Irish Journal of Medical Science最新文献_第3页

MEETING ABSTRACTS FROM THE 2024 UCD SCHOOL OF MEDICINE SUMMER STUDENT RESEARCH AWARDS (SSRA 2024). 会议摘要来自2024年ucd医学院暑期学生研究奖（ssra 2024）。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-07-01 DOI: 10.1007/s11845-025-03974-9

引用次数: 0

Combining CT radiomics and radiological features to predict pathological grade in stage I lung adenocarcinoma. 结合CT放射组学和影像学特征预测I期肺腺癌的病理分级。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-30 DOI: 10.1007/s11845-025-03993-6

Lu He, Chunhong Hu

{"title":"Combining CT radiomics and radiological features to predict pathological grade in stage I lung adenocarcinoma.","authors":"Lu He, Chunhong Hu","doi":"10.1007/s11845-025-03993-6","DOIUrl":"https://doi.org/10.1007/s11845-025-03993-6","url":null,"abstract":"Aims: While previous studies have explored the use of radiomics or radiological features alone, this study uniquely integrates both feature types within a unified predictive model based on the latest IASLC grading system, thereby enhancing pathological grading accuracy in early-stage invasive lung adenocarcinoma. This study aimed to evaluate the potential of combining CT radiomics with traditional radiological features to non-invasively predict the pathological grade of stage I invasive pulmonary adenocarcinoma according to the International Association for the Study of Lung Cancer (IASLC) new grading system.Methods: A retrospective study was conducted on 240 patients. Radiological features were assessed, and radiomics texture features were selected using mRMR and LASSO. A combined predictive model was constructed using random forest regression, and its diagnostic performance was evaluated using ROC analysis.Results: The CT radiological feature model achieved AUCs of 0.848 in the training set and 0.832 in the validation set. The texture feature model yielded AUCs of 0.850 in the training set and 0.845 in the validation set. The combined predictive model demonstrated superior diagnostic performance with AUCs of 0.902 in the training set and 0.880 in the validation set. The combined model's specificity also exceeded that of the individual models, with specificities of 90.5% and 93.3% in the training and validation sets, respectively.Conclusions: This model improved diagnostic accuracy and demonstrated strong potential for clinical application, advocating for its broader adoption in clinical practice to improve personalized treatment strategies in lung cancer care.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of psychotherapeutic interventions on pain and quality of life in endometriosis: a systematic review and meta-analysis study. 心理治疗干预对子宫内膜异位症患者疼痛和生活质量的影响：一项系统回顾和荟萃分析研究。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-28 DOI: 10.1007/s11845-025-03985-6

Handan Özcan, Ayşe Çuvadar, Sevda Uzun

{"title":"The effect of psychotherapeutic interventions on pain and quality of life in endometriosis: a systematic review and meta-analysis study.","authors":"Handan Özcan, Ayşe Çuvadar, Sevda Uzun","doi":"10.1007/s11845-025-03985-6","DOIUrl":"https://doi.org/10.1007/s11845-025-03985-6","url":null,"abstract":"Aim: This study aimed to determine the effect of psychotherapeutic interventions on pain, quality of life and health profile in women diagnosed with endometriosis.Methods: For this systematic review and meta-analysis study, studies were obtained by searching PubMed, Web of Science, EBSCOhost, Google Scholar, and YÖK Thesis Center databases between August and October 2024 without any year limitation. After the review, 10 studies were included in the study. The data were synthesized by meta-analysis and narrative methods.Results: In this systematic review and meta-analysis, psychotherapeutic interventions for the treatment and management of endometriosis were found to be effective on quality of life (SMD = 0.515, 95% CI = 0.035 to 0.995; Z = 2.104, I2 = 67.523%, p < 0.05), pain (SMD = - 0.454, 95% CI = - 1.600 to - 0.179; Z = - 1.566, I2 = 84.463, p > 0.05), and health profile (SMD = 0.041, 95% CI = - 0.363 to 0.281; Z = - 0.250759, I2 = 56.876%, p > 0.05). In subgroup analyses, it was determined that the types of psychotherapeutic interventions were not effective, but the number of sessions was effective.Conclusion: Psychotherapeutic interventions to reduce symptoms in endometriosis are effective in improving quality of life but not pain and health profile.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of stress perceived in clinical practice on professional behavior in nursing students: a correlational and descriptive study. 临床实践中压力感知对护生职业行为的影响：一项相关及描述性研究。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-27 DOI: 10.1007/s11845-025-03989-2

