Irish Journal of Medical Science最新文献

{"title":"The effects of short-term home-based exercise training via video call in older adults with physically inactive and sedentary life.","authors":"Fazıl Kulakli, İlker İlhanli, İlker Fatih Sari","doi":"10.1007/s11845-025-03981-w","DOIUrl":"https://doi.org/10.1007/s11845-025-03981-w","url":null,"abstract":"<p><strong>Objectives: </strong>Investigating the physical and mental effects of short-term exercise program and motivation with video communication methods such as telephone and internet applications on physically inactive and sedentary older adult's daily lives.</p><p><strong>Methods: </strong>Thirty participants were reached by video calling method. Participants were evaluated twice before and after the program. A 6-min walk test (6MWT), Barthel index for activities of daily living, Tinetti performance oriented mobility assessment (Tinetti POMA) and Geriatric depression scale (GDS) were applied. The standard daily exercise program was applied to all participants for 1 week. Exercise programs were created as endurance, strengthening, stretching and balance exercises.</p><p><strong>Results: </strong>All participants (16 female and 14 male) completed the program. In terms of 6MWT, Tinetti POMA and GDS, a statistically significant improvement was found after the program compared to the pre-program (p < 0.001, p < 0.001 and P < 0.001, respectively).</p><p><strong>Conclusions: </strong>It is possible and effective to organize exercise programs and to follow these with distance video calling applications in physically inactive and sedentary older adults.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can artificial intelligence generate scientific discussion that passes peer review for publication in a high-impact orthopaedic journal?","authors":"Gerard A Sheridan, Lisa C Howard, Michael E Neufeld, Tom R Doyle, Andrew J Hughes, Peter K Sculco, David E Beverland, Donald S Garbuz, Bassam A Masri","doi":"10.1007/s11845-025-03971-y","DOIUrl":"https://doi.org/10.1007/s11845-025-03971-y","url":null,"abstract":"<p><strong>Background: </strong>There is huge interest in the use of artificial intelligence (AI) in the production and assessment of academic material; however, the role of AI remains unclear.</p><p><strong>Aim: </strong>The purpose of this study was to perform a reviewer-blinded assessment of the quality of scientific discussion generated by an advanced AI language model (ChatGPT-4, Open AI) and determine whether this could be recommended for high-impact journal publication.</p><p><strong>Methods: </strong>The introduction, methods and results sections of a recently published article from a high-impact journal were input into a current AI model. The AI application then produced a discussion and conclusion based on the provided text using a standardized prompt. Six experienced blinded reviewers scored all five sections of the hybrid article. A one-way analysis of variance (ANOVA) was used to assess significant differences between scores of each section. Reviewers recommended a decision regarding the suitability of the article for publication.</p><p><strong>Results: </strong>AI composed a scientific discussion and conclusion. The median score was 80 (IQR 70-90) for introduction, 77.5 (IQR 70-90) for methods, 82.5 (IQR 50-90) for results, 60 (IQR 40-75) for discussion and 60 (IQR 40-80) for the conclusion. The median scores for the AI-generated sections were non-significantly lower than other sections (p = 0.37). The majority of reviewers (5/6, 83%) recommended \"acceptance for publication after major revision\". One reviewer recommended \"resubmission with no guarantee of acceptance\". There were no recommendations for rejection.</p><p><strong>Conclusion: </strong>Current AI large language models are now capable of generating content that passes experienced peer review and is acceptable for publication in a high-impact orthopaedic journal, after revision. There are still many concerns regarding the integration of AI into the process of scientific writing, mainly the tendency of AI to rely on advanced pattern recognition and fabricated or inadequate references.</p><p><strong>Level of evidence: </strong>Level IV.