Irish Journal of Medical Science最新文献

{"title":"The expression trend and regulatory role of miR-484 in patients with gestational diabetes mellitus.","authors":"Yan Hou, Li Wan, Lijia Long","doi":"10.1007/s11845-025-04043-x","DOIUrl":"https://doi.org/10.1007/s11845-025-04043-x","url":null,"abstract":"<p><strong>Objective: </strong>Gestational diabetes mellitus (GDM) is characterized by the onset of abnormal glucose metabolism during pregnancy. This study aims to examine the expression patterns and functional significance of miR-484 in GDM.</p><p><strong>Methods: </strong>The levels of miR-484 in GDM patients were compared to those in normal pregnant women through RT-qPCR. Subsequently, the diagnostic and predictive capacity of miR-484 for GDM was assessed utilizing Receiver Operating Characteristic (ROC) curve. In the next phase, the effects of miR-484 on blood glucose levels and insulin resistance in GDM mice were studied by establishing a GDM mouse model. Finally, pancreatic tissues were isolated to elucidate the influence of miR-484 on inflammation processes and oxidative stress.</p><p><strong>Results: </strong>Elevated levels of miR-484 have been observed in GDM patients, demonstrating a positive correlation with blood glucose levels. ROC curve analysis indicated that miR-484 possesses substantial diagnostic and predictive capabilities for GDM, with an AUC of 0.835, a sensitivity of 80.95%, and a specificity of 82.00%. Furthermore, in GDM models, the downregulation of miR-484 significantly mitigated the adverse effects associated with GDM, leading to notable reductions in blood glucose levels and insulin resistance. Following the down-regulation of miR-484, a notable reduction in the levels of IL-1β, TNF-α, IL-6, and MDA in the pancreas was also observed. Concurrently, there was a significant increase in the levels of SOD and CAT.</p><p><strong>Conclusion: </strong>miR-484 might act as a biomarker for the early-stage recognition of GDM. Down-regulating this molecule is beneficial for lowering blood glucose, insulin resistance, and pancreatic inflammation or oxidative stress.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of a novel radio-opaque 3D printed phantom for simulation training of CT-guided interventional procedure.","authors":"Peter McAnena, Kevin J O'Sullivan, Aidan O'Sullivan, Karan Gupta, Alice Shannon, Leonard W O'Sullivan, Jennifer Ni Mhuircheartaigh","doi":"10.1007/s11845-025-04070-8","DOIUrl":"https://doi.org/10.1007/s11845-025-04070-8","url":null,"abstract":"<p><strong>Background: </strong>Training radiology residents to perform CT-guided procedures can be challenging due to limited access to scanner time, competition for procedures with other residents and fellows and the risk of exposing patients to unnecessary additional radiation due to the inexperience of the primary operator. Simulation training has shown great benefit in reducing patient risk and increasing training opportunities. The aim of this study was to assess the impact of a high-fidelity 3D-printed model as an interventional radiology training tool for trainees.</p><p><strong>Methods: </strong>This study was approved by the local research ethics committee. Using anonymised patient scan data from a prone CT colonography study, the pelvis and two vertebrae were 3D printed in an experimental radiopaque resin. A five-sided mould was created for casting the pelvic phantom. The lower back soft tissue impression was converted to a surface using Geomagic software. This surface was subtracted from a solid base using a Boolean extraction. Gel wax was gently poured into the mould to reduce air bubble formation. The phantom was allowed to cool and solidify overnight. Radiology trainees at our institution were invited to participate in the study and received formal teaching by a musculoskeletal fellowship-trained radiologist before performing two independent CT-guided needle placements on the model. Data were recorded on trainee confidence prior to and after the training session, time to complete the procedure and dose to the model for each attempt and compared using paired t-tests.