Irish Journal of Medical Science最新文献

{"title":"Digital habits and physical health: a study of screen time and BMI among young healthcare profession students and residents.","authors":"Hooria Rahim, Bilal Ahmad, Khoban Rahim, Zainab Fatima, Ayesha Humayun, Hafiza Asma Nazir, Arzoo Rahim, Maryam Shafiq, Eman Azam, Muhammad Usman","doi":"10.1007/s11845-025-03991-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03991-8","url":null,"abstract":"<p><strong>Background: </strong>Average screen time has increased drastically after the COVID-19 pandemic. It has raised concerns about the adverse effects, including the effect on BMI.</p><p><strong>Aim: </strong>The present study is conducted to study the relationship between screen time and BMI among medical students at a medical institute in Lahore, Pakistan.</p><p><strong>Methods: </strong>For this cross-sectional study, a sample of 370 medical students and residents was obtained from a medical institute in Pakistan. An online survey to gather data about screen time activities, device usage, and BMI. Screen time was categorized into low (1-2 h/day), moderate (3-4 h/day), and high (5-6 h/day), while BMI score was calculated and categorized into under-weight, normal, overweight, and obese groups. Descriptive and inferential statistics including Spearman correlation analysis were applied using IBM SPSS 25.0.</p><p><strong>Results: </strong>Most participants fell into the normal BMI category (79%), with a smaller proportion classified as overweight (16%) or obese (5%). Most participants preferred using smartphones (92.1%). About 41% of participants had high screen time. There was a strong positive correlation between low screen time and normal BMI (r = 0.999). However, only 2.9% of the participants had low screen time. The link between higher screen time and obesity is observed especially in males, while females maintain a more stable normal weight, suggesting gender-based lifestyle or metabolic differences.</p><p><strong>Conclusion: </strong>Screen time is significantly associated with BMI with a strong positive correlation as well. There is need to design educational programs to raise awareness about the safe use of devices and the amount of screen time.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of visual evoked potentials latency and amplitude to be a subclinical predictor of clinical prognosis in multiple sclerosis.","authors":"Elif Banu Soker, Miray Erdem, Derya Ozdogru, Onur Serdar Gencler, Onder Yesiloglu, Halit Fidanci","doi":"10.1007/s11845-025-03980-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03980-x","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal demyelinating lesions, axonal dysfunction/degeneration, and gliosis, which can lead to various clinical disabilities. Visual evoked potentials (VEP) is sensitive and repeatable techniques capable of monitoring significant short-term changes in neuroaxonal integrity and alterations in nerve conduction triggered by acute optic neuritis.</p><p><strong>Aim: </strong>This study aims to evaluate whether VEP latency and amplitude could serve as subclinical predictors of clinical outcomes in MS patients over short-term follow-ups.</p><p><strong>Methods: </strong>This study was planned to include MS patients diagnosed according to the McDonald Criteria 18 who did not have any psychiatric, neurological, or ocular disorders that could interfere with the main purpose. The VEP test was performed for routine evaluation of demyelination or axonal damage.</p><p><strong>Results: </strong>A total of 83 patients were included in the study, with a mean age of 33.6 ± 9.3 years. Of all the patients, 54 were female (65.1%) and 29 were male (34.9%). Right pattern reversal visual evoked potential (PVEP) P100 (OR for PVEP1: 0.802, p = 0.001; OR for PVEP2: 0.879, p = 0.002) was statistically significant in showing right VEP abnormality at both baseline and at 6 months. Left VEP abnormalities were associated with left PVEP P100 at PVEP1 (OR: 0.852, p = 0.003) and left PVEP N75 at PVEP2 (OR: 0.935, p = 0.029).</p><p><strong>Conclusion: </strong>VEPs have the potential to predict short-term subclinical stability or progression, making them valuable candidates for early treatment adjustments and evaluating future pharmacotherapy-supported remyelination.