Irish Journal of Medical Science最新文献_第4页

The relationship between osteoporosis and sarcopenia parameters in postmenopausal women under 60 years of age: A cross-sectional study. 60岁以下绝经后妇女骨质疏松症与肌肉减少症参数的关系：一项横断面研究。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-22 DOI: 10.1007/s11845-025-04090-4

Büşra Şirin Ahısha, Nur Kesiktaş

{"title":"The relationship between osteoporosis and sarcopenia parameters in postmenopausal women under 60 years of age: A cross-sectional study.","authors":"Büşra Şirin Ahısha, Nur Kesiktaş","doi":"10.1007/s11845-025-04090-4","DOIUrl":"https://doi.org/10.1007/s11845-025-04090-4","url":null,"abstract":"Objective: This study aimed to determine the prevalence of sarcopenia in postmenopausal women under the age of 60 and to evaluate the relationship between sarcopenia, bone mineral density (BMD), and clinical parameters.Materials and methods: This cross-sectional study included 52 postmenopausal women under the age of 60, classified as osteoporotic or non-osteoporotic based on DXA results. Sarcopenia was assessed using the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). Muscle strength was measured using handgrip strength and the five-time sit-to-stand test (5STS), and muscle mass was assessed with the Tanita BC-418MA device. Skeletal muscle mass indices (SMMI) were calculated based on height2, weight, and BMI.Results: Fat-free mass (FFM), skeletal muscle mass (SMM), and SMM/height2 values were significantly lower in the osteoporotic group compared to the non-osteoporotic group (p < 0.05). No significant differences were found between the groups in handgrip strength or 5STS results. Sarcopenia prevalence varied depending on the muscle index used: 17.3% based on SMM/BMI (23.1% in the osteoporotic group, 11.5% in the non-osteoporotic group), 11.5% based on SMM/weight (3.8% vs. 19.2%), and 3.8% based on SMM/height2 (equal in both groups). These differences were not statistically significant (p > 0.05). Femoral neck and lumbar BMD and T-scores showed positive correlations with FFM and SMM, but not with muscle strength tests.Conclusion: In our study, sarcopenia prevalence did not significantly differ between osteoporotic and non-osteoporotic postmenopausal women under 60. However, the lower muscle mass observed in the osteoporotic group may indicate early structural changes associated with sarcopenia. The lack of difference in functional capacity suggests that these changes may not yet be clinically apparent.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of radial extracorporeal shock wave and kinesio taping on pain, quality of life, hand function and ultrasonographic measurement of median nerve cross-sectional area in patients with carpal tunnel syndrome: a single-blind randomized controlled trial. 桡骨体外冲击波和运动贴敷对腕管综合征患者疼痛、生活质量、手部功能和正中神经横断面积超声测量的影响：一项单盲随机对照试验。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-20 DOI: 10.1007/s11845-025-04084-2