Nurten Gülsüm Bayrak, Elif Güzide Emirza

{"title":"The effect of stress perceived in clinical practice on professional behavior in nursing students: a correlational and descriptive study.","authors":"Nurten Gülsüm Bayrak, Elif Güzide Emirza","doi":"10.1007/s11845-025-03989-2","DOIUrl":"https://doi.org/10.1007/s11845-025-03989-2","url":null,"abstract":"Background: Perceived stress in clinical practice in nursing students affects their professional behaviors.Aims: Perceived stress in clinical practice in nursing students affects their professional behaviors. The study examined the effect of stress perceived by nursing students in clinical practice on professional behavior.Methods: The correlational and descriptive study population consisted of nursing students studying at a state university in northern Türkiye, and the sample consisted of 2nd, 3rd, and 4th year nursing students. \"Personal Information Form,\" \"Nursing Students Professional Behaviors Scale,\" and \"Perceived Stress Scale for Nursing Students\" forms and scales were used to collect the data. Descriptive statistics, Pearson correlation test, Mann-Whitney U test, Kruskall Wallis test, and linear regression analysis were used to analyze the data.Results: A significant relationship was found between perceived stress and professional behavior in nursing students who participated in the study. In addition, there was a significant relationship between the mean scores of gender, class, reason for choosing nursing, liking the nursing profession and clinical practice, and smoking variables and the mean scores of perceived stress and professional behavior. It was also concluded that perceived stress had a predictive effect on professional behavior and sub-dimensions (p < 0.005).Conclusions: This study revealed that perceived stress in nursing students is effective in professional care behavior. Thus, it provides essential findings for increasing stress management and professional behaviors in nursing education. In this context, improvements in educational processes and strengthening support mechanisms to reduce the negative effects of stress will contribute to the professional development of nursing students.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First-trimester inflammation and dyslipidemia in preterm delivery: the role of monocyte-to-HDL cholesterol ratio and lipid profiles. 妊娠早期炎症和早产中的血脂异常：单核细胞-高密度脂蛋白胆固醇比率和脂质谱的作用

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-23 DOI: 10.1007/s11845-025-03992-7

Didem Kaymak, Simge Berrak Beyoglu Oruc, Ebru Alıcı Davutoğlu

{"title":"First-trimester inflammation and dyslipidemia in preterm delivery: the role of monocyte-to-HDL cholesterol ratio and lipid profiles.","authors":"Didem Kaymak, Simge Berrak Beyoglu Oruc, Ebru Alıcı Davutoğlu","doi":"10.1007/s11845-025-03992-7","DOIUrl":"https://doi.org/10.1007/s11845-025-03992-7","url":null,"abstract":"Background: Preterm delivery (PTD) remains a leading cause of neonatal morbidity and mortality. Maternal inflammatory disturbances during early pregnancy may contribute to PTD pathogenesis. Alterations in lipid metabolism, particularly decreased high-density lipoprotein cholesterol (HDLc) and the HDLc-to-low-density lipoprotein cholesterol (HDLc/LDLc) ratio, alongside inflammatory markers such as the monocyte-to-HDLc ratio (MHR), have been associated with adverse pregnancy outcomes. However, their predictive role for PTD requires further investigation.Aim: This study aimed to evaluate the relationship between first-trimester maternal lipid profiles, HDLc, HDLc/LDLc ratio, and MHR, and the subsequent risk of PTD.Methods: A retrospective analysis was conducted on 152 pregnant women, including 53 PTD cases and 99 term deliveries. First-trimester complete blood counts and lipid profiles were assessed. MHR was calculated as the monocyte count divided by the HDLc level. Regression and correlation analyses evaluated associations, while receiver operating characteristic (ROC) curve analysis assessed MHR's predictive value for PTD.Results: PTD cases exhibited significantly lower HDLc levels and HDLc/LDLc ratios and higher MHR values (p < 0.05). HDLc showed a negative correlation with PTD risk (r = - 0.308, p = 0.000), while MHR correlated positively (r = 0.250, p = 0.002). ROC analysis identified an MHR cut-off of 0.0078 for PTD prediction (AUC = 0.652, 95% CI 0.562-0.741, p = 0.002).Conclusion: First-trimester elevated MHR and reduced HDLc levels may serve as early biomarkers for PTD risk, reflecting underlying inflammatory and metabolic dysregulation. Early assessment of MHR could enhance risk stratification and guide preventive strategies. Further studies are warranted to validate these findings.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the incision: assessing bleeding risks in early aspirin administration post coronary artery bypass grafting. 在切口之外：评估冠状动脉搭桥术后早期服用阿司匹林的出血风险。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-23 DOI: 10.1007/s11845-025-03990-9

