Irish Journal of Medical Science最新文献

{"title":"miR-92a-3p and miR-182-3p as potential biomarkers for the differential diagnosis of gestational diabetes mellitus and its correlation with pregnancy outcomes.","authors":"Xiaoshuang Du, Qi Li, Zhenlan Wu, Lin Xue","doi":"10.1007/s11845-025-03953-0","DOIUrl":"https://doi.org/10.1007/s11845-025-03953-0","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) poses a significant threat to the health of both the mother and the fetus during pregnancy, potentially resulting in adverse pregnancy outcomes (APOs), including preterm labor and obstructed labor.</p><p><strong>Objective: </strong>This study aimed to evaluate the expression of serum microRNA (miR)-92a-3p and miR-182-3p in GDM and their clinical significance, providing ideas for clinical diagnosis and management.</p><p><strong>Methods: </strong>A total of 80 patients with GDM served as the GDM group, and 80 healthy pregnant females served as controls. Quantitative real-time PCR was utilized to examine the relative expression of miR-92a-3p and miR-182-3p. Logistic regression modeling and ROC curves were utilized to evaluate the clinical significance of serum miR-92a-3p and miR-182-3p in GDM.</p><p><strong>Results: </strong>miR-92a-3p and miR-182-3p was upregulated in GDM patients. The expression of miR-92a-3p and miR-182-3p were positively correlated with 1 h OGTT, 2 h OGTT, and HOMA-IR. The ROC curves demonstrated that the areas under the curve (AUCs) of miR-92a-3p, miR-182-3p, and the combination of the two in the diagnosis of GDM were 0.890, 0.813, and 0.921, respectively. Elevated levels of serum miR-92a-3p and miR-182-3p were linked to APOs. The AUCs of miR-92a-3p, miR-182-3p, and the combination of the two for predicting APOs were 0.795, 0.775, and 0.845, respectively.</p><p><strong>Conclusion: </strong>miR-92a-3p and miR-182-3p exhibited diagnostic value for GDM and were correlated with APOs in patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination therapy with vitamin E and ertugliflozin in patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus: a randomized clinical trial.","authors":"Adil Khaliq, Haroon Badshah, Yasar Shah","doi":"10.1007/s11845-025-03945-0","DOIUrl":"https://doi.org/10.1007/s11845-025-03945-0","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity in type 2 diabetes mellitus (T2DM), with shared pathophysiological mechanisms, including insulin resistance, oxidative stress, and inflammation.</p><p><strong>Objectives: </strong>This study evaluates the effects of vitamin E and ertugliflozin, individually and in combination, alongside standard pioglitazone therapy, on hepatic and metabolic parameters in patients with NAFLD and T2DM.</p><p><strong>Methods: </strong>A 24-week, double-blind, randomized, controlled clinical trial on 173 patients with NAFLD and T2DM was assigned into four groups: vitamin E (n = 42), pioglitazone (n = 43), ertugliflozin (n = 44), and vitamin E + ertugliflozin (n = 44) combination therapy. The primary outcome was to monitor changes in liver steatosis assessed via ultrasound. Secondary outcomes included evaluation of liver enzymes, glycemic control, fibrosis markers, and lipid profiles.</p><p><strong>Results: </strong>Combination therapy of vitamin E + ertugliflozin showed the highest decrease in liver fat content, with 11 participants achieving successful Grade 0 (p < 0.001). Significant improvements were also observed in glycemic control, HbA1c, triglycerides, and liver enzymes. Ertugliflozin monotherapy showed significant efficacy in improving liver enzymes, glycemic parameters, and fibrosis markers. Pioglitazone improved the initial stage of NAFLD but had a limited impact on advanced fibrosis. Ertugliflozin, in combination with vitamin E, decreases oxidative stress; however, vitamin E by itself has no impact on the metabolic and fibrosis index.</p><p><strong>Conclusion: </strong>The ertugliflozin and vitamin E combination is a very effective treatment for patients with NAFLD and T2DM. It improves hepatic steatosis and metabolic indicators. Exploration is required for combination therapy in order to assess the prolonged efficacy and safety of the treatment.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A trend analysis of weight gain during the nutritional recovery period of severe acute malnutrition among children.","authors":"Mrunali Rahud, Sambasivan Venkat, Deepika Morale, Ravindra Gurav","doi":"10.1007/s11845-025-03944-1","DOIUrl":"https://doi.org/10.1007/s11845-025-03944-1","url":null,"abstract":"<p><strong>Background: </strong>Undernutrition, a significant global health concern, affects children under 5 years old. It encompasses stunting, wasting, and nutritional deficits. In India, 35.5% of children are stunted, 32.1% are underweight, 19.3% are wasted, and 7.7% are severely wasted. Severe acute malnutrition (SAM) is a critical form of undernutrition. Nutritional Rehabilitation Centers (NRCs) provide medical and nutritional assistance to malnourished children, using therapeutic feeding diets like F-75 and F-100. Anthropometric measurements track progress during hospitalization, ensuring effective interventions.</p><p><strong>Aims: </strong>The aim of the study is to determine the rate at which weight gain occurs in children during the nutritional recovery period.