Nazif Bilicier, Selda Çiftci İnceoğlu, Aylin Ayyıldız, Enes Efe İş, Banu Kuran

{"title":"Effects of radial extracorporeal shock wave and kinesio taping on pain, quality of life, hand function and ultrasonographic measurement of median nerve cross-sectional area in patients with carpal tunnel syndrome: a single-blind randomized controlled trial.","authors":"Nazif Bilicier, Selda Çiftci İnceoğlu, Aylin Ayyıldız, Enes Efe İş, Banu Kuran","doi":"10.1007/s11845-025-04084-2","DOIUrl":"https://doi.org/10.1007/s11845-025-04084-2","url":null,"abstract":"Background: Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the upper extremity. Treatment includes various conservative methods.Aims: This study investigated the effects of radial extracorporeal shockwave therapy (rESWT) and kinesio taping (KT), alone and combined, compared to exercise therapy on pain, quality of life, hand function, and ultrasonographic median nerve cross-sectional area (CSA) in CTS.Methods: Patients with mild to moderate CTS were randomized into four groups: Group 1 (rESWT + KT), Group 2 (rESWT), Group 3 (KT), and Group 4 (exercise only). The first three groups received weekly treatments for 3 weeks. Assessments included pain (NRS), neuropathic complaints (DN-4), grip/lateral pinch strength, symptom severity (BCTQ, DHI), quality of life (NHP), and median nerve CSA. Evaluations were conducted pre-treatment, at week 3 and week 6.Results: Seventy-six patients were included. Pain and paresthesia VAS scores significantly improved in all treatment groups (p < 0.05). BCTQ-SSS, grip strength, and lateral pinch strength improved significantly in Groups 1-3 compared to Group 4 (p < 0.05). CSA decreased significantly in Groups 1-3 (p < 0.05), with no differences between them. DHI and DN-4 scores improved in all groups (p < 0.05). NHP scores improved significantly only in Group 1 (p < 0.05).Conclusion: rESWT and KT, alone or combined, effectively improve pain, function, and CSA in CTS. Their combination is superior to exercise therapy alone.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgeon-guided transversalis fascia plane block vs. trocar site wound infiltration in pediatric laparoscopic appendectomy. 外科医生引导下横筋膜平面阻滞与套管针部位伤口浸润在小儿腹腔镜阑尾切除术中的应用。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-19 DOI: 10.1007/s11845-025-04088-y

Ozgur Caglar, Binali Firinci, Yusuf Alper Kara, Ali Ahiskalioglu

{"title":"Surgeon-guided transversalis fascia plane block vs. trocar site wound infiltration in pediatric laparoscopic appendectomy.","authors":"Ozgur Caglar, Binali Firinci, Yusuf Alper Kara, Ali Ahiskalioglu","doi":"10.1007/s11845-025-04088-y","DOIUrl":"https://doi.org/10.1007/s11845-025-04088-y","url":null,"abstract":"Background: Postoperative pain remains a significant concern in pediatric patients undergoing laparoscopic appendectomy. The transversalis fascia plane block (TFPB) is a recently described regional technique. In this study, we aimed to adapt this block into a laparoscopy-assisted approach and compare its analgesic efficacy with conventional wound infiltration in pediatric appendectomy.Methods: In this prospective, randomized controlled trial, 60 pediatric patients undergoing laparoscopic appendectomy were allocated to receive either laparoscopy-assisted TFPB (n = 30) or standard wound infiltration (WI; n = 30) with 0.25% bupivacaine (0.5 mL/kg). The primary outcome was postoperative pain evaluated via the FLACC (Face, Legs, Activity, Cry, Consolability) scale at seven time points within 24 h. Secondary outcomes included paracetamol consumption and parental satisfaction.Results: Demographic and perioperative variables were comparable between groups (p > 0.05). Paracetamol was required in significantly fewer patients in the TFPB group (36.7% vs 66.7%, p = 0.038), with fewer requiring repeated doses (13.3% vs 46.7%, p = 0.041). Although FLACC pain scores were statistically comparable between groups (p > 0.05), the TFPB group consistently showed lower median values from the fourth postoperative hour onward. Likewise, parental satisfaction was consistently high in both cohorts, with no significant variation between the analgesic techniques (p = 0.788). No adverse effects or block-related complications were reported.Conclusion: Laparoscopy-assisted TFPB significantly reduced postoperative analgesic requirements compared to wound infiltration. Given its feasibility, efficacy, and safety, laparoscopy-assisted TFPB technique should be considered an alternative component of multimodal analgesia in pediatric laparoscopic abdominal surgery.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do all superheroes wear capes? A case-control study of the highest grossing superhero movies. 所有的超级英雄都穿斗篷吗？对票房最高的超级英雄电影的病例对照研究。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-19 DOI: 10.1007/s11845-025-04080-6

