Irish Journal of Medical Science最新文献

{"title":"Evaluation of Ireland's Sugar-Sweetened Beverage Tax (SSBT).","authors":"Frank Houghton, Jennifer Moran Stritch, Jeremy Auerbach, Daisy Houghton, Mia Daly","doi":"10.1007/s11845-025-03906-7","DOIUrl":"https://doi.org/10.1007/s11845-025-03906-7","url":null,"abstract":"<p><strong>Background: </strong>Ireland is experiencing high levels of overweight and obesity. The adverse health impacts of excess weight include cancer, cardiovascular disease, diabetes, and dental decay, as well as a host of other conditions. In response, the Irish Government introduced a Sugar-Sweetened Beverage Tax (SSBT) in 2018.</p><p><strong>Aims: </strong>This research sought to explore the impact of Ireland's Sugar-Sweetened Beverage Tax.</p><p><strong>Method: </strong>Euromonitor International Ltd data for the years 2010 - 2022 detailing carbonated drinkrelated sugar consumption in Ireland was examined.</p><p><strong>Results: </strong>A gradual decline in sugar consumption via carbonated soft drinks was evident before the introduction of the SSBT in Ireland. However, in the first full year since the introduction of the SSBT, there was a marked 30.2% reduction in sugar intake via carbonates through retailers and a 19.8% reduction in sugar intake via carbonates via food service venues.</p><p><strong>Conclusions: </strong>The reduction in sugar intake via carbonates in the aftermath of the introduction of the SSBT was dramatic. However, it is unclear how much of this reduction was caused by industry reformulation of soft drinks and how much by consumers choosing lower-sugar or sugar-free soft beverages. Whatever the precise contribution of either factor, these results suggest that the SSBT has effectively reset national sugar consumption via soft drinks at a lower level.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audit of VTE prophylaxis prescribing preferences among orthopaedic consultants in Irish orthopaedic trauma centres.","authors":"Charles Timon, Conor Kilkenny, Nicola Byrne, John F Quinlan, Niall P McGoldrick","doi":"10.1007/s11845-025-03909-4","DOIUrl":"https://doi.org/10.1007/s11845-025-03909-4","url":null,"abstract":"<p><strong>Background: </strong>Thromboembolic complications are common in trauma orthopaedic practise. Despite extensive research, there remain a number of unanswered questions regarding the use of thromboprophylaxis.</p><p><strong>Aims: </strong>To establish the current practise among Irish consultant orthopaedic surgeons regarding thromboprophylaxis.</p><p><strong>Methods: </strong>A confidential online questionnaire regarding VTE prophylaxis was circulated to all consultant orthopaedic surgeons in training hospitals in the Republic of Ireland. Questions investigated surgeon awareness of local/national guidelines, inpatient and outpatient prescribing preferences and agreement/disagreement with the statement that defensive medicine, rather than evidence-based medicine, has driven increased emphasis on VTE prophylaxis in Ireland in recent years.</p><p><strong>Results: </strong>The response rate was 72% (69/96). 72% (50/79) of surgeons were aware of local VTE prophylaxis guidelines. 38% (29/96) were aware of national guidelines. 89% (62/69) routinely used mechanical prophylaxis modalities. 73.9% (51/69) routinely used chemical prophylaxis for inpatients. However, this practise was z extremely heterogenous with five other pharmacological agents used by the remainder. 82.6% (57/69) routinely discharged patients on extended duration chemical prophylaxis. 67% (46/69) agreed that the recent increased emphasis on VTE prophylaxis was due to defensive medicine and not evidence-based medicine.</p><p><strong>Conclusion: </strong>The results of this survey show that venous thromboembolism is regarded as a significant complication of orthopaedic surgery and most orthopaedic surgeons actively try to prevent it. There was a higher rate of intervention compared to previous surveys of Irish orthopaedic surgeons, possibly reflecting surgeon concerns regarding the high rate of litigation nationally. However, there is no consensus as to the optimum therapy which reflects the conflicting evidence available in the many publications on this subject.