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-lymphocyte ratio: is it more valuable than CRP in assessing severity of acute diverticulitis at initial presentation? A single-center retrospective cohort study.","authors":"Nurettin Sahin, Ahmet Surek, Turgut Donmez, Ferman Tevfik Ozyalvac, Emine Ayca Sahin, Sina Ferahman, Halil Kirazkaya, Muge Yurdacan, Mahmut Said Degerli, Sezer Bulut, Hamit Ahmet Kabuli, Alpen Yahya Gumusoglu","doi":"10.1007/s11845-025-03983-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03983-8","url":null,"abstract":"<p><strong>Aim: </strong>We aim to evaluate the effectiveness of cheap, easily accessible, and simple biomarkers in determining the severity of diverticulitis according to the modified Hinchey classification.</p><p><strong>Method: </strong>Patients were divided into two groups: complicated and uncomplicated diverticulitis. Laboratory test results of the two groups were compared. The same patients were divided into two groups: operated and non-operated patients. Laboratory test results of these two groups were compared.</p><p><strong>Results: </strong>The study included 335 patients. Two hundred twenty patients (65.7%) were classified as having uncomplicated diverticulitis, and 115 patients (34.3%) were classified as having complicated diverticulitis. For CRP, the sensitivity was 53.9%, and the specificity was 69.1% in distinguishing between complicated and uncomplicated diverticulitis patients [AUC 0.648 (0.587-0.709)]. For NLR, the sensitivity was 80.9%, and the specificity was 58.6% [AUC 0.734 (0.678-0.791)]. Forty-nine patients (14.6%) were classified as having operated diverticulitis, and 286 patients (85.4%) were classified as having non-operated diverticulitis. For NLR, the sensitivity was 84.5%, and the specificity was 65.0% in distinguishing between operated and non-operated diverticulitis patients [AUC 0.789 (0.728-0.850)]. For CLR, the sensitivity was 85.7% and the specificity was 53.5% [AUC 0.735(0.664-0.805)].</p><p><strong>Conclusion: </strong>In patients with acute diverticulitis, the NLR value is more successful than the CRP value in distinguishing between complicated and uncomplicated diverticulitis. Similarly, it can effectively predict whether patients with acute diverticulitis will require surgery. In addition, the CLR value predicts the need for surgery in patients with acute diverticulitis with high sensitivity.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes towards stress urinary incontinence surgery in Ireland: navigating the pause on mid-urethral sling use.","authors":"Reut Rotem, Muireann Hickey, Daniel Galvin, Suzanne O'Sullivan, Ciaran Brady, Orfhlaith E O'Sullivan","doi":"10.1007/s11845-025-03986-5","DOIUrl":"https://doi.org/10.1007/s11845-025-03986-5","url":null,"abstract":"<p><strong>Background: </strong>Mid-urethral slings (MUS) for the surgical management of stress urinary incontinence (SUI) have been suspended in Ireland since July 2018, significantly impacting treatment options and clinical practice.</p><p><strong>Aims: </strong>This study aimed to explore the attitudes of consultant obstetricians, gynaecologists, and urologists in Ireland toward SUI surgery following the MUS suspension, including their prior practices, current approaches, and views on MUS safety and potential reinstatement.</p><p><strong>Methods: </strong>A descriptive, anonymized questionnaire was electronically distributed in early 2023 to consultant members of the Irish Society of Urology and the Continence Foundation of Ireland. Non-consultants, non-medical professionals, and respondents outside Ireland were excluded. Data were analyzed using SPSS v28.</p><p><strong>Results: </strong>Before the 2018 suspension, 89.5% (17/19) of respondents performed SUI surgeries, with 76.5% (13/17) using MUS-retropubic and 53% (9/17) MUS-transobturator techniques. Post-suspension, 63.2% (12/19) continued performing SUI surgery, primarily urethral bulking (83.3%, 10/12). Regarding safety, 83.3% (15/18) believed MUS led to fewer instances of post-operative voiding dysfunction and 66.7% (12/18) reported fewer complications such as vault prolapse or rectocele. Notably, 44.4% (8/18) had been involved in litigation related to MUS. Despite this, 52.6% (10/19) expressed willingness to resume MUS if the suspension was lifted.</p><p><strong>Conclusions: </strong>MUS was the preferred SUI procedure prior to suspension due to perceived safety and effectiveness. Over half of consultants surveyed would consider resuming its use, highlighting a need for diverse, evidence-based treatment options and calling for a re-evaluation of the current suspension.