Irish Journal of Medical Science最新文献_第3页

The effect of kinesiophobia on motor symptoms in individuals with Parkinson's Disease. 运动恐惧症对帕金森病患者运动症状的影响

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-30 DOI: 10.1007/s11845-025-04103-2

Miray Baser, İsmail Uysal, Fatih Özden, Mehmet Özkeskin, Zehra Benzer, Funda Alparslan

{"title":"The effect of kinesiophobia on motor symptoms in individuals with Parkinson's Disease.","authors":"Miray Baser, İsmail Uysal, Fatih Özden, Mehmet Özkeskin, Zehra Benzer, Funda Alparslan","doi":"10.1007/s11845-025-04103-2","DOIUrl":"https://doi.org/10.1007/s11845-025-04103-2","url":null,"abstract":"Background: Parkinson's Disease (PD) is characterized by motor and non-motor symptoms that impair balance, mobility, and overall physical function. Kinesiophobia, defined as the fear of movement due to pain or injury concerns, may further exacerbate these impairments by promoting activity avoidance. This study aimed to investigate the impact of kinesiophobia on motor symptoms in individuals with PD.Methods: A total of 51 individuals diagnosed with PD were included in the study. Participants were divided into two groups-low and high kinesiophobia-based on their scores on the Tampa Scale for Kinesiophobia (TSK). Motor assessments included the Unified Parkinson's Disease Rating Scale (UPDRS), Berg Balance Scale (BBS), Timed Up and Go (TUG) test, Activities-specific Balance Confidence (ABC) scale, and Six-Minute Walk Test (6MWT).Results: High kinesiophobia was significantly associated with older age and longer disease duration. MANCOVA revealed significant group differences in balance (BBS) and walking endurance (6MWT), with the high kinesiophobia group performing worse (p < 0.05). Partial correlations showed a strong negative association between kinesiophobia and walking capacity (r = -0.608, p < 0.001). Hierarchical regression analyses revealed that kinesiophobia was a significant independent predictor of poorer motor function, reduced walking endurance, and decreased balance confidence (p < 0.05).Conclusions: Kinesiophobia negatively impacts motor symptoms and functional mobility in PD, beyond demographic and disease-related factors. Addressing the fear of movement in rehabilitation may improve physical function and reduce the risk of falls in this population.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rural inpatient hospitals and substance use-a 10-year retrospective analysis. 农村住院医院与药物使用——10年回顾性分析

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-30 DOI: 10.1007/s11845-025-04095-z

Sadie Lavelle-Cafferkey, Fintan Sheerin, Catherine Comiskey

{"title":"Rural inpatient hospitals and substance use-a 10-year retrospective analysis.","authors":"Sadie Lavelle-Cafferkey, Fintan Sheerin, Catherine Comiskey","doi":"10.1007/s11845-025-04095-z","DOIUrl":"https://doi.org/10.1007/s11845-025-04095-z","url":null,"abstract":"Aim: To determine the burden and nature of substance use presentations within a defined rural region and provide an estimate of the prevalence and subsequent local needs.Method: Anonymised secondary data, based on hospital inpatient enquiry (HiPE) records dated 2010-2021 from three sites, were analysed using descriptive and inferential statistics.Result: Despite similar gender distributions across the three hospitals, approximately 3:1 male to female, substance-related admissions varied significantly across hospitals (p < .001). Hospital C had the highest alcohol-related admissions 3537(98.6%), followed by Hospital A for opiates 369(12.3%) and Hospital B for cannabis 161 (2.2%). Only 1151(8.2%) of patients received substance use treatment. Discharge destinations also differed (p < .001), with Hospital A having higher patient transfer rates 301(10%) and self-discharge/absconding incidents 415(13.8%) compared to Hospitals B 261(3.6%) and 442(6%) and C 175(4.9%) and 200(5.6%) respectively. Alcohol-related disorders were among the top five non-communicable diseases for men across all sites, and for women in two of the three hospitals, indicating a widespread but gender-variable burden of alcohol-related harm.Discussion: The data demonstrates significant disparities in substance-related admissions, discharges, and treatment across the hospitals, highlighting the need for integrated care pathways, personalized services, and targeted professional development to address substance use presentations effectively. The findings underscore that a one-size-fits-all approach is insufficient.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of closed treatment for late-presentation developmental dysplasia of the hip. 闭合治疗晚期发育性髋关节发育不良的疗效。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-26 DOI: 10.1007/s11845-025-04083-3