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of tele-nursing based motivational interviewing on self-efficacy, self-management and metabolic control parameters in individuals with type 2 diabetes: randomized controlled study.","authors":"Eda Kılınç İşleyen, İrem Nur Özdemir, Şengül Aydın Yoldemır","doi":"10.1007/s11845-025-03916-5","DOIUrl":"https://doi.org/10.1007/s11845-025-03916-5","url":null,"abstract":"<p><strong>Aim: </strong>The study was carried out to investigate the effect of tele-nursing based motivational interviewing on diabetes self-efficacy, self-management, and metabolic control parameters in individuals with Type 2 diabetes.</p><p><strong>Method: </strong>A parallel-group randomized controlled trial. The study was completed with 70 participants (intervention: 36; control: 34). The data were collected using the Socio-demographic and Health Related Questionnaire, the Diabetes Self-Efficacy Scale, the Diabetes Self-Management Scale. The intervention group received eight sessions tele-nursing based motivational interviewing. Instruments were administered to both groups before the intervention, at the end of the last motivational interviewing session (post-test, 3rd-month), and at 6th-month follow-up. The data were analyzed using chi-square test, independent sample t-test, and one-way ANOVA.</p><p><strong>Results: </strong>In the pre-test, there was no difference between the intervention and control groups in terms of independent variables (p > 0.05). Self-efficacy and self-management scores increased in the post-test and follow-up test of the group to which telenursing-based MI was applied, and there was a difference between the groups (p < 0.05). FBG and triglyceride levels of the intervention group decreased significantly in the post-test and follow-up test (FBG = 217.46 ± 73.88, 166.13 ± 50.71, and 161.41 ± 50.50, respectively; triglyceride = 225.28 ± 148.32, 159.68 ± 68.62, and 161.09 ± 73.06, respectively) (p < 0.05). HbA1c% level decreased significantly only in the post-test. However, no significant differences were found in terms of other metabolic parameters (p > 0.05).</p><p><strong>Conclusions: </strong>This result shows the positive effectiveness of tele-nursing based MI intervention on self-efficacy, self-management, HbA1c%, FBG, triglyceride. Public health nurses should be provided with tele-nursing based MI to individuals with type 2 diabetes in primary health care institutions.</p><p><strong>Study registration: </strong>The study was registered in ClinicalTrials NCT05628259 (prospective). Trial registration number and date of registration for prospectively registered trials. The study was registered in ClinicalTrials NCT05628259 (prospective). 2023-02-01.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different hemispheric gliomas on depression and prognosis in neurosurgery patients.","authors":"Kun Zhao, Jiakun Xu, Jiayu Gu, Beichuan Zhao","doi":"10.1007/s11845-025-03912-9","DOIUrl":"https://doi.org/10.1007/s11845-025-03912-9","url":null,"abstract":"<p><strong>Background: </strong>Depression is common in patients with gliomas, but few studies focused on the association between depression and glioma laterality.</p><p><strong>Aims: </strong>This study was purposed to investigate depression difference and prognostic value between patients with left-hemispheric gliomas and right-hemispheric gliomas.</p><p><strong>Methods: </strong>This study included 212 patients with left-hemispheric gliomas and 218 patients with right-hemispheric gliomas. Hospital Anxiety and Depression Scale (HADS) and Zung self-rating depression scale (SDS) were independently performed before surgery, 3 months and 6 months after surgery. All patients were followed up to death or 36 months. Overall survival (OS) and progression-free survival (PFS) were performed to evaluate the survival of glioma patients.</p><p><strong>Results: </strong>The preoperative prevalence and scores of depression in patients with left-hemispheric gliomas were higher than those in patients with right-hemispheric gliomas. But there were no differences in postoperative prevalence and scores of depression between patients with left-hemispheric gliomas and right-hemispheric gliomas. In patients with left-hemispheric gliomas or with right-hemispheric gliomas, the preoperative scores of depression were higher than postoperative scores of depression, whereas there was no difference in depression score between 3 months after surgery and 6 months after surgery. In addition, patients with right-hemispheric gliomas had better PFS and OS than patients with left-hemispheric gliomas.