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative proteinuria as a novel biomarker for predicting postoperative renal insufficiency after nephrectomy for renal cell carcinoma: a systematic review and meta-analysis.","authors":"Qiankun Xu, Huilan Zheng, Fanchao Zeng, Bin Li, Deliang Huang, Qiang Cai, Zhizhao Yang, Peng Wu","doi":"10.1007/s11845-025-03987-4","DOIUrl":"https://doi.org/10.1007/s11845-025-03987-4","url":null,"abstract":"<p><strong>Background: </strong>Identifying reliable predictors of postoperative renal insufficiency (PRI) following partial or radical nephrectomy for renal cell carcinoma (RCC) is critical for optimizing perioperative management.</p><p><strong>Methods: </strong>We systematically searched MEDLINE, Cochrane Library, and Embase up to March 20, 2025, to identify cohort studies that evaluated the association between preoperative proteinuria and PRI. We calculated pooled odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were stratified by study design (prospective vs. retrospective) and surgical modality (partial vs. radical nephrectomy).</p><p><strong>Results: </strong>Six cohort studies involving 3124 patients were included. Preoperative proteinuria was significantly associated with an increased risk of PRI (OR = 2.69, 95% CI 1.48-4.89; I² = 67.3%). We found that retrospective studies showed a stronger association between preoperative proteinuria and PRI (OR = 3.35, 95% CI 1.71-6.56) compared to prospective studies (OR = 1.89, 95% CI 0.98-3.66). Subgroup analysis by surgical approach revealed significant risk elevation in both partial nephrectomy (OR = 2.11, 95% CI 1.34-3.33) and radical nephrectomy cohorts (OR = 5.50, 95% CI 4.31-7.02), with a notably higher effect size in the latter.</p><p><strong>Conclusion: </strong>Preoperative proteinuria is significantly associated with an elevated risk of PRI in patients undergoing nephrectomy for renal cell carcinoma. These findings emphasize the need to incorporate proteinuria assessment into preoperative risk evaluations to improve patient counselling and perioperative management. Future high-quality prospective studies, particularly multicenter investigations with standardized protocols, are essential to confirm these associations and explore the pathophysiological mechanisms underlying proteinuria-related renal functional decline.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of short-term home-based exercise training via video call in older adults with physically inactive and sedentary life.","authors":"Fazıl Kulakli, İlker İlhanli, İlker Fatih Sari","doi":"10.1007/s11845-025-03981-w","DOIUrl":"https://doi.org/10.1007/s11845-025-03981-w","url":null,"abstract":"<p><strong>Objectives: </strong>Investigating the physical and mental effects of short-term exercise program and motivation with video communication methods such as telephone and internet applications on physically inactive and sedentary older adult's daily lives.</p><p><strong>Methods: </strong>Thirty participants were reached by video calling method. Participants were evaluated twice before and after the program. A 6-min walk test (6MWT), Barthel index for activities of daily living, Tinetti performance oriented mobility assessment (Tinetti POMA) and Geriatric depression scale (GDS) were applied. The standard daily exercise program was applied to all participants for 1 week. Exercise programs were created as endurance, strengthening, stretching and balance exercises.</p><p><strong>Results: </strong>All participants (16 female and 14 male) completed the program. In terms of 6MWT, Tinetti POMA and GDS, a statistically significant improvement was found after the program compared to the pre-program (p < 0.001, p < 0.001 and P < 0.001, respectively).</p><p><strong>Conclusions: </strong>It is possible and effective to organize exercise programs and to follow these with distance video calling applications in physically inactive and sedentary older adults.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can artificial intelligence generate scientific discussion that passes peer review for publication in a high-impact orthopaedic journal?","authors":"Gerard A Sheridan, Lisa C Howard, Michael E Neufeld, Tom R Doyle, Andrew J Hughes, Peter K Sculco, David E Beverland, Donald S Garbuz, Bassam A Masri","doi":"10.1007/s11845-025-03971-y","DOIUrl":"https://doi.org/10.1007/s11845-025-03971-y","url":null,"abstract":"<p><strong>Background: </strong>There is huge interest in the use of artificial intelligence (AI) in the production and assessment of academic material; however, the role of AI remains unclear.