Peggy E Miller, Timothy McAleese, Ross Condell, Joseph G O'Beirne

{"title":"Effectiveness of closed treatment for late-presentation developmental dysplasia of the hip.","authors":"Peggy E Miller, Timothy McAleese, Ross Condell, Joseph G O'Beirne","doi":"10.1007/s11845-025-04083-3","DOIUrl":"https://doi.org/10.1007/s11845-025-04083-3","url":null,"abstract":"Background: Developmental dysplasia of the hip (DDH) is the most common developmental musculoskeletal disorder. Late presentation of DDH is defined by a diagnosis made when a child is older than 3 months. Few studies evaluate the effectiveness of conservative management with bracing in this cohort.Aims: This study aimed to evaluate the effectiveness of nonoperative treatment, using the Pavlik harness and Boston brace, in patients presenting with developmental dysplasia of the hip (DDH) who commenced treatment following initial ultrasound scans done between 91 and 182 days (3 to 6 months). The secondary objective was to identify potential risk factors associated with treatment failure.Methods: We conducted a retrospective review of 54 such cases treated at our institution over a 7-year period. Various factors, including age at treatment initiation, gender, Graf classification and duration of treatment, were analysed.Results: Closed treatment was successful in 44 patients. Five remain under review. Four patients required closed reduction and subsequently progressed to pelvic osteotomy for residual dysplasia. One further patient had a pelvic osteotomy for residual dysplasia. The four patients who required closed reduction had all had Type III hips. Gender and age of commencement of treatment did not predict outcome.Conclusions: Our findings suggest that closed treatment with a Pavlik harness and/or Boston brace can still be an effective treatment strategy for late-presenting DDH. We found that treatment failure is more likely in more severely dysplastic hips.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research opportunities in precision oncology: perspectives on biospecimen and genomic data sharing from adults with cancer in Ireland. 在精确肿瘤学的研究机会：对生物标本和基因组数据共享的观点从成人癌症在爱尔兰。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-26 DOI: 10.1007/s11845-025-04082-4

Shane O'Grady, Jessica C Ralston, Eadaoin McKiernan, Frances J Drummond, Jan Rynne, Derick Mitchell, Isabella Bray, William M Gallagher, Amanda Drury, Walter Kolch

{"title":"Research opportunities in precision oncology: perspectives on biospecimen and genomic data sharing from adults with cancer in Ireland.","authors":"Shane O'Grady, Jessica C Ralston, Eadaoin McKiernan, Frances J Drummond, Jan Rynne, Derick Mitchell, Isabella Bray, William M Gallagher, Amanda Drury, Walter Kolch","doi":"10.1007/s11845-025-04082-4","DOIUrl":"https://doi.org/10.1007/s11845-025-04082-4","url":null,"abstract":"Background: Although surveys of people living with cancer in other nations have generally found a high degree of willingness to donate to research services such as genomic databases and biobanks, results may vary between countries. Additional questions also remain surrounding issues such as preferred model of consent, reporting of findings and concerns surrounding potential commercial application of health data.Methods: Data was gathered from 176 adults living with and beyond cancer in Ireland over a 16-month period, utilising an online survey platform. Descriptive statistics were used to characterise the survey cohort, with relationships between variables tested using the Spearman correlation or chi-square analysis.Results: Twenty-eight percent of respondents had previously donated a biological sample to research, while all those who had not previously donated indicated they would do so if given the opportunity. There was a strong preference for total transparency with personal health data, with the vast majority wanting to know of any risk factors identified in their genome, even if these risks were not medically actionable. Respondents held a high degree of trust in both the clinical and scientific community, with most indicating that this played a major role in influencing their decision to donate. Finally, while most did not have issues with commercial involvement in the donation process, 26% did express some reservations.Conclusion: Our results indicate a high degree of receptiveness to biological sample donation amongst people living with cancer in Ireland, suggesting that further efforts to recruit individuals could yield substantial improvements in sample donation rates.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: The Telehealth chain: a framework for secure and transparent telemedicine transactions on the blockchain. 撤回注：远程保健链：区块链上安全和透明的远程医疗交易框架。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-25 DOI: 10.1007/s11845-025-04091-3

Syed Sarosh Mahdi, Zaib Ullah, Gopi Battineni, Muneer Gohar Babar, Umer Daood

引用次数: 0

Beyond the bladder: Escherichia coli UTIs drive systemic inflammation and RANKL-mediated bone resorption. 膀胱外：大肠杆菌尿路感染驱动全身炎症和rankl介导的骨吸收。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-25 DOI: 10.1007/s11845-025-04093-1