</p><p><strong>Methods: </strong>Total enumeration of children admitted to the Nutritional Rehabilitation Center from May 2022 to April 2023 were taken under study, and data was collected from the case records. Descriptive statistics was used to summarize the data. Paired t-test was used for comparison of the mean.</p><p><strong>Results: </strong>Nearly equal proportions of boys (52.6%) and girls (47.4%) were included, with the majority under 24 months old. The mean duration of stay was 14.26 ± 1.75 days. The average total weight gain was 0.87 ± 0.27 kg, with girls gaining slightly more (0.86 ± 0.29 kg) than boys (0.88 ± 0.25 kg). The rate of weight gain was 8.56 ± 3.16 g/kg/day, higher among girls (8.92 ± 2.68) than boys (8.24 ± 3.53). Around 46.7% achieved > 15% target weight gain.</p><p><strong>Conclusion: </strong>The study highlights gender disparities favoring better nutritional recovery among girls and younger children at NRCs, advocating for early interventions to reduce undernutrition morbidity and mortality.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of stress and earthquake-related trauma on fibromyalgia: a longitudinal study.","authors":"Muhammed Aslan, Irada Ibramkhalilova, Melis Mutlu, Fatih Albayrak, Pinar Gunel, Bunyamin Kisacik","doi":"10.1007/s11845-025-03955-y","DOIUrl":"https://doi.org/10.1007/s11845-025-03955-y","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia (FM) is a chronic disorder characterized by widespread pain, fatigue, and psychological symptoms. While psychological trauma is known to affect FM severity, the impact of natural disasters, such as earthquakes, remains insufficiently studied.</p><p><strong>Aim: </strong>This study aimed to evaluate the effects of earthquake-related trauma on fibromyalgia severity and quality of life.</p><p><strong>Methods: </strong>A total of 100 patients diagnosed with fibromyalgia per the American College of Rheumatology 2016 criteria were enrolled. All participants experienced the February 2023 earthquakes in Turkey. Disease activity and quality of life were assessed using the Fibromyalgia Impact Questionnaire (FIQ) at 1 and 6 months post-earthquake. The Impact of Event Scale-Revised (IES-R) was employed to measure psychological trauma levels. Statistical analyses included paired t-tests and Pearson's correlation coefficients.</p><p><strong>Results: </strong>FIQ scores significantly improved from 1 month (74.97 ± 20.15) to 6 months (67.25 ± 16.39) post-earthquake (p < 0.001). A strong positive correlation was found between IES-R and FIQ scores at 1 month (r = 0.636, p < 0.01) and 6 months (r = 0.411, p < 0.01). Subgroups with home or family loss showed more pronounced FIQ scores, while groups exposed to new stress factors did not show significant changes over time (p = 0.307).</p><p><strong>Conclusions: </strong>This study demonstrates that earthquake-related trauma exacerbates fibromyalgia symptoms, highlighting the necessity of integrating psychological and stress management interventions in the treatment of FM, particularly in disaster-affected regions.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing chronic low back pain: investigating the role of Pilates in subacute management-a randomized controlled trial.","authors":"Hatice Kubra Asik, Tugba Sahbaz","doi":"10.1007/s11845-025-03939-y","DOIUrl":"https://doi.org/10.1007/s11845-025-03939-y","url":null,"abstract":"<p><strong>Background: </strong>Subacute low back pain (LBP) is a critical phase that can determine long-term patient outcomes. Exercise therapy, including Pilates, is widely used to manage LBP, but its effectiveness in the subacute phase remains underexplored. This randomized controlled trial aims to compare the effects of an 8-week Pilates-based intervention versus a home exercise program on pain intensity, functional disability, and quality of life in patients with subacute LBP.</p><p><strong>Methods: </strong>Sixty-six participants with subacute LBP were randomized into two groups: a supervised Pilates group and a home exercise group. Pain intensity (Visual Analog Scale), functional disability (Roland-Morris Disability Questionnaire), and quality of life (Short Form-36) were assessed at baseline, post-intervention, and 3-month follow-up.</p><p><strong>Results: </strong>Both groups exhibited significant improvements in all outcome measures (p < 0.001). However, the Pilates group showed superior reductions in pain intensity (p = 0.010 post-treatment, p = 0.002 at follow-up) and functional disability (p = 0.009 and p = 0.002). Additionally, quality of life scores improved more significantly in the Pilates group, particularly in physical function (p = 0.031 and p = 0.025) and general health (p = 0.005 and p = 0.012).</p><p><strong>Conclusions: </strong>Pilates-based rehabilitation was more effective than a home exercise program in improving pain, disability, and quality of life in patients with subacute LBP. These findings support the inclusion of Pilates in early-stage rehabilitation to prevent chronicity.</p><p><strong>Trial registration: </strong>Clinical Trials Number: NCT06699511.