</p><p><strong>Aim: </strong>The purpose of this study was to perform a reviewer-blinded assessment of the quality of scientific discussion generated by an advanced AI language model (ChatGPT-4, Open AI) and determine whether this could be recommended for high-impact journal publication.</p><p><strong>Methods: </strong>The introduction, methods and results sections of a recently published article from a high-impact journal were input into a current AI model. The AI application then produced a discussion and conclusion based on the provided text using a standardized prompt. Six experienced blinded reviewers scored all five sections of the hybrid article. A one-way analysis of variance (ANOVA) was used to assess significant differences between scores of each section. Reviewers recommended a decision regarding the suitability of the article for publication.</p><p><strong>Results: </strong>AI composed a scientific discussion and conclusion. The median score was 80 (IQR 70-90) for introduction, 77.5 (IQR 70-90) for methods, 82.5 (IQR 50-90) for results, 60 (IQR 40-75) for discussion and 60 (IQR 40-80) for the conclusion. The median scores for the AI-generated sections were non-significantly lower than other sections (p = 0.37). The majority of reviewers (5/6, 83%) recommended \"acceptance for publication after major revision\". One reviewer recommended \"resubmission with no guarantee of acceptance\". There were no recommendations for rejection.</p><p><strong>Conclusion: </strong>Current AI large language models are now capable of generating content that passes experienced peer review and is acceptable for publication in a high-impact orthopaedic journal, after revision. There are still many concerns regarding the integration of AI into the process of scientific writing, mainly the tendency of AI to rely on advanced pattern recognition and fabricated or inadequate references.</p><p><strong>Level of evidence: </strong>Level IV.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of potential prothrombotic state markers in Behçet's disease and correlation with vascular ultrasound.","authors":"Hazan Karadeniz, Tunjay Mammadov, Mahi Nur Cerit, Rıza Can Kardas, Aslıhan Avanoglu Guler, Derya Yıldırım, Ibrahim Vasi, Hatice Pasaoglu, Abdulsamet Erden, Hamit Kucuk, Berna Goker, Mehmet Akif Ozturk, Abdurrahman Tufan","doi":"10.1007/s11845-025-03972-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03972-x","url":null,"abstract":"<p><strong>Objective: </strong>The study aims to evaluate the relationship between prothrombotic soluble serum levels of P-selectin, citrullinated histone H3 (CitH3), and growth differentiation factor-15 (GDF-15) and the thickness measurements of the carotid artery, femoral, portal, and jugular veins in patients with Behçet's disease (BD).</p><p><strong>Methods: </strong>Fifty-six BD patients who met the International Study Group criteria and 19 healthy control subjects were enrolled. We compared the groups' differences in B-mode ultrasound findings and biochemical prothrombotic markers. Logistic regression was used to analyze independent factors influencing thrombosis, and a receiver operating characteristic curve was plotted.</p><p><strong>Results: </strong>A total of 34 non-vascular and 22 vascular BD patients (mean age 41.5 ± 11.8 years, 38 (67.9%) male) were included in the study. No significant differences were observed between patients and healthy controls (HCs) in terms of sex, age, and body mass index. BD patients had elevated serum levels of P-selectin, CitH3, and GDF-15 compared to HCs (p < 0.05). CitH3 and GDF-15 levels were significantly higher in BD patients with vascular involvement than those without vascular disease (p < 0.05). The GDF-15 level in vascular BD patients showed a significant correlation with femoral vein thickness.</p><p><strong>Conclusion: </strong>GDF-15 and CitH3 are potential biomarkers that show vascular involvement and thrombosis in BD.