Irish Journal of Medical Science最新文献

{"title":"Effects of different hemispheric gliomas on depression and prognosis in neurosurgery patients.","authors":"Kun Zhao, Jiakun Xu, Jiayu Gu, Beichuan Zhao","doi":"10.1007/s11845-025-03912-9","DOIUrl":"https://doi.org/10.1007/s11845-025-03912-9","url":null,"abstract":"<p><strong>Background: </strong>Depression is common in patients with gliomas, but few studies focused on the association between depression and glioma laterality.</p><p><strong>Aims: </strong>This study was purposed to investigate depression difference and prognostic value between patients with left-hemispheric gliomas and right-hemispheric gliomas.</p><p><strong>Methods: </strong>This study included 212 patients with left-hemispheric gliomas and 218 patients with right-hemispheric gliomas. Hospital Anxiety and Depression Scale (HADS) and Zung self-rating depression scale (SDS) were independently performed before surgery, 3 months and 6 months after surgery. All patients were followed up to death or 36 months. Overall survival (OS) and progression-free survival (PFS) were performed to evaluate the survival of glioma patients.</p><p><strong>Results: </strong>The preoperative prevalence and scores of depression in patients with left-hemispheric gliomas were higher than those in patients with right-hemispheric gliomas. But there were no differences in postoperative prevalence and scores of depression between patients with left-hemispheric gliomas and right-hemispheric gliomas. In patients with left-hemispheric gliomas or with right-hemispheric gliomas, the preoperative scores of depression were higher than postoperative scores of depression, whereas there was no difference in depression score between 3 months after surgery and 6 months after surgery. In addition, patients with right-hemispheric gliomas had better PFS and OS than patients with left-hemispheric gliomas.</p><p><strong>Conclusions: </strong>Patients with left-hemispheric gliomas are more likely to bring about depression than patients with right-hemispheric gliomas. Besides, patients with right-hemispheric gliomas are more likely to have better survival than patients with left-hemispheric gliomas. Surgery is considered as a useful treatment to alleviate depression of glioma patients.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital-based paediatric training for general practice trainees in Ireland.","authors":"Niamh Beirne, Jessica Klein, Michael O'Neill","doi":"10.1007/s11845-025-03904-9","DOIUrl":"https://doi.org/10.1007/s11845-025-03904-9","url":null,"abstract":"<p><strong>Background: </strong>Paediatric presentations represent 25% of General Practice consultations in Ireland [1]. The 'Under 6' GP scheme saw a further increase of 25% within paediatric consultations [2]. GP trainees spend 4 months on a dedicated paediatric rotation, representing 5.7% of the 4-year scheme.</p><p><strong>Aims: </strong>To establish trainee exposure to paediatric presentations during a summer-time rotation; and, whether such presentations satisfy the requirements of the GP curriculum, as it currently stands.</p><p><strong>Methods: </strong>A real-time observational study at Mayo University Hospital.</p><p><strong>Results: </strong>Five hundred paediatric patients presented to the PDU during the 7-week period within a summer-time rotation demonstrating a 45% reduction in opportunities for clinical encounters on a day-to-day basis as compared to a winter-time rotation. 72% (n = 41) of presentations currently listed on the GP curriculum were encountered by SHO-level NCHDs (n = 8) collectively, with each SHO seeing an average of 35.75 patients over a 7-week period (i.e. 5.1 per week, or 0.72 per day over a 7-day week), representing 57.2% of total presentations.</p><p><strong>Conclusion: </strong>GP paediatric teaching is experiential, opportunistic, and seasonal. The GP curriculum, as it relates to paediatrics, may benefit from relevant updates via modified Delphi study. Paediatric rotations could be bolstered by use of validated e-learning tools [3], audio-visual material and evidence-based simulation to develop diagnostic accuracy via deliberate practice without a clinical encounter.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary zinc intake amount and prevalence of osteoporosis in middle-aged and elderly individuals: a cross-sectional study.","authors":"Xiang Zhang, Jing Zhang, Lei Shen, Binbin Ni, Chenglong Wang","doi":"10.1007/s11845-025-03910-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03910-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study was aimed to explore the link between dietary zinc intake amount and prevalence of osteoporosis in middle-aged and elderly individuals.</p><p><strong>Methods: </strong>A total of 31,034 participants included in the National Health and Nutrition Examination Survey (NHANES) 2005-2010 were detected, and 7355 participants aged ≥ 45 years with integral data were enrolled. Demographic information and dietary intake data were collected via platform of NHANES, and the odds ratio (OR) and 95% confidence interval (CI) of each dietary zinc intake amount tertile category and each unit increase of zinc were analyzed using logistic regression models. Receiver operating characteristic (ROC) curve was applied to determine the optimal cut-off value of dietary zinc intake amount for revealing the prevalence of osteoporosis.