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of machine learning models in a resource-constrained environment.","authors":"Addison M Heffernan, Jaewook Shin, Kemunto Otoki, Robert K Parker, Daithi S Heffernan","doi":"10.1007/s11845-025-03951-2","DOIUrl":"https://doi.org/10.1007/s11845-025-03951-2","url":null,"abstract":"<p><strong>Background: </strong>Machine learning models (MLMs) used to influence surgical decision making often require large and complex datasets upon which to train. However, there is a paucity of literature pertaining to the ability to apply standard MLMs to small ICU datasets within resource-constrained institutions.</p><p><strong>Methods: </strong>ML models were applied to a prospective cohort of critically ill mechanically ventilated patients from a teaching hospital in rural Kenya. Characteristics included an ICU scoring system specifically for resource-constrained environments (Tropical Intensive Care Score (TropICS)). Outputs included AUC of the ROC and the feature importance table. Python-based MLMs included XGBoost and KNN. AUC of the ROC was calculated to predict mortality as the primary endpoint.</p><p><strong>Results: </strong>There were 294 patients, with an average age of 40.2 years, 64.3% male, 23.8% trauma, and an overall mortality of 60.2%. With respect to mortality patients who died were older (43.5 versus 35 years; p < 0.001), but with no difference in male gender (64.8% versus 63.8%; p = 0.9), or having been transferred from outside facilities (34% versus 21.5%; p = 0.5). Whilst there was no difference in the rate of tachycardia or acidosis, patients who died were more likely to present with hemodynamic instability (31% versus 6%; p < 0.001) and higher clinical severity scores. In predicting mortality, the ML models performed very well (XGBoost AUC = 0.82). Within MLM feature importance, the Tropical Intensive Care Score (TropICS) performed as well as APACHE-II and the SAPS.</p><p><strong>Conclusion: </strong>ML models can be effectively applied to a small ICU dataset within resource-constrained environments. ML models must demonstrate functionality prior to incorporating within prospective clinical predictive models. Contextualized ICU scoring systems (TropICS) performed well within MLMs.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney function estimation equations: a narrative review.","authors":"Nisha Abdul Khader, Veena Ganesh Kamath, Shobha Ullas Kamath, Indu Ramachandra Rao, Attur Ravindra Prabhu","doi":"10.1007/s11845-025-03874-y","DOIUrl":"10.1007/s11845-025-03874-y","url":null,"abstract":"<p><p>Glomerular filtration rate (GFR) as a marker of kidney function is important in health and disease management because decreased kidney function is associated with all-cause and cardiovascular mortality, progression of kidney disease, predisposition to acute kidney injury (AKI), and for drug dosage modification. While measured glomerular filtration rate (mGFR) is acknowledged as the most accurate method for evaluating kidney function, it is at present not feasible to be applied in the clinical arena. Estimated glomerular filtration rate (eGFR) is preferred due to its convenience, cost-effectiveness, and seamless integration into standard clinical practice for kidney function evaluation. The presence of multiple equations for eGFR with applications to differing populations makes their use challenging for clinicians. We reviewed available estimated glomerular filtration rate (GFR) equations and their application in different clinical settings both in normal and chronic kidney disease (CKD) patients. These formulae incorporate serum creatinine and/or serum cystatin C levels and correlate them with measured kidney function. Among the many available equations, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is the most recommended due to its robustness and accuracy across diverse patient populations. Strengths and limitations of different eGFR equations are discussed emphasizing the importance of selecting the appropriate equation based on specific patient demographics and clinical scenarios. There is need for regional validation studies to ensure the global applicability of these equations, considering the variations in population characteristics.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"725-743"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-144-3p participates in the regulation of gestational diabetes mellitus by targeting FOXO1.","authors":"Meiyi Chen, Shaomeng Sun, Lei Ma, Li Bian, Biao Zhao, Haiyong Zeng","doi":"10.1007/s11845-025-03894-8","DOIUrl":"10.1007/s11845-025-03894-8","url":null,"abstract":"<p><strong>Background: </strong>The pivotal role of microRNAs (miRNAs) in the pathogenesis of gestational diabetes mellitus (GDM) have been increasingly highlighted in recent studies.</p><p><strong>Aims: </strong>To investigate miR-144-3p expression in patients with GDM and its potential mechanisms in GDM.</p><p><strong>Methods: </strong>According to the inclusion criteria, 98 pregnant women with GDM and 98 normal pregnant women were statistically selected. The levels of miR-144-3p were determined by RT-qPCR. The ROC curve was used to evaluate the diagnostic value of miR-144-3p for GDM. Pearson analysis was used to analyze the correlation. HRT-8/SVneo cells were induced by high glucose in vitro to mimic the high glucose environment of GDM. On this basis, the cell models of miR-144-3p overexpression and knockdown were established to investigate the potential mechanism of miR-144-3p in GDM.