Redha Dawud Abd Alredha, Krarr Haider Haddawi, Hussein Sattar Rebat Alzerfi

{"title":"Beyond the bladder: Escherichia coli UTIs drive systemic inflammation and RANKL-mediated bone resorption.","authors":"Redha Dawud Abd Alredha, Krarr Haider Haddawi, Hussein Sattar Rebat Alzerfi","doi":"10.1007/s11845-025-04093-1","DOIUrl":"https://doi.org/10.1007/s11845-025-04093-1","url":null,"abstract":"Background: Systemic inflammation associated with recurrent urinary tract infections (rUTIs) can adversely affect bone metabolism. This study aimed to explore the interactions between vitamin D status, inflammatory markers, and bone turnover in patients with rUTIs, with a focus on the differences between infections caused by Escherichia coli and those caused by non-E. coli pathogens.Methods: In this cross-sectional study, 50 patients with rUTIs (25 with E. coli-induced infections and 25 with infections caused by non-E. coli pathogens) were evaluated. The serum levels of 25-hydroxyvitamin D (vitamin D), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), receptor activator of nuclear factor kappa-Β ligand (RANKL), and the bone resorption marker C-terminal telopeptide of type I collagen (CTX-I) were measured. Statistical analyses included group comparisons, correlation assessments, receiver operating characteristic (ROC) curve analysis, and multiple linear regression.Results: Patients in the E. coli group had significantly lower serum vitamin D levels and elevated levels of IL-6, RANKL, and CTX-I than those in the non-E. coli group (all p < 0.001). Vitamin D levels showed a strong inverse correlation with RANKL levels (r = - 0.593). In the multiple regression analysis, IL-6 and RANKL emerged as the only independent predictors of CTX-I, collectively accounting for 60% of the variance (R2 = 0.60).Conclusion: Recurrent urinary tract infections caused by E. coli are associated with a clinical profile characterized by vitamin D deficiency and inflammation-mediated bone resorption driven by the IL-6/RANKL signaling pathway. These findings highlight the previously underappreciated osteoimmunological impact of common bacterial infections and suggest that skeletal health should be an important consideration in the management of patients with rUTIs.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating plasma phoenixin-14, galanin, galanin-like peptide, and spexin levels in polycystic ovary syndrome. 多囊卵巢综合征患者血浆凤凰素-14、甘丙肽、甘丙肽样肽和精浆蛋白水平的评价。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-24 DOI: 10.1007/s11845-025-04074-4

Meltem Yardim, Huseyin Fatih Gul, Ulku Ayse Turker Aras

{"title":"Evaluating plasma phoenixin-14, galanin, galanin-like peptide, and spexin levels in polycystic ovary syndrome.","authors":"Meltem Yardim, Huseyin Fatih Gul, Ulku Ayse Turker Aras","doi":"10.1007/s11845-025-04074-4","DOIUrl":"https://doi.org/10.1007/s11845-025-04074-4","url":null,"abstract":"Background: Impaired central neuropeptide production is implicated in polycystic ovary syndrome (PCOS).Aim: This study aimed to determine whether plasma phoenixin-14, galanin (GAL), galanin-like peptide (GALP), and spexin levels in women with PCOS were altered compared to those in non-PCOS controls.Methods: Sixty participants, including 30 patients diagnosed with PCOS and 30 healthy controls, were enrolled in this study. Phoenixin-14, GAL, GALP, and spexin levels were measured in plasma samples.Results: Although plasma phoenixin-14 levels in the PCOS group were significantly higher than those in the control group, spexin and GAL levels were significantly lower. No significant intergroup differences were observed in plasma GALP levels (p = 0.442). To distinguish PCOS from healthy controls, the area under the receiver operating characteristic (ROC) curve (AUC) of phoenixin-14 was 0.798, that of spexin was 0.757, and that of GAL was 0.702 (p < 0.001, p < 0.001, and p = 0.003, respectively). The AUC of the combined diagnostic value of the three peptides for PCOS was 0.910 (95%CI: 0.808-0.968) (p < 0.001), indicating a good diagnostic value.Conclusions: Plasma phoenixin-14, spexin, and GAL levels differed between patients with PCOS and controls. When combined, the three peptides exhibited better predictive performance than the individual peptides.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventions to improve adherence to clinical practice guidelines when treating cardiovascular disease: a systematic review. 在治疗心血管疾病时提高临床实践指南依从性的干预措施：一项系统综述