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic surgery utilisation and uptake.","authors":"Michael Devine","doi":"10.1007/s11845-025-03970-z","DOIUrl":"https://doi.org/10.1007/s11845-025-03970-z","url":null,"abstract":"","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of potential prothrombotic state markers in Behçet's disease and correlation with vascular ultrasound.","authors":"Hazan Karadeniz, Tunjay Mammadov, Mahi Nur Cerit, Rıza Can Kardas, Aslıhan Avanoglu Guler, Derya Yıldırım, Ibrahim Vasi, Hatice Pasaoglu, Abdulsamet Erden, Hamit Kucuk, Berna Goker, Mehmet Akif Ozturk, Abdurrahman Tufan","doi":"10.1007/s11845-025-03972-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03972-x","url":null,"abstract":"<p><strong>Objective: </strong>The study aims to evaluate the relationship between prothrombotic soluble serum levels of P-selectin, citrullinated histone H3 (CitH3), and growth differentiation factor-15 (GDF-15) and the thickness measurements of the carotid artery, femoral, portal, and jugular veins in patients with Behçet's disease (BD).</p><p><strong>Methods: </strong>Fifty-six BD patients who met the International Study Group criteria and 19 healthy control subjects were enrolled. We compared the groups' differences in B-mode ultrasound findings and biochemical prothrombotic markers. Logistic regression was used to analyze independent factors influencing thrombosis, and a receiver operating characteristic curve was plotted.</p><p><strong>Results: </strong>A total of 34 non-vascular and 22 vascular BD patients (mean age 41.5 ± 11.8 years, 38 (67.9%) male) were included in the study. No significant differences were observed between patients and healthy controls (HCs) in terms of sex, age, and body mass index. BD patients had elevated serum levels of P-selectin, CitH3, and GDF-15 compared to HCs (p < 0.05). CitH3 and GDF-15 levels were significantly higher in BD patients with vascular involvement than those without vascular disease (p < 0.05). The GDF-15 level in vascular BD patients showed a significant correlation with femoral vein thickness.</p><p><strong>Conclusion: </strong>GDF-15 and CitH3 are potential biomarkers that show vascular involvement and thrombosis in BD.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation and impact of a virtual educational intervention for parents of fussy eaters.","authors":"Edel McNamara, Elaine Guinan","doi":"10.1007/s11845-025-03968-7","DOIUrl":"https://doi.org/10.1007/s11845-025-03968-7","url":null,"abstract":"<p><strong>Background: </strong>Fussy eating is generally outgrown but can cause parental anxiety and disrupt family mealtimes. Parental anxiety may lead to coercive feeding practices, which may prolong the period of fussy eating. This project aimed to assess the feasibility and acceptability of delivering first-line advice for the management of fussy eating via a webinar delivered by dietitians.</p><p><strong>Methods: </strong>A descriptive observational design was used to evaluate the feasibility and impact of a monthly educational webinar for parents on fussy eating in children. Content was developed by community dietitians based on established guidelines and feedback from paediatric dietitians and parents. The education webinar was delivered via Zoom 13 times over the course of a year, with recruitment through health centres, social media, and schools. Data was collected through Eventbrite, Zoom analytics, and participant feedback forms. Quantitative data was analysed in Excel, and qualitative responses were thematically analysed for key themes.</p><p><strong>Results: </strong>Over 3300 (n 3334) people registered for the webinar. Attendance numbers per webinar increased from 23 people in July 2023 to 480 people in June 2024. On average, 34% of those who registered attended the monthly webinar. The majority (95%) of attendees remained online for the duration of the webinar. Of 346 feedback responses, 84% would recommend the webinar, 70% felt reassured, and 73% planned to adjust their practices. Thematic analysis revealed key takeaway messages for viewers: reducing mealtime stress, increasing food exposure, reassurance on fussy eating as a phase, fostering positive mealtime environments, and practical strategies.</p><p><strong>Conclusions: </strong>This service evaluation showed that delivery of first-line advice from dietitians on the management of fussy eating via webinar was feasible and acceptable to parents who attended.