</p><p><strong>Results: </strong>Of 7355 participants with a mean age of 62.5 ± 11.2 years, 682 participants with osteoporosis were identified, and the dietary zinc intake amount of the osteoporosis group was significantly lower than that of the non-osteoporosis group (P < 0.001). By taking the lowest tertile category as reference category, a higher dietary zinc intake amount was noticed to be positively linked to lower odds for prevalence of osteoporosis. This tendency was not altered in univariate model (P < 0.001), as well as the adjustments for combination of different covariates (Model 1, Model 2, Model 3, and Model 4, P all < 0.05).</p><p><strong>Conclusion: </strong>This NHANES-based study revealed that a lower dietary zinc intake amount was positively correlated to the prevalence of osteoporosis in middle-aged and elderly individuals among the US population.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A radiographic analysis of humerus shaft fractures to predict non-union.","authors":"Alexander Price, Conor O'Driscoll, Nicolaas Kotze, Danilo Vukanic, Petr Jemelik, May Cleary, David O'Briain","doi":"10.1007/s11845-025-03905-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03905-8","url":null,"abstract":"<p><strong>Background: </strong>Humeral shaft fracture non-union rates of up to 33% have been reported when managed non-operatively. When managed surgically, non-union rates of 10% have been seen. The initial radiographic displacement parameters may be of significance in determining whether non-operative treatment might fail.</p><p><strong>Aims: </strong>To determine whether the initial radiographic displacement of humeral shaft fractures can predict non-union rates and assist in decision-making for surgical intervention.</p><p><strong>Methods: </strong>A retrospective cohort study was performed to identify all patients with humeral shaft fractures presenting to a regional trauma centre over a three-year period. Three-observer measurements were taken on defined radiographic parameters. These were compared between groups treated successfully with surgery and with non-operative intervention. A subset group was identified who failed non-operative treatment and required delayed surgery. Statistical analysis was performed to determine whether the group that failed non-operative treatment met the proposed radiographic parameters predicting treatment failure.</p><p><strong>Results: </strong>Eighty patients were identified over the defined three-year period. Failure of non-operative management occurred in 6/43 (13.95%) patients. Failed conservative treatment was associated with increased age, female gender, and increased AP translation of lateral radiographs. Fractures successfully treated non-operatively showed a significantly lower AP translation on the lateral radiographs compared to patients who failed non-operative treatment 9.69 mm (IQR 4.90-14.05 mm) versus 22.61 mm (IQR 15.73-23.83 mm), p-value = 0.042.</p><p><strong>Conclusion: </strong>Significant initial AP displacement may be associated with failure of non-operative management. This study highlights the importance of initial radiographic parameters of displacement in predicting possible failure of non-operative management for midshaft humerus fractures.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between psoriasis and subclinical atherosclerosis defined by carotid intima-media thickness (CIMT) in patients with psoriasis vulgaris: a systematic review and meta-analysis.","authors":"Maryam Yousefi, Pouyan Shakeri, Azin Tahvildari, Hossein Salehi Omran, Sara Sharifi, Mohammad A Shafiee","doi":"10.1007/s11845-025-03875-x","DOIUrl":"https://doi.org/10.1007/s11845-025-03875-x","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a chronic inflammatory condition that increases the risk of vascular issues, ranging from mild artery damage to severe events such as heart attacks and strokes. This systematic review and meta-analysis aimed to evaluate the relationship between psoriasis and carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis.</p><p><strong>Methods: </strong>A comprehensive search of Embase, PubMed/Medline, Scopus, and CINAHL via EBSCO was conducted up until June 2023 using the terms \"Atherosclerosis AND Psoriasis.\" Studies measuring CIMT to assess atherosclerosis in psoriasis patients were included. A meta-analysis and subgroup analysis were performed to calculate the overall mean difference in CIMT between psoriasis patients and control groups. Studies published between 2009 and 2023 were reviewed, including 28 case-control, 18 cross-sectional, and two prospective cohort studies.</p><p><strong>Results: </strong>The total sample size was 15,914 participants, with individual study sizes ranging from 32 to 8271. Of the included studies, 44 revealed a significant association between psoriasis and CIMT, suggesting a higher risk of subclinical atherosclerosis in psoriasis patients. The meta-analysis found that psoriasis patients had a CIMT 0.17 mm higher than the control group (95% CI 0.12- 0.22). However, six studies did not show a statistically significant mean difference.