</p><p><strong>Conclusions: </strong>Patients with left-hemispheric gliomas are more likely to bring about depression than patients with right-hemispheric gliomas. Besides, patients with right-hemispheric gliomas are more likely to have better survival than patients with left-hemispheric gliomas. Surgery is considered as a useful treatment to alleviate depression of glioma patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital-based paediatric training for general practice trainees in Ireland.","authors":"Niamh Beirne, Jessica Klein, Michael O'Neill","doi":"10.1007/s11845-025-03904-9","DOIUrl":"https://doi.org/10.1007/s11845-025-03904-9","url":null,"abstract":"<p><strong>Background: </strong>Paediatric presentations represent 25% of General Practice consultations in Ireland [1]. The 'Under 6' GP scheme saw a further increase of 25% within paediatric consultations [2]. GP trainees spend 4 months on a dedicated paediatric rotation, representing 5.7% of the 4-year scheme.</p><p><strong>Aims: </strong>To establish trainee exposure to paediatric presentations during a summer-time rotation; and, whether such presentations satisfy the requirements of the GP curriculum, as it currently stands.</p><p><strong>Methods: </strong>A real-time observational study at Mayo University Hospital.</p><p><strong>Results: </strong>Five hundred paediatric patients presented to the PDU during the 7-week period within a summer-time rotation demonstrating a 45% reduction in opportunities for clinical encounters on a day-to-day basis as compared to a winter-time rotation. 72% (n = 41) of presentations currently listed on the GP curriculum were encountered by SHO-level NCHDs (n = 8) collectively, with each SHO seeing an average of 35.75 patients over a 7-week period (i.e. 5.1 per week, or 0.72 per day over a 7-day week), representing 57.2% of total presentations.</p><p><strong>Conclusion: </strong>GP paediatric teaching is experiential, opportunistic, and seasonal. The GP curriculum, as it relates to paediatrics, may benefit from relevant updates via modified Delphi study. Paediatric rotations could be bolstered by use of validated e-learning tools [3], audio-visual material and evidence-based simulation to develop diagnostic accuracy via deliberate practice without a clinical encounter.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary zinc intake amount and prevalence of osteoporosis in middle-aged and elderly individuals: a cross-sectional study.","authors":"Xiang Zhang, Jing Zhang, Lei Shen, Binbin Ni, Chenglong Wang","doi":"10.1007/s11845-025-03910-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03910-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study was aimed to explore the link between dietary zinc intake amount and prevalence of osteoporosis in middle-aged and elderly individuals.</p><p><strong>Methods: </strong>A total of 31,034 participants included in the National Health and Nutrition Examination Survey (NHANES) 2005-2010 were detected, and 7355 participants aged ≥ 45 years with integral data were enrolled. Demographic information and dietary intake data were collected via platform of NHANES, and the odds ratio (OR) and 95% confidence interval (CI) of each dietary zinc intake amount tertile category and each unit increase of zinc were analyzed using logistic regression models. Receiver operating characteristic (ROC) curve was applied to determine the optimal cut-off value of dietary zinc intake amount for revealing the prevalence of osteoporosis.</p><p><strong>Results: </strong>Of 7355 participants with a mean age of 62.5 ± 11.2 years, 682 participants with osteoporosis were identified, and the dietary zinc intake amount of the osteoporosis group was significantly lower than that of the non-osteoporosis group (P < 0.001). By taking the lowest tertile category as reference category, a higher dietary zinc intake amount was noticed to be positively linked to lower odds for prevalence of osteoporosis. This tendency was not altered in univariate model (P < 0.001), as well as the adjustments for combination of different covariates (Model 1, Model 2, Model 3, and Model 4, P all < 0.05).</p><p><strong>Conclusion: </strong>This NHANES-based study revealed that a lower dietary zinc intake amount was positively correlated to the prevalence of osteoporosis in middle-aged and elderly individuals among the US population.