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation and impact of a virtual educational intervention for parents of fussy eaters.","authors":"Edel McNamara, Elaine Guinan","doi":"10.1007/s11845-025-03968-7","DOIUrl":"https://doi.org/10.1007/s11845-025-03968-7","url":null,"abstract":"<p><strong>Background: </strong>Fussy eating is generally outgrown but can cause parental anxiety and disrupt family mealtimes. Parental anxiety may lead to coercive feeding practices, which may prolong the period of fussy eating. This project aimed to assess the feasibility and acceptability of delivering first-line advice for the management of fussy eating via a webinar delivered by dietitians.</p><p><strong>Methods: </strong>A descriptive observational design was used to evaluate the feasibility and impact of a monthly educational webinar for parents on fussy eating in children. Content was developed by community dietitians based on established guidelines and feedback from paediatric dietitians and parents. The education webinar was delivered via Zoom 13 times over the course of a year, with recruitment through health centres, social media, and schools. Data was collected through Eventbrite, Zoom analytics, and participant feedback forms. Quantitative data was analysed in Excel, and qualitative responses were thematically analysed for key themes.</p><p><strong>Results: </strong>Over 3300 (n 3334) people registered for the webinar. Attendance numbers per webinar increased from 23 people in July 2023 to 480 people in June 2024. On average, 34% of those who registered attended the monthly webinar. The majority (95%) of attendees remained online for the duration of the webinar. Of 346 feedback responses, 84% would recommend the webinar, 70% felt reassured, and 73% planned to adjust their practices. Thematic analysis revealed key takeaway messages for viewers: reducing mealtime stress, increasing food exposure, reassurance on fussy eating as a phase, fostering positive mealtime environments, and practical strategies.</p><p><strong>Conclusions: </strong>This service evaluation showed that delivery of first-line advice from dietitians on the management of fussy eating via webinar was feasible and acceptable to parents who attended.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of IL-17 and IL-23 ınhibitors on hematological ınflammatory parameters in patients with psoriasis vulgaris.","authors":"Mehmet Semih Çelik, Hamza Aktaş","doi":"10.1007/s11845-025-03969-6","DOIUrl":"https://doi.org/10.1007/s11845-025-03969-6","url":null,"abstract":"<p><strong>Background and objective: </strong>IL-17 and IL-23 inhibitors are widely used as biological agents in patients with psoriasis vulgaris to suppress inflammation and reduce disease severity. This study aimed to examine changes in inflammatory parameters, including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic inflammation index (SII), platelet/hemoglobin ratio (PHR), and red cell distribution width/platelet ratio (RPR), as well as the Psoriasis Area and Severity Index (PASI), in psoriasis patients receiving biological therapy (IL-17 and IL-23 inhibitors).</p><p><strong>Materials and methods: </strong>This retrospective study included 110 patients with psoriasis vulgaris treated with IL-23 (risankizumab, guselkumab or IL-17 inhibitors ( secukinumab, and ixekizumab). Disease severity was assessed using the PASI score. Hematological parameters (NLR, PLR, SII, PHR, and RPR) and PASI values of the patients were recorded and analyzed at baseline (month 0) and during treatment (month 6).</p><p><strong>Results: </strong>A significant decrease was observed in NLR, SII, and PHR values during treatment. NLR decreased significantly from 2.43 ± 1.25 at baseline to 2.12 ± 0.81 at month 6 (p = 0.002). Both IL-17 and IL-23 groups significantly reduced NLR (p = 0.044, p = 0.029, respectively). SII decreased significantly from 695 ± 390 at baseline to 588 ± 288 at month 6 (p = 0.002). Both groups significantly reduced SII levels (p = 0.044, p = 0.018, respectively).PHR decreased significantly from 19.8 ± 6.60 at baseline to 19.2 ± 6.58 at month 6 (p = 0.033).PASI score significantly decreased during treatment (p < 0.001).</p><p><strong>Conclusion: </strong>The significant reduction in NLR and SII levels in both the IL-17 and IL-23 groups suggests that these markers may be used together rather than separately in treatment follow-up. The significant decrease in PHR levels may indicate that IL-17 and IL-23 inhibitors contribute to reducing cardiovascular disease risk in patients with psoriasis vulgaris and promote a favorable long-term prognosis.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}