</p><p><strong>Conclusions: </strong>This study emphasizes the importance of assessing cardiovascular risk in psoriasis patients, particularly those with moderate-to-severe disease. It highlights the need for tailored interventions to manage the increased risk of atherosclerosis in this population.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHLPP and LAMP2 predict favorable treatment response and survival in multiple myeloma patients who receive induction treatment with bortezomib.","authors":"Qingkun Han, Wei Han, Cuiping Li, Qianqian Xie, Xuebing Jing","doi":"10.1007/s11845-025-03879-7","DOIUrl":"https://doi.org/10.1007/s11845-025-03879-7","url":null,"abstract":"<p><strong>Objective: </strong>Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) increases the sensitivity of multiple myeloma (MM) cells to bortezomib by upregulating lysosome-associated membrane protein 2 (LAMP2), while their clinical role in MM patients is unclear. This study aimed to assess the intercorrelation between PHLPP and LAMP2, as well as their associations with treatment response and survival in MM patients who received induction treatment with bortezomib.</p><p><strong>Methods: </strong>A total of 59 MM patients who received induction treatment with bortezomib were included. PHLPP and LAMP2 were detected by quantitative polymerase chain reaction in bone marrow plasma cells that were collected before treatment. Treatment response, progression-free survival (PFS), and overall survival (OS) were assessed.</p><p><strong>Results: </strong>PHLPP was positively correlated with LAMP2, whether they were considered as continuous variables (r = 0.469, P < 0.001) or categorized as high and low expressions (P = 0.003). PHLPP and LAMP2 were elevated in patients who achieved complete remission (CR) versus those who did not, as well as in patients who achieved partial remission (PR) and above versus those who had less than PR (all P < 0.05). By chi-square test, high PHLPP (cut by the median) was linked with the achievement of PR and above (P = 0.015), and high LAMP2 (cut by the median) was related to the achievement of CR (P = 0.030). High PHLPP (P = 0.016) and LAMP2 (P = 0.037) were associated with prolonged PFS, but not OS (both P > 0.05).</p><p><strong>Conclusion: </strong>PHLPP is positively correlated with LAMP2, and their high expressions predict favorable treatment response and PFS in MM patients who receive induction treatment with bortezomib.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-144-3p participates in the regulation of gestational diabetes mellitus by targeting FOXO1.","authors":"Meiyi Chen, Shaomeng Sun, Lei Ma, Li Bian, Biao Zhao, Haiyong Zeng","doi":"10.1007/s11845-025-03894-8","DOIUrl":"https://doi.org/10.1007/s11845-025-03894-8","url":null,"abstract":"<p><strong>Background: </strong>The pivotal role of microRNAs (miRNAs) in the pathogenesis of gestational diabetes mellitus (GDM) have been increasingly highlighted in recent studies.</p><p><strong>Aims: </strong>To investigate miR-144-3p expression in patients with GDM and its potential mechanisms in GDM.</p><p><strong>Methods: </strong>According to the inclusion criteria, 98 pregnant women with GDM and 98 normal pregnant women were statistically selected. The levels of miR-144-3p were determined by RT-qPCR. The ROC curve was used to evaluate the diagnostic value of miR-144-3p for GDM. Pearson analysis was used to analyze the correlation. HRT-8/SVneo cells were induced by high glucose in vitro to mimic the high glucose environment of GDM. On this basis, the cell models of miR-144-3p overexpression and knockdown were established to investigate the potential mechanism of miR-144-3p in GDM.</p><p><strong>Results: </strong>The level of miR-144-3p in GDM group was markedly higher than that in normal pregnant women. In terms of predicting GDM, miR-144-3p demonstrated high accuracy. MiR-144-3p was positively linked to blood glucose markers in GDM. Further investigation has confirmed that miR-144-3p harbors a binding site for FOXO1 and can directly modulate its expression. Moreover, miR-144-3p targeted FOXO1 to affect the proliferation of trophoblast cells.</p><p><strong>Conclusion: </strong>The expression of miR-144-3p is elevated in pregnant women with GDM. MiR-144-3p may be involved in the regulation of GDM by targeting FOXO1.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic screening in cohort of Egyptian patients with pulmonary arterial hypertension disease.","authors":"Samar I E Ayyad, Miral M Refeat, Engy A Ashaat, Abdel-Rahman B Abdel-Ghaffar, Germine M Hamdy","doi":"10.1007/s11845-025-03889-5","DOIUrl":"https://doi.org/10.1007/s11845-025-03889-5","url":null,"abstract":"<p><strong>Background: </strong>Variants in the bone morphogenetic protein 2 receptor gene (BMPR2) are the most frequent genetic cause of pulmonary arterial hypertension (PAH). However, correlation of BMPR2 variants and PAH clinical phenotype remains to be elucidated.