</p><p><strong>Results: </strong>Twelve radiology trainees took part in the study. Mean total procedure time and dose to the model decreased significantly for the second attempt compared to their first attempt at needle placement in the SI joint (6.9 vs. 4.2 min, p = 0.008, DLP 31.1 vs. 25.9, p = 0.022 respectively). Trainees were significantly more confident in performing a CT-guided SI joint injection following the training session.</p><p><strong>Conclusion: </strong>This study demonstrates that a 3D-printed model hip can provide a valuable training experience for radiology trainees for performing CT-guided interventions and can improve performance and confidence, without conferring any risk to patients. This model could be incorporated into radiology training curricula.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-326 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability.","authors":"Suna Ni, Qian Zhao, Fengjiao Hu","doi":"10.1007/s11845-025-04042-y","DOIUrl":"https://doi.org/10.1007/s11845-025-04042-y","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the diagnostic value and mechanism of action of miR-326 in gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>The study population consisted of 98 GDM patients and 71 healthy pregnant women. Subjects' serum were collected early in pregnancy (10-12 weeks) for cryopreservation. Gene expression was analyzed by RT-qPCR. miR-326 was evaluated by ROC for its diagnostic value. Pearson correlation analysis was performed to calculate the relationship between miR-326 and glycemic index and TLR4. Logistic analysis resulted in risk factors for adverse pregnancy outcomes. CCK8, transwell, and flow cytometry were performed to observe changes in trophoblast function after different treatments. DLR verified the targeting relationship between genes.</p><p><strong>Results: </strong>miR-326 is upregulated in early pregnancy serum of GDM patients and has a predictive diagnostic value for GDM. There is a positive correlation between miR-326 and glycemic indices (HbA1c, FBG, HOMA-IR) in GDM patients, which is a risk factor for inducing adverse pregnancy outcomes. miR-326 inhibitor restored the proliferation, migration, and invasion ability of high glucose-treated (HG group) cells and reduced apoptosis. TLR4 is a target gene of miR-326, and the expression of the two is negatively correlated in GDM patients. Transfection of si-TLR4 resisted the changes in trophoblast cells induced by the use of miR-326 inhibitor.</p><p><strong>Conclusion: </strong>High levels of miR-326 are upregulated in serum of GDM patients in early pregnancy. miR-326 targeted inhibition of TLR4 causes abnormal trophoblast cell function and induces adverse pregnancy outcomes in GDM patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the timing of catheter removal on postoperative urinary continence after radical prostatectomy: a systematic review and meta-analysis.","authors":"Zhenlang Guo, Jun Pan, Zhaohui Wang, Guixing Tang, Franky Leung Chan, Zunguang Bai, Junwei He","doi":"10.1007/s11845-025-04075-3","DOIUrl":"https://doi.org/10.1007/s11845-025-04075-3","url":null,"abstract":"<p><strong>Background: </strong>The optimal length of postoperative catheterisation time after radical prostatectomy remains to be controversial. We performed a meta-analysis to explore the impact of catheter removal time on urinary continence after radical prostatectomy (RP).</p><p><strong>Methods: </strong>The MEDLINE, Embase, Cochrane Library, and Web of Science databases were searched to identify eligible studies published before June 2025. The inverse variance method with random-effects modeling was used to calculate summary odds ratios (ORs) and their associated 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Fifteen studies comprising 4,159 patients who underwent RP matched our eligibility criteria. Early catheter removal was associated with an increased likelihood of urinary retention (OR = 2.20, 95% CI: 1.22-3.95) in the postoperative day (POD) 2 group compared to more than POD 2 days group. However, this significant difference was not observed in patients with POD 3 (vs POD > 3, OR = 1.37, 95% CI: 0.37-5.09), patients with POD 4 (vs POD > 4, OR = 4.41, 95% CI: 0.88-22.18), and patients with POD 7 (vs POD > 7, OR = 6.49, 95% CI: 0.80-52.83). Moreover, early removal of the catheter was not associated with an increased risk of urinary incontinence (OR = 1.25, 95% CI: 0.58-2.68), anastomotic leakage (OR = 1.22, 95% CI: 0.76-1.96), vesical neck stenosis (OR = 0.73, 95% CI: 0.09-5.83) compared to the regular group. The findings are robust, as indicated by sensitivity and meta-regression analyses.