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the Editor, Commentary on the endoscopic sinus approach for ocular lymphoma.","authors":"Shiona Maria Benedict Fernandes, Ayaanuddin Syed Khaja, Arian Hizomi","doi":"10.1007/s11845-025-03967-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03967-8","url":null,"abstract":"","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of IL-17 and IL-23 ınhibitors on hematological ınflammatory parameters in patients with psoriasis vulgaris.","authors":"Mehmet Semih Çelik, Hamza Aktaş","doi":"10.1007/s11845-025-03969-6","DOIUrl":"https://doi.org/10.1007/s11845-025-03969-6","url":null,"abstract":"<p><strong>Background and objective: </strong>IL-17 and IL-23 inhibitors are widely used as biological agents in patients with psoriasis vulgaris to suppress inflammation and reduce disease severity. This study aimed to examine changes in inflammatory parameters, including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic inflammation index (SII), platelet/hemoglobin ratio (PHR), and red cell distribution width/platelet ratio (RPR), as well as the Psoriasis Area and Severity Index (PASI), in psoriasis patients receiving biological therapy (IL-17 and IL-23 inhibitors).</p><p><strong>Materials and methods: </strong>This retrospective study included 110 patients with psoriasis vulgaris treated with IL-23 (risankizumab, guselkumab or IL-17 inhibitors ( secukinumab, and ixekizumab). Disease severity was assessed using the PASI score. Hematological parameters (NLR, PLR, SII, PHR, and RPR) and PASI values of the patients were recorded and analyzed at baseline (month 0) and during treatment (month 6).</p><p><strong>Results: </strong>A significant decrease was observed in NLR, SII, and PHR values during treatment. NLR decreased significantly from 2.43 ± 1.25 at baseline to 2.12 ± 0.81 at month 6 (p = 0.002). Both IL-17 and IL-23 groups significantly reduced NLR (p = 0.044, p = 0.029, respectively). SII decreased significantly from 695 ± 390 at baseline to 588 ± 288 at month 6 (p = 0.002). Both groups significantly reduced SII levels (p = 0.044, p = 0.018, respectively).PHR decreased significantly from 19.8 ± 6.60 at baseline to 19.2 ± 6.58 at month 6 (p = 0.033).PASI score significantly decreased during treatment (p < 0.001).</p><p><strong>Conclusion: </strong>The significant reduction in NLR and SII levels in both the IL-17 and IL-23 groups suggests that these markers may be used together rather than separately in treatment follow-up. The significant decrease in PHR levels may indicate that IL-17 and IL-23 inhibitors contribute to reducing cardiovascular disease risk in patients with psoriasis vulgaris and promote a favorable long-term prognosis.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage migration inhibitory factor (rs755622) gene polymorphism in vitiligo.","authors":"Doaa Falih Hadi, Abdel-Aziz Ibrahim El-Taweel, Amany Ibrahim Mustafa, Ola Samir El-Shimi, Mahmoud A Rageh","doi":"10.1007/s11845-025-03966-9","DOIUrl":"https://doi.org/10.1007/s11845-025-03966-9","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a cutaneous disease caused by the destruction of functioning melanocytes. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity.</p><p><strong>Aims: </strong>We tried to investigate the association between MIF (rs755622) gene polymorphism and vitiligo susceptibility and its relationship to severity and clinical types of the disease.</p><p><strong>Methods: </strong>Fifty patients with vitiligo and 50 healthy controls were included. Determination of MIF gene (rs755622) single nucleotide polymorphism was conducted using polymerase chain reaction (PCR).</p><p><strong>Results: </strong>There were 18 males and 32 females who had vitiligo, together with 50 control participants of matched age and gender. Taking GG genotype and G allele as references, MIF GC, CC, (GC + CC) genotypes, and C allele demonstrated a substantially higher occurrence in all patients when compared to controls, with a higher risk of developing vitiligo within healthy control subjects.</p><p><strong>Conclusions: </strong>To the best of our knowledge, this is the third study worldwide and the first from Egypt to investigate the association between MIF gene polymorphism (rs755622) with vitiligo susceptibility and severity, and it showed that MIF gene polymorphism (rs755622) may be considered a risk factor for vitiligo susceptibility. Moreover, it may be associated with higher disease extent.