Laura M Staunton, Sarah Early, Michael Tolan, Vincent K Young, Saleem M Jahangeer

{"title":"Beyond the incision: assessing bleeding risks in early aspirin administration post coronary artery bypass grafting.","authors":"Laura M Staunton, Sarah Early, Michael Tolan, Vincent K Young, Saleem M Jahangeer","doi":"10.1007/s11845-025-03990-9","DOIUrl":"https://doi.org/10.1007/s11845-025-03990-9","url":null,"abstract":"Background: Guidelines recommend early aspirin loading (150-325 mg) within 6 h of coronary artery bypass grafting (CABG), which improves patency of vein grafts. Due to bleeding concerns, this is not standard practice.Aims: The aim of this study is to review early aspirin administration, within 6 h of CABG, to determine if there is an increased risk of bleeding.Methods: Bleeding risk was evaluated in 160 patients, undergoing CABG procedure from January 2022 to February 2023. Patients were divided into two groups: those that received 300 mg of aspirin within 6 h (group 1) and those that did not (group 2). Drainage output from different timepoints, red cell, platelet transfusion rates, pericardial effusion, and re-exploration for bleeding were reviewed. Statistical analysis was performed using STATA/BE version 18.0. Significance was demonstrated when p value < 0.05.Results: Mean output drainage at 24 h was 695.7 mL for group 1 and 712.7 mL for group 2. Considering 11 timepoints, there were no significant difference between groups (p values = 0.731-0.117). Transfusion rates for red cells (p = 0.734) and platelets (p = 0.274), re-exploration for bleeding (p = 0.694), and pericardial effusion rates (p = 0.472) also showed no statistical difference.Conclusions: A comprehensive review of drainage output, red cell, platelet transfusion, re-exploration for bleeding, and pericardial effusion rates was performed, post early aspirin administration. Aspirin (300 mg) given within 6 h of CABG surgery did not lead to increased bleeding and associated complications.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive systematic review of prognostic factors, survival outcomes, and the role of targeted therapies in endometrial cancer. 对子宫内膜癌的预后因素、生存结果和靶向治疗的作用进行了全面系统的回顾。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-21 DOI: 10.1007/s11845-025-03984-7