Naykky M Singh Ospina, Andrew Simpkin, Spyridoula Maraka, Derek T O'Keeffe

{"title":"Do all superheroes wear capes? A case-control study of the highest grossing superhero movies.","authors":"Naykky M Singh Ospina, Andrew Simpkin, Spyridoula Maraka, Derek T O'Keeffe","doi":"10.1007/s11845-025-04080-6","DOIUrl":"https://doi.org/10.1007/s11845-025-04080-6","url":null,"abstract":"Objectives: The main goal of this study was to determine the frequency of cape use among superheroes and predictors of superhero status.Design: Observational case-control study where superheroes were considered cases and villains/neutral characters controls.Setting: Top 25 highest grossing superhero movies.Participants: Main characters in superhero movies classified as superheroes and villains through a multi-tier systems including videographic review and information collected in a superhero community database.Main outcome measures: Frequency of different attributes between superheroes/villains (e.g., cape wearing), correlation of attributes and univariate and multivariable adjusted models of attributes associated with a superhero status.Results: There were 97 observations of 68 characters over 25 movies from three studios. There were 61 observations of superheroes and 36 villains and neutrals. Just 16% of superheroes wore capes, while 11% of non-superheroes did so. The majority (67%) of superheroes were humans, while among non-superheroes were 56%. Almost all superheroes had an altruistic mission (98%), while this attribute was present in just 19% of non-superheroes.Conclusions: In a sample of characters from the highest grossing superhero movies, most superheroes did not wear a cape. The strongest predictor for a superhero status was having an altruistic mission.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal microvascular changes in pediatric patients with thromboembolism: an optical coherence tomography angiography study. 儿童血栓栓塞患者视网膜微血管改变：一项光学相干断层扫描血管造影研究。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-18 DOI: 10.1007/s11845-025-04086-0

Berkay Kızıltaş, Metin Çil

{"title":"Retinal microvascular changes in pediatric patients with thromboembolism: an optical coherence tomography angiography study.","authors":"Berkay Kızıltaş, Metin Çil","doi":"10.1007/s11845-025-04086-0","DOIUrl":"https://doi.org/10.1007/s11845-025-04086-0","url":null,"abstract":"Background: Microvascular changes in the retina can be detected in children with thromboembolism. These changes in the retina can be measured with optical coherence tomography angiography (OCTA).Aim: This study aims to evaluate retinal microvascular changes in pediatric patients who have experienced central nervous system thromboembolic events using OCTA.Methods: This cross-sectional study included 36 children aged 7-16 years. Comprehensive ophthalmic evaluations, including OCTA imaging using the AngioVue system, were performed. Retinal vascular density (VD), retinal thickness, and foveal avascular zone (FAZ) parameters were evaluated in predefined macular regions. Radial peripapillary capillary vessel density (RPCVD) and retinal nerve fiber layer (RNFL) thickness were also measured.Results: Compared to the control group, patients with thromboembolism exhibited a significant reduction in vascular density across all sectors of the deep capillary plexus (p < 0.05). Additionally, a significant decrease in vascular density was noted in the nasal sector of the superficial capillary plexus (p < 0.05). No significant difference was observed in the FAZ area between the groups (p > 0.05). RNFL thickness was significantly lower in all sectors in the patient group (p < 0.05). In contrast, peripapillary RPCVD was significantly higher in the patient group compared to the control group (p < 0.05).Conclusion: OCTA enables the noninvasive detection of retinal microvascular alterations in pediatric patients with thromboembolism. These findings highlight the early vascular involvement associated with the disease and may serve as a valuable tool for clinical monitoring and follow-up.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of perceptions on artificial intelligence in surgery: a survey study among surgeons and medical students in Ireland. 对外科手术中人工智能认知的比较分析：爱尔兰外科医生和医学生的调查研究。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-18 DOI: 10.1007/s11845-025-04079-z