</p><p><strong>Results: </strong>The level of miR-144-3p in GDM group was markedly higher than that in normal pregnant women. In terms of predicting GDM, miR-144-3p demonstrated high accuracy. MiR-144-3p was positively linked to blood glucose markers in GDM. Further investigation has confirmed that miR-144-3p harbors a binding site for FOXO1 and can directly modulate its expression. Moreover, miR-144-3p targeted FOXO1 to affect the proliferation of trophoblast cells.</p><p><strong>Conclusion: </strong>The expression of miR-144-3p is elevated in pregnant women with GDM. MiR-144-3p may be involved in the regulation of GDM by targeting FOXO1.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"545-552"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A radiographic analysis of humerus shaft fractures to predict non-union.","authors":"Alexander Price, Conor O'Driscoll, Nicolaas Kotze, Danilo Vukanic, Petr Jemelik, May Cleary, David O'Briain","doi":"10.1007/s11845-025-03905-8","DOIUrl":"10.1007/s11845-025-03905-8","url":null,"abstract":"<p><strong>Background: </strong>Humeral shaft fracture non-union rates of up to 33% have been reported when managed non-operatively. When managed surgically, non-union rates of 10% have been seen. The initial radiographic displacement parameters may be of significance in determining whether non-operative treatment might fail.</p><p><strong>Aims: </strong>To determine whether the initial radiographic displacement of humeral shaft fractures can predict non-union rates and assist in decision-making for surgical intervention.</p><p><strong>Methods: </strong>A retrospective cohort study was performed to identify all patients with humeral shaft fractures presenting to a regional trauma centre over a three-year period. Three-observer measurements were taken on defined radiographic parameters. These were compared between groups treated successfully with surgery and with non-operative intervention. A subset group was identified who failed non-operative treatment and required delayed surgery. Statistical analysis was performed to determine whether the group that failed non-operative treatment met the proposed radiographic parameters predicting treatment failure.</p><p><strong>Results: </strong>Eighty patients were identified over the defined three-year period. Failure of non-operative management occurred in 6/43 (13.95%) patients. Failed conservative treatment was associated with increased age, female gender, and increased AP translation of lateral radiographs. Fractures successfully treated non-operatively showed a significantly lower AP translation on the lateral radiographs compared to patients who failed non-operative treatment 9.69 mm (IQR 4.90-14.05 mm) versus 22.61 mm (IQR 15.73-23.83 mm), p-value = 0.042.</p><p><strong>Conclusion: </strong>Significant initial AP displacement may be associated with failure of non-operative management. This study highlights the importance of initial radiographic parameters of displacement in predicting possible failure of non-operative management for midshaft humerus fractures.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"699-706"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurologists' perspectives of cannabis-based medicines: results from an all-Ireland survey.","authors":"Michael Savio, Hugh Kearney, Eric J Downer","doi":"10.1007/s11845-025-03880-0","DOIUrl":"10.1007/s11845-025-03880-0","url":null,"abstract":"<p><strong>Background: </strong>Advancements continue to be made in the development of medicines containing components of the Cannabis sativa L. plant. Consultants can prescribe specific cannabis-based products for a restricted set of indications in Ireland, with neurologists being at the forefront of therapy. Much debate on the therapeutic potential/efficacy of such cannabis-based products exists.</p><p><strong>Aim: </strong>The objective of this study was to conduct a national survey to determine the perspectives/views of Irish neurologists regarding the use of cannabis-based medicines.</p><p><strong>Methods: </strong>An online anonymous survey was conducted to capture the perspectives and experiences of neurologists in Ireland regarding cannabis-based therapeutics.</p><p><strong>Results: </strong>Thirty-four neurologists completed the survey in full, with study participants rating their knowledge of cannabis-based medicines as average. Data presented herein indicate that there is a need for educational programmes on the cannabinoid system and cannabinoid-based medicines, and the findings indicate that neurologists are interested in the use of cannabinoid-based medicines in their practice. Study participants were more divided with regard to the clarity of the process for accessing cannabis-based medicines, and the consensus is that the application process is unclear. Approximately one-third of participants have made an application to access medicinal cannabis-based products on behalf of a patient.</p><p><strong>Conclusions: </strong>Data presented herein indicates that the majority of neurologists surveyed are aware of the current systems in place to access cannabis-based products for medicinal use in Ireland and that some engagement with these systems has taken place. A key finding is that educational programmes on the cannabinoid system and cannabis-based medicines are required.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":"687-697"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}