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-24 DOI: 10.1007/s11845-025-04057-5

Sarah McErlean, Louise McCollum, Mark Ledwidge, John Broughan, Geoff McCombe, Walter Cullen, Joe Gallagher

{"title":"Interventions to improve adherence to clinical practice guidelines when treating cardiovascular disease: a systematic review.","authors":"Sarah McErlean, Louise McCollum, Mark Ledwidge, John Broughan, Geoff McCombe, Walter Cullen, Joe Gallagher","doi":"10.1007/s11845-025-04057-5","DOIUrl":"https://doi.org/10.1007/s11845-025-04057-5","url":null,"abstract":"Background: Clinical practice guidelines have the potential to improve healthcare quality and safety in those with cardiovascular disease. However, guideline adherence is a challenge worldwide.Aims: We aim to determine the types and effects of interventions that target healthcare professionals to improve adherence to cardiovascular disease treatment guidelines-specifically for atrial fibrillation, ischaemic heart disease, heart failure, dyslipidaemia, and/or hypertension in ambulatory care.Methods: The following databases were searched from January 2012 to September 2023: MEDLINE, CINAHL, EMBASE,Cochrane, PsycINFO, ERIC International, Applied Social Sciences Index and Abstracts, clinicatrial.gov, and EUtrials. The search was supplemented by reviewing the reference lists of included studies, cited articles, and systematic reviews published in the field. Randomised trials, including cluster randomised trials and cross-over designs, were included. Two investigators independently extracted data and assessed study quality.Results: Forty-six studies examining the impact of healthcare-targeted interventions on improving guideline adherence were identified. Various approaches were employed, with educational interventions being the most frequently used. Given the heterogeneity in types of intervention and outcomes reported in the included trials, a narrative synthesis of the data was difficult, and meta-analysis was not planned.Conclusions: This review demonstrates that a diverse range of interventions aimed at healthcare professionals have the potential to improve adherence to CVD guidelines, but their overall effectiveness remains mixed. To narrow the gap between best practice and real-world guideline application, effective implementation strategies must become as important as guideline development itself.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mediating role of pain in the relationship between sleep and recovery. 疼痛在睡眠和恢复之间的中介作用。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-24 DOI: 10.1007/s11845-025-04097-x

Kadriye Aldemir Atmaca, Dilek Öztürk, Atiye Aydin

{"title":"The mediating role of pain in the relationship between sleep and recovery.","authors":"Kadriye Aldemir Atmaca, Dilek Öztürk, Atiye Aydin","doi":"10.1007/s11845-025-04097-x","DOIUrl":"https://doi.org/10.1007/s11845-025-04097-x","url":null,"abstract":"Backgraund: Sleep disturbances and pain are common in the early postoperative period and can significantly impact recovery. Poor sleep quality may increase pain perception, while unmanaged pain can further disrupt sleep, creating a negative cycle that impairs healing. Understanding how these factors interact is essential to improving postoperative outcomes.Aim: This study aims to examine the mediating role of pain in the relationship between sleep quality on the first postoperative night and the level of recovery.Methods: This descriptive and cross-sectional study was conducted with 250 patients who underwent laparoscopic cholecystectomy in the general surgery clinic of a university hospital. Data were collected using the Patient Information Form, the Richards-Campbell Sleep Questionnaire, the Quality of Recovery-40 Questionnaire, and the Visual Analogue Scale. For statistical analysis, Pearson correlation, regression, hierarchical regression, and bootstrap mediation analysis were performed.Results: Sleep quality was found to be a significant and positive predictor of recovery (β = 0.415, p < .001). However, when pain was included in the model, the effect of sleep quality decreased but remained significant (β = 0.130, p = .035). The results of the bootstrap mediation analysis confirmed that pain was a significant mediator in this relationship.Conclusion: Sleep quality influences postoperative recovery both directly and indirectly through pain levels. The findings suggest that holistic approaches to sleep and pain management in postoperative care processes may optimise recovery.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-dentistry unplugged: cutting waste and water for a greener practice. 不插电的生态牙科：减少浪费和用水，实现更环保的实践。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-23 DOI: 10.1007/s11845-025-04094-0

Mehwash Kashif, Anusha Ahmed, Asma Bint-E-Adil

引用次数: 0