Doris Braunstein, Haniya Farooq, Marco Paolino, Alice Moynihan, Ronan A Cahill

{"title":"Comparative analysis of perceptions on artificial intelligence in surgery: a survey study among surgeons and medical students in Ireland.","authors":"Doris Braunstein, Haniya Farooq, Marco Paolino, Alice Moynihan, Ronan A Cahill","doi":"10.1007/s11845-025-04079-z","DOIUrl":"https://doi.org/10.1007/s11845-025-04079-z","url":null,"abstract":"Background: Artificial Intelligence (AI) promises to revolutionize healthcare but has been previously characterized by cycles of \"boom\" and \"bust.\" Alongside technological capability, realistic user expectations are essential for appropriate implementation. We surveyed surgeons, surgical trainees, and medical students in Ireland regarding their current perceptions.Methods: Electronic survey distributed through professional networks and social media with institutional ethical approval. Statistical and thematic analyses were performed to identify key perspectives.Results: Among 94 participants (63% medical students, 18% surgical trainees, 15% consultants, and 4% ancillary surgical roles), 62.7% \"strongly agreed\" that AI could enhance real-time decision-making during surgery. Most (90.5%) believed AI was already being surgically deployed to some extent although only 18% felt it appropriate ever to use for decision-making. While 53.2% were positive about AI's potential to improve surgical outcomes, 72.3% reported no AI training in this context despite 86.2% expressing interest. The primary concerns with AI regarded accuracy and reliability (38.7%) and the lack of evidence of effectiveness (33.7%). Surgical trainees expressed greater concern about AI transparency (47% \"extremely concerned\") compared to consultants (42.9% \"slightly concerned\") and, along with students, declared higher concern regarding liability issues versus consultants (64.3% of whom had \"little to no concern\").Conclusion: Students and postgraduates in surgery in Ireland express optimism and high expectations for AI's potential to improve surgery. However, concerns about reliability, evidence, and liability persist with clear caution regarding automated decision-making and insight regarding the need for education that may help align expectations realistically regarding AI evolution.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Irish Radium Institute: the Royal Dublin Society and the promotion of radioactive therapy in twentieth-century Ireland. 爱尔兰镭研究所：皇家都柏林学会和二十世纪爱尔兰放射治疗的推广。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-17 DOI: 10.1007/s11845-025-04035-x

Adrian Kirwan

引用次数: 0

Direct anterior approach surgeons significantly overstate the benefits of this approach relative to other surgeons: a view of online promotion in Ireland, Australia, New Zealand and the UK. 直接前路外科医生明显夸大了这种方法相对于其他外科医生的好处：爱尔兰，澳大利亚，新西兰和英国在线推广的观点。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-16 DOI: 10.1007/s11845-025-04076-2

Eoghan Pomeroy, Gerard A Sheridan, Mark Curtin, Evelyn P Murphy

{"title":"Direct anterior approach surgeons significantly overstate the benefits of this approach relative to other surgeons: a view of online promotion in Ireland, Australia, New Zealand and the UK.","authors":"Eoghan Pomeroy, Gerard A Sheridan, Mark Curtin, Evelyn P Murphy","doi":"10.1007/s11845-025-04076-2","DOIUrl":"https://doi.org/10.1007/s11845-025-04076-2","url":null,"abstract":"Background: Growing patient interest in the direct anterior approach (DAA) has led to increased Internet promotion by surgeons.Aims: The aim of this study was to investigate Internet promotion of the DAA by surgeons in Australia, New Zealand, Ireland and the UK. Further, we aimed to determine if surgeons offering the DAA discussed the potential benefits of the approach more frequently than other surgeons.Methods: Orthopaedic surgeons were identified from the websites of the Australian Orthopaedic Association, New Zealand Orthopaedic Association, UK National Joint Registry, and Irish Institute of Trauma and Orthopaedic Surgery. Each surgeon website was investigated for claims made regarding the risks and benefits of the DAA, as well as the literature used to support these claims.Results: In total, 6.4% (n = 177) of websites identified mentioned the DAA: 128 (72.3%) websites were associated with surgeons offering the DAA, while 49 (27.7%) websites were associated with surgeons not offering the DAA. Potential benefits were mentioned in 74% of websites, while 36.7% made reference to risks; 9% cited peer-reviewed literature. When comparing websites of surgeons who offer the DAA with the websites of surgeons who do not, there was a statistically significantly increased rate of mentioning any benefit (p = 0.016), less tissue damage (p = 0.041), less blood loss (p = 0.004), faster recovery (p = 0.004), and fewer dislocations (p = 0.002).Conclusion: A small number of surgeons in these countries promote the DAA online. Surgeons offering the DAA are more likely to report the potential benefits of the procedure than surgeons not offering the DAA.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecological associations between gastric acid suppressant use and gastrointestinal cancer incidence: a three-decade global study. 胃酸抑制剂使用与胃肠道癌症发病率之间的生态关联：一项30年的全球研究。

