR further suggests a role in metabolic reprogramming, though these effects in cardiac tissue require further validation. Despite growing preclinical evidence, the precise molecular interplay between BDNF's anti-apoptotic, metabolic, and calcium-regulatory roles in the heart remains incompletely understood. Future research should focus on elucidating these mechanisms across cardiac cell types and disease contexts to fully harness the therapeutic potential of BDNF-TrkB modulation. Such strategies may pave the way for personalized, neurotrophin-based interventions in the treatment of ischemic heart disease.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indwelling pleural catheter for malignant pleural effusion: a real-life experience in a tertiary centre with a dedicated pleural service in the Republic of Ireland. 恶性胸腔积液留置胸膜导管：在爱尔兰共和国一个专门的胸膜服务三级中心的现实生活经验。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-15 DOI: 10.1007/s11845-025-03999-0

Lorraine Thong, Mohammed Mitha, Donna Langan, Helen Mulryan, David Breen

{"title":"Indwelling pleural catheter for malignant pleural effusion: a real-life experience in a tertiary centre with a dedicated pleural service in the Republic of Ireland.","authors":"Lorraine Thong, Mohammed Mitha, Donna Langan, Helen Mulryan, David Breen","doi":"10.1007/s11845-025-03999-0","DOIUrl":"https://doi.org/10.1007/s11845-025-03999-0","url":null,"abstract":"Background: Malignant pleural effusion (MPE) is a significant cost of burden and carries a poor prognosis with a median survival of 3-12 months. Indwelling pleural catheters (IPC) have been shown to be effective in improving symptoms in patients with MPE. This study reports our 5-year real-life experience with IPC in patients with MPE from a hospital with a dedicated pleural service in the Republic of Ireland.Methodology: This is a retrospective, single-centre study based in a tertiary hospital. All patients who had IPC inserted by the pleural service in a 5-year period (1st of January 2019 until 31 December 2023) were included in this study. Patients' clinical details and histology results were acquired via the hospital's electronic medical records.Results: During the 5-year period, there were 55 patients who had IPC inserted. Symptom improvement was achieved in almost all patients (n = 54, 98.2%). Our total complication rate was low at 14.5% (n = 8), with the majority being catheter-associated skin infection. Pleurodesis was achieved in 21 (47.8%) patients with the mean and median time to pleurodesis were 115.5 days and 94 days, respectively.Conclusion: IPC is a relatively safe procedure with low complication rates when performed by trained physicians. The additional support of a dedicated pleural service will maximize the benefits of IPC while reducing the complication rates.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound evaluation of muscles in older patients with metabolıc syndrome. 老年metabolıc综合征患者肌肉超声评价。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-14 DOI: 10.1007/s11845-025-04004-4

Ibrahim Ileri, Merve Hafizoglu, Didem Karaduman, Cansu Atbas, Zeynep Sahiner, Ayse Dikmeer, Yelda Ozturk, Merve Guner, Arzu Okyar Bas, Cafer Balci, Mustafa Cankurtaran, Burcu Balam Dogu, Meltem Gülhan Halil

{"title":"Ultrasound evaluation of muscles in older patients with metabolıc syndrome.","authors":"Ibrahim Ileri, Merve Hafizoglu, Didem Karaduman, Cansu Atbas, Zeynep Sahiner, Ayse Dikmeer, Yelda Ozturk, Merve Guner, Arzu Okyar Bas, Cafer Balci, Mustafa Cankurtaran, Burcu Balam Dogu, Meltem Gülhan Halil","doi":"10.1007/s11845-025-04004-4","DOIUrl":"https://doi.org/10.1007/s11845-025-04004-4","url":null,"abstract":"Background: Metabolic syndrome (MetS) is a disease characterized by various metabolic disorders and increases the risk of cardiovascular events. Osteosarcopenia (OS) is the name given to conditions where osteopenia/osteoporosis (OP) and sarcopenia coexist. In this study, the relationship between MetS and bones assessed by dual-energy X-ray absorptiometry (DXA) and muscles assessed by muscle ultrasonography (USG) was investigated.Methods: The study conducted among patients aged 65 and over who applied to the geriatric outpatient clinic between January 2022 and June 2022. This study was a cross-sectional study. There were 161 patients.Results: In the study, 77 (73%) of the patients with MetS were female and the median age of the patients with MetS was 72(9) interquartile range (IQR) years. While OP was present in 18% of patients with MetS, this rate was 41% in those without MetS, and this difference was significant (p = 0.002). There was no difference in OS and sarcopenia rates between the two groups (respectively; p = 0.14, p = 0.09). Gastrocnemius medialis (GM) and transversus abdominis (TA) muscles were significantly thicker in patients with MetS (respectively; p = 0.002, p = 0.003).","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-12 DOI: 10.1007/s11845-025-03995-4

Brian Maloney, Min Seo Jung, Gerard Kearns, Conor Bowe

{"title":"Equestrian-related maxillofacial injuries-a five-year retrospective review.","authors":"Brian Maloney, Min Seo Jung, Gerard Kearns, Conor Bowe","doi":"10.1007/s11845-025-03995-4","DOIUrl":"https://doi.org/10.1007/s11845-025-03995-4","url":null,"abstract":"Background: Equestrian-related activities inherently involve the risk of serious injury. There are few reports of maxillofacial injury patterns and management arising from equestrian activities in the literature.Aims: To investigate maxillofacial fracture presentations at a tertiary trauma centre to identify injury profiles of patients who have sustained equine-based injuries over 5 years.Methods: This work involved a retrospective review of all trauma presentations to our unit over 5 years. The data collected included patient demographics, injury mechanisms and patterns, and management of fractures.Results: The study identified 73 patients with facial fractures resulting from activity with horses between 2020 and 2025. A total of facial fractures were recorded. The mean age was 39.5 (11-86) years. There were 40 (55%) males and 33 (45%) females. Mounted riders accounted for 41% of cases, with 59% being unmounted. The incidence of head injury was 5%. A further 5% had an associated spinal injury. The most common specific mechanism of maxillofacial injury was a direct kick, in 55% of cases. The most commonly affected facial region was the middle third (81%), with zygomaticomaxillary complex fractures most commonly recorded (39%). There was a statistically significant increase in the risk of head injury associated with frontal bone fracture in this group.Conclusion: Activities involving horses pose a high risk of maxillofacial injury. Education should be promoted to increase the usage of helmets with a particular design to protect the facial skeleton, whether mounted or unmounted.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0