</p><p><strong>Conclusions: </strong>Early catheter removal seems feasible, but one should be aware of the increased risk of urinary retention, especially in patients of POD 2. Moreover, it seems to be safe in terms of urinary incontinence, anastomotic leakage, and vesical neck stenosis. We hope that our findings will help to guide the standardised management of catheter removal after RP, and early catheter-free discharge after RP may provide relevant clinical benefits for these patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why do patients attend out-of-hours GP services in Ireland?","authors":"Aisling Farrell, Alannah McCarthy, Roseanne Tobin, Elizabeth Bowen, Audrey Russell, Aisling Jennings","doi":"10.1007/s11845-025-04071-7","DOIUrl":"10.1007/s11845-025-04071-7","url":null,"abstract":"<p><strong>Background: </strong>The attendance at out-of-hours GP services in Ireland has increased over the last number of years. However, the reasons for the increased demand have not been explored in the literature.</p><p><strong>Aims: </strong>The aim of this study was to identify the factors contributing to the use of out-of-hours GP services in Ireland from the patient's perspective.</p><p><strong>Methods: </strong>A survey was designed and piloted prior to distribution. The survey was completed by patients attending an out-of-hours GP treatment centre in Cork, Ireland over a four-month period. Using a combination of forced choice items, free text boxes and five-point Likert scales, questions explored the reasons for attendance and experiences of patients with the out of hours service. Descriptive statistics were used to analyse the data on MS Excel.</p><p><strong>Results: </strong>80 people completed the survey. 75% (60/80) of participants stated that they had not attempted to contact their GP prior to contacting the out-of-hours centre. 49% (39/80) contacted the out-of-hours service as they felt that their issue was urgent. 36% (29/80) stated that they were unable to obtain an appointment with their GP and 15% (12/80) stated that the out-of-hours service was more convenient than regular GP hours. 29% (23/80) had symptoms for more than 4 days prior to contacting out-of-hours. The most common presentation was coryzal and upper respiratory tract symptoms, grouped collectively as 'Ear Nose and Throat' (ENT) symptoms at 34% (27/80).</p><p><strong>Conclusions: </strong>This study provides insight into the factors driving patient attendance at the out-of-hours GP service in Ireland. These factors include perceived urgency of symptoms, an inability to obtain an appointment with their own GP and in some cases, the convenience of out-of-hours services. There is a demand for targeted patient educational campaigns and increased resourcing for GP services during the daytime to reduce reliance on out-of-hours GP services.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold-water, Sulphur and 'the itch': James Henry's principles for conducting controlled trials (1843).","authors":"Max Cooper, Jo Middleton, Sarah Cooper","doi":"10.1007/s11845-025-04027-x","DOIUrl":"https://doi.org/10.1007/s11845-025-04027-x","url":null,"abstract":"<p><strong>Background: </strong>James Henry (1798-1876) was a Dublin physician and classical scholar best remembered for his translation of Virgil's Aeneid. Little is recorded about his medical practice.</p><p><strong>Aim: </strong>To describe Henry's 1843 proposal for a controlled trial of treatment for 'the itch'.</p><p><strong>Method: </strong>Qualitative examination of historical medical journals.</p><p><strong>Results: </strong>Henry suggests taking twelve patients and treating six with cold-water treatment and six with standard treatment (sulphur). Henry's proposal sets out four general principles for selecting diseases to study the alleged benefits of cold-water treatment. First, the condition should be one upon which it is safe to experiment. Second, the disease should be 'visible and tangible, and… cannot be simulated or misrepresented, or misunderstood'. Third, it should have no spontaneous recovery. Finally, there should already be a 'certain [i.e. proven] remedy'. Henry had published in 1834 on sulphur as a laxative. By calling for twelve participants, it is possible that Henry's proposal was influenced by the writing of Francis Hauksbee the Younger (1743) and James Lind (1753).