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-13 DOI: 10.1007/s11845-025-04085-1

Khalid Orayj

{"title":"Ecological associations between gastric acid suppressant use and gastrointestinal cancer incidence: a three-decade global study.","authors":"Khalid Orayj","doi":"10.1007/s11845-025-04085-1","DOIUrl":"https://doi.org/10.1007/s11845-025-04085-1","url":null,"abstract":"Background: Gastric acid suppressants, including proton pump inhibitors (PPIs) and histamine H2-receptor antagonists, are widely used globally. Their long-term safety remains a concern, particularly regarding gastrointestinal cancer risks.Aims: To assess population-level associations between gastric acid suppressant use and the incidence of major gastrointestinal cancers, adjusting for potential confounders.Methods: This ecological panel study analyzed country-year data from 24 nations (1990-2020). Consumption of acid suppressants (ATC A02B, DDD/1000/day) was obtained from OECD Health Statistics. Age-standardized cancer incidence rates (colorectal, liver, pancreatic, esophageal) were sourced from the GBD 2019 dataset. Multivariable linear mixed-effects models were adjusted for dietary risks, BMI, tobacco, alcohol, antibiotics, NSAIDs, and GDP per capita.Results: Higher acid suppressant use was significantly associated with increased liver cancer (β = 0.0086; 95% CI 0.0019 to 0.0154; p = 0.0136) and pancreatic cancer (β = 0.0148; 95% CI 0.0068 to 0.0227; p = 0.0004) incidence. No significant associations were found for colorectal or esophageal cancers. Model fit was strongest for liver and pancreatic outcomes.Conclusions: While causal inference cannot be drawn from ecological data, the findings suggest a population-level association between gastric acid suppressant consumption and increased liver and pancreatic cancer incidence. These results support the need for cautious prescribing and further research using individual-level data.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of SGLT-2 inhibitors on liver stiffness in patients with diabetes mellitus and heart failure: a Fibroscan study. SGLT-2抑制剂对糖尿病和心力衰竭患者肝僵硬的影响：一项纤维扫描研究

IF 1.6 4区医学

Irish Journal of Medical Science Pub Date : 2025-09-13 DOI: 10.1007/s11845-025-04087-z

Huseyin Ali Ozturk, Hilmi Erdem Sumbul

{"title":"The effect of SGLT-2 inhibitors on liver stiffness in patients with diabetes mellitus and heart failure: a Fibroscan study.","authors":"Huseyin Ali Ozturk, Hilmi Erdem Sumbul","doi":"10.1007/s11845-025-04087-z","DOIUrl":"https://doi.org/10.1007/s11845-025-04087-z","url":null,"abstract":"Aim: Studies have shown an increase in liver stiffness (LS) by liver elastography in patients with type 2 diabetes mellitus (DM) and regression of LS in patients receiving SGLT-2 inhibitors (SGLT-2i). We aimed to investigate liver stiffness and related factors before and after treatment with SGLT-2i in patients with diabetes and heart failure.Methods: In our prospective and cross-sectional study, 237 patients with diabetes were included. Patients were divided into 3 groups according to the presence and status of heart failure. Patients were treated with SGLT-2i, and their pre- and post-treatment status was evaluated. LS measurements were performed with FibroScan® Mini 430 device (Echosens, France).Results: NT-proBNP levels decreased significantly in all groups, with the most pronounced reduction in the HFrEF group (p < 0.001). Liver stiffness (kPa) also improved significantly in all groups, with the greatest change observed in the HFrEF group (Δ = 2.11 ± 1.1 kPa, p < 0.001). Similarly, HbA1c levels showed marked reductions across all groups, with the highest improvement seen in the group without heart failure (Δ = 1.28 ± 0.63%, p < 0.001).Conclusion: Our findings reinforce the potential of SGLT-2i therapy to improve liver stiffness and related metabolic and cardiac parameters in diabetic patients, irrespective of heart failure status.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0