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A radiographic analysis of humerus shaft fractures to predict non-union.","authors":"Alexander Price, Conor O'Driscoll, Nicolaas Kotze, Danilo Vukanic, Petr Jemelik, May Cleary, David O'Briain","doi":"10.1007/s11845-025-03905-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03905-8","url":null,"abstract":"<p><strong>Background: </strong>Humeral shaft fracture non-union rates of up to 33% have been reported when managed non-operatively. When managed surgically, non-union rates of 10% have been seen. The initial radiographic displacement parameters may be of significance in determining whether non-operative treatment might fail.</p><p><strong>Aims: </strong>To determine whether the initial radiographic displacement of humeral shaft fractures can predict non-union rates and assist in decision-making for surgical intervention.</p><p><strong>Methods: </strong>A retrospective cohort study was performed to identify all patients with humeral shaft fractures presenting to a regional trauma centre over a three-year period. Three-observer measurements were taken on defined radiographic parameters. These were compared between groups treated successfully with surgery and with non-operative intervention. A subset group was identified who failed non-operative treatment and required delayed surgery. Statistical analysis was performed to determine whether the group that failed non-operative treatment met the proposed radiographic parameters predicting treatment failure.</p><p><strong>Results: </strong>Eighty patients were identified over the defined three-year period. Failure of non-operative management occurred in 6/43 (13.95%) patients. Failed conservative treatment was associated with increased age, female gender, and increased AP translation of lateral radiographs. Fractures successfully treated non-operatively showed a significantly lower AP translation on the lateral radiographs compared to patients who failed non-operative treatment 9.69 mm (IQR 4.90-14.05 mm) versus 22.61 mm (IQR 15.73-23.83 mm), p-value = 0.042.</p><p><strong>Conclusion: </strong>Significant initial AP displacement may be associated with failure of non-operative management. This study highlights the importance of initial radiographic parameters of displacement in predicting possible failure of non-operative management for midshaft humerus fractures.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between psoriasis and subclinical atherosclerosis defined by carotid intima-media thickness (CIMT) in patients with psoriasis vulgaris: a systematic review and meta-analysis.","authors":"Maryam Yousefi, Pouyan Shakeri, Azin Tahvildari, Hossein Salehi Omran, Sara Sharifi, Mohammad A Shafiee","doi":"10.1007/s11845-025-03875-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03875-x","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a chronic inflammatory condition that increases the risk of vascular issues, ranging from mild artery damage to severe events such as heart attacks and strokes. This systematic review and meta-analysis aimed to evaluate the relationship between psoriasis and carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis.</p><p><strong>Methods: </strong>A comprehensive search of Embase, PubMed/Medline, Scopus, and CINAHL via EBSCO was conducted up until June 2023 using the terms \"Atherosclerosis AND Psoriasis.\" Studies measuring CIMT to assess atherosclerosis in psoriasis patients were included. A meta-analysis and subgroup analysis were performed to calculate the overall mean difference in CIMT between psoriasis patients and control groups. Studies published between 2009 and 2023 were reviewed, including 28 case-control, 18 cross-sectional, and two prospective cohort studies.</p><p><strong>Results: </strong>The total sample size was 15,914 participants, with individual study sizes ranging from 32 to 8271. Of the included studies, 44 revealed a significant association between psoriasis and CIMT, suggesting a higher risk of subclinical atherosclerosis in psoriasis patients. The meta-analysis found that psoriasis patients had a CIMT 0.17 mm higher than the control group (95% CI 0.12- 0.22). However, six studies did not show a statistically significant mean difference.