</p><p><strong>Methods and results: </strong>The goal of the present study is to investigate variants of the causative gene (BMPR2) in 25 Egyptian patients clinically pre-diagnosed with PAH symptoms and 10 healthy candidates using Sanger sequencing technique. Three pathogenic heterozygous missense variants have been illustrated in BMPR2 gene, two novel variants (V387E, E481K) in exon 9 and 11 respectively and one previously reported missense variant (C496G) in exon 11. The remaining 22 patients as well as the 10 healthy individuals showed no pathogenic variants.</p><p><strong>Conclusion: </strong>Further studies on larger number of participants, using advanced NGS technique, should be performed to enrich information about genotype/phenotype correlations and incidence of PAH disease among Egyptian population; thus, it would provide families of PAH patients with accurate genetic counseling in order to prevent disease recurrence.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved performance of cementless total knee arthroplasty (TKA)across international registries: a comparative review.","authors":"Meadhbh Ni Mhiochain de Grae, Armon Nasehi, David F Dalury, Bas A Masri, Gerard A Sheridan","doi":"10.1007/s11845-025-03888-6","DOIUrl":"https://doi.org/10.1007/s11845-025-03888-6","url":null,"abstract":"<p><strong>Background: </strong>Cementless fixation in total knee arthroplasty (TKA) has been associated with higher revision rates in the past. However, due to advancements in design, as well as surgical techniques, cementless TKA performance has significantly improved. The advantages of cementless fixation include reduced cement-related complications, shorter operating times, and the potential benefits of osseointegration. We aim to assess the improvement in revision rates for cementless TKA over the last 9 years based on international registry reports.</p><p><strong>Methods: </strong>A comprehensive retrospective review was conducted of six major English-speaking knee arthroplasty registries across the world including the National Joint Registry of England and Wales, Northern Islan Isle of Man and Guernsey (herby referred to as British), Swedish, Canadian, American, Australian, and New Zealand National Joint Registry. Data was collected from the year 2014 along with the most recent annual report published: 2022 or 2023. Data points collected included usage rates of cemented and cementless prostheses for primary TKA, their respective revision rates, and indications for revision.</p><p><strong>Results: </strong>Across four databases, there was an average 8.3% increase in the utilization of cementless fixation for primary TKA over the past decade. Three registries reported a reduction in revision rates for cementless fixation. Lower revision rates for cementless compared to cemented TKA were observed in the most recent American (3.2% cemented vs. 2.8% cementless) and New Zealand annual reports (11.8% cemented vs. 4.5% cementless). In 2022, the British registry reported lower rates of revision for infection with cementless fixation (0.56 vs. 0.89).</p><p><strong>Conclusion: </strong>International registries demonstrate increased utilization of cementless TKA. Cementless TKA was reported to have lower revision rates in the most recent US and New Zealand annual reports when compared to cemented TKA.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The patients' perspective of bedside teaching in the post-Covid era.","authors":"Angela Kearns, James Lennon, Lucy Hurley","doi":"10.1007/s11845-025-03900-z","DOIUrl":"https://doi.org/10.1007/s11845-025-03900-z","url":null,"abstract":"<p><strong>Background: </strong>Bedside teaching with real patients is vital to the education of medical students. With the onset of the Covid-19 pandemic in 2020, all student-patient interactions were suspended in order to prevent the spread of the virus. Research has previously focussed on the medical professional and medical student views concerning bedside teaching, with less of a focus on patient insights.</p><p><strong>Aims: </strong>The purpose and aims of this study were to explore the patient's perspectives of encountering medical students and contributing to their learning in the clinical setting, beyond the Covid restrictions.</p><p><strong>Methods: </strong>Qualitative semi-structured interviews were carried out with a cohort of Mayo University hospital inpatients, who had participated in a bedside teaching session. An interview guide was employed to facilitate consistent and analogous data. An interpretative phenomenological approach was used for data analysis yielding a number of themes.</p><p><strong>Results: </strong>Participants recognised the value of their involvement in the clinical education of future doctors, in addition to the positive impacts of such contributions for their own future healthcare. Participants had no concerns about partaking in bedside teaching sessions relating to Covid infection.</p><p><strong>Conclusions: </strong>This study assessed the opinions of hospital inpatients with regards to participating in clinical teaching sessions and found that they do not perceive their role as passive.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}