Ali Raza, Rimsha Abaidullah, Fahad M Alshabrmi, Israr Fatima

{"title":"A comprehensive systematic review of prognostic factors, survival outcomes, and the role of targeted therapies in endometrial cancer.","authors":"Ali Raza, Rimsha Abaidullah, Fahad M Alshabrmi, Israr Fatima","doi":"10.1007/s11845-025-03984-7","DOIUrl":"10.1007/s11845-025-03984-7","url":null,"abstract":"Study background and objectives: Endometrial cancer, ranking as the 6th most prevalent cancer affecting women globally, is characterized by high mortality rates, recurrence, and poor prognosis. The disease lacks comprehensive understanding and effective treatment options. This meta-analysis focuses on randomized controlled trials to investigate targeted therapies, survival outcomes, and prognostic factors in endometrial cancer.Methods: The study follows the PICOS protocol and PRISMA guidelines, utilizing Review Manager Software (Version 5.4) for meta-analyses. Predetermined outcomes relevant to the topic guide the study search, with the GRADE tool assessing the quality of evidence and Begg's formula and Kendall's Tau evaluating certainty.Results: Results reveal oral anastrozole and vistusertib's efficacy, reducing progression-free survival (PFS) and enhancing protein detection. The meta-analysis indicates that targeted therapies do not significantly improve PFS but reduce adverse effects. Chemotherapy does not considerably improve survival rates, and interventions show no significant difference in prognostic factors.Conclusion: In conclusion, anastrozole and vistusertib emerge as effective targeted therapies for endometrial cancer, supported by clinical trial evidence demonstrating reduced PFS and improved protein detection. Additionally, the carboplatin-paclitaxel combination and radiotherapy in monotherapy show promising clinical outcomes. These findings contribute to a comprehensive understanding of prognostic factors, targeted therapies, and survival outcomes in endometrial cancer, emphasizing the need for further research and clinical trials for optimal disease management.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraosseous route is associated with prolonged epinephrine-to-ROSC interval in out-of-hospital cardiac arrest. 院外心脏骤停时，骨内途径与肾上腺素- rosc间期延长有关。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-21 DOI: 10.1007/s11845-025-03979-4

Michael W Hubble, Stephen Taylor, Melisa Martin, Sara Houston, Ginny R Kaplan, Randy D Kearns

{"title":"Intraosseous route is associated with prolonged epinephrine-to-ROSC interval in out-of-hospital cardiac arrest.","authors":"Michael W Hubble, Stephen Taylor, Melisa Martin, Sara Houston, Ginny R Kaplan, Randy D Kearns","doi":"10.1007/s11845-025-03979-4","DOIUrl":"10.1007/s11845-025-03979-4","url":null,"abstract":"Background: Prolonged resuscitation is associated with poor patient outcomes. While the importance of bystander CPR and early defibrillation is well-known, the role of other components affecting resuscitation duration is less well-established. We postulated that first-dose intraosseous (IO) epinephrine would prolong the pressor-to-ROSC interval compared to intravenous (IV) drug administration.Aims: To describe the relationship between first epinephrine administration route and pressor-to-ROSC intervals.Methods: A retrospective analysis of the 2020 ESO Data Collaborative Annual Research dataset was conducted among adults who experienced non-traumatic, bystander-witnessed arrests. A Cox proportional hazard model was used to determine the influence of first epinephrine route on the pressor-to-ROSC interval. End-of-event was defined as ROSC, field termination of resuscitation, or hospital arrival without ROSC, with right censoring of the latter group.Results: Overall, 9351 patients were included for analysis, of which 63.9% were males. The mean age of participants was 65.3(± 15.5) years and presumed cardiac etiology was present in 82.7% of arrests. An initial shockable rhythm was present in 27.1%, while 29.7% received bystander CPR and 39.7% attained ROSC. The mean pressor-to-ROSC interval was 13.21(± 9.65), 14.86 (± 10.89), and 14.42 (± 10.52) minutes for the intravenous, tibial IO, and humeral IO routes, respectively (p < 0.001). First epinephrine administration via the tibial or humeral IO route was associated with a decreased hazard of ROSC compared to the IV route (HR = 0.78, p < 0.001 and HR = 0.86, p = 0.01 per minute, respectively).Conclusions: These data suggest that the tibial and humeral IO routes of first epinephrine administration were associated with marginally prolonged resuscitation duration after drug administration and decreasing hazard of ROSC.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new electrocardiographic evaluation in hyperkalemia: frontal QRS-T angle. 一种新的高钾血症心电图评价方法：正面QRS-T角。

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-21 DOI: 10.1007/s11845-025-03988-3

Mustafa Yedigoz, Akkan Avci, Kemal Sener, Begum S Avci, Onder Yesiloglu, Ahmet B Urfalioglu, Erdem Aksay, Yeliz Simsek