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with ST-segment elevation myocardial infarctions among young patients treated in the Mid-West of Ireland: a case series report using secondary data.","authors":"Sandra N Nantumbwe, Roisin Gardiner, Thomas J Kiernan, Niamh M Cummins","doi":"10.1007/s11845-025-03965-w","DOIUrl":"https://doi.org/10.1007/s11845-025-03965-w","url":null,"abstract":"<p><strong>Background: </strong>ST-segment elevation myocardial infarction (STEMI) occurs when the myocardium has been damaged due to an acute occlusion of a coronary artery. STEMI commonly presents in older populations; however, little is known about the prevalence and risk factors among young patients. This is the first study on STEMI in young patients in Ireland.</p><p><strong>Aims: </strong>To determine the prevalence of STEMI and explore the associated risk factors in a cohort of young adults aged 45 years and below in the Mid-West of Ireland.</p><p><strong>Methods: </strong>This is a case series report using secondary data analysis of data collected from patients aged 45 years or below, hospitalized at University Hospital Limerick between January 2012 and December 2019. All patients who had a primary diagnosis of STEMI during this time period were eligible for inclusion. Clinical data were collected via electronic records and included demographic, clinical, and biomarker variables.</p><p><strong>Results: </strong>The sociodemographic characteristics of the STEMI patients revealed that a majority were male (90%), overweight or obese (63%), smokers (69%) and lived in urban areas (74%). Over half of the patients (53%) were diagnosed with hypertension, 69% had a family history of cardiovascular disease (CVD) and 40% had diabetes diagnosis. After initial hospitalization, 64% were readmitted for another procedure.</p><p><strong>Conclusions: </strong>This study identified cardiovascular risk factors among STEMI patients in Ireland as male, smoking, family history of cardiovascular disease, and being overweight or obese. This study hopes to increase awareness of young STEMI patients and inform health promotion initiatives within this cohort.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between socioeconomic deprivation and maxillofacial trauma in Midwest Ireland.","authors":"Saoirse Kilgarriff, Louise Barry, Francesca Lee, Akinsola Ogunbowale, Michael Gilbride, Mark Wilson","doi":"10.1007/s11845-025-03964-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03964-x","url":null,"abstract":"<p><strong>Aim: </strong>The primary objective of this study was to assess the potential association between social deprivation and maxillofacial trauma in Midwest Ireland.</p><p><strong>Method: </strong>A retrospective cohort study of patients undergoing surgical management of maxillofacial fractures, between January 2014 and December 2023, was undertaken. The Pobal 2022 Index utilises recent census data to determine relative deprivation of each electoral region. This database was utilised to assign patients a socioeconomic quartile ranging from Q1 (most deprived) to Q4 (most affluent) and a numerical Deprivation Index Score (DIS).</p><p><strong>Results: </strong>A total of 529 patients were included, of which nine had sustained repeated facial fractures during the predetermined period. The majority of patients were male (86.43%), with a median age was 26.5 (Inter Quartile Range 20 - 36). Whilst the relative frequency of facial fractures was unaffected by area-level deprivation, fracture aetiology varied considerably across the social gradient. The incidence of assault-related fractures was significantly greater in low-income settings (Q1 versus Q3 + Q4, 66.07% versus 40.32%, p = 0.00046). Conversely, sport-related injuries were significantly more prevalent amongst affluent communities (Q3 + Q4 versus Q1 + Q2, 28.06% versus 17.89%, p = 0.0049).</p><p><strong>Conclusion: </strong>The increased incidence of assault-related fractures amongst deprived communities may be secondary to poor social cohesion and higher background levels of community violence. Furthermore, known risk factors for physical violence - namely drug and alcohol misuse - are more prevalent in low-income settings. Public policy should be directed at tackling endemic healthcare disparities that contribute to the unequal distribution of maxillofacial trauma.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}