Retinal microvascular changes in pediatric patients with thromboembolism: an optical coherence tomography angiography study.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2025-09-18 DOI:10.1007/s11845-025-04086-0

Berkay Kızıltaş, Metin Çil

{"title":"Retinal microvascular changes in pediatric patients with thromboembolism: an optical coherence tomography angiography study.","authors":"Berkay Kızıltaş, Metin Çil","doi":"10.1007/s11845-025-04086-0","DOIUrl":null,"url":null,"abstract":"Background: Microvascular changes in the retina can be detected in children with thromboembolism. These changes in the retina can be measured with optical coherence tomography angiography (OCTA).Aim: This study aims to evaluate retinal microvascular changes in pediatric patients who have experienced central nervous system thromboembolic events using OCTA.Methods: This cross-sectional study included 36 children aged 7-16 years. Comprehensive ophthalmic evaluations, including OCTA imaging using the AngioVue system, were performed. Retinal vascular density (VD), retinal thickness, and foveal avascular zone (FAZ) parameters were evaluated in predefined macular regions. Radial peripapillary capillary vessel density (RPCVD) and retinal nerve fiber layer (RNFL) thickness were also measured.Results: Compared to the control group, patients with thromboembolism exhibited a significant reduction in vascular density across all sectors of the deep capillary plexus (p < 0.05). Additionally, a significant decrease in vascular density was noted in the nasal sector of the superficial capillary plexus (p < 0.05). No significant difference was observed in the FAZ area between the groups (p > 0.05). RNFL thickness was significantly lower in all sectors in the patient group (p < 0.05). In contrast, peripapillary RPCVD was significantly higher in the patient group compared to the control group (p < 0.05).Conclusion: OCTA enables the noninvasive detection of retinal microvascular alterations in pediatric patients with thromboembolism. These findings highlight the early vascular involvement associated with the disease and may serve as a valuable tool for clinical monitoring and follow-up.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Irish Journal of Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11845-025-04086-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Microvascular changes in the retina can be detected in children with thromboembolism. These changes in the retina can be measured with optical coherence tomography angiography (OCTA).

Aim: This study aims to evaluate retinal microvascular changes in pediatric patients who have experienced central nervous system thromboembolic events using OCTA.

Methods: This cross-sectional study included 36 children aged 7-16 years. Comprehensive ophthalmic evaluations, including OCTA imaging using the AngioVue system, were performed. Retinal vascular density (VD), retinal thickness, and foveal avascular zone (FAZ) parameters were evaluated in predefined macular regions. Radial peripapillary capillary vessel density (RPCVD) and retinal nerve fiber layer (RNFL) thickness were also measured.

Results: Compared to the control group, patients with thromboembolism exhibited a significant reduction in vascular density across all sectors of the deep capillary plexus (p < 0.05). Additionally, a significant decrease in vascular density was noted in the nasal sector of the superficial capillary plexus (p < 0.05). No significant difference was observed in the FAZ area between the groups (p > 0.05). RNFL thickness was significantly lower in all sectors in the patient group (p < 0.05). In contrast, peripapillary RPCVD was significantly higher in the patient group compared to the control group (p < 0.05).

Conclusion: OCTA enables the noninvasive detection of retinal microvascular alterations in pediatric patients with thromboembolism. These findings highlight the early vascular involvement associated with the disease and may serve as a valuable tool for clinical monitoring and follow-up.

查看原文本刊更多论文

儿童血栓栓塞患者视网膜微血管改变：一项光学相干断层扫描血管造影研究。

背景：视网膜微血管的改变可以在儿童血栓栓塞中检测到。视网膜的这些变化可以通过光学相干断层扫描血管造影（OCTA）来测量。目的：本研究旨在利用OCTA评估发生中枢神经系统血栓栓塞事件的儿童患者的视网膜微血管变化。方法：本横断面研究包括36名7-16岁儿童。进行全面的眼科评估，包括使用AngioVue系统进行OCTA成像。在预定的黄斑区域评估视网膜血管密度（VD）、视网膜厚度和中央凹无血管区（FAZ）参数。测量桡动脉乳头周围毛细血管密度（RPCVD）和视网膜神经纤维层厚度（RNFL）。结果：与对照组相比，血栓栓塞患者深毛细血管丛各部分血管密度显著降低（p < 0.05）。结论：OCTA能够无创检测儿童血栓栓塞患者视网膜微血管改变。这些发现强调了与疾病相关的早期血管受累，并可能作为临床监测和随访的有价值的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.