</p><p><strong>Conclusion: </strong>Although there is no evidence that Henry's trial ever took place, his proposal and principles for selecting a disease to study reveal a critical and ethical mind. It also constitutes a notable landmark on the journey towards formal controlled trials.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of royal jelly consumption on oxidative stress, anti-oxidant markers and physical activities of patients with multiple sclerosis: a randomized double-blind placebo-controlled study.","authors":"Zahra Eslamifar, Farzaneh Manucheri, Saeed Ghanbari, Mohammadreza Zandi, Susan Sabbagh","doi":"10.1007/s11845-025-04009-z","DOIUrl":"https://doi.org/10.1007/s11845-025-04009-z","url":null,"abstract":"<p><strong>Background: </strong>The study investigates the effects of royal jelly (RJ) on patients with relapsing-remitting multiple sclerosis (RRMS), focusing on its potential to reduce oxidative stress, improve antioxidant levels, and enhance quality of life.</p><p><strong>Methods: </strong>A total of 61 RRMS patients were randomly assigned to either a RJ group or a placebo group, receiving a daily dose of 500 mg for 45 days. Key outcomes measured included expanded disability status scale (EDSS) scores, levels of malondialdehyde (MDA), and activities of antioxidants such as catalase (CAT) and superoxide dismutase (SOD), along with assessments of fatigue and quality of life.</p><p><strong>Results: </strong>Results indicated that the RJ group experienced a significant reduction in EDSS scores (P < 0.001) and MDA levels (P < 0.0001). The activity of SOD and CAT after consumption of RJ had increased significantly (P < 0.0001, P < 0.001), respectively. Additionally, improvements were noted in some parameters of fatigue and quality of life measures.</p><p><strong>Conclusion: </strong>The findings suggest that RJ may help decrease oxidative stress and improve motor function and anti-oxidant capacity in MS patients, potentially slowing disease progression.</p><p><strong>Trial registration: </strong>This study was registered on the Iranian Registry of Clinical Trials (Registration No. IRCT20220116053732N1) on 2022.05.08.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of plantar pressure distribution patterns of patients with ankylosing spondylitis and asymptomatic healthy individuals: a cross-sectional study.","authors":"Nazli Cigercioglu, Zilan Bazancir-Apaydin, Gul Baltaci, Umut Kalyoncu, Hande Guney-Deniz","doi":"10.1007/s11845-025-04064-6","DOIUrl":"https://doi.org/10.1007/s11845-025-04064-6","url":null,"abstract":"<p><strong>Background: </strong>Ankylosing Spondylitis (AS) is an inflammatory chronic disease that causes postural changes. As a result of these changes decreased hip flexion, increased knee flexion and plantar flexion of ankle are developed.</p><p><strong>Aims: </strong>The aim of the study is to compare plantar pressure distribution results in patients with AS and healthy individuals and to determine the relationship between clinical and functional parameters in patients with AS.</p><p><strong>Methods: </strong>Twenty-five patients (median age = 42.2 ± 2.1 years) with AS and 25 healthy individuals (median age = 44.4 ± 1.7 years) were included in the study. The maximum foot pressure (FP_max), average pressure, center of pressure angle (CoP), forefoot load (FFL), rearfoot load (RFL), foot progression angle (FPA) and foot angle (FA) were determined by pedobarographic analysis. Spinal mobility was assessed with lumbar flexion, lateral flexion, and tragus-wall distance. Functional status and disease-related symptoms were assessed with BASDAI, BASFI and ASQoL.</p><p><strong>Results: </strong>There were no differences between static and dynamic pedobarographic analysis parameters between the AS group and the control group (p > 0.05). Self-rated functional levels parameters, pain, and stiffness were higher in the AS group (p < 0.05). Lumbar flexion (p = 0.187) and tragus-to-wall distance (p = 0.196) were similar in two groups. Self-rated parameters were correlated with pain, stiffness, and lateral flexion (p < 0.05). Lateral flexion correlated with FA and FFL; tragus to wall distance correlated with FP_max and CoP and RFL; lumbar flexion correlated with FA (p < 0.05).