</p><p><strong>Conclusions: </strong>This study emphasizes the importance of assessing cardiovascular risk in psoriasis patients, particularly those with moderate-to-severe disease. It highlights the need for tailored interventions to manage the increased risk of atherosclerosis in this population.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHLPP and LAMP2 predict favorable treatment response and survival in multiple myeloma patients who receive induction treatment with bortezomib.","authors":"Qingkun Han, Wei Han, Cuiping Li, Qianqian Xie, Xuebing Jing","doi":"10.1007/s11845-025-03879-7","DOIUrl":"https://doi.org/10.1007/s11845-025-03879-7","url":null,"abstract":"<p><strong>Objective: </strong>Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) increases the sensitivity of multiple myeloma (MM) cells to bortezomib by upregulating lysosome-associated membrane protein 2 (LAMP2), while their clinical role in MM patients is unclear. This study aimed to assess the intercorrelation between PHLPP and LAMP2, as well as their associations with treatment response and survival in MM patients who received induction treatment with bortezomib.</p><p><strong>Methods: </strong>A total of 59 MM patients who received induction treatment with bortezomib were included. PHLPP and LAMP2 were detected by quantitative polymerase chain reaction in bone marrow plasma cells that were collected before treatment. Treatment response, progression-free survival (PFS), and overall survival (OS) were assessed.</p><p><strong>Results: </strong>PHLPP was positively correlated with LAMP2, whether they were considered as continuous variables (r = 0.469, P < 0.001) or categorized as high and low expressions (P = 0.003). PHLPP and LAMP2 were elevated in patients who achieved complete remission (CR) versus those who did not, as well as in patients who achieved partial remission (PR) and above versus those who had less than PR (all P < 0.05). By chi-square test, high PHLPP (cut by the median) was linked with the achievement of PR and above (P = 0.015), and high LAMP2 (cut by the median) was related to the achievement of CR (P = 0.030). High PHLPP (P = 0.016) and LAMP2 (P = 0.037) were associated with prolonged PFS, but not OS (both P > 0.05).</p><p><strong>Conclusion: </strong>PHLPP is positively correlated with LAMP2, and their high expressions predict favorable treatment response and PFS in MM patients who receive induction treatment with bortezomib.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-144-3p participates in the regulation of gestational diabetes mellitus by targeting FOXO1.","authors":"Meiyi Chen, Shaomeng Sun, Lei Ma, Li Bian, Biao Zhao, Haiyong Zeng","doi":"10.1007/s11845-025-03894-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03894-8","url":null,"abstract":"<p><strong>Background: </strong>The pivotal role of microRNAs (miRNAs) in the pathogenesis of gestational diabetes mellitus (GDM) have been increasingly highlighted in recent studies.</p><p><strong>Aims: </strong>To investigate miR-144-3p expression in patients with GDM and its potential mechanisms in GDM.</p><p><strong>Methods: </strong>According to the inclusion criteria, 98 pregnant women with GDM and 98 normal pregnant women were statistically selected. The levels of miR-144-3p were determined by RT-qPCR. The ROC curve was used to evaluate the diagnostic value of miR-144-3p for GDM. Pearson analysis was used to analyze the correlation. HRT-8/SVneo cells were induced by high glucose in vitro to mimic the high glucose environment of GDM. On this basis, the cell models of miR-144-3p overexpression and knockdown were established to investigate the potential mechanism of miR-144-3p in GDM.</p><p><strong>Results: </strong>The level of miR-144-3p in GDM group was markedly higher than that in normal pregnant women. In terms of predicting GDM, miR-144-3p demonstrated high accuracy. MiR-144-3p was positively linked to blood glucose markers in GDM. Further investigation has confirmed that miR-144-3p harbors a binding site for FOXO1 and can directly modulate its expression. Moreover, miR-144-3p targeted FOXO1 to affect the proliferation of trophoblast cells.</p><p><strong>Conclusion: </strong>The expression of miR-144-3p is elevated in pregnant women with GDM. MiR-144-3p may be involved in the regulation of GDM by targeting FOXO1.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}