{"title":"A new electrocardiographic evaluation in hyperkalemia: frontal QRS-T angle.","authors":"Mustafa Yedigoz, Akkan Avci, Kemal Sener, Begum S Avci, Onder Yesiloglu, Ahmet B Urfalioglu, Erdem Aksay, Yeliz Simsek","doi":"10.1007/s11845-025-03988-3","DOIUrl":"10.1007/s11845-025-03988-3","url":null,"abstract":"Introduction: ECG is a frequently used and easily accessible diagnostic tool used to evaluate cardiac involvement in hyperkalemia patients.Objective: The present study aimed to investigate the mortality prediction potential of the frontal QRS-T angle in hyperkalemia patients and the effects of the treatment process on this angle.Method: The study was planned as a prospective study. A total of 121 hyperkalemia patients were included in the study. Conditions that caused high potassium were identified and the PR, QRS, QT, QTc, and frontal QRS-T angle were calculated and recorded from the 12-lead ECG recordings of the patients at the time of admission to the emergency room.Results: The mean age of the patients was 58.5 ± 9.2 years (median: 59), 63 (% 52.1) were female and 58 (% 47.9) were male. The second measurements of the ECG parameters PR, QTc, QRS, T-amplitude, T duration, and frontal QRS-T values were lower than the first measurements (p < 0.001; p = 0.007; p < 0.001; p < 0.001; p < 0.001; p = 0.006, respectively). The ability of the patient's ECG parameters PR, QT, QTc, QRS, T-amplitude, frontal QRS-T angle, and frontal QRS-T (absolute value) to predict the development of mortality In the ROC Curve analysis, it was found that these parameters did not have a statistically significant effect in predicting mortality.Conclusion: As well as known ECG findings, in cases of hyperkalemia, widening of the frontal QRS-T angle and correction of this widened angle in patients with normokalemia detected with treatment can be used as an important follow-up parameter.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methanol poisoning in the emergency department: methanol blood levels, prognosis, and sequelae outcomes. 急诊科的甲醇中毒：甲醇血浓度、预后和后遗症

IF 1.7 4区医学

Irish Journal of Medical Science Pub Date : 2025-06-21 DOI: 10.1007/s11845-025-03982-9

Kürşat Sarıbaş, Ayça Açıkalın Akpınar, Pınar Efeoğlu Özşeker, Ömer Taşkın, Nezihat Rana Dişel, Gül Filiz Devecioğlu

{"title":"Methanol poisoning in the emergency department: methanol blood levels, prognosis, and sequelae outcomes.","authors":"Kürşat Sarıbaş, Ayça Açıkalın Akpınar, Pınar Efeoğlu Özşeker, Ömer Taşkın, Nezihat Rana Dişel, Gül Filiz Devecioğlu","doi":"10.1007/s11845-025-03982-9","DOIUrl":"10.1007/s11845-025-03982-9","url":null,"abstract":"Background: Methanol poisoning is a critical condition marked by severe metabolic acidosis, shock, and organ failure, often leading to high morbidity, mortality, and sequelae such as permanent blindness.Aims: This study retrospectively analyzes methanol poisoning cases to provide insights into diagnosis, treatment, outcomes, and sequelae rates.Methods: Patients diagnosed with methanol poisoning in a university-based emergency department between 2015 and 2023 were analyzed. Data on demographics, presenting complaints, diagnostics, treatments, hospitalization, outcomes, and sequelae were collected.Results: Among 116 patients, the mean age was 48.3 ± 13.5 years, and 94.8% (n = 110) were male. Alcohol poisoning accounted for 110 cases, while six involved other substances. Eighty-nine patients were discharged, and 27 died. Ocular findings predominated among survivors, while altered consciousness was the most common complaint in deceased patients. Deceased patients exhibited significantly lower pH and HCO3 levels and higher base deficit, anion gap, and lactate levels. Blood methanol levels (mean, 64.5 ± 79.9 mg/dL) showed no correlation with mortality. Treatments included hemodialysis (89.7%), hemofiltration (19.8%), ethyl alcohol (77.6%), fomepizole (15%), and NaHCO3 (78.1%). Visual sequelae developed in 33.7% of patients, while neurologic sequelae occurred in 6.2%.Conclusion: Methanol poisoning remains a severe clinical issue with high morbidity and mortality. Low pH, HCO3, and high anion/lactate levels are poor prognostic indicators. Early treatment improves outcomes, yet disabling visual sequelae are frequent. Developing rapid diagnostic kits for methanol and formic acid detection is essential for improving early diagnosis and management.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0