</p><p><strong>Conclusion: </strong>The results showed that there was no difference plantar pressure distribution but there was a difference in spinal mobility in AS group compared healthy individuals.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PANoptosis-related gene APAF1 may contribute to the progression of sepsis.","authors":"Zhiqin Kang, Jing Huang, Hongxuan Liu","doi":"10.1007/s11845-025-04041-z","DOIUrl":"https://doi.org/10.1007/s11845-025-04041-z","url":null,"abstract":"<p><strong>Background: </strong>This research tried to identify a PANoptosis-related gene marker for sepsis early diagnosis and treatment.</p><p><strong>Methods: </strong>We collected transcriptional datasets from the Gene Expression Omnibus (GEO) database and performed differential expression analysis using the R language and the \"limma\" package. Functional enrichment analysis was conducted using the \"clusterProfiler\" package, and Protein-Protein Interaction (PPI) analysis was carried out. Transcription factor (TF) binding sites were predicted using FIMO tool. Gene set enrichment analysis (GSEA) and disease ontology (DO) analysis were performed. Immune infiltration analysis was conducted using CIBERSORT, ssGSEA, and the xCell algorithm.</p><p><strong>Results: </strong>A total of 18 PANoptosis-related genes were found to express significantly differentially between sepsis and normal samples, and APAF1 was selected as the target gene. APAF1 expressed higher in sepsis compared to normal samples. ROC analysis indicated its diagnostic value. TF HIF1A and 4 miRNAs might be regulators of APAF1. APAF1 was negatively related to CD8 T cells and resting NK cells, and positively related neutrophils, macrophages M0, T cells gamma delta, and plasma cells. Many target drugs were detected high sensitivity to APAF1 and its related TFs.</p><p><strong>Conclusion: </strong>PANoptosis-related gene APAF1 was identified to highly express in sepsis and it was valuable in diagnosis.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between cognitive function and physical performance in established users of a lower limb prosthesis.","authors":"Senem Demirdel, Rahime Yılmaz, Selma Küçük, Osman Söyler","doi":"10.1007/s11845-025-04049-5","DOIUrl":"https://doi.org/10.1007/s11845-025-04049-5","url":null,"abstract":"<p><strong>Background: </strong>Cognitive abilities are important for mobility functions in individuals with amputation.</p><p><strong>Aims: </strong>To investigate the association between cognitive function and physical performance in established users of a lower limb prosthesis.</p><p><strong>Methods: </strong>This prospective cross-sectional study was included established users of a lower limb prosthesis (N = 62; mean age ± SD, 41.33 ± 14.76 years). The Montreal Cognitive Assessment was used to evaluate cognitive function. The Timed Up and Go Test under single-task and dual-task conditions, the Four Square Step Test, and the 3-m Backward Walk Test were used for physical performance assessment.</p><p><strong>Results: </strong>An independent association was found of the Montreal Cognitive Assessment to the dual task Timed Up and Go Test (AdjR² = 0.168, p = 0.003), the Four Square Step Test (AdjR² = 0.25, p = 0.003) and the 3-m Backward Walk Test (AdjR² = 0.159, p = 0.032). An increase of 1 point in the Montreal Cognitive Assessment was associated with a reduction of 0.681 s (95% CI, 1.116-0.246) in the the dual task Timed Up and Go Test, 0.378 s (95% CI, 0.617-0.138) in the Four Square Step Test, and 0.255 s (95% CI, 0.487-0.022) in the 3-m Backward Walk Test.</p><p><strong>Conclusions: </strong>The results of this study revealed an independent association between global cognitive function and functional mobility under dual-task conditions, dynamic balance, and backward walking performance in established users of a lower limb prosthesis. These results emphasize that cognitive functions should be taken into account in interventions aimed at improving challenging physical performance in established users of a lower limb prosthesis.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}